CA2334887A1 - Method and apparatus for producing platelet rich plasma and/or platelet concentrate - Google Patents

Method and apparatus for producing platelet rich plasma and/or platelet concentrate Download PDF

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Publication number
CA2334887A1
CA2334887A1 CA002334887A CA2334887A CA2334887A1 CA 2334887 A1 CA2334887 A1 CA 2334887A1 CA 002334887 A CA002334887 A CA 002334887A CA 2334887 A CA2334887 A CA 2334887A CA 2334887 A1 CA2334887 A1 CA 2334887A1
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CA
Canada
Prior art keywords
chamber
supernatant
centrifugation
subjecting
platelet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002334887A
Other languages
French (fr)
Other versions
CA2334887C (en
Inventor
Lou Blasetti
Sherwin V. Kevy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Harvest Technologies Corp
Original Assignee
Harvest Technologies Corporation
Lou Blasetti
Sherwin V. Kevy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvest Technologies Corporation, Lou Blasetti, Sherwin V. Kevy filed Critical Harvest Technologies Corporation
Publication of CA2334887A1 publication Critical patent/CA2334887A1/en
Application granted granted Critical
Publication of CA2334887C publication Critical patent/CA2334887C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/029—Separating blood components present in distinct layers in a container, not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
    • B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B5/0414—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles comprising test tubes
    • B04B5/0421—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles comprising test tubes pivotably mounted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0415—Plasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0427—Platelets; Thrombocytes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2221/00—Applications of separation devices
    • B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues

Abstract

Platelet rich plasma and/or platelet concentrate is prepared by placing whole blood in a first chamber (6) of a sterile processing disposable having two chambers (6, 8). The processing disposable is subjected to a first centrifugation to separate red blood cells (36), and the resulting platelet rich plasma supernatant (38) is decanted to the second chamber (8). The processing disposable is subjected to a second centrifugation to concentrate platelets. A volume of the platelet poor plasma supernatant in the second chamber (8) is removed, and the platelets are re-suspended in the remaining plasma. The second chamber (8) may contain anticoagulant (34) to preclude aggregation of the platelets.

Claims (8)

1. A method for producing a physiological product of selected composition comprising the steps of:
placing a physiological fluid having a plurality of components in a first chamber of a sterile container having first and second chambers;
subjecting said physiological fluid to centrifugation to separate at least one of said components from a first supernatant;
decanting said first supernatant to said second chamber;
subjecting said first supernatant to centrifugation to separate a second of said components from a second supernatant;
removing a predetermined amount of said second supernatant from said second chamber whereby a remainder of said second supernatant is in said second chamber; and re-suspending said second of said components in said remainder of said second supernatant in said second chamber.
2. A method according to claim 1 further comprising the step of placing anticoagulant in said second chamber.
3. A method according to claim 1 wherein said physiological fluid is blood.
4. A method according to claim 3 wherein said physiological product is platelet rich plasma and said step of subjecting said physiological fluid to centrifugation comprises subjecting blood to a first centrifugation for about two minutes.
5. A method according to claim 4 wherein said step of subjecting said first supernatant to centrifugation comprises subjecting platelet rich plasma to a second centrifugation for about eight minutes.
6. Apparatus for producing a physiological product comprising:
a sterile container having first and second chambers;
a centrifuge for removably receiving said container; and means for causing said centrifuge effect a process consisting essentially of the steps of subjecting a physiological fluid in said first chamber to centrifugation, decanting automatically a first supernatant from said first chamber to said second chamber, and subjecting said supernatant in said second chamber to centrifugation.
7. Apparatus according to claim 6 wherein at least one of said chambers of said sterile container has an access port allowing sterile access to said second chamber.
8. Apparatus according to claim 7 wherein said access port allows access to said second chamber by a blunt cannula.
CA2334887A 1999-04-12 2000-04-11 Method and apparatus for producing platelet rich plasma and/or platelet concentrate Expired - Fee Related CA2334887C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12880099P 1999-04-12 1999-04-12
US60/128,800 1999-04-12
PCT/US2000/008718 WO2000061256A1 (en) 1999-04-12 2000-04-11 Method and apparatus for producing platelet rich plasma and/or platelet concentrate

Publications (2)

Publication Number Publication Date
CA2334887A1 true CA2334887A1 (en) 2000-10-19
CA2334887C CA2334887C (en) 2012-01-24

Family

ID=22437036

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2334887A Expired - Fee Related CA2334887C (en) 1999-04-12 2000-04-11 Method and apparatus for producing platelet rich plasma and/or platelet concentrate

Country Status (8)

Country Link
US (1) US6398972B1 (en)
EP (1) EP1093390B1 (en)
JP (1) JP4892133B2 (en)
CN (1) CN1238083C (en)
CA (1) CA2334887C (en)
ES (1) ES2424618T3 (en)
HK (1) HK1037987A1 (en)
WO (1) WO2000061256A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201900015707A1 (en) 2019-09-05 2021-03-05 Emotec Srl "MEDICAL DEVICE AND APPARATUS FOR THE PRODUCTION, WITH CLOSED CIRCUIT, OF PLASMA RICH IN PLATES AND DERIVATIVES, FOR NON-TRANSFUSIONAL USE"

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IT201900015707A1 (en) 2019-09-05 2021-03-05 Emotec Srl "MEDICAL DEVICE AND APPARATUS FOR THE PRODUCTION, WITH CLOSED CIRCUIT, OF PLASMA RICH IN PLATES AND DERIVATIVES, FOR NON-TRANSFUSIONAL USE"

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ES2424618T3 (en) 2013-10-07
HK1037987A1 (en) 2002-03-01
EP1093390A4 (en) 2009-03-04
EP1093390B1 (en) 2013-05-08
CA2334887C (en) 2012-01-24
CN1238083C (en) 2006-01-25
WO2000061256A1 (en) 2000-10-19
JP4892133B2 (en) 2012-03-07
EP1093390A1 (en) 2001-04-25
US6398972B1 (en) 2002-06-04
CN1300233A (en) 2001-06-20

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