CA2327127A1 - Improved test strip for the assay of an analyte in a liquid sample - Google Patents

Improved test strip for the assay of an analyte in a liquid sample Download PDF

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Publication number
CA2327127A1
CA2327127A1 CA002327127A CA2327127A CA2327127A1 CA 2327127 A1 CA2327127 A1 CA 2327127A1 CA 002327127 A CA002327127 A CA 002327127A CA 2327127 A CA2327127 A CA 2327127A CA 2327127 A1 CA2327127 A1 CA 2327127A1
Authority
CA
Canada
Prior art keywords
test strip
test
infrared dye
infrared
strip
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002327127A
Other languages
French (fr)
Other versions
CA2327127C (en
Inventor
Paul F. Corey
Michael J. Pugia
Gary E. Rehm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Inc
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23852543&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2327127(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Corp filed Critical Bayer Corp
Publication of CA2327127A1 publication Critical patent/CA2327127A1/en
Application granted granted Critical
Publication of CA2327127C publication Critical patent/CA2327127C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/521—Single-layer analytical elements
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/17—Nitrogen containing
    • Y10T436/173076—Nitrite or nitrate

Abstract

An improved test strip for determining the presence or concentration of unknown or a constituent in a liquid test sample is disclosed. The test strip comprises a support strip and a test pad, wherein the test pad includes a carrier matrix incorporating a reagent composition capable of interacting with the constituent of interest to produce a detectable or measurable response. The test strip further comprises an in-frared dye, applied either to the support strip or incorpo-rated into a test pad, which ensures proper alignment of the test strip in an apparatus having a detection system for the detectable or measurable response. The improved test strip reduces the number of erroneous assays for the constituent of interest.

Claims (15)

1. A test strip for determining the presence or concentra-tion of one or more predetermined analytes in a liquid test sample comprising:
(a) a support handle;
(b) one or more test pads positioned on the support han-dle, each test pad comprising (i) a carrier matrix incorporating (ii) a reagent composition capable of interacting with a predetermined analyte to provide a detectable response; and (c) an infrared dye positioned at a predetermined loca-tion on the test strip.
2. The test strip of Claim 1 wherein about 0.05 to about 0.3 micrograms of the infrared dye are positioned on the test strip.
3. The test strip of Claim 1 wherein the infrared dye is po-sitioned on the support handle of the test strip.
4. The test strip of Claim 1 wherein the infrared dye is in-corporated into one or more test pad.
5. The test strip of Claim 1 wherein the infrared dye is in-corporated into one or more test pad and positioned on the support handle of the test strip.
6. The test strip of Claim 1 wherein the infrared dye ab-sorbs infrared radiation at least at one infrared wavelength.
7. The test strip of Claim 6 wherein the infrared dye lacks a visible color.
8. The test strip of Claim 1 wherein the infrared dye is se-lected from the group consisting of 5,5'-dichloro-11-diphenylamino-3,3'-diethyl-10,12-ethylenethiatricarbocyanine perchlorate, 3-(5-carboxypentyl)-2-[2-[3[[3- (5-carboxypentyl)-1,3-dihydro-1,1-dimethyl-2H-benz[e]indol-2-ylidene]-ethyl-idene]-2-(2-sulfoethylthio)-1-cyclohexene-1-yl]ethenyl]1,1-dimethyl-1H-benz[e]indolinium, 3-(5-carboxypentyl)-2-[2-[3-[[3-(5-carboxypentyl-1,3-dihydro-1,1-dimethyl-2H-benz[e]indol-2-ylidene]-ethylidene]-2-(n-hexylthio)-1-cyclohexen-1-yl]-ethenyl]-1,1-dimethyl-1H-benz[e]indolium, copper (II) 5,9,14, 18,23,27,32,36-octabutoxy-2,3-naphthalocyanine, 5,9,14,18,23, 27,32,36-octabutoxy-2,3-naphthalocyanine, and mixtures thereof.
9. The test strip of Claim 1 wherein the infrared dye is in-corporated into a test pad capable of assaying for nitrite or for occult blood.
10. The test strip of Claim 1 wherein the infrared dye is ap-plied to the support handle and is positioned adjacent to a test pad capable of assaying for nitrite.
11. A method of monitoring alignment of a test strip in an optical pathway of a detection apparatus comprising:
(a) providing a test strip, said test strip comprising (i) a support handle;
(ii) one or more test pads positioned on the support handle, each test pad comprising (i) a carrier matrix incorporating (ii) a reagent composition capable of interacting with a predetermined analyte to provide a detectable response; and (iii) an infrared dye positioned at a predetermined location on the test strip;
(b) inserting the test strip in the detection apparatus;
(c) illuminating the predetermined location of the in-frared dye on the test strip with infrared radia-tion;

(d) measuring a reflectance of infrared radiation from the predetermined location on the test strip; and (e) correlating the reflectance measurement to the alignment of the test strip in the detection appara-tus.
12. The method of Claim 11 wherein the detection apparatus is a scanning-type apparatus.
13. The method of Claim 11 wherein the detection apparatus is a camera-type apparatus.
14. The method of Claim 11 wherein the test strip is rejected by the detection apparatus when misaligned by about 0.05 inch or greater.
15. The method of Claim 11 wherein misalignment of the test strip in the detection apparatus by an amount of 0.030 inch or greater is detected.
CA2327127A 1999-12-17 2000-11-30 Improved test strip for the assay of an analyte in a liquid sample Expired - Lifetime CA2327127C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/466,637 US6316264B1 (en) 1999-12-17 1999-12-17 Test strip for the assay of an analyte in a liquid sample
US09/466,637 1999-12-17

Publications (2)

Publication Number Publication Date
CA2327127A1 true CA2327127A1 (en) 2001-06-17
CA2327127C CA2327127C (en) 2010-08-17

Family

ID=23852543

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2327127A Expired - Lifetime CA2327127C (en) 1999-12-17 2000-11-30 Improved test strip for the assay of an analyte in a liquid sample

Country Status (9)

Country Link
US (1) US6316264B1 (en)
EP (1) EP1111386B2 (en)
JP (2) JP4571300B2 (en)
AT (1) ATE290693T1 (en)
AU (1) AU778320B2 (en)
CA (1) CA2327127C (en)
DE (1) DE60018537T3 (en)
DK (1) DK1111386T4 (en)
ES (1) ES2238244T3 (en)

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Also Published As

Publication number Publication date
DK1111386T4 (en) 2015-01-05
EP1111386B1 (en) 2005-03-09
AU7212300A (en) 2001-06-21
JP4571300B2 (en) 2010-10-27
EP1111386B2 (en) 2014-09-17
ATE290693T1 (en) 2005-03-15
CA2327127C (en) 2010-08-17
EP1111386A2 (en) 2001-06-27
US6316264B1 (en) 2001-11-13
AU778320B2 (en) 2004-11-25
DE60018537T2 (en) 2006-02-23
DK1111386T3 (en) 2005-05-30
ES2238244T3 (en) 2005-09-01
JP2010160164A (en) 2010-07-22
DE60018537D1 (en) 2005-04-14
DE60018537T3 (en) 2015-02-12
JP2001194368A (en) 2001-07-19
EP1111386A3 (en) 2002-12-18

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