CA2275766C - Heart wall tension reduction apparatus and method - Google Patents

Heart wall tension reduction apparatus and method Download PDF

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Publication number
CA2275766C
CA2275766C CA002275766A CA2275766A CA2275766C CA 2275766 C CA2275766 C CA 2275766C CA 002275766 A CA002275766 A CA 002275766A CA 2275766 A CA2275766 A CA 2275766A CA 2275766 C CA2275766 C CA 2275766C
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Prior art keywords
chamber
heart
wall
tension
anchor
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CA002275766A
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French (fr)
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CA2275766A1 (en
Inventor
Cyril J. Schweich, Jr.
Todd J. Mortier
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Edwards Lifesciences Corp
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Myocor Inc
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Priority claimed from US08/933,456 external-priority patent/US5961440A/en
Application filed by Myocor Inc filed Critical Myocor Inc
Publication of CA2275766A1 publication Critical patent/CA2275766A1/en
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2478Passive devices for improving the function of the heart muscle, i.e. devices for reshaping the external surface of the heart, e.g. bags, strips or bands
    • A61F2/2487Devices within the heart chamber, e.g. splints
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2478Passive devices for improving the function of the heart muscle, i.e. devices for reshaping the external surface of the heart, e.g. bags, strips or bands
    • A61F2/2481Devices outside the heart wall, e.g. bags, strips or bands
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/122Clamps or clips, e.g. for the umbilical cord
    • A61B17/1227Spring clips
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00238Type of minimally invasive operation
    • A61B2017/00243Type of minimally invasive operation cardiac
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • A61B2017/0404Buttons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • A61B2017/0417T-fasteners
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • A61B2017/0427Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors having anchoring barbs or pins extending outwardly from the anchor body
    • A61B2017/0429Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors having anchoring barbs or pins extending outwardly from the anchor body the barbs being expanded by a mechanical mechanism which also locks them in the expanded state
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • A61B2017/0427Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors having anchoring barbs or pins extending outwardly from the anchor body
    • A61B2017/0435Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors having anchoring barbs or pins extending outwardly from the anchor body the barbs being separate elements mechanically linked to the anchor, e.g. by pivots
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0401Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
    • A61B2017/0446Means for attaching and blocking the suture in the suture anchor
    • A61B2017/0461Means for attaching and blocking the suture in the suture anchor with features cooperating with special features on the suture, e.g. protrusions on the suture
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/0469Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
    • A61B2017/048Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery for reducing heart wall tension, e.g. sutures with a pad on each extremity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B2017/0496Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials for tensioning sutures
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/909Method or apparatus for assembling prosthetic
    • Y10S623/91Heart

Abstract

This invention is an apparatus for treatment of a failing heart by reducing the wall tension therein, In one embodiment, the apparatus includes a tension member (18) for drawing at least two walls of a heart charnber toward each other. Methods for placing the apparatus on the heart are also provided.

Description

HEART WALL TENSION REDUCTION APPARATUS AND METHOD
Field of the Invention The present invention pertains to the field of apparatus for treatment of a failing heart. In particular, the apparatus of the present invention is directed toward reducing the wall stress in the failing heart.
Background of the Invention The syndrome of heart failure is a common course for the progression of many forms of heart disease. Heart failure may be considered to be the condition in which an abnormality of cardiac function is responsible for the inability of the heart to pump blood at a rate commensurate with the requirements of the metabolizing tissues, or can do so only at an abnormally elevated filling pressure. There are many specific disease processes that can lead to heart failure with a resulting difference in pathophysiology of the failing heart, such as the dilatation of the left ventricular chamber. Etiologies that can lead to this form of failure include 21439187.2 idiopathic cardiomyopathy, viral cardiomyopathy, and ischemic cardiomyopathy.
The process of ventricular dilatation is generally the result of chronic volume overload or specific damage to the myocardium. In a normal heart that is exposed to long term increased cardiac output requirements, for example, that of an athlete, there is an adaptive process of slight ventricular dilation and muscle myocyte hypertrophy. In this way, the heart fully compensates for the increased cardiac output requirements. With damage to the myocardium or chronic volume overload, however, there are increased requirements put on the contracting myocardium to such a level that this compensated state is never achieved and the heart continues to dilate.
The basic problem with a large dilated left ventricle is that there is a significant increase in wall tension and/or stress both during diastolic filling and during systolic contraction. In a normal heart, the adaptation of muscle hypertrophy (thickening) and ventricular dilatation maintain a fairly constant wall tension for systolic contraction. However, in a failing heart, the ongoing dilatation is greater than the hypertrophy and the result is a rising wall tension requirement for systolic contraction. This is felt to be an ongoing insult to the muscle myocyte resulting in
-2-further muscle damage. The increase in wall stress is also true for diastolic filling. Additionally, because of the lack of cardiac output, there is generally a rise in ventricular filling pressure from several physiologic mechanisms. Moreover, in diastole there is both a diameter increase and a pressure increase over normal, both contributing to higher wall stress levels. The increase in diastolic wall stress is felt to be the primary contributor to ongoing dilatation of the chamber.
Prior art treatments for heart failure fall into three generally categories. The first being pharmacological, for example, diuretics. The second being assist systems, for example, pumps. Finally, surgical treatments have been experimented with, which are described in more detail below.
With respect to pharmacological treatments, diuretics have been used to reduce the workload of the heart by reducing blood volume and preload. Clinically, preload is defined in several ways including left ventricular end diastolic pressure (LVEDP?, or left ventricular end diastolic volume (LVEDV).
Physiologically, the preferred definition is the length of stretch of the sarcomere at end diastole. Diuretics reduce extra cellular fluid which builds in congestive heart failure patients increasing preload conditions.
Nitrates, arteriolar vasodilators, angiotensin converting
-3-WO 98/29041 PCTlUS97/24116 enzyme inhibitors have been used to treat heart failure through the reduction of cardiac workload through the reduction of afterload. Afterload may be defined as the tension or stress required in the wall of the ventricle during ejection. Inotropes like digoxin are cardiac glycosides and function to increase cardiac output by increasing the force and speed of cardiac muscle contraction. These drug therapies offer some beneficial effects but do not stop the progression of the disease.
Assist devices include mechanical pumps and electrical stimulators. Mechanical pumps reduce the load on the heart by performing all or part of the pumping function normally done by the heart. Currently, mechanical pumps are used to sustain the patient while a donor heart for transplantation becomes available for the patient. Electrical stimulation such as bi-ventricular pacing have been investigated for the treatment of patients with dilated cardiomyopathy.
There are at least three surgical procedures for treatment of heart failure: 1) heart transplant; 2) dynamic cardiomyoplasty; and 3) the Batista partial left ventriculectomy. Heart transplantation has serious limitations including restricted availability of organs and adverse effects of immunosuppressive therapies required following heart transplantation.
Cardiomyoplasty includes wrapping the heart with skeletal
-4-muscle and electrically stimulating the muscle to contract synchronously with the heart in order to help the pumping function of the heart. The Batista partial left ventriculectomy includes surgically remodeling the left ventricle by removing a segment of the muscular wall. This procedure reduces the diameter of the dilated heart, which in turn reduces the loading of the heart.
However, this extremely invasive' procedure reduces muscle mass of the heart.
Summary of the Invention The present invention pertains to a non-pharmacological, passive apparatus and method for the treatment of a failing heart. The device is configured to reduce the tension in the heart wall. It is believed to reverse, stop or slow the die;ease process of a failing heart as it reduces the energy consumption of the failing heart, decreases isovolumetric: contraction, increases sarcomere shortening during contraction and increases isotonic shortening which in turn increases stroke volume. The device reduces wall tension during diastole and systole.
In one embodiment, the apparatus includes a tension member for drawing at least two walls of the heart - 25 chamber toward each other to reduce the radius or area of the heart chamber in at least o:ne cross sectianal plane.
_5_ The tension member has anchoring members disposed at opposite ends for engagement with the heart or chamber wall.
In another embodiment, the apparatus includes a compression member for drawing at least two walls of a heart chamber toward each other. In one embodiment, the compression member includes a balloon. In another embodiment of the apparatus, a frame is provided for supporting the compression member.
Yet another embodiment of the invention includes a clamp having two ends biased toward one another for drawing at least two walls of a heart chamber toward each other. The clamp includes at least two ends having atraumatic anchoring member disposed thereon for engagement with the heart or chamber wall.
In yet another embodiment, a heart wall tension reduction apparatus is provided which includes a first tension member having two oppositely disposed ends and first and second elongate anchor members. A second tension member can be provided. One of the elongate anchors may be substituted for by two smaller anchors.
In an alternate embodiment of the heart wall tension reduction apparatus, an elongate compression member can be provided. First and second elongate lever members preferably extend from opposite ends of the compression member. A tension member extends between the first and second lever members.
The compression member of the above embodiment can be disposed exterior to, or internally of the heart. The tension member extends through the chamber or chambers to bias the lever members toward the heart.
In yet another embodiment of a heart wall tension reduction apparatus in accordance with the present invention, a rigid elongate frame member is provided.
The frame member can extend through one or more chambers of the heart. One or more cantilever members can be disposed at opposite ends of t=he frame member. Each cantilever member includes at 7_east one atraumatic pad disposed thereon. The atraumatic pads disposed at opposite ends of the frame member can be biased toward each other to compress the heart chamber.
One method of placing a heart wall tension apparatus or splint on a human heart includes the step of extending a hollow needle through at least one chamber of the heart such that each end of the needle is external to the chamber. A flexible leader is connected to a first end of a tension member. A second end of the tension member is connected to an atraumatic pad. The leader is advanced through the needle from one end of the needle to the other. The leader is furi~her advanced until the second end of the tension member is proximate the heart and the first end of the tension member is external to the heart. A second atraumatic pad is connected to the first end of the tension member such that the first and second atraumatic pads engage the heart.
An alternate method of placing the heart wall tension reduction apparatus on the heart includes the step of extending a guide member through at least one chamber of the heart such that each end of the guide member is external to the chamber. A tension member for use in this method has at least one lumen extending through at least a portion of the member. The guide member is placed in the lumen. The tension member is advanced over the guide member such that a first end of the tension member is disposed to one side of and external to the heart and a second end of the tension member is disposed to an opposite side of and external to the heart. A first atraumatic pad is connected to one end of the tension member and a second atraumatic pad is connected to the opposite end of the tension member.
Yet another method of placing a heart wall tension apparatus on a heart includes the step of extending a needle having a flexible tension member releasably connected thereto through at least one chamber of the heart such that opposite ends of the tension member are external to the chamber and exposed on opposite sides of the chamber. The needle is removed from the tension _g_ member. Then first and second atraumatic pads are connected to the tension member at opposite ends of the tension member.
Brief Description of the Drawinas Figure 1 is a transverse cross-section of the left and right ventricles of a human heart showing the placement of a splint in accordance with the present invention;
l0 Figure 2 is a transverse cross-section of the left and right ventricles of a human heart showing the placement of a balloon device in accordance with the present invention;
Figure 3 is a transverse cross-section of the left and right ventricles of a hi.zman heart showing the placement of an external compression frame structure in accordance with the present invention;
Figure 4 is a transverse cross-section of the left and right ventricles of a human heart showing a clamp in accordance with the present invention;
Figure 5 is a transverse cross-section of the left and right ventricles of a human heart showing a three tension member version of the splint of Figure 1;
Figure 6 is a transverse cross-section of the left and right ventricles of a human heart showing a four tension member version of the splint shown in Figure 1;

Figure 7 is a vertical cross-sectional view of the left ventricle of a human heart showing an alternate version of the splint in accordance with the present invention;
Figure 8 is an end of the splint shown in Figure 7;
Figure 9 is a vertical cross-sectional view of a chamber of a human heart showing another alternative embodiment of the splint in accordance with the present invention;
Figure 10 is a vertical cross-section of a chamber of a human heart showing another alternative configuration of splints in accordance with the present invention;
Figure 11 is a vertical cross-sectional view of a chamber of a human heart showing another embodiment of a splint in accordance with the present invention;
Figure 12 is a vertical cross-sectional view of a chamber of a human heart showing another embodiment of the splint in accordance with the present invention;
Figure 13 is a vertical cross-sectional view of a chamber of a human heart showing a compression member version of the splint -in accordance with the present invention;
Figure 14 is a vertical cross-sectional view of a chamber of a human heart showing another version of the splint shown in Figure 13;

Figure 15 is a vertical cross-sectional view of a chamber of a human heart showing a frame member version of the splint in accordance with the present invention;
Figure 16 is an end view of: the splint of Figure 15;
Figure 17 is a vertical cross-section of the left ventricle and atrium, the left ventricle having scar tissue;
Figure 18 is a vertical cross-section of the heart of Figure 7 showing the splint of Figure 1 drawing the scar tissue toward the opposite wall of the left ventricle;
Figure 19 is a vertical cross-section of the left ventricle and atrium of a human heart showing a version of the splint of Figure 1 having an elongate anchor bar;
Figure 20 is a side view of an undeployed hinged anchor member;
Figure 21 is a side view of a deployed hinged anchor member of Figure 10;
Figure 22 is a cross-sectional view of an captured ball anchor member;
Figure 23 is a perspective view of a cross bar anchor member;
Figure 24 is a vertical cross-sectional view of a chamber of a human heart showing a needle used for placement of splint in accordance with the present invention;

Figure 25 is a view of the heart and needle of Figure 24 showing a tension member being placed in the heart;
Figure 26 is a view of the heart shown in Figure 24 wherein oppositely disposed anchor pads are being joined by a tension member;
Figure 27 is a view of the heart of Figure 24, wherein two oppositely disposed anchor pads have been joined by two tension members;
Figure 28 is a view of a tension member having a lumen extending therethrough;
Figure 29 is a view of a tension member having lumens extending therethrough;
Figure 30 is a vertical cross-sectional view of a chamber of the heart and two pads, and a needle extending therethrough;
Figure 31 is a vertical cross-sectional view of a chamber of the heart showing a guidewire extending therethrough;
Figure 32 is a view of the heart of Figure 31, and two pads, and a guidewire extending therethrough;
Figure 33 is a vertical cross-sectional view of a chamber of the heart showing a needle connected to a tension member being inserted into the chamber;

Figure 34 is a vertical cross-sectional view of a chamber of a heart showing two anchors connected by a tension member;
Figure 35 is a vertical cross-sectional view of a chamber of the heart, showing a band surrounding the heart;
Figure 36 is a idealized cylindrical model of a left ventricle of a human heart;
Figure 37 is a splinted model of the left ventricle of Figure 14;
Figure 38 is a transverse cross-sectional view of Figure 15 showing various modeling parameters;
Figure 39 is a transver:~e cross-section of the splinted left ventricle of Figure 15 showing a hypothetical force distribution; and Figure 40 is a second transverse cross-sectional view of the model left ventricle of Figure 15 showing a hypothetical force distribution.
Detailed Description of the Invention Referring now to the drawings wherein like reference numerals refer to like elements throughout the several views, Figure 1 shows a transverse cross-section of a left ventricle 10 and a right ventricle 12 of a human heart 14. Extending through l:he left ventricle is a splint 16 including a tension member 18 and oppositely disposed anchors 20. Splint 16 as shown in Figure 1 has been positioned to draw opposite walls of left ventricle toward each other to reduce the "radius" of the left ventricular cross-section or the cross-sectional area
5 thereof to reduce left ventricular wall stresses. It should be understood that although the splint 16 and the alternative devices disclosed herein are described in relation to the left ventricle of a human heart, these devices could also be used to reduce the radius or cross-10 sectional area of the other chambers of a human heart in transverse or vertical directions, or at an angle between the transverse and vertical.
Figure 2 discloses an alternate embodiment of the present invention, wherein a balloon 200 is deployed adjacent the left ventricle. The size and degree of inflation of the balloon can be varied to reduce the radius or cross-sectional area of left ventricle 10 of heart 14 .
Figure 3 shows yet another alternative embodiment of the present invention deployed with respect to left ventricle 10 of human heart 14. Here a compression frame structure 300 is engaged with heart 14 at atraumatic anchor pads 310. A compression member 312 having an atraumatic surface 314 presses against a wall of left ventricle 10 to reduce the radius or cross-sectional area thereof .

Figure 4 is a transverse cross-sectional view of human heart 14 showing yet another embodiment of the present invention. In this case a clamp 400 having atraumatic anchor pads 410 biased toward each other is shown disposed on a wall of left ventricle 10. Here the radius or cross-sectional area of left ventricle 10 is reduced by clamping off the portion of the wall between pads 410. Pads 410 can be biased toward each other and/or can be held together by a locking device.
Each of the various embodiments of the present invention disclosed in Figures 1-4 can be made from materials which can remain implanted in the human body indefinitely. Such biocompati.ble materials are well known to those skilled in the art of clinical medical devices.
Figure 5 shows an alternate: embodiment of the splint of Figure 1 referred to in Figure 5 by the numeral 116.
The embodiment 116 shown in :E'igure 5 includes three tension members 118 as opposed to a single tension member 18 as shown in Figure 1. Figure 6 shows yet another embodiment of the splint 216 haring four tension members 218. It is anticipated that in some patients, the disease process of the failing heart may be so advanced that three, four or more tension members may be desirable to reduce the heart wall stresses more substantially than possible with a single tension member as shown in Figure 1.
Figure 7 is a partial vertical cross-section of human heart 14 showing left ventricle 10. In Figure 7, another splint embodiment 316 is shown having a tension member 318 extending through left ventricle 10. On opposite ends of tension member 318 are disposed elongate anchors or pads 320. Figure 8 is an end view of tension member 318 showing elongate anchor 320.
Figure 9 shows another embodiment of a splint 416 disposed in a partial vertical cross-section of human heart 14. Splint 416 includes two elongate anchors or pads 420 similar to those shown in Figures 7 and 8. In Figure 9, however, two tension members 418 extend through left ventricle 10 to interconnect anchors 420 on opposite sides of heart 14.
Figure 10 is a vertical cross section of heart 14 showing left ventricle 10. In this case, two splints 16 are disposed through left ventricle 10 and vertically spaced from each other to resemble the configuration of Figure 9.
Figure 11 is a vertical cross sectional view of the left ventricle of heart 14. Two alternate embodiment splints 516 are shown extending through left ventricle 10. Each splint 516 includes two tension members 518 interconnecting two anchors or pads 520.

Figure 12 is yet another vertical cross sectional view of left ventricle 10 of heart 14. An alternate embodiment 616 of the splint ie; shown extending through left ventricle 10. Splint 6:16 includes an elongate anchor pad 620 and two shorter anchors or pads 621.
Splint 616 includes two tension members 618. Each tension member 618 extends between anchors 620 and respective anchors 621.
Figure 13 is a vertical cross sectional view of left ventricle l0 of heart 14. A sp7_int 50 is shown disposed on heart 14. Splint 50 include: a compression member 52 shown extending through left ventricle 10. Opposite ends of compression member 52 are disposed exterior to left ventricle 10. Lever members 54 extend from each end of compression member 52 upwardly along the exterior surface of ventricle 10. A tension member 56 extends between lever members 54 to bias lever mfsmbers 54 toward heart 14 to compress chamber 10. Compression member 52 should be substantially rigid, but lever members 54 and to some degree compression member 52 should be flexible enough to allow tension member 56 to bias lever members 54 toward heart 14. Alternately, lever members 54 could be hinged to compression member 52 such th~~t lever members 54 could pivot about the hinge when biased toward heart 14 by tension member 56.

WO 98!29041 PCT/L1S97/24116 Figure 14 shows an alternate embodiment 156 of the splint shown in Figure 13. In this case lever members 154 are longer than members 54 as compression member 152 of splint 150 has been disposed to the exterior of left ventricle 10.
Figure 15 is a vertical cross sectional view of left ventricle 10 of heart 14. An alternate embodiment 250 of the splint is shown on heart 14. A preferably relatively rigid frame member 255 extends through ventricle 10.
l0 Disposed on opposite ends of frame 250 are cantilever member 254. Disposed on cantilever members 254 are atraumatic pads 258. Cantilever members 254 can be positioned along frame member 256 such that atraumatic pads 258 press against heart 14 to compress chamber 10.
Figure 16 is an end view of frame member 256 showing cantilever members 254 and pads 258.
It should be understood that each of the embodiments described above should be formed from suitable biocompatible materials known to those skilled in the art. The tension members can be formed from flexible or relatively more rigid material. The compression members and frame member should be formed from generally rigid material which may flex under load, but generally hold its shape.
Figure 17 is a partial vertical cross-section of human heart 14 showing left ventricle 10 and left atrium 22. As shown in Figure 7, heart: 14 includes a region of scar tissue 24 associated with an aneurysm or ischemia.
As shown in Figure 7, the scar tissue 24 increases the radius or cross-sectional area of left ventricle 10 in the region affected by the scar tissue. Such an increase in the radius or cross-sectional area of the left ventricle will result in greater wall stresses on the walls of the left ventricle.
Figure 18 is a vertical crc>ss-sectional view of the heart 14 as shown in Figure 7, wherein a splint 16 has been placed to draw the scar tis:~ue 24 toward an opposite wall of left ventricle 10. As a consequence of placing splint 16, the radius or cross-se=_ctional area of the left ventricle affected by the scar tissue 24 is reduced. The reduction of this radius or cross-sectional area results in reduction in the wall stress in the left ventricular wall and thus improves heart pumping efficiency.
Figure 19 is a vertical cro:~s-sectional view of left ventricle 10 and left atrium 22 of heart 14 in which a splint 16 has been placed. As shown in Figure 9, splint 16 includes an alternative anchor 26. The anchor 26 is preferably an elongate member having a length as shown in Figure 9 substantially greater than its width (not shown). Anchor bar 26 might be used to reduce the radius or cross-sectional area of than left ventricle in an instance where there is generalized enlargement of left ventricle 10 such as in idiopathic dilated cardiomyopathy. In such an instance, bar anchor 26 can distribute forces more widely than anchor 20.
Figures 20 and 21 are side views of a hinged anchor 28 which could be substituted for anchors 20 in undeployed and deployed positions respectively. Anchor 28 as shown in Figure 20 includes two legs similar to bar anchor 26. Hinged anchor 28 could include additional legs and the length of those legs could be varied to distribute the force over the surface of the heart wall.
In addition there could be webbing between each of the legs to give anchor 28 an umbrella-like appearance.
Preferably the webbing would be disposed on the surface of the legs which would be in contact with the heart wall.
Figure 22 is a cross-sectional view of a capture ball anchor 30. Capture ball anchor 30 can be used in place of anchor 20. Capture ball anchor 30 includes a disk portion 32 to distribute the force of the anchor on the heart wall, and a recess 34 for receiving a ball 36 affixed to an end of tension member 18. Disk 32 and recess 34 include a side groove which allows tension member 38 to be passed from an outside edge of disk 32 into recess 34. Ball 36 can then be advanced into recess 34 by drawing tension member 18 through an opening 38 in recess 34 opposite disk 32.

Figure 23 is a perspective view of a cross bar anchor 40. The cross bar anchor 40 can be used in place of anchors 20. The anchor 40 preferably includes a disk or pad portion 42 having a cross bar 44 extending over an opening 46 in pad 42. Tension member 18 can be extended through opening 46 and tied to cross bar 42 as shown.
In use, the various embodiments of the present invention are placed in or adj;~cent the human heart to reduce the radius or cross-section area of at least one chamber of the heart. This is done to reduce wall stress or tension in the heart or chamber wall to slow, stop or reverse failure of the heart. 7:n the case of the splint 16 shown in Figure 1, a canula can be used to pierce both walls of the heart and one end of the splint can be advanced through the canula from one side of the heart to the opposite side where an anchor can be affixed or deployed. Likewise, an anchor i.s affixed or deployed at the opposite end of splint 16.
Figure 24 is a vertical cross-sectional view of a chamber 10 of a heart 14. A needle 60 having a stylet inserted therethrough is inserted through chamber 10.
Figure 25 shows needle 60 disposed in heart 40 as shown in Figure 24. In Figure 25, stylet 62 has been removed.
A tension member 64 having a flexible leader 66 attached to one end of tension member 64, is threaded through needle 60 and an anchor 68.

WO 98129041 PCT/iJS97/24116 As shown in Figure 25, tension member 64 includes a generally elongate cylindrical shaft 70 having two generally cylindrical ends 72. Ends 72 preferably have a greater diameter than shaft 70. Also shown in Figure 25 is a perspective view of anchor 68 showing an opening 73 extending through anchor 68. Opening 73 includes a first cylindrically shaped opening 74 extending entirely through anchor 68. The diameter of opening 74 is preferably slightly greater than the diameter of end 72 of tension member 64. A groove 76 having a width preferably slightly greater than that of shaft 70 of tension member 64 extends from opening 74 to a generally cylindrical opening 78. Generally cylindrical opening 78 has a diameter approximately equal to end 72. Unlike opening 74, however, opening 78 includes a reduced base opening 80 which has a width approximately equal to that of groove 76. The width of the opening 80 is also less than the diameter of end 72 of tension member 64.
It can be appreciated that tension member 64 can be advanced through opening 74 until shaft 70 is disposed therein. Shaft 70 can be then slid transversely through groove 76. Tension member 64 can then be advanced further through opening 73 until end portion 72 enters opening 78 and seats against base 80.
Figure 26 shows the view of heart 14 shown in Figure 25. Needle 60 has been removed from heart 14. Tension member 64 has been advanced into chamber 10 and anchor 68 connected thereto is engaging the heart wall. Leader 66 has been advanced through yet another anchor 68 disposed on the opposite side of heart 7_4.
Figure 27 is a view of heart 14 of Figure 26. Two tension member 64 have been advanced through chamber 10.
Each tension member has been seated in respective opening 78 against respective bases 80 to form a splint in a configuration such as that shown in Figure 9.
It can be appreciated that each of the other tension member splints configurations can be placed on the heart in a similar manner. It can <~lso be appreciated that anchors 68 could initially be held against the heart and needle 60 advanced through anchors 68 and chamber 10 prior to extending leader 66 through the needle.
Figure 28 is a perspective view of a tension member 164 in accordance with the present invention. Tension member 164 is similar to tension member 64 described above in that it has an elongate, generally cylindrical shaft 170 and generally cylindrical ends 172. A lumen, however, extends longitudinally through tension member 164 along axis A.
Figure 29 is a perspective view of yet another embodiment of the tension member 264. Tension member 264, is similar to tension member 164, and includes an elongate cylindrical shaft 270 and cylindrical ends 272.

Lumens 282, however, extend through ends 272 aligned along axis B.
Figure 30 is a vertical, cross-sectional view of left ventricle 10 of heart 14. Anchors 68 have been placed on opposite sides of heart 14. A needle 160 extends through the lumen of tension member 164, left ventricle 10 and openings 73 in anchors 68. It can be appreciated that tension member 64 can be advanced through anchors 68 and left ventricle 10 and be seated within openings 78 as described above with respect to tension member 64.
Figure 31 is a vertical, cross-sectional view of left ventricle 10 of heart 14. A needle 60 has been advanced through the wall of left ventricle 10 and a guidewire 162 has been advanced through needle 60.
Figure 32 is the same view of heart 14 as shown in Figure 32. Needle 60, however, has been removed from heart 14 while guidewire 162 remains in position.
Anchors 68 have been placed on guidewire 162, on opposite sides of left ventricle 10. Tension member 264 has been threaded onto guidewire 162 through lumens 282. It can be appreciated that as discussed above with respect to tension member 164 above, tension member 264 can be advanced through left ventricle 10 such that ends 272 of tension member 264 seat in respective openings 78 against base 80.

Figure 33 is a vertical, cross-sectional view of left ventricle 10 of heart 14. In Figure 34, flexible tension member 364 has been connected to a needle 360.
Needle 360 is shown being advanced into left ventricle 10 through a ventricle wall.
Figure 34 is the same view of heart 14 as shown in Figure 33 except that tension member 364 has been advanced entirely through left ventricle 10 and anchors 68. Knots 384 have been tied at the ends of tension member 364 to prevent the ends of tension member 364 from passing through opening 73 of anchors 68.
It can be appreciated that the methods described above to advance the tension members through the ventricles can be repeated to advance the desired number of tension members through the ventricle for a particular configuration. The length of the tension members can be determined based upon the size and condition of the patient's heart. It should also be noted that although the left ventricle has been referred to here for illustrative purposes, that the apparatus and methods of this invention can also be used to splint multiple chambers of a patient's heart. as well as the right ventricle or either atrium.
Figure 35 is a vertical cross-section of left ventricle 10 of heart 14. Disposed about heart 14 is a band 716. Band 716 is shown as being sized relative to the heart such that the heart' s radius or cross-sectional area in a plane parallel to the length of the band is reduced relative to the radius at that location prior to placement of the band on the heart. The length of the heart perpendicular to the band is also increased. The band may be formed from a continuous ribbon of elastomeric material or from other biocompatible materials which are sufficiently strong to provide the desired effect of heart radius reduction and lengthening.
Figure 36 is a view of a cylinder or idealized heart chamber 48 which is used to illustrate the reduction of wall stress in a heart chamber as a result of deployment of the splint in accordance with the present invention.
The model used herein and the calculations related to this model are intended merely to illustrate the mechanism by which wall stress is reduced in the heart chamber. No effort is made herein to quantify the actual reduction which would be realized in any particular in vivo application.
Figure 37 is a view of the idealized heart chamber 48 of Figure 36 wherein the chamber has been splinted along its length L such that a "figure eight" cross-section has been formed along the length thereof. It should be noted that the perimeter of the circular transverse cross-section of the chamber in Figure 36 is equal to 'the perimeter of the figure eight transverse cross-section of Figure 37. Fo:r purposes of this model, opposite lobes of the figure in cross-section are assumed to be mirror images.
Figure 38 shows various parameters of the Figure 1 cross-section of the splinted idealized heart chamber of Figure 37. Where Q is the length of the splint between opposite walls of the chamber, Rz is the radius of each lobe, B is the angle between the two radii of one lobe which extends to opposite ends; of the portion of the splint within chamber 48 and h is the height of the triangle formed by the two radii and the portion of the splint within the chamber 48 (R1 is the radius of the cylinder of Figure 36). These various parameters are related as follows:
h = Rz COS ( B / 2 ) Q - 2 RZ SIN (B/2) Ra = RW / ( 27r - B ) From these relationships, the area of the figure eight cross-section can be calculated by:
AZ = 2~r (RZ) 2 (1-B/2~r) + h$
Where chamber 48 is unsplini=ed as shown in Figure 36 Al, the original cross-sectional area of the cylinder is equal to AZ where B - 180°, h :- 0 and $ - 2R2. Volume equals Az times length L and circumferential wall tension equals pressure within the chamber times Rz times the length L of the chamber.

Thus, for example, with an original cylindrical radius of four centimeters and a pressure within the chamber of 140 mm of mercury, the wall tension T in the walls of the cylinder is 104.4 newtons. When a 3.84 cm splint is placed as shown in Figures 37 and 38 such that $ = 3.84 cm, the wall tension T is 77.33 newtons.
Figures 39 and 40 show a hypothetical distribution of wall tension T and pressure P for the figure eight cross-section. As 8 goes from 180° to 0°, tension TS in the splint goes from 0 to a 2T load where the chamber walls carry a T load.
In yet another example, assuming that the chamber length L is a constant 10 cm, the original radius R1 is 4 cm, at a 140 mmHg the tension in the walls is 74.7 N.
If a 4.5 cm splint is placed such that P - 4.5 cm, the wall tension will then be 52.8 N.
It will be understood that this disclosure, in many respects, is only illustrative. Changes may be made in details, particularly in matters of shape, size, material, and arrangement of parts without exceeding the scope of the invention. Accordingly, the scope of the invention is as defined in the language of the appended claims.

Claims (141)

What is claimed is:
1. An apparatus for treatment of a heart, the apparatus comprising:
a passive member adapted to be adjacent a wall of a heart chamber for drawing portions of the chamber wall towards each other so that the portions remain in a non-contacting relationship; and an anchor device coupled to the member for fixing the member in a position adjacent the chamber wall.
2. The apparatus of claim 1, wherein the member is adapted to be placed within the chamber.
3. The apparatus of claim 2, wherein the member includes a tension member.
4. The apparatus of claim 3, wherein the member includes a plurality of tension members.
5. The apparatus of claim 3, wherein the anchor device includes a first anchor attached to a first end of the tension member and a second anchor attached to a second end of the tension member.
6. The apparatus of claim 5, wherein the first and second anchors are adapted to remain external the chamber and engage walls of the chamber.
7. The apparatus of claim 1, wherein the member is adapted to remain external the chamber.
8. The apparatus of claim 7, wherein the member includes a compression member.
9. An apparatus for treatment of a heart, the apparatus comprising:
a passive member adapted to be adjacent a wall of an intact heart chamber for drawing portions of the chamber wall towards each other, the member being configured so that all interior parts of the chamber remain in direct fluid communication; and an anchor device coupled to the member for fixing the member in a position adjacent the chamber wall.
10. The apparatus of claim 9, wherein the member is adapted to be placed within the chamber.
11. The apparatus of claim 10, wherein the member includes a tension member.
12. The apparatus of claim 11, wherein the member includes a plurality of tension members.
13. The apparatus of claim 11, wherein the anchor device includes a first anchor attached to a first end of the tension member and a second anchor attached to a second end of the tension member.
14. The apparatus of claim 13, wherein the first and second anchors are adapted to remain external the chamber and engage walls of the chamber.
15. The apparatus of claim 9, wherein the member is adapted to remain external the chamber.
16. The apparatus of claim 15, wherein the member includes a compression member.
17. An apparatus for treatment of a heart, the apparatus comprising:
a passive member adapted to be adjacent a wall of an intact heart chamber for altering a shape of the chamber, the member being configured so that all interior parts of the chamber remain in direct fluid communication; and an anchor device coupled to the member for fixing the member in a position adjacent the chamber wall.
18. The apparatus of claim 17, wherein the member is adapted to be placed within the chamber.
19. The apparatus of claim 18, wherein the member includes a tension member.
20. The apparatus of claim 19, wherein the member includes a plurality of tension members.
21. The apparatus of claim 19, wherein the anchor device includes a first anchor attached to a first end of the tension member and a second anchor attached to a second end of the tension member.
22. The apparatus of claim 21, wherein the first and second anchors are adapted to remain external the chamber and engage walls of the chamber.
23. The apparatus of claim 17, wherein the member is adapted to remain external the chamber.
24. The apparatus of claim 23, wherein the member includes a compression member.
25. The apparatus of claim 23, wherein the member includes a clamp.
26. An apparatus for treatment of a heart, the apparatus comprising:
a passive member adapted to be adjacent a wall of an intact heart chamber for reducing a radius of the chamber, the member being configured so that all interior parts of the chamber remain in direct fluid communication; and an anchor device coupled to the member for fixing the member in a position adjacent the chamber wall.
27. The apparatus of claim 26, wherein the member is adapted to be placed within the chamber.
28. The apparatus of claim 27, wherein the member includes a tension member.
29. The apparatus of claim 28, wherein the member includes a plurality of tension members.
30. The apparatus of claim 28, wherein the anchor includes a first anchor attached to a first end of the tension member and a second anchor attached to a second end of the tension member.
31. The apparatus of claim 30, wherein the first and second anchors are adapted to remain external the chamber and engage walls of the chamber.
32. The apparatus of claim 26, wherein the member is adapted to remain external the chamber.
33. The apparatus of claim 32, wherein the member includes a compression member.
34. The apparatus of claim 32, wherein the member includes a clamp.
35. An apparatus for treatment of a heart, the apparatus comprising:
a passive member adapted to be adjacent a wall of an intact heart chamber for reducing a cross-sectional area of the chamber, the member being configured so that all interior parts of the chamber remain in direct fluid communication; and an anchor device coupled to the member for fixing the member in a position adjacent the chamber wall.
36. The apparatus of claim 35, wherein the member is adapted to be placed within the chamber.
37. The apparatus of claim 36, wherein the member includes a tension member.
38. The apparatus of claim 37, wherein the member includes a plurality of tension members.
39. The apparatus of claim 37, wherein the anchor device includes a first anchor attached to a first end of the tension member and a second anchor attached to a second end of the tension member.
40. The apparatus of claim 39, wherein the first and second anchors are adapted to remain external the chamber and engage walls of the chamber.
41. The apparatus of claim 35, wherein the member is adapted to remain external the chamber.
42. The apparatus of claim 41, wherein the member includes a compression member.
43. The apparatus of claim 41, wherein the member includes a clamp.
44. An apparatus for treatment of a heart, the apparatus comprising:
a passive member adapted to be adjacent portions of a wall of a heart chamber for altering a shape of the chamber, the member being configured so that the portions remain in a non-contacting relationship; and an anchor device coupled to the member for fixing the member in a position adjacent the chamber wall.
45. The apparatus of claim 44, wherein the member is adapted to be placed within the chamber.
46. The apparatus of claim 45, wherein the member includes a tension member.
47. The apparatus of claim 46, wherein the member includes a plurality of tension members.
48. The apparatus of claim 46, wherein the anchor device includes a first anchor attached to a first end of the tension member and a second anchor attached to a second end of the tension member.
49. The apparatus of claim 48, wherein the first and second anchors are adapted to remain external the chamber and engage walls of the chamber.
50. The apparatus of claim 44, wherein the member is adapted to remain external the chamber.
51. The apparatus of claim 48, wherein the member includes a compression member.
52. An apparatus for treatment of a heart, the apparatus comprising:
a passive member adapted to be adjacent portions of a wall of a heart chamber for reducing a radius of the chamber, the member being configured so that the portions remain in a non-contacting relationship; and an anchor device coupled to the member for fixing the member in a position adjacent the chamber wall.
53. The apparatus of claim 52, wherein the member is adapted to be placed within the chamber.
54. The apparatus of claim 53, wherein the member includes a tension member.
55. The apparatus of claim 54, wherein the member includes a plurality of tension members.
56. The apparatus of claim 54, wherein the anchor device includes a first anchor attached to a first end of the tension member and a second anchor attached to a second end of the tension member.
57. The apparatus of claim 56, wherein the first and second anchors are adapted to remain external the chamber and engage walls of the chamber.
58. The apparatus of claim 52, wherein the member is adapted to remain external the chamber.
59. The apparatus of claim 58, wherein the member includes a compression member.
60. An apparatus for treatment of a heart, the apparatus comprising:
a passive member adapted to be adjacent portions of a wall of a heart chamber for reducing a cross-sectional area of the chamber, the member being configured so that the portions remain in a non-contacting relationship; and an anchor device coupled to the member for fixing the member in a position adjacent the chamber wall.
61. The apparatus of claim 60, wherein the member is adapted to be placed within the chamber.
62. The apparatus of claim 61, wherein the member includes a tension member.
63. The apparatus of claim 62, wherein the member includes a plurality of tension members.
64. The apparatus of claim 62, wherein the anchor device includes a first anchor attached to a first end of the tension member and a second anchor attached to a second end of the tension member.
65. The apparatus of claim 64, wherein the first and second anchors are adapted to remain external the chamber and engage walls of the chamber.
66. The apparatus of claim 60, wherein the member is adapted to remain external the chamber.
67. The apparatus of claim 66, wherein the member includes a compression member.
68. An apparatus for treatment of a heart, the apparatus comprising:
an elongate member having opposite ends the member adapted to be adjacent portions of a heart wall so that the portions remain in a non-contacting relationship; and an anchor disposed at each to engage the wall of the heart, the anchor including structure to receive and secure the member to the anchor.
69. The apparatus of claim 68, wherein the structure includes a recess portion of the anchor.
70. The apparatus of claim 69, wherein the recess portion receives an end of the member.
71. The apparatus of claim 70, wherein the end of the member includes a ball.
72. The apparatus of claim 68, wherein the structure includes a cross bar.
73. The apparatus of claim 72, wherein the member ties to the cross bar.
74. A device for treatment of a heart, the device comprising:
a static member configured to be positioned adjacent a wall of a heart chamber; and an anchoring mechanism coupled to the member to engage the wall of the heart chamber, wherein the device is configured to draw portions of the chamber wall toward each other during at least a portion of a cardiac cycle such that all interior parts of the chamber remain in direct fluid communication with each other.
75. The device of claim 74, wherein the member includes first and second opposite ends, and the anchoring mechanism includes an anchoring mechanism provided on each of the first and second opposite ends.
76. The device of claim 74, wherein the member is a tension member configured to be positioned transverse the heart chamber.
77. The device of claim 76, wherein an amount that portions of the chamber wall are drawn toward each other is determined by a length of the tension member transverse the heart chamber.
78. The device of claim 76, wherein the tension member includes more than one tension member configured to be positioned transverse the heart chamber.
79. The device of claim 74, wherein the anchoring mechanism is configured to engage an external surface of the heart wall.
80. The device of claim 74, wherein the member is adapted to remain external the chamber.
81. A device fox treatment of a heart, the device comprising:
a static member configured to be positioned adjacent a wall of a heart chamber; and an anchoring mechanism coupled to the member to engage the wall of the heart chamber wherein the device is configured to alter a shape of the chamber during at least a portion of a cardiac cycle such that all interior parts of the chamber remain in direct fluid communication with each other.
82. The device of claim 81, wherein the member includes first and second opposite ends, and the anchoring mechanism includes an anchoring mechanism provided on each of the first and second opposite ends.
83. The device of claim 81, wherein the member is a tension member configured to be positioned .transverse the heart chamber.
84. The device of claim 83, wherein an amount that the shape of the chamber is altered is determined by a length of the tension member transverse the heart chamber.
85. The device of claim 83, wherein the tension member includes more than one tension member configured to be positioned transverse the heart chamber.
86. The device of claim 81, wherein the anchoring mechanism is configured to engage an external surface of the heart wall.
87. The device of claim 81, wherein the member is adapted to remain external the chamber.
88. A device for treatment of a heart, the device comprising:

a static member configured to be positioned adjacent a wall of a heart chamber; and an anchoring mechanism coupled to the member to engage the wail of the heart chamber, wherein the device is configured to reduce a radius of the chamber during at least a portion of a cardiac cycle such that all interior parts of the chamber remain in direct fluid communication with each other.
89. The device of claim 88, wherein the member includes first and second opposite ends, and the anchoring mechanism includes an anchoring mechanism provided on each of the first and second opposite ends.
90. The device of claim 88, wherein the member is a tension member configured to be positioned transverse the heart chamber.
91. The device of claim 90, wherein an amount that the radius of the chamber is reduced is determined by a length of the tension member transverse the heart chamber.
92. The device of claim 90, wherein the tension member includes more than one tension member configured to be positioned transverse the heart chamber.
93. The device of claim 88, wherein the anchoring mechanism is configured to engage an external surface of the heart wall.
94. The device of claim 88, wherein the member is adapted to remain external the chamber.
95. A device for treatment of a heart, the device comprising:

a static member configured to be positioned adjacent a wall of a heart chamber; and an anchoring mechanism coupled to the member to engage the wall of the heart chamber, wherein the device is configured to draw portions of the chamber wall toward each other dining at least a portion of a cardiac cycle such that the portions of the chamber wall remain in a non-contacting relationship.
96. The device of claim 95, wherein the member includes first and second opposite ends, and the anchoring mechanism includes an anchoring mechanism provided on each of the first and second opposite ends.
97. The device of claim 95, wherein the member is a tension member configured to be positioned transverse the heart chamber.
98. The device of claim 97, wherein an amount that portions of the chamber wall are drawn toward each other is determined by a length of the tension member transverse the heart chamber.
99. The device of claim 97, wherein the tension member includes more than one tension member configured to be positioned transverse the heart chamber.
100. The device of claim 95, wherein the anchoring mechanism is configured to engage an external surface of the heart wall.
101. The device of claim 95, wherein the member is adapted to remain external the chamber.
102. A device for treatment of a heart, the device comprising:

a static member configured to be positioned adjacent portions of a wall of a heart chamber; and an anchoring mechanism coupled to the member to engage the wall of the heart chamber, wherein the device is configured to alter a shape of the chamber during at least portion of a cardiac cycle such that the portions of the wall remain in a non-contacting relationship.
103. The device of claim 102, wherein the member includes first and second opposite ends, and the anchoring mechanism includes an anchoring mechanism provided on each of the first and second opposite ends.
104. The device of claim 102, wherein the member is a tension member configured to be positioned transverse the heart chamber.
105. The device of claim 104, wherein an amount that the shape of the chamber is altered is determined by a length of the tension member transverse the heart chamber.
106. The device of claim 104, wherein the tension member includes more than one tension member configured to be positioned transverse the heart chamber.
107. The device of claim 102, wherein the anchoring mechanism is configured to engage an external surface of the heart wall.
108. The device of claim 102, wherein the member is adapted to remain external the chamber.
109. A device for treatment of a heart, the device comprising:

a static member configured to be positioned adjacent portions of a wall of a heart chamber; and an anchoring mechanism coupled to the member to engage the wall of the heart chamber, wherein the device is configured to reduce a radius of the chamber during at least a portion of a cardiac cycle such that the portions of the wall remain in a non-contacting relationship.
110. The device of claim 109, wherein the member includes first and second opposite ends, and the anchoring mechanism includes an anchoring mechanism provided on each of the first and second opposite ends.
111. The device of claim 109, wherein the member is a tension member configured to be positioned transverse the heart chamber.
112. The device of claim 111, wherein an amount that the radius of the chamber is reduced is determined by a length of the tension member transverse the heart chamber.
113. The device of claim 112, wherein the tension member includes more than one tension member configured to be positioned transverse the heart chamber.
114. The device of claim 109, wherein the anchoring mechanism is configured to engage an external surface of the heart wall.
115. The device of claim 109, wherein the member is adapted to remain external the chamber.
116. A device for treating a heart, the device comprising:

an elongate member having first and second oppositely disposed ends;

a first anchoring member attached to the first end of the elongate member; and a second anchoring member attached to the second end of the elongate member, wherein. each of the first and second anchoring members are configured to engage an exterior surface of a wall of the heart to maintain a position of the elongate member transverse the heart chamber.
117. The device of claim 116, wherein each of the first and second anchoring members has a disc-like shape .
118. The device of claim 116, wherein the heart chamber is the left ventricle.
119. The device of claim 116, wherein the first anchoring member is spaced from the second anchoring member.
120. The device of claim 116, wherein the device is configured to draw portions of the heart wall toward each other in a non-contacting relationship when the first and second anchoring members are engaged with the exterior portion of the wall and the elongate member is positioned transverse the heart chamber.
121. The device of claim 116, wherein the first anchoring member is configured to be attached to the elongate member after the elongate member is positioned transverse the heart chamber.
122. The device of claim 116, further comprising a mechanism configured to attach the elongate member to the first and second anchoring members.
123. The device of claim 116, wherein each of the first and second anchoring members define an opening configured to receive the elongate member.
124. A device for treating a heart, the device comprising:
a static member configured to be placed adjacent a wall of an intact heart chamber, the member having a surface adapted to press against the chamber wall to draw portions of the chamber wall towards each other and create a pair of lobes within the chamber that are in direct fluid communication.
125. The device of claim 124, wherein the surface is adapted to press against the chamber wall so that a radius of each of the pair off lobes is less than a radius of the chamber prior to creating the pair of lobes.
126. The device of claim 124, wherein the surface is adapted to press against the chamber wall so that the portions of the chamber wall drawn together remain in a noncontacting relationship.
127. The device of claim 124, wherein the member is adapted to remain external the chamber.
128. The device of claim 124, wherein the member includes at least one anchor device adapted to engage the chamber wall to fix the member in a position adjacent the chamber wall.
129. A system for treatment of a heart, comprising:

two elongate members each having two oppositely disposed ends;
and four anchoring members, wherein an anchoring member is provided on each of the ends of the elongate members, the anchoring members being configured to engage an exterior wall of a heart chamber to maintain a position of the corresponding elongate member with respect to the heart chamber, wherein each elongate member and corresponding anchoring members are configured to draw portions of the heart wall toward each other in a non-contacting relationship when the anchoring members are engaged with the exterior wall of the heart chamber and the corresponding elongate member is positioned with respect to the heart chamber.
130. The system of claim 129, wherein the two elongate members are positioned orthogonally relative to each other.
131. A device for treating a heart, the device comprising:
an elongate member having first and second oppositely disposed ends;

a first anchoring member attached to the first end of the elongate member; and a second anchoring member attached to the second end of the elongate member, wherein the first anchoring member is configured to engage a first exterior surface of a wall of the heart and the second anchoring member is configured to engage a second exterior surface of the wall of the heart to maintain a position of the elongate member transverse a heart chamber, and wherein during at least a portion of a cardiac cycle, the device is configured to distribute a first force on the first exterior surface that is substantially uniform about the first end of the elongate member, distribute a second force on the second exterior surface that is substantially uniform about the second end of the elongate member, and draw first and second portions of the heart wall toward each other in a non-contacting relationship.
132. The device of claim 131, wherein each of the first and second anchoring members is configured to extend substantially a same distance in both the vertical and transverse directions with respect to the first and second exterior surfaces respectively.
133. A device for treatment of a heart, the device comprising:
a static member configured to surround at least a portion of the heart, the member having a surface adapted to press against a wall of a chamber of the heart to alter a shape of the chamber without a bifurcation of the chamber.
134. The device of claim 133, wherein the member includes first and second opposite ends, and the surface includes a first surface and a second surface provided on the first and second opposite ends respectively.
135. The device of claim 134, wherein the member is adapted to remain external the chamber.
136. The device of claim 134, wherein the member includes first and second anchor pads having the first and second surfaces respectively.
137. A device for treatment of a heart, the device comprising:
a static member configured to be positioned transverse a chamber of the heart, the member having a surface adapted to press against a wall of the chamber to alter a shape of the chamber without a bifurcation of the chamber.
138. The device of claim 137, wherein the member includes first and second opposite ends, and the surface includes a first surface and a second surface provided on the first and second opposite ends respectively.
139. The device of claim 138, wherein the member includes first and second anchor pads having the first and second surfaces respectively.
140. The device of claim 139, wherein the anchor pads are configured to engage an external surface of the heart wall.
141. The device of claim 137, wherein the member includes more than one tension member configured to be positioned transverse the heart chamber.
CA002275766A 1997-01-02 1997-12-31 Heart wall tension reduction apparatus and method Expired - Lifetime CA2275766C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/778,277 US6050936A (en) 1997-01-02 1997-01-02 Heart wall tension reduction apparatus
US08/778,277 1997-01-02
US08/933,456 US5961440A (en) 1997-01-02 1997-09-18 Heart wall tension reduction apparatus and method
US08/933,456 1997-09-18
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Families Citing this family (523)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6592619B2 (en) 1996-01-02 2003-07-15 University Of Cincinnati Heart wall actuation device for the natural heart
US6520904B1 (en) 1996-01-02 2003-02-18 The University Of Cincinnati Device and method for restructuring heart chamber geometry
US5957977A (en) 1996-01-02 1999-09-28 University Of Cincinnati Activation device for the natural heart including internal and external support structures
US6123662A (en) * 1998-07-13 2000-09-26 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
US5702343A (en) * 1996-10-02 1997-12-30 Acorn Medical, Inc. Cardiac reinforcement device
US6406420B1 (en) * 1997-01-02 2002-06-18 Myocor, Inc. Methods and devices for improving cardiac function in hearts
US7883539B2 (en) 1997-01-02 2011-02-08 Edwards Lifesciences Llc Heart wall tension reduction apparatus and method
US6045497A (en) 1997-01-02 2000-04-04 Myocor, Inc. Heart wall tension reduction apparatus and method
US20030045771A1 (en) * 1997-01-02 2003-03-06 Schweich Cyril J. Heart wall tension reduction devices and methods
US6183411B1 (en) 1998-09-21 2001-02-06 Myocor, Inc. External stress reduction device and method
US6077214A (en) * 1998-07-29 2000-06-20 Myocor, Inc. Stress reduction apparatus and method
US6050936A (en) 1997-01-02 2000-04-18 Myocor, Inc. Heart wall tension reduction apparatus
JP2002504841A (en) 1997-06-21 2002-02-12 ハインドル・ハンス A bag surrounding at least part of the heart
WO1999000059A1 (en) * 1997-06-27 1999-01-07 The Trustees Of Columbia University In The City Of New York Method and apparatus for circulatory valve repair
FR2768324B1 (en) 1997-09-12 1999-12-10 Jacques Seguin SURGICAL INSTRUMENT FOR PERCUTANEOUSLY FIXING TWO AREAS OF SOFT TISSUE, NORMALLY MUTUALLY REMOTE, TO ONE ANOTHER
US6332893B1 (en) * 1997-12-17 2001-12-25 Myocor, Inc. Valve to myocardium tension members device and method
US6190408B1 (en) * 1998-03-05 2001-02-20 The University Of Cincinnati Device and method for restructuring the heart chamber geometry
US7491232B2 (en) 1998-09-18 2009-02-17 Aptus Endosystems, Inc. Catheter-based fastener implantation apparatus and methods with implantation force resolution
US6110100A (en) * 1998-04-22 2000-08-29 Scimed Life Systems, Inc. System for stress relieving the heart muscle and for controlling heart function
US7060021B1 (en) * 1998-07-23 2006-06-13 Wilk Patent Development Corporation Method and device for improving cardiac function
EP2111800B1 (en) 1998-07-29 2016-06-15 Edwards Lifesciences AG Transventricular implant tools and devices
US6260552B1 (en) 1998-07-29 2001-07-17 Myocor, Inc. Transventricular implant tools and devices
US8715156B2 (en) * 1998-10-09 2014-05-06 Swaminathan Jayaraman Modification of properties and geometry of heart tissue to influence function
US6685627B2 (en) 1998-10-09 2004-02-03 Swaminathan Jayaraman Modification of properties and geometry of heart tissue to influence heart function
US6587734B2 (en) 1998-11-04 2003-07-01 Acorn Cardiovascular, Inc. Cardio therapeutic heart sack
US6230714B1 (en) 1998-11-18 2001-05-15 Acorn Cardiovascular, Inc. Cardiac constraint with prior venus occlusion methods
US6169922B1 (en) 1998-11-18 2001-01-02 Acorn Cardiovascular, Inc. Defibrillating cardiac jacket with interwoven electrode grids
US6749598B1 (en) 1999-01-11 2004-06-15 Flowmedica, Inc. Apparatus and methods for treating congestive heart disease
US7780628B1 (en) 1999-01-11 2010-08-24 Angiodynamics, Inc. Apparatus and methods for treating congestive heart disease
US6155972A (en) * 1999-02-02 2000-12-05 Acorn Cardiovascular, Inc. Cardiac constraint jacket construction
US20040044350A1 (en) 1999-04-09 2004-03-04 Evalve, Inc. Steerable access sheath and methods of use
US10327743B2 (en) * 1999-04-09 2019-06-25 Evalve, Inc. Device and methods for endoscopic annuloplasty
US8216256B2 (en) 1999-04-09 2012-07-10 Evalve, Inc. Detachment mechanism for implantable fixation devices
US7811296B2 (en) 1999-04-09 2010-10-12 Evalve, Inc. Fixation devices for variation in engagement of tissue
US7563267B2 (en) 1999-04-09 2009-07-21 Evalve, Inc. Fixation device and methods for engaging tissue
US6752813B2 (en) 1999-04-09 2004-06-22 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
AU770243B2 (en) 1999-04-09 2004-02-19 Evalve, Inc. Methods and apparatus for cardiac valve repair
EP1176998B1 (en) 1999-05-04 2008-01-09 Simon Marcus Horner Cardiac assist apparatus
US7637905B2 (en) 2003-01-15 2009-12-29 Usgi Medical, Inc. Endoluminal tool deployment system
US7416554B2 (en) 2002-12-11 2008-08-26 Usgi Medical Inc Apparatus and methods for forming and securing gastrointestinal tissue folds
US8574243B2 (en) 1999-06-25 2013-11-05 Usgi Medical, Inc. Apparatus and methods for forming and securing gastrointestinal tissue folds
US7618426B2 (en) * 2002-12-11 2009-11-17 Usgi Medical, Inc. Apparatus and methods for forming gastrointestinal tissue approximations
US20040122456A1 (en) * 2002-12-11 2004-06-24 Saadat Vahid C. Methods and apparatus for gastric reduction
SE514718C2 (en) * 1999-06-29 2001-04-09 Jan Otto Solem Apparatus for treating defective closure of the mitral valve apparatus
US6997951B2 (en) * 1999-06-30 2006-02-14 Edwards Lifesciences Ag Method and device for treatment of mitral insufficiency
US6241654B1 (en) 1999-07-07 2001-06-05 Acorn Cardiovasculr, Inc. Cardiac reinforcement devices and methods
US7279007B2 (en) * 1999-08-09 2007-10-09 Cardioklnetix, Inc. Method for improving cardiac function
US9694121B2 (en) 1999-08-09 2017-07-04 Cardiokinetix, Inc. Systems and methods for improving cardiac function
US8377114B2 (en) * 1999-08-09 2013-02-19 Cardiokinetix, Inc. Sealing and filling ventricular partitioning devices to improve cardiac function
US7582051B2 (en) * 2005-06-10 2009-09-01 Cardiokinetix, Inc. Peripheral seal for a ventricular partitioning device
US20030109770A1 (en) * 1999-08-09 2003-06-12 Sharkey Hugh R. Device with a porous membrane for improving cardiac function
US8257428B2 (en) * 1999-08-09 2012-09-04 Cardiokinetix, Inc. System for improving cardiac function
US7674222B2 (en) * 1999-08-09 2010-03-09 Cardiokinetix, Inc. Cardiac device and methods of use thereof
US10307147B2 (en) 1999-08-09 2019-06-04 Edwards Lifesciences Corporation System for improving cardiac function by sealing a partitioning membrane within a ventricle
US20060229491A1 (en) * 2002-08-01 2006-10-12 Cardiokinetix, Inc. Method for treating myocardial rupture
US8246671B2 (en) 1999-08-09 2012-08-21 Cardiokinetix, Inc. Retrievable cardiac devices
US8529430B2 (en) 2002-08-01 2013-09-10 Cardiokinetix, Inc. Therapeutic methods and devices following myocardial infarction
US7220281B2 (en) * 1999-08-18 2007-05-22 Intrinsic Therapeutics, Inc. Implant for reinforcing and annulus fibrosis
MXPA03003600A (en) * 1999-08-18 2004-12-02 Intrinsic Orthopedics Inc Devices and method for nucleus pulposus augmentation and retention.
US8323341B2 (en) * 2007-09-07 2012-12-04 Intrinsic Therapeutics, Inc. Impaction grafting for vertebral fusion
EP1624832A4 (en) * 1999-08-18 2008-12-24 Intrinsic Therapeutics Inc Devices and method for augmenting a vertebral disc nucleus
US7998213B2 (en) 1999-08-18 2011-08-16 Intrinsic Therapeutics, Inc. Intervertebral disc herniation repair
US7972337B2 (en) 2005-12-28 2011-07-05 Intrinsic Therapeutics, Inc. Devices and methods for bone anchoring
US7717961B2 (en) * 1999-08-18 2010-05-18 Intrinsic Therapeutics, Inc. Apparatus delivery in an intervertebral disc
WO2009033100A1 (en) * 2007-09-07 2009-03-12 Intrinsic Therapeutics, Inc. Bone anchoring systems
US7553329B2 (en) * 1999-08-18 2009-06-30 Intrinsic Therapeutics, Inc. Stabilized intervertebral disc barrier
US6193648B1 (en) 1999-09-21 2001-02-27 Acorn Cardiovascular, Inc. Cardiac constraint with draw string tensioning
US6179791B1 (en) 1999-09-21 2001-01-30 Acorn Cardiovascular, Inc. Device for heart measurement
US6174279B1 (en) 1999-09-21 2001-01-16 Acorn Cardiovascular, Inc. Cardiac constraint with tension indicator
US6702732B1 (en) 1999-12-22 2004-03-09 Paracor Surgical, Inc. Expandable cardiac harness for treating congestive heart failure
EP1113497A3 (en) * 1999-12-29 2006-01-25 Texas Instruments Incorporated Semiconductor package with conductor impedance selected during assembly
US6293906B1 (en) 2000-01-14 2001-09-25 Acorn Cardiovascular, Inc. Delivery of cardiac constraint jacket
US6989028B2 (en) 2000-01-31 2006-01-24 Edwards Lifesciences Ag Medical system and method for remodeling an extravascular tissue structure
US6402781B1 (en) 2000-01-31 2002-06-11 Mitralife Percutaneous mitral annuloplasty and cardiac reinforcement
US7296577B2 (en) * 2000-01-31 2007-11-20 Edwards Lifescience Ag Transluminal mitral annuloplasty with active anchoring
EP1261294B1 (en) 2000-03-10 2006-11-29 Paracor Medical, Inc. Expandable cardiac harness for treating congestive heart failure
US6537198B1 (en) * 2000-03-21 2003-03-25 Myocor, Inc. Splint assembly for improving cardiac function in hearts, and method for implanting the splint assembly
ITPC20000013A1 (en) 2000-04-13 2000-07-13 Paolo Ferrazzi INTROVENTRICULAR DEVICE AND RELATED METHOD FOR THE TREATMENT AND CORRECTION OF MYOCARDIOPATHIES.
US6425856B1 (en) 2000-05-10 2002-07-30 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
US20030023132A1 (en) * 2000-05-31 2003-01-30 Melvin David B. Cyclic device for restructuring heart chamber geometry
US6730016B1 (en) 2000-06-12 2004-05-04 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
US20050095268A1 (en) * 2000-06-12 2005-05-05 Acorn Cardiovascular, Inc. Cardiac wall tension relief with cell loss management
US6902522B1 (en) 2000-06-12 2005-06-07 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
US7618364B2 (en) * 2000-06-12 2009-11-17 Acorn Cardiovascular, Inc. Cardiac wall tension relief device and method
US6951534B2 (en) 2000-06-13 2005-10-04 Acorn Cardiovascular, Inc. Cardiac support device
US6482146B1 (en) 2000-06-13 2002-11-19 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
US6343605B1 (en) * 2000-08-08 2002-02-05 Scimed Life Systems, Inc. Percutaneous transluminal myocardial implantation device and method
US8398537B2 (en) * 2005-06-10 2013-03-19 Cardiokinetix, Inc. Peripheral seal for a ventricular partitioning device
US9078660B2 (en) * 2000-08-09 2015-07-14 Cardiokinetix, Inc. Devices and methods for delivering an endocardial device
US20060030881A1 (en) * 2004-08-05 2006-02-09 Cardiokinetix, Inc. Ventricular partitioning device
US9332992B2 (en) 2004-08-05 2016-05-10 Cardiokinetix, Inc. Method for making a laminar ventricular partitioning device
US7762943B2 (en) * 2004-03-03 2010-07-27 Cardiokinetix, Inc. Inflatable ventricular partitioning device
US9332993B2 (en) 2004-08-05 2016-05-10 Cardiokinetix, Inc. Devices and methods for delivering an endocardial device
US7862500B2 (en) * 2002-08-01 2011-01-04 Cardiokinetix, Inc. Multiple partitioning devices for heart treatment
US7399271B2 (en) * 2004-01-09 2008-07-15 Cardiokinetix, Inc. Ventricular partitioning device
US10064696B2 (en) 2000-08-09 2018-09-04 Edwards Lifesciences Corporation Devices and methods for delivering an endocardial device
US6572533B1 (en) 2000-08-17 2003-06-03 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
US6887192B1 (en) 2000-09-08 2005-05-03 Converge Medical, Inc. Heart support to prevent ventricular remodeling
US7691144B2 (en) 2003-10-01 2010-04-06 Mvrx, Inc. Devices, systems, and methods for reshaping a heart valve annulus
US20060106278A1 (en) * 2004-05-14 2006-05-18 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus, including the use of an adjustable bridge implant system
WO2004030568A2 (en) * 2002-10-01 2004-04-15 Ample Medical, Inc. Device and method for repairing a native heart valve leaflet
US20090287179A1 (en) 2003-10-01 2009-11-19 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
US6893459B1 (en) * 2000-09-20 2005-05-17 Ample Medical, Inc. Heart valve annulus device and method of using same
US20050228422A1 (en) * 2002-11-26 2005-10-13 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
WO2004030570A2 (en) * 2002-10-01 2004-04-15 Ample Medical, Inc. Devices for retaining native heart valve leaflet
US20060106279A1 (en) 2004-05-14 2006-05-18 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus, including the use of a bridge implant having an adjustable bridge stop
US20080091264A1 (en) 2002-11-26 2008-04-17 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
US8784482B2 (en) * 2000-09-20 2014-07-22 Mvrx, Inc. Method of reshaping a heart valve annulus using an intravascular device
US8956407B2 (en) * 2000-09-20 2015-02-17 Mvrx, Inc. Methods for reshaping a heart valve annulus using a tensioning implant
US6808483B1 (en) * 2000-10-03 2004-10-26 Paul A. Spence Implantable heart assist devices and methods
US6616684B1 (en) * 2000-10-06 2003-09-09 Myocor, Inc. Endovascular splinting devices and methods
US6723038B1 (en) 2000-10-06 2004-04-20 Myocor, Inc. Methods and devices for improving mitral valve function
US6673009B1 (en) * 2000-11-08 2004-01-06 Acorn Cardiovascular, Inc. Adjustment clamp
US6564094B2 (en) 2000-12-22 2003-05-13 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
US20020161382A1 (en) * 2001-03-29 2002-10-31 Neisz Johann J. Implant inserted without bone anchors
US7510576B2 (en) * 2001-01-30 2009-03-31 Edwards Lifesciences Ag Transluminal mitral annuloplasty
US6810882B2 (en) 2001-01-30 2004-11-02 Ev3 Santa Rosa, Inc. Transluminal mitral annuloplasty
US6575921B2 (en) 2001-02-09 2003-06-10 Acorn Cardiovascular, Inc. Device for heart measurement
US6702763B2 (en) * 2001-02-28 2004-03-09 Chase Medical, L.P. Sizing apparatus and method for use during ventricular restoration
US20020133227A1 (en) * 2001-02-28 2002-09-19 Gregory Murphy Ventricular restoration patch apparatus and method of use
US20030181940A1 (en) * 2001-02-28 2003-09-25 Gregory Murphy Ventricular restoration shaping apparatus and method of use
US6622730B2 (en) 2001-03-30 2003-09-23 Myocor, Inc. Device for marking and aligning positions on the heart
US6923646B2 (en) * 2001-04-18 2005-08-02 Air Techniques, Inc. Process and apparatus for treating an exhaust stream from a dental operatory
US20060069429A1 (en) * 2001-04-24 2006-03-30 Spence Paul A Tissue fastening systems and methods utilizing magnetic guidance
US8202315B2 (en) 2001-04-24 2012-06-19 Mitralign, Inc. Catheter-based annuloplasty using ventricularly positioned catheter
US6619291B2 (en) * 2001-04-24 2003-09-16 Edwin J. Hlavka Method and apparatus for catheter-based annuloplasty
US7346394B2 (en) * 2001-04-27 2008-03-18 Cardiac Pacemakers, Inc. Cardiac stimulation at high ventricular wall stress areas
US7338514B2 (en) 2001-06-01 2008-03-04 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods and tools, and related methods of use
US20040243170A1 (en) * 2001-09-05 2004-12-02 Mitta Suresh Method and device for percutaneous surgical ventricular repair
US7485088B2 (en) 2001-09-05 2009-02-03 Chase Medical L.P. Method and device for percutaneous surgical ventricular repair
WO2003022131A2 (en) * 2001-09-07 2003-03-20 Mardil, Inc. Method and apparatus for external heart stabilization
WO2003022176A2 (en) * 2001-09-10 2003-03-20 Paracor Medical, Inc. Cardiac harness
US6695769B2 (en) 2001-09-25 2004-02-24 The Foundry, Inc. Passive ventricular support devices and methods of using them
US6685620B2 (en) * 2001-09-25 2004-02-03 The Foundry Inc. Ventricular infarct assist device and methods for using it
US7060023B2 (en) * 2001-09-25 2006-06-13 The Foundry Inc. Pericardium reinforcing devices and methods of using them
JP4458845B2 (en) 2001-10-01 2010-04-28 アンプル メディカル,インコーポレイテッド Medical device
US7144363B2 (en) * 2001-10-16 2006-12-05 Extensia Medical, Inc. Systems for heart treatment
EP1446069A1 (en) * 2001-10-31 2004-08-18 Paracor Surgical, Inc. Heart failure treatment device
US7635387B2 (en) 2001-11-01 2009-12-22 Cardiac Dimensions, Inc. Adjustable height focal tissue deflector
US6824562B2 (en) 2002-05-08 2004-11-30 Cardiac Dimensions, Inc. Body lumen device anchor, device and assembly
US6575971B2 (en) * 2001-11-15 2003-06-10 Quantum Cor, Inc. Cardiac valve leaflet stapler device and methods thereof
US20110087320A1 (en) * 2001-11-28 2011-04-14 Aptus Endosystems, Inc. Devices, Systems, and Methods for Prosthesis Delivery and Implantation, Including a Prosthesis Assembly
US20070073389A1 (en) 2001-11-28 2007-03-29 Aptus Endosystems, Inc. Endovascular aneurysm devices, systems, and methods
US9320503B2 (en) 2001-11-28 2016-04-26 Medtronic Vascular, Inc. Devices, system, and methods for guiding an operative tool into an interior body region
US20090099650A1 (en) * 2001-11-28 2009-04-16 Lee Bolduc Devices, systems, and methods for endovascular staple and/or prosthesis delivery and implantation
US8231639B2 (en) 2001-11-28 2012-07-31 Aptus Endosystems, Inc. Systems and methods for attaching a prosthesis within a body lumen or hollow organ
EP1448117B1 (en) 2001-11-28 2013-05-22 Aptus Endosystems, Inc. Endovascular aneurysm repair system
US20050177180A1 (en) * 2001-11-28 2005-08-11 Aptus Endosystems, Inc. Devices, systems, and methods for supporting tissue and/or structures within a hollow body organ
US6976995B2 (en) 2002-01-30 2005-12-20 Cardiac Dimensions, Inc. Fixed length anchor and pull mitral valve device and method
US7174896B1 (en) 2002-01-07 2007-02-13 Paracor Medical, Inc. Method and apparatus for supporting a heart
US7022063B2 (en) 2002-01-07 2006-04-04 Paracor Medical, Inc. Cardiac harness
US6764510B2 (en) 2002-01-09 2004-07-20 Myocor, Inc. Devices and methods for heart valve treatment
US20030225420A1 (en) 2002-03-11 2003-12-04 Wardle John L. Surgical coils and methods of deploying
US7181272B2 (en) 2002-04-22 2007-02-20 Medtronic, Inc. Cardiac restraint with electrode attachment sites
CA2483905C (en) 2002-05-09 2011-01-25 Tyco Healthcare Group Lp Endoscopic organ retractor and method of using the same
EP1503678B1 (en) * 2002-05-09 2010-01-20 Tyco Healthcare Group Lp Organ retractor
US20040010180A1 (en) * 2002-05-16 2004-01-15 Scorvo Sean K. Cardiac assist system
US7274876B2 (en) * 2002-06-06 2007-09-25 At&T Corp. Integrated electrical/optical hybrid communication system with revertive hitless switch
US6682475B2 (en) 2002-06-11 2004-01-27 Acorn Cardiovascular, Inc. Tension indicator for cardiac support device and method therefore
US20030233022A1 (en) * 2002-06-12 2003-12-18 Vidlund Robert M. Devices and methods for heart valve treatment
US8641727B2 (en) 2002-06-13 2014-02-04 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US20060122633A1 (en) 2002-06-13 2006-06-08 John To Methods and devices for termination
US7753858B2 (en) * 2002-06-13 2010-07-13 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US7883538B2 (en) * 2002-06-13 2011-02-08 Guided Delivery Systems Inc. Methods and devices for termination
AU2003245507A1 (en) * 2002-06-13 2003-12-31 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US7753922B2 (en) * 2003-09-04 2010-07-13 Guided Delivery Systems, Inc. Devices and methods for cardiac annulus stabilization and treatment
US9949829B2 (en) 2002-06-13 2018-04-24 Ancora Heart, Inc. Delivery devices and methods for heart valve repair
US8287555B2 (en) * 2003-02-06 2012-10-16 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US20040243227A1 (en) * 2002-06-13 2004-12-02 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US7753924B2 (en) 2003-09-04 2010-07-13 Guided Delivery Systems, Inc. Delivery devices and methods for heart valve repair
US7081084B2 (en) * 2002-07-16 2006-07-25 University Of Cincinnati Modular power system and method for a heart wall actuation system for the natural heart
US7850729B2 (en) 2002-07-18 2010-12-14 The University Of Cincinnati Deforming jacket for a heart actuation device
US20040059180A1 (en) * 2002-09-23 2004-03-25 The University Of Cincinnati Basal mounting cushion frame component to facilitate extrinsic heart wall actuation
US20040015041A1 (en) * 2002-07-18 2004-01-22 The University Of Cincinnati Protective sheath apparatus and method for use with a heart wall actuation system for the natural heart
AU2003261252A1 (en) * 2002-07-26 2004-02-16 Myomend, Inc. Cardiac rhythm management system with intramural myocardial pacing leads and electrodes
US20040242956A1 (en) * 2002-07-29 2004-12-02 Scorvo Sean K. System for controlling fluid in a body
US6988982B2 (en) * 2002-08-19 2006-01-24 Cardioenergetics Heart wall actuation system for the natural heart with shape limiting elements
US7485089B2 (en) * 2002-09-05 2009-02-03 Paracor Medical, Inc. Cardiac harness
US7063679B2 (en) * 2002-09-20 2006-06-20 Flowmedica, Inc. Intra-aortic renal delivery catheter
US7993325B2 (en) 2002-09-20 2011-08-09 Angio Dynamics, Inc. Renal infusion systems and methods
AU2003276903A1 (en) 2002-09-20 2004-05-04 Flowmedica, Inc. Method and apparatus for selective material delivery via an intra-renal catheter
EP1585572A4 (en) 2002-09-20 2010-02-24 Flowmedica Inc Method and apparatus for intra aortic substance delivery to a branch vessel
EP1562522B1 (en) * 2002-10-01 2008-12-31 Ample Medical, Inc. Devices and systems for reshaping a heart valve annulus
EP1565111B1 (en) * 2002-10-04 2011-03-23 Tyco Healthcare Group LP Endoscopic retractor
US7087064B1 (en) * 2002-10-15 2006-08-08 Advanced Cardiovascular Systems, Inc. Apparatuses and methods for heart valve repair
US8979923B2 (en) 2002-10-21 2015-03-17 Mitralign, Inc. Tissue fastening systems and methods utilizing magnetic guidance
BR0315392A (en) * 2002-10-21 2005-08-23 Mitralign Inc Incrementing catheters and methods of performing annuloplasty
US7112219B2 (en) 2002-11-12 2006-09-26 Myocor, Inc. Devices and methods for heart valve treatment
US7247134B2 (en) 2002-11-12 2007-07-24 Myocor, Inc. Devices and methods for heart valve treatment
US20070255093A1 (en) * 2002-11-15 2007-11-01 Lilip Lau Cardiac harness delivery device and method
US7331972B1 (en) 2002-11-15 2008-02-19 Abbott Cardiovascular Systems Inc. Heart valve chord cutter
US20050059855A1 (en) * 2002-11-15 2005-03-17 Lilip Lau Cardiac harness delivery device and method
US7736299B2 (en) * 2002-11-15 2010-06-15 Paracor Medical, Inc. Introducer for a cardiac harness delivery
US9149602B2 (en) 2005-04-22 2015-10-06 Advanced Cardiovascular Systems, Inc. Dual needle delivery system
US8187324B2 (en) 2002-11-15 2012-05-29 Advanced Cardiovascular Systems, Inc. Telescoping apparatus for delivering and adjusting a medical device in a vessel
US7335213B1 (en) 2002-11-15 2008-02-26 Abbott Cardiovascular Systems Inc. Apparatus and methods for heart valve repair
US20040098116A1 (en) 2002-11-15 2004-05-20 Callas Peter L. Valve annulus constriction apparatus and method
US7404824B1 (en) * 2002-11-15 2008-07-29 Advanced Cardiovascular Systems, Inc. Valve aptation assist device
US7485143B2 (en) * 2002-11-15 2009-02-03 Abbott Cardiovascular Systems Inc. Apparatuses and methods for heart valve repair
CA2504555C (en) * 2002-11-15 2012-09-04 Paracor Medical, Inc. Cardiac harness delivery device
US7981152B1 (en) 2004-12-10 2011-07-19 Advanced Cardiovascular Systems, Inc. Vascular delivery system for accessing and delivering devices into coronary sinus and other vascular sites
US6945978B1 (en) 2002-11-15 2005-09-20 Advanced Cardiovascular Systems, Inc. Heart valve catheter
US7942884B2 (en) 2002-12-11 2011-05-17 Usgi Medical, Inc. Methods for reduction of a gastric lumen
US7942898B2 (en) 2002-12-11 2011-05-17 Usgi Medical, Inc. Delivery systems and methods for gastric reduction
US6984242B2 (en) * 2002-12-20 2006-01-10 Gore Enterprise Holdings, Inc. Implantable medical device assembly
US7883500B2 (en) * 2003-03-26 2011-02-08 G&L Consulting, Llc Method and system to treat and prevent myocardial infarct expansion
US20050283042A1 (en) * 2003-03-28 2005-12-22 Steve Meyer Cardiac harness having radiopaque coating and method of use
US20040249242A1 (en) * 2003-03-28 2004-12-09 Lilip Lau Multi-panel cardiac harness
US20040220654A1 (en) 2003-05-02 2004-11-04 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US10667823B2 (en) 2003-05-19 2020-06-02 Evalve, Inc. Fixation devices, systems and methods for engaging tissue
US7341584B1 (en) 2003-05-30 2008-03-11 Thomas David Starkey Device and method to limit filling of the heart
JP2006526464A (en) 2003-06-05 2006-11-24 フローメディカ,インコーポレイテッド System and method for performing bilateral intervention or diagnosis in a branched body lumen
US7887582B2 (en) * 2003-06-05 2011-02-15 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
WO2004110257A2 (en) 2003-06-09 2004-12-23 The University Of Cincinnati Power system for a heart actuation device
WO2004110553A1 (en) 2003-06-09 2004-12-23 The University Of Cincinnati Actuation mechanisms for a heart actuation device
US20060178551A1 (en) * 2003-06-09 2006-08-10 Melvin David B Securement system for a heart actuation device
US7316706B2 (en) * 2003-06-20 2008-01-08 Medtronic Vascular, Inc. Tensioning device, system, and method for treating mitral valve regurgitation
JP2007528749A (en) * 2003-07-10 2007-10-18 パラコー メディカル インコーポレイテッド Self-fixing cardiac harness
US7513867B2 (en) * 2003-07-16 2009-04-07 Kardium, Inc. Methods and devices for altering blood flow through the left ventricle
US8216252B2 (en) 2004-05-07 2012-07-10 Usgi Medical, Inc. Tissue manipulation and securement system
US7235042B2 (en) 2003-09-16 2007-06-26 Acorn Cardiovascular, Inc. Apparatus and method for applying cardiac support device
US7998112B2 (en) 2003-09-30 2011-08-16 Abbott Cardiovascular Systems Inc. Deflectable catheter assembly and method of making same
US7155295B2 (en) * 2003-11-07 2006-12-26 Paracor Medical, Inc. Cardiac harness for treating congestive heart failure and for defibrillating and/or pacing/sensing
US20050137673A1 (en) * 2003-11-07 2005-06-23 Lilip Lau Cardiac harness having electrodes and epicardial leads
US20050171589A1 (en) * 2003-11-07 2005-08-04 Lilip Lau Cardiac harness and method of delivery by minimally invasive access
US20070106336A1 (en) * 2003-11-07 2007-05-10 Alan Schaer Cardiac harness assembly for treating congestive heart failure and for pacing/sensing
US7158839B2 (en) * 2003-11-07 2007-01-02 Paracor Medical, Inc. Cardiac harness for treating heart disease
US20070055091A1 (en) * 2004-12-02 2007-03-08 Lilip Lau Cardiac harness for treating congestive heart failure and for defibrillating and/or pacing/sensing
US20070106359A1 (en) * 2003-11-07 2007-05-10 Alan Schaer Cardiac harness assembly for treating congestive heart failure and for pacing/sensing
US7361180B2 (en) * 2004-05-07 2008-04-22 Usgi Medical, Inc. Apparatus for manipulating and securing tissue
US7347863B2 (en) * 2004-05-07 2008-03-25 Usgi Medical, Inc. Apparatus and methods for manipulating and securing tissue
US20050251189A1 (en) * 2004-05-07 2005-11-10 Usgi Medical Inc. Multi-position tissue manipulation assembly
US20050273138A1 (en) * 2003-12-19 2005-12-08 Guided Delivery Systems, Inc. Devices and methods for anchoring tissue
US9526616B2 (en) 2003-12-19 2016-12-27 Cardiac Dimensions Pty. Ltd. Mitral valve annuloplasty device with twisted anchor
US20060271174A1 (en) * 2003-12-19 2006-11-30 Gregory Nieminen Mitral Valve Annuloplasty Device with Wide Anchor
US8864822B2 (en) 2003-12-23 2014-10-21 Mitralign, Inc. Devices and methods for introducing elements into tissue
US7431726B2 (en) 2003-12-23 2008-10-07 Mitralign, Inc. Tissue fastening systems and methods utilizing magnetic guidance
CA2553185A1 (en) * 2004-01-12 2005-08-04 Paracor Medical, Inc. Cardiac harness having interconnected strands
WO2005091910A2 (en) 2004-03-04 2005-10-06 Flowmedica, Inc. Sheath for use in peripheral interventions
US7703459B2 (en) 2004-03-09 2010-04-27 Usgi Medical, Inc. Apparatus and methods for mapping out endoluminal gastrointestinal surgery
WO2005087140A1 (en) 2004-03-11 2005-09-22 Percutaneous Cardiovascular Solutions Pty Limited Percutaneous heart valve prosthesis
US7255675B2 (en) * 2004-03-23 2007-08-14 Michael Gertner Devices and methods to treat a patient
US7172551B2 (en) * 2004-04-12 2007-02-06 Scimed Life Systems, Inc. Cyclical pressure coronary assist pump
EP1744679A2 (en) * 2004-05-03 2007-01-24 AMS Research Corporation Surgical implants and related methods
US8057511B2 (en) 2004-05-07 2011-11-15 Usgi Medical, Inc. Apparatus and methods for positioning and securing anchors
US7736374B2 (en) * 2004-05-07 2010-06-15 Usgi Medical, Inc. Tissue manipulation and securement system
US7390329B2 (en) * 2004-05-07 2008-06-24 Usgi Medical, Inc. Methods for grasping and cinching tissue anchors
US8444657B2 (en) 2004-05-07 2013-05-21 Usgi Medical, Inc. Apparatus and methods for rapid deployment of tissue anchors
US20050251208A1 (en) * 2004-05-07 2005-11-10 Usgi Medical Inc. Linear anchors for anchoring to tissue
US7918869B2 (en) 2004-05-07 2011-04-05 Usgi Medical, Inc. Methods and apparatus for performing endoluminal gastroplasty
US20050251176A1 (en) * 2004-05-07 2005-11-10 Usgi Medical Inc. System for treating gastroesophageal reflux disease
US20060135971A1 (en) * 2004-05-07 2006-06-22 Usgi Medical Inc. System for treating gastroesophageal reflux disease
US8257394B2 (en) * 2004-05-07 2012-09-04 Usgi Medical, Inc. Apparatus and methods for positioning and securing anchors
EP1750592B1 (en) 2004-05-14 2016-12-28 Evalve, Inc. Locking mechanisms for fixation devices
US7736379B2 (en) * 2004-06-09 2010-06-15 Usgi Medical, Inc. Compressible tissue anchor assemblies
US7695493B2 (en) * 2004-06-09 2010-04-13 Usgi Medical, Inc. System for optimizing anchoring force
US8206417B2 (en) * 2004-06-09 2012-06-26 Usgi Medical Inc. Apparatus and methods for optimizing anchoring force
US7678135B2 (en) 2004-06-09 2010-03-16 Usgi Medical, Inc. Compressible tissue anchor assemblies
US20060009675A1 (en) * 2004-07-08 2006-01-12 Steven Meyer Self-anchoring cardiac harness for treating the heart and for defibrillating and/or pacing/sensing
US7285087B2 (en) * 2004-07-15 2007-10-23 Micardia Corporation Shape memory devices and methods for reshaping heart anatomy
US7402134B2 (en) * 2004-07-15 2008-07-22 Micardia Corporation Magnetic devices and methods for reshaping heart anatomy
DE102004040135B3 (en) * 2004-08-19 2005-12-15 Abg Allgemeine Baumaschinen-Gesellschaft Mbh Self-propelled device for milling traffic areas
US7635329B2 (en) 2004-09-27 2009-12-22 Evalve, Inc. Methods and devices for tissue grasping and assessment
US8052592B2 (en) 2005-09-27 2011-11-08 Evalve, Inc. Methods and devices for tissue grasping and assessment
US20090326578A1 (en) * 2004-09-30 2009-12-31 Usgi Medical, Inc. Interlocking tissue anchor apparatus and methods
US20060079736A1 (en) 2004-10-13 2006-04-13 Sing-Fatt Chin Method and device for percutaneous left ventricular reconstruction
US20060089711A1 (en) * 2004-10-27 2006-04-27 Medtronic Vascular, Inc. Multifilament anchor for reducing a compass of a lumen or structure in mammalian body
US20060135970A1 (en) 2004-11-15 2006-06-22 Laurent Schaller Catheter-based tissue remodeling devices and methods
WO2006055820A2 (en) * 2004-11-19 2006-05-26 G & L Consulting Llc Biodegradable pericardial constraint system and method
US20060129026A1 (en) * 2004-12-15 2006-06-15 Joshua Wallin Apparatus and method for mounting a cardiac harness on the heart
US8060219B2 (en) 2004-12-20 2011-11-15 Cardiac Pacemakers, Inc. Epicardial patch including isolated extracellular matrix with pacing electrodes
US7981065B2 (en) * 2004-12-20 2011-07-19 Cardiac Pacemakers, Inc. Lead electrode incorporating extracellular matrix
US7731705B2 (en) 2005-01-10 2010-06-08 Wardle John L Eluting coils and methods of deploying and retrieving
JP4926980B2 (en) 2005-01-20 2012-05-09 カーディアック ディメンションズ インコーポレイテッド Tissue shaping device
EP1845861B1 (en) 2005-01-21 2011-06-22 Mayo Foundation for Medical Education and Research Thorascopic heart valve repair apparatus
US8470028B2 (en) 2005-02-07 2013-06-25 Evalve, Inc. Methods, systems and devices for cardiac valve repair
EP3967269A3 (en) 2005-02-07 2022-07-13 Evalve, Inc. Systems and devices for cardiac valve repair
US20060189840A1 (en) * 2005-02-18 2006-08-24 Acorn Cardiovascular, Inc. Transmyocardial delivery of cardiac wall tension relief
US7320665B2 (en) 2005-03-02 2008-01-22 Venkataramana Vijay Cardiac Ventricular Geometry Restoration Device and Treatment for Heart Failure
US20060199995A1 (en) * 2005-03-02 2006-09-07 Venkataramana Vijay Percutaneous cardiac ventricular geometry restoration device and treatment for heart failure
US8608797B2 (en) 2005-03-17 2013-12-17 Valtech Cardio Ltd. Mitral valve treatment techniques
US10219902B2 (en) 2005-03-25 2019-03-05 Mvrx, Inc. Devices, systems, and methods for reshaping a heart valve anulus, including the use of a bridge implant having an adjustable bridge stop
JP2008534084A (en) * 2005-03-25 2008-08-28 アンプル メディカル, インコーポレイテッド Apparatus, system, and method for reshaping a heart valve annulus
US8333777B2 (en) 2005-04-22 2012-12-18 Benvenue Medical, Inc. Catheter-based tissue remodeling devices and methods
US8109866B2 (en) * 2005-04-26 2012-02-07 Ams Research Corporation Method and apparatus for prolapse repair
US20060247491A1 (en) * 2005-04-27 2006-11-02 Vidlund Robert M Devices and methods for heart valve treatment
US8298291B2 (en) 2005-05-26 2012-10-30 Usgi Medical, Inc. Methods and apparatus for securing and deploying tissue anchors
US9585651B2 (en) 2005-05-26 2017-03-07 Usgi Medical, Inc. Methods and apparatus for securing and deploying tissue anchors
US7621866B2 (en) * 2005-05-31 2009-11-24 Ethicon, Inc. Method and device for deployment of a sub-pericardial sack
US7766816B2 (en) 2005-06-09 2010-08-03 Chf Technologies, Inc. Method and apparatus for closing off a portion of a heart ventricle
US8951285B2 (en) 2005-07-05 2015-02-10 Mitralign, Inc. Tissue anchor, anchoring system and methods of using the same
US20070032696A1 (en) * 2005-07-22 2007-02-08 Sieu Duong Cardiac harness delivery device
JP4376836B2 (en) * 2005-07-29 2009-12-02 富士フイルム株式会社 Magnetic recording device
US7587247B2 (en) * 2005-08-01 2009-09-08 Paracor Medical, Inc. Cardiac harness having an optimal impedance range
US20070055206A1 (en) * 2005-08-10 2007-03-08 Guided Delivery Systems, Inc. Methods and devices for deployment of tissue anchors
US20070043416A1 (en) * 2005-08-19 2007-02-22 Cardiac Pacemakers, Inc. Implantable electrode array
WO2007022519A2 (en) 2005-08-19 2007-02-22 Chf Technologies, Inc. Steerable heart implants for congestive heart failure
US8506474B2 (en) 2005-08-19 2013-08-13 Bioventrix, Inc. Method and device for treating dysfunctional cardiac tissue
US20070078297A1 (en) * 2005-08-31 2007-04-05 Medtronic Vascular, Inc. Device for Treating Mitral Valve Regurgitation
US7715918B2 (en) 2005-10-18 2010-05-11 University Of Cincinnati Muscle energy converter with smooth continuous tissue interface
CN101466316B (en) 2005-10-20 2012-06-27 阿普特斯内系统公司 Devices systems and methods for prosthesis delivery and implantation including the use of a fastener tool
EP1968492A2 (en) * 2005-12-15 2008-09-17 Georgia Technology Research Corporation Systems and methods to control the dimension of a heart valve
US8568473B2 (en) * 2005-12-15 2013-10-29 Georgia Tech Research Corporation Systems and methods for enabling heart valve replacement
US9125742B2 (en) * 2005-12-15 2015-09-08 Georgia Tech Research Foundation Papillary muscle position control devices, systems, and methods
US8726909B2 (en) 2006-01-27 2014-05-20 Usgi Medical, Inc. Methods and apparatus for revision of obesity procedures
US20070233219A1 (en) * 2006-02-16 2007-10-04 Bilal Shafi Polymeric heart restraint
US7749249B2 (en) 2006-02-21 2010-07-06 Kardium Inc. Method and device for closing holes in tissue
US20070203391A1 (en) * 2006-02-24 2007-08-30 Medtronic Vascular, Inc. System for Treating Mitral Valve Regurgitation
US20070208217A1 (en) * 2006-03-03 2007-09-06 Acorn Cardiovascular, Inc. Self-adjusting attachment structure for a cardiac support device
US7727142B2 (en) 2006-03-03 2010-06-01 Acorn Cardiovascular, Inc. Delivery tool for cardiac support device
JP5148598B2 (en) 2006-05-03 2013-02-20 ラプトール リッジ, エルエルシー Tissue closure system and method
US20070265658A1 (en) * 2006-05-12 2007-11-15 Aga Medical Corporation Anchoring and tethering system
US20070270654A1 (en) * 2006-05-19 2007-11-22 Acorn Cardiovascular, Inc. Pericardium management tool for intra-pericardial surgical procedures
US20070287883A1 (en) * 2006-06-07 2007-12-13 Lilip Lau Apparatus and method for pulling a cardiac harness onto a heart
US7771401B2 (en) 2006-06-08 2010-08-10 Angiodynamics, Inc. Selective renal cannulation and infusion systems and methods
DE102006028964A1 (en) * 2006-06-16 2007-12-20 Eberhard-Karls-Universität Tübingen Device for the treatment of mitral valve insufficiency
US8449605B2 (en) 2006-06-28 2013-05-28 Kardium Inc. Method for anchoring a mitral valve
US20080004488A1 (en) * 2006-06-29 2008-01-03 Acorn Cardiovascular, Inc. Low friction delivery tool for a cardiac support device
US7877142B2 (en) * 2006-07-05 2011-01-25 Micardia Corporation Methods and systems for cardiac remodeling via resynchronization
US8870916B2 (en) 2006-07-07 2014-10-28 USGI Medical, Inc Low profile tissue anchors, tissue anchor systems, and methods for their delivery and use
US11285005B2 (en) 2006-07-17 2022-03-29 Cardiac Dimensions Pty. Ltd. Mitral valve annuloplasty device with twisted anchor
US7651462B2 (en) 2006-07-17 2010-01-26 Acorn Cardiovascular, Inc. Cardiac support device delivery tool with release mechanism
US7837610B2 (en) 2006-08-02 2010-11-23 Kardium Inc. System for improving diastolic dysfunction
US7641608B1 (en) 2006-09-26 2010-01-05 Acorn Cardiovascular, Inc. Sectional cardiac support device and method of delivery
US9211115B2 (en) 2006-09-28 2015-12-15 Bioventrix, Inc. Location, time, and/or pressure determining devices, systems, and methods for deployment of lesion-excluding heart implants for treatment of cardiac heart failure and other disease states
US8123668B2 (en) 2006-09-28 2012-02-28 Bioventrix (A Chf Technologies' Company) Signal transmitting and lesion excluding heart implants for pacing defibrillating and/or sensing of heart beat
US20080091057A1 (en) * 2006-10-11 2008-04-17 Cardiac Pacemakers, Inc. Method and apparatus for passive left atrial support
US8388680B2 (en) * 2006-10-18 2013-03-05 Guided Delivery Systems, Inc. Methods and devices for catheter advancement and delivery of substances therethrough
US20110257723A1 (en) 2006-11-07 2011-10-20 Dc Devices, Inc. Devices and methods for coronary sinus pressure relief
US9232997B2 (en) 2006-11-07 2016-01-12 Corvia Medical, Inc. Devices and methods for retrievable intra-atrial implants
US8460372B2 (en) 2006-11-07 2013-06-11 Dc Devices, Inc. Prosthesis for reducing intra-cardiac pressure having an embolic filter
US10413284B2 (en) 2006-11-07 2019-09-17 Corvia Medical, Inc. Atrial pressure regulation with control, sensing, monitoring and therapy delivery
CA2664557C (en) 2006-11-07 2015-05-26 David Stephen Celermajer Devices and methods for the treatment of heart failure
JP2010511469A (en) * 2006-12-05 2010-04-15 バルテック カーディオ,リミティド Segmented ring placement
US9883943B2 (en) 2006-12-05 2018-02-06 Valtech Cardio, Ltd. Implantation of repair devices in the heart
WO2010004546A1 (en) 2008-06-16 2010-01-14 Valtech Cardio, Ltd. Annuloplasty devices and methods of delivery therefor
US11259924B2 (en) 2006-12-05 2022-03-01 Valtech Cardio Ltd. Implantation of repair devices in the heart
US20080177380A1 (en) * 2007-01-19 2008-07-24 Starksen Niel F Methods and devices for heart tissue repair
EP3345572A1 (en) 2007-02-14 2018-07-11 Edwards Lifesciences Corporation Suture and method for repairing heart
US8845723B2 (en) 2007-03-13 2014-09-30 Mitralign, Inc. Systems and methods for introducing elements into tissue
US8911461B2 (en) 2007-03-13 2014-12-16 Mitralign, Inc. Suture cutter and method of cutting suture
US11660190B2 (en) 2007-03-13 2023-05-30 Edwards Lifesciences Corporation Tissue anchors, systems and methods, and devices
CA2693198C (en) 2007-07-27 2014-10-14 Ams Research Corporation Pelvic floor treatments and related tools and implants
US20090048480A1 (en) * 2007-08-13 2009-02-19 Paracor Medical, Inc. Cardiac harness delivery device
US8192351B2 (en) 2007-08-13 2012-06-05 Paracor Medical, Inc. Medical device delivery system having integrated introducer
US8092363B2 (en) 2007-09-05 2012-01-10 Mardil, Inc. Heart band with fillable chambers to modify heart valve function
EP2194888B1 (en) * 2007-10-03 2021-04-28 Bioventrix, Inc. System for treating dysfunctional cardiac tissue
CA2703129C (en) 2007-10-18 2016-02-16 Neochord Inc. Minimially invasive repair of a valve leaflet in a beating heart
EP2217153B1 (en) * 2007-10-19 2021-03-03 Ancora Heart, Inc. Systems for cardiac remodeling
WO2009076209A1 (en) * 2007-12-05 2009-06-18 Surgical Energetics, Inc A bolster for securing a septal splint to a cardiac wall, a method of use thereof, and a system including the same
WO2009075800A1 (en) * 2007-12-07 2009-06-18 Ams Research Corporation Pelvic floor treatments and related tools and implants
US20090177028A1 (en) * 2008-01-04 2009-07-09 Anthony John White Non-blood contact cardiac compression device, for augmentation of cardiac function by timed cyclic tensioning of elastic cords in an epicardial location
WO2009100242A2 (en) 2008-02-06 2009-08-13 Guided Delivery Systems, Inc. Multi-window guide tunnel
US8382829B1 (en) 2008-03-10 2013-02-26 Mitralign, Inc. Method to reduce mitral regurgitation by cinching the commissure of the mitral valve
US8260395B2 (en) * 2008-04-18 2012-09-04 Medtronic, Inc. Method and apparatus for mapping a structure
US20090281372A1 (en) * 2008-05-06 2009-11-12 Paracor Medical, Inc. Cardiac harness assembly for treating congestive heart failure and for defibrillation and/or pacing/sensing
WO2009137712A1 (en) * 2008-05-07 2009-11-12 Guided Delivery Systems Inc. Deflectable guide
US20090287304A1 (en) 2008-05-13 2009-11-19 Kardium Inc. Medical Device for Constricting Tissue or a Bodily Orifice, for example a mitral valve
US8647254B2 (en) 2008-07-01 2014-02-11 Maquet Cardiovascular Llc Epicardial clip
US8425402B2 (en) * 2008-07-21 2013-04-23 Bioventrix, Inc. Cardiac anchor structures, methods, and systems for treatment of congestive heart failure and other conditions
EP2349019B1 (en) 2008-10-10 2020-03-25 Ancora Heart, Inc. Termination devices and related methods
CN102245110A (en) * 2008-10-10 2011-11-16 导向传输系统股份有限公司 Tether tensioning devices and related methods
CA2740867C (en) 2008-10-16 2018-06-12 Aptus Endosystems, Inc. Devices, systems, and methods for endovascular staple and/or prosthesis delivery and implantation
US8808368B2 (en) 2008-12-22 2014-08-19 Valtech Cardio, Ltd. Implantation of repair chords in the heart
US9011530B2 (en) 2008-12-22 2015-04-21 Valtech Cardio, Ltd. Partially-adjustable annuloplasty structure
US8545553B2 (en) 2009-05-04 2013-10-01 Valtech Cardio, Ltd. Over-wire rotation tool
US10517719B2 (en) 2008-12-22 2019-12-31 Valtech Cardio, Ltd. Implantation of repair devices in the heart
US8715342B2 (en) 2009-05-07 2014-05-06 Valtech Cardio, Ltd. Annuloplasty ring with intra-ring anchoring
US8147542B2 (en) 2008-12-22 2012-04-03 Valtech Cardio, Ltd. Adjustable repair chords and spool mechanism therefor
WO2010073246A2 (en) 2008-12-22 2010-07-01 Valtech Cardio, Ltd. Adjustable annuloplasty devices and adjustment mechanisms therefor
US8926697B2 (en) 2011-06-23 2015-01-06 Valtech Cardio, Ltd. Closed band for percutaneous annuloplasty
US8940044B2 (en) 2011-06-23 2015-01-27 Valtech Cardio, Ltd. Closure element for use with an annuloplasty structure
US8241351B2 (en) * 2008-12-22 2012-08-14 Valtech Cardio, Ltd. Adjustable partial annuloplasty ring and mechanism therefor
US9204965B2 (en) * 2009-01-14 2015-12-08 Lc Therapeutics, Inc. Synthetic chord
US20100198056A1 (en) * 2009-01-20 2010-08-05 Mariel Fabro Diagnostic catheters, guide catheters, visualization devices and chord manipulation devices, and related kits and methods
US20100198192A1 (en) 2009-01-20 2010-08-05 Eugene Serina Anchor deployment devices and related methods
US20100274227A1 (en) * 2009-02-13 2010-10-28 Alexander Khairkhahan Delivery catheter handle cover
US8353956B2 (en) * 2009-02-17 2013-01-15 Valtech Cardio, Ltd. Actively-engageable movement-restriction mechanism for use with an annuloplasty structure
WO2013069019A2 (en) 2011-11-08 2013-05-16 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool
US9968452B2 (en) 2009-05-04 2018-05-15 Valtech Cardio, Ltd. Annuloplasty ring delivery cathethers
US8523881B2 (en) 2010-07-26 2013-09-03 Valtech Cardio, Ltd. Multiple anchor delivery tool
US8449466B2 (en) 2009-05-28 2013-05-28 Edwards Lifesciences Corporation System and method for locating medical devices in vivo using ultrasound Doppler mode
CA2768027A1 (en) 2009-07-20 2011-01-27 Ams Research Corporation Devices, systems, and methods for delivering fluid to tissue
JP5489580B2 (en) * 2009-08-04 2014-05-14 キヤノン株式会社 Image forming apparatus and control method thereof
US9757107B2 (en) 2009-09-04 2017-09-12 Corvia Medical, Inc. Methods and devices for intra-atrial shunts having adjustable sizes
EP2633821B1 (en) 2009-09-15 2016-04-06 Evalve, Inc. Device for cardiac valve repair
WO2011041571A2 (en) 2009-10-01 2011-04-07 Kardium Inc. Medical device, kit and method for constricting tissue or a bodily orifice, for example, a mitral valve
WO2011056578A2 (en) 2009-10-26 2011-05-12 Cardiokinetix, Inc. Ventricular volume reduction
US8690939B2 (en) 2009-10-29 2014-04-08 Valtech Cardio, Ltd. Method for guide-wire based advancement of a rotation assembly
US8277502B2 (en) * 2009-10-29 2012-10-02 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
US9180007B2 (en) 2009-10-29 2015-11-10 Valtech Cardio, Ltd. Apparatus and method for guide-wire based advancement of an adjustable implant
US10098737B2 (en) 2009-10-29 2018-10-16 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
US9011520B2 (en) 2009-10-29 2015-04-21 Valtech Cardio, Ltd. Tissue anchor for annuloplasty device
EP2506777B1 (en) 2009-12-02 2020-11-25 Valtech Cardio, Ltd. Combination of spool assembly coupled to a helical anchor and delivery tool for implantation thereof
US8870950B2 (en) 2009-12-08 2014-10-28 Mitral Tech Ltd. Rotation-based anchoring of an implant
US10058323B2 (en) 2010-01-22 2018-08-28 4 Tech Inc. Tricuspid valve repair using tension
US8475525B2 (en) 2010-01-22 2013-07-02 4Tech Inc. Tricuspid valve repair using tension
US9307980B2 (en) 2010-01-22 2016-04-12 4Tech Inc. Tricuspid valve repair using tension
EP2528646A4 (en) 2010-01-29 2017-06-28 DC Devices, Inc. Devices and systems for treating heart failure
AU2011210741B2 (en) 2010-01-29 2013-08-15 Corvia Medical, Inc. Devices and methods for reducing venous pressure
US9107749B2 (en) 2010-02-03 2015-08-18 Edwards Lifesciences Corporation Methods for treating a heart
US9072603B2 (en) * 2010-02-24 2015-07-07 Medtronic Ventor Technologies, Ltd. Mitral prosthesis and methods for implantation
US8790394B2 (en) 2010-05-24 2014-07-29 Valtech Cardio, Ltd. Adjustable artificial chordeae tendineae with suture loops
US9050066B2 (en) 2010-06-07 2015-06-09 Kardium Inc. Closing openings in anatomical tissue
US11653910B2 (en) 2010-07-21 2023-05-23 Cardiovalve Ltd. Helical anchor implantation
US9861350B2 (en) 2010-09-03 2018-01-09 Ancora Heart, Inc. Devices and methods for anchoring tissue
US8940002B2 (en) 2010-09-30 2015-01-27 Kardium Inc. Tissue anchor system
EP2658480B1 (en) 2010-12-29 2017-11-01 Neochord Inc. Exchangeable system for minimally invasive beating heart repair of heart valve leaflets
CN103635226B (en) 2011-02-10 2017-06-30 可维亚媒体公司 Device for setting up and keeping intra-atrial pressure power release aperture
WO2012161769A1 (en) 2011-02-18 2012-11-29 Guided Delivery Systems Inc. Implant retrieval device
WO2012112967A1 (en) 2011-02-18 2012-08-23 Guided Delivery Systems Inc. Systems and methods for variable stiffness tethers
US9072511B2 (en) 2011-03-25 2015-07-07 Kardium Inc. Medical kit for constricting tissue or a bodily orifice, for example, a mitral valve
WO2012167120A2 (en) 2011-06-01 2012-12-06 Neochord, Inc. Minimally invasive repair of heart valve leaflets
US9918840B2 (en) 2011-06-23 2018-03-20 Valtech Cardio, Ltd. Closed band for percutaneous annuloplasty
US10792152B2 (en) 2011-06-23 2020-10-06 Valtech Cardio, Ltd. Closed band for percutaneous annuloplasty
US8945177B2 (en) 2011-09-13 2015-02-03 Abbott Cardiovascular Systems Inc. Gripper pusher mechanism for tissue apposition systems
US8900295B2 (en) 2011-09-26 2014-12-02 Edwards Lifesciences Corporation Prosthetic valve with ventricular tethers
BR112014007686A2 (en) 2011-09-30 2017-04-18 Bioventrix Inc method and system for heart treatment within the patient
US8858623B2 (en) 2011-11-04 2014-10-14 Valtech Cardio, Ltd. Implant having multiple rotational assemblies
WO2013096965A1 (en) 2011-12-22 2013-06-27 Dc Devices, Inc. Methods and devices for intra-atrial devices having selectable flow rates
US9005155B2 (en) 2012-02-03 2015-04-14 Dc Devices, Inc. Devices and methods for treating heart failure
US10076414B2 (en) 2012-02-13 2018-09-18 Mitraspan, Inc. Method and apparatus for repairing a mitral valve
AU2013221670A1 (en) 2012-02-13 2014-10-02 Mitraspan, Inc Method and apparatus for repairing a mitral valve
US9265514B2 (en) 2012-04-17 2016-02-23 Miteas Ltd. Manipulator for grasping tissue
US10588611B2 (en) 2012-04-19 2020-03-17 Corvia Medical Inc. Implant retention attachment and method of use
US9649480B2 (en) 2012-07-06 2017-05-16 Corvia Medical, Inc. Devices and methods of treating or ameliorating diastolic heart failure through pulmonary valve intervention
CA2885354A1 (en) 2012-09-29 2014-04-03 Mitralign, Inc. Plication lock delivery system and method of use thereof
EP2906151B1 (en) 2012-10-12 2023-06-21 Mardil, Inc. Cardiac treatment system
US10376266B2 (en) 2012-10-23 2019-08-13 Valtech Cardio, Ltd. Percutaneous tissue anchor techniques
EP3517052A1 (en) 2012-10-23 2019-07-31 Valtech Cardio, Ltd. Controlled steering functionality for implant-delivery tool
US9730793B2 (en) 2012-12-06 2017-08-15 Valtech Cardio, Ltd. Techniques for guide-wire based advancement of a tool
US9788948B2 (en) 2013-01-09 2017-10-17 4 Tech Inc. Soft tissue anchors and implantation techniques
US9681952B2 (en) 2013-01-24 2017-06-20 Mitraltech Ltd. Anchoring of prosthetic valve supports
WO2014134183A1 (en) 2013-02-26 2014-09-04 Mitralign, Inc. Devices and methods for percutaneous tricuspid valve repair
US9775636B2 (en) 2013-03-12 2017-10-03 Corvia Medical, Inc. Devices, systems, and methods for treating heart failure
US10617425B2 (en) 2014-03-10 2020-04-14 Conformal Medical, Inc. Devices and methods for excluding the left atrial appendage
WO2014164572A1 (en) 2013-03-13 2014-10-09 Kaplan Aaron V Devices and methods for excluding the left atrial appendage
US11399842B2 (en) 2013-03-13 2022-08-02 Conformal Medical, Inc. Devices and methods for excluding the left atrial appendage
US10449333B2 (en) 2013-03-14 2019-10-22 Valtech Cardio, Ltd. Guidewire feeder
CN105208978B (en) 2013-03-14 2016-12-07 4科技有限公司 There is the support of tether interface
WO2014159842A1 (en) * 2013-03-14 2014-10-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Devices and methods for treating functional tricuspid valve regurgitation
EP2968847B1 (en) 2013-03-15 2023-03-08 Edwards Lifesciences Corporation Translation catheter systems
CA2912653A1 (en) 2013-05-24 2014-11-27 Bioventrix, Inc. Cardiac tissue penetrating devices, methods, and systems for treatment of congestive heart failure and other conditions
EP3957252A1 (en) 2013-08-30 2022-02-23 Bioventrix, Inc. Heart anchor positioning devices, methods, and systems for treatment of congestive heart failure and other conditions
WO2015031647A2 (en) 2013-08-30 2015-03-05 Bioventrix, Inc. Cardiac tissue anchoring devices, methods, and systems for treatment of congestive heart failure and other conditions
US10070857B2 (en) 2013-08-31 2018-09-11 Mitralign, Inc. Devices and methods for locating and implanting tissue anchors at mitral valve commissure
USD717954S1 (en) 2013-10-14 2014-11-18 Mardil, Inc. Heart treatment device
US10299793B2 (en) 2013-10-23 2019-05-28 Valtech Cardio, Ltd. Anchor magazine
CA2925667A1 (en) * 2013-10-23 2015-04-30 Lc Therapeutics, Inc. Percutaneous or minimally invasive cardiac valve repair system and methods of using the same
US10052095B2 (en) 2013-10-30 2018-08-21 4Tech Inc. Multiple anchoring-point tension system
US10022114B2 (en) 2013-10-30 2018-07-17 4Tech Inc. Percutaneous tether locking
US10485545B2 (en) 2013-11-19 2019-11-26 Datascope Corp. Fastener applicator with interlock
US9610162B2 (en) 2013-12-26 2017-04-04 Valtech Cardio, Ltd. Implantation of flexible implant
US9730701B2 (en) 2014-01-16 2017-08-15 Boston Scientific Scimed, Inc. Retrieval wire centering device
US20170000935A1 (en) 2014-01-27 2017-01-05 Children's Medical Center Corporation Mechanical assist device
US10675450B2 (en) 2014-03-12 2020-06-09 Corvia Medical, Inc. Devices and methods for treating heart failure
US9572666B2 (en) 2014-03-17 2017-02-21 Evalve, Inc. Mitral valve fixation device removal devices and methods
US10390943B2 (en) 2014-03-17 2019-08-27 Evalve, Inc. Double orifice device for transcatheter mitral valve replacement
US9801720B2 (en) 2014-06-19 2017-10-31 4Tech Inc. Cardiac tissue cinching
US10632292B2 (en) 2014-07-23 2020-04-28 Corvia Medical, Inc. Devices and methods for treating heart failure
AU2015321690A1 (en) 2014-09-28 2017-03-23 Cardiokinetix, Inc. Apparatuses for treating cardiac dysfunction
WO2016059639A1 (en) 2014-10-14 2016-04-21 Valtech Cardio Ltd. Leaflet-restraining techniques
JP6717820B2 (en) 2014-12-02 2020-07-08 4テック インコーポレイテッド Eccentric tissue anchor
US10188392B2 (en) 2014-12-19 2019-01-29 Abbott Cardiovascular Systems, Inc. Grasping for tissue repair
US9480565B2 (en) * 2015-02-02 2016-11-01 On-X Life Technologies, Inc. Rapid deployment artificial chordae tendinae system
WO2016125160A1 (en) 2015-02-05 2016-08-11 Mitraltech Ltd. Prosthetic valve with axially-sliding frames
EP4292551A3 (en) 2015-03-05 2024-01-31 Ancora Heart, Inc. Devices of visualizing and determining depth of penetration in cardiac tissue
US20160256269A1 (en) 2015-03-05 2016-09-08 Mitralign, Inc. Devices for treating paravalvular leakage and methods use thereof
WO2016144391A1 (en) 2015-03-11 2016-09-15 Mvrx, Inc. Devices, systems, and methods for reshaping a heart valve annulus
US10524912B2 (en) 2015-04-02 2020-01-07 Abbott Cardiovascular Systems, Inc. Tissue fixation devices and methods
CN111265335B (en) 2015-04-30 2022-03-15 瓦尔泰克卡迪欧有限公司 Valvuloplasty techniques
EP4074285A1 (en) 2015-05-12 2022-10-19 Ancora Heart, Inc. Device for releasing catheters from cardiac structures
US10376673B2 (en) 2015-06-19 2019-08-13 Evalve, Inc. Catheter guiding system and methods
US10238494B2 (en) 2015-06-29 2019-03-26 Evalve, Inc. Self-aligning radiopaque ring
US10667815B2 (en) 2015-07-21 2020-06-02 Evalve, Inc. Tissue grasping devices and related methods
US10413408B2 (en) 2015-08-06 2019-09-17 Evalve, Inc. Delivery catheter systems, methods, and devices
EP3346926B1 (en) 2015-09-10 2020-10-21 Bioventrix, Inc. Systems for deploying a cardiac anchor
WO2017059406A1 (en) 2015-10-01 2017-04-06 Neochord, Inc. Ringless web for repair of heart valves
US10238495B2 (en) 2015-10-09 2019-03-26 Evalve, Inc. Delivery catheter handle and methods of use
US10463492B2 (en) 2015-11-17 2019-11-05 Edwards Lifesciences Corporation Systems and devices for setting an anchor
US10278818B2 (en) 2015-12-10 2019-05-07 Mvrx, Inc. Devices, systems, and methods for reshaping a heart valve annulus
US10751182B2 (en) 2015-12-30 2020-08-25 Edwards Lifesciences Corporation System and method for reshaping right heart
US10828160B2 (en) 2015-12-30 2020-11-10 Edwards Lifesciences Corporation System and method for reducing tricuspid regurgitation
WO2017132516A1 (en) 2016-01-29 2017-08-03 Kevin Van Bladel Percutaneous arterial access to position transmyocardial implant devices and methods
WO2017156259A1 (en) 2016-03-10 2017-09-14 Lc Therapeutics, Inc. Synthetic chord for cardiac valve repair applications
US10702274B2 (en) 2016-05-26 2020-07-07 Edwards Lifesciences Corporation Method and system for closing left atrial appendage
WO2017210434A1 (en) 2016-06-01 2017-12-07 On-X Life Technologies, Inc. Pull-through chordae tendineae system
US10736632B2 (en) 2016-07-06 2020-08-11 Evalve, Inc. Methods and devices for valve clip excision
GB201611910D0 (en) 2016-07-08 2016-08-24 Valtech Cardio Ltd Adjustable annuloplasty device with alternating peaks and troughs
EP3848003A1 (en) 2016-08-10 2021-07-14 Cardiovalve Ltd. Prosthetic valve with concentric frames
US11071564B2 (en) 2016-10-05 2021-07-27 Evalve, Inc. Cardiac valve cutting device
JP7071350B2 (en) 2016-10-27 2022-05-18 コンフォーマル・メディカル・インコーポレイテッド Devices and methods for eliminating the left atrial appendage
US11426172B2 (en) 2016-10-27 2022-08-30 Conformal Medical, Inc. Devices and methods for excluding the left atrial appendage
US10363138B2 (en) 2016-11-09 2019-07-30 Evalve, Inc. Devices for adjusting the curvature of cardiac valve structures
US10398553B2 (en) 2016-11-11 2019-09-03 Evalve, Inc. Opposing disk device for grasping cardiac valve tissue
US10426616B2 (en) 2016-11-17 2019-10-01 Evalve, Inc. Cardiac implant delivery system
AU2017362497B2 (en) 2016-11-18 2022-07-28 Ancora Heart, Inc. Myocardial implant load sharing device and methods to promote LV function
US10779837B2 (en) 2016-12-08 2020-09-22 Evalve, Inc. Adjustable arm device for grasping tissues
US10314586B2 (en) 2016-12-13 2019-06-11 Evalve, Inc. Rotatable device and method for fixing tricuspid valve tissue
US10390953B2 (en) 2017-03-08 2019-08-27 Cardiac Dimensions Pty. Ltd. Methods and devices for reducing paravalvular leakage
US10898330B2 (en) 2017-03-28 2021-01-26 Edwards Lifesciences Corporation Positioning, deploying, and retrieving implantable devices
US10213306B2 (en) 2017-03-31 2019-02-26 Neochord, Inc. Minimally invasive heart valve repair in a beating heart
US11045627B2 (en) 2017-04-18 2021-06-29 Edwards Lifesciences Corporation Catheter system with linear actuation control mechanism
US11065119B2 (en) 2017-05-12 2021-07-20 Evalve, Inc. Long arm valve repair clip
US10835221B2 (en) 2017-11-02 2020-11-17 Valtech Cardio, Ltd. Implant-cinching devices and systems
US11135062B2 (en) 2017-11-20 2021-10-05 Valtech Cardio Ltd. Cinching of dilated heart muscle
WO2019108286A1 (en) * 2017-11-30 2019-06-06 Boston Scientific Scimed, Inc. Connected anchor delivery systems and methods for valve repair
CN111655200B (en) 2018-01-24 2023-07-14 爱德华兹生命科学创新(以色列)有限公司 Contraction of annuloplasty structures
CN110074834A (en) * 2018-01-25 2019-08-02 上海微创医疗器械(集团)有限公司 Medical device
EP4248904A3 (en) 2018-01-26 2023-11-29 Edwards Lifesciences Innovation (Israel) Ltd. Techniques for facilitating heart valve tethering and chord replacement
EP3768176B1 (en) 2018-03-23 2024-03-20 NeoChord, Inc. Device for suture attachment for minimally invasive heart valve repair
WO2019191271A1 (en) 2018-03-28 2019-10-03 Datascope Corp. Device for atrial appendage exclusion
US11173030B2 (en) 2018-05-09 2021-11-16 Neochord, Inc. Suture length adjustment for minimally invasive heart valve repair
US11253360B2 (en) 2018-05-09 2022-02-22 Neochord, Inc. Low profile tissue anchor for minimally invasive heart valve repair
WO2020012481A2 (en) 2018-07-12 2020-01-16 Valtech Cardio, Ltd. Annuloplasty systems and locking tools therefor
US10966709B2 (en) 2018-09-07 2021-04-06 Neochord, Inc. Device for suture attachment for minimally invasive heart valve repair
WO2020163507A1 (en) 2019-02-08 2020-08-13 Conformal Medical, Inc. Devices and methods for excluding the left atrial appendage
WO2020214818A1 (en) 2019-04-16 2020-10-22 Neochord, Inc. Transverse helical cardiac anchor for minimally invasive heart valve repair
CA3147413A1 (en) 2019-07-15 2021-01-21 Ancora Heart, Inc. Devices and methods for tether cutting
US11540838B2 (en) 2019-08-30 2023-01-03 Boston Scientific Scimed, Inc. Left atrial appendage implant with sealing disk
EP4193934A1 (en) 2019-10-29 2023-06-14 Edwards Lifesciences Innovation (Israel) Ltd. Annuloplasty and tissue anchor technologies
EP4125634A1 (en) 2020-03-24 2023-02-08 Boston Scientific Scimed Inc. Medical system for treating a left atrial appendage
EP4259045A1 (en) 2020-12-14 2023-10-18 Cardiac Dimensions Pty. Ltd. Modular pre-loaded medical implants and delivery systems

Family Cites Families (318)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US34021A (en) * 1861-12-24 Ufacture of fibrous water
US575783A (en) * 1897-01-26 X nofmiis peters co
US963899A (en) * 1909-11-06 1910-07-12 Kistler Samuel L Surgical clamp.
GB583012A (en) * 1944-09-21 1946-12-04 E R Watts & Son Ltd Improvements in magnetic compasses
US3019790A (en) * 1960-07-15 1962-02-06 Robert J Militana Combination hemostat and intravenous needle
NL143127B (en) * 1969-02-04 1974-09-16 Rhone Poulenc Sa REINFORCEMENT DEVICE FOR A DEFECTIVE HEART VALVE.
US3868956A (en) * 1972-06-05 1975-03-04 Ralph J Alfidi Vessel implantable appliance and method of implanting it
US3980086A (en) * 1974-02-28 1976-09-14 Bio-Medicus, Inc. Fluid conveying surgical instrument
GB1492964A (en) * 1974-04-02 1977-11-23 Cav Ltd Fuel injection pumping apparatus governor
FR2306671A1 (en) * 1975-04-11 1976-11-05 Rhone Poulenc Ind VALVULAR IMPLANT
FR2298313A1 (en) * 1975-06-23 1976-08-20 Usifroid LINEAR REDUCER FOR VALVULOPLASTY
US4035849A (en) * 1975-11-17 1977-07-19 William W. Angell Heart valve stent and process for preparing a stented heart valve prosthesis
US4048990A (en) * 1976-09-17 1977-09-20 Goetz Robert H Heart massage apparatus
US4192293A (en) * 1978-09-05 1980-03-11 Manfred Asrican Cardiac assist device
ES474582A1 (en) * 1978-10-26 1979-11-01 Aranguren Duo Iker Process for installing mitral valves in their anatomical space by attaching cords to an artificial stent
JPS5563638A (en) * 1978-11-09 1980-05-13 Olympus Optical Co Renal pelvis forceps
US4281659A (en) * 1979-03-12 1981-08-04 Roche Medical Electronics Inc. Applying and securing percutaneous or transcutaneous probes to the skin especially for fetal monitoring
GB2056023B (en) * 1979-08-06 1983-08-10 Ross D N Bodnar E Stent for a cardiac valve
US4306319A (en) * 1980-06-16 1981-12-22 Robert L. Kaster Heart valve with non-circular body
US4372293A (en) * 1980-12-24 1983-02-08 Vijil Rosales Cesar A Apparatus and method for surgical correction of ptotic breasts
US4409974A (en) * 1981-06-29 1983-10-18 Freedland Jeffrey A Bone-fixating surgical implant device
IT1155105B (en) * 1982-03-03 1987-01-21 Roberto Parravicini PLANT DEVICE TO SUPPORT THE MYOCARDIUM ACTIVITY
DE3227984C2 (en) 1982-07-27 1985-10-17 Abdoll-Hossein Dr. med. 4330 Mülheim Towfigh Device for producing a tendon butt seam
US4579120A (en) * 1982-09-30 1986-04-01 Cordis Corporation Strain relief for percutaneous lead
US4592342A (en) * 1983-05-02 1986-06-03 Salmasian Samuel S Method for appetite suppression and weight loss maintenance and device
US4629459A (en) * 1983-12-28 1986-12-16 Shiley Inc. Alternate stent covering for tissue valves
US4632101A (en) * 1985-01-31 1986-12-30 Yosef Freedland Orthopedic fastener
US5104392A (en) * 1985-03-22 1992-04-14 Massachusetts Institute Of Technology Laser spectro-optic imaging for diagnosis and treatment of diseased tissue
US4690134A (en) 1985-07-01 1987-09-01 Snyders Robert V Ventricular assist device
US4705040A (en) 1985-11-18 1987-11-10 Medi-Tech, Incorporated Percutaneous fixation of hollow organs
USRE34021E (en) 1985-11-18 1992-08-04 Abbott Laboratories Percutaneous fixation of hollow organs
DE3614292C1 (en) * 1986-04-26 1987-11-19 Alexander Prof Dr Bernhard Holder for unframed biological mitral valve implant
CA1303298C (en) * 1986-08-06 1992-06-16 Alain Carpentier Flexible cardiac valvular support prosthesis
SU1604377A1 (en) * 1987-02-23 1990-11-07 Благовещенский государственный медицинский институт Artificial pericardium
US4925443A (en) * 1987-02-27 1990-05-15 Heilman Marlin S Biocompatible ventricular assist and arrhythmia control device
GB2214428B (en) 1988-01-09 1991-06-26 Ali Waqar Majeed Surgical device
US5156621A (en) * 1988-03-22 1992-10-20 Navia Jose A Stentless bioprosthetic cardiac valve
US4960424A (en) * 1988-06-30 1990-10-02 Grooters Ronald K Method of replacing a defective atrio-ventricular valve with a total atrio-ventricular valve bioprosthesis
US4990424A (en) * 1988-08-12 1991-02-05 Xerox Corporation Toner and developer compositions with semicrystalline polyolefin resin blends
US4944753A (en) * 1988-09-26 1990-07-31 Burgess Frank M Method for producing retro-sternal space
EP0595791B1 (en) 1989-02-13 1999-06-30 Baxter International Inc. Anuloplasty ring prosthesis
US4991578A (en) 1989-04-04 1991-02-12 Siemens-Pacesetter, Inc. Method and system for implanting self-anchoring epicardial defibrillation electrodes
US5484885A (en) 1989-07-05 1996-01-16 Emory University Chemotactic, antibiotic and lipopolysaccharide-binding peptide fragments of CAP37
US5290300A (en) 1989-07-31 1994-03-01 Baxter International Inc. Flexible suture guide and holder
US4997431A (en) * 1989-08-30 1991-03-05 Angeion Corporation Catheter
US5129906A (en) 1989-09-08 1992-07-14 Linvatec Corporation Bioabsorbable tack for joining bodily tissue and in vivo method and apparatus for deploying same
US5131905A (en) * 1990-07-16 1992-07-21 Grooters Ronald K External cardiac assist device
US5389096A (en) * 1990-12-18 1995-02-14 Advanced Cardiovascular Systems System and method for percutaneous myocardial revascularization
US5245102A (en) 1990-11-29 1993-09-14 Uop Isomerization with distillation and psa recycle streams
CA2059245C (en) * 1991-02-08 2004-07-06 Michael P. Chesterfield Method and apparatus for calendering and coating/filling sutures
JPH05184611A (en) * 1991-03-19 1993-07-27 Kenji Kusuhara Valvular annulation retaining member and its attaching method
US5300087A (en) * 1991-03-22 1994-04-05 Knoepfler Dennis J Multiple purpose forceps
US5169381A (en) * 1991-03-29 1992-12-08 Snyders Robert V Ventricular assist device
US5258015A (en) * 1991-05-03 1993-11-02 American Cyanamid Company Locking filament caps
US5452733A (en) * 1993-02-22 1995-09-26 Stanford Surgical Technologies, Inc. Methods for performing thoracoscopic coronary artery bypass
US5458574A (en) * 1994-03-16 1995-10-17 Heartport, Inc. System for performing a cardiac procedure
US5584803A (en) * 1991-07-16 1996-12-17 Heartport, Inc. System for cardiac procedures
US5571215A (en) * 1993-02-22 1996-11-05 Heartport, Inc. Devices and methods for intracardiac procedures
US5344385A (en) * 1991-09-30 1994-09-06 Thoratec Laboratories Corporation Step-down skeletal muscle energy conversion system
DK168419B1 (en) * 1991-11-25 1994-03-28 Cook Inc A Cook Group Company Abdominal wall support device and apparatus for insertion thereof
US5192314A (en) * 1991-12-12 1993-03-09 Daskalakis Michael K Synthetic intraventricular implants and method of inserting
US5250049A (en) * 1992-01-10 1993-10-05 Michael Roger H Bone and tissue connectors
DE69331315T2 (en) * 1992-01-27 2002-08-22 Medtronic Inc ANULOPLASTIC AND SEAM RINGS
US5258021A (en) * 1992-01-27 1993-11-02 Duran Carlos G Sigmoid valve annuloplasty ring
US5758663A (en) 1992-04-10 1998-06-02 Wilk; Peter J. Coronary artery by-pass method
US5332402A (en) * 1992-05-12 1994-07-26 Teitelbaum George P Percutaneously-inserted cardiac valve
NL9200878A (en) 1992-05-19 1993-12-16 Dirk Wouter Meijer En Joannes Medical-instrument-insertion equipment in body cavity - has devices detachably securing tube distal end to wall of hollow organ
US5383840A (en) * 1992-07-28 1995-01-24 Vascor, Inc. Biocompatible ventricular assist and arrhythmia control device including cardiac compression band-stay-pad assembly
US5256132A (en) * 1992-08-17 1993-10-26 Snyders Robert V Cardiac assist envelope for endoscopic application
DE4234127C2 (en) * 1992-10-09 1996-02-22 Herbert Dr Vetter Heart valve prosthesis
US5814097A (en) * 1992-12-03 1998-09-29 Heartport, Inc. Devices and methods for intracardiac procedures
US5718725A (en) * 1992-12-03 1998-02-17 Heartport, Inc. Devices and methods for intracardiac procedures
US5284488A (en) * 1992-12-23 1994-02-08 Sideris Eleftherios B Adjustable devices for the occlusion of cardiac defects
US5522884A (en) * 1993-02-19 1996-06-04 Medtronic, Inc. Holder for adjustable mitral & tricuspid annuloplasty rings
US6010531A (en) * 1993-02-22 2000-01-04 Heartport, Inc. Less-invasive devices and methods for cardiac valve surgery
US5797960A (en) * 1993-02-22 1998-08-25 Stevens; John H. Method and apparatus for thoracoscopic intracardiac procedures
US5972030A (en) 1993-02-22 1999-10-26 Heartport, Inc. Less-invasive devices and methods for treatment of cardiac valves
US20020029783A1 (en) * 1993-02-22 2002-03-14 Stevens John H. Minimally-invasive devices and methods for treatment of congestive heart failure
US6125852A (en) 1993-02-22 2000-10-03 Heartport, Inc. Minimally-invasive devices and methods for treatment of congestive heart failure
US5728151A (en) * 1993-02-22 1998-03-17 Heartport, Inc. Intercostal access devices for less-invasive cardiovascular surgery
DE4306277C2 (en) 1993-03-01 2000-11-02 Leibinger Gmbh Operation marking tool
DE4317752C2 (en) * 1993-05-27 1997-10-16 Peter Dr Feindt Device for supporting cardiac function
US6258021B1 (en) 1993-06-17 2001-07-10 Peter J. Wilk Intrapericardial assist method
US5800334A (en) * 1993-06-17 1998-09-01 Wilk; Peter J. Intrapericardial assist device and associated method
US5385528A (en) * 1993-06-17 1995-01-31 Wilk; Peter J. Intrapericardial assist device and associated method
US5533958A (en) * 1993-06-17 1996-07-09 Wilk; Peter J. Intrapericardial assist device and associated method
US5971911A (en) 1993-06-17 1999-10-26 Wilk; Peter J. Intrapericardial assist device and associated method
US6572529B2 (en) * 1993-06-17 2003-06-03 Wilk Patent Development Corporation Intrapericardial assist method
US6776754B1 (en) 2000-10-04 2004-08-17 Wilk Patent Development Corporation Method for closing off lower portion of heart ventricle
US6155968A (en) 1998-07-23 2000-12-05 Wilk; Peter J. Method and device for improving cardiac function
FR2708458B1 (en) * 1993-08-03 1995-09-15 Seguin Jacques Prosthetic ring for cardiac surgery.
US5450860A (en) * 1993-08-31 1995-09-19 W. L. Gore & Associates, Inc. Device for tissue repair and method for employing same
CA2181045C (en) * 1993-12-17 2004-08-31 John H. Stevens System for cardiac procedures
US5417709A (en) * 1994-04-12 1995-05-23 Symbiosis Corporation Endoscopic instrument with end effectors forming suction and/or irrigation lumens
US5445600A (en) * 1994-04-29 1995-08-29 Abdulla; Ra-Id Flow control systemic to pulmonary arterial shunt
US5509428A (en) * 1994-05-31 1996-04-23 Dunlop; Richard W. Method and apparatus for the creation of tricuspid regurgitation
US6217610B1 (en) * 1994-07-29 2001-04-17 Edwards Lifesciences Corporation Expandable annuloplasty ring
US5593435A (en) * 1994-07-29 1997-01-14 Baxter International Inc. Distensible annuloplasty ring for surgical remodelling of an atrioventricular valve and nonsurgical method for post-implantation distension thereof to accommodate patient growth
US5593424A (en) * 1994-08-10 1997-01-14 Segmed, Inc. Apparatus and method for reducing and stabilizing the circumference of a vascular structure
US5433727A (en) * 1994-08-16 1995-07-18 Sideris; Eleftherios B. Centering buttoned device for the occlusion of large defects for occluding
US5749839A (en) * 1994-08-18 1998-05-12 Duke University Direct mechanical bi-ventricular cardiac assist device
DE29500381U1 (en) 1994-08-24 1995-07-20 Schneidt Bernhard Ing Grad Device for closing a duct, in particular the ductus arteriosus
JPH08196538A (en) 1994-09-26 1996-08-06 Ethicon Inc Tissue sticking apparatus for surgery with elastomer component and method of attaching mesh for surgery to said tissue
IL115680A (en) * 1994-10-21 1999-03-12 St Jude Medical Rotatable cuff assembly for a heart valve prosthesis
US5849005A (en) * 1995-06-07 1998-12-15 Heartport, Inc. Method and apparatus for minimizing the risk of air embolism when performing a procedure in a patient's thoracic cavity
US5840059A (en) * 1995-06-07 1998-11-24 Cardiogenesis Corporation Therapeutic and diagnostic agent delivery
US6132438A (en) * 1995-06-07 2000-10-17 Ep Technologies, Inc. Devices for installing stasis reducing means in body tissue
US5713954A (en) * 1995-06-13 1998-02-03 Abiomed R&D, Inc. Extra cardiac ventricular assist device
US5800528A (en) * 1995-06-13 1998-09-01 Abiomed R & D, Inc. Passive girdle for heart ventricle for therapeutic aid to patients having ventricular dilatation
US5716399A (en) * 1995-10-06 1998-02-10 Cardiomend Llc Methods of heart valve repair
DE19538796C2 (en) 1995-10-18 1999-09-23 Fraunhofer Ges Forschung Device for supporting the heart function with elastic filling chambers
AU720907B2 (en) * 1995-12-01 2000-06-15 Medtronic, Inc. Annuloplasty prosthesis
US6520904B1 (en) * 1996-01-02 2003-02-18 The University Of Cincinnati Device and method for restructuring heart chamber geometry
US6592619B2 (en) * 1996-01-02 2003-07-15 University Of Cincinnati Heart wall actuation device for the natural heart
US5957977A (en) 1996-01-02 1999-09-28 University Of Cincinnati Activation device for the natural heart including internal and external support structures
US6182664B1 (en) 1996-02-19 2001-02-06 Edwards Lifesciences Corporation Minimally invasive cardiac valve surgery procedure
EP0792621A1 (en) 1996-02-29 1997-09-03 Munir Dr. Uwaydah Cannulated clamp
US6814700B1 (en) * 1996-03-04 2004-11-09 Heartport, Inc. Soft tissue retractor and method for providing surgical access
US5800478A (en) * 1996-03-07 1998-09-01 Light Sciences Limited Partnership Flexible microcircuits for internal light therapy
US5853422A (en) * 1996-03-22 1998-12-29 Scimed Life Systems, Inc. Apparatus and method for closing a septal defect
US5738649A (en) * 1996-04-16 1998-04-14 Cardeon Corporation Peripheral entry biventricular catheter system for providing access to the heart for cardiopulmonary surgery or for prolonged circulatory support of the heart
US6488706B1 (en) 1996-05-08 2002-12-03 Carag Ag Device for plugging an opening such as in a wall of a hollow or tubular organ
US5855601A (en) 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
US5972019A (en) 1996-07-25 1999-10-26 Target Therapeutics, Inc. Mechanical clot treatment device
US5755783A (en) 1996-07-29 1998-05-26 Stobie; Robert Suture rings for rotatable artificial heart valves
EP0930857B1 (en) * 1996-09-13 2003-05-02 Medtronic, Inc. Prosthetic heart valve with suturing member having non-uniform radial width
US5655548A (en) * 1996-09-16 1997-08-12 Circulation, Inc. Method for treatment of ischemic heart disease by providing transvenous myocardial perfusion
US5800531A (en) 1996-09-30 1998-09-01 Baxter International Inc. Bioprosthetic heart valve implantation device
US6123662A (en) 1998-07-13 2000-09-26 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
US5702343A (en) 1996-10-02 1997-12-30 Acorn Medical, Inc. Cardiac reinforcement device
WO1998017347A1 (en) 1996-10-18 1998-04-30 Cardio Technologies, Inc. Method and apparatus for assisting a heart
US5827268A (en) * 1996-10-30 1998-10-27 Hearten Medical, Inc. Device for the treatment of patent ductus arteriosus and method of using the device
EP0839497A1 (en) 1996-11-01 1998-05-06 EndoSonics Corporation A method for measuring volumetric fluid flow and its velocity profile in a lumen or other body cavity
DE29619294U1 (en) * 1996-11-07 1997-07-17 Caic Pero Heart cuff
US5865749A (en) * 1996-11-07 1999-02-02 Data Sciences International, Inc. Blood flow meter apparatus and method of use
US6120520A (en) 1997-05-27 2000-09-19 Angiotrax, Inc. Apparatus and methods for stimulating revascularization and/or tissue growth
US6206004B1 (en) * 1996-12-06 2001-03-27 Comedicus Incorporated Treatment method via the pericardial space
US6071303A (en) 1996-12-08 2000-06-06 Hearten Medical, Inc. Device for the treatment of infarcted tissue and method of treating infarcted tissue
US5807384A (en) * 1996-12-20 1998-09-15 Eclipse Surgical Technologies, Inc. Transmyocardial revascularization (TMR) enhanced treatment for coronary artery disease
US5999678A (en) * 1996-12-27 1999-12-07 Eclipse Surgical Technologies, Inc. Laser delivery means adapted for drug delivery
US7883539B2 (en) 1997-01-02 2011-02-08 Edwards Lifesciences Llc Heart wall tension reduction apparatus and method
US6050936A (en) * 1997-01-02 2000-04-18 Myocor, Inc. Heart wall tension reduction apparatus
US6406420B1 (en) * 1997-01-02 2002-06-18 Myocor, Inc. Methods and devices for improving cardiac function in hearts
US6045497A (en) 1997-01-02 2000-04-04 Myocor, Inc. Heart wall tension reduction apparatus and method
US6183411B1 (en) 1998-09-21 2001-02-06 Myocor, Inc. External stress reduction device and method
US5961440A (en) * 1997-01-02 1999-10-05 Myocor, Inc. Heart wall tension reduction apparatus and method
US20030045771A1 (en) 1997-01-02 2003-03-06 Schweich Cyril J. Heart wall tension reduction devices and methods
US6077214A (en) 1998-07-29 2000-06-20 Myocor, Inc. Stress reduction apparatus and method
US5961539A (en) 1997-01-17 1999-10-05 Segmed, Inc. Method and apparatus for sizing, stabilizing and/or reducing the circumference of an anatomical structure
US5928224A (en) * 1997-01-24 1999-07-27 Hearten Medical, Inc. Device for the treatment of damaged heart valve leaflets and methods of using the device
US5776189A (en) 1997-03-05 1998-07-07 Khalid; Naqeeb Cardiac valvular support prosthesis
US6443949B2 (en) 1997-03-13 2002-09-03 Biocardia, Inc. Method of drug delivery to interstitial regions of the myocardium
US5928281A (en) 1997-03-27 1999-07-27 Baxter International Inc. Tissue heart valves
US5961549A (en) 1997-04-03 1999-10-05 Baxter International Inc. Multi-leaflet bioprosthetic heart valve
US6090096A (en) * 1997-04-23 2000-07-18 Heartport, Inc. Antegrade cardioplegia catheter and method
US6432059B2 (en) 1997-06-12 2002-08-13 The Research Foundation Of State University Of New York Method and apparatus for more precisely determined mean left atrial pressure
JP2002504841A (en) 1997-06-21 2002-02-12 ハインドル・ハンス A bag surrounding at least part of the heart
DE29824017U1 (en) 1997-06-21 2000-05-25 Haindl Hans Pouch for at least partially enclosing a heart
WO1999000059A1 (en) 1997-06-27 1999-01-07 The Trustees Of Columbia University In The City Of New York Method and apparatus for circulatory valve repair
US20030105519A1 (en) 1997-09-04 2003-06-05 Roland Fasol Artificial chordae replacement
FR2768324B1 (en) * 1997-09-12 1999-12-10 Jacques Seguin SURGICAL INSTRUMENT FOR PERCUTANEOUSLY FIXING TWO AREAS OF SOFT TISSUE, NORMALLY MUTUALLY REMOTE, TO ONE ANOTHER
US6019722A (en) 1997-09-17 2000-02-01 Guidant Corporation Device to permit offpump beating heart coronary bypass surgery
US6338712B2 (en) 1997-09-17 2002-01-15 Origin Medsystems, Inc. Device to permit offpump beating heart coronary bypass surgery
US6361545B1 (en) 1997-09-26 2002-03-26 Cardeon Corporation Perfusion filter catheter
US6086532A (en) 1997-09-26 2000-07-11 Ep Technologies, Inc. Systems for recording use of structures deployed in association with heart tissue
CA2308426A1 (en) 1997-11-03 1999-05-14 William A. Easterbrook, Iii Method and apparatus for assisting a heart to pump blood
US6113636A (en) 1997-11-20 2000-09-05 St. Jude Medical, Inc. Medical article with adhered antimicrobial metal
US6332893B1 (en) * 1997-12-17 2001-12-25 Myocor, Inc. Valve to myocardium tension members device and method
US6001126A (en) 1997-12-24 1999-12-14 Baxter International Inc. Stentless bioprosthetic heart valve with coronary protuberances and related methods for surgical repair of defective heart valves
ES2293473T3 (en) 1998-02-05 2008-03-16 Biosense Webster, Inc. INTRACARDIAC ADMINISTRATION OF FARMACO.
US5944738A (en) 1998-02-06 1999-08-31 Aga Medical Corporation Percutaneous catheter directed constricting occlusion device
US6314322B1 (en) 1998-03-02 2001-11-06 Abiomed, Inc. System and method for treating dilated cardiomyopathy using end diastolic volume (EDV) sensing
US6190408B1 (en) 1998-03-05 2001-02-20 The University Of Cincinnati Device and method for restructuring the heart chamber geometry
US5902229A (en) 1998-03-30 1999-05-11 Cardio Technologies, Inc. Drive system for controlling cardiac compression
US6095968A (en) 1998-04-10 2000-08-01 Cardio Technologies, Inc. Reinforcement device
US6110100A (en) 1998-04-22 2000-08-29 Scimed Life Systems, Inc. System for stress relieving the heart muscle and for controlling heart function
US6544167B2 (en) 1998-05-01 2003-04-08 Correstore, Inc. Ventricular restoration patch
US6024096A (en) 1998-05-01 2000-02-15 Correstore Inc Anterior segment ventricular restoration apparatus and method
US6221104B1 (en) 1998-05-01 2001-04-24 Cor Restore, Inc. Anterior and interior segment cardiac restoration apparatus and method
US6511426B1 (en) 1998-06-02 2003-01-28 Acuson Corporation Medical diagnostic ultrasound system and method for versatile processing
US6250308B1 (en) 1998-06-16 2001-06-26 Cardiac Concepts, Inc. Mitral valve annuloplasty ring and method of implanting
US6085754A (en) 1998-07-13 2000-07-11 Acorn Cardiovascular, Inc. Cardiac disease treatment method
US6165183A (en) 1998-07-15 2000-12-26 St. Jude Medical, Inc. Mitral and tricuspid valve repair
US6547821B1 (en) 1998-07-16 2003-04-15 Cardiothoracic Systems, Inc. Surgical procedures and devices for increasing cardiac output of the heart
US6260552B1 (en) 1998-07-29 2001-07-17 Myocor, Inc. Transventricular implant tools and devices
US5967990A (en) 1998-08-13 1999-10-19 President And Fellows Of Harvard College Surgical probe comprising visible markings on an elastic membrane
US6251061B1 (en) 1998-09-09 2001-06-26 Scimed Life Systems, Inc. Cardiac assist device using field controlled fluid
US6113536A (en) 1998-09-30 2000-09-05 A-Med Systems, Inc. Device and method of attaching a blood pump and tubes to a surgical retractor
DE19947885B4 (en) 1998-10-05 2009-04-09 Cardiothoracic Systems, Inc., Cupertino Device for positioning the heart during cardiac surgery while maintaining cardiac output
US6685627B2 (en) 1998-10-09 2004-02-03 Swaminathan Jayaraman Modification of properties and geometry of heart tissue to influence heart function
US6360749B1 (en) 1998-10-09 2002-03-26 Swaminathan Jayaraman Modification of properties and geometry of heart tissue to influence heart function
US6587734B2 (en) 1998-11-04 2003-07-01 Acorn Cardiovascular, Inc. Cardio therapeutic heart sack
US6169922B1 (en) 1998-11-18 2001-01-02 Acorn Cardiovascular, Inc. Defibrillating cardiac jacket with interwoven electrode grids
US6230714B1 (en) 1998-11-18 2001-05-15 Acorn Cardiovascular, Inc. Cardiac constraint with prior venus occlusion methods
US6432039B1 (en) 1998-12-21 2002-08-13 Corset, Inc. Methods and apparatus for reinforcement of the heart ventricles
US6155972A (en) 1999-02-02 2000-12-05 Acorn Cardiovascular, Inc. Cardiac constraint jacket construction
US6701929B2 (en) 1999-03-03 2004-03-09 Hany Hussein Device and method for treatment of congestive heart failure
US6695768B1 (en) 1999-03-30 2004-02-24 Robert A. Levine Adjustable periventricular ring/ring like device/method for control of ischemic mitral regurgitation and congestive heart disease
US7563267B2 (en) 1999-04-09 2009-07-21 Evalve, Inc. Fixation device and methods for engaging tissue
AU770243B2 (en) 1999-04-09 2004-02-19 Evalve, Inc. Methods and apparatus for cardiac valve repair
US6752813B2 (en) 1999-04-09 2004-06-22 Evalve, Inc. Methods and devices for capturing and fixing leaflets in valve repair
US6331157B2 (en) 1999-04-15 2001-12-18 Heartport, Inc. Apparatus and methods for off-pump cardiac surgery
US6994669B1 (en) 1999-04-15 2006-02-07 Heartport, Inc. Apparatus and method for cardiac surgery
US6183512B1 (en) 1999-04-16 2001-02-06 Edwards Lifesciences Corporation Flexible annuloplasty system
US6577902B1 (en) 1999-04-16 2003-06-10 Tony R. Brown Device for shaping infarcted heart tissue and method of using the device
US6231602B1 (en) 1999-04-16 2001-05-15 Edwards Lifesciences Corporation Aortic annuloplasty ring
US6260820B1 (en) 1999-05-21 2001-07-17 Nordstrom Valves, Inc. Valve with rotatable valve member and method for forming same
SE514718C2 (en) 1999-06-29 2001-04-09 Jan Otto Solem Apparatus for treating defective closure of the mitral valve apparatus
US7192442B2 (en) 1999-06-30 2007-03-20 Edwards Lifesciences Ag Method and device for treatment of mitral insufficiency
US6997951B2 (en) 1999-06-30 2006-02-14 Edwards Lifesciences Ag Method and device for treatment of mitral insufficiency
US6241654B1 (en) 1999-07-07 2001-06-05 Acorn Cardiovasculr, Inc. Cardiac reinforcement devices and methods
US6258023B1 (en) 1999-07-08 2001-07-10 Chase Medical, Inc. Device and method for isolating a surface of a beating heart during surgery
US7264587B2 (en) 1999-08-10 2007-09-04 Origin Medsystems, Inc. Endoscopic subxiphoid surgical procedures
US6231561B1 (en) 1999-09-20 2001-05-15 Appriva Medical, Inc. Method and apparatus for closing a body lumen
US6179791B1 (en) 1999-09-21 2001-01-30 Acorn Cardiovascular, Inc. Device for heart measurement
US6174279B1 (en) 1999-09-21 2001-01-16 Acorn Cardiovascular, Inc. Cardiac constraint with tension indicator
US6193648B1 (en) 1999-09-21 2001-02-27 Acorn Cardiovascular, Inc. Cardiac constraint with draw string tensioning
US6312447B1 (en) 1999-10-13 2001-11-06 The General Hospital Corporation Devices and methods for percutaneous mitral valve repair
US6626930B1 (en) 1999-10-21 2003-09-30 Edwards Lifesciences Corporation Minimally invasive mitral valve repair method and apparatus
US20010041914A1 (en) 1999-11-22 2001-11-15 Frazier Andrew G.C. Tissue patch deployment catheter
US6702732B1 (en) 1999-12-22 2004-03-09 Paracor Surgical, Inc. Expandable cardiac harness for treating congestive heart failure
US6409759B1 (en) 1999-12-30 2002-06-25 St. Jude Medical, Inc. Harvested tissue heart valve with sewing rim
US6293906B1 (en) 2000-01-14 2001-09-25 Acorn Cardiovascular, Inc. Delivery of cardiac constraint jacket
US6769434B2 (en) 2000-06-30 2004-08-03 Viacor, Inc. Method and apparatus for performing a procedure on a cardiac valve
US6989028B2 (en) 2000-01-31 2006-01-24 Edwards Lifesciences Ag Medical system and method for remodeling an extravascular tissue structure
US6402781B1 (en) 2000-01-31 2002-06-11 Mitralife Percutaneous mitral annuloplasty and cardiac reinforcement
US7296577B2 (en) 2000-01-31 2007-11-20 Edwards Lifescience Ag Transluminal mitral annuloplasty with active anchoring
US6406422B1 (en) 2000-03-02 2002-06-18 Levram Medical Devices, Ltd. Ventricular-assist method and apparatus
EP1261294B1 (en) 2000-03-10 2006-11-29 Paracor Medical, Inc. Expandable cardiac harness for treating congestive heart failure
US6537198B1 (en) 2000-03-21 2003-03-25 Myocor, Inc. Splint assembly for improving cardiac function in hearts, and method for implanting the splint assembly
US6454799B1 (en) 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
ITPC20000013A1 (en) 2000-04-13 2000-07-13 Paolo Ferrazzi INTROVENTRICULAR DEVICE AND RELATED METHOD FOR THE TREATMENT AND CORRECTION OF MYOCARDIOPATHIES.
US7083628B2 (en) 2002-09-03 2006-08-01 Edwards Lifesciences Corporation Single catheter mitral valve repair device and method for use
US6425856B1 (en) 2000-05-10 2002-07-30 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
US20030023132A1 (en) 2000-05-31 2003-01-30 Melvin David B. Cyclic device for restructuring heart chamber geometry
US6730016B1 (en) 2000-06-12 2004-05-04 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
US6482146B1 (en) 2000-06-13 2002-11-19 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
US6951534B2 (en) 2000-06-13 2005-10-04 Acorn Cardiovascular, Inc. Cardiac support device
US6702826B2 (en) 2000-06-23 2004-03-09 Viacor, Inc. Automated annular plication for mitral valve repair
US6343605B1 (en) 2000-08-08 2002-02-05 Scimed Life Systems, Inc. Percutaneous transluminal myocardial implantation device and method
SE0002878D0 (en) 2000-08-11 2000-08-11 Kimblad Ola Device and method of treatment of atrioventricular regurgitation
US6572533B1 (en) 2000-08-17 2003-06-03 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
WO2004030570A2 (en) 2002-10-01 2004-04-15 Ample Medical, Inc. Devices for retaining native heart valve leaflet
US6723038B1 (en) 2000-10-06 2004-04-20 Myocor, Inc. Methods and devices for improving mitral valve function
US6616684B1 (en) 2000-10-06 2003-09-09 Myocor, Inc. Endovascular splinting devices and methods
US6673009B1 (en) 2000-11-08 2004-01-06 Acorn Cardiovascular, Inc. Adjustment clamp
US6602182B1 (en) 2000-11-28 2003-08-05 Abiomed, Inc. Cardiac assistance systems having multiple fluid plenums
US6616596B1 (en) 2000-11-28 2003-09-09 Abiomed, Inc. Cardiac assistance systems having multiple layers of inflatable elements
US6755779B2 (en) 2000-12-01 2004-06-29 Acorn Cardiovascular, Inc. Apparatus and method for delivery of cardiac constraint jacket
US6564094B2 (en) 2000-12-22 2003-05-13 Acorn Cardiovascular, Inc. Cardiac disease treatment and device
US7591826B2 (en) 2000-12-28 2009-09-22 Cardiac Dimensions, Inc. Device implantable in the coronary sinus to provide mitral valve therapy
US6786898B2 (en) 2003-01-15 2004-09-07 Medtronic, Inc. Methods and tools for accessing an anatomic space
US6810882B2 (en) 2001-01-30 2004-11-02 Ev3 Santa Rosa, Inc. Transluminal mitral annuloplasty
CA2437824C (en) 2001-02-05 2008-09-23 Viacor, Inc. Apparatus and method for reducing mitral regurgitation
AU2002240288B2 (en) 2001-02-05 2006-05-18 Viacor, Inc. Method and apparatus for improving mitral valve function
US6575921B2 (en) 2001-02-09 2003-06-10 Acorn Cardiovascular, Inc. Device for heart measurement
US6702763B2 (en) 2001-02-28 2004-03-09 Chase Medical, L.P. Sizing apparatus and method for use during ventricular restoration
AU2002327224A1 (en) 2001-03-05 2002-12-09 Viacor, Incorporated Apparatus and method for reducing mitral regurgitation
US6733525B2 (en) 2001-03-23 2004-05-11 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of use
CA2441886C (en) 2001-03-23 2009-07-21 Viacor, Incorporated Method and apparatus for reducing mitral regurgitation
US7186264B2 (en) 2001-03-29 2007-03-06 Viacor, Inc. Method and apparatus for improving mitral valve function
US6619291B2 (en) 2001-04-24 2003-09-16 Edwin J. Hlavka Method and apparatus for catheter-based annuloplasty
US20020188170A1 (en) 2001-04-27 2002-12-12 Santamore William P. Prevention of myocardial infarction induced ventricular expansion and remodeling
US7311731B2 (en) 2001-04-27 2007-12-25 Richard C. Satterfield Prevention of myocardial infarction induced ventricular expansion and remodeling
US7526112B2 (en) 2001-04-30 2009-04-28 Chase Medical, L.P. System and method for facilitating cardiac intervention
US7327862B2 (en) 2001-04-30 2008-02-05 Chase Medical, L.P. System and method for facilitating cardiac intervention
US6800090B2 (en) 2001-05-14 2004-10-05 Cardiac Dimensions, Inc. Mitral valve therapy device, system and method
US6676702B2 (en) 2001-05-14 2004-01-13 Cardiac Dimensions, Inc. Mitral valve therapy assembly and method
ITMI20011012A1 (en) 2001-05-17 2002-11-17 Ottavio Alfieri ANNULAR PROSTHESIS FOR MITRAL VALVE
US6626821B1 (en) 2001-05-22 2003-09-30 Abiomed, Inc. Flow-balanced cardiac wrap
US20040064014A1 (en) 2001-05-31 2004-04-01 Melvin David B. Devices and methods for assisting natural heart function
WO2002102237A2 (en) 2001-06-15 2002-12-27 The Cleveland Clinic Foundation Tissue engineered mitral valve chrodae and methods of making and using same
US6726716B2 (en) 2001-08-24 2004-04-27 Edwards Lifesciences Corporation Self-molding annuloplasty ring
WO2003022131A2 (en) 2001-09-07 2003-03-20 Mardil, Inc. Method and apparatus for external heart stabilization
WO2003022176A2 (en) 2001-09-10 2003-03-20 Paracor Medical, Inc. Cardiac harness
US6685620B2 (en) 2001-09-25 2004-02-03 The Foundry Inc. Ventricular infarct assist device and methods for using it
US7144363B2 (en) 2001-10-16 2006-12-05 Extensia Medical, Inc. Systems for heart treatment
US7052487B2 (en) 2001-10-26 2006-05-30 Cohn William E Method and apparatus for reducing mitral regurgitation
US7311729B2 (en) 2002-01-30 2007-12-25 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US6824562B2 (en) 2002-05-08 2004-11-30 Cardiac Dimensions, Inc. Body lumen device anchor, device and assembly
US6908478B2 (en) 2001-12-05 2005-06-21 Cardiac Dimensions, Inc. Anchor and pull mitral valve device and method
US7179282B2 (en) 2001-12-05 2007-02-20 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US6976995B2 (en) 2002-01-30 2005-12-20 Cardiac Dimensions, Inc. Fixed length anchor and pull mitral valve device and method
US6793673B2 (en) 2002-12-26 2004-09-21 Cardiac Dimensions, Inc. System and method to effect mitral valve annulus of a heart
US6740107B2 (en) 2001-12-19 2004-05-25 Trimedyne, Inc. Device for treatment of atrioventricular valve regurgitation
US20030120340A1 (en) 2001-12-26 2003-06-26 Jan Liska Mitral and tricuspid valve repair
US6764510B2 (en) 2002-01-09 2004-07-20 Myocor, Inc. Devices and methods for heart valve treatment
US6960229B2 (en) 2002-01-30 2005-11-01 Cardiac Dimensions, Inc. Device and method for modifying the shape of a body organ
US7125420B2 (en) 2002-02-05 2006-10-24 Viacor, Inc. Method and apparatus for improving mitral valve function
US7004958B2 (en) 2002-03-06 2006-02-28 Cardiac Dimensions, Inc. Transvenous staples, assembly and method for mitral valve repair
US6797001B2 (en) 2002-03-11 2004-09-28 Cardiac Dimensions, Inc. Device, assembly and method for mitral valve repair
US20030229260A1 (en) 2002-06-05 2003-12-11 Acorn Cardiovascular, Inc. Cardiac support device with tension indicator
US20030229261A1 (en) 2002-06-06 2003-12-11 Acorn Cardiovascular, Inc. Cardiac support devices and methods of producing same
US6682475B2 (en) 2002-06-11 2004-01-27 Acorn Cardiovascular, Inc. Tension indicator for cardiac support device and method therefore
US20030233022A1 (en) 2002-06-12 2003-12-18 Vidlund Robert M. Devices and methods for heart valve treatment
US8287555B2 (en) 2003-02-06 2012-10-16 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
AU2003245507A1 (en) 2002-06-13 2003-12-31 Guided Delivery Systems, Inc. Devices and methods for heart valve repair
US7081084B2 (en) 2002-07-16 2006-07-25 University Of Cincinnati Modular power system and method for a heart wall actuation system for the natural heart
US20040015041A1 (en) 2002-07-18 2004-01-22 The University Of Cincinnati Protective sheath apparatus and method for use with a heart wall actuation system for the natural heart
US20040059180A1 (en) 2002-09-23 2004-03-25 The University Of Cincinnati Basal mounting cushion frame component to facilitate extrinsic heart wall actuation
US20040015040A1 (en) 2002-07-18 2004-01-22 The University Of Cincinnati Flexible, torsionable cardiac framework for heart wall actuation of the natural heart
US8172856B2 (en) 2002-08-02 2012-05-08 Cedars-Sinai Medical Center Methods and apparatus for atrioventricular valve repair
EP1534146B1 (en) 2002-08-13 2008-01-23 The General Hospital Corporation Cardiac devices for percutaneous repair of atrioventricular valves
US6988982B2 (en) 2002-08-19 2006-01-24 Cardioenergetics Heart wall actuation system for the natural heart with shape limiting elements
EP1562522B1 (en) 2002-10-01 2008-12-31 Ample Medical, Inc. Devices and systems for reshaping a heart valve annulus
US7591847B2 (en) 2002-10-10 2009-09-22 The Cleveland Clinic Foundation Stentless bioprosthetic valve having chordae for replacing a mitral valve
US20040133062A1 (en) 2002-10-11 2004-07-08 Suresh Pai Minimally invasive cardiac force transfer structures
BR0315392A (en) 2002-10-21 2005-08-23 Mitralign Inc Incrementing catheters and methods of performing annuloplasty
US7112219B2 (en) 2002-11-12 2006-09-26 Myocor, Inc. Devices and methods for heart valve treatment
US7247134B2 (en) 2002-11-12 2007-07-24 Myocor, Inc. Devices and methods for heart valve treatment
US7485143B2 (en) 2002-11-15 2009-02-03 Abbott Cardiovascular Systems Inc. Apparatuses and methods for heart valve repair
US20040098116A1 (en) 2002-11-15 2004-05-20 Callas Peter L. Valve annulus constriction apparatus and method
US7316708B2 (en) 2002-12-05 2008-01-08 Cardiac Dimensions, Inc. Medical device delivery system
US20040133240A1 (en) 2003-01-07 2004-07-08 Cardiac Dimensions, Inc. Electrotherapy system, device, and method for treatment of cardiac valve dysfunction
US6997950B2 (en) 2003-01-16 2006-02-14 Chawla Surendra K Valve repair device
US20040158321A1 (en) 2003-02-12 2004-08-12 Cardiac Dimensions, Inc. Method of implanting a mitral valve therapy device
US7381210B2 (en) 2003-03-14 2008-06-03 Edwards Lifesciences Corporation Mitral valve repair system and method for use
EP1608297A2 (en) 2003-03-18 2005-12-28 St. Jude Medical, Inc. Body tissue remodeling apparatus

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