CA2276445A1 - Transdermal hormone-delivering therapeutic system - Google Patents

Transdermal hormone-delivering therapeutic system Download PDF

Info

Publication number
CA2276445A1
CA2276445A1 CA002276445A CA2276445A CA2276445A1 CA 2276445 A1 CA2276445 A1 CA 2276445A1 CA 002276445 A CA002276445 A CA 002276445A CA 2276445 A CA2276445 A CA 2276445A CA 2276445 A1 CA2276445 A1 CA 2276445A1
Authority
CA
Canada
Prior art keywords
therapeutic system
delivering therapeutic
transdermal hormone
active compound
transdermal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002276445A
Other languages
French (fr)
Other versions
CA2276445C (en
Inventor
Reinhold Meconi
Frank Seibertz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2276445A1 publication Critical patent/CA2276445A1/en
Application granted granted Critical
Publication of CA2276445C publication Critical patent/CA2276445C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins

Abstract

An active compound-containing patch for the controlled delivery of oestradiol or its pharmaceutically acceptable derivatives, alone or in combination with gestagens, to human or animal skin, having an active compound-containing reservoir based on contact adhesives comprising ethylcellulose and tackifying resins is characterized by a contact adhesive having a high plasticizer content.
CA002276445A 1997-01-14 1998-01-03 Transdermal hormone-delivering therapeutic system Expired - Fee Related CA2276445C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19700913A DE19700913C2 (en) 1997-01-14 1997-01-14 Transdermal therapeutic system for the delivery of hormones
DE19700913.1 1997-01-14
PCT/EP1998/000014 WO1998031349A1 (en) 1997-01-14 1998-01-03 Transdermal, hormone-delivering therapeutic system

Publications (2)

Publication Number Publication Date
CA2276445A1 true CA2276445A1 (en) 1998-07-23
CA2276445C CA2276445C (en) 2005-08-09

Family

ID=7817287

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002276445A Expired - Fee Related CA2276445C (en) 1997-01-14 1998-01-03 Transdermal hormone-delivering therapeutic system

Country Status (11)

Country Link
US (1) US6274165B1 (en)
EP (1) EP1007014B1 (en)
JP (1) JP3821855B2 (en)
KR (1) KR100561255B1 (en)
AT (1) ATE238778T1 (en)
AU (1) AU729494B2 (en)
CA (1) CA2276445C (en)
DE (2) DE19700913C2 (en)
ES (1) ES2201434T3 (en)
NO (1) NO993385L (en)
WO (1) WO1998031349A1 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19830651A1 (en) * 1998-07-09 2000-01-13 Lohmann Therapie Syst Lts Plaster containing steroids, process for its production and use
DE10054713C2 (en) * 1999-11-29 2002-07-18 Lohmann Therapie Syst Lts Transdermal therapeutic systems with improved stability and a method for their production
BRPI0015939B8 (en) * 1999-11-29 2021-05-25 Lts Lohmann Therapie Systeme Ag transdermal therapeutic system with improved stability and process for its preparation
US20020004065A1 (en) 2000-01-20 2002-01-10 David Kanios Compositions and methods to effect the release profile in the transdermal administration of active agents
DE10025970C2 (en) * 2000-05-25 2002-04-25 Lohmann Therapie Syst Lts Estrogen-containing plaster with an active substance reservoir based on ethyl cellulose and an ethylene-vinyl acetate-vinyl pyrrolidone copolymer and its use
WO2005030176A1 (en) 2003-09-29 2005-04-07 Novo Nordisk Femcare Ag Improved stability of progestogen formulations
HU227970B1 (en) 2007-07-10 2012-07-30 Egis Gyogyszergyar Nyrt Pharmaceutical compositions containing silicones of high volatility
CN103957899A (en) * 2011-11-04 2014-07-30 敏捷治疗公司 Dermal delivery compositions and methods
PL2782584T3 (en) 2011-11-23 2021-12-13 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
WO2013112947A1 (en) * 2012-01-26 2013-08-01 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10045935B2 (en) 2012-07-31 2018-08-14 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
US11154535B2 (en) 2012-07-31 2021-10-26 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10206932B2 (en) 2014-05-22 2019-02-19 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
AU2017239645A1 (en) 2016-04-01 2018-10-18 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4291014A (en) * 1979-01-11 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing estradiol diacetate
US4291015A (en) * 1979-08-14 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing a vasodilator
US4379454A (en) * 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
CN1021196C (en) 1986-12-29 1993-06-16 新泽西州州立大学(鲁杰斯) Prepn. method of progestin unit and system
US4906169A (en) * 1986-12-29 1990-03-06 Rutgers, The State University Of New Jersey Transdermal estrogen/progestin dosage unit, system and process
DE3743945A1 (en) * 1987-09-01 1989-03-09 Lohmann Gmbh & Co Kg DEVICE FOR DELIVERING SUBSTANCES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
US4994267A (en) * 1988-03-04 1991-02-19 Noven Pharmaceuticals, Inc. Transdermal acrylic multipolymer drug delivery system
DE3933460A1 (en) * 1989-10-06 1991-04-18 Lohmann Therapie Syst Lts OSTROGEN-ACTIVE PLASTER
DE4020144A1 (en) * 1990-06-25 1992-01-09 Lohmann Therapie Syst Lts Patches for topical or transdermal drug delivery - with adhesive layer contg. polyacrylate adhesive and film former
US5158734A (en) * 1991-02-27 1992-10-27 Minnesota Mining And Manufacturing Company Biomedical electrical connector using a socket receptacle having a resilient sheath
DE4230588C1 (en) * 1992-09-12 1993-10-07 Lohmann Therapie Syst Lts Dexpanthenol-containing plaster for the transdermal application of steroid hormones and process for its production
DE4333595A1 (en) * 1993-10-01 1995-04-06 Labtec Gmbh Transdermal therapeutic system for applying drugs to the skin
FR2717689B1 (en) * 1994-03-28 1996-07-05 Lhd Lab Hygiene Dietetique Transdermal matrix system for the administration of an estrogen and / or a progestin based on a styrene-isoprene-styrene copolymer.
FR2717688B1 (en) * 1994-03-28 1996-07-05 Lhd Lab Hygiene Dietetique Transdermal matrix system for administration of an estrogen and / or an EVA-based progestin.
JP3184534B2 (en) * 1994-10-05 2001-07-09 久光製薬株式会社 Medicinal compound comprising N-substituted-o-toluidine derivative and transdermal preparation
DE19500662C2 (en) * 1995-01-12 2001-04-26 Lohmann Therapie Syst Lts Plaster containing estradiol and its use

Also Published As

Publication number Publication date
EP1007014A1 (en) 2000-06-14
JP3821855B2 (en) 2006-09-13
NO993385D0 (en) 1999-07-08
ES2201434T3 (en) 2004-03-16
DE59808186D1 (en) 2003-06-05
US6274165B1 (en) 2001-08-14
DE19700913C2 (en) 2001-01-04
NO993385L (en) 1999-07-08
WO1998031349A1 (en) 1998-07-23
AU729494B2 (en) 2001-02-01
DE19700913A1 (en) 1998-07-16
JP2001508070A (en) 2001-06-19
CA2276445C (en) 2005-08-09
EP1007014B1 (en) 2003-05-02
KR100561255B1 (en) 2006-03-15
ATE238778T1 (en) 2003-05-15
AU5765498A (en) 1998-08-07
KR20000070178A (en) 2000-11-25

Similar Documents

Publication Publication Date Title
CA2276445A1 (en) Transdermal hormone-delivering therapeutic system
CA2181742A1 (en) Reduction of skin irritation during electrotransport delivery
CA2153572A1 (en) Transdermal therapeutic system with galanthamine as active ingredient
IE860306L (en) Drug delivery system
EP0679390A3 (en) Sprayable topical pharmaceutical compositions
EP0316065A3 (en) Improved transdermal drug delivery device
AU637637B2 (en) Estrogen-containing active substance plaster
PL315527A1 (en) Agent improving penetration of estradiol penetration in percutaneous administration thereof
AU3289589A (en) Occlusive body for administering a physiologically active substance
EP0195643A3 (en) Compositions and method of controlling transdermal penetration of topical and systemic agents
EP0177893A3 (en) Sustained release dosage form based on highly plasticized cellulose ether gels
ZA977832B (en) Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents.
IE900580L (en) Therapeutic system for the retarded and controlled¹transdermal or transmucous administration of active¹substances (ii)
HUT55220A (en) Process for producing pharmaceutical composition suitable for systemic administration through the skin and comprising deprenyl as active ingredient
EP0280737A4 (en) Steroidal drug-containing preparation for external use.
EP0513702A3 (en) Melatonin derivaties for use in the therapy of sleep disorders and in pre-anaesthetic medication
CA2209711A1 (en) Plaster containing estradiol
AU7085996A (en) Therapeutic preparation for the transdermal application of active substances through the skin
CA2338859A1 (en) Estradiol-containing patch for transdermal administration of hormones
CA2251966A1 (en) Transdermally administered dextromethorphan as antitussive agent
CA2387143A1 (en) Transdermal therapeutic system containing tulobuterol hydrochloride for administering the bronchodilator tulobuterol via the skin
CA2200189A1 (en) Scopolamine plaster
WO1996040074A3 (en) Device for releasing aggregation-stabilized, biologically active agent
WO1994025025A3 (en) Systems for controlled release of pilocarpine
ZA987006B (en) Transdermal therapeutic system (TTS) for delivering active ingredient through the skin to a body and method for application to the skin

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20140103