CA2280099A1 - Medical aerosol formulations - Google Patents

Medical aerosol formulations Download PDF

Info

Publication number
CA2280099A1
CA2280099A1 CA002280099A CA2280099A CA2280099A1 CA 2280099 A1 CA2280099 A1 CA 2280099A1 CA 002280099 A CA002280099 A CA 002280099A CA 2280099 A CA2280099 A CA 2280099A CA 2280099 A1 CA2280099 A1 CA 2280099A1
Authority
CA
Canada
Prior art keywords
aerosol formulations
hydrofluoroalkanes
carbon dioxide
active compounds
pressure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002280099A
Other languages
French (fr)
Other versions
CA2280099C (en
Inventor
Manfred Keller
Kurt Herzog
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jagotec AG
Original Assignee
Jago Pharma Ag
Manfred Keller
Kurt Herzog
Skyepharma Ag
Jago Research Ag
Jagotec Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jago Pharma Ag, Manfred Keller, Kurt Herzog, Skyepharma Ag, Jago Research Ag, Jagotec Ag filed Critical Jago Pharma Ag
Publication of CA2280099A1 publication Critical patent/CA2280099A1/en
Application granted granted Critical
Publication of CA2280099C publication Critical patent/CA2280099C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/124—Aerosols; Foams characterised by the propellant

Abstract

A pressure-liquefied propellant mixture for aerosols, comprising a fluorinated alkane, in particular 1,1,1,2-tetrafluoroethane and/or 1,1,1,2,3,3,3-heptafluoropropane, and carbon dioxide, makes possible an improvement of the wetting properties of pharmaceutically active compounds, with which the formulation problems existing with hydrofluoroalkanes in relation to suspension as we11 as solution aerosols can be overcome and thus improved medicinal aerosol formulations can be obtained. With the aid of carbon dioxide, it is also possible to specifically influence the pressure and thus the particle size distribution and also by displacement of oxygen from the hydrofluoroalkanes to improve the storage stability of oxidation-sensitive active compounds.
CA002280099A 1997-02-05 1998-02-02 Medical aerosol formulations Expired - Fee Related CA2280099C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH24897 1997-02-05
CH248/97 1997-02-05
PCT/CH1998/000037 WO1998034595A1 (en) 1997-02-05 1998-02-02 Medical aerosol formulations

Publications (2)

Publication Number Publication Date
CA2280099A1 true CA2280099A1 (en) 1998-08-13
CA2280099C CA2280099C (en) 2005-12-27

Family

ID=4182679

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002280099A Expired - Fee Related CA2280099C (en) 1997-02-05 1998-02-02 Medical aerosol formulations

Country Status (14)

Country Link
US (1) US6461591B1 (en)
EP (1) EP1014943B1 (en)
JP (1) JP2001511160A (en)
AT (1) ATE219355T1 (en)
AU (1) AU718967B2 (en)
CA (1) CA2280099C (en)
DE (1) DE59804534D1 (en)
DK (1) DK1014943T3 (en)
ES (1) ES2178817T3 (en)
NO (1) NO993773L (en)
NZ (1) NZ337065A (en)
PT (1) PT1014943E (en)
WO (1) WO1998034595A1 (en)
ZA (1) ZA98937B (en)

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Also Published As

Publication number Publication date
ZA98937B (en) 1998-08-06
DE59804534D1 (en) 2002-07-25
PT1014943E (en) 2002-11-29
US6461591B1 (en) 2002-10-08
NO993773D0 (en) 1999-08-04
CA2280099C (en) 2005-12-27
ES2178817T3 (en) 2003-01-01
EP1014943B1 (en) 2002-06-19
ATE219355T1 (en) 2002-07-15
AU718967B2 (en) 2000-05-04
NZ337065A (en) 2001-02-23
DK1014943T3 (en) 2002-10-14
AU5649698A (en) 1998-08-26
WO1998034595A1 (en) 1998-08-13
EP1014943A1 (en) 2000-07-05
JP2001511160A (en) 2001-08-07
NO993773L (en) 1999-10-04

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Effective date: 20170202