US6582959B2
(en)
|
1991-03-29 |
2003-06-24 |
Genentech, Inc. |
Antibodies to vascular endothelial cell growth factor
|
US6358709B1
(en)
|
1995-12-07 |
2002-03-19 |
Diversa Corporation |
End selection in directed evolution
|
US6537776B1
(en)
|
1999-06-14 |
2003-03-25 |
Diversa Corporation |
Synthetic ligation reassembly in directed evolution
|
US6352842B1
(en)
|
1995-12-07 |
2002-03-05 |
Diversa Corporation |
Exonucease-mediated gene assembly in directed evolution
|
US7018793B1
(en)
|
1995-12-07 |
2006-03-28 |
Diversa Corporation |
Combinatorial screening of mixed populations of organisms
|
US6562594B1
(en)
|
1999-09-29 |
2003-05-13 |
Diversa Corporation |
Saturation mutagenesis in directed evolution
|
US6238884B1
(en)
|
1995-12-07 |
2001-05-29 |
Diversa Corporation |
End selection in directed evolution
|
US6939689B2
(en)
|
1995-12-07 |
2005-09-06 |
Diversa Corporation |
Exonuclease-mediated nucleic acid reassembly in directed evolution
|
US5830696A
(en)
|
1996-12-05 |
1998-11-03 |
Diversa Corporation |
Directed evolution of thermophilic enzymes
|
US6740506B2
(en)
|
1995-12-07 |
2004-05-25 |
Diversa Corporation |
End selection in directed evolution
|
US6361974B1
(en)
|
1995-12-07 |
2002-03-26 |
Diversa Corporation |
Exonuclease-mediated nucleic acid reassembly in directed evolution
|
US6713279B1
(en)
|
1995-12-07 |
2004-03-30 |
Diversa Corporation |
Non-stochastic generation of genetic vaccines and enzymes
|
US6171820B1
(en)
*
|
1995-12-07 |
2001-01-09 |
Diversa Corporation |
Saturation mutagenesis in directed evolution
|
US7122636B1
(en)
|
1997-02-21 |
2006-10-17 |
Genentech, Inc. |
Antibody fragment-polymer conjugates and uses of same
|
JP3521382B2
(en)
|
1997-02-27 |
2004-04-19 |
日本たばこ産業株式会社 |
Cell surface molecules that mediate cell-cell adhesion and signal transduction
|
US7112655B1
(en)
|
1997-02-27 |
2006-09-26 |
Japan Tobacco, Inc. |
JTT-1 protein and methods of inhibiting lymphocyte activation
|
US7365166B2
(en)
*
|
1997-04-07 |
2008-04-29 |
Genentech, Inc. |
Anti-VEGF antibodies
|
ES2236634T3
(en)
|
1997-04-07 |
2005-07-16 |
Genentech, Inc. |
ANTI-VEGF ANTIBODIES.
|
US20020032315A1
(en)
*
|
1997-08-06 |
2002-03-14 |
Manuel Baca |
Anti-vegf antibodies
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
US6887674B1
(en)
|
1998-04-13 |
2005-05-03 |
California Institute Of Technology |
Artery- and vein-specific proteins and uses therefor
|
US6864227B1
(en)
|
1998-04-13 |
2005-03-08 |
California Institute Of Technology |
Artery-and vein-specific proteins and uses therefor
|
JP2002530081A
(en)
*
|
1998-11-18 |
2002-09-17 |
ジェネンテック・インコーポレーテッド |
Antibody variants with higher binding affinity than the parent antibody
|
EP1950300A3
(en)
|
1998-11-18 |
2011-03-23 |
Genentech, Inc. |
Antibody variants with higher binding affinity compared to parent antibodies
|
WO2000034337A1
(en)
*
|
1998-12-10 |
2000-06-15 |
Tsukuba Research Laboratory, Toagosei Co., Ltd. |
Humanized monoclonal antibodies against vascular endothelial cell growth factor
|
IL143596A0
(en)
*
|
1998-12-22 |
2002-04-21 |
Genentech Inc |
Vascular endothelial cell growth factor antagonists and uses thereof
|
US7183387B1
(en)
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
CN1308347C
(en)
*
|
1999-04-28 |
2007-04-04 |
德克萨斯大学董事会 |
Compositions and methods for cancer treatment by selectively inhibiting VEGF
|
US6703020B1
(en)
|
1999-04-28 |
2004-03-09 |
Board Of Regents, The University Of Texas System |
Antibody conjugate methods for selectively inhibiting VEGF
|
EP1203026A4
(en)
*
|
1999-07-29 |
2005-03-16 |
Dyax Corp |
Binding moieties for fibrin
|
JP4210454B2
(en)
|
2001-03-27 |
2009-01-21 |
日本たばこ産業株式会社 |
Inflammatory bowel disease treatment
|
JP3871503B2
(en)
|
1999-08-30 |
2007-01-24 |
日本たばこ産業株式会社 |
Immune disease treatment
|
US7608681B2
(en)
|
1999-12-24 |
2009-10-27 |
Genentech, Inc. |
Methods and compositions for prolonging elimination half-times of bioactive compounds
|
EP1757701A1
(en)
|
1999-12-24 |
2007-02-28 |
Genentech, Inc. |
Methods and compositions for prolonging elimination half-times of bioactive compounds
|
US20040002068A1
(en)
|
2000-03-01 |
2004-01-01 |
Corixa Corporation |
Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
|
JP3597140B2
(en)
|
2000-05-18 |
2004-12-02 |
日本たばこ産業株式会社 |
Human monoclonal antibody against costimulatory molecule AILIM and pharmaceutical use thereof
|
CA2648048A1
(en)
|
2000-06-23 |
2002-01-03 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
|
EP2042597B1
(en)
|
2000-06-23 |
2014-05-07 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
|
US6989138B2
(en)
|
2000-10-24 |
2006-01-24 |
Diatide, Inc. |
Stabilization of radiopharmaceutical compositions using hydrophilic thioethers and hydrophilic 6-hydroxy chromans
|
US6902718B2
(en)
|
2000-10-24 |
2005-06-07 |
Diatide, Inc. |
Stabilization of radiopharmaceutical compositions using hydrophilic thioethers
|
JP4212278B2
(en)
|
2001-03-01 |
2009-01-21 |
日本たばこ産業株式会社 |
Graft rejection inhibitor
|
US7667004B2
(en)
|
2001-04-17 |
2010-02-23 |
Abmaxis, Inc. |
Humanized antibodies against vascular endothelial growth factor
|
US7117096B2
(en)
|
2001-04-17 |
2006-10-03 |
Abmaxis, Inc. |
Structure-based selection and affinity maturation of antibody library
|
TWI284539B
(en)
|
2001-07-30 |
2007-08-01 |
Epix Pharm Inc |
A method for making a magnetic resonance (MR) imaging agent, a MR imaging contrast agent, a method for altering stability of a peptide and a modified peptide
|
US20050123925A1
(en)
|
2002-11-15 |
2005-06-09 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
KR100988949B1
(en)
*
|
2001-10-25 |
2010-10-20 |
제넨테크, 인크. |
Glycoprotein compositions
|
US20030190705A1
(en)
*
|
2001-10-29 |
2003-10-09 |
Sunol Molecular Corporation |
Method of humanizing immune system molecules
|
US6870034B2
(en)
|
2002-02-05 |
2005-03-22 |
Genentech, Inc. |
Protein purification
|
US10022078B2
(en)
|
2004-07-13 |
2018-07-17 |
Dexcom, Inc. |
Analyte sensor
|
HUE025101T2
(en)
|
2002-04-26 |
2016-02-29 |
Genentech Inc |
Non-affinity purification of proteins
|
EP2316922B1
(en)
|
2002-05-24 |
2013-05-22 |
Merck Sharp & Dohme Corp. |
Neutralizing human anti-IGFR antibody
|
US9028822B2
(en)
|
2002-06-28 |
2015-05-12 |
Domantis Limited |
Antagonists against TNFR1 and methods of use therefor
|
US7696320B2
(en)
|
2004-08-24 |
2010-04-13 |
Domantis Limited |
Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
|
EP2263697A3
(en)
|
2002-07-15 |
2011-01-19 |
Board of Regents, The University of Texas System |
Duramycin peptide binding to anionic phospholipids and aminophospholipids conjugates and their use in treating viral infections
|
USRE47770E1
(en)
|
2002-07-18 |
2019-12-17 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
ES2442615T5
(en)
|
2002-07-18 |
2023-03-16 |
Merus Nv |
Recombinant production of antibody mixtures
|
WO2004065417A2
(en)
*
|
2003-01-23 |
2004-08-05 |
Genentech, Inc. |
Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture
|
EP2192172B1
(en)
|
2003-02-03 |
2014-12-03 |
iBio, Inc. |
System for expression of genes in plants
|
US7381410B2
(en)
|
2003-03-12 |
2008-06-03 |
Vasgene Therapeutics, Inc. |
Polypeptide compounds for inhibiting angiogenesis and tumor growth
|
CA2518912A1
(en)
|
2003-03-12 |
2004-09-23 |
Vasgene Therapeutics, Inc. |
Polypeptide compounds for inhibiting angiogenesis and tumor growth
|
WO2008109433A2
(en)
|
2007-03-02 |
2008-09-12 |
The Cleveland Clinic Foundation |
Anti-angiogenic peptides
|
EP1664322B1
(en)
|
2003-05-22 |
2013-07-10 |
Fraunhofer USA, Inc. |
Recombinant carrier molecule for expression, delivery and purification of target polypeptides
|
JP2007525466A
(en)
*
|
2003-05-30 |
2007-09-06 |
ジェネンテック・インコーポレーテッド |
Treatment with anti-VEGF antibody
|
US20100069614A1
(en)
|
2008-06-27 |
2010-03-18 |
Merus B.V. |
Antibody producing non-human mammals
|
ES2408582T3
(en)
*
|
2003-05-30 |
2013-06-21 |
Merus B.V. |
Fab library for the preparation of a mixture of antibodies
|
DK1648940T3
(en)
|
2003-07-28 |
2016-08-15 |
Genentech Inc |
Reduction of leaching of protein A during protein A affinity chromatography
|
US20050106667A1
(en)
|
2003-08-01 |
2005-05-19 |
Genentech, Inc |
Binding polypeptides with restricted diversity sequences
|
KR20060069825A
(en)
*
|
2003-08-01 |
2006-06-22 |
제넨테크, 인크. |
Antibody cdr polypeptide sequences with restricted diversity
|
US7758859B2
(en)
|
2003-08-01 |
2010-07-20 |
Genentech, Inc. |
Anti-VEGF antibodies
|
US7920906B2
(en)
|
2005-03-10 |
2011-04-05 |
Dexcom, Inc. |
System and methods for processing analyte sensor data for sensor calibration
|
CA2903196A1
(en)
|
2003-08-27 |
2005-03-10 |
Ophthotech Corporation |
Combination therapy for the treatment of ocular neovascular disorders
|
FR2859725B1
(en)
*
|
2003-09-16 |
2006-03-10 |
Neovacs |
HIGH EFFICIENCY PROCESS FOR OBTAINING HUMAN ANTIBODIES THAT NEUTRALIZE THE BIOLOGICAL ACTIVITY OF A HUMAN CYTOKINE
|
US9247900B2
(en)
|
2004-07-13 |
2016-02-02 |
Dexcom, Inc. |
Analyte sensor
|
JP5912211B2
(en)
|
2004-01-20 |
2016-04-27 |
メルス ビー.ヴィー. |
Mixture of binding proteins
|
ATE452147T1
(en)
|
2004-02-19 |
2010-01-15 |
Genentech Inc |
ANTIBODIES WITH CORRECTED CDR
|
DK1730196T3
(en)
|
2004-03-12 |
2011-03-28 |
Vasgene Therapeutics Inc |
EphB4-binding antibodies to inhibit antiogenesis and tumor growth
|
CN101072797B
(en)
|
2004-03-12 |
2012-05-09 |
瓦斯基因治疗公司 |
Antibody binding EPHB4, inhibiting angiogenesis and tumor growth
|
JP2008500830A
(en)
|
2004-06-01 |
2008-01-17 |
ドマンティス リミテッド |
Bispecific fusion antibodies with increased serum half-life
|
US20060020192A1
(en)
|
2004-07-13 |
2006-01-26 |
Dexcom, Inc. |
Transcutaneous analyte sensor
|
CN101044164A
(en)
*
|
2004-07-20 |
2007-09-26 |
健泰科生物技术公司 |
Inhibitors of angiopoietin-like 4 protein, combinations, and their use
|
US8604185B2
(en)
|
2004-07-20 |
2013-12-10 |
Genentech, Inc. |
Inhibitors of angiopoietin-like 4 protein, combinations, and their use
|
ZA200700947B
(en)
|
2004-07-23 |
2008-06-25 |
Genentech Inc |
Crystallization of antibodies or fragments thereof
|
US7662926B2
(en)
|
2004-09-02 |
2010-02-16 |
Genentech, Inc. |
Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor
|
US7655229B2
(en)
|
2004-09-02 |
2010-02-02 |
Chan Andrew C |
Anti-FC-gamma RIIB receptor antibody and uses therefor
|
EP1799713B1
(en)
|
2004-09-23 |
2014-11-05 |
VasGene Therapeutics, Inc. |
Polypeptide compounds for inhibiting angiogenesis and tumor growth
|
WO2006047325A1
(en)
|
2004-10-21 |
2006-05-04 |
Genentech, Inc. |
Method for treating intraocular neovascular diseases
|
RU2441071C2
(en)
|
2004-12-22 |
2012-01-27 |
Дженентек, Инк. |
Method for producing soluble multipass transmembrane proteins
|
JP5057994B2
(en)
*
|
2005-01-06 |
2012-10-24 |
ジーイー・ヘルスケア・アクスイェ・セルスカプ |
Optical imaging
|
US20070166388A1
(en)
|
2005-02-18 |
2007-07-19 |
Desai Neil P |
Combinations and modes of administration of therapeutic agents and combination therapy
|
DK2301531T3
(en)
|
2005-02-18 |
2018-07-30 |
Abraxis Bioscience Llc |
COMBINATIONS AND WAYS FOR ADMINISTRATING THERAPEUTIC SUBSTANCES AND COMBINATION THERAPY
|
US8735394B2
(en)
|
2005-02-18 |
2014-05-27 |
Abraxis Bioscience, Llc |
Combinations and modes of administration of therapeutic agents and combination therapy
|
US20160355591A1
(en)
|
2011-05-02 |
2016-12-08 |
Immunomedics, Inc. |
Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
|
EP1861116B1
(en)
|
2005-03-25 |
2015-09-16 |
Regeneron Pharmaceuticals, Inc. |
Vegf antagonist formulations
|
CN101222926B
(en)
*
|
2005-04-15 |
2013-07-17 |
默沙东公司 |
Methods and compositions for treating or preventing cancer
|
EP1895947A2
(en)
*
|
2005-06-17 |
2008-03-12 |
Abbott Laboratories |
Improved method of treating degenerative spinal disorders
|
PT2135881E
(en)
*
|
2005-06-20 |
2011-12-21 |
Genentech Inc |
Antibodies binding to the tumour associated antigen tat10772 for the diagnosis and treatment of tumor
|
USRE47223E1
(en)
|
2005-06-20 |
2019-02-05 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
CN101378781B
(en)
|
2005-08-03 |
2013-08-07 |
美国弗劳恩霍夫股份有限公司 |
Compositions and methods for production of immunoglobulins
|
ES2718323T3
(en)
|
2005-08-31 |
2019-07-01 |
Abraxis Bioscience Llc |
Compositions comprising low water soluble pharmaceutical agents
|
UA96139C2
(en)
|
2005-11-08 |
2011-10-10 |
Дженентек, Інк. |
Anti-neuropilin-1 (nrp1) antibody
|
KR100877824B1
(en)
|
2005-11-11 |
2009-01-12 |
한국생명공학연구원 |
E2EPF ubiquitin carrier protein-von Hippel-Lindau interaction and uses of thereof
|
CA2629815C
(en)
*
|
2005-11-14 |
2014-08-12 |
University Of Southern California |
Integrin-binding small molecules
|
US20100056439A1
(en)
*
|
2005-12-06 |
2010-03-04 |
Domantis Limited |
Ligands that have binding specificity for egfr and/or vegf and methods of use therefor
|
WO2007070671A2
(en)
†
|
2005-12-16 |
2007-06-21 |
Regeneron Pharmaceuticals, Inc. |
Therapeutic methods for inhibiting tumor growth with dll4 antagonists
|
PT1973950E
(en)
|
2006-01-05 |
2014-12-29 |
Genentech Inc |
Anti-ephb4 antibodies and methods using the same
|
EP1976884B1
(en)
|
2006-01-20 |
2012-12-19 |
Genentech, Inc. |
Anti-ephrinb2 antibodies and methods using same
|
AU2007215080A1
(en)
|
2006-02-13 |
2007-08-23 |
Fraunhofer Usa, Inc. |
Influenza antigens, vaccine compositions, and related methods
|
AR059851A1
(en)
|
2006-03-16 |
2008-04-30 |
Genentech Inc |
ANTIBODIES OF EGFL7 AND METHODS OF USE
|
EP2366716A3
(en)
|
2006-03-21 |
2011-11-16 |
Genentech, Inc. |
Combinatorial therapy involving alpha5beta1 antagonists
|
CN101405030B
(en)
*
|
2006-03-22 |
2013-03-13 |
霍夫曼-拉罗奇有限公司 |
Use of an antibody for vascular endothelial groeth factor and an antibody for human epithelial growth factor receptor type 2 in preparing kit for tumor therapy
|
TW200812615A
(en)
|
2006-03-22 |
2008-03-16 |
Hoffmann La Roche |
Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
|
KR20080106946A
(en)
*
|
2006-03-29 |
2008-12-09 |
제넨테크, 인크. |
Diagnostics and treatments for tumors
|
KR101482483B1
(en)
|
2006-04-07 |
2015-01-15 |
에르피오 세러퓨틱스 인코포레이티드 |
Antibodies that bind human protein tyrosine phosphatase beta (hptpbeta) and uses thereof
|
RU2008152435A
(en)
*
|
2006-06-06 |
2010-07-20 |
Дженентек, Инк. (Us) |
COMPOSITIONS AND METHODS OF REGULATING VESSEL DEVELOPMENT
|
AU2007319672B2
(en)
|
2006-06-06 |
2011-06-30 |
Genentech, Inc. |
Anti-DLL4 antibodies and methods using same
|
SI2944306T1
(en)
|
2006-06-16 |
2021-04-30 |
Regeneron Pharmaceuticals, Inc. |
Vegf antagonist formulations suitable for intravitreal administration
|
FR2902799B1
(en)
|
2006-06-27 |
2012-10-26 |
Millipore Corp |
METHOD AND UNIT FOR PREPARING A SAMPLE FOR THE MICROBIOLOGICAL ANALYSIS OF A LIQUID
|
EP2068877A4
(en)
|
2006-07-19 |
2011-09-21 |
Cleveland Clinic Foundation |
Compounds and methods of modulating angiogenesis
|
CN100448892C
(en)
*
|
2006-08-02 |
2009-01-07 |
中国人民解放军军事医学科学院基础医学研究所 |
Antitumour vascular endothelial growth factor receptor VEGF-R antigen and its coding gene and application
|
EP2441472B1
(en)
|
2006-08-21 |
2015-06-10 |
F. Hoffmann-La Roche AG |
Tumor therapy with an anti-VEGF antibody
|
EP3357932A1
(en)
|
2006-09-29 |
2018-08-08 |
OncoMed Pharmaceuticals, Inc. |
Compositions and methods for diagnosing and treating cancer
|
EP2457929B1
(en)
|
2006-10-04 |
2016-06-08 |
Genentech, Inc. |
ELISA for VEGF
|
MX2009004027A
(en)
*
|
2006-10-20 |
2009-09-28 |
Schering Corp |
Fully human anti-vegf antibodies and methods of using.
|
KR20150097813A
(en)
|
2006-12-19 |
2015-08-26 |
제넨테크, 인크. |
Vegf-specific antagonists for adjuvant and neoadjuvant therapy and the treatment of early stage tumors
|
US8362217B2
(en)
|
2006-12-21 |
2013-01-29 |
Emd Millipore Corporation |
Purification of proteins
|
US8163886B2
(en)
|
2006-12-21 |
2012-04-24 |
Emd Millipore Corporation |
Purification of proteins
|
US8569464B2
(en)
|
2006-12-21 |
2013-10-29 |
Emd Millipore Corporation |
Purification of proteins
|
AU2008209404B2
(en)
|
2007-01-22 |
2012-08-16 |
Genentech, Inc. |
Polyelectrolyte precipitation and purification of antibodies
|
JP2010517944A
(en)
*
|
2007-01-26 |
2010-05-27 |
バイオインヴェント インターナショナル アーベー |
DLL4 signaling inhibitor and use thereof
|
US7834154B2
(en)
|
2007-02-09 |
2010-11-16 |
Genentech, Inc. |
Anti-ROBO4 antibodies and uses therefor
|
CA2683568A1
(en)
|
2007-05-08 |
2008-11-20 |
Genentech, Inc. |
Cysteine engineered anti-muc16 antibodies and antibody drug conjugates
|
JP5745840B2
(en)
|
2007-05-17 |
2015-07-08 |
ジェネンテック, インコーポレイテッド |
Inhibition of tumor metastasis by anti-neuropilin 2 antibody
|
PE20090321A1
(en)
|
2007-06-04 |
2009-04-20 |
Genentech Inc |
ANTI-NOTCH1 NRR ANTIBODIES, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITION
|
DK3597659T3
(en)
|
2007-07-09 |
2023-04-03 |
Genentech Inc |
Prevention of disulfide bond reduction during recombinant production of polypeptides
|
CA2692933C
(en)
|
2007-07-11 |
2016-10-18 |
Fraunhofer Usa, Inc. |
Yersinia pestis antigens, vaccine compositions, and related methods
|
WO2009023185A1
(en)
|
2007-08-13 |
2009-02-19 |
Vasgene Therapeutics, Inc. |
Cancer treatment using humanized antibodies that bind to ephb4
|
EP2190861A4
(en)
|
2007-08-22 |
2011-03-30 |
Univ California |
Activatable binding polypeptides and methods of identification and use thereof
|
RU2498991C2
(en)
|
2007-10-30 |
2013-11-20 |
Дженентек, Инк. |
Purification of antibodies with cation-exchange chromatography
|
EP2219672B1
(en)
|
2007-11-09 |
2016-02-17 |
Peregrine Pharmaceuticals, Inc. |
Anti-vegf antibody compositions and methods
|
WO2009061807A2
(en)
|
2007-11-09 |
2009-05-14 |
Genentech, Inc. |
Activin receptor-like kinase-1 compositions and methods of use
|
TWI580694B
(en)
|
2007-11-30 |
2017-05-01 |
建南德克公司 |
Anti-vegf antibodies
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
US8663643B2
(en)
|
2008-03-18 |
2014-03-04 |
Genentech, Inc. |
Combinations of an anti-HER2 antibody-drug conjugate and chemotherapeutic agents, and methods of use
|
EP2274008B1
(en)
*
|
2008-03-27 |
2014-02-26 |
ZymoGenetics, Inc. |
Compositions and methods for inhibiting pdgfrbeta and vegf-a
|
EP2280997A2
(en)
*
|
2008-04-18 |
2011-02-09 |
Xencor, Inc. |
Human equivalent monoclonal antibodies engineered from nonhuman variable regions
|
BRPI0910482A2
(en)
|
2008-04-29 |
2019-09-24 |
Abbott Lab |
double variable domain immunoglobins and their uses
|
EP2297209A4
(en)
|
2008-06-03 |
2012-08-01 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
SG191625A1
(en)
|
2008-06-03 |
2013-07-31 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
WO2009151514A1
(en)
|
2008-06-11 |
2009-12-17 |
Millipore Corporation |
Stirred tank bioreactor
|
PL2307454T3
(en)
|
2008-06-25 |
2017-07-31 |
Esbatech, An Alcon Biomedical Research Unit Llc |
Stable and soluble antibodies inhibiting vegf
|
US8822645B2
(en)
*
|
2008-07-08 |
2014-09-02 |
Abbvie Inc. |
Prostaglandin E2 dual variable domain immunoglobulins and uses thereof
|
US20100029491A1
(en)
*
|
2008-07-11 |
2010-02-04 |
Maike Schmidt |
Methods and compositions for diagnostic use for tumor treatment
|
JP5606438B2
(en)
|
2008-07-23 |
2014-10-15 |
エフ.ホフマン−ラ ロシュ アーゲー |
Identification of subjects who can receive anti-angiogenic therapy
|
PT2848625T
(en)
|
2008-08-14 |
2019-10-25 |
Genentech Inc |
Methods for removing a contaminant using indigenous protein displacement ion exchange membrane chromatography
|
JP2012501188A
(en)
*
|
2008-08-29 |
2012-01-19 |
ジェネンテック, インコーポレイテッド |
Diagnostic agents and treatments for VEGF-independent tumors
|
EP2331133A4
(en)
|
2008-09-05 |
2012-09-12 |
Univ Duke |
Anti-lipid antibodies
|
EP2684570A1
(en)
|
2008-09-10 |
2014-01-15 |
F. Hoffmann-La Roche AG |
Compositions and methods for the prevention of oxidative degradation of proteins
|
WO2010037046A1
(en)
|
2008-09-28 |
2010-04-01 |
Fraunhofer Usa, Inc. |
Humanized neuraminidase antibody and methods of use thereof
|
US8268314B2
(en)
|
2008-10-08 |
2012-09-18 |
Hoffmann-La Roche Inc. |
Bispecific anti-VEGF/anti-ANG-2 antibodies
|
JP5913980B2
(en)
|
2008-10-14 |
2016-05-11 |
ジェネンテック, インコーポレイテッド |
Immunoglobulin variants and uses thereof
|
KR101698362B1
(en)
|
2008-11-03 |
2017-01-20 |
몰리큘라 파트너스 아게 |
Binding proteins inhibiting the VEGF-A receptor interaction
|
EP2540843B1
(en)
|
2008-11-05 |
2014-07-02 |
Genentech, Inc. |
Genetic polymorphisms in age-related macular degeneration
|
SI2361085T2
(en)
|
2008-11-22 |
2018-11-30 |
F. Hoffmann-La Roche Ag |
Use of anti-vegf antibody in combination with chemotherapy for treating breast cancer
|
JP2012512244A
(en)
|
2008-12-16 |
2012-05-31 |
イー・エム・デイー・ミリポア・コーポレイシヨン |
Protein purification
|
EP2370561B1
(en)
|
2008-12-16 |
2019-08-07 |
EMD Millipore Corporation |
Stirred tank reactor and method
|
CA2746120A1
(en)
|
2008-12-23 |
2010-07-01 |
Genentech, Inc. |
Methods and compositions for diagnostic use in cancer patients
|
WO2010081173A2
(en)
|
2009-01-12 |
2010-07-15 |
Cytomx Therapeutics, Llc |
Modified antibody compositions, methods of making and using thereof
|
WO2010081838A2
(en)
|
2009-01-14 |
2010-07-22 |
Novartis Ag |
Sterile prefilled container
|
US9186336B2
(en)
|
2009-02-06 |
2015-11-17 |
The General Hospital Corporation |
Methods of treating vascular lesions
|
EP2398494A4
(en)
*
|
2009-02-23 |
2015-10-28 |
Cytomx Therapeutics Inc |
Proproteins and methods of use thereof
|
EP2400992B1
(en)
|
2009-02-27 |
2015-07-22 |
Genentech, Inc. |
Methods and compositions for protein labelling
|
EP2405750B1
(en)
|
2009-03-13 |
2018-05-09 |
Abraxis BioScience, LLC |
Combination therapy with thiocolchicine derivatives
|
BRPI1006270B1
(en)
|
2009-03-25 |
2022-08-16 |
Genentech, Inc |
ANTI-A5SS1 ANTIBODY, IMMUNOCONJUGATE, PHARMACEUTICAL COMPOSITION, IN VITRO OR EX VIVO METHOD TO DETECT A5SS1 PROTEIN, USE OF AN ANTIBODY AND KIT TO DETECT A5SS1 PROTEIN
|
BRPI1014089A2
(en)
|
2009-04-02 |
2016-04-19 |
Roche Glycart Ag |
multispecific antibodies comprising full length antibodies and single chain fab fragments
|
PL2417156T3
(en)
|
2009-04-07 |
2015-07-31 |
Roche Glycart Ag |
Trivalent, bispecific antibodies
|
EP2918602A1
(en)
*
|
2009-04-16 |
2015-09-16 |
AbbVie Biotherapeutics Inc. |
Anti-TNF-alpha antibodies and their uses
|
AU2010239368A1
(en)
*
|
2009-04-20 |
2011-11-10 |
Genentech, Inc. |
Adjuvant cancer therapy
|
ES2708124T3
(en)
|
2009-04-27 |
2019-04-08 |
Oncomed Pharm Inc |
Procedure for preparing heteromultimeric molecules
|
CA2665956A1
(en)
*
|
2009-05-07 |
2010-11-07 |
Samir Patel |
Combination treatment for ocular diseases
|
WO2010129609A2
(en)
|
2009-05-07 |
2010-11-11 |
The Regents Of The University Of California |
Antibodies and methods of use thereof
|
WO2010129917A2
(en)
|
2009-05-08 |
2010-11-11 |
Vaccinex, Inc. |
Anti-cd100 antibodies and methods for using the same
|
US8404811B2
(en)
|
2009-05-08 |
2013-03-26 |
Genentech, Inc. |
Humanized anti-EGFL7 antibodies and methods using same
|
WO2010145846A1
(en)
|
2009-06-15 |
2010-12-23 |
Bayer Bioscience N.V. |
Nicotiana benthamiana plants deficient in xylosyltransferase activity
|
US9676845B2
(en)
|
2009-06-16 |
2017-06-13 |
Hoffmann-La Roche, Inc. |
Bispecific antigen binding proteins
|
US20110076271A1
(en)
|
2009-07-13 |
2011-03-31 |
Genentech, Inc. |
Diagnostic methods and compositions for treatment of cancer
|
AR078060A1
(en)
|
2009-07-14 |
2011-10-12 |
Novartis Ag |
DECONTAMINATION OF CONTAINER SURFACE PREVIOUSLY FILLED IN SECONDARY PACKAGING
|
TW201106972A
(en)
|
2009-07-27 |
2011-03-01 |
Genentech Inc |
Combination treatments
|
SG178177A1
(en)
*
|
2009-07-31 |
2012-03-29 |
Genentech Inc |
Inhibition of tumor metastasis using bv8- or g-csf-antagonists
|
PT2464725T
(en)
|
2009-08-11 |
2020-05-21 |
Hoffmann La Roche |
Production of proteins in glutamine-free cell culture media
|
CA2770321A1
(en)
|
2009-08-14 |
2011-02-17 |
Genentech, Inc. |
Biological markers for monitoring patient response to vegf antagonists
|
WO2011022264A1
(en)
*
|
2009-08-15 |
2011-02-24 |
Genentech, Inc. |
Anti-angiogenesis therapy for the treatment of previously treated breast cancer
|
MX2012002565A
(en)
|
2009-09-01 |
2012-05-29 |
Genentech Inc |
Enhanced protein purification through a modified protein a elution.
|
US8642515B2
(en)
|
2009-09-04 |
2014-02-04 |
University Of Louisville Research Foundation, Inc. |
Genetic determinants of prostate cancer risk
|
CN102597776A
(en)
|
2009-09-11 |
2012-07-18 |
霍夫曼-拉罗奇有限公司 |
Method to identify a patient with an increased likelihood of re sponding to an anti-cancer agent
|
NZ701769A
(en)
|
2009-09-16 |
2016-06-24 |
Genentech Inc |
Coiled coil and/or tether containing protein complexes and uses thereof
|
MX2012002909A
(en)
|
2009-09-17 |
2012-04-19 |
Hoffmann La Roche |
Methods and compositions for diagnostics use in cancer patients.
|
EP2483307A1
(en)
|
2009-09-29 |
2012-08-08 |
Fraunhofer USA, Inc. |
Influenza hemagglutinin antibodies, compositions, and related methods
|
PT2488204E
(en)
|
2009-10-16 |
2016-06-09 |
Oncomed Pharm Inc |
Therapeutic combination and use of dll4 antagonist antibodies and anti-hypertensive agents
|
AU2010310804B2
(en)
|
2009-10-21 |
2013-08-01 |
Genentech, Inc. |
Genetic polymorphisms in age-related macular degeneration
|
WO2011056502A1
(en)
|
2009-10-26 |
2011-05-12 |
Genentech, Inc. |
Bone morphogenetic protein receptor type ii compositions and methods of use
|
WO2011056497A1
(en)
|
2009-10-26 |
2011-05-12 |
Genentech, Inc. |
Activin receptor type iib compositions and methods of use
|
TWI505836B
(en)
|
2009-12-11 |
2015-11-01 |
Genentech Inc |
Anti-vegf-c antibodies and methods using same
|
US8765432B2
(en)
|
2009-12-18 |
2014-07-01 |
Oligasis, Llc |
Targeted drug phosphorylcholine polymer conjugates
|
CN107095846A
(en)
|
2009-12-21 |
2017-08-29 |
霍夫曼-拉罗奇有限公司 |
Antibody formulations
|
HUE027713T2
(en)
|
2009-12-23 |
2016-10-28 |
Hoffmann La Roche |
Anti-bv8 antibodies and uses thereof
|
EP2695889A1
(en)
|
2009-12-29 |
2014-02-12 |
Dr. Reddy's Laboratories Limited |
Protein purification by ion exchange
|
EP2531592A1
(en)
|
2010-02-04 |
2012-12-12 |
Vivalis |
Fed-batch process using concentrated cell culture medium for the efficient production of biologics in eb66 cells
|
RU2012140447A
(en)
*
|
2010-02-23 |
2014-03-27 |
Дженентек, Инк. |
ANTIANGIOGENIC THERAPY FOR TREATMENT OF OVARIAN CANCER
|
CA3027749A1
(en)
|
2010-03-22 |
2011-09-29 |
Junyan Ji |
Compositions and methods useful for stabilizing protein-containing formulations
|
TWI426920B
(en)
|
2010-03-26 |
2014-02-21 |
Hoffmann La Roche |
Bispecific, bivalent anti-vegf/anti-ang-2 antibodies
|
TW201138821A
(en)
|
2010-03-26 |
2011-11-16 |
Roche Glycart Ag |
Bispecific antibodies
|
CN107158389A
(en)
|
2010-03-29 |
2017-09-15 |
阿布拉科斯生物科学有限公司 |
Strengthen the method for medicine delivery and therapeutic agent validity
|
WO2011123395A1
(en)
|
2010-03-29 |
2011-10-06 |
Abraxis Bioscience, Llc |
Methods of treating cancer
|
US20130156755A1
(en)
|
2010-04-19 |
2013-06-20 |
Synta Pharmaceuticals Corp. |
Cancer therapy using a combination of a hsp90 inhibitory compounds and a vegf inhibitor
|
AR081361A1
(en)
|
2010-04-30 |
2012-08-29 |
Molecular Partners Ag |
MODIFIED UNION PROTEINS THAT INHIBIT THE RECEPTOR INTERACTION OF THE VASCULAR ENDOTELIAL GROWTH FACTOR FROM GLICOPROTEIN TO VEGF-A
|
CA2794864A1
(en)
|
2010-05-03 |
2011-11-10 |
Genentech, Inc. |
Compositions and methods useful for reducing the viscosity of protein-containing formulations
|
SG10201804385YA
(en)
|
2010-05-17 |
2018-06-28 |
Emd Millipore Corp |
Stimulus responsive polymers for the purification of biomolecules
|
WO2011150241A2
(en)
|
2010-05-28 |
2011-12-01 |
Genentech, Inc. |
Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase
|
WO2011153224A2
(en)
|
2010-06-02 |
2011-12-08 |
Genentech, Inc. |
Diagnostic methods and compositions for treatment of cancer
|
WO2011153243A2
(en)
|
2010-06-02 |
2011-12-08 |
Genentech, Inc. |
Anti-angiogenesis therapy for treating gastric cancer
|
EP2575804A4
(en)
|
2010-06-04 |
2013-10-23 |
Abraxis Bioscience Llc |
Methods of treatment of pancreatic cancer
|
EP2585045B1
(en)
|
2010-06-24 |
2019-08-21 |
F.Hoffmann-La Roche Ag |
Compositions and methods containing alkylgycosides for stabilizing protein-containing formulations
|
JP2013530242A
(en)
|
2010-07-02 |
2013-07-25 |
ジェネンテック, インコーポレイテッド |
Treatment of angiogenic pigment epithelial detachment using anti-VEGF therapy
|
SG186983A1
(en)
|
2010-07-09 |
2013-02-28 |
Genentech Inc |
Anti-neuropilin antibodies and methods of use
|
JP2013534307A
(en)
|
2010-07-19 |
2013-09-02 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
Methods for identifying patients with increased likelihood of response to anti-cancer therapy
|
WO2012010549A1
(en)
|
2010-07-19 |
2012-01-26 |
F. Hoffmann-La Roche Ag |
Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy
|
CA2807014A1
(en)
|
2010-08-03 |
2012-02-09 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
EP2603525A1
(en)
|
2010-08-13 |
2013-06-19 |
F.Hoffmann-La Roche Ag |
Antibodies to il-1beta and il-18, for treatment of disease
|
TW201208703A
(en)
|
2010-08-17 |
2012-03-01 |
Roche Glycart Ag |
Combination therapy of an afucosylated CD20 antibody with an anti-VEGF antibody
|
EP2609111B1
(en)
|
2010-08-24 |
2017-11-01 |
F. Hoffmann-La Roche AG |
Bispecific antibodies comprising a disulfide stabilized-fv fragment
|
US9046513B2
(en)
|
2010-08-26 |
2015-06-02 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
WO2012030512A1
(en)
|
2010-09-03 |
2012-03-08 |
Percivia Llc. |
Flow-through protein purification process
|
US8551479B2
(en)
|
2010-09-10 |
2013-10-08 |
Oncomed Pharmaceuticals, Inc. |
Methods for treating melanoma
|
BR112013012040A2
(en)
|
2010-11-15 |
2016-08-16 |
Five Prime Therapeutics Inc |
high-dose cancer treatment of soluble fdfr1 fusion proteins
|
SG191153A1
(en)
|
2010-12-23 |
2013-07-31 |
Hoffmann La Roche |
Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
|
JOP20210044A1
(en)
*
|
2010-12-30 |
2017-06-16 |
Takeda Pharmaceuticals Co |
Anti-cd38 antibodies
|
WO2012092539A2
(en)
|
2010-12-31 |
2012-07-05 |
Takeda Pharmaceutical Company Limited |
Antibodies to dll4 and uses thereof
|
WO2012095514A1
(en)
|
2011-01-14 |
2012-07-19 |
Vivalis |
Recombinant protein production system
|
CN103403025B
(en)
|
2011-02-28 |
2016-10-12 |
弗·哈夫曼-拉罗切有限公司 |
Monovalent antigen binding protein
|
JP5764677B2
(en)
|
2011-02-28 |
2015-08-19 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
Antigen binding protein
|
CA2830349C
(en)
|
2011-03-17 |
2019-07-16 |
The University Of Birmingham |
Re-directed immunotherapy
|
MX336740B
(en)
|
2011-03-29 |
2016-01-29 |
Roche Glycart Ag |
Antibody fc variants.
|
US9527925B2
(en)
|
2011-04-01 |
2016-12-27 |
Boehringer Ingelheim International Gmbh |
Bispecific binding molecules binding to VEGF and ANG2
|
US9150549B2
(en)
|
2011-04-01 |
2015-10-06 |
Genentech, Inc. |
Combinations of AKT inhibitor compounds and erlotinib, and methods of use
|
US9932386B2
(en)
|
2011-04-20 |
2018-04-03 |
Acceleron Pharma, Inc. |
Endoglin polypeptides and uses thereof
|
US20140178398A1
(en)
|
2011-05-03 |
2014-06-26 |
Genentech, Inc |
Vascular disruption agents and uses thereof
|
WO2012172054A1
(en)
|
2011-06-16 |
2012-12-20 |
Scil Proteins Gmbh |
Modified multimeric ubiquitin proteins binding vegf-a
|
MX2013014687A
(en)
|
2011-06-30 |
2014-02-17 |
Genentech Inc |
Anti-c-met antibody formulations.
|
WO2013009767A2
(en)
|
2011-07-12 |
2013-01-17 |
Epitomics, Inc. |
Facs-based method for obtaining an antibody sequence
|
US9181532B2
(en)
|
2011-07-29 |
2015-11-10 |
Icon Genetics Gmbh |
Production of galactosylated N-glycans in plants
|
KR20140068877A
(en)
|
2011-08-17 |
2014-06-09 |
제넨테크, 인크. |
Inhibition of angiogenesis in refractory tumors
|
US8858941B2
(en)
|
2011-09-23 |
2014-10-14 |
Oncomed Pharmaceuticals, Inc. |
VEGF/DLL4 binding agents and uses thereof
|
WO2013050155A1
(en)
|
2011-10-04 |
2013-04-11 |
Icon Genetics Gmbh |
Nicotiana benthamiana plants deficient in fucosyltransferase activity
|
BR112014008885B1
(en)
|
2011-10-11 |
2021-02-17 |
Vaccinex, Inc |
use of an isolated antibody or antigen-binding fragment that specifically binds to semaphorin-4d to decrease blood-brain barrier (bbb) permeability in an individual with increased bbb permeability and a neuroinflammatory disorder
|
CN107080843A
(en)
*
|
2011-10-13 |
2017-08-22 |
爱尔皮奥治疗有限公司 |
The treatment of illness in eye
|
CN104039351A
(en)
|
2011-10-13 |
2014-09-10 |
阿尔皮奥治疗学股份有限公司 |
Methods for treating vascular leak syndrome and cancer
|
WO2013082511A1
(en)
|
2011-12-02 |
2013-06-06 |
Genentech, Inc. |
Methods for overcoming tumor resistance to vegf antagonists
|
US9988424B2
(en)
|
2011-12-05 |
2018-06-05 |
Duke University |
Immunogens comprising human immunodeficiency virus V1/V2 polypeptides
|
US8790652B2
(en)
|
2011-12-06 |
2014-07-29 |
Vaccinex, Inc. |
Use of the combination of semaphorin-4D inhibitory molecules and VEGF inhibitory molecules to inhibit angiogenesis
|
IL267585B
(en)
|
2011-12-22 |
2022-09-01 |
Genentech Inc |
Ion exchange membrane chromatography
|
WO2013091903A1
(en)
|
2011-12-22 |
2013-06-27 |
Novo Nordisk A/S |
Anti-crac channel antibodies
|
MX2014008101A
(en)
|
2011-12-30 |
2014-09-25 |
Abbvie Inc |
Dual variable domain immunoglobulins against il-13 and/or il-17.
|
EP2802346B1
(en)
|
2012-01-13 |
2018-09-12 |
F.Hoffmann-La Roche Ag |
Biological markers for identifying patients for treatment with vegf antagonists
|
CA2861124A1
(en)
|
2012-02-10 |
2013-08-15 |
Genentech, Inc. |
Single-chain antibodies and other heteromultimers
|
ES2617853T3
(en)
|
2012-02-27 |
2017-06-20 |
Universitat De Barcelona |
Protease resistant compounds useful as transporters across the blood brain barrier and transporter-load constructs
|
SI2831261T1
(en)
|
2012-03-27 |
2018-01-31 |
F.Hoffmann-La Roche |
Method for producing recombinant proteins with low levels of DHNA (1,4-dihydroxy-2-naphthoate)
|
BR112014024219A8
(en)
|
2012-03-30 |
2017-07-25 |
Genentech Inc |
METHODS FOR DETERMINING, OPTIMIZING THERAPEUTIC EFFECTIVENESS, MONITORING, THERAPY SELECTION AND DISORDER DIAGNOSIS AND KIT
|
PL2838918T3
(en)
|
2012-04-20 |
2019-11-29 |
Merus Nv |
Methods and means for the production of heterodimeric ig-like molecules
|
WO2013170182A1
(en)
|
2012-05-11 |
2013-11-14 |
Synta Pharmaceuticals Corp. |
Treating cancer with an hsp90 inhibitory compound
|
US10494440B2
(en)
|
2012-05-11 |
2019-12-03 |
Vaccinex, Inc. |
Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
|
PL2855528T3
(en)
|
2012-05-31 |
2019-10-31 |
Hoffmann La Roche |
Methods of treating cancer using pd-l1 axis binding antagonists and vegf antagonists
|
ES2895406T3
(en)
|
2012-06-01 |
2022-02-21 |
Novartis Ag |
Syringe
|
JP5933830B2
(en)
|
2012-06-08 |
2016-06-15 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
Variant selectivity and combination of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents for the treatment of cancer
|
WO2014001325A1
(en)
|
2012-06-27 |
2014-01-03 |
F. Hoffmann-La Roche Ag |
Method for making antibody fc-region conjugates comprising at least one binding entity that specifically binds to a target and uses thereof
|
KR20150023889A
(en)
|
2012-06-27 |
2015-03-05 |
에프. 호프만-라 로슈 아게 |
Method for selection and production of tailor-made highly selective and multi-specific targeting entities containing at least two different binding entities and uses thereof
|
JOP20200175A1
(en)
|
2012-07-03 |
2017-06-16 |
Novartis Ag |
Syringe
|
HRP20211641T1
(en)
|
2012-07-13 |
2022-02-04 |
Roche Glycart Ag |
Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases
|
WO2014025813A1
(en)
|
2012-08-07 |
2014-02-13 |
Genentech, Inc. |
Combination therapy for the treatment of glioblastoma
|
PL2898086T3
(en)
|
2012-09-19 |
2019-04-30 |
Hoffmann La Roche |
Methods and compositions for preventing norleucine misincorporation into proteins
|
JP6371294B2
(en)
|
2012-10-31 |
2018-08-08 |
オンコメッド ファーマシューティカルズ インコーポレイテッド |
Methods and monitoring of treatment with DLL4 antagonists
|
RU2636043C2
(en)
|
2012-11-01 |
2017-11-17 |
Эббви Инк. |
Anti-vegf/dll4-immunoglobulins with double variable domains and their application
|
AU2013341711A1
(en)
|
2012-11-12 |
2015-05-21 |
Redwood Bioscience, Inc. |
Compounds and methods for producing a conjugate
|
US9310374B2
(en)
|
2012-11-16 |
2016-04-12 |
Redwood Bioscience, Inc. |
Hydrazinyl-indole compounds and methods for producing a conjugate
|
WO2014078733A1
(en)
|
2012-11-16 |
2014-05-22 |
The Regents Of The University Of California |
Pictet-spengler ligation for protein chemical modification
|
MX2015007931A
(en)
|
2012-12-18 |
2015-10-05 |
Novartis Ag |
Compositions and methods that utilize a peptide tag that binds to hyaluronan.
|
CN104994885B
(en)
|
2012-12-19 |
2017-09-29 |
基因泰克公司 |
Method and composition for radiohalogen protein labeling
|
US9770426B2
(en)
|
2013-01-11 |
2017-09-26 |
Massachusetts Eye And Ear Infirmary |
CYP450 lipid metabolites reduce inflammation and angiogenesis
|
US9682154B2
(en)
|
2013-02-04 |
2017-06-20 |
Vascular Biogenics Ltd. |
Methods of inducing responsiveness to anti-angiogenic agent
|
SG11201505940WA
(en)
|
2013-02-18 |
2015-08-28 |
Vegenics Pty Ltd |
Ligand binding molecules and uses thereof
|
MY189047A
(en)
|
2013-03-13 |
2022-01-21 |
Genentech Inc |
Antibody formulations
|
BR112015023797A2
(en)
|
2013-03-15 |
2017-10-24 |
Abbvie Inc |
dual specificity binding proteins directed against il-1b and / or il-17
|
RU2015144020A
(en)
|
2013-03-15 |
2017-04-21 |
Дженентек, Инк. |
ENVIRONMENTS FOR CULTIVATION OF CELLS AND METHODS FOR PRODUCING ANTIBODIES
|
US9707154B2
(en)
|
2013-04-24 |
2017-07-18 |
Corning Incorporated |
Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
|
PE20151807A1
(en)
|
2013-04-29 |
2015-12-02 |
Hoffmann La Roche |
MODIFIED ANTIBODIES OF BINDING TO HUMAN FCRN AND METHOD OF USE
|
RU2015154985A
(en)
|
2013-05-23 |
2017-06-29 |
Файв Прайм Терапьютикс, Инк. |
CANCER TREATMENT METHODS
|
KR101541478B1
(en)
|
2013-05-31 |
2015-08-05 |
동아쏘시오홀딩스 주식회사 |
Anti-vegf antibodies and pharmaceutical composition comprising same for preventing, diagnosing or treating cancer or angiogenesis-related disease
|
CA3098741A1
(en)
|
2013-06-25 |
2014-12-31 |
Vaccinex, Inc. |
Use of semaphorin-4d inhibitory molecules in combination with an immune modulating therapy to inhibit tumor growth and metastases
|
EA201690212A8
(en)
|
2013-07-12 |
2016-08-31 |
Офтотек Корпорейшн |
METHODS OF TREATMENT OR PREVENTION OF OPHTHALMIC PATHOLOGICAL CONDITIONS
|
AU2014306867B2
(en)
|
2013-08-12 |
2017-10-26 |
Genentech, Inc. |
Compositions and method for treating complement-associated conditions
|
US10456470B2
(en)
|
2013-08-30 |
2019-10-29 |
Genentech, Inc. |
Diagnostic methods and compositions for treatment of glioblastoma
|
US10617755B2
(en)
|
2013-08-30 |
2020-04-14 |
Genentech, Inc. |
Combination therapy for the treatment of glioblastoma
|
JP6463361B2
(en)
|
2013-09-08 |
2019-01-30 |
コディアック サイエンシーズ インコーポレイテッドKodiak Sciences Inc. |
Factor VIII zwitterionic polymer conjugate
|
NZ630881A
(en)
|
2013-10-10 |
2016-03-31 |
Vaccinex Inc |
Use of semaphorin-4d binding molecules for treatment of atherosclerosis
|
CN105612182B
(en)
|
2013-10-11 |
2019-12-10 |
豪夫迈·罗氏有限公司 |
Multispecific domain exchange consensus variable light chain antibodies
|
NZ630892A
(en)
|
2013-10-21 |
2016-03-31 |
Vaccinex Inc |
Use of semaphorin-4d binding molecules for treating neurodegenerative disorders
|
CA2928708A1
(en)
|
2013-10-25 |
2015-04-30 |
Acceleron Pharma, Inc. |
Endoglin peptides to treat fibrotic diseases
|
WO2015071348A1
(en)
|
2013-11-18 |
2015-05-21 |
Formycon Ag |
Pharmaceutical composition of an anti-vegf antibody
|
CN105744935B
(en)
|
2013-11-27 |
2022-09-30 |
雷德伍德生物科技股份有限公司 |
Hydrazino-pyrrolo compounds and methods for forming conjugates
|
US20160130336A1
(en)
*
|
2013-12-31 |
2016-05-12 |
Development Center For Biotechnology |
Anti-vegf antibodies and use thereof
|
CA2932364A1
(en)
|
2014-01-15 |
2015-07-23 |
F. Hoffmann-La Roche Ag |
Fc-region variants with improved protein a-binding
|
JOP20200094A1
(en)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
Antibody molecules to pd-1 and uses thereof
|
JOP20200096A1
(en)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
Antibody molecules to tim-3 and uses thereof
|
CA2939556A1
(en)
|
2014-02-14 |
2015-08-20 |
Andrew S. Chi |
Improved methods for the treatment of vascularizing cancers
|
ES2831014T3
(en)
|
2014-02-18 |
2021-06-07 |
Inst Nat Sante Rech Med |
Methods and pharmaceutical compositions for the treatment of diseases mediated by the signaling pathway of the NRP-1 / OBR complex
|
EP3110941A4
(en)
|
2014-02-25 |
2017-10-18 |
Dr. Reddy's Laboratories Ltd. |
Process for modifying galactosylation and g0f content of a glycoprotein composition by glutamine supplementation
|
ES2784749T3
(en)
|
2014-03-10 |
2020-09-30 |
Richter Gedeon Nyrt |
Immunoglobulin purification with the use of precleaning steps
|
MY187246A
(en)
|
2014-03-14 |
2021-09-14 |
Novartis Ag |
Antibody molecules to lag-3 and uses thereof
|
RU2016141385A
(en)
|
2014-03-24 |
2018-04-28 |
Дженентек, Инк. |
CANCER TREATMENT WITH C-MET ANTAGONISTS AND THEIR CORRELATION WITH HGF EXPRESSION
|
CA2943834A1
(en)
|
2014-03-31 |
2015-10-08 |
Genentech, Inc. |
Combination therapy comprising anti-angiogenesis agents and ox40 binding agonists
|
CN106536561A
(en)
|
2014-05-01 |
2017-03-22 |
豪夫迈·罗氏有限公司 |
Anti-factor D antibody variants and uses thereof
|
EP3828202A1
(en)
|
2014-05-12 |
2021-06-02 |
Formycon AG |
Pre-filled plastic syringe containing a vegf antagonist
|
CN106714839A
(en)
|
2014-05-15 |
2017-05-24 |
百时美施贵宝公司 |
Treatment of lung cancer using a combination of an anti-PD-1 antibody and another anti-cancer agent
|
JP6668260B2
(en)
|
2014-06-06 |
2020-03-18 |
レッドウッド バイオサイエンス, インコーポレイテッド |
Anti-HER2 antibody-maytansine conjugate and method thereof
|
EP3160991A2
(en)
|
2014-06-25 |
2017-05-03 |
Novartis AG |
Compositions and methods for long acting proteins
|
EP3160990A2
(en)
|
2014-06-25 |
2017-05-03 |
Novartis AG |
Compositions and methods for long acting proteins
|
US9840553B2
(en)
|
2014-06-28 |
2017-12-12 |
Kodiak Sciences Inc. |
Dual PDGF/VEGF antagonists
|
NZ727705A
(en)
|
2014-07-09 |
2023-12-22 |
Genentech Inc |
Ph adjustment to improve thaw recovery of cell banks
|
WO2016011052A1
(en)
|
2014-07-14 |
2016-01-21 |
Genentech, Inc. |
Diagnostic methods and compositions for treatment of glioblastoma
|
CA2957717C
(en)
|
2014-08-12 |
2021-10-19 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with il-2 and integrin-binding-fc-fusion protein
|
CN105330739B
(en)
*
|
2014-08-12 |
2020-12-25 |
中美华世通生物医药科技(武汉)有限公司 |
Antibody or antigen binding fragment thereof specifically bound with human vascular endothelial growth factor and application thereof
|
US20170216403A1
(en)
|
2014-08-12 |
2017-08-03 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with il-2, a therapeutic antibody, and an immune checkpoint blocker
|
EP3191127A1
(en)
|
2014-09-13 |
2017-07-19 |
Novartis AG |
Combination therapies of egfr inhibitors
|
KR20170057339A
(en)
|
2014-09-15 |
2017-05-24 |
제넨테크, 인크. |
Antibody formulations
|
BR112017006664A2
(en)
|
2014-10-03 |
2017-12-26 |
Novartis Ag |
combination therapies
|
MA41044A
(en)
|
2014-10-08 |
2017-08-15 |
Novartis Ag |
COMPOSITIONS AND METHODS OF USE FOR INCREASED IMMUNE RESPONSE AND CANCER TREATMENT
|
JP6877339B2
(en)
|
2014-10-14 |
2021-05-26 |
ノバルティス アーゲー |
Antibody molecule against PD-L1 and its use
|
CN107208076A
(en)
|
2014-10-17 |
2017-09-26 |
科达制药 |
Butyrylcholine esterase amphoteric ion polymer conjugate
|
WO2016065329A1
(en)
|
2014-10-24 |
2016-04-28 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods for inducing phagocytosis of mhc class i positive cells and countering anti-cd47/sirpa resistance
|
MX2017005258A
(en)
|
2014-10-31 |
2017-07-26 |
Oncomed Pharm Inc |
Combination therapy for treatment of disease.
|
CA2960297A1
(en)
|
2014-11-10 |
2016-05-19 |
Genentech, Inc. |
Anti-interleukin-33 antibodies and uses thereof
|
EP3227332B1
(en)
|
2014-12-03 |
2019-11-06 |
F.Hoffmann-La Roche Ag |
Multispecific antibodies
|
EP3230316B1
(en)
|
2014-12-11 |
2022-01-05 |
Bayer HealthCare LLC |
Treatment of age related macular degeneration with a small active choroidal neovascularization lesion
|
US10093733B2
(en)
|
2014-12-11 |
2018-10-09 |
Abbvie Inc. |
LRP-8 binding dual variable domain immunoglobulin proteins
|
US20170340733A1
(en)
|
2014-12-19 |
2017-11-30 |
Novartis Ag |
Combination therapies
|
RU2710735C2
(en)
|
2014-12-23 |
2020-01-10 |
Дженентек, Инк. |
Compositions and methods of treating and diagnosing cancer-resistant cancer
|
RU2699544C2
(en)
*
|
2015-01-28 |
2019-09-06 |
Пфайзер Инк. |
Stable aqueous anti-vascular endothelial growth factor (vegf) antibody composition
|
KR20220070057A
(en)
|
2015-03-09 |
2022-05-27 |
인테크린 테라퓨틱스, 아이엔씨. |
Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy
|
PL3286315T3
(en)
|
2015-04-24 |
2021-11-02 |
F. Hoffmann-La Roche Ag |
Methods of identifying bacteria comprising binding polypeptides
|
WO2016191751A1
(en)
|
2015-05-28 |
2016-12-01 |
Bristol-Myers Squibb Company |
Treatment of pd-l1 positive lung cancer using an anti-pd-1 antibody
|
US11078278B2
(en)
|
2015-05-29 |
2021-08-03 |
Bristol-Myers Squibb Company |
Treatment of renal cell carcinoma
|
WO2016200835A1
(en)
|
2015-06-08 |
2016-12-15 |
Genentech, Inc. |
Methods of treating cancer using anti-ox40 antibodies and pd-1 axis binding antagonists
|
TW201710286A
(en)
|
2015-06-15 |
2017-03-16 |
艾伯維有限公司 |
Binding proteins against VEGF, PDGF, and/or their receptors
|
EP3322731B1
(en)
|
2015-07-14 |
2021-01-13 |
Bristol-Myers Squibb Company |
Method of treating cancer using immune checkpoint inhibitor; antibody that binds to programmed death-1 receptor (pd-1) or programmed death ligand 1 (pd-l1)
|
EP3878465A1
(en)
|
2015-07-29 |
2021-09-15 |
Novartis AG |
Combination therapies comprising antibody molecules to tim-3
|
EP3964528A1
(en)
|
2015-07-29 |
2022-03-09 |
Novartis AG |
Combination therapies comprising antibody molecules to lag-3
|
EP3792279A3
(en)
|
2015-07-29 |
2021-07-07 |
Allergan, Inc. |
Heavy chain only antibodies to ang-2
|
HU231463B1
(en)
|
2015-08-04 |
2024-01-28 |
Richter Gedeon Nyrt. |
Method for increasing the galactose content of recombinant proteins
|
JP2018523673A
(en)
|
2015-08-14 |
2018-08-23 |
アラーガン、インコーポレイテッドAllergan,Incorporated |
Heavy chain only antibody against PDGF
|
CA2987644A1
(en)
*
|
2015-08-21 |
2017-03-02 |
Immunomedics, Inc. |
Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
|
MA42844A
(en)
|
2015-09-17 |
2018-07-25 |
Immunogen Inc |
THERAPEUTIC COMBINATIONS INCLUDING ANTI-FOLR1 IMMUNOCONJUGATES
|
WO2017046140A1
(en)
|
2015-09-18 |
2017-03-23 |
Bayer Pharma Aktiengesellschaft |
Treatment regimens for dr and rvo in dependence of the extent of retinal ischemia
|
ES2940360T3
(en)
|
2015-09-22 |
2023-05-05 |
Inst Nat Sante Rech Med |
Polypeptides capable of inhibiting the binding between leptin and neuropilin-1
|
JP6967003B2
(en)
|
2015-09-23 |
2021-11-17 |
メレオ バイオファーマ 5 インコーポレイテッド |
Methods and compositions for the treatment of cancer
|
CN116987187A
(en)
|
2015-09-23 |
2023-11-03 |
豪夫迈·罗氏有限公司 |
Optimized variants of anti-VEGF antibodies
|
WO2017055322A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of neutrophils in a tissue sample
|
WO2017055320A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of cytotoxic lymphocytes in a tissue sample
|
WO2017055319A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of b cells in a tissue sample
|
WO2017055324A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of cells of monocytic origin in a tissue sample
|
WO2017055327A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of endothelial cells in a tissue sample
|
WO2017055325A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of nk cells in a tissue sample
|
WO2017055321A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of fibroblasts in a tissue sample
|
WO2017055326A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of myeloid dendritic cells in a tissue sample
|
EP3362095B1
(en)
|
2015-10-13 |
2020-11-25 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for the treatment of choroidal neovascularisation
|
EP3368074A2
(en)
|
2015-10-30 |
2018-09-05 |
Hoffmann-La Roche AG |
Anti-factor d antibodies and conjugates
|
CN108472382A
(en)
|
2015-10-30 |
2018-08-31 |
豪夫迈·罗氏有限公司 |
Anti- factor D antibody variants conjugate and application thereof
|
CA3001362C
(en)
|
2015-10-30 |
2020-10-13 |
Genentech, Inc. |
Anti-htra1 antibodies and methods of use thereof
|
CA3003647A1
(en)
|
2015-10-30 |
2017-05-04 |
Genentech, Inc. |
Anti-factor d antibody formulations
|
KR20180072821A
(en)
|
2015-11-03 |
2018-06-29 |
얀센 바이오테크 인코포레이티드 |
Antibodies that specifically bind to PD-1 and uses thereof
|
WO2017079419A1
(en)
|
2015-11-05 |
2017-05-11 |
The Regents Of The University Of California |
Cells labelled with lipid conjugates and methods of use thereof
|
MX2018006092A
(en)
|
2015-11-18 |
2019-01-31 |
Formycon Ag |
Pre-filled pharmaceutical package comprising a liquid formulation of a vegf-antagonist.
|
KR20180083377A
(en)
|
2015-11-18 |
2018-07-20 |
포르미콘 아게 |
Pre-filled plastic syringe containing VEGF antagonist
|
KR20180105123A
(en)
|
2015-11-18 |
2018-09-27 |
에스아이오2 메디컬 프로덕츠, 인크. |
Pharmaceutical package for ophthalmic preparations
|
PT3384049T
(en)
|
2015-12-03 |
2023-08-18 |
Regeneron Pharma |
Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-vegf
|
MX2018007423A
(en)
|
2015-12-17 |
2018-11-09 |
Novartis Ag |
Antibody molecules to pd-1 and uses thereof.
|
US11066465B2
(en)
|
2015-12-30 |
2021-07-20 |
Kodiak Sciences Inc. |
Antibodies and conjugates thereof
|
CA3011638C
(en)
|
2016-01-26 |
2023-01-10 |
Formycon Ag |
Liquid formulation of a vegf antagonist
|
CN109069638B
(en)
|
2016-03-24 |
2022-03-29 |
璟尚生物制药公司 |
Trispecific inhibitors for cancer therapy
|
EP3436610A1
(en)
|
2016-03-29 |
2019-02-06 |
Geltor, Inc. |
Expression of proteins in gram-negative bacteria wherein the ratio of periplasmic volume to cytoplasmic volume is between 0.5:1 and 10:1
|
CA3019921A1
(en)
|
2016-04-15 |
2017-10-19 |
Genentech, Inc. |
Methods for monitoring and treating cancer
|
JP2019515670A
(en)
|
2016-04-15 |
2019-06-13 |
ジェネンテック, インコーポレイテッド |
Methods for monitoring and treating cancer
|
CN115350263A
(en)
|
2016-05-20 |
2022-11-18 |
拜尔哈文制药股份有限公司 |
Use of glutamate modulators and immunotherapy for the treatment of cancer
|
JP7050702B2
(en)
|
2016-07-08 |
2022-04-08 |
ジェネンテック, インコーポレイテッド |
Methods for diagnosing and treating cancer based on the expression status and mutation status of NRF2 and its downstream target gene
|
JP2019524706A
(en)
|
2016-07-08 |
2019-09-05 |
ジェネンテック, インコーポレイテッド |
Use of human epididymis protein 4 (HE4) to assess responsiveness of MUC16 positive cancer treatment
|
WO2018011166A2
(en)
|
2016-07-12 |
2018-01-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of myeloid dendritic cells in a tissue sample
|
BR112019001206A2
(en)
|
2016-07-20 |
2019-06-25 |
Aerpio Therapeutics Inc |
humanized monoclonal antibodies targeting ve-ptp (hptp-ss)
|
CN106222129A
(en)
*
|
2016-07-29 |
2016-12-14 |
广东东阳光药业有限公司 |
A kind of cell culture medium improving antibody purity and cultural method
|
WO2018018613A1
(en)
|
2016-07-29 |
2018-02-01 |
广东东阳光药业有限公司 |
Cell culture medium and culture method for increasing purity of antibody
|
KR20190038829A
(en)
|
2016-08-12 |
2019-04-09 |
제넨테크, 인크. |
Combination therapy with MEK inhibitor, PD-1 axis inhibitor, and VEGF inhibitor
|
KR102538827B1
(en)
*
|
2016-08-23 |
2023-05-31 |
메디뮨 리미티드 |
Anti-VEF-A Antibodies and Uses Thereof
|
WO2018070390A1
(en)
|
2016-10-12 |
2018-04-19 |
第一三共株式会社 |
Composition containing anti-robo4 antibody and other agents
|
EP3528785A4
(en)
|
2016-10-19 |
2020-12-02 |
Adverum Biotechnologies, Inc. |
Modified aav capsids and uses thereof
|
US10537637B2
(en)
|
2017-01-05 |
2020-01-21 |
Gensun Biopharma Inc. |
Checkpoint regulator antagonists
|
CA3049656A1
(en)
|
2017-01-10 |
2018-07-19 |
Nodus Therapeutics |
Combination tumor treatment with an integrin-binding-fc fusion protein and immune modulator
|
US10350266B2
(en)
|
2017-01-10 |
2019-07-16 |
Nodus Therapeutics, Inc. |
Method of treating cancer with a multiple integrin binding Fc fusion protein
|
MX2019010295A
(en)
|
2017-03-01 |
2019-11-21 |
Genentech Inc |
Diagnostic and therapeutic methods for cancer.
|
CN110582510B
(en)
*
|
2017-03-24 |
2023-09-15 |
科学与工业研究委员会 |
Method for purifying recombinant antibody fragments
|
MX2019011867A
(en)
|
2017-04-03 |
2020-01-09 |
Coherus Biosciences Inc |
Pparî³ agonist for treatment of progressive supranuclear palsy.
|
JOP20190245A1
(en)
|
2017-04-20 |
2019-10-15 |
Novartis Ag |
Sustained release delivery systems comprising traceless linkers
|
MX2019013750A
(en)
|
2017-05-19 |
2020-07-20 |
Council Scient Ind Res |
A method for producing refolded recombinant humanized ranibizumab.
|
WO2018215580A1
(en)
|
2017-05-24 |
2018-11-29 |
Formycon Ag |
Method for sterilizing prefilled plastic syringes containing a vegf antagonist
|
EP3630043A1
(en)
|
2017-05-24 |
2020-04-08 |
Formycon AG |
Sterilizable pre-filled pharmaceutical packages comprising a liquid formulation of a vegf-antagonist
|
US20200171244A1
(en)
|
2017-05-24 |
2020-06-04 |
Sio2 Medical Products, Inc. |
Sterilizable pharmaceutical package for ophthalmic formulations
|
TW201904610A
(en)
|
2017-06-14 |
2019-02-01 |
德商拜耳製藥公司 |
Non-antibody vegf antagonists for the treatment of neovascular glaucoma
|
US11312783B2
(en)
|
2017-06-22 |
2022-04-26 |
Novartis Ag |
Antibody molecules to CD73 and uses thereof
|
US20200172628A1
(en)
|
2017-06-22 |
2020-06-04 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
EP3650045A4
(en)
|
2017-07-04 |
2021-07-07 |
Daiichi Sankyo Company, Limited |
Drug for retinal degenerative disease associated with photoreceptor degeneration
|
WO2019020777A1
(en)
|
2017-07-26 |
2019-01-31 |
Formycon Ag |
Liquid formulation of a vegf antagonist
|
WO2019057946A1
(en)
|
2017-09-25 |
2019-03-28 |
F. Hoffmann-La Roche Ag |
Multi-cyclic aromatic compounds as factor d inhibitors
|
US11180541B2
(en)
|
2017-09-28 |
2021-11-23 |
Geltor, Inc. |
Recombinant collagen and elastin molecules and uses thereof
|
WO2019077593A1
(en)
|
2017-10-20 |
2019-04-25 |
Vascular Biogenics Ltd. |
Diagnostic methods for anti-angiogenic agent therapy
|
JP2021506861A
(en)
|
2017-12-19 |
2021-02-22 |
アコーオス インコーポレイテッド |
AAV-mediated delivery of therapeutic antibodies to the inner ear
|
CN111479588A
(en)
|
2017-12-29 |
2020-07-31 |
豪夫迈·罗氏有限公司 |
Methods for improving VEGF receptor blocking selectivity of anti-VEGF antibodies
|
CN110003328B
(en)
*
|
2018-01-05 |
2022-04-19 |
百奥泰生物制药股份有限公司 |
Long-acting low-toxicity recombinant anti-VEGF humanized monoclonal antibody and production method thereof
|
JP7005772B2
(en)
|
2018-02-06 |
2022-02-10 |
エフ.ホフマン-ラ ロシュ アーゲー |
Treatment of ophthalmic diseases
|
AR114275A1
(en)
|
2018-03-09 |
2020-08-12 |
Agenus Inc |
ANTI-CD73 ANTIBODIES AND METHODS OF USING THEM
|
CA3097067A1
(en)
|
2018-04-16 |
2019-10-24 |
Onquality Pharmaceuticals China Ltd. |
Method for preventing or treating side effects of cancer therapy
|
CA3099551A1
(en)
|
2018-05-10 |
2019-11-14 |
Regeneron Pharmaceuticals, Inc. |
High concentration vegf receptor fusion protein containing formulations
|
SG11202011633SA
(en)
|
2018-05-24 |
2020-12-30 |
Janssen Biotech Inc |
Psma binding agents and uses thereof
|
US11519020B2
(en)
|
2018-05-25 |
2022-12-06 |
Regeneron Pharmaceuticals, Inc. |
Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF
|
UY38247A
(en)
|
2018-05-30 |
2019-12-31 |
Novartis Ag |
ANTIBODIES AGAINST ENTPD2, COMBINATION THERAPIES AND METHODS OF USE OF ANTIBODIES AND COMBINATION THERAPIES
|
WO2019232244A2
(en)
|
2018-05-31 |
2019-12-05 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
WO2019229116A1
(en)
|
2018-05-31 |
2019-12-05 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Intravitreal delivery of a decorin polypeptide for the treatment of choroidal neovascularisation
|
US10597453B2
(en)
|
2018-06-29 |
2020-03-24 |
Gensun Biopharma, Inc. |
Antitumor immune checkpoint regulator antagonists
|
US20210253996A1
(en)
|
2018-07-03 |
2021-08-19 |
Bristol-Myers Squibb Company |
Methods of producing recombinant proteins
|
GB201811410D0
(en)
|
2018-07-12 |
2018-08-29 |
F Star Beta Ltd |
OX40 Binding molecules
|
CN109053895B
(en)
|
2018-08-30 |
2020-06-09 |
中山康方生物医药有限公司 |
Bifunctional antibody for resisting PD-1-VEGFA, pharmaceutical composition and application thereof
|
CN113164597A
(en)
|
2018-09-24 |
2021-07-23 |
爱尔皮奥制药公司 |
Multispecific antibodies targeting HPTP-beta (VE-PTP) and VEGF
|
KR20210074341A
(en)
|
2018-10-10 |
2021-06-21 |
베링거 인겔하임 인터내셔날 게엠베하 |
Methods for membrane gas transfer in high-density bioreactor cultures
|
KR20210079311A
(en)
|
2018-10-18 |
2021-06-29 |
제넨테크, 인크. |
Diagnosis and treatment methods for sarcoma renal cancer
|
HUP1800376A2
(en)
|
2018-11-07 |
2020-05-28 |
Richter Gedeon Nyrt |
Method for modifying the glycosylation profile of a recombinant glycoprotein produced in cell culture
|
WO2020109343A1
(en)
|
2018-11-29 |
2020-06-04 |
F. Hoffmann-La Roche Ag |
Combination therapy for treatment of macular degeneration
|
CN109134651B
(en)
*
|
2018-12-03 |
2019-02-22 |
上海复宏汉霖生物技术股份有限公司 |
A kind of monoclonal antibody of anti-vegf and its preparation method and application
|
US20200207812A1
(en)
|
2018-12-07 |
2020-07-02 |
Coherus Biosciences, Inc. |
Methods for producing recombinant proteins
|
CN113226472A
(en)
|
2018-12-17 |
2021-08-06 |
雷维托普有限公司 |
Dual immune cell adaptor
|
KR20210139329A
(en)
|
2019-03-13 |
2021-11-22 |
바스큘라 바이오제닉스 리미티드 |
Methods of anti-tumor therapy
|
CA3133652A1
(en)
|
2019-04-01 |
2020-10-08 |
Genentech, Inc. |
Compositions and methods for stabilizing protein-containing formulations
|
HUP1900112A1
(en)
|
2019-04-04 |
2020-10-28 |
Richter Gedeon Nyrt |
Improvement of affinity chromatography of immunoglobulins by using pre-capture flocculation
|
KR20210151930A
(en)
|
2019-04-12 |
2021-12-14 |
젤터, 인코포레이티드 |
Recombinant elastin and preparation thereof
|
EP3956022A1
(en)
|
2019-04-19 |
2022-02-23 |
Janssen Biotech, Inc. |
Methods of treating prostate cancer with an anti- psma/cd3 antibody
|
TW202106699A
(en)
|
2019-04-26 |
2021-02-16 |
美商愛德維仁生物科技公司 |
Variant aav capsids for intravitreal delivery
|
AU2020270376A1
(en)
|
2019-05-03 |
2021-10-07 |
Genentech, Inc. |
Methods of treating cancer with an anti-PD-L1 antibody
|
EP3965816A1
(en)
|
2019-05-06 |
2022-03-16 |
MedImmune Limited |
Combination of monalizumab, durvalumab, chemotherapy and bevacizumab or cetuximab for the treatment of colorectal cancer
|
EP3990116A1
(en)
|
2019-06-28 |
2022-05-04 |
Gensun Biopharma Inc. |
ANTITUMOR ANTAGONIST CONSISTING OF A MUTATED TGFß1 - RII EXTRACELLULAR DOMAIN AND AN IMMUNOGLOBULIN SCAFFOLD
|
US20220315887A1
(en)
|
2019-08-01 |
2022-10-06 |
Bristol-Myers Squibb Company |
Methods of improving protein productivity in fed-batch cell cultures
|
JP2022548881A
(en)
|
2019-09-18 |
2022-11-22 |
ノバルティス アーゲー |
ENTPD2 Antibodies, Combination Therapy and Methods of Using Antibodies and Combination Therapy
|
AU2020364071A1
(en)
|
2019-10-10 |
2022-05-26 |
Kodiak Sciences Inc. |
Methods of treating an eye disorder
|
WO2021072210A1
(en)
|
2019-10-11 |
2021-04-15 |
Coherus Biosciences, Inc. |
Methods of purifying ranibizumab or a ranibizumab variant
|
WO2021072182A1
(en)
|
2019-10-11 |
2021-04-15 |
Coherus Biosciences, Inc. |
Methods for producing ranibizumab
|
JP2023510464A
(en)
|
2019-11-19 |
2023-03-14 |
プロタリクス リミテッド |
Removal of constructs from transformed cells
|
BR112022010069A2
(en)
|
2019-11-25 |
2022-09-06 |
Akeso Biopharma Inc |
BIESPECIFIC ANTIBODY, ISOLATED NUCLEIC ACID MOLECULE, VECTOR, HOST CELL, CONJUGATE, KIT, USE OF BIESPECIFIC ANTIBODY AND PHARMACEUTICAL COMPOSITION
|
WO2021180818A1
(en)
|
2020-03-11 |
2021-09-16 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods of determining whether a subject has or is at risk of having a central serous chorioretinopathy
|
IL296256A
(en)
|
2020-03-13 |
2022-11-01 |
Genentech Inc |
Anti-interleukin-33 antibodies and uses thereof
|
WO2021202959A1
(en)
|
2020-04-03 |
2021-10-07 |
Genentech, Inc. |
Therapeutic and diagnostic methods for cancer
|
EP4171617A1
(en)
|
2020-06-30 |
2023-05-03 |
Mendus B.V. |
Use of leukemia-derived cells in ovarian cancer vaccines
|
UY39324A
(en)
|
2020-07-16 |
2022-02-25 |
Novartis Ag |
ANTI-BETACELLULIN ANTIBODIES, THEIR FRAGMENTS, MULTISPECIFIC BINDING MOLECULES, EXPRESSION CASSETTES, COMPOSITIONS AND TREATMENT METHODS.
|
WO2022066595A1
(en)
|
2020-09-22 |
2022-03-31 |
Bristol-Myers Squibb Company |
Methods for producing therapeutic proteins
|
KR20230113283A
(en)
|
2020-10-05 |
2023-07-28 |
프로탈릭스 리미티드 |
Dicer-Like Knockout Plant Cells
|
AU2021360935A1
(en)
|
2020-10-15 |
2023-05-25 |
F. Hoffmann-La Roche Ag |
Hyaluronic acid binding derivatives of versican (vg1) for long acting delivery of therapeutics
|
JP2023550028A
(en)
|
2020-11-13 |
2023-11-30 |
ジェネンテック, インコーポレイテッド |
Methods and compositions comprising KRASG12C inhibitors and VEGF inhibitors for treating solid tumors
|
AU2021391433A1
(en)
|
2020-12-01 |
2023-06-22 |
Akouos, Inc. |
Anti-vegf antibody constructs and related methods for treating vestibular schwannoma associated symptoms
|
KR20230135075A
(en)
|
2021-01-22 |
2023-09-22 |
멘두스 비.브이. |
Tumor Vaccination Method
|
KR20230137393A
(en)
|
2021-01-28 |
2023-10-04 |
얀센 바이오테크 인코포레이티드 |
PSMA binding protein and its uses
|
EP4304633A1
(en)
|
2021-03-12 |
2024-01-17 |
Mendus B.V. |
Methods of vaccination and use of cd47 blockade
|
IL305805A
(en)
|
2021-03-12 |
2023-11-01 |
Akeso Biopharma Inc |
Pharmaceutical combination containing anti-pd-1-anti-vegfa bispecific antibody, and use thereof
|
EP4330436A1
(en)
|
2021-04-30 |
2024-03-06 |
Genentech, Inc. |
Therapeutic and diagnostic methods and compositions for cancer
|
BR112023024375A2
(en)
|
2021-05-28 |
2024-02-15 |
Shanghai Regenelead Therapies Co Ltd |
RECOMBINANT ADENO-ASSOCIATED VIRUS HAVING VARIANT CAPSID AND ITS APPLICATION
|
US20220389120A1
(en)
|
2021-06-03 |
2022-12-08 |
Gensun Biopharma Inc. |
Multispecific antagonists
|
AU2022302170A1
(en)
|
2021-07-02 |
2023-12-21 |
F. Hoffmann-La Roche Ag |
Methods and compositions for treating cancer
|
WO2023010095A1
(en)
|
2021-07-28 |
2023-02-02 |
F. Hoffmann-La Roche Ag |
Methods and compositions for treating cancer
|
WO2023015234A1
(en)
|
2021-08-05 |
2023-02-09 |
Bristol-Myers Squibb Company |
Cell culture methods for producing therapeutic proteins
|
AU2022327397A1
(en)
|
2021-08-13 |
2024-03-14 |
Innovent Biologics (Suzhou) Co., Ltd. |
Anti-vegf a and -vegf c bispecific antibody and use thereof
|
EP4145456A1
(en)
|
2021-09-06 |
2023-03-08 |
Bayer AG |
Prediction of a change related to a macular fluid
|
WO2023049687A1
(en)
|
2021-09-21 |
2023-03-30 |
Bristol-Myers Squibb Company |
Methods of controlling the level of dissolved oxygen (do) in a solution comprising a recombinant protein in a storage container
|
WO2023080900A1
(en)
|
2021-11-05 |
2023-05-11 |
Genentech, Inc. |
Methods and compositions for classifying and treating kidney cancer
|
WO2023150142A1
(en)
|
2022-02-02 |
2023-08-10 |
Akouos, Inc. |
Anti-vegf antibody constructs and related methods for treating vestibular schwannoma associated symptoms
|
WO2024040175A1
(en)
|
2022-08-18 |
2024-02-22 |
Pulmatrix Operating Company, Inc. |
Methods for treating cancer using inhaled angiogenesis inhibitor
|
WO2024051223A1
(en)
|
2022-09-09 |
2024-03-14 |
中山康方生物医药有限公司 |
Pharmaceutical composition and use thereof
|