CA2357732A1 - Raman optrode processes and devices for detection of chemicals and microorganisms - Google Patents

Raman optrode processes and devices for detection of chemicals and microorganisms Download PDF

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Publication number
CA2357732A1
CA2357732A1 CA002357732A CA2357732A CA2357732A1 CA 2357732 A1 CA2357732 A1 CA 2357732A1 CA 002357732 A CA002357732 A CA 002357732A CA 2357732 A CA2357732 A CA 2357732A CA 2357732 A1 CA2357732 A1 CA 2357732A1
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CA
Canada
Prior art keywords
bioconcentrator
analytes
raman
analyte
electrical signal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002357732A
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French (fr)
Other versions
CA2357732C (en
Inventor
Ann E. Grow
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Individual
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US08/864,015 priority Critical patent/US5866430A/en
Priority to AU25584/99A priority patent/AU2558499A/en
Priority to PCT/US1999/000600 priority patent/WO2000043754A1/en
Priority to EP99905428A priority patent/EP1159603A4/en
Priority to CA002357732A priority patent/CA2357732C/en
Application filed by Individual filed Critical Individual
Priority to JP2000595128A priority patent/JP3704473B2/en
Priority to EP05000532A priority patent/EP1533607A3/en
Priority to CA002575023A priority patent/CA2575023A1/en
Publication of CA2357732A1 publication Critical patent/CA2357732A1/en
Application granted granted Critical
Publication of CA2357732C publication Critical patent/CA2357732C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00009—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with a sample supporting tape, e.g. with absorbent zones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/405—Concentrating samples by adsorption or absorption
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G01N2021/655—Stimulated Raman
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G01N2021/656—Raman microprobe
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons

Abstract

A methodology and devices for detecting or monitoring or identifying chemical or microbial analytes are described. The methodology comprises four basic steps: (1) The gas or liquid medium to be monitored or analyzed is brought into contact with a bioconcentrator which is used to bind with or collect and concentrate one or more analytes; (2) the bioconcentrator-analyte complex is then exposed to radiation of one or more predetermined wavelengths to produce Raman scattering spectral bands; (3) at least a portion of the Raman spectral bands are collected and processed by a Raman spectrometer to convert the same into an electrical signal; and (4) the electrical signal is processed to detect and identity, qualitatively and/or quantitatively, the analyte(s). The methodology of this invention may also comprise Raman reactive capacity analysis of the bioconcentrator itself, simultaneously with or independently from the detection of the analyte, to determine the potential ability of the bioconcentrator to complex with analytes; the results of this latter analysis may be used to affect or alter or modify the methodology involved in detection and analysis of the analytes. Also the invention is accomplished by a Raman Optrode comprising:
a bioconcentrator capable of binding with the analyte(s); a mechanism or procedure or device for bringing the gas or liquid sample into contact with the bioconcentrator, a light source suitable for generating Raman scattering; a Raman spectrometer capable of collecting and processing the Raman scattering spectral information and translating it into an electrical signal; and electronic hardware and software for analyzing the electrical signal and translating the signal into information on the presence, identity and/or quantity of the bound analytes.
Various forms of bioconcentrators are described, as well as a variety of analytes which may be detected, monitored, or identified by this invention, and a variety of devices which can be fabricated based on this invention.
CA002357732A 1996-06-13 1999-01-11 Raman optrode processes and devices for detection of chemicals and microorganisms Expired - Fee Related CA2357732C (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US08/864,015 US5866430A (en) 1996-06-13 1997-05-27 Raman optrode processes and devices for detection of chemicals and microorganisms
PCT/US1999/000600 WO2000043754A1 (en) 1996-06-13 1999-01-11 Raman optrode processes and devices for detection of chemicals and microorganisms
EP99905428A EP1159603A4 (en) 1996-06-13 1999-01-11 Raman optrode processes and devices for detection of chemicals and microorganisms
CA002357732A CA2357732C (en) 1996-06-13 1999-01-11 Raman optrode processes and devices for detection of chemicals and microorganisms
AU25584/99A AU2558499A (en) 1996-06-13 1999-01-11 Raman optrode processes and devices for detection of chemicals and microorganisms
JP2000595128A JP3704473B2 (en) 1996-06-13 1999-01-11 Raman optrode process and equipment for chemical and microbial detection
EP05000532A EP1533607A3 (en) 1996-06-13 1999-01-11 Method for identifying and monitoring analytes by Raman spectrometry
CA002575023A CA2575023A1 (en) 1996-06-13 1999-01-11 Raman optrode processes and devices for detection of chemicals and microorganisms

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1974296P 1996-06-13 1996-06-13
PCT/US1999/000600 WO2000043754A1 (en) 1996-06-13 1999-01-11 Raman optrode processes and devices for detection of chemicals and microorganisms
CA002357732A CA2357732C (en) 1996-06-13 1999-01-11 Raman optrode processes and devices for detection of chemicals and microorganisms

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002575023A Division CA2575023A1 (en) 1996-06-13 1999-01-11 Raman optrode processes and devices for detection of chemicals and microorganisms

Publications (2)

Publication Number Publication Date
CA2357732A1 true CA2357732A1 (en) 2000-07-27
CA2357732C CA2357732C (en) 2007-09-25

Family

ID=38740272

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002575023A Abandoned CA2575023A1 (en) 1996-06-13 1999-01-11 Raman optrode processes and devices for detection of chemicals and microorganisms
CA002357732A Expired - Fee Related CA2357732C (en) 1996-06-13 1999-01-11 Raman optrode processes and devices for detection of chemicals and microorganisms

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002575023A Abandoned CA2575023A1 (en) 1996-06-13 1999-01-11 Raman optrode processes and devices for detection of chemicals and microorganisms

Country Status (6)

Country Link
US (1) US5866430A (en)
EP (2) EP1533607A3 (en)
JP (1) JP3704473B2 (en)
AU (1) AU2558499A (en)
CA (2) CA2575023A1 (en)
WO (1) WO2000043754A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104007097A (en) * 2014-04-23 2014-08-27 厦门大学 Raman spectrometer in wireless interconnection with bluetooth intelligent terminal equipment

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