CA2327325A1 - Stimulus sensitive gel with radioisotope and methods of making - Google Patents

Stimulus sensitive gel with radioisotope and methods of making Download PDF

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Publication number
CA2327325A1
CA2327325A1 CA002327325A CA2327325A CA2327325A1 CA 2327325 A1 CA2327325 A1 CA 2327325A1 CA 002327325 A CA002327325 A CA 002327325A CA 2327325 A CA2327325 A CA 2327325A CA 2327325 A1 CA2327325 A1 CA 2327325A1
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CA
Canada
Prior art keywords
stimulus
gelling
copolymer
sensitive
radioisotope
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002327325A
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French (fr)
Other versions
CA2327325C (en
Inventor
Richard E. Weller
Michael A. Lind
Darrell R. Fisher
Anna Gutowska
Allison A. Campbell
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Battelle Memorial Institute Inc
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2327325A1 publication Critical patent/CA2327325A1/en
Application granted granted Critical
Publication of CA2327325C publication Critical patent/CA2327325C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1213—Semi-solid forms, gels, hydrogels, ointments, fats and waxes that are solid at room temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The present invention is a thermally reversible stimulus-sensitive gel or gelling copolymer radioisotope carrier that is a linear random copolymer of a [meth-]acrylamide derivative and a hydrophilic comonomer, wherein the linear random copolymer is in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff. Addition of a biodegradable backbone and/or a therapeutic agent imparts further utility. The method of the present invention for making a thermally reversible stimulus-sensitive gelling copolymer radionuclide carrier has the steps of: (a) mixing a stimulus-sensitive reversible gelling copolymer with an aqueous solvent as a stimulus-sensitive reversible gelling solution; and (b) mixing a radioisotope with said stimulus-sensitive reversible gelling solution as said radioisotope carrier. The gel is enhanced by either combining it with a biodegradable backbone and/or a therapeutic agent in a gelling solution made by mixing the copolymer with an aqueous solvent.
CA002327325A 1998-04-10 1999-04-06 Stimulus sensitive gel with radioisotope and methods of making Expired - Lifetime CA2327325C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/058,712 1998-04-10
US09/058,712 US6296831B1 (en) 1998-04-10 1998-04-10 Stimulus sensitive gel with radioisotope and methods of making
PCT/US1999/007662 WO1999055386A2 (en) 1998-04-10 1999-04-06 Stimulus sensitive gel with radioisotope and methods of making

Publications (2)

Publication Number Publication Date
CA2327325A1 true CA2327325A1 (en) 1999-11-04
CA2327325C CA2327325C (en) 2006-01-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA002327325A Expired - Lifetime CA2327325C (en) 1998-04-10 1999-04-06 Stimulus sensitive gel with radioisotope and methods of making

Country Status (9)

Country Link
US (2) US6296831B1 (en)
EP (1) EP1069919B1 (en)
JP (1) JP2002512987A (en)
AT (1) ATE297224T1 (en)
AU (1) AU752477B2 (en)
CA (1) CA2327325C (en)
DE (1) DE69925722T2 (en)
NZ (1) NZ507174A (en)
WO (1) WO1999055386A2 (en)

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US10385115B2 (en) 2015-03-26 2019-08-20 Duke University Fibronectin type III domain-based fusion proteins
US10392611B2 (en) 2013-05-30 2019-08-27 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US11135301B2 (en) 2016-09-14 2021-10-05 Duke University Triblock polypeptide-based nanoparticles for the delivery of hydrophilic drugs
US11155584B2 (en) 2016-09-23 2021-10-26 Duke University Unstructured non-repetitive polypeptides having LCST behavior
US11458205B2 (en) 2015-08-04 2022-10-04 Duke University Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same
US11467156B2 (en) 2016-06-01 2022-10-11 Duke University Nonfouling biosensors
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
US11554097B2 (en) 2017-05-15 2023-01-17 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
US11648200B2 (en) 2017-01-12 2023-05-16 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
US11649275B2 (en) 2018-08-02 2023-05-16 Duke University Dual agonist fusion proteins
US11680083B2 (en) 2017-06-30 2023-06-20 Duke University Order and disorder as a design principle for stimuli-responsive biopolymer networks
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity

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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10392611B2 (en) 2013-05-30 2019-08-27 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US10364451B2 (en) 2013-05-30 2019-07-30 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US10385115B2 (en) 2015-03-26 2019-08-20 Duke University Fibronectin type III domain-based fusion proteins
US11458205B2 (en) 2015-08-04 2022-10-04 Duke University Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
US11467156B2 (en) 2016-06-01 2022-10-11 Duke University Nonfouling biosensors
US11135301B2 (en) 2016-09-14 2021-10-05 Duke University Triblock polypeptide-based nanoparticles for the delivery of hydrophilic drugs
US11155584B2 (en) 2016-09-23 2021-10-26 Duke University Unstructured non-repetitive polypeptides having LCST behavior
US11648200B2 (en) 2017-01-12 2023-05-16 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
US11554097B2 (en) 2017-05-15 2023-01-17 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
US11680083B2 (en) 2017-06-30 2023-06-20 Duke University Order and disorder as a design principle for stimuli-responsive biopolymer networks
US11649275B2 (en) 2018-08-02 2023-05-16 Duke University Dual agonist fusion proteins
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
US11965164B2 (en) 2019-07-12 2024-04-23 Duke University Amphiphilic polynucleotides

Also Published As

Publication number Publication date
WO1999055386A3 (en) 2000-06-29
US6869588B2 (en) 2005-03-22
US20010024636A1 (en) 2001-09-27
EP1069919A2 (en) 2001-01-24
NZ507174A (en) 2003-11-28
AU5311899A (en) 1999-11-16
CA2327325C (en) 2006-01-24
US6296831B1 (en) 2001-10-02
EP1069919B1 (en) 2005-06-08
DE69925722T2 (en) 2005-12-15
WO1999055386A2 (en) 1999-11-04
DE69925722D1 (en) 2005-07-14
JP2002512987A (en) 2002-05-08
AU752477B2 (en) 2002-09-19
ATE297224T1 (en) 2005-06-15

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