CA2282407A1 - Methods and compositions for optimization of oxygen transport by cell-free systems - Google Patents

Methods and compositions for optimization of oxygen transport by cell-free systems Download PDF

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Publication number
CA2282407A1
CA2282407A1 CA002282407A CA2282407A CA2282407A1 CA 2282407 A1 CA2282407 A1 CA 2282407A1 CA 002282407 A CA002282407 A CA 002282407A CA 2282407 A CA2282407 A CA 2282407A CA 2282407 A1 CA2282407 A1 CA 2282407A1
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CA
Canada
Prior art keywords
methods
compositions
oxygen
optimization
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002282407A
Other languages
French (fr)
Other versions
CA2282407C (en
Inventor
Robert M. Winslow
Marcos Intaglietta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
The Regents Of The University Of California
Robert M. Winslow
Marcos Intaglietta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California, Robert M. Winslow, Marcos Intaglietta filed Critical The Regents Of The University Of California
Publication of CA2282407A1 publication Critical patent/CA2282407A1/en
Application granted granted Critical
Publication of CA2282407C publication Critical patent/CA2282407C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/813—Carrier is a saccharide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/815—Carrier is a synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood

Abstract

Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use thereof. The oxygen-carrying component may consist of and hemoglobin-based oxygen carrier, while the non-oxygen carrying plasma expander may consist of any suitable diluent.
CA002282407A 1997-02-28 1998-02-27 Methods and compositions for optimization of oxygen transport by cell-free systems Expired - Fee Related CA2282407C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/810,694 1997-02-28
US08/810,694 US5814601A (en) 1997-02-28 1997-02-28 Methods and compositions for optimization of oxygen transport by cell-free systems
PCT/US1998/003846 WO1998037909A1 (en) 1997-02-28 1998-02-27 Methods and compositions for optimization of oxygen transport by cell-free systems
USUNKNOWN 1999-06-07

Publications (2)

Publication Number Publication Date
CA2282407A1 true CA2282407A1 (en) 1998-09-03
CA2282407C CA2282407C (en) 2004-10-26

Family

ID=25204449

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002282407A Expired - Fee Related CA2282407C (en) 1997-02-28 1998-02-27 Methods and compositions for optimization of oxygen transport by cell-free systems

Country Status (3)

Country Link
US (1) US5814601A (en)
CA (1) CA2282407C (en)
WO (1) WO1998037909A1 (en)

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US6875423B1 (en) 1999-09-21 2005-04-05 Marcos Intaglietta Methods for increasing peripheral blood circulation
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US9044178B2 (en) 2007-08-30 2015-06-02 Pepex Biomedical, Llc Electrochemical sensor and method for manufacturing
WO2009032760A2 (en) 2007-08-30 2009-03-12 Pepex Biomedical Llc Electrochmical sensor and method for manufacturing
US7989593B1 (en) 2010-05-27 2011-08-02 Bing Lou Wong Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof
US8048856B1 (en) 2010-06-23 2011-11-01 Billion King, Ltd. Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition
US7932356B1 (en) 2010-06-23 2011-04-26 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition
US8084581B1 (en) 2011-04-29 2011-12-27 Bing Lou Wong Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus
WO2012159040A2 (en) 2011-05-19 2012-11-22 Pepex Biomedical Inc. Fluid management and patient monitoring system
US20130052232A1 (en) 2011-08-31 2013-02-28 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking
WO2014089058A1 (en) 2012-12-03 2014-06-12 Pepex Biomedical, Inc. Sensor module and method of using a sensor module
US11045124B2 (en) 2014-06-04 2021-06-29 Pepex Biomedical, Inc. Electrochemical sensors and methods for making electrochemical sensors using advanced printing technology

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Also Published As

Publication number Publication date
CA2282407C (en) 2004-10-26
US5814601A (en) 1998-09-29
WO1998037909A1 (en) 1998-09-03
WO1998037909A9 (en) 1999-11-18

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