CA2266347A1 - Electroporation and iontophoresis catheter with porous balloon - Google Patents

Electroporation and iontophoresis catheter with porous balloon

Info

Publication number
CA2266347A1
CA2266347A1 CA002266347A CA2266347A CA2266347A1 CA 2266347 A1 CA2266347 A1 CA 2266347A1 CA 002266347 A CA002266347 A CA 002266347A CA 2266347 A CA2266347 A CA 2266347A CA 2266347 A1 CA2266347 A1 CA 2266347A1
Authority
CA
Canada
Prior art keywords
electrode
molecules
cells
distal end
predetermined
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002266347A
Other languages
French (fr)
Other versions
CA2266347C (en
Inventor
Gunter A. Hofmann
Lois J. Crandell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetronics Inc
Original Assignee
Genetronics, Inc.
Gunter A. Hofmann
Lois J. Crandell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetronics, Inc., Gunter A. Hofmann, Lois J. Crandell filed Critical Genetronics, Inc.
Publication of CA2266347A1 publication Critical patent/CA2266347A1/en
Application granted granted Critical
Publication of CA2266347C publication Critical patent/CA2266347C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A61N1/303—Constructional details
    • A61N1/306—Arrangements where at least part of the apparatus is introduced into the body

Abstract

An electroporation apparatus for introducing molecules into cells at a selected location within a cavity in the body of a patient, comprises an elongated catheter (10) having a proximal end (16) and a distal end (14) and a guide wire extending from the proximal end to the distal end an inflatable balloon (14) carried by the distal end, the balloon having an inner inflatable bladder and an outer perforated bladder defining a chamber therebetween, a first electrode (26) on an outer surface of the outer perforated bladder, a second electrode (24) spaced from the first electrode, a remote electrode (25), a lumen for delivering a predetermined quantity of a fluid medium carrying preselected molecules into the chamber to be infused into the body cavity at the predetermined location; and a source of power (47) for applying a voltage pulse between selected pairs of the electrodes for transport of the molecules by iontophoresis and/or repeatedly generating electric fields of a predetermined amplitude and duration inducing the walls of a plurality of cells at the predetermined location to be transiently permeable to enable the molecules to enter the cells.
CA002266347A 1996-10-10 1997-03-11 Electroporation and iontophoresis catheter with porous balloon Expired - Fee Related CA2266347C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/729,007 1996-10-10
US08/729,007 US5704908A (en) 1996-10-10 1996-10-10 Electroporation and iontophoresis catheter with porous balloon
PCT/US1997/003760 WO1998015318A1 (en) 1996-10-10 1997-03-11 Electroporation and iontophoresis catheter with porous balloon

Publications (2)

Publication Number Publication Date
CA2266347A1 true CA2266347A1 (en) 1998-04-16
CA2266347C CA2266347C (en) 2005-12-20

Family

ID=24929196

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002266347A Expired - Fee Related CA2266347C (en) 1996-10-10 1997-03-11 Electroporation and iontophoresis catheter with porous balloon

Country Status (5)

Country Link
US (1) US5704908A (en)
EP (1) EP1011791A1 (en)
JP (1) JP3522287B2 (en)
CA (1) CA2266347C (en)
WO (1) WO1998015318A1 (en)

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Also Published As

Publication number Publication date
JP2000508220A (en) 2000-07-04
CA2266347C (en) 2005-12-20
JP3522287B2 (en) 2004-04-26
WO1998015318A1 (en) 1998-04-16
EP1011791A1 (en) 2000-06-28
US5704908A (en) 1998-01-06

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