CA2269750A1 - Incremental absorbance scanning of liquid in dispensing tips - Google Patents

Incremental absorbance scanning of liquid in dispensing tips Download PDF

Info

Publication number
CA2269750A1
CA2269750A1 CA002269750A CA2269750A CA2269750A1 CA 2269750 A1 CA2269750 A1 CA 2269750A1 CA 002269750 A CA002269750 A CA 002269750A CA 2269750 A CA2269750 A CA 2269750A CA 2269750 A1 CA2269750 A1 CA 2269750A1
Authority
CA
Canada
Prior art keywords
tip
detector
liquid
light
scanner
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002269750A
Other languages
French (fr)
Other versions
CA2269750C (en
Inventor
Ronald F. Brookes
Merrit N. Jacobs
Alan J. Lowne
James D. Shaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Clinical Diagnostics Inc
Original Assignee
Ortho Clinical Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Clinical Diagnostics Inc filed Critical Ortho Clinical Diagnostics Inc
Publication of CA2269750A1 publication Critical patent/CA2269750A1/en
Application granted granted Critical
Publication of CA2269750C publication Critical patent/CA2269750C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N2035/1025—Fluid level sensing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/119163—Automated chemical analysis with aspirator of claimed structure

Abstract

A method and apparatus for detecting improper liquid content of a metering tip of an analyzer. The method detects the content or status using radiation between 630 and 2000 nm, and comprises the steps of: a) aspirating the liquid into one of the tips to fill the tip to a nominal level; b) scanning the liquid in the tip by a scanner comprising a light source and a light detector, the source and detector being aligned along a direction that is generally normal to the tip axis; c) providing relative motion between the tip and the scanner while the step b) is conducted, so that the scanner scans from a first position below the tip where a pendant drop of the aqueous liquid would be located if present, to a predetermined second position above the first position that represents the nominal level; d) while conducting steps b) and c), separately detecting at each of several portions of the tip between and including the first and second positions, the amount of light transmitted to the detector, so that all liquid-containing levels within the tip are detected; e) comparing the detected light of step d) with light known to be transmitted if liquid is present only at all of the levels, free of air bubbles; and f) flagging the results as being in error if water is detected at the first position; or if it is not detected because of air bubbles at any one of the levels within the tip up to and including the second position; or if it is detected above the second position. The apparatus features: a) a scanner comprising a light source, a light detector, and a mechanism for transmitting light from the source to the detector at a wavelength which is between about 800 and about 2000 nm; b) moving mechanism for providing relative motion of one of the tips past the scanner so that the scanner scans the tip and its contents; c) a controller of the moving mechanism and the detector that directs the detector to detect light transmitted through the tip to the detector at at least several adjacent portions of the tip, as well as just below the tip where any pendant drop would be located; and d) a comparator that compares the light transmitted at the several levels with that known to represent the tip containing bubble-free liquid at each of the levels.
CA002269750A 1998-04-27 1999-04-22 Incremental absorbance scanning of liquid in dispensing tips Expired - Fee Related CA2269750C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8320898P 1998-04-27 1998-04-27
US60/083,208 1998-04-27

Publications (2)

Publication Number Publication Date
CA2269750A1 true CA2269750A1 (en) 1999-10-27
CA2269750C CA2269750C (en) 2007-03-20

Family

ID=22176874

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002269750A Expired - Fee Related CA2269750C (en) 1998-04-27 1999-04-22 Incremental absorbance scanning of liquid in dispensing tips

Country Status (7)

Country Link
US (1) US6235534B1 (en)
EP (1) EP0953843B1 (en)
JP (1) JPH11337559A (en)
AT (1) ATE256292T1 (en)
AU (1) AU760266B2 (en)
CA (1) CA2269750C (en)
DE (1) DE69913424T2 (en)

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US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986944B2 (en) * 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
US7166443B2 (en) * 2001-10-11 2007-01-23 Aviva Biosciences Corporation Methods, compositions, and automated systems for separating rare cells from fluid samples
US20050043407A1 (en) * 2003-08-22 2005-02-24 Pfizer Inc Pharmaceutical composition for the prevention and treatment of addiction in a mammal
US20050101025A1 (en) * 2003-11-12 2005-05-12 Ho Winston Z. Apparatus for proteins and nucleic acids analysis
US7307718B2 (en) 2004-02-23 2007-12-11 Ortho-Clinical Diagnostics, Inc. Determining an analyte by multiple measurements through a cuvette
JP4753645B2 (en) * 2005-07-11 2011-08-24 ベックマン コールター， インコーポレイテッド Automatic analyzer
JP4593404B2 (en) * 2005-08-29 2010-12-08 シスメックス株式会社 Liquid sample suction monitoring method and apparatus, and liquid sample analyzer
US7870797B2 (en) * 2006-04-03 2011-01-18 Artel, Inc. Apparatus and method for aspirating and dispensing liquid
WO2007124346A2 (en) * 2006-04-19 2007-11-01 Archivex Llc Micro-drop detection and detachment
JP2007303937A (en) * 2006-05-10 2007-11-22 Olympus Corp Autoanalyzer
CA2657621A1 (en) * 2006-07-14 2008-01-17 Aviva Biosciences Corporation Methods and compositions for detecting rare cells from a biological sample
US11174458B2 (en) 2007-04-23 2021-11-16 Koligo Therapeutics, Inc. Cell separation apparatus and methods of use
CN104502579B (en) 2007-10-02 2018-04-13 赛拉诺斯知识产权有限责任公司 Modular point-of-care devices and its application
EP2112514A1 (en) * 2008-04-24 2009-10-28 bioMérieux BV Method and apparatus for checking the fluid in a pipet tip
US8136690B2 (en) 2009-04-14 2012-03-20 Microsoft Corporation Sensing the amount of liquid in a vessel
EP2666008B1 (en) 2011-01-21 2021-08-11 Labrador Diagnostics LLC Systems and methods for sample use maximization
JP5850665B2 (en) * 2011-08-02 2016-02-03 栄研化学株式会社 Immunoassay device and immunoassay method
WO2013036941A2 (en) 2011-09-09 2013-03-14 Gen-Probe Incorporated Automated sample handling instrumentation, systems, processes, and methods
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
CN104737026A (en) * 2012-10-12 2015-06-24 皇家飞利浦有限公司 Optical fill detection
US10422806B1 (en) 2013-07-25 2019-09-24 Theranos Ip Company, Llc Methods for improving assays of biological samples
GB2525679A (en) * 2014-05-02 2015-11-04 Univ Singapore A disposable measurement tip and method for use thereof
AU2015335904B2 (en) 2014-10-21 2020-09-03 Gen-Probe Incorporated Method and apparatus for printing on an object having a curved surface
JP6609429B2 (en) * 2015-06-30 2019-11-20 日本光電工業株式会社 Blood analysis method and blood analyzer
CA3040522C (en) * 2016-10-28 2023-09-05 Timothy Hansen Positive dispense verification sensor
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Also Published As

Publication number Publication date
EP0953843A3 (en) 2000-09-06
EP0953843A2 (en) 1999-11-03
AU760266B2 (en) 2003-05-08
DE69913424D1 (en) 2004-01-22
ATE256292T1 (en) 2003-12-15
AU2397599A (en) 1999-11-04
JPH11337559A (en) 1999-12-10
DE69913424T2 (en) 2004-10-14
CA2269750C (en) 2007-03-20
US6235534B1 (en) 2001-05-22
EP0953843B1 (en) 2003-12-10

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MKLA Lapsed

Effective date: 20130422