CA2323726A1 - Control of gene expression - Google Patents

Control of gene expression Download PDF

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Publication number
CA2323726A1
CA2323726A1 CA002323726A CA2323726A CA2323726A1 CA 2323726 A1 CA2323726 A1 CA 2323726A1 CA 002323726 A CA002323726 A CA 002323726A CA 2323726 A CA2323726 A CA 2323726A CA 2323726 A1 CA2323726 A1 CA 2323726A1
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Prior art keywords
expression
organism
gene expression
organ
gene
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CA002323726A
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French (fr)
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CA2323726C (en
Inventor
Michael Wayne Graham
Robert Norman Rice
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Commonwealth Scientific and Industrial Research Organization CSIRO
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Individual
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Priority claimed from AUPP2499A external-priority patent/AUPP249998A0/en
Priority claimed from AUPP2492A external-priority patent/AUPP249298A0/en
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Priority to CA002487328A priority Critical patent/CA2487328A1/en
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron

Abstract

The present invention relates generally to a method of modifying gene expression and to synthetic genes for modifying endogenous gene expression in a cell tissue or organ of a transgenic organism, in particular a transgenic animal or plant. More particularly, the present invention utilises recombinant DNA technology to post-transcriptionally modify or modulate the expression of a target gene in a cell, tissue, organ or whole organism, thereby producing novel phenotypes. Novel synthetic genes and genetic constructs which are capable or repressing delaying or otherwise reducing the expression of an endogenous gene or a target gene in an organism when introduced thereto are also provided.
CA002323726A 1998-03-20 1999-03-19 Control of gene expression Expired - Lifetime CA2323726C (en)

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AUPP2499 1998-03-20
AUPP2499A AUPP249998A0 (en) 1998-03-20 1998-03-20 Gene expression I
AUPP2492 1998-03-20
AUPP2492A AUPP249298A0 (en) 1998-03-20 1998-03-20 Synthetic genes and genetic constructs comprising same I
PCT/AU1999/000195 WO1999049029A1 (en) 1998-03-20 1999-03-19 Control of gene expression

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