CA2334228A1 - Bioengineered vascular graft support prostheses - Google Patents

Bioengineered vascular graft support prostheses Download PDF

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Publication number
CA2334228A1
CA2334228A1 CA002334228A CA2334228A CA2334228A1 CA 2334228 A1 CA2334228 A1 CA 2334228A1 CA 002334228 A CA002334228 A CA 002334228A CA 2334228 A CA2334228 A CA 2334228A CA 2334228 A1 CA2334228 A1 CA 2334228A1
Authority
CA
Canada
Prior art keywords
mixture
carbon atoms
pressure
general formula
addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002334228A
Other languages
French (fr)
Other versions
CA2334228C (en
Inventor
Ginger A. Abraham
Robert M. Carr, Jr.
Tam Huynh
Mark Davies
Per Otto Hagen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organogenesis Inc
School of Medicine of Duke University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2334228A1 publication Critical patent/CA2334228A1/en
Application granted granted Critical
Publication of CA2334228C publication Critical patent/CA2334228C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3629—Intestinal tissue, e.g. small intestinal submucosa
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C53/00—Shaping by bending, folding, twisting, straightening or flattening; Apparatus therefor
    • B29C53/36—Bending and joining, e.g. for making hollow articles
    • B29C53/38—Bending and joining, e.g. for making hollow articles by bending sheets or strips at right angles to the longitudinal axis of the article being formed and joining the edges
    • B29C53/40—Bending and joining, e.g. for making hollow articles by bending sheets or strips at right angles to the longitudinal axis of the article being formed and joining the edges for articles of definite length, i.e. discrete articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C53/00—Shaping by bending, folding, twisting, straightening or flattening; Apparatus therefor
    • B29C53/56—Winding and joining, e.g. winding spirally
    • B29C53/562—Winding and joining, e.g. winding spirally spirally

Abstract

The invention is directed to bioengineered vascular graft support prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.

Claims (11)

1. A self-supporting pressure-sensitively adhesive shaped article having a first and a second pressure-sensitively adhesive surface and a glass transition temperature (Tg) of less than 10°C, comprising at least 90% by weight of a binder and from 0.01 to 1.44% by weight of an aliphatic or cycloaliphatic nonionic surfactant, the binder present comprising at least one addition polymer or addition copolymer and the first and second pressure-sensitively adhesive surfaces having an essentially identical bond strength with respect to identical material surfaces.
2. The article as claimed in claim 1, characterized in that the nonionic surfactant present comprises a compound or a mixture of two or more compounds of the general formula I

R1[-(O-CRH-CH2-)nO-CR2-CH2-OH]Y

in which R1 in each case independently represents a linear or branched, saturated or unsaturated alkyl radical of 2 to 26 carbon atoms, optionally substituted by secondary or tertiary OH groups, or a mono- or polycyclic cycloalkyl radical of 4 to 26 carbon atoms, optionally substituted by secondary or tertiary OH groups, R2 represents hydrogen or a linear or branched alkyl radical of 1 to about 10 carbon atoms, n represents a number from 0 to 200 and y represents a number from 1 to 6 , or an alkyl polyglycoside or a mixture of two or more alkyl polyglycosides of the general formula II

R3O-(2)x where R3 independently represents a linear or branched, saturated or unsaturated alkyl radical of 2 to 24 carbon atoms, Z independently at each occurrence represents a monosaccharide or oligosaccharide of a sugar having 5 or 6 carbon atoms and x represents a number from 1.1 to 5, or a mixture of two or more compounds of the general formula I and II.
3. The article as claimed in one of claims 1 or 2, characterized in that the binder present comprises an addition polymer or a mixture of two or more addition polymers or an addition copolymer or a mixture of two or more addition copolymers, or a mixture of one or more addition polymers and one or more addition copolymers, prepared by addition polymerization of an ester of acrylic acid or of a mixture of two or more esters of acrylic acid or of an ester of methacrylic acid or of a mixture of two or more esters of methacrylic acid, or a mixture of one or more esters of acrylic acid and one or more esters of methacrylic acid, with a linear or branched, saturated or unsaturated alcohol having 1 to 24 carbon atoms, or a mixture of two or more thereof.
4. The article as claimed in one of claims 1 to 3, characterized in that the binder contains at least 50s by weight of polybutyl acrylate.
5. The article as claimed in one of claims 1 to 4, characterized in that the nonionic surfactant present comprises a compound or a mixture of two or more compounds of the general formula I or of the general formula II, or a mixture of two or more compounds of the general formula I and of the general formula II, where R1 and R3 represent a linear or branched alkyl radical of 8 to 16 carbon atoms, R2 represents hydrogen or methyl, Z
represents a glucose radical and x represents a number from 1.1 to 1.4.
6. The article as claimed in one of claims 1 to 5, characterized in that the nonionic surfactant is present in an amount of from 0.05 to 0.8% by weight.
7. The article as claimed in one of claims 1 to 6, characterized in that the binder is present in an amount of at least 95% by weight.
8. The use of a compound or of a mixture of two or more compounds of the general formula I

R1[~(O~CR2H~CH2~)n O~CR2H~CH2~OH]y (I), in which R1 in each case independently represents a linear or branched, saturated or unsaturated alkyl radical of 2 to 26 carbon atoms, optionally substituted by secondary or tertiary OH groups, or a mono- or polycyclic cycloalkyl radical of 4 to 26 carbon atoms, optionally substituted by secondary or tertiary OH groups, R2 represents hydrogen or a linear or branched alkyl radical of 1 to about 10 carbon atoms, n represents a number from 0 to 200 and y represents a number from 1 to 6, or an alkyl polyglycoside or a mixture of two or more alkyl polyglycosides of the general formula II

R3O~(Z)x~(II), where R2 independently at each occurrence represents a linear or branched, saturated or unsaturated alkyl radical of 2 to 24 carbon atoms, Z independently at each occurrence represents a monosaccharide or oligosaccharide of a sugar having 5 or 6 carbon atoms and x represents a number from 1.1 to 5, or a mixture of two or more compounds of the general formula I and II, for adjusting the bond strength of a pressure-sensitively adhesive shaped article.
9. The use as claimed in claim 8, characterized in that the pressure-sensitively adhesive shaped article has a glass transition temperature of less than 10°C and comprises at least 90% by weight of an addition polymer or addition copolymer or a mixture thereof.
10. A process for producing a pressure-sensitively adhesive shaped article, in which an aqueous dispersion, comprising an addition polymer or an addition copolymer or a mixture thereof, which after drying gives a pressure-sensitively adhesive shaped article, is mixed with from 0.01 to 1.44%
by weight of an aliphatic or cycloaliphatic nonionic surfactant and processed to a pressure-sensitively adhesive shaped article.
11. A method of adjusting the bond strength of a pressure-sensitively adhesive shaped article, in which an aqueous dispersion of an addition polymer or of an addition copolymer or a mixture thereof, which after drying gives a pressure-sensitively adhesive shaped article, is mixed with from 0.01 to 1.44% by weight of an aliphatic or cycloaliphatic nonionic surfactant and processed to a pressure-sensitively adhesive shaped article.
CA2334228A 1998-06-05 1999-06-04 Bioengineered vascular graft support prostheses Expired - Lifetime CA2334228C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8819898P 1998-06-05 1998-06-05
US60/088,198 1998-06-05
PCT/US1999/012500 WO1999062427A1 (en) 1998-06-05 1999-06-04 Bioengineered vascular graft support prostheses

Publications (2)

Publication Number Publication Date
CA2334228A1 true CA2334228A1 (en) 1999-12-09
CA2334228C CA2334228C (en) 2010-09-28

Family

ID=22209955

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2334228A Expired - Lifetime CA2334228C (en) 1998-06-05 1999-06-04 Bioengineered vascular graft support prostheses

Country Status (7)

Country Link
US (2) US6572650B1 (en)
EP (1) EP1083843A4 (en)
JP (1) JP4356053B2 (en)
AU (1) AU763724B2 (en)
CA (1) CA2334228C (en)
MX (1) MXPA00012063A (en)
WO (1) WO1999062427A1 (en)

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CA2334228C (en) 2010-09-28
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JP4356053B2 (en) 2009-11-04
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