CA2293266A1 - Treating metal surfaces to enhance bio-compatibility and/or physical characteristics - Google Patents

Treating metal surfaces to enhance bio-compatibility and/or physical characteristics Download PDF

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Publication number
CA2293266A1
CA2293266A1 CA002293266A CA2293266A CA2293266A1 CA 2293266 A1 CA2293266 A1 CA 2293266A1 CA 002293266 A CA002293266 A CA 002293266A CA 2293266 A CA2293266 A CA 2293266A CA 2293266 A1 CA2293266 A1 CA 2293266A1
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CA
Canada
Prior art keywords
compatibility
bio
molecules
metal surfaces
heparin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002293266A
Other languages
French (fr)
Other versions
CA2293266C (en
Inventor
Kadem Gayad Al-Lamee
Yousef Samih Taktak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Covestro Deutschland AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2293266A1 publication Critical patent/CA2293266A1/en
Application granted granted Critical
Publication of CA2293266C publication Critical patent/CA2293266C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0041—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate characterised by the choice of an antithrombatic agent other than heparin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F28—HEAT EXCHANGE IN GENERAL
    • F28F—DETAILS OF HEAT-EXCHANGE AND HEAT-TRANSFER APPARATUS, OF GENERAL APPLICATION
    • F28F13/00—Arrangements for modifying heat-transfer, e.g. increasing, decreasing
    • F28F13/18—Arrangements for modifying heat-transfer, e.g. increasing, decreasing by applying coatings, e.g. radiation-absorbing, radiation-reflecting; by surface treatment, e.g. polishing

Abstract

A metal, glass or ceramics surface is treated to enhance its compatibility with biological material such as blood or blood related products. Treatment involves covalently bonding to the surface by means of a catalyst functional molecules, each of which has at least one alkoxysilane group which can form at least one first covalent bond by reaction with the oxide or hydroxide of said surface and at least one other group which can participate in free-radical polymerisation. Free-radical polymerisation from said functional molecules in then effected to build bio-compatible and/or hydrophilic polymer chains. The compatibility of the metal surface with biological material may be further improved by bonding bio-active molecules, such as heparin or heparin-derived molecules to the polymer chains. Suitable metal surfaces are those of medical devices such as heat exchangers, coronary and peripheral stents and guide wires used in angioplasty.
CA002293266A 1997-06-03 1998-06-03 Treating metal surfaces to enhance bio-compatibility and/or physical characteristics Expired - Fee Related CA2293266C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9711377A GB2325934A (en) 1997-06-03 1997-06-03 Treating metal surfaces to enhance bio-compatibility and/or physical characteristics
GB9711377.3 1997-06-03
PCT/GB1998/001609 WO1998055162A2 (en) 1997-06-03 1998-06-03 Treating metal surfaces to enhance bio-compatibility

Publications (2)

Publication Number Publication Date
CA2293266A1 true CA2293266A1 (en) 1998-12-10
CA2293266C CA2293266C (en) 2008-08-12

Family

ID=10813448

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002293266A Expired - Fee Related CA2293266C (en) 1997-06-03 1998-06-03 Treating metal surfaces to enhance bio-compatibility and/or physical characteristics

Country Status (10)

Country Link
US (1) US6599558B1 (en)
EP (1) EP0988071B1 (en)
JP (1) JP4357005B2 (en)
AT (1) ATE233110T1 (en)
AU (1) AU740161B2 (en)
CA (1) CA2293266C (en)
DE (1) DE69811666T2 (en)
ES (1) ES2191309T3 (en)
GB (1) GB2325934A (en)
WO (1) WO1998055162A2 (en)

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Also Published As

Publication number Publication date
JP4357005B2 (en) 2009-11-04
GB9711377D0 (en) 1997-07-30
EP0988071A2 (en) 2000-03-29
JP2002502286A (en) 2002-01-22
ATE233110T1 (en) 2003-03-15
WO1998055162A2 (en) 1998-12-10
AU7778998A (en) 1998-12-21
US6599558B1 (en) 2003-07-29
CA2293266C (en) 2008-08-12
GB2325934A (en) 1998-12-09
DE69811666D1 (en) 2003-04-03
ES2191309T3 (en) 2003-09-01
DE69811666T2 (en) 2003-12-18
EP0988071B1 (en) 2003-02-26
WO1998055162A3 (en) 1999-03-04
AU740161B2 (en) 2001-11-01

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