CA2339252A1 - Treatment of pigmented tissues using optical energy - Google Patents

Treatment of pigmented tissues using optical energy Download PDF

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Publication number
CA2339252A1
CA2339252A1 CA002339252A CA2339252A CA2339252A1 CA 2339252 A1 CA2339252 A1 CA 2339252A1 CA 002339252 A CA002339252 A CA 002339252A CA 2339252 A CA2339252 A CA 2339252A CA 2339252 A1 CA2339252 A1 CA 2339252A1
Authority
CA
Canada
Prior art keywords
tissues
pigmented
treatment
optical energy
pigmented tissues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002339252A
Other languages
French (fr)
Other versions
CA2339252C (en
Inventor
H. Craig Dees
Eric A. Wachter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Provectus Devicetech Inc
Original Assignee
Photogen, Inc.
H. Craig Dees
Eric A. Wachter
Valley Pharmaceuticals, Inc.
Xantech Pharmaceuticals, Inc.
Provectus Devicetech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Photogen, Inc., H. Craig Dees, Eric A. Wachter, Valley Pharmaceuticals, Inc., Xantech Pharmaceuticals, Inc., Provectus Devicetech, Inc. filed Critical Photogen, Inc.
Publication of CA2339252A1 publication Critical patent/CA2339252A1/en
Application granted granted Critical
Publication of CA2339252C publication Critical patent/CA2339252C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/203Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743Type of operation; Specification of treatment sites
    • A61B2017/00747Dermatology
    • A61B2017/00769Tattoo removal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452Skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452Skin
    • A61B2018/00458Deeper parts of the skin, e.g. treatment of vascular disorders or port wine stains
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452Skin
    • A61B2018/0047Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452Skin
    • A61B2018/00476Hair follicles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/062Photodynamic therapy, i.e. excitation of an agent

Abstract

This invention is a method, and apparatus for selectively photo-bleaching or killing pigmented tissues by photochemically converting pigments in the tissues using light (82), and specifically two photon excitation. Photo-toxic products thereby produced then kill pigmented cells. Hyperthermia or an exogenous agent can also be added to augment efficacy. The present invention is also directed to selective thermal destruction of pigmented tissues using related optical means.
CA002339252A 1998-08-06 1999-07-29 Treatment of pigmented tissues using optical energy Expired - Lifetime CA2339252C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/130,213 US7036516B1 (en) 1996-10-30 1998-08-06 Treatment of pigmented tissues using optical energy
US09/130,213 1998-08-06
PCT/US1999/017176 WO2000007514A1 (en) 1998-08-06 1999-07-29 Treatment of pigmented tissues using optical energy

Publications (2)

Publication Number Publication Date
CA2339252A1 true CA2339252A1 (en) 2000-02-17
CA2339252C CA2339252C (en) 2008-02-12

Family

ID=22443604

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002339252A Expired - Lifetime CA2339252C (en) 1998-08-06 1999-07-29 Treatment of pigmented tissues using optical energy

Country Status (12)

Country Link
US (2) US7036516B1 (en)
EP (1) EP1100394A4 (en)
JP (1) JP4662631B2 (en)
KR (1) KR20010072306A (en)
CN (1) CN1317951A (en)
AR (1) AR020337A1 (en)
AU (1) AU760418B2 (en)
BR (1) BR9912776A (en)
CA (1) CA2339252C (en)
HK (1) HK1040175A1 (en)
IL (2) IL141243A0 (en)
WO (1) WO2000007514A1 (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6517532B1 (en) 1997-05-15 2003-02-11 Palomar Medical Technologies, Inc. Light energy delivery head
AU7568698A (en) 1997-05-15 1998-12-08 General Hospital Corporation, The Method and apparatus for dermatology treatment
DE69926348T2 (en) 1998-03-12 2006-06-01 Palomar Medical Technologies, Inc., Burlington SYSTEM FOR THE ELECTROMAGNETIC IRRADIATION OF THE SKIN
US20060212025A1 (en) 1998-11-30 2006-09-21 Light Bioscience, Llc Method and apparatus for acne treatment
US9192780B2 (en) 1998-11-30 2015-11-24 L'oreal Low intensity light therapy for treatment of retinal, macular, and visual pathway disorders
US6283956B1 (en) 1998-11-30 2001-09-04 David H. McDaniels Reduction, elimination, or stimulation of hair growth
US6887260B1 (en) 1998-11-30 2005-05-03 Light Bioscience, Llc Method and apparatus for acne treatment
US7363071B2 (en) * 1999-05-26 2008-04-22 Endocare, Inc. Computer guided ablation of tissue using integrated ablative/temperature sensing devices
ES2620785T3 (en) 2000-06-01 2017-06-29 The General Hospital Corporation Selective photocoagulation
RU2167625C1 (en) * 2000-09-12 2001-05-27 Владимир Валентинович Хомченко Method for making laser epilation
CN101194855B (en) * 2000-12-28 2013-02-27 帕洛玛医疗技术有限公司 Methods and products for producing lattices of EMR-treated islets in tissues, and uses therefor
JP2005535370A (en) 2002-06-19 2005-11-24 パロマー・メディカル・テクノロジーズ・インコーポレイテッド Method and apparatus for treating skin and subcutaneous conditions
EP1555948A2 (en) 2002-10-23 2005-07-27 Palomar Medical Technologies, Inc. Phototreatment device for use with coolants and topical substances
US20110040295A1 (en) * 2003-02-28 2011-02-17 Photometics, Inc. Cancer treatment using selective photo-apoptosis
US7354433B2 (en) * 2003-02-28 2008-04-08 Advanced Light Technologies, Llc Disinfection, destruction of neoplastic growth, and sterilization by differential absorption of electromagnetic energy
CA2531099A1 (en) 2003-04-10 2004-10-28 Light Bioscience, Llc Photomodulation methods and devices for regulating cell proliferation and gene expression
AU2003292591A1 (en) * 2003-06-20 2005-01-04 Keio University Photodynamic therapy apparatus, method for controlling photodynamic therapy apparatus, and photodynamic therapy method
CN101247768A (en) 2003-07-31 2008-08-20 莱特生物科学有限公司 System and method for the photodynamic treatment of burns, wounds, and related skin disorders
CA2437638A1 (en) * 2003-08-20 2005-02-20 John Robert North Photodynamic therapy
US20050053895A1 (en) 2003-09-09 2005-03-10 The Procter & Gamble Company Attention: Chief Patent Counsel Illuminated electric toothbrushes emitting high luminous intensity toothbrush
US7856985B2 (en) 2005-04-22 2010-12-28 Cynosure, Inc. Method of treatment body tissue using a non-uniform laser beam
EP1889039B1 (en) * 2005-05-31 2015-04-22 W.O.M. World of Medicine AG Method and apparatus for optical characterization of tissue
US8033284B2 (en) 2006-01-11 2011-10-11 Curaelase, Inc. Therapeutic laser treatment
US7586957B2 (en) 2006-08-02 2009-09-08 Cynosure, Inc Picosecond laser apparatus and methods for its operation and use
EP2051776A2 (en) * 2006-08-09 2009-04-29 Koninklijke Philips Electronics N.V. A device for and a method of activating a physiologically effective substance by ultrasonic waves, and a capsule
US20090035576A1 (en) * 2006-09-08 2009-02-05 Prasad Paras N Nanoparticles for two-photon activated photodynamic therapy and imaging
US20080233051A1 (en) * 2006-09-08 2008-09-25 Prasad Paras N Nanoparticles for two-photon activated photodynamic therapy and imaging
US20080082149A1 (en) * 2006-09-13 2008-04-03 Bernstein Eric F Laser treatment of pigmented lesions on the skin
CA2712951A1 (en) * 2008-01-18 2009-07-23 The General Hospital Corporation Selective photostimulation to induce cell proliferation
WO2010085650A2 (en) 2009-01-23 2010-07-29 The General Hospital Corporation Dose determination for inducing microcavitation in retinal pigment epithelium (rpe)
US9919168B2 (en) 2009-07-23 2018-03-20 Palomar Medical Technologies, Inc. Method for improvement of cellulite appearance
US20110172746A1 (en) * 2010-01-12 2011-07-14 Roger Porter High Level Laser Therapy Apparatus and Methods
US9095414B2 (en) 2011-06-24 2015-08-04 The Regents Of The University Of California Nonlinear optical photodynamic therapy (NLO-PDT) of the cornea
WO2013047261A1 (en) * 2011-09-27 2013-04-04 テルモ株式会社 Abrasion device
KR102183581B1 (en) 2012-04-18 2020-11-27 싸이노슈어, 엘엘씨 Picosecond laser apparatus and methods for treating target tissues with same
WO2014145179A1 (en) * 2013-03-15 2014-09-18 The General Hospital Corporation Apparatus for tissue irradiation and methods and kits utilizing the same
WO2014055960A1 (en) 2012-10-05 2014-04-10 Genelux Corporation Energy absorbing-based diagnostic and therapeutic methods employing nucleic acid molecules encoding chromophore-producing enzymes
US10589120B1 (en) 2012-12-31 2020-03-17 Gary John Bellinger High-intensity laser therapy method and apparatus
EP3751684A1 (en) 2013-03-15 2020-12-16 Cynosure, Inc. Picosecond optical radiation systems and methods of use
ES2707725T3 (en) * 2013-08-09 2019-04-04 Massachusetts Gen Hospital Treatment device for dermal melasma
US9907975B1 (en) 2014-11-19 2018-03-06 Roger D. Porter Therapeutic laser treatment and transdermal stimulation of stem cell differentiation
WO2019165426A1 (en) 2018-02-26 2019-08-29 Cynosure, Inc. Q-switched cavity dumped sub-nanosecond laser
US10799292B2 (en) 2018-05-04 2020-10-13 Bin Rao High power tunable optical parametric oscillator for selective photothermolysis laser surgeries
US11160685B1 (en) * 2021-03-24 2021-11-02 Stroma Medical Corporation Laser systems and methods for alteration of eye color

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4378806A (en) 1980-08-12 1983-04-05 Henley Cohn Julian L Gapped resonant microwave apparatus for producing hyperthermia therapy of tumors
US4846789A (en) 1982-07-19 1989-07-11 L. S. Van Landingham, Jr. Combatting internal parasites in warm blooded animals
US4490543A (en) 1982-11-12 1984-12-25 University Of Northern Iowa Foundation Low toxicity radiation sensitizer
US4647578A (en) 1983-12-02 1987-03-03 Sterling Drug Inc. Phototoxic insecticidal compositions and method of use thereof
US5150712A (en) 1983-12-14 1992-09-29 Edap International, S.A. Apparatus for examining and localizing tumors using ultra sounds, comprising a device for localized hyperthermia treatment
US4601037A (en) 1984-06-13 1986-07-15 Britt Corporation Pulsed laser system
JPS63111886A (en) * 1986-10-29 1988-05-17 呉羽化学工業株式会社 Cancer remedy apparatus using optical diode
JPS63216579A (en) * 1987-03-05 1988-09-08 大工園 則雄 Laser beam irradiation apparatus for hyperthermia
US4891043A (en) 1987-05-28 1990-01-02 Board Of Trustees Of The University Of Illinois System for selective release of liposome encapsulated material via laser radiation
US5089384A (en) 1988-11-04 1992-02-18 Amoco Corporation Method and apparatus for selective cell destruction using amplified immunofluorescence
US6099522A (en) 1989-02-06 2000-08-08 Visx Inc. Automated laser workstation for high precision surgical and industrial interventions
US5099756A (en) 1989-06-01 1992-03-31 Harry H. Leveen Radio frequency thermotherapy
US4973848A (en) * 1989-07-28 1990-11-27 J. Mccaughan Laser apparatus for concurrent analysis and treatment
JP2882814B2 (en) * 1989-08-24 1999-04-12 株式会社エス・エル・ティ・ジャパン Laser irradiation equipment
JP2935519B2 (en) 1989-08-28 1999-08-16 シーキンス,ケイ・マイケル Lung cancer hyperthermia treatment via convection with ultrasound and / or perfluorocarbon liquid
JP3046315B2 (en) * 1989-09-05 2000-05-29 株式会社エス・エル・ティ・ジャパン Laser irradiation equipment
US5034613A (en) 1989-11-14 1991-07-23 Cornell Research Foundation, Inc. Two-photon laser microscopy
US5066291A (en) 1990-04-25 1991-11-19 Cincinnati Sub-Zero Products, Inc. Solid-state laser frequency conversion system
US5429582A (en) 1991-06-14 1995-07-04 Williams; Jeffery A. Tumor treatment
US5540737A (en) 1991-06-26 1996-07-30 Massachusetts Institute Of Technology Minimally invasive monopole phased array hyperthermia applicators and method for treating breast carcinomas
US5217455A (en) * 1991-08-12 1993-06-08 Tan Oon T Laser treatment method for removing pigmentations, lesions, and abnormalities from the skin of a living human
US5222953A (en) 1991-10-02 1993-06-29 Kambiz Dowlatshahi Apparatus for interstitial laser therapy having an improved temperature sensor for tissue being treated
US5226907A (en) 1991-10-29 1993-07-13 Tankovich Nikolai I Hair removal device and method
US5590141A (en) * 1992-04-24 1996-12-31 Electro Scientific Industries, Inc. Method and apparatus for generating and employing a high density of excited ions in a lasant
US5329398A (en) * 1992-11-05 1994-07-12 Novatec Laser Systems, Inc. Single grating laser pulse stretcher and compressor
US5620479A (en) 1992-11-13 1997-04-15 The Regents Of The University Of California Method and apparatus for thermal therapy of tumors
US5707403A (en) * 1993-02-24 1998-01-13 Star Medical Technologies, Inc. Method for the laser treatment of subsurface blood vessels
DE69418248T2 (en) * 1993-06-03 1999-10-14 Hamamatsu Photonics Kk Optical laser scanning system with Axikon
US5549596A (en) * 1993-07-07 1996-08-27 The General Hospital Corporation Selective laser targeting of pigmented ocular cells
US5860967A (en) 1993-07-21 1999-01-19 Lucid, Inc. Dermatological laser treatment system with electronic visualization of the area being treated
US5445608A (en) * 1993-08-16 1995-08-29 James C. Chen Method and apparatus for providing light-activated therapy
EP0649667B1 (en) * 1993-10-20 2001-02-28 Antonella Aprile Carpenter Quantum energy therapeutic biostimulation apparatus
US5663114A (en) 1993-10-22 1997-09-02 Nippon Shokubai Co., Ltd. Catalyst for production of pyromellitic anhydride and method for production of pyromellitic anhydride
US5647866A (en) 1993-11-09 1997-07-15 Zaias; Nardo Method of hair depilation
IL108918A (en) * 1994-03-10 1997-04-15 Medic Lightech Ltd Apparatus for efficient photodynamic treatment
US5656186A (en) * 1994-04-08 1997-08-12 The Regents Of The University Of Michigan Method for controlling configuration of laser induced breakdown and ablation
US5469454A (en) * 1994-05-02 1995-11-21 University Of Central Florida Mode locked laser diode in a high power solid state regenerative amplifier and mount mechanism
US5586981A (en) * 1994-08-25 1996-12-24 Xin-Hua Hu Treatment of cutaneous vascular and pigmented lesions
US5556992A (en) 1994-09-02 1996-09-17 Universite De Montreal Novel rhodamine derivatives for photodynamic therapy of cancer and in vitro purging of the leukemias
US5669916A (en) 1994-09-28 1997-09-23 The General Hospital Corporation Method of hair removal
US5735844A (en) 1995-02-01 1998-04-07 The General Hospital Corporation Hair removal using optical pulses
US5541947A (en) 1995-05-10 1996-07-30 The Regents Of The University Of Michigan Selectively triggered, high contrast laser
US5571152A (en) * 1995-05-26 1996-11-05 Light Sciences Limited Partnership Microminiature illuminator for administering photodynamic therapy
US5658323A (en) * 1995-07-12 1997-08-19 Miller; Iain D. Method and apparatus for dermatology treatment
IT1275571B (en) 1995-07-19 1997-08-07 Consiglio Nazionale Ricerche FLUOROGENIC SUBSTRATES SUSCEPTIBLE FOR PHOTOACTIVATION AFTER ENZYMATIC TRANSFORMATION SUITABLE FOR DIAGNOSIS AND PHOTODYNAMIC CANCER THERAPY
US5720894A (en) 1996-01-11 1998-02-24 The Regents Of The University Of California Ultrashort pulse high repetition rate laser system for biological tissue processing
DE19602295C2 (en) 1996-01-23 2003-08-14 Deutsches Krebsforsch Use of a conjugate of a compound capable of fluorescence, cyanuric chloride or a derivative thereof as a linker and a protein
NZ331977A (en) * 1996-03-26 2000-07-28 Pharmacyclics Inc Texaphyrin in photodynamic therapy of pigment-related lesions
US5952818A (en) 1996-05-31 1999-09-14 Rensselaer Polytechnic Institute Electro-optical sensing apparatus and method for characterizing free-space electromagnetic radiation
US5829448A (en) 1996-10-30 1998-11-03 Photogen, Inc. Method for improved selectivity in photo-activation of molecular agents
US6331286B1 (en) 1998-12-21 2001-12-18 Photogen, Inc. Methods for high energy phototherapeutics
US5957960A (en) * 1997-05-05 1999-09-28 Light Sciences Limited Partnership Internal two photon excitation device for delivery of PDT to diffuse abnormal cells
US6272156B1 (en) * 1998-01-28 2001-08-07 Coherent, Inc. Apparatus for ultrashort pulse transportation and delivery
US6676655B2 (en) * 1998-11-30 2004-01-13 Light Bioscience L.L.C. Low intensity light therapy for the manipulation of fibroblast, and fibroblast-derived mammalian cells and collagen
US6554825B1 (en) * 2000-05-09 2003-04-29 Laserscope Variable pulse duration, adjustable wavelength medical laser system

Also Published As

Publication number Publication date
HK1040175A1 (en) 2002-05-31
CN1317951A (en) 2001-10-17
AR020337A1 (en) 2002-05-08
EP1100394A1 (en) 2001-05-23
WO2000007514A1 (en) 2000-02-17
AU5460799A (en) 2000-02-28
JP2002522110A (en) 2002-07-23
AU760418B2 (en) 2003-05-15
JP4662631B2 (en) 2011-03-30
BR9912776A (en) 2001-05-08
EP1100394A4 (en) 2005-03-16
IL141243A (en) 2006-07-05
WO2000007514A9 (en) 2001-04-19
US7036516B1 (en) 2006-05-02
US20060095101A1 (en) 2006-05-04
IL141243A0 (en) 2002-03-10
CA2339252C (en) 2008-02-12
KR20010072306A (en) 2001-07-31

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Effective date: 20190729