CA2346860A1 - Multi-well microfiltration apparatus - Google Patents

Multi-well microfiltration apparatus Download PDF

Info

Publication number
CA2346860A1
CA2346860A1 CA002346860A CA2346860A CA2346860A1 CA 2346860 A1 CA2346860 A1 CA 2346860A1 CA 002346860 A CA002346860 A CA 002346860A CA 2346860 A CA2346860 A CA 2346860A CA 2346860 A1 CA2346860 A1 CA 2346860A1
Authority
CA
Canada
Prior art keywords
well
provides multi
arrangements
filtrate
array
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002346860A
Other languages
French (fr)
Other versions
CA2346860C (en
Inventor
Stephen E. Moring
Kevin S. Bodner
Jason H. Halsey
Jon Hoshizaki
Joseph Jackson
Alfred P. Madden
Mark F. Oldham
Mark T. Reed
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Biosystems LLC
Original Assignee
Pe Corporation (Ny)
Stephen E. Moring
Kevin S. Bodner
Jason H. Halsey
Jon Hoshizaki
Joseph Jackson
Alfred P. Madden
Mark F. Oldham
Mark T. Reed
The Perkin-Elmer Corporation
Applera Corporation
Applied Biosystems Inc.
Applied Biosystems, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pe Corporation (Ny), Stephen E. Moring, Kevin S. Bodner, Jason H. Halsey, Jon Hoshizaki, Joseph Jackson, Alfred P. Madden, Mark F. Oldham, Mark T. Reed, The Perkin-Elmer Corporation, Applera Corporation, Applied Biosystems Inc., Applied Biosystems, Llc filed Critical Pe Corporation (Ny)
Priority to CA002478306A priority Critical patent/CA2478306A1/en
Publication of CA2346860A1 publication Critical patent/CA2346860A1/en
Application granted granted Critical
Publication of CA2346860C publication Critical patent/CA2346860C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00475—Filters
    • G01N2035/00485—Filters combined with sample carriers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • G01N2035/102—Preventing or detecting loss of fluid by dripping
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1074—Multiple transfer devices arranged in a two-dimensional array
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation

Abstract

The present invention provides multi-well plates and column arrays in which samples (e.g., cell lysates containing nucleic acids of interest, such as RNA) can be analyzed and/or processed. In one embodiment, the microfiltration arrangement is a multilayer structure, including: (i) a column plate having an array of minicolumns into which samples can be placed; (ii) a discrete filter element disposed in each minicolumn; (iii) a drip-director plate having a corresponding array of drip directors through which filtrate may egress;
and (iv) a receiving-well plate having a corresponding array of receiving wells into which filtrate can flow. The invention provides multi-well microfiltration arrangements that are relatively simple to manufacture and that overcome many of the problems associated with the prior arrangements relating to:
(i) cross-contamination due to wicking across a common filter sheet or (ii) individual filter elements entrapping sample constituents within substantial dead volumes. Further, the invention provides multi-well microfiltration arrangements that adequately support discrete filter elements disposed in the wells without creating substantial preferential flow.
additionally, the invention provides multi-well microfiltration arrangements that avoid cross-contamination due to aerosol formation, pendant drops and/or splattering. Other disclosed features of the invention provide for the automated covering or heat-sealing of filtrate samples separately collected in an array of wells.
CA002346860A 1998-10-29 1999-10-28 Multi-well microfiltration apparatus Expired - Fee Related CA2346860C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002478306A CA2478306A1 (en) 1998-10-29 1999-10-28 Multi-well microfiltration apparatus

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/182,946 US6159368A (en) 1998-10-29 1998-10-29 Multi-well microfiltration apparatus
US09/182,946 1998-10-29
PCT/US1999/025579 WO2000025922A2 (en) 1998-10-29 1999-10-28 Multi-well microfiltration apparatus

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002478306A Division CA2478306A1 (en) 1998-10-29 1999-10-28 Multi-well microfiltration apparatus

Publications (2)

Publication Number Publication Date
CA2346860A1 true CA2346860A1 (en) 2000-05-11
CA2346860C CA2346860C (en) 2005-01-04

Family

ID=22670739

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002346860A Expired - Fee Related CA2346860C (en) 1998-10-29 1999-10-28 Multi-well microfiltration apparatus

Country Status (9)

Country Link
US (6) US6159368A (en)
EP (2) EP1124637B1 (en)
JP (3) JP3725029B2 (en)
AT (1) ATE257036T1 (en)
AU (1) AU756147B2 (en)
CA (1) CA2346860C (en)
DE (1) DE69913978T2 (en)
ES (1) ES2212652T3 (en)
WO (1) WO2000025922A2 (en)

Families Citing this family (272)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7560273B2 (en) 2002-07-23 2009-07-14 Applied Biosystems, Llc Slip cover for heated platen assembly
US6121048A (en) * 1994-10-18 2000-09-19 Zaffaroni; Alejandro C. Method of conducting a plurality of reactions
US6117394A (en) * 1996-04-10 2000-09-12 Smith; James C. Membrane filtered pipette tip
DE19725894A1 (en) * 1997-06-19 1998-12-24 Biotechnolog Forschung Gmbh Differential vacuum chamber
US6486947B2 (en) * 1998-07-22 2002-11-26 Ljl Biosystems, Inc. Devices and methods for sample analysis
FR2776389B1 (en) * 1998-03-20 2000-06-16 Fondation Jean Dausset Ceph AUTOMATIC DEVICE FOR PRODUCING SAMPLES FOR THE IMPLEMENTATION OF CHEMICAL OR BIOLOGICAL REACTIONS IN A LIQUID MEDIUM
WO1999054031A1 (en) * 1998-04-23 1999-10-28 Otter Coast Automation, Inc. Method and apparatus for synthesis of libraries of organic compounds
US6436351B1 (en) * 1998-07-15 2002-08-20 Deltagen Research Laboratories, L.L.C. Microtitre chemical reaction system
US6419827B1 (en) * 1998-10-29 2002-07-16 Applera Corporation Purification apparatus and method
US6896849B2 (en) * 1998-10-29 2005-05-24 Applera Corporation Manually-operable multi-well microfiltration apparatus and method
US6159368A (en) * 1998-10-29 2000-12-12 The Perkin-Elmer Corporation Multi-well microfiltration apparatus
US6906292B2 (en) * 1998-10-29 2005-06-14 Applera Corporation Sample tray heater module
US6689323B2 (en) * 1998-10-30 2004-02-10 Agilent Technologies Method and apparatus for liquid transfer
US6485692B1 (en) * 1998-12-04 2002-11-26 Symyx Technologies, Inc. Continuous feed parallel reactor
US6951762B2 (en) * 1998-12-23 2005-10-04 Zuk Jr Peter Apparatus comprising a disposable device and reusable instrument for synthesizing chemical compounds, and for testing chemical compounds for solubility
US6315957B1 (en) * 1999-01-15 2001-11-13 Pharmacopeia, Inc. Article comprising a filter pocket-plate
US6887431B1 (en) * 1999-02-16 2005-05-03 Applera Corporation Bead dispensing system
US6306578B1 (en) * 1999-03-19 2001-10-23 Genencor International, Inc. Multi-through hole testing plate for high throughput screening
GB9906477D0 (en) * 1999-03-19 1999-05-12 Pyrosequencing Ab Liquid dispensing apparatus
WO2000066267A1 (en) * 1999-04-30 2000-11-09 Gentra Systems, Inc. Preventing cross-contamination in a multi-well plate
US6635430B1 (en) * 1999-07-16 2003-10-21 Dupont Pharmaceuticals Company Filtrate plate device and reversible-well plate device
US6379626B1 (en) * 1999-09-03 2002-04-30 Array Biopharma Reactor plate clamping system
US6869572B1 (en) * 1999-09-13 2005-03-22 Millipore Corporation High density cast-in-place sample preparation card
ATE237399T1 (en) 1999-09-29 2003-05-15 Tecan Trading Ag THERMOCYCLER AND LIFTING ELEMENT FOR MICROTITER PLATE
US6272939B1 (en) 1999-10-15 2001-08-14 Applera Corporation System and method for filling a substrate with a liquid sample
FR2801660B1 (en) * 1999-11-29 2002-01-18 Chemunex DEVICE FOR HANDLING A SOLID SUPPORT FOR CONTAMINANTS
US6692596B2 (en) 1999-12-23 2004-02-17 3M Innovative Properties Company Micro-titer plate and method of making same
US7311880B2 (en) * 1999-12-23 2007-12-25 3M Innovative Properties Company Well-less filtration device
EP1110611A1 (en) * 1999-12-23 2001-06-27 3M Innovative Properties Company Micro-titer plate and method of making same
AU2788101A (en) * 2000-01-11 2001-07-24 Maxygen, Inc. Integrated systems and methods for diversity generation and screening
US7169355B1 (en) 2000-02-02 2007-01-30 Applera Corporation Apparatus and method for ejecting sample well trays
US6534014B1 (en) * 2000-05-11 2003-03-18 Irm Llc Specimen plate lid and method of using
GB0011443D0 (en) * 2000-05-13 2000-06-28 Dna Research Instr Limited Separation device
DE60139469D1 (en) * 2000-05-18 2009-09-17 Millipore Corp MULTIPLATE PLATE WITH ADHESIVE FILTER
AU2001272926A1 (en) * 2000-05-26 2001-12-11 Whatman, Inc. Use of membrane cover in prevention of cross-contamination in multiple biological material isolation processing
US6358479B1 (en) * 2000-05-30 2002-03-19 Advanced Chemtech, Inc. Reaction block assembly for chemical synthesis
US6994827B2 (en) * 2000-06-03 2006-02-07 Symyx Technologies, Inc. Parallel semicontinuous or continuous reactors
US6439036B1 (en) 2000-06-13 2002-08-27 Symyx Technologics, Inc. Method for evaluating a test fluid
US6455007B1 (en) * 2000-06-13 2002-09-24 Symyx Technologies, Inc. Apparatus and method for testing compositions in contact with a porous medium
US6627159B1 (en) * 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US6719949B1 (en) * 2000-06-29 2004-04-13 Applera Corporation Apparatus and method for transporting sample well trays
AU2001273317A1 (en) * 2000-07-07 2002-01-21 Symyx Technologies, Inc. Methods for analysis of heterogeneous catalysts in a multi-variable screening reactor
US6563581B1 (en) 2000-07-14 2003-05-13 Applera Corporation Scanning system and method for scanning a plurality of samples
DE10041825A1 (en) * 2000-08-25 2002-03-07 Invitek Gmbh Multiwell filtration plate and process for its manufacture
US6640891B1 (en) * 2000-09-05 2003-11-04 Kevin R. Oldenburg Rapid thermal cycling device
US7070740B1 (en) * 2000-09-28 2006-07-04 Beckman Coulter, Inc. Method and apparatus for processing biomolecule arrays
US6939516B2 (en) * 2000-09-29 2005-09-06 Becton, Dickinson And Company Multi-well plate cover and assembly adapted for mechanical manipulation
US6490782B1 (en) * 2000-10-16 2002-12-10 Varian, Inc. Automated in-line filter changing apparatus
US8097471B2 (en) 2000-11-10 2012-01-17 3M Innovative Properties Company Sample processing devices
SE0102921D0 (en) * 2001-08-30 2001-08-30 Astrazeneca Ab Pharmaceutically useful compounds
US6896848B1 (en) * 2000-12-19 2005-05-24 Tekcel, Inc. Microplate cover assembly
US20040053402A1 (en) * 2000-12-20 2004-03-18 Jacobus Stark Preparation of fluid samples by applying pressure
US20020093147A1 (en) * 2001-01-16 2002-07-18 Berna Michael J. Well plate seal
US6491873B2 (en) * 2001-01-23 2002-12-10 Varian, Inc. Multi-well filtration apparatus
FR2820058B1 (en) * 2001-01-29 2004-01-30 Commissariat Energie Atomique METHOD AND SYSTEM FOR MAKING A CONTINUOUS FLOW REALIZATION OF A BIOLOGICAL, CHEMICAL OR BIOCHEMICAL PROTOCOL
US6899848B1 (en) * 2001-02-27 2005-05-31 Hamilton Company Automated sample treatment system: apparatus and method
MXPA03008081A (en) * 2001-03-08 2004-11-12 Exelixis Inc Multi-well apparatus.
US20050226786A1 (en) * 2001-03-08 2005-10-13 Hager David C Multi-well apparatus
EP1386432A4 (en) * 2001-03-21 2009-07-15 John A Stine An access and routing protocol for ad hoc networks using synchronous collision resolution and node state dissemination
US6426215B1 (en) * 2001-04-06 2002-07-30 Pe Corporation (Ny) PCR plate cover and maintaining device
CA2455345C (en) * 2001-05-31 2009-08-25 Pall Corporation Well for processing a fluid
JP3669996B2 (en) * 2001-06-14 2005-07-13 ミリポア・コーポレイション Locating pins for multiwell test equipment
DE60215377T2 (en) * 2001-06-14 2007-08-23 Millipore Corp., Billerica The multiwell cell growth apparatus
US6514750B2 (en) 2001-07-03 2003-02-04 Pe Corporation (Ny) PCR sample handling device
EP1281966A3 (en) * 2001-07-30 2003-06-18 Fuji Photo Film Co., Ltd. Method and apparatus for conducting a receptor-ligand reaction
US6632371B2 (en) * 2001-08-07 2003-10-14 Abbott Laboratories Method for controlling the proportion of fluid passing through a filter
DE10139758A1 (en) * 2001-08-13 2003-02-27 Qiagen Gmbh Intermediate element, for an automated fluid preparation assembly, comprises a main block with passage openings matching the array of feed channels, leading to a heated plate, without cross contamination or clogging
US7014744B2 (en) 2001-08-24 2006-03-21 Applera Corporation Method of purification and concentration using AC fields with a transfer tip
US6682703B2 (en) * 2001-09-05 2004-01-27 Irm, Llc Parallel reaction devices
DE10144225C1 (en) * 2001-09-08 2003-02-06 Eppendorf Ag Process for drying filters in cavities of micro-titration plate involves using device with nozzles and unit for producing air stream through nozzles
CN1555294A (en) * 2001-09-20 2004-12-15 3-άҩƷ��˾ Conductive microtiter plate
WO2003034026A2 (en) * 2001-10-15 2003-04-24 Biocept, Inc. Microwell biochip
US6942836B2 (en) * 2001-10-16 2005-09-13 Applera Corporation System for filling substrate chambers with liquid
US20030087293A1 (en) * 2001-10-23 2003-05-08 Decode Genetics Ehf. Nucleic acid isolation method and apparatus for performing same
DE10160975A1 (en) * 2001-12-10 2003-06-18 Univ Schiller Jena Sample plate for use in dialysis systems
US7632467B1 (en) * 2001-12-13 2009-12-15 Kardex Engineering, Inc. Apparatus for automated storage and retrieval of miniature shelf keeping units
KR100411946B1 (en) * 2001-12-18 2003-12-18 한국해양연구원 Device for simultaneously collecting filtered water and filter paper
AU2002342499A1 (en) * 2001-12-21 2003-07-09 Tecan Trading Ag Device and method for the transfer of liquid samples
EP1323474A1 (en) * 2001-12-31 2003-07-02 Corning Incorporated Device and process for simultaneous transfer of liquids
GB0200157D0 (en) * 2002-01-04 2002-02-20 Kbiosystems Ltd Sealing method suitable for use with water-based thermal cyclers
US7614444B2 (en) 2002-01-08 2009-11-10 Oldenburg Kevin R Rapid thermal cycling device
US7373968B2 (en) * 2002-01-08 2008-05-20 Kevin R. Oldenburg Method and apparatus for manipulating an organic liquid sample
US6893613B2 (en) * 2002-01-25 2005-05-17 Bristol-Myers Squibb Company Parallel chemistry reactor with interchangeable vessel carrying inserts
US6783737B2 (en) * 2002-01-25 2004-08-31 Bristol-Myers Squibb Company High pressure chemistry reactor
ATE524236T1 (en) * 2002-01-28 2011-09-15 Nanosphere Inc HYBRIDIZATION DEVICE
US6677151B2 (en) 2002-01-30 2004-01-13 Applera Corporation Device and method for thermal cycling
US20030143124A1 (en) * 2002-01-31 2003-07-31 Roberts Roger Q. Unidirectional flow control sealing matt
US6723236B2 (en) * 2002-03-19 2004-04-20 Waters Investments Limited Device for solid phase extraction and method for purifying samples prior to analysis
US20030190260A1 (en) * 2002-04-05 2003-10-09 Symyx Technologies, Inc. Combinatorial chemistry reactor system
US9157860B2 (en) 2002-05-16 2015-10-13 Applied Biosystems, Llc Achromatic lens array
US6982166B2 (en) 2002-05-16 2006-01-03 Applera Corporation Lens assembly for biological testing
US8007745B2 (en) * 2002-05-24 2011-08-30 Millipore Corporation Anti-clogging device and method for in-gel digestion applications
DE50300434D1 (en) * 2002-05-31 2005-05-19 Tecan Trading Ag Maennedorf Apparatus, system and method for aspirating liquids from solid phase extraction plates
EP1511571A2 (en) * 2002-06-06 2005-03-09 Millipore Corporation Ultrafiltration device for drug binding studies
EP1371966A1 (en) * 2002-06-14 2003-12-17 Stiftung Für Diagnostische Forschung A cuvette for a reader device for assaying substances using the evanescence field method
EP1521955A1 (en) * 2002-07-15 2005-04-13 Avantium International B.V. A system for the preparation of multiple solid state samples, in particular for spectroscopic and microscopic analysis
US7122155B2 (en) * 2002-07-16 2006-10-17 Mcgill University Electron microscopy cell fraction sample preparation robot
US7452712B2 (en) 2002-07-30 2008-11-18 Applied Biosystems Inc. Sample block apparatus and method of maintaining a microcard on a sample block
US7241420B2 (en) 2002-08-05 2007-07-10 Palo Alto Research Center Incorporated Capillary-channel probes for liquid pickup, transportation and dispense using stressy metal
US20040050787A1 (en) * 2002-09-13 2004-03-18 Elena Chernokalskaya Apparatus and method for sample preparation and direct spotting eluants onto a MALDI-TOF target
CA2499913A1 (en) * 2002-10-10 2004-04-22 Irm, Llc Capacity altering device, holder and methods of sample processing
US7507376B2 (en) * 2002-12-19 2009-03-24 3M Innovative Properties Company Integrated sample processing devices
CA2521999A1 (en) * 2002-12-20 2004-09-02 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
US20040129676A1 (en) * 2003-01-07 2004-07-08 Tan Roy H. Apparatus for transfer of an array of liquids and methods for manufacturing same
US20040232075A1 (en) * 2003-01-31 2004-11-25 Jason Wells Microfiltration device and method for washing and concentrating solid particles
US6970240B2 (en) * 2003-03-10 2005-11-29 Applera Corporation Combination reader
US20040179971A1 (en) * 2003-03-12 2004-09-16 Becton, Dickinson And Company Method and device for transporting evacuated blood collection tubes
US20070077179A1 (en) * 2003-05-09 2007-04-05 Dirk Schmalz Component used in microprocess control
CA2467131C (en) * 2003-05-13 2013-12-10 Becton, Dickinson & Company Method and apparatus for processing biological and chemical samples
EP1631668A1 (en) * 2003-06-06 2006-03-08 Applera Corporation Purification device for ribonucleic acid in large volumes, and method
US20040251414A1 (en) * 2003-06-10 2004-12-16 Stephan Rodewald Sample matrix for infrared spectroscopy
US20040258563A1 (en) 2003-06-23 2004-12-23 Applera Corporation Caps for sample wells and microcards for biological materials
EP1491258B1 (en) * 2003-06-24 2008-12-03 Millipore Corporation Multifunctional vacuum manifold
US7824623B2 (en) 2003-06-24 2010-11-02 Millipore Corporation Multifunctional vacuum manifold
DE10329983A1 (en) * 2003-06-27 2005-03-31 Siemens Ag Micro-reactor module allows multiple different reactions to be performed simultaneously and to be serviced by a standard automatic micro-titer head, is formed of a multiple recessed base plate which is sealed by a releasable cover plate
WO2005012549A2 (en) * 2003-08-01 2005-02-10 Fqubed, Inc. Apparatus and methods for evaluating the barrier properties of a membrane
US7429356B2 (en) * 2003-08-19 2008-09-30 Fujifilm Corporation Extracting apparatus
US7063216B2 (en) * 2003-09-04 2006-06-20 Millipore Corporation Underdrain useful in the construction of a filtration device
US20050221358A1 (en) * 2003-09-19 2005-10-06 Carrillo Albert L Pressure chamber clamp mechanism
US7460223B2 (en) * 2003-09-19 2008-12-02 Applied Biosystems Inc. Inverted orientation for a microplate
US20050226779A1 (en) * 2003-09-19 2005-10-13 Oldham Mark F Vacuum assist for a microplate
US7570443B2 (en) * 2003-09-19 2009-08-04 Applied Biosystems, Llc Optical camera alignment
US7998435B2 (en) 2003-09-19 2011-08-16 Life Technologies Corporation High density plate filler
US8277760B2 (en) 2003-09-19 2012-10-02 Applied Biosystems, Llc High density plate filler
US20050103703A1 (en) * 2003-09-26 2005-05-19 Stephen Young Method of assembling a filtration plate
US7166212B2 (en) * 2003-09-30 2007-01-23 Chromba, Inc. Multicapillary column for chromatography and sample preparation
US20070017870A1 (en) 2003-09-30 2007-01-25 Belov Yuri P Multicapillary device for sample preparation
US8753588B2 (en) * 2003-10-15 2014-06-17 Emd Millipore Corporation Support and stand-off ribs for underdrain for multi-well device
EP1676906A4 (en) * 2003-10-21 2011-03-09 Fujifilm Corp Nucleic acid separation purification cartridge and process for producing the same
JP4511914B2 (en) * 2003-12-12 2010-07-28 ベクトン・ディキンソン・アンド・カンパニー Membrane mounting method
EP1733240A4 (en) * 2004-03-02 2007-08-22 Dako Denmark As Reagent delivery system, dispensing device and container for a biological staining apparatus
KR100597870B1 (en) * 2004-04-01 2006-07-06 한국과학기술원 Microfluidic chip for high-throughput screening and high-throughput assay
US7584577B2 (en) * 2004-04-06 2009-09-08 Steve E. Esmond Rain and storm water filtration systems
US20050236318A1 (en) * 2004-04-23 2005-10-27 Millipore Corporation Low holdup volume multiwell plate
US20050236317A1 (en) * 2004-04-23 2005-10-27 Millipore Corporation Pendant drop control in a multiwell plate
US20050236319A1 (en) * 2004-04-23 2005-10-27 Millipore Corporation Pendant drop control in a multiwell plate
US7232038B2 (en) * 2004-04-27 2007-06-19 Whitney Steven G Disposable test tube rack
US20050250173A1 (en) * 2004-05-10 2005-11-10 Davis Charles Q Detection device, components of a detection device, and methods associated therewith
US20050282270A1 (en) * 2004-06-21 2005-12-22 Applera Corporation System for thermally cycling biological samples with heated lid and pneumatic actuator
US7618592B2 (en) 2004-06-24 2009-11-17 Millipore Corporation Detachable engageable microarray plate liner
WO2006015012A1 (en) * 2004-07-27 2006-02-09 Protedyne Corporation Method and apparatus for applying pressure diferential to multi-well plate
US20060024209A1 (en) * 2004-07-30 2006-02-02 Agnew Brian J Apparatus, methods, and kits for assaying a plurality of fluid samples for a common analyte
US20060024204A1 (en) * 2004-08-02 2006-02-02 Oldenburg Kevin R Well plate sealing apparatus and method
US7932090B2 (en) * 2004-08-05 2011-04-26 3M Innovative Properties Company Sample processing device positioning apparatus and methods
US7320891B2 (en) * 2004-09-10 2008-01-22 Promega Corporation Methods and kits for isolating sperm cells
DE102004045054A1 (en) * 2004-09-15 2006-03-30 Eppendorf Ag Device for the suction-tight covering of a filter device
US20080145886A1 (en) * 2004-10-07 2008-06-19 Istituto Di Ricerche Di Biologia Molecolare P Ange Assay for Cytochrome P450 Isoforms 3A4 and 3A5
JP2008515426A (en) * 2004-10-07 2008-05-15 メルク エンド カムパニー インコーポレーテッド Cytochrome P450 isoform 2C9 assay
JP4653995B2 (en) * 2004-10-08 2011-03-16 Ｊｓｒ株式会社 Bio-separation filter manufacturing method, bio-separation filter, and bio-separation kit using the same
FR2877859B1 (en) * 2004-11-17 2007-02-16 Memos Soc Par Actions Simplifi REACTOR MULTIPUITS
DE102005001362A1 (en) * 2005-01-11 2006-07-20 Protagen Ag Method and device for quantifying proteins
US20060188409A1 (en) * 2005-01-19 2006-08-24 Irm Llc Multi-well container positioning devices, systems, computer program products, and methods
TWI253957B (en) * 2005-02-04 2006-05-01 Taigen Bioscience Corp Apparatus for processing biochemical sample
US20060177354A1 (en) * 2005-02-04 2006-08-10 Taigen Bioscience Corporation Apparatus for processing biological sample
GB2424417B (en) * 2005-03-24 2008-11-12 Amersham Health As Devices and method for the penetration of a container stopper
US8021611B2 (en) * 2005-04-09 2011-09-20 ProteinSimple Automated micro-volume assay system
US20080124250A1 (en) * 2005-04-09 2008-05-29 Cell Biosciences Inc. Capillary storage and dispensing container for automated micro-volume assay system
DE102005016755B3 (en) * 2005-04-11 2006-11-30 Eppendorf Ag Apparatus, system comprising such apparatus and method for drying cavities in microtiter filter plates and filters disposed therein
JP5038131B2 (en) * 2005-05-17 2012-10-03 ユニバーサル・バイオ・リサーチ株式会社 Filter processing method, filter enclosing chip, and filter processing apparatus
US8968679B2 (en) 2005-05-19 2015-03-03 Emd Millipore Corporation Receiver plate with multiple cross-sections
JP3805352B1 (en) * 2005-05-25 2006-08-02 株式会社エンプラス Fluid handling device and fluid handling unit used therefor
EP1899068A2 (en) * 2005-06-16 2008-03-19 Stratagene California Heat blocks and heating
US20070009394A1 (en) * 2005-06-16 2007-01-11 Bean Robert J Device for loading a multi well plate
FR2887159B1 (en) * 2005-06-20 2007-08-17 Ct Hospitalier Regional De Nan FILTERING WELL OF BIOLOGICAL ANALYSIS
WO2007011867A2 (en) * 2005-07-15 2007-01-25 Applera Corporation Fluid processing device and method
CN101312785B (en) * 2005-09-02 2011-03-30 罗什生命科学公司 Systems, apparatus and methods for vacuum filtration
US20070175897A1 (en) 2006-01-24 2007-08-02 Labcyte Inc. Multimember closures whose members change relative position
US8084005B2 (en) * 2006-01-26 2011-12-27 Lawrence Livermore National Security, Llc Multi-well sample plate cover penetration system
KR20090007692A (en) * 2006-04-20 2009-01-20 다이니폰 인사츠 가부시키가이샤 Filter-carrying micro plate
WO2007130434A2 (en) * 2006-05-02 2007-11-15 Applera Corporation Variable volume dispenser and method
EP1854542B1 (en) * 2006-05-12 2011-03-30 F. Hoffmann-La Roche AG Multi-well filtration device
EP1854540A1 (en) * 2006-05-12 2007-11-14 F. Hoffmann-la Roche AG Multi-well filtration device
US20070272587A1 (en) * 2006-05-22 2007-11-29 Nguyen Viet X Vial package
WO2008002563A2 (en) * 2006-06-26 2008-01-03 Applera Corporation Heated cover methods and technology
WO2008127356A2 (en) * 2006-10-06 2008-10-23 Promega Corporation Methods and kits for isolating cells
EP2125214B1 (en) * 2007-01-12 2013-01-02 HighRes Biosolutions, Inc. Microplate kit
US8221697B2 (en) 2007-01-12 2012-07-17 Nichols Michael J Apparatus for lidding or delidding microplate
JP4996958B2 (en) * 2007-03-29 2012-08-08 富士フイルム株式会社 Microfluidic device
JP2010537797A (en) * 2007-05-23 2010-12-09 ニプロ インク Method and apparatus for the control of foam in a vacuum filtration system
US20080293157A1 (en) * 2007-05-24 2008-11-27 Gerald Frederickson Apparatus and method of performing high-throughput cell-culture studies on biomaterials
US7651867B2 (en) * 2007-06-05 2010-01-26 Gideon Eden Method of making a test device
US20090004754A1 (en) * 2007-06-26 2009-01-01 Oldenburg Kevin R Multi-well reservoir plate and methods of using same
US20090004064A1 (en) * 2007-06-27 2009-01-01 Applera Corporation Multi-material microplate and method
JP5011012B2 (en) * 2007-07-18 2012-08-29 株式会社日立ハイテクノロジーズ Nucleic acid extraction equipment
ATE548095T1 (en) * 2007-07-26 2012-03-15 Roush Life Sciences Llc METHOD AND DEVICE FOR SUPPORTING A VACUUM FILTRATION DEVICE
WO2009014768A1 (en) * 2007-07-26 2009-01-29 Nypro Inc. Method and apparatus for filtrate storage handling
DE102007043614B3 (en) * 2007-09-13 2008-11-20 Biocrates Life Sciences Gmbh Retainer for wells of multi-corrugated plate, has support arranged in opening below retaining bar, where retainer rests with lateral outer surfaces of support bars, retaining bar and/or connecting rods against inner side of opening
US20100256017A1 (en) * 2007-09-17 2010-10-07 Harry Benjamin Larman Supramolecular nanostamping printing device
AU2008308686B2 (en) 2007-10-02 2015-01-22 Labrador Diagnostics Llc Modular point-of-care devices and uses thereof
DE102008008256A1 (en) * 2007-10-08 2009-04-09 M2P-Labs Gmbh microreactor
US20090181359A1 (en) * 2007-10-25 2009-07-16 Lou Sheng C Method of performing ultra-sensitive immunoassays
US8222048B2 (en) 2007-11-05 2012-07-17 Abbott Laboratories Automated analyzer for clinical laboratory
WO2009121034A2 (en) * 2008-03-28 2009-10-01 Pelican Group Holdings, Inc. Multicapillary sample preparation devices and methods for processing analytes
US8076126B2 (en) * 2008-07-18 2011-12-13 Ortho-Clinical Diagnostics, Inc. Single column immunological test elements
GB2477648B (en) * 2008-08-29 2013-02-20 Lee H Angros In situ heat induced antigen recovery and staining apparatus and method
FI20085815A (en) 2008-09-02 2010-03-03 Wallac Oy Apparatus, system and method for filtering liquid samples
JP4675406B2 (en) * 2008-09-29 2011-04-20 日本分光株式会社 Sample collection container, sample collection device, and sample collection method in a supercritical fluid system
WO2010047780A2 (en) * 2008-10-20 2010-04-29 Photonic Biosystems, Inc. Multiple filter array assay
GB0903623D0 (en) * 2009-03-03 2009-04-15 4Titude Ltd Sealing multiwell plates
US8555520B2 (en) * 2009-06-25 2013-10-15 Harvard Bioscience, Inc. Accelerated evaporation process and apparatus utilizing re-circulating loops
WO2011005801A1 (en) * 2009-07-08 2011-01-13 Speware Corporation Luer seal for solid phase extraction columns
WO2011014357A1 (en) * 2009-07-15 2011-02-03 Biosystem Development, Llc Spin column system and methods
DE102009043570A1 (en) * 2009-09-30 2011-03-31 Manz Automation Tübingen GmbH Module for a laboratory robot and laboratory robot
WO2011046915A1 (en) * 2009-10-12 2011-04-21 R.P. Scherer Technologies, Llc Apparatus for crystallization and method therefor
JP5933918B2 (en) 2009-12-10 2016-06-15 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Mold-shaped locking system
JP4924909B2 (en) * 2010-01-12 2012-04-25 株式会社日立プラントテクノロジー Suction air leak prevention mechanism during collection carrier solution filtration and suction air leak prevention method during collection carrier solution filtration
JP5847733B2 (en) 2010-01-28 2016-01-27 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン Hanging drop array plate
DE102010011485A1 (en) * 2010-03-16 2011-09-22 Sartorius Stedim Biotech Gmbh Multi-hole plate with filter medium and its use
EP2447721B1 (en) 2010-11-02 2017-03-15 F. Hoffmann-La Roche AG Instrument and method for automatically heat-sealing a microplate
US9050548B2 (en) 2010-12-22 2015-06-09 Agilent Technologies, Inc. Multi-channel filter assembly and related apparatus and methods
US9157838B2 (en) * 2010-12-23 2015-10-13 Emd Millipore Corporation Chromatography apparatus and method
CN103282123B (en) * 2010-12-30 2015-05-06 艾博特健康公司 Biologic fluid analysis cartridge with sample handling portion and analysis chamber portion
AR085087A1 (en) 2011-01-21 2013-09-11 Theranos Inc SYSTEMS AND METHODS TO MAXIMIZE THE USE OF SAMPLES
EP2710385B1 (en) 2011-05-20 2016-10-19 PerkinElmer Health Sciences, Inc. Liquid handling systems and methods including same
EP3412362B1 (en) * 2011-07-20 2020-04-01 Avidien Technologies Use of a pipette tip adapter
US11559802B2 (en) 2011-07-20 2023-01-24 Avidien Technologies, Inc. Pipette tip adapter
JP5893035B2 (en) * 2011-08-22 2016-03-23 株式会社日立ハイテクノロジーズ Opening device and sample processing device
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US9194865B2 (en) * 2011-12-19 2015-11-24 Yamaha Hatsudoki Kabushiki Kaisha Object selecting device and object selecting method
US20130180171A1 (en) * 2012-01-13 2013-07-18 Kevin Oldenburg Systems and Methods for Harvesting and/or Analyzing Biological Samples
US9073052B2 (en) 2012-03-30 2015-07-07 Perkinelmer Health Sciences, Inc. Lab members and liquid handling systems and methods including same
DK2844564T3 (en) * 2012-05-03 2017-10-23 Vanrx Pharmasystems Inc COVER REMOVAL SYSTEM FOR USE IN CONTROLLED ENVIRONMENTS
US9199237B2 (en) * 2012-09-04 2015-12-01 Michael Baumgartner Automated well plate
JP2014070188A (en) * 2012-09-28 2014-04-21 Sumitomo Bakelite Co Ltd Processing apparatus
JP2014069149A (en) * 2012-09-28 2014-04-21 Sumitomo Bakelite Co Ltd Spacer and processing unit
US9423234B2 (en) 2012-11-05 2016-08-23 The Regents Of The University Of California Mechanical phenotyping of single cells: high throughput quantitative detection and sorting
US8968682B2 (en) * 2013-03-15 2015-03-03 Cytosaver Llc Aspiration-free well plate apparatus and methods
MX2015013421A (en) 2013-03-19 2016-07-05 Life Technologies Corp Thermal cycler cover.
US10188967B2 (en) 2013-12-04 2019-01-29 Pocared Diagnostics Ltd. Filter arrangement with slider valve and method for using the same
DE102013114732A1 (en) * 2013-12-20 2015-06-25 Hamilton Bonaduz Ag Covering device, in particular cover for the cover of reaction vessels
JP6791848B2 (en) 2014-05-21 2020-11-25 アンチェインド ラブス Systems and methods for buffer replacement
CA2957526C (en) 2014-08-08 2023-03-28 Fremon Scientific, Inc. Smart bag used in sensing physiological and/or physical parameters of bags containing biological substance
US10481150B2 (en) * 2014-10-27 2019-11-19 The Governing Council Of The University Of Toronto Microfluidic device for cell-based assays
WO2016081595A1 (en) 2014-11-18 2016-05-26 Avidien Technologies Multichannel air displacement pipettor
US10493449B2 (en) * 2014-11-19 2019-12-03 Halliburton Energy Services, Inc. Loading tool for a multi-well chromatography filter plate
WO2016117541A1 (en) * 2015-01-22 2016-07-28 株式会社村田製作所 Void array structure and method for producing same
DE102015102350B3 (en) * 2015-02-19 2016-05-04 Sartorius Stedim Biotech Gmbh Filtration device for liquid samples
US20160243734A1 (en) * 2015-02-25 2016-08-25 Sony Dadc Austria Ag Microfluidic or microtiter device and method of manufacture of microfluidic or microtiter device
CA2996863C (en) * 2015-09-01 2021-04-13 Becton, Dickinson And Company Depth filtration device for separating specimen phases
IL244922A0 (en) 2016-04-05 2016-07-31 Omrix Biopharmaceuticals Ltd Device and process for sample preparation
US20190193076A1 (en) * 2016-07-14 2019-06-27 Hewlett-Packard Development Company, L.P. Microplate lid
JP6956203B2 (en) * 2017-05-10 2021-11-02 イー・エム・デイー・ミリポア・コーポレイシヨン Multi-well plate with variable compression seal
US10739237B2 (en) 2017-08-02 2020-08-11 Pocared Diagnostics Ltd. Processor filter arrangement that includes method and apparatus to remove waste fluid through a filter
CN107372195B (en) * 2017-09-08 2023-11-14 殷文斐 Multifunctional chicken raising drinking water system
DE102017009147A1 (en) * 2017-09-29 2019-04-04 Sartorius Stedim Biotech Gmbh Filtration device, method for assembling a modular filtration device and method for characterizing a filter medium and / or medium to be filtered
US11648564B2 (en) * 2018-02-02 2023-05-16 Covaris, Llc Well plate drier and cover
US10890514B2 (en) * 2018-04-25 2021-01-12 Optofluidics Inc. Vacuum manifold for filtration microscopy
CN112512603A (en) 2018-05-07 2021-03-16 弗莱蒙科学公司 Thawing biological material
CN108730519B (en) * 2018-07-25 2023-09-29 湖南省天骑医学新技术股份有限公司 Sealant seat with negative pressure supporting platform and manufacturing method
WO2020037194A1 (en) * 2018-08-17 2020-02-20 Sierra Biosystems, Inc. Row-independent oligonucleotide synthesis
US11266179B2 (en) 2019-02-08 2022-03-08 Gravitron, LLC Joint smoking device with plunger or auger
US10604292B1 (en) 2019-02-20 2020-03-31 Gravitron, LLC System, method and apparatus for processing cartridges en masse
USD905267S1 (en) 2019-03-27 2020-12-15 Avidien Technologies, Inc. Pipette tip adapter
US11918054B2 (en) 2020-01-16 2024-03-05 Gravitron, LLC System, method and apparatus for smoking device
CN111589489B (en) * 2020-04-13 2021-10-22 青岛海尔生物医疗股份有限公司 Test tube storage system and storage method
CN111905848B (en) * 2020-09-05 2022-04-01 海易（大连）实业有限公司 Use method of electric heating constant-temperature water bath kettle with good stability
CN112874992B (en) * 2021-01-07 2021-09-21 广州市言康生物科技有限公司 Biological diagnosis kit device
CN116782993A (en) * 2021-02-03 2023-09-19 美国安进公司 System and method for pharmaceutical processing
CN113426173B (en) * 2021-05-21 2023-07-14 新疆农业职业技术学院 Turbid fluid separating device for water-saving irrigation operation
CN113668669B (en) * 2021-08-10 2023-02-10 上海天淼建设工程有限公司 Sewer construction device and method
WO2023218373A1 (en) * 2022-05-11 2023-11-16 Dh Technologies Development Pte. Ltd. Sample well mixing system and method
KR102633789B1 (en) * 2023-03-14 2024-02-02 황하늘 Multi-purpose multi-well device with vacuum chamber

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US297602A (en) * 1884-04-29 Thomas hookeb
US3463322A (en) * 1967-07-28 1969-08-26 Horace W Gerarde Pressure filtration device
US3721364A (en) * 1970-11-17 1973-03-20 Wolfen Filmfab Veb Plastic magazine for photosensitive sheet materials
US3775225A (en) * 1971-07-06 1973-11-27 Gloucester Eng Co Inc Machine for perforating and heat sealing a web including an elongated element with a multiplicity of drivers
US3864892A (en) * 1973-05-29 1975-02-11 Mahaffy & Harder Eng Co Automatic packaging method and apparatus with heat-sealing elements having resilient heat conducting members
US3988168A (en) * 1974-06-10 1976-10-26 Polaroid Corporation Flat battery and manufacture thereof
US3967776A (en) * 1975-03-27 1976-07-06 Pako Corporation Continuous multi-layered packaging assembly
US4167875A (en) * 1976-08-05 1979-09-18 Meakin John C Filtration method and apparatus
DE2962562D1 (en) * 1978-08-31 1982-06-03 Nat Res Dev Apparatus and method for harvesting material from micro-culture plates
US4246339A (en) * 1978-11-01 1981-01-20 Millipore Corporation Test device
US4279342A (en) * 1980-03-24 1981-07-21 Robert Van Pelt Lunch box employing a built-in radio receiver
US4422151A (en) * 1981-06-01 1983-12-20 Gilson Robert E Liquid handling apparatus
US4734192A (en) * 1982-07-01 1988-03-29 Millipore Corporation Multiwell membrane filtration apparatus
US4704255A (en) * 1983-07-15 1987-11-03 Pandex Laboratories, Inc. Assay cartridge
US4948442A (en) * 1985-06-18 1990-08-14 Polyfiltronics, Inc. Method of making a multiwell test plate
US5047215A (en) * 1985-06-18 1991-09-10 Polyfiltronics, Inc. Multiwell test plate
US5108703A (en) * 1986-03-26 1992-04-28 Beckman Instruments, Inc. Automated multi-purpose analytical chemistry processing center and laboratory work station
USD297602S (en) * 1986-10-28 1988-09-13 Metrokane Imports, Inc. Lunchbox
US5110556A (en) * 1986-10-28 1992-05-05 Costar Corporation Multi-well test plate
US4948564A (en) * 1986-10-28 1990-08-14 Costar Corporation Multi-well filter strip and composite assemblies
SE454771B (en) * 1986-11-19 1988-05-30 Sprinter System Ab DEVICE FOR CLOSING A FLANGE SUPPLY, FILLED CARTRIDGE
DE3879209D1 (en) 1987-08-27 1993-04-15 Polyfiltronics Ltd FILTER UNITS FOR THE PREPARATION OF BIOLOGICAL SAMPLES.
US4902481A (en) * 1987-12-11 1990-02-20 Millipore Corporation Multi-well filtration test apparatus
US5108704A (en) * 1988-09-16 1992-04-28 W. R. Grace & Co.-Conn. Microfiltration apparatus with radially spaced nozzles
US5002889A (en) 1988-10-21 1991-03-26 Genetic Systems Corporation Reaction well shape for a microwell tray
US4927604A (en) * 1988-12-05 1990-05-22 Costar Corporation Multiwell filter plate vacuum manifold assembly
US5352086A (en) * 1990-01-27 1994-10-04 Georg Speiss Gmbh Apparatus for lifting sheets from a stack
US5114681A (en) * 1990-03-09 1992-05-19 Biomedical Research And Development Laboratories, Inc. Superfusion apparatus
DE4022792A1 (en) * 1990-07-18 1992-02-06 Max Planck Gesellschaft PLATE WITH AT LEAST ONE RECESS FOR RECEIVING CHEMICAL AND / OR BIOCHEMICAL AND / OR MICROBIOLOGICAL SUBSTANCES AND METHOD FOR PRODUCING THE PLATE
US5141719A (en) * 1990-07-18 1992-08-25 Bio-Rad Laboratories, Inc. Multi-sample filtration plate assembly
US5582665A (en) 1990-07-18 1996-12-10 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Process for sealing at least one well out of a number of wells provided in a plate for receiving chemical and/or biochemical and/or microbiological substances, and installation for carrying out the process
US5409832A (en) * 1990-08-29 1995-04-25 Stratecon Diagnostics International Membrane holder for use in an assay device
US5227290A (en) * 1990-08-29 1993-07-13 Pocock Douglas A Method for conducting diagnostic assays
US5308437A (en) * 1990-10-31 1994-05-03 Sumitomo Rubber Industries Ltd. Band member forming apparatus
US5282543A (en) * 1990-11-29 1994-02-01 The Perkin Elmer Corporation Cover for array of reaction tubes
KR100236506B1 (en) 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 Apparatus for polymerase chain reaction
US5525302A (en) * 1991-02-01 1996-06-11 Astle; Thomas W. Method and device for simultaneously transferring plural samples
DE4107262A1 (en) * 1991-03-07 1992-09-10 Eppendorf Geraetebau Netheler SUCTION DEVICE FOR MEMBRANE MICROTITER PLATES
US5264184A (en) * 1991-03-19 1993-11-23 Minnesota Mining And Manufacturing Company Device and a method for separating liquid samples
US5116496A (en) * 1991-03-19 1992-05-26 Minnesota Mining And Manufacturing Company Membrane-containing wells for microtitration and microfiltration
US5227137A (en) * 1991-04-04 1993-07-13 Nicholson Precision Instruments Inc. Vacuum clamped multi-sample filtration apparatus
US5650323A (en) * 1991-06-26 1997-07-22 Costar Corporation System for growing and manipulating tissue cultures using 96-well format equipment
US5205989A (en) * 1991-09-18 1993-04-27 Minnesota Mining And Manufacturing Company Multi-well filtration apparatus
US5384024A (en) 1992-03-13 1995-01-24 Applied Biosystems, Inc. Capillary electrophoresis
US5326533A (en) * 1992-11-04 1994-07-05 Millipore Corporation Multiwell test apparatus
US5380437A (en) * 1993-02-02 1995-01-10 Biomedical Research And Development Laboratories, Inc. Multifunctional filtration apparatus
US5459300A (en) 1993-03-03 1995-10-17 Kasman; David H. Microplate heater for providing uniform heating regardless of the geometry of the microplates
US6258325B1 (en) * 1993-04-19 2001-07-10 Ashok Ramesh Sanadi Method and apparatus for preventing cross-contamination of multi-well test plates
US5342581A (en) * 1993-04-19 1994-08-30 Sanadi Ashok R Apparatus for preventing cross-contamination of multi-well test plates
GB9311276D0 (en) * 1993-06-01 1993-07-21 Whatman Scient Limited Well inserts for use in tissue culture
US5368729A (en) * 1993-07-23 1994-11-29 Whatman, Inc. Solid phase extraction device
US5961926A (en) * 1993-09-27 1999-10-05 Packard Instrument Co., Inc. Microplate assembly and method of preparing samples for analysis in a microplate assembly
US5427265A (en) * 1993-10-22 1995-06-27 Dart Industries Inc. Lunchbox with safety lock
DE4412286A1 (en) * 1994-04-09 1995-10-12 Boehringer Mannheim Gmbh System for contamination-free processing of reaction processes
JP2909216B2 (en) * 1994-04-29 1999-06-23 パーキン‐エルマー コーポレイション Real-time detection device for nucleic acid amplification products
US5721136A (en) * 1994-11-09 1998-02-24 Mj Research, Inc. Sealing device for thermal cycling vessels
JPH08196299A (en) * 1995-01-26 1996-08-06 Tosoh Corp Thermal cycling reaction apparatus and reaction vessel therefor
US5846493A (en) * 1995-02-14 1998-12-08 Promega Corporation System for analyzing a substance from a solution following filtering of the substance from the solution
BE1010984A3 (en) 1995-02-17 1999-03-02 Praet Peter Van INCUBATOR FOR microtiter plate.
US5603900A (en) * 1995-05-19 1997-02-18 Millipore Investment Holdings Limited Vacuum filter device
US5604130A (en) * 1995-05-31 1997-02-18 Chiron Corporation Releasable multiwell plate cover
US5679310A (en) * 1995-07-11 1997-10-21 Polyfiltronics, Inc. High surface area multiwell test plate
US5792430A (en) 1996-08-12 1998-08-11 Monsanto Company Solid phase organic synthesis device with pressure-regulated manifold
US5665247A (en) * 1996-09-16 1997-09-09 Whatman Inc. Process for sealing microplates utilizing a thin polymeric film
DE19652327C2 (en) * 1996-12-16 2002-04-04 Europ Lab Molekularbiolog Method and device for carrying out chemical reaction sequences
US5961925A (en) 1997-09-22 1999-10-05 Bristol-Myers Squibb Company Apparatus for synthesis of multiple organic compounds with pinch valve block
EP0925828B1 (en) 1997-12-17 2004-09-29 Europäisches Laboratorium Für Molekularbiologie (Embl) Device for carrying out sequential chemical reactions
DE29722473U1 (en) * 1997-12-19 1998-02-19 Macherey Nagel Gmbh & Co Hg Separation device for the separation of substances
US6251343B1 (en) * 1998-02-24 2001-06-26 Caliper Technologies Corp. Microfluidic devices and systems incorporating cover layers
US6159368A (en) 1998-10-29 2000-12-12 The Perkin-Elmer Corporation Multi-well microfiltration apparatus

Also Published As

Publication number Publication date
US6451261B1 (en) 2002-09-17
DE69913978T2 (en) 2004-12-23
US6159368A (en) 2000-12-12
US6783732B2 (en) 2004-08-31
US20020179520A1 (en) 2002-12-05
US20030215956A1 (en) 2003-11-20
JP3725029B2 (en) 2005-12-07
WO2000025922A2 (en) 2000-05-11
US6506343B1 (en) 2003-01-14
JP2004354393A (en) 2004-12-16
AU756147B2 (en) 2003-01-02
EP1336433A1 (en) 2003-08-20
ES2212652T3 (en) 2004-07-16
CA2346860C (en) 2005-01-04
WO2000025922A3 (en) 2000-10-19
EP1124637A2 (en) 2001-08-22
ATE257036T1 (en) 2004-01-15
JP2007263966A (en) 2007-10-11
DE69913978D1 (en) 2004-02-05
EP1124637B1 (en) 2004-01-02
JP2002528265A (en) 2002-09-03
AU1518400A (en) 2000-05-22
US6338802B1 (en) 2002-01-15

Similar Documents

Publication Publication Date Title
CA2346860A1 (en) Multi-well microfiltration apparatus
US8007743B2 (en) Multifunctional vacuum manifold
US8926817B2 (en) Programmable electrophoretic notch filter systems and methods
US5560811A (en) Capillary electrophoresis apparatus and method
US7273759B2 (en) Plate alignment and sample transfer indicia for a multiwell multiplate stack and method for processing biological/chemical samples using the same
KR100923482B1 (en) Well for processing a fluid
DE60317603T2 (en) Microplate with protective base plate
CA2306791A1 (en) A multichannel microscale system for high throughput preparative separation with comprehensive collection and analysis
CA2294040A1 (en) Retentate chromatography and protein chip arrays with applications in biology and medicine
US6939452B2 (en) Parallel sample loading and injection device for multichannel microfluidic devices
EP1724019B1 (en) Receiver plate with multiple cross-sections
Sturm et al. Novel membrane devices and their potential utility in blood sample collection prior to analysis of dried plasma spots
WO2005114145A3 (en) Devices and methods to immobilize analytes of interest
DE102010041579A1 (en) Microfluidic unit with separation columns
WO1995001559A2 (en) Sample holder and its use
CA2043633A1 (en) Multi-sample filtration plate assembly
US20090081083A1 (en) Anti-clogging device and method for in-gel digestion applications
JP4794582B2 (en) Multifunctional vacuum manifold
US6685811B1 (en) Method for separation of macromolecules
US20030226796A1 (en) Modular system for separating components of a liquid sample
EP1286771A1 (en) Microhybridisation chamber
DE10018788A1 (en) Preparation of small protein samples for mass-spectroscopic analysis comprises enzymatic digestion of protein-containing gel pieces in vessels with lyophobic porous bottoms
EP3079821B1 (en) Circular extractor
EP1387390A3 (en) Retentate chromatography and protein chip arrays with applications in biology and medicine

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed