CA2298414A1 - Method for preventing and treating hearing loss using a neurturin protein product - Google Patents

Method for preventing and treating hearing loss using a neurturin protein product Download PDF

Info

Publication number
CA2298414A1
CA2298414A1 CA002298414A CA2298414A CA2298414A1 CA 2298414 A1 CA2298414 A1 CA 2298414A1 CA 002298414 A CA002298414 A CA 002298414A CA 2298414 A CA2298414 A CA 2298414A CA 2298414 A1 CA2298414 A1 CA 2298414A1
Authority
CA
Canada
Prior art keywords
preventing
protein product
hearing loss
treating hearing
neurturin protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002298414A
Other languages
French (fr)
Other versions
CA2298414C (en
Inventor
Ella Magal
John M. Delaney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc.
Ella Magal
John M. Delaney
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc., Ella Magal, John M. Delaney filed Critical Amgen Inc.
Publication of CA2298414A1 publication Critical patent/CA2298414A1/en
Application granted granted Critical
Publication of CA2298414C publication Critical patent/CA2298414C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators

Abstract

The present invention relates generally to methods for preventing and/or treating injury or degeneration of cochlear hair cells and spiral ganglion neurons by administering a neurturin neurotrophic factor protein product. The invention relates more specifically to methods for treating sensorineural hearing loss.
CA002298414A 1997-07-30 1998-07-17 Method for preventing and treating hearing loss using a neurturin protein product Expired - Fee Related CA2298414C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5418497P 1997-07-30 1997-07-30
US60/054,184 1997-07-30
US09/106,486 US6043221A (en) 1997-07-30 1998-06-29 Method for preventing and treating hearing loss using a neuturin protein product
US09/106,486 1998-06-29
PCT/US1998/014600 WO1999006064A1 (en) 1997-07-30 1998-07-17 Method for preventing and treating hearing loss using a neurturin protein product

Publications (2)

Publication Number Publication Date
CA2298414A1 true CA2298414A1 (en) 1999-02-11
CA2298414C CA2298414C (en) 2004-09-28

Family

ID=26732740

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002298414A Expired - Fee Related CA2298414C (en) 1997-07-30 1998-07-17 Method for preventing and treating hearing loss using a neurturin protein product

Country Status (10)

Country Link
US (2) US6043221A (en)
EP (1) EP1005358B1 (en)
JP (1) JP2001525316A (en)
AT (1) ATE230607T1 (en)
AU (1) AU8658298A (en)
CA (1) CA2298414C (en)
DE (1) DE69810635T2 (en)
DK (1) DK1005358T3 (en)
ES (1) ES2190093T3 (en)
WO (1) WO1999006064A1 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6043221A (en) * 1997-07-30 2000-03-28 Amgen Inc. Method for preventing and treating hearing loss using a neuturin protein product
DE19807426A1 (en) * 1998-02-23 1999-10-14 Otogene Biotechnologische Fors Procedure for the treatment of diseases or disorders of the inner ear
US6423321B2 (en) 1999-02-24 2002-07-23 Edward L. Tobinick Cytokine antagonists for the treatment of sensorineural hearing loss
US7053200B1 (en) 1999-06-01 2006-05-30 Baylor College Of Medicine Compositions and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis, and abnormal cell proliferation
WO2000073764A2 (en) 1999-06-01 2000-12-07 Baylor College Of Medicine Composition and methods for the therapeutic use of an atonal-associated sequence
DE10025152A1 (en) * 2000-05-23 2001-12-06 Marlies Knipper Treatment of noise- or age-induced hearing deficiency, comprises using neurotrophin stimulating agents to counteract cochlear neurodegeneration
US20050222070A1 (en) 2002-05-29 2005-10-06 Develogen Aktiengesellschaft Fuer Entwicklungsbiologische Forschung Pancreas-specific proteins
US20050171579A1 (en) * 2001-11-09 2005-08-04 Claudia Tasche Stimulating device
AUPR879201A0 (en) * 2001-11-09 2001-12-06 Cochlear Limited Subthreshold stimulation of a cochlea
US20100030130A1 (en) * 2001-11-09 2010-02-04 Cochlear Limited Pharmaceutical intervention for modulation of neural plasticity
US20100030301A1 (en) * 2001-11-09 2010-02-04 Cochlear Limited Electrical stimulation for modulation of neural plasticity
AU2003208900A1 (en) * 2002-01-30 2003-09-02 House Ear Institute L-carnitine for treatment of hearing loss
AU2003238178A1 (en) 2002-05-29 2003-12-12 Develogen Aktiengesellschaft Fur Entwicklungsbiologische Forschung Pancreas-specific proteins
CN100335502C (en) * 2002-06-27 2007-09-05 学校法人日本医科大学 Method of detecting perilymphatic fistula
AU2003259846A1 (en) * 2002-08-16 2004-03-03 The General Hospital Corporation Non-invasive functional imaging of peripheral nervous system activation in humans and animals
US7390482B2 (en) 2002-10-02 2008-06-24 Anges Mg, Inc. Drug for auditory dysfunction
EP1631259A4 (en) 2002-12-18 2006-08-02 Hough Ear Inst Otologic nanotechnology
US8651113B2 (en) * 2003-06-18 2014-02-18 Swr&D Inc. Magnetically responsive nanoparticle therapeutic constructs and methods of making and using
US7723311B2 (en) * 2003-06-18 2010-05-25 Nanobiomagnetics, Inc. Delivery of bioactive substances to target cells
DE602004021847D1 (en) 2003-11-27 2009-08-13 Develogen Ag METHOD FOR THE PREVENTION AND TREATMENT OF DIABETES WITH NEURTURINE
US20050222127A1 (en) * 2004-03-30 2005-10-06 Alcon, Inc. Use of Rho kinase inhibitors in the treatment of hearing loss, tinnitus and improving body balance
KR20070027621A (en) * 2004-06-08 2007-03-09 알자 코포레이션 Preparation of macromolecular conjugates by four-component condensation reaction
EP1765459B1 (en) 2004-06-15 2018-11-28 Cochlear Limited Automatic determination of the threshold of an evoked neural response
TW200719884A (en) * 2005-03-10 2007-06-01 3M Innovative Properties Co Methods of treating ear infections
US8309057B2 (en) * 2005-06-10 2012-11-13 The Invention Science Fund I, Llc Methods for elevating neurotrophic agents
WO2007030743A2 (en) 2005-09-08 2007-03-15 Massachusetts Eye & Ear Infirmary Cochlear implants containing biological cells and uses thereof
EP1872790A1 (en) 2006-06-26 2008-01-02 DeveloGen Aktiengesellschaft New formulation for increasing bioavailability of neurturin
CN104288775A (en) * 2007-11-05 2015-01-21 伊沃泰克国际有限公司 Novel neurturin conjugates for pharmaceutical use
KR20190026056A (en) 2008-04-21 2019-03-12 오토노미, 인코포레이티드 Auris formulations for treating otic diseases and conditions
AU2010313456A1 (en) * 2009-10-30 2012-05-17 Ntf Therapeutics, Inc. Improved neurturin molecules
US20110195439A1 (en) * 2010-02-10 2011-08-11 Selinfreund Richard H Systems and methods for determining cardiac conditions
WO2015191950A1 (en) * 2014-06-12 2015-12-17 Orbis Biosciences, Inc. Extended-release drug delivery compositions
TWI710635B (en) 2014-10-09 2020-11-21 美商珍維克公司 Adenoviral vector encoding human atonal homolog-1 (hath1)
WO2020045980A1 (en) * 2018-08-28 2020-03-05 Industry-Academic Cooperation Foundation, Yonsei University Pharmaceutical composition for treating or preventing sensorineural hearing loss
CN110124014A (en) * 2019-05-16 2019-08-16 杭州师范大学 Recombinant human nerve enation factor Neuritin albumen application and it is a kind of for treating the drug of Auditory Neuropathy

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518584A (en) * 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
US5106627A (en) * 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
JP2989002B2 (en) * 1988-12-22 1999-12-13 キリン―アムジエン・インコーポレーテツド Chemically modified granulocyte colony stimulating factor
WO1991010470A1 (en) * 1990-01-08 1991-07-25 Brown University Research Foundation Devices and methods for enhanced delivery of active factors
EP0610254B1 (en) * 1991-09-20 2004-09-01 Amgen Inc. Glial derived neurotrophic factor
ATE218893T1 (en) * 1993-08-12 2002-06-15 Neurotech Sa BIOCOMPATIBLE IMMUNOISOLATION CAPSULES CONTAINING GENETICALLY MODIFIED CELLS
FR2717824B1 (en) * 1994-03-25 1996-04-26 Rhone Poulenc Rorer Sa Recombinant viruses, preparation and use in gene therapy.
US5658785A (en) * 1994-06-06 1997-08-19 Children's Hospital, Inc. Adeno-associated virus materials and methods
US5739307A (en) * 1995-08-28 1998-04-14 Washington University Polynucleotide encoding neurturin neurotrophic factor
AU1121997A (en) * 1995-11-29 1997-06-19 Amgen, Inc. Method for treating sensory neuropathy using glial cell line-derived neurotrophic factor (gdnf) protein product
US5929041A (en) * 1996-02-23 1999-07-27 Amgen Inc. Method for preventing and treating sensorineural hearing loss and vestibular disorders using glial cell line-derived neurotrophic factor(GDNF) protein product
US6043221A (en) * 1997-07-30 2000-03-28 Amgen Inc. Method for preventing and treating hearing loss using a neuturin protein product

Also Published As

Publication number Publication date
JP2001525316A (en) 2001-12-11
ATE230607T1 (en) 2003-01-15
EP1005358B1 (en) 2003-01-08
DE69810635T2 (en) 2003-05-28
CA2298414C (en) 2004-09-28
AU8658298A (en) 1999-02-22
DK1005358T3 (en) 2003-02-24
DE69810635D1 (en) 2003-02-13
US6043221A (en) 2000-03-28
US6274554B1 (en) 2001-08-14
EP1005358A1 (en) 2000-06-07
WO1999006064A1 (en) 1999-02-11
ES2190093T3 (en) 2003-07-16

Similar Documents

Publication Publication Date Title
CA2298414A1 (en) Method for preventing and treating hearing loss using a neurturin protein product
CA2217565A1 (en) Method for preventing and treating sensorineural hearing loss and vestibular disorders using glial cell line-derived neurotrophic factor (gdnf) protein product
AU1505788A (en) A method and a composition for treating neurological diseases such as migraine, by influencing the nerve cells
AU6775196A (en) Multi-electrode cochlear implant
CA2236158A1 (en) Method for treating retinal ganglion cell injury using glial cell line-derived neurotrophic factor (gdnf) protein product
ITTO930721A0 (en) IMPLANTABLE ELECTRODE, FOR EXAMPLE FOR PACEMAKERS, DEFIBRILLATORS AND SIMILAR.
AU4565096A (en) An implantable atrial defibrillator having ischemia coordinated intervention therapy and method
CA2154424A1 (en) 1-phenyl-3-dimethylaminopropane compounds having a pharmaceutical effect
CA2272584A1 (en) Novel substituted pyrazole derivatives for the treatment of cardiocirculatory diseases
AU2455695A (en) Amino acid amide derivative, process for producing the same,agrohorticultural fungicide, and fungicidal method
AU2746897A (en) Techniques for treating epilepsy by brain stimulation and drug infusion
CA2186260A1 (en) Composition comprising morphine, polypyrrolidone and a polyalkyleneoxide
HK1040053A1 (en) Use of fused pyrrolocarbazoles for preventing/treating damage to sensory hair cells and cochlear neurons
IE791235L (en) Acyl-derivatives of carnitine.
AU2825295A (en) Method for the treatment, prevention or minimization of hair loss
CA2347863A1 (en) Treatment of disorders of the outer retina
AU6241096A (en) A cosmetic antimycotic composition for skin applications and pharmaceutical composition for the treatment of tumorous cells, bladder or nerve disorders
AU1867297A (en) Gene-therapeutic nucleic acid construct, production of same and use of same in the treatment of heart disorders
EP1304119A3 (en) Method for preventing and treating hearing loss using a neurturin protein product
AU1032699A (en) Concentrate of natural antioxidant dietetic fiber from grape, and preparat ion process
CA2353527A1 (en) Use of neurotrophic factor stimulators for the treatment of ophthalmic neurodegenerative diseases
AU5251999A (en) Method of reducing retinal ganglion cell degeneration
AU692030B2 (en) Hydantoin derivatives, process for producing the same and herbicides comprising the same as active ingredients
WO1994025012A3 (en) Medicaments for treatment of migraine, epilepsy and feeding disorders
ZA969139B (en) Pure 3R-3'R stereoisomer of zeaxanthin for treating macular degeneration in humans.

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed