CA2303447A1 - Cationic polymers as toxin-binding agents - Google Patents

Cationic polymers as toxin-binding agents Download PDF

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Publication number
CA2303447A1
CA2303447A1 CA002303447A CA2303447A CA2303447A1 CA 2303447 A1 CA2303447 A1 CA 2303447A1 CA 002303447 A CA002303447 A CA 002303447A CA 2303447 A CA2303447 A CA 2303447A CA 2303447 A1 CA2303447 A1 CA 2303447A1
Authority
CA
Canada
Prior art keywords
toxin
polymer
binding agents
cationic polymers
mammal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002303447A
Other languages
French (fr)
Other versions
CA2303447C (en
Inventor
W. Harry Mandeville Iii
Thomas X. Neenan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Geltex Pharmaceuticals, Inc.
W. Harry Mandeville Iii
Thomas X. Neenan
Genzyme Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geltex Pharmaceuticals, Inc., W. Harry Mandeville Iii, Thomas X. Neenan, Genzyme Corporation filed Critical Geltex Pharmaceuticals, Inc.
Publication of CA2303447A1 publication Critical patent/CA2303447A1/en
Application granted granted Critical
Publication of CA2303447C publication Critical patent/CA2303447C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

A method for treating pathogenic toxins in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising a cationic group attached to the polymer backbone. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.
CA002303447A 1997-09-19 1998-09-08 Cationic polymers as toxin-binding agents Expired - Lifetime CA2303447C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/934,495 US6007803A (en) 1997-09-19 1997-09-19 Ionic polymers as toxin binding agents
US08/934,495 1997-09-19
PCT/US1998/018881 WO1999015186A1 (en) 1997-09-19 1998-09-08 Cationic polymers as toxin-binding agents

Publications (2)

Publication Number Publication Date
CA2303447A1 true CA2303447A1 (en) 1999-04-01
CA2303447C CA2303447C (en) 2008-02-12

Family

ID=25465647

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002303447A Expired - Lifetime CA2303447C (en) 1997-09-19 1998-09-08 Cationic polymers as toxin-binding agents

Country Status (12)

Country Link
US (1) US6007803A (en)
EP (1) EP1014999B1 (en)
JP (1) JP4326143B2 (en)
CN (1) CN1270524A (en)
AT (1) ATE284219T1 (en)
AU (1) AU729205B2 (en)
CA (1) CA2303447C (en)
DE (1) DE69828067T2 (en)
ES (1) ES2235364T3 (en)
NZ (1) NZ503384A (en)
WO (1) WO1999015186A1 (en)
ZA (1) ZA988278B (en)

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AUPO104396A0 (en) 1996-07-17 1996-08-08 Biomolecular Research Institute Limited Antiviral linear polymers
US6290947B1 (en) 1997-09-19 2001-09-18 Geltex Pharmaceuticals, Inc. Ionic polymers as toxin-binding agents
US6290946B1 (en) * 1999-05-13 2001-09-18 Geltex Pharmaceuticals, Inc. Anionic polymers as toxin binders and antibacterial agents
US6482402B1 (en) 1999-05-13 2002-11-19 Geltex Pharmaceuticals, Inc. Antimicrobial compositions and methods
US6270755B1 (en) * 1999-05-13 2001-08-07 Geltex Pharmaceuticals, Inc. Anionic polymers as toxin binders
EP1800687A3 (en) * 1999-05-13 2009-12-30 Genzyme Corporation Anionic polymers as toxin binders and antibacterial agents
WO2001072344A1 (en) * 2000-03-28 2001-10-04 Triple R Holding, Inc. Decontamination of surfaces exposed to biological warfare agents
CA2314494A1 (en) 2000-05-02 2001-11-02 Geltex Pharmaceuticals, Inc. Anionic polymers as species specific antibacterial agents
US6969752B1 (en) * 2000-07-21 2005-11-29 Georgia Tech Research Corporation Water soluble/dispersible and easy removable cationic adhesives and coating for paper recycling
WO2002056895A2 (en) * 2001-01-18 2002-07-25 Genzyme Corporation Ionene polymers and their use in treating mucositis
US20030032352A1 (en) * 2001-03-22 2003-02-13 Yihua Chang Water-dispersible, cationic polymers, a method of making same and items using same
US7070854B2 (en) * 2001-03-22 2006-07-04 Kimberly-Clark Worldwide, Inc. Water-dispersible, cationic polymers, a method of making same and items using same
AU2002257147B9 (en) * 2001-04-18 2005-08-18 Genzyme Corporation Methods of treating syndrome X with aliphatic polyamines
US7763663B2 (en) * 2001-12-19 2010-07-27 University Of Massachusetts Polysaccharide-containing block copolymer particles and uses thereof
CN100411625C (en) * 2002-07-22 2008-08-20 基酶有限公司 Poly(potassium and sodium styrene sulfonate), its manufacture and its uses
WO2004046109A2 (en) * 2002-11-19 2004-06-03 Genzyme Corporation Ionene oligomers and polymers
US20030165403A1 (en) * 2003-03-12 2003-09-04 Marsden James L. Decontamination of surface exposed to biological warfare agents
US20050106267A1 (en) 2003-10-20 2005-05-19 Framework Therapeutics, Llc Zeolite molecular sieves for the removal of toxins
US7459502B2 (en) * 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
US7335795B2 (en) * 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7385012B2 (en) * 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
US7767768B2 (en) * 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7608674B2 (en) * 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7449605B2 (en) * 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
US20060078534A1 (en) * 2004-10-13 2006-04-13 Dominique Charmot Toxin binding compositions
US8088400B2 (en) * 2005-08-22 2012-01-03 Quick-Med Technologies, Inc. Disinfectant with quarternary ammonium polymer and copolymers
US7807766B2 (en) * 2005-09-21 2010-10-05 Cognis Ip Management Gmbh Polymers for use in cleaning compositions
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
US8163886B2 (en) 2006-12-21 2012-04-24 Emd Millipore Corporation Purification of proteins
US8569464B2 (en) 2006-12-21 2013-10-29 Emd Millipore Corporation Purification of proteins
WO2010074953A1 (en) 2008-12-16 2010-07-01 Millipore Corporation Stirred tank reactor and method
US8691918B2 (en) * 2010-05-17 2014-04-08 Emd Millipore Corporation Stimulus responsive polymers for the purification of biomolecules
BR112014005221A2 (en) * 2011-09-08 2017-03-28 Safe Bt Inc use of modified hollow fiber materials for the removal of escherichia coli exotoxins from liquids, preferably from blood and plasma, as well as their use for the treatment of concomitant diseases
JP6709799B2 (en) 2015-03-24 2020-06-17 スリーエム イノベイティブ プロパティズ カンパニー Method for purifying biological composition and article therefor
DE102016205950A1 (en) 2016-04-08 2017-10-12 Dietrich Seidel Means for use in inflammatory conditions of the mucous membranes
CN110198703A (en) 2016-11-21 2019-09-03 艾里奥治疗公司 The transdermal delivery of big reagent
US10428020B2 (en) * 2017-06-16 2019-10-01 The Boeing Company Antimicrobial compounds and nanostructures

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US4026945A (en) * 1974-10-03 1977-05-31 Millmaster Onyx Corporation Anti-microbial quaternary ammonium co-polymers
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Also Published As

Publication number Publication date
DE69828067T2 (en) 2005-12-01
EP1014999A1 (en) 2000-07-05
US6007803A (en) 1999-12-28
AU729205B2 (en) 2001-01-25
CN1270524A (en) 2000-10-18
JP4326143B2 (en) 2009-09-02
WO1999015186A8 (en) 1999-07-01
NZ503384A (en) 2002-03-01
AU9383798A (en) 1999-04-12
WO1999015186A1 (en) 1999-04-01
EP1014999B1 (en) 2004-12-08
CA2303447C (en) 2008-02-12
ATE284219T1 (en) 2004-12-15
ZA988278B (en) 1999-03-23
ES2235364T3 (en) 2005-07-01
JP2001517632A (en) 2001-10-09
DE69828067D1 (en) 2005-01-13

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Effective date: 20180910