CA2279992A1 - Laser capture microdissection method and apparatus - Google Patents

Laser capture microdissection method and apparatus Download PDF

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Publication number
CA2279992A1
CA2279992A1 CA002279992A CA2279992A CA2279992A1 CA 2279992 A1 CA2279992 A1 CA 2279992A1 CA 002279992 A CA002279992 A CA 002279992A CA 2279992 A CA2279992 A CA 2279992A CA 2279992 A1 CA2279992 A1 CA 2279992A1
Authority
CA
Canada
Prior art keywords
laser capture
capture microdissection
sample
transfer film
transfer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002279992A
Other languages
French (fr)
Other versions
CA2279992C (en
Inventor
Thomas M. Baer
Mark A. Enright
David F. Head
Christopher E. Todd
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Life Technologies Corp
Original Assignee
Arcturus Engineering, Inc.
Thomas M. Baer
Mark A. Enright
David F. Head
Christopher E. Todd
Arcturus Bioscience, Inc.
Molecular Devices Corporation
Mds Analytical Technologies (Us) Inc.
Molecular Devices, Inc.
Life Technologies Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arcturus Engineering, Inc., Thomas M. Baer, Mark A. Enright, David F. Head, Christopher E. Todd, Arcturus Bioscience, Inc., Molecular Devices Corporation, Mds Analytical Technologies (Us) Inc., Molecular Devices, Inc., Life Technologies Corporation filed Critical Arcturus Engineering, Inc.
Publication of CA2279992A1 publication Critical patent/CA2279992A1/en
Application granted granted Critical
Publication of CA2279992C publication Critical patent/CA2279992C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/32—Micromanipulators structurally combined with microscopes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2806—Means for preparing replicas of specimens, e.g. for microscopal analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G01N2001/2833—Collecting samples on a sticky, tacky, adhesive surface
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
    • G01N2001/2833—Collecting samples on a sticky, tacky, adhesive surface
    • G01N2001/284—Collecting samples on a sticky, tacky, adhesive surface using local activation of adhesive, i.e. Laser Capture Microdissection

Abstract

Systems and methods for laser capture microdissection are disclosed. A method of laser capture microdissection includes providing a sample that is to undergo laser capture microdissection; positioning said sample within an optical axis of a laser capture microdissection instrument; providing a transfer film carrier having a substrate surface and a laser capture microdissection transfer film coupled to said substrate surface; placing said laser capture microdissection transfer film in juxtaposition with said sample with a pressure sufficient to allow laser capture microdissection transfer of a portion of said sample to said laser capture microdissection transfer film, without forcing nonspecific transfer of a remainder of said sample to said laser capture microdissection film; and then transferring a portion of said sample to said laser capture microdissection transfer film, without forcing nonspecific transfer of a remainder of said sample to said laser capture microdissection transfer film. The systems and methods provide the advantages of increased speed and much lower rates of contamination.
CA002279992A 1997-02-07 1998-02-05 Laser capture microdissection method and apparatus Expired - Fee Related CA2279992C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US3786497P 1997-02-07 1997-02-07
US60/037,864 1997-02-07
US6073197P 1997-10-01 1997-10-01
US60/060,731 1997-10-01
US09/018,452 1998-02-04
US09/018,452 US6469779B2 (en) 1997-02-07 1998-02-04 Laser capture microdissection method and apparatus
PCT/US1998/002388 WO1998035216A1 (en) 1997-02-07 1998-02-05 Laser capture microdissection method and apparatus

Publications (2)

Publication Number Publication Date
CA2279992A1 true CA2279992A1 (en) 1998-08-13
CA2279992C CA2279992C (en) 2009-10-06

Family

ID=27361026

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002279992A Expired - Fee Related CA2279992C (en) 1997-02-07 1998-02-05 Laser capture microdissection method and apparatus

Country Status (8)

Country Link
US (10) US6469779B2 (en)
EP (1) EP0958491B1 (en)
JP (1) JP3786711B2 (en)
AT (2) ATE239215T1 (en)
AU (1) AU6150398A (en)
CA (1) CA2279992C (en)
DE (2) DE69814041T2 (en)
WO (1) WO1998035216A1 (en)

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US20010001574A1 (en) 2001-05-24
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US20040027556A1 (en) 2004-02-12
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US6697149B2 (en) 2004-02-24
CA2279992C (en) 2009-10-06

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