CA2321554A1 - System and method for multiple site biphasic stimulation to revert ventricular arrhythmias - Google Patents

System and method for multiple site biphasic stimulation to revert ventricular arrhythmias Download PDF

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Publication number
CA2321554A1
CA2321554A1 CA002321554A CA2321554A CA2321554A1 CA 2321554 A1 CA2321554 A1 CA 2321554A1 CA 002321554 A CA002321554 A CA 002321554A CA 2321554 A CA2321554 A CA 2321554A CA 2321554 A1 CA2321554 A1 CA 2321554A1
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CA
Canada
Prior art keywords
phase
biphasic stimulation
reentry
anodal
stimulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002321554A
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French (fr)
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CA2321554C (en
Inventor
Morton M. Mower
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MR3 Medical LLC
Original Assignee
Morton M. Mower
Mr3 Medical Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morton M. Mower, Mr3 Medical Llc filed Critical Morton M. Mower
Publication of CA2321554A1 publication Critical patent/CA2321554A1/en
Application granted granted Critical
Publication of CA2321554C publication Critical patent/CA2321554C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
    • A61N1/368—Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/3621—Heart stimulators for treating or preventing abnormally high heart rate
    • A61N1/3622—Heart stimulators for treating or preventing abnormally high heart rate comprising two or more electrodes co-operating with different heart regions

Abstract

An anti-reentry apparatus and method for reverting ventricular arrhythmias. Biphasic stimulation is applied at multiple ventricular sites to revert arrhythmias caused by reentry, particularly multiple random reentry. In the preferred embodiment, the first phase of biphasic stimulation is anodal, and is at a maximum subthreshold amplitude. The anodal phase preconditions the myocardium to accept the second phase (cathodal) such that less electrical energy is required to reach the threshold amplitude to produce depolarization. The anodal phase stimulation may have a shape over time that is square wave, ramped, or a series of short square wave pulses. Multiple electrodes located at multiple ventricular sites may be stimulated simultaneously, or they may be sequentially stimulated over time in a manner mimicking the normal progress pattern of cardiac depolarization. The multiple ventricular electrodes may stimulate from internal or external surfaces. One or both ventricles may receive biphasic stimulation from multiple electrodes. The invention also may be practiced with respect to atria.
CA002321554A 1998-03-05 1999-03-04 System and method for multiple site biphasic stimulation to revert ventricular arrhythmias Expired - Fee Related CA2321554C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/035,455 1998-03-05
US09/035,455 US6067470A (en) 1998-03-05 1998-03-05 System and method for multiple site biphasic stimulation to revert ventricular arrhythmias
PCT/US1999/004695 WO1999044682A1 (en) 1998-03-05 1999-03-04 System and method for multiple site biphasic stimulation to revert ventricular arrhythmias

Publications (2)

Publication Number Publication Date
CA2321554A1 true CA2321554A1 (en) 1999-09-10
CA2321554C CA2321554C (en) 2004-05-25

Family

ID=21882785

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002321554A Expired - Fee Related CA2321554C (en) 1998-03-05 1999-03-04 System and method for multiple site biphasic stimulation to revert ventricular arrhythmias

Country Status (24)

Country Link
US (1) US6067470A (en)
EP (1) EP1059963B1 (en)
JP (1) JP3631437B2 (en)
KR (1) KR100436167B1 (en)
CN (1) CN1208102C (en)
AT (1) ATE300974T1 (en)
AU (1) AU749615B2 (en)
BR (1) BR9908465A (en)
CA (1) CA2321554C (en)
CZ (1) CZ20003217A3 (en)
DE (2) DE1059963T1 (en)
DK (1) DK1059963T3 (en)
EA (1) EA003873B1 (en)
ES (1) ES2156102T3 (en)
GE (1) GEP20033083B (en)
HU (1) HUP0100849A3 (en)
ID (1) ID25850A (en)
IL (1) IL138152A0 (en)
NO (1) NO20004394D0 (en)
NZ (1) NZ506533A (en)
PL (1) PL191329B1 (en)
SK (1) SK285745B6 (en)
TR (1) TR200002525T2 (en)
WO (1) WO1999044682A1 (en)

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Also Published As

Publication number Publication date
DE1059963T1 (en) 2001-09-06
NO20004394L (en) 2000-09-04
EA200000906A1 (en) 2001-10-22
AU749615B2 (en) 2002-06-27
CN1208102C (en) 2005-06-29
CN1291903A (en) 2001-04-18
CZ20003217A3 (en) 2004-03-17
NO20004394D0 (en) 2000-09-04
BR9908465A (en) 2000-11-14
WO1999044682A1 (en) 1999-09-10
AU2981499A (en) 1999-09-20
DE69926486T2 (en) 2006-04-13
US6067470A (en) 2000-05-23
JP3631437B2 (en) 2005-03-23
ES2156102T3 (en) 2006-01-16
ID25850A (en) 2000-11-09
KR100436167B1 (en) 2004-06-16
GEP20033083B (en) 2003-10-27
KR20010041649A (en) 2001-05-25
EA003873B1 (en) 2003-10-30
NZ506533A (en) 2003-04-29
ATE300974T1 (en) 2005-08-15
ES2156102T1 (en) 2001-06-16
HUP0100849A2 (en) 2001-06-28
EP1059963A1 (en) 2000-12-20
TR200002525T2 (en) 2000-11-21
SK13212000A3 (en) 2001-02-12
HUP0100849A3 (en) 2004-03-29
PL342657A1 (en) 2001-07-02
DK1059963T3 (en) 2005-09-19
CA2321554C (en) 2004-05-25
EP1059963B1 (en) 2005-08-03
SK285745B6 (en) 2007-07-06
DE69926486D1 (en) 2005-09-08
PL191329B1 (en) 2006-04-28
IL138152A0 (en) 2001-10-31
JP2003517327A (en) 2003-05-27

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