CA2368470A1 - Medical devices and applications of polyhydroxyalkanoate polymers - Google Patents

Medical devices and applications of polyhydroxyalkanoate polymers Download PDF

Info

Publication number
CA2368470A1
CA2368470A1 CA002368470A CA2368470A CA2368470A1 CA 2368470 A1 CA2368470 A1 CA 2368470A1 CA 002368470 A CA002368470 A CA 002368470A CA 2368470 A CA2368470 A CA 2368470A CA 2368470 A1 CA2368470 A1 CA 2368470A1
Authority
CA
Canada
Prior art keywords
composition
bone
group
devices
polyhydroxyalkanoate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002368470A
Other languages
French (fr)
Other versions
CA2368470C (en
Inventor
Simon F. Williams
David P. Martin
Frank Skraly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Metabolix Inc
Original Assignee
Metabolix, Inc.
Simon F. Williams
David P. Martin
Frank Skraly
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolix, Inc., Simon F. Williams, David P. Martin, Frank Skraly filed Critical Metabolix, Inc.
Publication of CA2368470A1 publication Critical patent/CA2368470A1/en
Application granted granted Critical
Publication of CA2368470C publication Critical patent/CA2368470C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/26—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
    • C08K5/0033—Additives activating the degradation of the macromolecular compound
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2201/00—Foams characterised by the foaming process
    • C08J2201/04—Foams characterised by the foaming process characterised by the elimination of a liquid or solid component, e.g. precipitation, leaching out, evaporation
    • C08J2201/044—Elimination of an inorganic solid phase
    • C08J2201/0444—Salts
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2201/00—Foams characterised by the foaming process
    • C08J2201/04—Foams characterised by the foaming process characterised by the elimination of a liquid or solid component, e.g. precipitation, leaching out, evaporation
    • C08J2201/048—Elimination of a frozen liquid phase
    • C08J2201/0482—Elimination of a frozen liquid phase the liquid phase being organic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
    • C08J2367/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S606/00—Surgery
    • Y10S606/907—Composed of particular material or coated
    • Y10S606/911—Memory material

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Polymers & Plastics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Materials For Medical Uses (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Prostheses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Devices formed of or including biocompatible polyhydroxylkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating system, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

Claims (34)

We claim:
1. A biodegradable polyhydroxyalkanoate composition having a controlled degradation rate of less than two years, preferably less than one year, by hydrolysis in vivo, selected from the group consisting of polyhydroxyalkanoate compositions wherein units are incorporated into the polymer backbone which alter the chemical stability of the polymer, wherein linkages are incorporated into the polymer backbone which alter the chemical stability of the polymer, wherein pendant groups are incorporated into the polymer which alter the chemical stability of the polymer, wherein biocompatible excipients altering degradation rates are incorporated into the composition, and wherein the porosity or exposed surface area of the polyhydroxyalkanoate compositions is increased in an amount effective to yield a composition degrading in vivo in less than two years.
2. The composition of claim 1 wherein the degradation rate of the polyhydroxyalkanoate composition is controlled by increasing the porosity of the polyhydroxyalkanoate composition.
3. The composition of claim 1 wherein the polyhydroxyalkanoate composition comprise additives selected from the group consisting of hydrophilic substances, hydrophobic substances, and coating which alter water uptake by the composition.
4. The composition of claim 1 wherein the degradation rate of the polyhydroxyalkanoate composition is increased by incorporation of a polymer selected from the group of consisting of poly-4-hydroxybutyrate, poly-4-hydroxybutyrate-co-3-hydroxybutyrate, poly-4-hydroxybutyrate-co-2-hydroxybutyrate, and copolymers and blends thereof.
5. The composition of claim 1 wherein the polyhydroxyalkanoate composition comprises a polymer selected from the group consisting of poly-3-hydroxybutyrate-co-3-hydroxyhexanoate, poly-3-hydroxybutyrate-co-3-hydroxyoctanoate, poly-3-hydroxybutryrate-co-3-hydroxydecanoate, and copolymers and blends thereof.
6. The composition of claim 4 wherein the polyhydroxyalkanoate composition comprises one or more units which alter the chemical stability of the polymer backbone.
7. The composition of claim 1 wherein the unit(s) promotes chain scission.
8. The composition of claim 1 wherein the units contain more than two functional groups.
9. The composition of claim 1 wherein the unit comprises a heteroatom grouping.
10. The composition of claim 9 wherein the heteroatom grouping comprises an atom selected from the group consisting of oxygen, sulfur and nitrogen.
11. The composition of claim 7 wherein the units are incorporated into the polymer backbone with chemical linkages selected from the group consisting of ester, amide, ether, carbamate, anhydride, and carbonate.
12. The composition of claim 11 wherein the units are selected from the group consisting of 2-hydroxyacids, 2-hydroxyalkoxyacetic acids, amino acids, amino alcohols, diacids, triols, and tetraols.
13. The composition of claim 12 wherein the 2-hydroxyacids are 2-hydroxyalkanoic acids.
l4. The composition of claim 13 wherein the Z-hydroxyalkanoic acid is lactic acid or glycolic acid.
15. The composition of claim 12 wherein the 2-hydroxyacids are 2-hydroxyalkenoic acids.
16. The composition of claim 12 wherein the 2-hydroxyallcoxyacetic acids are selected from the group consisting of 2-hydroxyethoxy acetic acid and 3-hydroxypropoxy acetic acid.
17. The composition of claim 1 wherein the pendent groups catalyze the degradation of the polymer backbone.
18. The composition of claim 17 wherein the pendant groups are selected from acidic and basic groups.
19. The composition of claim 1 wherein the pendant groups cause polymer chain scission.
20. The composition of claim 19 wherein the reactant pendant groups are selected from nucleophiles and electrophiles.
21. The composition of claim 17 wherein the pendant groups are selected from the group consisting of alcohols, acids, and amine groups.
22. The composition of claim I comprising additives altering the chemical stability of the polyhydroxyalkanoate composition.
23. The composition of claim 22 wherein the additives promote chain scission.
24. The composition of claim 22 wherein the additives are selected from the group consisting of acids, bases, electrophiles, nucleophiles, plasticizers, polymers, pore forming agents, and agents designed to reduce thepolymer crystallinity.
25. The composition of claim 1 comprising pore forming agents.
26. The composition of claim 25 wherein the pore forming agents are lyophilizable particles.
27. The composition of claim 25 wherein the pore forming agents absorb water.
28. The composition of claim 1 further comprising one or more active agents.
29. The composition of claim 28 wherein the active agent is selected from the group consisting of growth factors, alginates, silver salts, antiseptics, analgesics, and preservatives.
30. A device comprising a biodegradable polyhydroxyallcanoate composition that has a controlled degradation rate of less than two years, preferably less than one year, by hydrolysis in vivo, wherein the polyhydroxyalkanoate composition is selected from the group consisting of polyhydroxyalkanoate compositions wherein units are incorporated into the polymer backbone which alter the chemical stability of the polymer, wherein linkages are incorporated into the polymer backbone which alter the chemical stability of the polymer, wherein pendant groups are incorporated into the polymer which alter the chemical stability of the polymer, wherein biocompatible excipients altering degradation rates are incorporated into the composition, and wherein the porosity or exposed surface area of the polyhydroxyalkanoate compositions is increased in an amount effective to yield a composition degrading in vivo in less than two years; and wherein the device is selected from the group consisting of sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws, bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins, adhesion barriers, scents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents;wein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, ducal substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats.
31. A method for making a device that has a controlled degradation rate of less than two years, preferably less than one year by hydrolysis in vivo, comprising providing a biocompatible polyhydroxyallcanoate composition, as defined by any of claims 1-29; and forming or incorporating the polyhydroxyallcanoate composition into a device selected from the group consisting of sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws, bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins, adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, heart valves and vascular grafts, wound dressings, and hemostats.
32. The method of claim 31 wherein the forming process or incorporating process is selected from the group consisting of solvent casting, melt processing, fiber processing, fiber spinning, fiber weaving, extrusion, injection molding, compression molding, lamination, and microparticle formation.
33. The method of claim 31 further comprising incorporating an active agent into the polyhydroxyalkanoate composition.
34. A method of providing enhancing the healing of a wound, injury, or defect in a site in a patient, comprising administering at the site a device comprising a biocompatible polyhydroxyalkanoate composition as defined by any of claims 1-29, wherein the device is selected from the group consisting of sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws, bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins, adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, ligament and tendon grafts, ocular cell implants, spinal fusion cages, heart valves, vascular grafts, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats.
CA2368470A 1999-03-25 2000-03-24 Medical devices and applications of polyhydroxyalkanoate polymers Expired - Lifetime CA2368470C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12618099P 1999-03-25 1999-03-25
US60/126,180 1999-03-25
US14223899P 1999-07-02 1999-07-02
US60/142,238 1999-07-02
PCT/US2000/007890 WO2000056376A1 (en) 1999-03-25 2000-03-24 Medical devices and applications of polyhydroxyalkanoate polymers

Publications (2)

Publication Number Publication Date
CA2368470A1 true CA2368470A1 (en) 2000-09-28
CA2368470C CA2368470C (en) 2011-05-17

Family

ID=26824368

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2368470A Expired - Lifetime CA2368470C (en) 1999-03-25 2000-03-24 Medical devices and applications of polyhydroxyalkanoate polymers

Country Status (12)

Country Link
US (7) US6548569B1 (en)
EP (3) EP2305324B1 (en)
JP (1) JP5031144B2 (en)
AT (1) ATE376433T1 (en)
AU (1) AU778081B2 (en)
CA (1) CA2368470C (en)
CY (1) CY1107044T1 (en)
DE (1) DE60036863T2 (en)
DK (1) DK1163019T3 (en)
ES (3) ES2395057T3 (en)
PT (1) PT1163019E (en)
WO (1) WO2000056376A1 (en)

Families Citing this family (948)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8795332B2 (en) 2002-09-30 2014-08-05 Ethicon, Inc. Barbed sutures
US6241747B1 (en) * 1993-05-03 2001-06-05 Quill Medical, Inc. Barbed Bodily tissue connector
CA2178541C (en) * 1995-06-07 2009-11-24 Neal E. Fearnot Implantable medical device
US8556983B2 (en) 2001-05-25 2013-10-15 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs and related tools
US8480754B2 (en) 2001-05-25 2013-07-09 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8882847B2 (en) 2001-05-25 2014-11-11 Conformis, Inc. Patient selectable knee joint arthroplasty devices
US7534263B2 (en) 2001-05-25 2009-05-19 Conformis, Inc. Surgical tools facilitating increased accuracy, speed and simplicity in performing joint arthroplasty
US7468075B2 (en) 2001-05-25 2008-12-23 Conformis, Inc. Methods and compositions for articular repair
US8735773B2 (en) 2007-02-14 2014-05-27 Conformis, Inc. Implant device and method for manufacture
US8617242B2 (en) 2001-05-25 2013-12-31 Conformis, Inc. Implant device and method for manufacture
US9603711B2 (en) 2001-05-25 2017-03-28 Conformis, Inc. Patient-adapted and improved articular implants, designs and related guide tools
US8545569B2 (en) 2001-05-25 2013-10-01 Conformis, Inc. Patient selectable knee arthroplasty devices
US8083745B2 (en) 2001-05-25 2011-12-27 Conformis, Inc. Surgical tools for arthroplasty
US8771365B2 (en) 2009-02-25 2014-07-08 Conformis, Inc. Patient-adapted and improved orthopedic implants, designs, and related tools
US5931855A (en) 1997-05-21 1999-08-03 Frank Hoffman Surgical methods using one-way suture
US6828357B1 (en) * 1997-07-31 2004-12-07 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
US6306166B1 (en) * 1997-08-13 2001-10-23 Scimed Life Systems, Inc. Loading and release of water-insoluble drugs
WO1999023161A2 (en) * 1997-10-31 1999-05-14 Monsanto Company Polymer blends containing polyhydroxyalkanoates and compositions with good retention of elongation
WO1999055396A1 (en) * 1998-04-27 1999-11-04 Surmodics, Inc. Bioactive agent release coating
US20020188037A1 (en) * 1999-04-15 2002-12-12 Chudzik Stephen J. Method and system for providing bioactive agent release coating
MXPA01001111A (en) 1998-08-04 2002-04-24 Metabolix Inc Polyhydroxyalkanoate production from polyols.
US9289153B2 (en) * 1998-09-14 2016-03-22 The Board Of Trustees Of The Leland Stanford Junior University Joint and cartilage diagnosis, assessment and modeling
US7239908B1 (en) 1998-09-14 2007-07-03 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and devising treatment
EP1139872B1 (en) 1998-09-14 2009-08-19 The Board of Trustees of The Leland Stanford Junior University Assessing the condition of a joint and preventing damage
WO2000056376A1 (en) * 1999-03-25 2000-09-28 Metabolix, Inc. Medical devices and applications of polyhydroxyalkanoate polymers
US6179840B1 (en) 1999-07-23 2001-01-30 Ethicon, Inc. Graft fixation device and method
US20020095157A1 (en) 1999-07-23 2002-07-18 Bowman Steven M. Graft fixation device combination
JP2003509128A (en) * 1999-09-14 2003-03-11 テファ， インコーポレイテッド Polyhydroxyalkanoate compositions for soft tissue repair, augmentation and viscosupplementation
US7025980B1 (en) 1999-09-14 2006-04-11 Tepha, Inc. Polyhydroxyalkanoate compositions for soft tissue repair, augmentation, and viscosupplementation
US6786910B2 (en) * 1999-12-09 2004-09-07 Medtronic Ps Medical, Inc. Completely resorbable connective tissue distraction devices and techniques
EP1253857B1 (en) * 2000-02-03 2009-01-21 Tissuemed Limited Device for the closure of a surgical puncture
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US20160287708A9 (en) * 2000-03-15 2016-10-06 Orbusneich Medical, Inc. Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device
US20050271701A1 (en) * 2000-03-15 2005-12-08 Orbus Medical Technologies, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US8460367B2 (en) 2000-03-15 2013-06-11 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
AU6738801A (en) * 2000-04-27 2001-11-07 Axel Haverich Individual venous valve prosthesis
JP2001309969A (en) * 2000-04-28 2001-11-06 Gunze Ltd Artificial dura mater
WO2002022014A1 (en) 2000-09-14 2002-03-21 The Board Of Trustees Of The Leland Stanford Junior University Assessing the condition of a joint and devising treatment
ATE414310T1 (en) 2000-09-14 2008-11-15 Univ Leland Stanford Junior METHOD FOR MANIPULATION OF MEDICAL IMAGES
CA2365376C (en) 2000-12-21 2006-03-28 Ethicon, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
DE10122128A1 (en) * 2001-04-27 2002-11-07 Inst Polymerforschung Dresden Absorbable patch implant, process for its production and use
US8439926B2 (en) 2001-05-25 2013-05-14 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
DE60239674D1 (en) 2001-05-25 2011-05-19 Conformis Inc METHOD AND COMPOSITIONS FOR REPAIRING THE SURFACE OF JOINTS
US7371403B2 (en) * 2002-06-14 2008-05-13 Providence Health System-Oregon Wound dressing and method for controlling severe, life-threatening bleeding
US7482503B2 (en) * 2001-06-14 2009-01-27 Providence Health System-Oregon Wound dressing and method for controlling severe, life-threatening bleeding
US8741335B2 (en) 2002-06-14 2014-06-03 Hemcon Medical Technologies, Inc. Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from hydrophilic polymer foam such as Chitosan
US20060004314A1 (en) * 2001-06-14 2006-01-05 Hemcon, Inc. Antimicrobial barriers, systems, and methods formed from hydrophilic polymer structures such as chistosan
US7056331B2 (en) * 2001-06-29 2006-06-06 Quill Medical, Inc. Suture method
KR100521526B1 (en) * 2001-07-10 2005-10-13 캐논 가부시끼가이샤 Particulate construct comprising polyhydroxyalkanoate and method for producing it
US6848152B2 (en) * 2001-08-31 2005-02-01 Quill Medical, Inc. Method of forming barbs on a suture and apparatus for performing same
US6648862B2 (en) 2001-11-20 2003-11-18 Spheric Products, Ltd. Personally portable vacuum desiccator
US7318833B2 (en) * 2001-12-19 2008-01-15 Nmt Medical, Inc. PFO closure device with flexible thrombogenic joint and improved dislodgement resistance
EP1467661A4 (en) * 2001-12-19 2008-11-05 Nmt Medical Inc Septal occluder and associated methods
US7220265B2 (en) * 2002-01-14 2007-05-22 Nmt Medical, Inc. Patent foramen ovale (PFO) closure method and device
WO2003070292A1 (en) * 2002-02-22 2003-08-28 Biomatera Inc. Biodegradable bone implant
US6774158B2 (en) * 2002-03-20 2004-08-10 E. I. Du Pont De Nemours And Company Processing of polyhydroxyalkanoates using a nucleant and a plasticizer
WO2003082076A2 (en) * 2002-03-25 2003-10-09 Nmt Medical, Inc. Patent foramen ovale (pfo) closure clips
ES2360613T3 (en) 2002-04-16 2011-06-07 Tyco Healthcare Group Lp SURGICAL STAPLER.
US8039237B2 (en) * 2002-05-10 2011-10-18 Metabolix, Inc. Bioabsorbable polymer containing 2-hydroxyacid monomers
AU2003228979A1 (en) 2002-05-10 2003-11-11 Tyco Healthcare Group, Lp Surgical stapling apparatus having a wound closure material applicator assembly
US8187326B2 (en) * 2002-05-22 2012-05-29 Advanced Technologies And Regenerative Medicine, Llc. Attachment of absorbable tissue scaffolds to fixation devices
JP2005528181A (en) 2002-06-05 2005-09-22 エヌエムティー メディカル インコーポレイテッド Patent foramen ovale (PFO) occlusion device with radial and circumferential supports
US8269058B2 (en) * 2002-06-14 2012-09-18 Hemcon Medical Technologies, Inc. Absorbable tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan
US20050137512A1 (en) * 2003-12-23 2005-06-23 Campbell Todd D. Wound dressing and method for controlling severe, life-threatening bleeding
ES2383252T3 (en) 2002-06-17 2012-06-19 Tyco Healthcare Group Lp Annular Support Structures
US20030232087A1 (en) * 2002-06-18 2003-12-18 Lawin Laurie R. Bioactive agent release coating with aromatic poly(meth)acrylates
US7097850B2 (en) * 2002-06-18 2006-08-29 Surmodics, Inc. Bioactive agent release coating and controlled humidity method
US6773450B2 (en) 2002-08-09 2004-08-10 Quill Medical, Inc. Suture anchor and method
ES2395053T3 (en) * 2002-09-12 2015-10-08 Metabolix, Inc. Production of polyhydroxyalkanoate by means of coenzyme A-dependent aldehyde dehydrogenase pathways
US20040088003A1 (en) 2002-09-30 2004-05-06 Leung Jeffrey C. Barbed suture in combination with surgical needle
US8100940B2 (en) 2002-09-30 2012-01-24 Quill Medical, Inc. Barb configurations for barbed sutures
JP2006501977A (en) 2002-10-07 2006-01-19 コンフォーミス・インコーポレイテッド Minimally invasive joint implant with a three-dimensional profile that conforms to the joint surface
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US7824701B2 (en) 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
WO2004037333A1 (en) 2002-10-25 2004-05-06 Nmt Medical, Inc. Expandable sheath tubing
CA2503349A1 (en) * 2002-11-06 2004-05-27 Nmt Medical, Inc. Medical devices utilizing modified shape memory alloy
US7796791B2 (en) 2002-11-07 2010-09-14 Conformis, Inc. Methods for determining meniscal size and shape and for devising treatment
CA2503666A1 (en) * 2002-12-09 2004-06-24 Nmt Medical, Inc. Septal closure devices
US8197837B2 (en) 2003-03-07 2012-06-12 Depuy Mitek, Inc. Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof
US7285576B2 (en) * 2003-03-12 2007-10-23 3M Innovative Properties Co. Absorbent polymer compositions, medical articles, and methods
US20040180093A1 (en) * 2003-03-12 2004-09-16 3M Innovative Properties Company Polymer compositions with bioactive agent, medical articles, and methods
EP1610829B1 (en) * 2003-04-04 2010-01-20 Tissuemed Limited Tissue-adhesive formulations
AU2004238229B2 (en) * 2003-05-08 2007-07-12 Tepha, Inc. Polyhydroxyalkanoate medical textiles and fibers
US7624487B2 (en) 2003-05-13 2009-12-01 Quill Medical, Inc. Apparatus and method for forming barbs on a suture
US9060770B2 (en) 2003-05-20 2015-06-23 Ethicon Endo-Surgery, Inc. Robotically-driven surgical instrument with E-beam driver
US20070084897A1 (en) 2003-05-20 2007-04-19 Shelton Frederick E Iv Articulating surgical stapling instrument incorporating a two-piece e-beam firing mechanism
US8226715B2 (en) 2003-06-30 2012-07-24 Depuy Mitek, Inc. Scaffold for connective tissue repair
SE0301974D0 (en) * 2003-07-03 2003-07-03 Astra Tech Ab A device for promoting regeneration of an injured nerve, a kit and a biodegradable sheet for preparing such a device
WO2005007195A1 (en) * 2003-07-08 2005-01-27 Tepha, Inc. Poly-4-hydroxybutyrate matrices for sustained drug delivery
US8480706B2 (en) 2003-07-14 2013-07-09 W.L. Gore & Associates, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
EP1651116B1 (en) 2003-07-14 2013-06-26 W.L. Gore & Associates, Inc. Tubular patent foramen ovale (pfo) closure device with catch system
US9861346B2 (en) 2003-07-14 2018-01-09 W. L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure device with linearly elongating petals
ES2537307T3 (en) * 2003-07-16 2015-06-05 Eidgenössische Technische Hochschule Zürich Biocompatible block copolymer, degradable
US10583220B2 (en) 2003-08-11 2020-03-10 DePuy Synthes Products, Inc. Method and apparatus for resurfacing an articular surface
DE602004023314D1 (en) 2003-08-14 2009-11-05 Boston Scient Ltd SURGICAL SLINGS
US8545386B2 (en) 2003-08-14 2013-10-01 Boston Scientific Scimed, Inc. Surgical slings
WO2005018728A2 (en) 2003-08-19 2005-03-03 Nmt Medical, Inc. Expandable sheath tubing
WO2005020825A1 (en) * 2003-08-22 2005-03-10 Tepha, Inc. Polyhydroxyalkanoate nerve regeneration devices
US20050065484A1 (en) * 2003-09-10 2005-03-24 Watson Richard L. Wound healing apparatus with bioabsorbable material and suction tubes
US7141354B2 (en) * 2003-09-30 2006-11-28 Dai Nippon Printing Co., Ltd. Photo radical generator, photo sensitive resin composition and article
US20050107867A1 (en) * 2003-11-17 2005-05-19 Taheri Syde A. Temporary absorbable venous occlusive stent and superficial vein treatment method
US9114198B2 (en) 2003-11-19 2015-08-25 Advanced Cardiovascular Systems, Inc. Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same
US7316822B2 (en) * 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US7901461B2 (en) * 2003-12-05 2011-03-08 Ethicon, Inc. Viable tissue repair implants and methods of use
US7745509B2 (en) 2003-12-05 2010-06-29 3M Innovative Properties Company Polymer compositions with bioactive agent, medical articles, and methods
US20050123590A1 (en) * 2003-12-05 2005-06-09 3M Innovative Properties Company Wound dressings and methods
US20050273119A1 (en) 2003-12-09 2005-12-08 Nmt Medical, Inc. Double spiral patent foramen ovale closure clamp
DE10361075A1 (en) * 2003-12-22 2005-07-28 Pac Tech - Packaging Technologies Gmbh Method and apparatus for drying circuit substrates
GB0329654D0 (en) 2003-12-23 2004-01-28 Smith & Nephew Tunable segmented polyacetal
US11395865B2 (en) 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US20050214345A1 (en) * 2004-02-20 2005-09-29 Theodore Leng Artificial biocompatible material as a support for cells in a retinal implant
US7871419B2 (en) * 2004-03-03 2011-01-18 Nmt Medical, Inc. Delivery/recovery system for septal occluder
US20050260275A1 (en) * 2004-04-01 2005-11-24 Procyte Corporation Encapsulated peptide copper complexes and compositions and methods related thereto
US7790945B1 (en) 2004-04-05 2010-09-07 Kci Licensing, Inc. Wound dressing with absorption and suction capabilities
US20060083772A1 (en) * 2004-04-06 2006-04-20 Dewitt David M Coating compositions for bioactive agents
WO2005099786A1 (en) * 2004-04-06 2005-10-27 Surmodics, Inc. Coating compositions for bioactive agents
US20050267524A1 (en) * 2004-04-09 2005-12-01 Nmt Medical, Inc. Split ends closure device
US8221780B2 (en) 2004-04-20 2012-07-17 Depuy Mitek, Inc. Nonwoven tissue scaffold
US8657881B2 (en) * 2004-04-20 2014-02-25 Depuy Mitek, Llc Meniscal repair scaffold
US8137686B2 (en) * 2004-04-20 2012-03-20 Depuy Mitek, Inc. Nonwoven tissue scaffold
WO2005104992A1 (en) * 2004-04-26 2005-11-10 Bioduct Llc Stent for avascular meniscal repair and regeneration
US8361110B2 (en) * 2004-04-26 2013-01-29 W.L. Gore & Associates, Inc. Heart-shaped PFO closure device
US20050288481A1 (en) 2004-04-30 2005-12-29 Desnoyer Jessica R Design of poly(ester amides) for the control of agent-release from polymeric compositions
US7820732B2 (en) * 2004-04-30 2010-10-26 Advanced Cardiovascular Systems, Inc. Methods for modulating thermal and mechanical properties of coatings on implantable devices
WO2005105164A1 (en) * 2004-04-30 2005-11-10 Sunstar Suisse Sa Biocompatible membrane and process for producing the same
US7842053B2 (en) 2004-05-06 2010-11-30 Nmt Medical, Inc. Double coil occluder
US8308760B2 (en) 2004-05-06 2012-11-13 W.L. Gore & Associates, Inc. Delivery systems and methods for PFO closure device with two anchors
US8257389B2 (en) 2004-05-07 2012-09-04 W.L. Gore & Associates, Inc. Catching mechanisms for tubular septal occluder
US7407511B2 (en) * 2004-05-13 2008-08-05 Wright Medical Technology Inc Methods and materials for connective tissue repair
EP2664282B1 (en) 2004-05-14 2017-06-21 Ethicon, LLC Suture devices
US8215531B2 (en) 2004-07-28 2012-07-10 Ethicon Endo-Surgery, Inc. Surgical stapling instrument having a medical substance dispenser
US11896225B2 (en) 2004-07-28 2024-02-13 Cilag Gmbh International Staple cartridge comprising a pan
PT1778305E (en) * 2004-08-03 2010-07-27 Tepha Inc Non-curling polyhydroxyalkanoate sutures
BRPI0514106A (en) 2004-08-03 2008-05-27 Tissuemed Ltd fabric adhesive materials
US20060052822A1 (en) * 2004-08-31 2006-03-09 Mirizzi Michael S Apparatus and material composition for permanent occlusion of a hollow anatomical structure
CN101065416B (en) * 2004-09-13 2011-04-13 梅塔博利克斯股份有限公司 Single solvent polymer extraction methods
EP1827247B8 (en) 2004-09-24 2020-05-06 W.L. Gore & Associates, Inc. Occluder device double securement system for delivery/recovery of such occluder device
AU2005295477B2 (en) 2004-10-18 2011-11-24 Covidien Lp Structure for applying sprayable wound treatment material
ES2539933T3 (en) 2004-10-18 2015-07-07 Covidien Lp Apparatus for applying material for the treatment of wounds using needles that penetrate the tissues
US7845536B2 (en) 2004-10-18 2010-12-07 Tyco Healthcare Group Lp Annular adhesive structure
AU2005295476B2 (en) 2004-10-18 2011-03-24 Covidien Lp Extraluminal sealant applicator and method
US7717313B2 (en) 2004-10-18 2010-05-18 Tyco Healthcare Group Lp Surgical apparatus and structure for applying sprayable wound treatment material
US7938307B2 (en) 2004-10-18 2011-05-10 Tyco Healthcare Group Lp Support structures and methods of using the same
US7455682B2 (en) 2004-10-18 2008-11-25 Tyco Healthcare Group Lp Structure containing wound treatment material
ATE424862T1 (en) * 2004-10-29 2009-03-15 Smith & Nephew Inc BIOABSORBABLE POLYMERS WITH CALCIUM CARBONATE
US8545866B2 (en) * 2004-10-29 2013-10-01 Smith & Nephew, Inc. Bioabsorbable polymers
US8021392B2 (en) * 2004-11-22 2011-09-20 Minsurg International, Inc. Methods and surgical kits for minimally-invasive facet joint fusion
US20060111786A1 (en) * 2004-11-22 2006-05-25 Orthopedic Development Corporation Metallic prosthetic implant for use in minimally invasive acromio-clavicular shoulder joint hemi-arthroplasty
US20060111779A1 (en) 2004-11-22 2006-05-25 Orthopedic Development Corporation, A Florida Corporation Minimally invasive facet joint fusion
US20060111780A1 (en) * 2004-11-22 2006-05-25 Orthopedic Development Corporation Minimally invasive facet joint hemi-arthroplasty
US20060147505A1 (en) * 2004-12-30 2006-07-06 Tanzer Richard W Water-dispersible wet wipe having mixed solvent wetting composition
US20060147689A1 (en) * 2004-12-30 2006-07-06 Raj Wallajapet Absorbent composites containing biodegradable reinforcing fibers
US8007775B2 (en) 2004-12-30 2011-08-30 Advanced Cardiovascular Systems, Inc. Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same
US7202325B2 (en) * 2005-01-14 2007-04-10 Advanced Cardiovascular Systems, Inc. Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles
BRPI0606423A2 (en) * 2005-01-19 2009-06-30 Nexgen Spine Llc surgical implant and its manufacturing method
CN102525591B (en) 2005-01-25 2014-12-10 泰科医疗集团有限合伙公司 Structures for permanent occlusion of a hollow anatomical structure
DE602006016915D1 (en) * 2005-01-28 2010-10-28 Tepha Inc EMBOLIZATION USING POLY-4-HYDROXYBUTYRATE PARTICLES
US7718109B2 (en) 2005-02-14 2010-05-18 Mayo Foundation For Medical Education And Research Tissue support structure
US9168328B2 (en) * 2005-02-25 2015-10-27 Drexel University Layered manufacturing utilizing foam as a support and multifunctional material for the creation of parts and for tissue engineering
US9204957B2 (en) * 2005-03-17 2015-12-08 Hemcon Medical Technologies, Inc. Systems and methods for hemorrhage control and or tissue repair
US8277480B2 (en) 2005-03-18 2012-10-02 W.L. Gore & Associates, Inc. Catch member for PFO occluder
US7981140B2 (en) * 2005-03-30 2011-07-19 Arthrex, Inc. Knotless fixation of tissue to bone with suture chain
US8778375B2 (en) 2005-04-29 2014-07-15 Advanced Cardiovascular Systems, Inc. Amorphous poly(D,L-lactide) coating
US20060271048A1 (en) * 2005-05-12 2006-11-30 Jeffery Thramann Pedicle screw based vertebral body stabilization apparatus
US7828830B2 (en) * 2005-05-12 2010-11-09 Lanx, Inc. Dynamic spinal stabilization
US20060271055A1 (en) * 2005-05-12 2006-11-30 Jeffery Thramann Spinal stabilization
US20060282084A1 (en) * 2005-06-03 2006-12-14 Ken Blier System and method for sealing tissue
CA2615058A1 (en) * 2005-07-13 2007-01-18 Hemcon, Inc. Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from chitosan and including a polymer mesh material of poly-4-hydroxy butyrate
US7669746B2 (en) 2005-08-31 2010-03-02 Ethicon Endo-Surgery, Inc. Staple cartridges for forming staples having differing formed staple heights
US10159482B2 (en) 2005-08-31 2018-12-25 Ethicon Llc Fastener cartridge assembly comprising a fixed anvil and different staple heights
US7934630B2 (en) 2005-08-31 2011-05-03 Ethicon Endo-Surgery, Inc. Staple cartridges for forming staples having differing formed staple heights
US11484312B2 (en) 2005-08-31 2022-11-01 Cilag Gmbh International Staple cartridge comprising a staple driver arrangement
US20070194082A1 (en) 2005-08-31 2007-08-23 Morgan Jerome R Surgical stapling device with anvil having staple forming pockets of varying depths
US11246590B2 (en) 2005-08-31 2022-02-15 Cilag Gmbh International Staple cartridge including staple drivers having different unfired heights
US9237891B2 (en) 2005-08-31 2016-01-19 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical stapling devices that produce formed staples having different lengths
ES2282025B1 (en) * 2005-09-08 2008-11-01 Universitat Politecnica De Catalunya PROCESS OF OBTAINING AND BIOMEDICAL APPLICATIONS OF ALTERNATE POLYESTERS CONSTITUTED BY UNITS OF 4-HYDROXIBUTRIC ACID AND ALIFATIC HYDROXIACIDES.
WO2007120186A2 (en) * 2005-10-24 2007-10-25 Nmt Medical, Inc. Radiopaque bioabsorbable occluder
US20110076255A1 (en) * 2005-11-07 2011-03-31 Pecora Andrew L Compositions and methods for treating progressive myocardial injury due to a vascular insufficiency
US20070106317A1 (en) 2005-11-09 2007-05-10 Shelton Frederick E Iv Hydraulically and electrically actuated articulation joints for surgical instruments
US20070196423A1 (en) * 2005-11-21 2007-08-23 Med Institute, Inc. Implantable medical device coatings with biodegradable elastomer and releasable therapeutic agent
US20070128243A1 (en) * 2005-12-02 2007-06-07 Xylos Corporation Implantable microbial cellulose materials for various medical applications
SI2347775T1 (en) 2005-12-13 2020-10-30 President And Fellows Of Harvard College Scaffolds for cell transplantation
US8690957B2 (en) 2005-12-21 2014-04-08 Warsaw Orthopedic, Inc. Bone graft composition, method and implant
EP1962695A1 (en) * 2005-12-22 2008-09-03 NMT Medical, Inc. Catch members for occluder devices
US11278279B2 (en) 2006-01-31 2022-03-22 Cilag Gmbh International Surgical instrument assembly
US8708213B2 (en) 2006-01-31 2014-04-29 Ethicon Endo-Surgery, Inc. Surgical instrument having a feedback system
US11224427B2 (en) 2006-01-31 2022-01-18 Cilag Gmbh International Surgical stapling system including a console and retraction assembly
US20110006101A1 (en) 2009-02-06 2011-01-13 EthiconEndo-Surgery, Inc. Motor driven surgical fastener device with cutting member lockout arrangements
US8820603B2 (en) 2006-01-31 2014-09-02 Ethicon Endo-Surgery, Inc. Accessing data stored in a memory of a surgical instrument
US7845537B2 (en) 2006-01-31 2010-12-07 Ethicon Endo-Surgery, Inc. Surgical instrument having recording capabilities
US11793518B2 (en) 2006-01-31 2023-10-24 Cilag Gmbh International Powered surgical instruments with firing system lockout arrangements
US7753904B2 (en) 2006-01-31 2010-07-13 Ethicon Endo-Surgery, Inc. Endoscopic surgical instrument with a handle that can articulate with respect to the shaft
US9861359B2 (en) 2006-01-31 2018-01-09 Ethicon Llc Powered surgical instruments with firing system lockout arrangements
US20120292367A1 (en) 2006-01-31 2012-11-22 Ethicon Endo-Surgery, Inc. Robotically-controlled end effector
US20110295295A1 (en) 2006-01-31 2011-12-01 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical instrument having recording capabilities
US8186555B2 (en) 2006-01-31 2012-05-29 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting and fastening instrument with mechanical closure system
US20110024477A1 (en) 2009-02-06 2011-02-03 Hall Steven G Driven Surgical Stapler Improvements
US8162974B2 (en) * 2006-02-02 2012-04-24 Boston Scientific Scimed, Inc. Occlusion apparatus, system, and method
AU2007210879B2 (en) * 2006-02-03 2013-01-10 Tissuemed Limited Tissue-adhesive materials
AU2007212033B2 (en) 2006-02-06 2014-01-23 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools
US8623026B2 (en) 2006-02-06 2014-01-07 Conformis, Inc. Patient selectable joint arthroplasty devices and surgical tools incorporating anatomical relief
WO2007092418A2 (en) * 2006-02-07 2007-08-16 Tepha, Inc. Polymeric, degradable drug-eluting stents and coatings
ES2624589T3 (en) * 2006-02-07 2017-07-17 Tepha, Inc. Methods and devices for rotator cuff repair
US9592325B2 (en) 2006-02-07 2017-03-14 Tepha, Inc. Polymeric, degradable drug-eluting stents and coatings
US8979921B2 (en) 2006-02-07 2015-03-17 Tepha, Inc. Polymeric, degradable drug-eluting stents and coatings
EP2114298B1 (en) 2006-02-08 2022-10-19 Medtronic, Inc. Temporarily stiffened mesh prostheses
US8591531B2 (en) * 2006-02-08 2013-11-26 Tyrx, Inc. Mesh pouches for implantable medical devices
US8315700B2 (en) * 2006-02-08 2012-11-20 Tyrx, Inc. Preventing biofilm formation on implantable medical devices
US7910152B2 (en) 2006-02-28 2011-03-22 Advanced Cardiovascular Systems, Inc. Poly(ester amide)-based drug delivery systems with controlled release rate and morphology
US20070233073A1 (en) * 2006-03-02 2007-10-04 Sdgi Holdings, Inc. Spinal rod characterized by a time-varying stiffness
US7709631B2 (en) 2006-03-13 2010-05-04 Xylos Corporation Oxidized microbial cellulose and use thereof
US8992422B2 (en) 2006-03-23 2015-03-31 Ethicon Endo-Surgery, Inc. Robotically-controlled endoscopic accessory channel
US20070225562A1 (en) 2006-03-23 2007-09-27 Ethicon Endo-Surgery, Inc. Articulating endoscopic accessory channel
JP2009532123A (en) * 2006-03-31 2009-09-10 エヌエムティー メディカル， インコーポレイティッド Variable length patent foramen ovale (PFO) occluder and catch system
US8551135B2 (en) * 2006-03-31 2013-10-08 W.L. Gore & Associates, Inc. Screw catch mechanism for PFO occluder and method of use
CA2647505C (en) * 2006-03-31 2014-07-29 Nmt Medical, Inc. Deformable flap catch mechanism for occluder device
US8870913B2 (en) 2006-03-31 2014-10-28 W.L. Gore & Associates, Inc. Catch system with locking cap for patent foramen ovale (PFO) occluder
US9017361B2 (en) * 2006-04-20 2015-04-28 Covidien Lp Occlusive implant and methods for hollow anatomical structure
US8221468B2 (en) * 2006-05-11 2012-07-17 Gaines Jr Robert W Use of bioabsorbable materials for anterior extradiscal correction of thoracolumbar pathologies
JP2009537660A (en) * 2006-05-15 2009-10-29 タイコ ヘルスケア グループ リミテッド パートナーシップ Furanone end cap polymer
CA2652030A1 (en) * 2006-05-15 2007-11-22 Tyco Healthcare Group Lp Furanone-initiated polymers
WO2007139845A2 (en) 2006-05-23 2007-12-06 Providence Health System-Oregon D/B/A Providence St. Vincent Medical Center Systems and methods for introducing and applying a bandage structure within a body lumen or hollow body organ
US20070286884A1 (en) * 2006-06-13 2007-12-13 Xylos Corporation Implantable microbial cellulose materials for hard tissue repair and regeneration
US8322455B2 (en) 2006-06-27 2012-12-04 Ethicon Endo-Surgery, Inc. Manually driven surgical cutting and fastening instrument
US9089627B2 (en) 2006-07-11 2015-07-28 Abbott Cardiovascular Systems Inc. Stent fabricated from polymer composite toughened by a dispersed phase
US20080033487A1 (en) * 2006-08-07 2008-02-07 Bioduct, Llc Medical device for repair of tissue and method for implantation and fixation
EP2051646A4 (en) * 2006-08-07 2014-06-11 Howmedica Osteonics Corp Insertion system for implanting a medical device and surgical methods
IL177550A0 (en) * 2006-08-17 2006-12-31 Sialo Technology Israel Ltd All-in-one optical microscopic handle
US20080065218A1 (en) * 2006-09-13 2008-03-13 O'neil Michael J Annulus fibrosus repair devices and techniques
WO2008039521A2 (en) * 2006-09-26 2008-04-03 Nmt Medical, Inc. Method for modifying a medical implant surface for promoting tissue growth
US20080077180A1 (en) * 2006-09-26 2008-03-27 Nmt Medical, Inc. Scaffold for tubular septal occluder device and techniques for attachment
US20080082083A1 (en) * 2006-09-28 2008-04-03 Forde Sean T Perforated expandable implant recovery sheath
US7506791B2 (en) 2006-09-29 2009-03-24 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with mechanical mechanism for limiting maximum tissue compression
US10130359B2 (en) 2006-09-29 2018-11-20 Ethicon Llc Method for forming a staple
US10568652B2 (en) 2006-09-29 2020-02-25 Ethicon Llc Surgical staples having attached drivers of different heights and stapling instruments for deploying the same
US20080172126A1 (en) * 2006-10-03 2008-07-17 Reynolds Martin A Nucleus pulposus injection devices and methods
US9066996B1 (en) 2006-10-13 2015-06-30 Hrl Laboratories, Llc Method to control the biodegradation rates of polymer structures
US20080103510A1 (en) * 2006-10-25 2008-05-01 Apogee Surgical Instruments Bio-absorbable tissue closure system
US20080103584A1 (en) * 2006-10-25 2008-05-01 Biosensors International Group Temporal Intraluminal Stent, Methods of Making and Using
AU2013200515C1 (en) * 2006-11-06 2016-09-22 Medtronic, Inc. Mesh pouches for implantable medical devices
US9023114B2 (en) * 2006-11-06 2015-05-05 Tyrx, Inc. Resorbable pouches for implantable medical devices
MX2009004821A (en) * 2006-11-06 2009-11-23 Tyrx Pharma Inc Mesh pouches for implantable medical devices.
MX2009004819A (en) * 2006-11-06 2009-11-23 Tyrx Pharma Inc Resorbable pouches for implantable medical devices.
US8740941B2 (en) 2006-11-10 2014-06-03 Lanx, Inc. Pedicle based spinal stabilization with adjacent vertebral body support
US9011439B2 (en) * 2006-11-20 2015-04-21 Poly-Med, Inc. Selectively absorbable/biodegradable, fibrous composite constructs and applications thereof
US8722783B2 (en) 2006-11-30 2014-05-13 Smith & Nephew, Inc. Fiber reinforced composite material
US20080132604A1 (en) * 2006-11-30 2008-06-05 Terumo Kabushiki Kaisha Poly-(alpha-hydroxy acid) composition and method of producing molded article using the same
US7943683B2 (en) * 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US8177798B2 (en) 2006-12-05 2012-05-15 Tyco Healthcare Group Lp Adhesive coated stent and insertion instrument
US20080145405A1 (en) * 2006-12-15 2008-06-19 Kunzler Jay F Drug delivery devices
US20080181928A1 (en) * 2006-12-22 2008-07-31 Miv Therapeutics, Inc. Coatings for implantable medical devices for liposome delivery
JP2008154844A (en) * 2006-12-25 2008-07-10 Gunze Ltd Suture reinforcement for automatic suture instrument
US8652120B2 (en) 2007-01-10 2014-02-18 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between control unit and sensor transponders
US8684253B2 (en) 2007-01-10 2014-04-01 Ethicon Endo-Surgery, Inc. Surgical instrument with wireless communication between a control unit of a robotic system and remote sensor
US11291441B2 (en) 2007-01-10 2022-04-05 Cilag Gmbh International Surgical instrument with wireless communication between control unit and remote sensor
US11039836B2 (en) 2007-01-11 2021-06-22 Cilag Gmbh International Staple cartridge for use with a surgical stapling instrument
US8701958B2 (en) 2007-01-11 2014-04-22 Ethicon Endo-Surgery, Inc. Curved end effector for a surgical stapling device
US8870871B2 (en) 2007-01-17 2014-10-28 University Of Massachusetts Lowell Biodegradable bone plates and bonding systems
ES2409759T3 (en) 2007-01-21 2013-06-27 Hemoteq Ag Medical product for the treatment of stenosis of the channels of the body and for the prevention of threatening stenosis
JP2010517638A (en) * 2007-02-02 2010-05-27 トアニエ， インコーポレイテッド Systems and methods for repairing tendons and ligaments
DE102007008479A1 (en) * 2007-02-21 2008-09-04 Orlowski, Michael, Dr. Coated Expandable System
US10278947B2 (en) 2007-02-28 2019-05-07 Orthopeutics, L.P. Crosslinker enhanced repair of connective tissues
US20090192530A1 (en) 2008-01-29 2009-07-30 Insightra Medical, Inc. Fortified mesh for tissue repair
US7669747B2 (en) 2007-03-15 2010-03-02 Ethicon Endo-Surgery, Inc. Washer for use with a surgical stapling instrument
ES2369417T3 (en) * 2007-03-23 2011-11-30 Stryker Trauma Gmbh DEVICE FOR IMPLEMENTATION, PROCEDURE FOR PRODUCTION AND FOR THE APPLICATION OF THE SAME.
US8893946B2 (en) 2007-03-28 2014-11-25 Ethicon Endo-Surgery, Inc. Laparoscopic tissue thickness and clamp load measuring devices
CA2682190C (en) * 2007-03-29 2015-01-27 Tyrx Pharma, Inc. Biodegradable, polymer coverings for breast implants
WO2008124603A1 (en) 2007-04-05 2008-10-16 Nmt Medical, Inc. Septal closure device with centering mechanism
US8915943B2 (en) * 2007-04-13 2014-12-23 Ethicon, Inc. Self-retaining systems for surgical procedures
US9138562B2 (en) 2007-04-18 2015-09-22 W.L. Gore & Associates, Inc. Flexible catheter system
AU2008240418B2 (en) 2007-04-18 2013-08-15 Smith & Nephew Plc Expansion moulding of shape memory polymers
EP2142227B1 (en) 2007-04-19 2012-02-29 Smith & Nephew, Inc. Multi-modal shape memory polymers
US9770534B2 (en) 2007-04-19 2017-09-26 Smith & Nephew, Inc. Graft fixation
AU2008242289A1 (en) * 2007-04-19 2008-10-30 Smith & Nephew, Inc. Shape memory polymers containing degradation accelerant
US8147769B1 (en) 2007-05-16 2012-04-03 Abbott Cardiovascular Systems Inc. Stent and delivery system with reduced chemical degradation
US11564682B2 (en) 2007-06-04 2023-01-31 Cilag Gmbh International Surgical stapler device
US8931682B2 (en) 2007-06-04 2015-01-13 Ethicon Endo-Surgery, Inc. Robotically-controlled shaft based rotary drive systems for surgical instruments
US8252361B2 (en) * 2007-06-05 2012-08-28 Abbott Cardiovascular Systems Inc. Implantable medical devices for local and regional treatment
US9770535B2 (en) * 2007-06-21 2017-09-26 President And Fellows Of Harvard College Scaffolds for cell collection or elimination
US8308040B2 (en) 2007-06-22 2012-11-13 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with an articulatable end effector
US7753245B2 (en) 2007-06-22 2010-07-13 Ethicon Endo-Surgery, Inc. Surgical stapling instruments
US11849941B2 (en) 2007-06-29 2023-12-26 Cilag Gmbh International Staple cartridge having staple cavities extending at a transverse angle relative to a longitudinal cartridge axis
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
ES2322008B1 (en) * 2007-07-19 2010-03-11 Universitat Politecnica De Catalunya PROCESS OF OBTAINING AND BIOMEDICAL APPLICATIONS OF ALTERNATE POLYESTERS CONSTITUTED BY UNITS OF GLYCOLIC ACID AND ALIFATIC HYDROXIACIDES.
GB0715514D0 (en) * 2007-08-10 2007-09-19 Tissuemed Ltd Coated medical devices
EP2550978B1 (en) * 2007-09-27 2014-04-30 Ethicon, LLC A system for cutting a retainer in a suture
US8715319B2 (en) * 2007-09-28 2014-05-06 W.L. Gore & Associates, Inc. Catch member for septal occluder with adjustable-length center joint
US20090099651A1 (en) * 2007-10-10 2009-04-16 Miv Therapeutics, Inc. Lipid coatings for implantable medical devices
EP2217289A2 (en) * 2007-10-31 2010-08-18 Angiotech Pharmaceuticals, Inc. Combining synthetic, natural polymers and recombinant polymers to form monofilament and multifilament self-retaining sutures
US20090112259A1 (en) * 2007-10-31 2009-04-30 Angiotech Pharmaceuticals, Inc. Recombinant expressed bioadsorbable polyhydroxyalkonate monofilament and multi-filaments self-retaining sutures
US20090143819A1 (en) * 2007-10-31 2009-06-04 D Agostino William L Coatings for modifying monofilament and multi-filaments self-retaining sutures
US8313527B2 (en) 2007-11-05 2012-11-20 Allergan, Inc. Soft prosthesis shell texturing method
US8916077B1 (en) 2007-12-19 2014-12-23 Ethicon, Inc. Self-retaining sutures with retainers formed from molten material
WO2009086172A2 (en) * 2007-12-19 2009-07-09 Angiotech Pharmaceuticals, Inc. Self-retaining sutures with heat-contact mediated retainers
US8287909B2 (en) * 2007-12-19 2012-10-16 Tepha, Inc. Medical devices containing melt-blown non-wovens of poly-4-hydroxybutyrate and copolymers thereof
US8118834B1 (en) 2007-12-20 2012-02-21 Angiotech Pharmaceuticals, Inc. Composite self-retaining sutures and method
US8875607B2 (en) 2008-01-30 2014-11-04 Ethicon, Inc. Apparatus and method for forming self-retaining sutures
US8615856B1 (en) 2008-01-30 2013-12-31 Ethicon, Inc. Apparatus and method for forming self-retaining sutures
EP2085054A1 (en) * 2008-02-01 2009-08-05 Technische Universiteit Eindhoven Method for manufacturing a tissue-engineered construct
US7905381B2 (en) 2008-09-19 2011-03-15 Ethicon Endo-Surgery, Inc. Surgical stapling instrument with cutting member arrangement
US9370558B2 (en) 2008-02-13 2016-06-21 President And Fellows Of Harvard College Controlled delivery of TLR agonists in structural polymeric devices
AU2009215188B2 (en) 2008-02-13 2014-09-18 Dana-Farber Cancer Institute, Inc. Continuous cell programming devices
US8561870B2 (en) 2008-02-13 2013-10-22 Ethicon Endo-Surgery, Inc. Surgical stapling instrument
US7819298B2 (en) 2008-02-14 2010-10-26 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with control features operable with one hand
JP5410110B2 (en) 2008-02-14 2014-02-05 エシコン・エンド−サージェリィ・インコーポレイテッド Surgical cutting / fixing instrument with RF electrode
US8636736B2 (en) 2008-02-14 2014-01-28 Ethicon Endo-Surgery, Inc. Motorized surgical cutting and fastening instrument
US9179912B2 (en) 2008-02-14 2015-11-10 Ethicon Endo-Surgery, Inc. Robotically-controlled motorized surgical cutting and fastening instrument
US8657174B2 (en) 2008-02-14 2014-02-25 Ethicon Endo-Surgery, Inc. Motorized surgical cutting and fastening instrument having handle based power source
US7866527B2 (en) 2008-02-14 2011-01-11 Ethicon Endo-Surgery, Inc. Surgical stapling apparatus with interlockable firing system
US8573465B2 (en) 2008-02-14 2013-11-05 Ethicon Endo-Surgery, Inc. Robotically-controlled surgical end effector system with rotary actuated closure systems
US8758391B2 (en) 2008-02-14 2014-06-24 Ethicon Endo-Surgery, Inc. Interchangeable tools for surgical instruments
US11272927B2 (en) 2008-02-15 2022-03-15 Cilag Gmbh International Layer arrangements for surgical staple cartridges
US20130153641A1 (en) 2008-02-15 2013-06-20 Ethicon Endo-Surgery, Inc. Releasable layer of material and surgical end effector having the same
WO2009104182A2 (en) 2008-02-18 2009-08-27 Polytouch Medical Ltd A device and method for deploying and attaching a patch to a biological tissue
US9398944B2 (en) 2008-02-18 2016-07-26 Covidien Lp Lock bar spring and clip for implant deployment device
US9833240B2 (en) 2008-02-18 2017-12-05 Covidien Lp Lock bar spring and clip for implant deployment device
US8317808B2 (en) 2008-02-18 2012-11-27 Covidien Lp Device and method for rolling and inserting a prosthetic patch into a body cavity
US9301826B2 (en) 2008-02-18 2016-04-05 Covidien Lp Lock bar spring and clip for implant deployment device
US9393002B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US8758373B2 (en) 2008-02-18 2014-06-24 Covidien Lp Means and method for reversibly connecting a patch to a patch deployment device
US9044235B2 (en) 2008-02-18 2015-06-02 Covidien Lp Magnetic clip for implant deployment device
US9034002B2 (en) 2008-02-18 2015-05-19 Covidien Lp Lock bar spring and clip for implant deployment device
US9393093B2 (en) 2008-02-18 2016-07-19 Covidien Lp Clip for implant deployment device
US8808314B2 (en) 2008-02-18 2014-08-19 Covidien Lp Device and method for deploying and attaching an implant to a biological tissue
ES2706295T3 (en) 2008-02-21 2019-03-28 Ethicon Llc Method and apparatus for raising retainers in self-retaining sutures
US8216273B1 (en) 2008-02-25 2012-07-10 Ethicon, Inc. Self-retainers with supporting structures on a suture
US8641732B1 (en) 2008-02-26 2014-02-04 Ethicon, Inc. Self-retaining suture with variable dimension filament and method
US20150135580A1 (en) * 2008-02-28 2015-05-21 College Of William And Mary Fishing gear with degradable component
WO2009111626A2 (en) 2008-03-05 2009-09-11 Conformis, Inc. Implants for altering wear patterns of articular surfaces
US20090228021A1 (en) * 2008-03-06 2009-09-10 Leung Jeffrey C Matrix material
US20130165967A1 (en) 2008-03-07 2013-06-27 W.L. Gore & Associates, Inc. Heart occlusion devices
WO2009129251A2 (en) 2008-04-15 2009-10-22 Angiotech Pharmaceuticals, Inc. Self-retaining sutures with bi-directional retainers or uni-directional retainers
JP5726068B2 (en) 2008-05-02 2015-05-27 プロビデンス ヘルス システム−オレゴン ディー／ビー／エー プロビデンス セント ビンセント メディカル センター Wound dressing device and method
US8470045B2 (en) * 2008-05-05 2013-06-25 K2M, Inc. Endplate for an intervertebral prosthesis and prosthesis incorporating the same
WO2009146456A1 (en) * 2008-05-30 2009-12-03 President And Fellows Of Harvard College Controlled release of growth factors and signaling molecules for promoting angiogenesis
US20090319031A1 (en) * 2008-06-19 2009-12-24 Yunbing Wang Bioabsorbable Polymeric Stent With Improved Structural And Molecular Weight Integrity
EP2303183A4 (en) * 2008-06-24 2015-11-04 Bioactive Surgical Inc Surgical sutures incorporated with stem cells or other bioactive materials
WO2009158724A2 (en) * 2008-06-27 2009-12-30 Tepha, Inc. Improved injectable delivery of microparticles and compositions therefore
WO2010017459A1 (en) 2008-08-07 2010-02-11 Bioactive Surgical, Inc> Stem cell capture and immobilization coatings for medical devices and implants
US20100040660A1 (en) * 2008-08-12 2010-02-18 Korea Research Institute Of Chemical Technology Development of a tissue - engineered scaffold for nerve regeneration using a biocompatible and injectable hydrogel
US9050184B2 (en) 2008-08-13 2015-06-09 Allergan, Inc. Dual plane breast implant
US20110208299A1 (en) * 2008-08-19 2011-08-25 Roelof Marissen Implantable valve prosthesis and method for manufacturing such a valve
US8642063B2 (en) * 2008-08-22 2014-02-04 Cook Medical Technologies Llc Implantable medical device coatings with biodegradable elastomer and releasable taxane agent
DE102008045237B4 (en) 2008-08-28 2010-07-29 Helmholtz-Zentrum Für Umweltforschung Gmbh - Ufz Method for the simultaneous production of PHA and compatible solutes in halophilic bacteria
PL3476312T3 (en) 2008-09-19 2024-03-11 Ethicon Llc Surgical stapler with apparatus for adjusting staple height
US9005230B2 (en) 2008-09-23 2015-04-14 Ethicon Endo-Surgery, Inc. Motorized surgical instrument
US11648005B2 (en) 2008-09-23 2023-05-16 Cilag Gmbh International Robotically-controlled motorized surgical instrument with an end effector
US9386983B2 (en) 2008-09-23 2016-07-12 Ethicon Endo-Surgery, Llc Robotically-controlled motorized surgical instrument
US8210411B2 (en) 2008-09-23 2012-07-03 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting instrument
WO2010040131A2 (en) * 2008-10-03 2010-04-08 Replication Medical, Inc. Vessel protection device
EP2340002B1 (en) 2008-10-06 2015-03-25 Providence Health System - Oregon Foam medical devices and methods
US8608045B2 (en) 2008-10-10 2013-12-17 Ethicon Endo-Sugery, Inc. Powered surgical cutting and stapling apparatus with manually retractable firing system
CA2730547C (en) 2008-10-20 2013-08-06 Polytouch Medical Ltd. A device for attaching a patch to a biological tissue
FR2937857B1 (en) * 2008-10-30 2015-04-03 Brothier Lab SURGICAL MEMBRANE ANTIADHERENCE
EP2352440B1 (en) 2008-11-03 2019-02-20 Ethicon LLC Length of self-retaining suture and device for using the same
US7886951B2 (en) 2008-11-24 2011-02-15 Tyco Healthcare Group Lp Pouch used to deliver medication when ruptured
CN105056308A (en) 2009-01-08 2015-11-18 Biodg股份有限公司 Implantable medical devices comprising bio-degradable alloys
US8517239B2 (en) 2009-02-05 2013-08-27 Ethicon Endo-Surgery, Inc. Surgical stapling instrument comprising a magnetic element driver
US8444036B2 (en) 2009-02-06 2013-05-21 Ethicon Endo-Surgery, Inc. Motor driven surgical fastener device with mechanisms for adjusting a tissue gap within the end effector
EP2393430A1 (en) 2009-02-06 2011-12-14 Ethicon Endo-Surgery, Inc. Driven surgical stapler improvements
US9017334B2 (en) 2009-02-24 2015-04-28 Microport Orthopedics Holdings Inc. Patient specific surgical guide locator and mount
WO2010099231A2 (en) 2009-02-24 2010-09-02 Conformis, Inc. Automated systems for manufacturing patient-specific orthopedic implants and instrumentation
US8808297B2 (en) 2009-02-24 2014-08-19 Microport Orthopedics Holdings Inc. Orthopedic surgical guide
US8808303B2 (en) 2009-02-24 2014-08-19 Microport Orthopedics Holdings Inc. Orthopedic surgical guide
WO2010120749A2 (en) 2009-04-13 2010-10-21 President And Fellow Of Harvard College Harnessing cell dynamics to engineer materials
SG175229A1 (en) 2009-04-16 2011-11-28 Conformis Inc Patient-specific joint arthroplasty devices for ligament repair
DE102009020894A1 (en) * 2009-05-08 2010-11-11 Aesculap Ag Elastomeric thread with anchoring structures for anchoring in biological tissues
GB2470378A (en) * 2009-05-20 2010-11-24 Univ Westminster A controlled release composition for intraocular delivery of a therapeutic agent
US8956389B2 (en) 2009-06-22 2015-02-17 W. L. Gore & Associates, Inc. Sealing device and delivery system
US20120029556A1 (en) 2009-06-22 2012-02-02 Masters Steven J Sealing device and delivery system
EP2451496B1 (en) 2009-07-10 2015-07-22 Boston Scientific Scimed, Inc. Use of nanocrystals for a drug delivery balloon
US8888828B2 (en) 2009-07-16 2014-11-18 Covidien Lp Composite fixation device
EP2962707B1 (en) * 2009-07-17 2019-07-24 Boston Scientific Scimed, Inc. Drug delivery balloons with improved crystal size and density
US20110015672A1 (en) * 2009-07-17 2011-01-20 Tyco Healthcare Group Lp Method for Coating a Medical Device
US20110021869A1 (en) * 2009-07-24 2011-01-27 Hilary John Cholhan Single-incision minimally-invasive surgical repair of pelvic organ/vaginal prolapse conditions
EP2461828B1 (en) 2009-07-31 2017-06-21 President and Fellows of Harvard College Programming of cells for tolerogenic therapies
US9999424B2 (en) 2009-08-17 2018-06-19 Covidien Lp Means and method for reversibly connecting an implant to a deployment device
WO2011021083A1 (en) 2009-08-17 2011-02-24 PolyTouch Medical, Inc. Articulating patch deployment device and method of use
EP3607888A1 (en) 2009-09-07 2020-02-12 Aeeg Ab Device and kit for closure of a body lumen puncture
WO2011032139A2 (en) * 2009-09-14 2011-03-17 Virginia Commonwealth University Electrospun nerve guides for nerve regeneration designed to modulate nerve architecture
US20110166598A1 (en) * 2009-12-02 2011-07-07 Entrigue Surgical, Inc. Devices and methods for tongue stabilization
EP2509539B1 (en) 2009-12-11 2020-07-01 ConforMIS, Inc. Patient-specific and patient-engineered orthopedic implants
US8220688B2 (en) 2009-12-24 2012-07-17 Ethicon Endo-Surgery, Inc. Motor-driven surgical cutting instrument with electric actuator directional control assembly
US8851354B2 (en) 2009-12-24 2014-10-07 Ethicon Endo-Surgery, Inc. Surgical cutting instrument that analyzes tissue thickness
WO2011090628A2 (en) 2009-12-29 2011-07-28 Angiotech Pharmaceuticals, Inc. Bidirectional self-retaining sutures with laser-marked and/or non-laser marked indicia and methods
US20110160645A1 (en) * 2009-12-31 2011-06-30 Boston Scientific Scimed, Inc. Cryo Activated Drug Delivery and Cutting Balloons
CN102791776B (en) 2010-01-12 2015-11-25 绿岩有限责任公司 Imitative paper film and its preparation method
US8877822B2 (en) 2010-09-28 2014-11-04 Allergan, Inc. Porogen compositions, methods of making and uses
US9205577B2 (en) 2010-02-05 2015-12-08 Allergan, Inc. Porogen compositions, methods of making and uses
US9138309B2 (en) 2010-02-05 2015-09-22 Allergan, Inc. Porous materials, methods of making and uses
WO2011103141A1 (en) 2010-02-16 2011-08-25 Ams Research Corporation Bioabsorbable mesh for surgical implants
WO2011103158A1 (en) * 2010-02-16 2011-08-25 Michael Darryl Black Systems and methods that kill infectious agents (bacteria) without the use of a systemic anti-biotic
EP2558133B1 (en) 2010-03-26 2020-01-22 Tepha, Inc. Coatings for the manufacture and application of polyhydroxyalkanoate medical devices
NZ702869A (en) 2010-05-04 2016-05-27 Ethicon Llc Self-retaining systems having laser-cut retainers
AU2011252023B2 (en) * 2010-05-11 2015-05-21 Allergan, Inc. Porous materials, methods of making and uses
US11202853B2 (en) 2010-05-11 2021-12-21 Allergan, Inc. Porogen compositions, methods of making and uses
CA2801271C (en) 2010-06-11 2018-10-30 Ethicon, Llc Suture delivery tools for endoscopic and robot-assisted surgery and methods
EP2582866B1 (en) 2010-06-15 2014-09-17 Tepha, Inc. Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers
US9511169B2 (en) * 2010-06-15 2016-12-06 Tepha, Inc. Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers with anisotropic properties
US9693954B2 (en) 2010-06-25 2017-07-04 President And Fellows Of Harvard College Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones
US8783543B2 (en) 2010-07-30 2014-07-22 Ethicon Endo-Surgery, Inc. Tissue acquisition arrangements and methods for surgical stapling devices
DE102010034471A1 (en) * 2010-08-06 2012-02-09 Aesculap Ag Thread, in particular surgical thread, an implant comprising the thread and a method for producing the thread and the implant
EP2425865A1 (en) * 2010-08-06 2012-03-07 Aesculap AG Medicinal thread having a polyhydroxyalkanoate coating
AU2011293344B2 (en) 2010-08-25 2015-07-30 Medtronic, Inc. Novel medical device coatings
EP2611476B1 (en) 2010-09-02 2016-08-10 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
US8758374B2 (en) 2010-09-15 2014-06-24 University Of Utah Research Foundation Method for connecting nerves via a side-to-side epineurial window using artificial conduits
US9364233B2 (en) 2010-09-30 2016-06-14 Ethicon Endo-Surgery, Llc Tissue thickness compensators for circular surgical staplers
US9414838B2 (en) 2012-03-28 2016-08-16 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprised of a plurality of materials
US9566061B2 (en) 2010-09-30 2017-02-14 Ethicon Endo-Surgery, Llc Fastener cartridge comprising a releasably attached tissue thickness compensator
US9220501B2 (en) 2010-09-30 2015-12-29 Ethicon Endo-Surgery, Inc. Tissue thickness compensators
US9277919B2 (en) 2010-09-30 2016-03-08 Ethicon Endo-Surgery, Llc Tissue thickness compensator comprising fibers to produce a resilient load
US11812965B2 (en) 2010-09-30 2023-11-14 Cilag Gmbh International Layer of material for a surgical end effector
US9307989B2 (en) 2012-03-28 2016-04-12 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorportating a hydrophobic agent
US9839420B2 (en) 2010-09-30 2017-12-12 Ethicon Llc Tissue thickness compensator comprising at least one medicament
US9629814B2 (en) 2010-09-30 2017-04-25 Ethicon Endo-Surgery, Llc Tissue thickness compensator configured to redistribute compressive forces
US11849952B2 (en) 2010-09-30 2023-12-26 Cilag Gmbh International Staple cartridge comprising staples positioned within a compressible portion thereof
US9301753B2 (en) 2010-09-30 2016-04-05 Ethicon Endo-Surgery, Llc Expandable tissue thickness compensator
US9517063B2 (en) 2012-03-28 2016-12-13 Ethicon Endo-Surgery, Llc Movable member for use with a tissue thickness compensator
US9314246B2 (en) 2010-09-30 2016-04-19 Ethicon Endo-Surgery, Llc Tissue stapler having a thickness compensator incorporating an anti-inflammatory agent
US9386988B2 (en) 2010-09-30 2016-07-12 Ethicon End-Surgery, LLC Retainer assembly including a tissue thickness compensator
US9332974B2 (en) 2010-09-30 2016-05-10 Ethicon Endo-Surgery, Llc Layered tissue thickness compensator
EP2621356B1 (en) 2010-09-30 2018-03-07 Ethicon LLC Fastener system comprising a retention matrix and an alignment matrix
US8746535B2 (en) 2010-09-30 2014-06-10 Ethicon Endo-Surgery, Inc. Tissue thickness compensator comprising detachable portions
US10945731B2 (en) 2010-09-30 2021-03-16 Ethicon Llc Tissue thickness compensator comprising controlled release and expansion
US11298125B2 (en) 2010-09-30 2022-04-12 Cilag Gmbh International Tissue stapler having a thickness compensator
US9216019B2 (en) 2011-09-23 2015-12-22 Ethicon Endo-Surgery, Inc. Surgical stapler with stationary staple drivers
US8695866B2 (en) 2010-10-01 2014-04-15 Ethicon Endo-Surgery, Inc. Surgical instrument having a power control circuit
WO2012048105A1 (en) 2010-10-06 2012-04-12 Ams Research Corporation Implants with absorbable and non-absorbable features for the treatment of female pelvic conditions
PT2624873T (en) 2010-10-06 2020-03-04 Harvard College Injectable, pore-forming hydrogels for materials-based cell therapies
US9861590B2 (en) * 2010-10-19 2018-01-09 Covidien Lp Self-supporting films for delivery of therapeutic agents
CA2816326C (en) 2010-11-03 2020-12-15 Ethicon, Llc Drug-eluting self-retaining sutures and methods relating thereto
WO2012064697A2 (en) 2010-11-08 2012-05-18 President And Fellows Of Harvard College Materials presenting notch signaling molecules to control cell behavior
MX342984B (en) 2010-11-09 2016-10-19 Ethicon Llc Emergency self-retaining sutures and packaging.
US9162010B2 (en) 2010-11-09 2015-10-20 Tepha, Inc. Drug eluting cochlear implants
JP6397190B2 (en) 2010-11-12 2018-09-26 タイレックス・インコーポレイテッドＴｙｒｘ Ｉｎｃ． Fixing device containing active pharmaceutical ingredients
US8679279B2 (en) 2010-11-16 2014-03-25 Allergan, Inc. Methods for creating foam-like texture
KR101250700B1 (en) 2010-12-06 2013-04-03 성균관대학교산학협력단 Degradability velocity control method of biodegradable magnesium and biodegradable magnesium using thereof
CA2825624C (en) 2011-01-27 2020-01-14 Osa Holdings, Inc. Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
US9421132B2 (en) 2011-02-04 2016-08-23 University Of Massachusetts Negative pressure wound closure device
WO2012106590A2 (en) 2011-02-04 2012-08-09 University Of Massachusetts Negative pressure wound closure device
SG193484A1 (en) 2011-02-15 2013-10-30 Conformis Inc Patent-adapted and improved articular implants, designs, surgical procedures and related guide tools
CA2829201C (en) * 2011-03-09 2019-03-12 Tepha, Inc. Systems and methods for mastopexy
EP2497426B1 (en) 2011-03-09 2016-12-14 Aeeg Ab Device and kit for closure of a body lumen puncture
AU2012230716B2 (en) 2011-03-23 2016-05-19 Ethicon Llc Self-retaining variable loop sutures
EP2701753B1 (en) 2011-04-27 2018-12-26 President and Fellows of Harvard College Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
EP3417876B1 (en) 2011-04-28 2021-03-31 President and Fellows of Harvard College Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration
US9017711B2 (en) 2011-04-28 2015-04-28 Warsaw Orthopedic, Inc. Soft tissue wrap
AU2012250197B2 (en) 2011-04-29 2017-08-10 Ethicon Endo-Surgery, Inc. Staple cartridge comprising staples positioned within a compressible portion thereof
US9072535B2 (en) 2011-05-27 2015-07-07 Ethicon Endo-Surgery, Inc. Surgical stapling instruments with rotatable staple deployment arrangements
US11207064B2 (en) 2011-05-27 2021-12-28 Cilag Gmbh International Automated end effector component reloading system for use with a robotic system
JP6062426B2 (en) 2011-06-03 2017-01-18 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ In situ antigen-producing cancer vaccine
US20130172931A1 (en) 2011-06-06 2013-07-04 Jeffrey M. Gross Methods and devices for soft palate tissue elevation procedures
DK2537540T3 (en) 2011-06-20 2014-06-02 Tech Universität Graz Hybrid polymeric materials for medical applications as well as their manufacture
EP2543339A1 (en) 2011-07-05 2013-01-09 Aesculap AG Surgical implant, in particular for use as a hernia repair implant
US8998059B2 (en) 2011-08-01 2015-04-07 Ethicon Endo-Surgery, Inc. Adjunct therapy device having driver with cavity for hemostatic agent
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
US9492170B2 (en) 2011-08-10 2016-11-15 Ethicon Endo-Surgery, Inc. Device for applying adjunct in endoscopic procedure
US9770232B2 (en) 2011-08-12 2017-09-26 W. L. Gore & Associates, Inc. Heart occlusion devices
US9056152B2 (en) 2011-08-25 2015-06-16 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
US9370482B1 (en) 2011-09-09 2016-06-21 Harrison Yu Method of incorporating additives to shaped porous monocomponent biopolymer fibers during fiber orienting step
US8998060B2 (en) 2011-09-13 2015-04-07 Ethicon Endo-Surgery, Inc. Resistive heated surgical staple cartridge with phase change sealant
US9101359B2 (en) 2011-09-13 2015-08-11 Ethicon Endo-Surgery, Inc. Surgical staple cartridge with self-dispensing staple buttress
US9999408B2 (en) 2011-09-14 2018-06-19 Ethicon Endo-Surgery, Inc. Surgical instrument with fluid fillable buttress
US9125649B2 (en) 2011-09-15 2015-09-08 Ethicon Endo-Surgery, Inc. Surgical instrument with filled staple
US8814025B2 (en) 2011-09-15 2014-08-26 Ethicon Endo-Surgery, Inc. Fibrin pad matrix with suspended heat activated beads of adhesive
US9254180B2 (en) 2011-09-15 2016-02-09 Ethicon Endo-Surgery, Inc. Surgical instrument with staple reinforcement clip
US9198644B2 (en) 2011-09-22 2015-12-01 Ethicon Endo-Surgery, Inc. Anvil cartridge for surgical fastening device
US9393018B2 (en) 2011-09-22 2016-07-19 Ethicon Endo-Surgery, Inc. Surgical staple assembly with hemostatic feature
US8985429B2 (en) 2011-09-23 2015-03-24 Ethicon Endo-Surgery, Inc. Surgical stapling device with adjunct material application feature
US9050084B2 (en) 2011-09-23 2015-06-09 Ethicon Endo-Surgery, Inc. Staple cartridge including collapsible deck arrangement
ES2659525T3 (en) 2011-09-27 2018-03-16 Tepha, Inc. Controlled hydrolysis of poly-4-hydroxybutyrate and copolymers
US8899464B2 (en) 2011-10-03 2014-12-02 Ethicon Endo-Surgery, Inc. Attachment of surgical staple buttress to cartridge
US9089326B2 (en) 2011-10-07 2015-07-28 Ethicon Endo-Surgery, Inc. Dual staple cartridge for surgical stapler
WO2013066619A1 (en) 2011-10-17 2013-05-10 University Of Utah Research Foundation Methods and devices for connecting nerves
US10842494B2 (en) 2011-10-17 2020-11-24 University Of Utah Research Foundation Methods and devices for connecting nerves
US9561059B1 (en) 2011-11-23 2017-02-07 Nuvasive, Inc. Minimally invasive facet release
US9113866B2 (en) 2011-12-15 2015-08-25 Ethicon Endo-Surgery, Inc. Devices and methods for endoluminal plication
US9173657B2 (en) 2011-12-15 2015-11-03 Ethicon Endo-Surgery, Inc. Devices and methods for endoluminal plication
US9044230B2 (en) 2012-02-13 2015-06-02 Ethicon Endo-Surgery, Inc. Surgical cutting and fastening instrument with apparatus for determining cartridge and firing motion status
US8992547B2 (en) 2012-03-21 2015-03-31 Ethicon Endo-Surgery, Inc. Methods and devices for creating tissue plications
JP5900909B2 (en) * 2012-03-27 2016-04-06 国立大学法人名古屋大学 Three-dimensional structure made from material containing polyhydroxyalkanoate and kit for preparing bone filler
RU2639857C2 (en) 2012-03-28 2017-12-22 Этикон Эндо-Серджери, Инк. Tissue thickness compensator containing capsule for medium with low pressure
RU2644272C2 (en) 2012-03-28 2018-02-08 Этикон Эндо-Серджери, Инк. Limitation node with tissue thickness compensator
US9198662B2 (en) 2012-03-28 2015-12-01 Ethicon Endo-Surgery, Inc. Tissue thickness compensator having improved visibility
MX358135B (en) 2012-03-28 2018-08-06 Ethicon Endo Surgery Inc Tissue thickness compensator comprising a plurality of layers.
WO2013158673A1 (en) 2012-04-16 2013-10-24 President And Fellows Of Harvard College Mesoporous silica compositions for modulating immune responses
US9486226B2 (en) 2012-04-18 2016-11-08 Conformis, Inc. Tibial guides, tools, and techniques for resecting the tibial plateau
ES2822000T3 (en) 2012-05-21 2021-04-28 Tepha Inc Resorbable bioceramics compositions of poly-4-hydroxybutyrate and copolymers
MX2014014266A (en) 2012-05-22 2015-06-23 Smith & Nephew Apparatuses and methods for wound therapy.
CA2874396A1 (en) 2012-05-22 2014-01-23 Smith & Nephew Plc Wound closure device
EP3470029A1 (en) 2012-05-24 2019-04-17 Smith & Nephew, Inc. Devices for treating and closing wounds with negative pressure
US9675471B2 (en) 2012-06-11 2017-06-13 Conformis, Inc. Devices, techniques and methods for assessing joint spacing, balancing soft tissues and obtaining desired kinematics for joint implant components
US9101358B2 (en) 2012-06-15 2015-08-11 Ethicon Endo-Surgery, Inc. Articulatable surgical instrument comprising a firing drive
US9649111B2 (en) 2012-06-28 2017-05-16 Ethicon Endo-Surgery, Llc Replaceable clip cartridge for a clip applier
US20140001231A1 (en) 2012-06-28 2014-01-02 Ethicon Endo-Surgery, Inc. Firing system lockout arrangements for surgical instruments
US9101385B2 (en) 2012-06-28 2015-08-11 Ethicon Endo-Surgery, Inc. Electrode connections for rotary driven surgical tools
BR112014032776B1 (en) 2012-06-28 2021-09-08 Ethicon Endo-Surgery, Inc SURGICAL INSTRUMENT SYSTEM AND SURGICAL KIT FOR USE WITH A SURGICAL INSTRUMENT SYSTEM
US11202631B2 (en) 2012-06-28 2021-12-21 Cilag Gmbh International Stapling assembly comprising a firing lockout
US20140005718A1 (en) 2012-06-28 2014-01-02 Ethicon Endo-Surgery, Inc. Multi-functional powered surgical device with external dissection features
US9226751B2 (en) 2012-06-28 2016-01-05 Ethicon Endo-Surgery, Inc. Surgical instrument system including replaceable end effectors
US9289256B2 (en) 2012-06-28 2016-03-22 Ethicon Endo-Surgery, Llc Surgical end effectors having angled tissue-contacting surfaces
EP2866686A1 (en) 2012-06-28 2015-05-06 Ethicon Endo-Surgery, Inc. Empty clip cartridge lockout
CN110448407B (en) 2012-07-16 2022-08-09 史密夫和内修有限公司 Negative pressure wound closure device
US10016527B2 (en) 2012-10-23 2018-07-10 Orthovita, Inc. Materials and methods for repair of cartilage defects
CA2891118C (en) 2012-11-12 2017-07-04 Hollister Incorporated Intermittent catheter assembly and kit
HUE041859T2 (en) 2012-11-14 2019-06-28 Hollister Inc Disposable catheter with selectively degradable inner core
ES2774932T3 (en) 2012-11-14 2020-07-23 Cj Cheiljedang Corp Production of 4-hydroxybutyrate salts using bio-based raw materials
WO2014093669A1 (en) 2012-12-13 2014-06-19 Allergan, Inc. Device and method for making a variable surface breast implant
US9522002B2 (en) 2012-12-13 2016-12-20 Covidien Lp Surgical instrument with pressure distribution device
US9949692B2 (en) 2012-12-21 2018-04-24 Canary Medical Inc. Stent graft monitoring assembly and method of use thereof
US20140186441A1 (en) * 2012-12-28 2014-07-03 DePuy Synthes Products, LLC Composites for Osteosynthesis
ES2751398T3 (en) 2013-01-15 2020-03-31 Tepha Inc Implants for regeneration of soft tissue and hard tissue
US10828019B2 (en) 2013-01-18 2020-11-10 W.L. Gore & Associates, Inc. Sealing device and delivery system
US9386984B2 (en) 2013-02-08 2016-07-12 Ethicon Endo-Surgery, Llc Staple cartridge comprising a releasable cover
RU2669463C2 (en) 2013-03-01 2018-10-11 Этикон Эндо-Серджери, Инк. Surgical instrument with soft stop
US9358003B2 (en) 2013-03-01 2016-06-07 Ethicon Endo-Surgery, Llc Electromechanical surgical device with signal relay arrangement
RU2672520C2 (en) 2013-03-01 2018-11-15 Этикон Эндо-Серджери, Инк. Hingedly turnable surgical instruments with conducting ways for signal transfer
US9345481B2 (en) 2013-03-13 2016-05-24 Ethicon Endo-Surgery, Llc Staple cartridge tissue thickness sensor system
BR112015021854A2 (en) 2013-03-13 2017-07-18 Smith & Nephew Inc negative pressure wound closure device and systems and methods of use in treating negative pressure wound
US9290612B2 (en) 2013-03-13 2016-03-22 Tepha, Inc. Compositions and devices of poly-4-hydroxybutyrate
US10201640B2 (en) 2013-03-13 2019-02-12 Tepha, Inc. Ultrafine electrospun fibers of poly-4-hydroxybutyrate and copolymers thereof
CA2906162C (en) 2013-03-14 2022-08-23 Paul Jablonski Implantable medical devices comprising bio-degradable alloys with enhanced degradation rates
RU2015142877A (en) 2013-03-14 2017-04-18 СМИТ ЭНД НЕФЬЮ ПиЭлСи COMPRESSIBLE WOUND FILLERS AND SYSTEMS AND WAYS OF THEIR APPLICATION IN THE TREATMENT OF THE RAS WITH APPLICATION OF NEGATIVE PRESSURE
US9332987B2 (en) 2013-03-14 2016-05-10 Ethicon Endo-Surgery, Llc Control arrangements for a drive member of a surgical instrument
US9629629B2 (en) 2013-03-14 2017-04-25 Ethicon Endo-Surgey, LLC Control systems for surgical instruments
WO2014144070A1 (en) 2013-03-15 2014-09-18 Hunter William L Stent monitoring assembly and method of use thereof
US9572577B2 (en) 2013-03-27 2017-02-21 Ethicon Endo-Surgery, Llc Fastener cartridge comprising a tissue thickness compensator including openings therein
US9332984B2 (en) 2013-03-27 2016-05-10 Ethicon Endo-Surgery, Llc Fastener cartridge assemblies
US9795384B2 (en) 2013-03-27 2017-10-24 Ethicon Llc Fastener cartridge comprising a tissue thickness compensator and a gap setting element
BR112015026109B1 (en) 2013-04-16 2022-02-22 Ethicon Endo-Surgery, Inc surgical instrument
US9867612B2 (en) 2013-04-16 2018-01-16 Ethicon Llc Powered surgical stapler
WO2014186435A2 (en) 2013-05-14 2014-11-20 University Of Georgia Research Foundation, Inc. Compositions and methods for reducing neointima formation
US9574644B2 (en) 2013-05-30 2017-02-21 Ethicon Endo-Surgery, Llc Power module for use with a surgical instrument
CA2917427C (en) 2013-07-10 2019-06-18 Tepha, Inc. Soft suture anchors
AU2014286999B2 (en) 2013-07-11 2017-04-13 Tepha, Inc. Absorbable implants for plastic surgery
US9655715B2 (en) 2013-07-11 2017-05-23 Tepha, Inc. Absorbable implants for plastic surgery
US10689498B2 (en) 2013-08-20 2020-06-23 Tepha, Inc. Closed cell foams including poly-4-hydroxybutyrate and copolymers thereof
US9687585B2 (en) 2013-08-20 2017-06-27 Tepha, Inc. Thermoformed poly-4-hydroxybutyrate medical implants
MX369362B (en) 2013-08-23 2019-11-06 Ethicon Endo Surgery Llc Firing member retraction devices for powered surgical instruments.
US9775609B2 (en) 2013-08-23 2017-10-03 Ethicon Llc Tamper proof circuit for surgical instrument battery pack
US9964510B2 (en) 2013-09-16 2018-05-08 Dionex Corporation Electrolytic four-channel device and method
JP6723917B2 (en) 2013-10-21 2020-07-15 スミス アンド ネフュー インコーポレイテッド Negative pressure wound closure device
US9302029B2 (en) 2013-10-31 2016-04-05 Tepha, Inc. Pultrusion of poly-4-hydroxybutyrate and copolymers thereof
US20160250385A1 (en) * 2013-11-04 2016-09-01 The Trustees Of The University Of Pennsylvania Neuronal replacement and reestablishment of axonal connections
CA2928731A1 (en) 2013-11-05 2015-05-14 Tepha, Inc. Compositions and devices of poly-4-hydroxybutyrate
LT3862031T (en) 2013-11-08 2023-09-25 Hollister Incorporated Oleophilic lubricated catheters
US9763911B2 (en) * 2013-12-12 2017-09-19 Mayo Foundation For Medical Education And Research Prostacyclin compositions for regulation of fracture repair and bone formation
ES2762743T3 (en) 2013-12-12 2020-05-25 Hollister Inc Downloadable catheters
AU2014362360B2 (en) 2013-12-12 2020-01-02 Hollister Incorporated Flushable catheters
ES2802948T3 (en) 2013-12-12 2021-01-22 Hollister Inc Disintegrable catheter disposable for a toilet
CA2933525C (en) 2013-12-12 2020-11-17 Hollister Incorporated Flushable catheters
WO2015094619A1 (en) 2013-12-19 2015-06-25 Tornier, Inc. High-strength bioabsorbable suture
US9763662B2 (en) 2013-12-23 2017-09-19 Ethicon Llc Fastener cartridge comprising a firing member configured to directly engage and eject fasteners from the fastener cartridge
US20150173756A1 (en) 2013-12-23 2015-06-25 Ethicon Endo-Surgery, Inc. Surgical cutting and stapling methods
US9724092B2 (en) 2013-12-23 2017-08-08 Ethicon Llc Modular surgical instruments
US9839428B2 (en) 2013-12-23 2017-12-12 Ethicon Llc Surgical cutting and stapling instruments with independent jaw control features
ES2834498T3 (en) 2013-12-26 2021-06-17 Tepha Inc Medical implants including poly-4-hydroxybutyrate laminates and copolymers thereof
JP6742908B2 (en) 2014-01-21 2020-08-19 スミス アンド ネフュー ピーエルシーＳｍｉｔｈ ＆ Ｎｅｐｈｅｗ Ｐｕｂｌｉｃ Ｌｉｍｉｔｅｄ Ｃｏｍｐａｎｙ Crushable negative pressure wound dressing
US9962161B2 (en) 2014-02-12 2018-05-08 Ethicon Llc Deliverable surgical instrument
US20140166725A1 (en) 2014-02-24 2014-06-19 Ethicon Endo-Surgery, Inc. Staple cartridge including a barbed staple.
JP6462004B2 (en) 2014-02-24 2019-01-30 エシコン エルエルシー Fastening system with launcher lockout
ES2685963T3 (en) 2014-03-18 2018-10-15 Tepha, Inc. Microfiber bands of poly-4-hydroxybutyrate and their copolymers produced by centrifugal spinning
BR112016021943B1 (en) 2014-03-26 2022-06-14 Ethicon Endo-Surgery, Llc SURGICAL INSTRUMENT FOR USE BY AN OPERATOR IN A SURGICAL PROCEDURE
US10028761B2 (en) 2014-03-26 2018-07-24 Ethicon Llc Feedback algorithms for manual bailout systems for surgical instruments
US20150272557A1 (en) 2014-03-26 2015-10-01 Ethicon Endo-Surgery, Inc. Modular surgical instrument system
US9826977B2 (en) 2014-03-26 2017-11-28 Ethicon Llc Sterilization verification circuit
US9913642B2 (en) 2014-03-26 2018-03-13 Ethicon Llc Surgical instrument comprising a sensor system
JP6532889B2 (en) 2014-04-16 2019-06-19 エシコン エルエルシーＥｔｈｉｃｏｎ ＬＬＣ Fastener cartridge assembly and staple holder cover arrangement
JP6612256B2 (en) 2014-04-16 2019-11-27 エシコン エルエルシー Fastener cartridge with non-uniform fastener
US10206677B2 (en) 2014-09-26 2019-02-19 Ethicon Llc Surgical staple and driver arrangements for staple cartridges
US20150297223A1 (en) 2014-04-16 2015-10-22 Ethicon Endo-Surgery, Inc. Fastener cartridges including extensions having different configurations
US9844369B2 (en) 2014-04-16 2017-12-19 Ethicon Llc Surgical end effectors with firing element monitoring arrangements
CN106456176B (en) 2014-04-16 2019-06-28 伊西康内外科有限责任公司 Fastener cartridge including the extension with various configuration
WO2015167807A1 (en) 2014-04-30 2015-11-05 Tepha, Inc. Three-dimensional resorbable implants for tissue reinforcement and hernia repair
EP3137105A4 (en) 2014-04-30 2017-12-27 President and Fellows of Harvard College Combination vaccine devices and methods of killing cancer cells
US10092392B2 (en) 2014-05-16 2018-10-09 Allergan, Inc. Textured breast implant and methods of making same
ES2674807T3 (en) 2014-05-16 2018-07-04 Tepha, Inc. Medical devices containing dry-spun non-woven poly-4-hydroxybutyrate materials and copolymers with anisotropic properties
US9808230B2 (en) 2014-06-06 2017-11-07 W. L. Gore & Associates, Inc. Sealing device and delivery system
US11638640B2 (en) 2014-06-11 2023-05-02 Bard Shannon Limited In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material
US10595986B2 (en) 2014-06-11 2020-03-24 Robert D. Rehnke Internal long term absorbable matrix brassiere and tissue engineering scaffold
US11883275B2 (en) 2014-06-11 2024-01-30 Bard Shannon Limited In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material
US10045781B2 (en) 2014-06-13 2018-08-14 Ethicon Llc Closure lockout systems for surgical instruments
WO2015200718A1 (en) 2014-06-25 2015-12-30 Hunter William L Devices, systems and methods for using and monitoring tubes in body passageways
CA2990814A1 (en) 2014-06-25 2015-12-30 William L. Hunter Devices, systems and methods for using and monitoring implants
US10500303B2 (en) 2014-08-15 2019-12-10 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
CA2958544C (en) 2014-08-20 2019-05-21 Tepha, Inc. Thermoformed poly-4-hydroxybutyrate medical implants
US11311294B2 (en) 2014-09-05 2022-04-26 Cilag Gmbh International Powered medical device including measurement of closure state of jaws
BR112017004361B1 (en) 2014-09-05 2023-04-11 Ethicon Llc ELECTRONIC SYSTEM FOR A SURGICAL INSTRUMENT
US20160066913A1 (en) 2014-09-05 2016-03-10 Ethicon Endo-Surgery, Inc. Local display of tissue parameter stabilization
CA2998709A1 (en) 2014-09-17 2016-03-24 Canary Medical Inc. Devices, systems and methods for using and monitoring medical devices
US10105142B2 (en) 2014-09-18 2018-10-23 Ethicon Llc Surgical stapler with plurality of cutting elements
WO2016048950A1 (en) * 2014-09-22 2016-03-31 Tepha, Inc. Oriented p4hb implants containing antimicrobial agents
JP6648119B2 (en) 2014-09-26 2020-02-14 エシコン エルエルシーＥｔｈｉｃｏｎ ＬＬＣ Surgical stapling buttress and accessory materials
US11523821B2 (en) 2014-09-26 2022-12-13 Cilag Gmbh International Method for creating a flexible staple line
EP3200736B8 (en) 2014-10-01 2020-06-17 CryOSA, Inc. Apparatus for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
US10076325B2 (en) 2014-10-13 2018-09-18 Ethicon Llc Surgical stapling apparatus comprising a tissue stop
US9924944B2 (en) 2014-10-16 2018-03-27 Ethicon Llc Staple cartridge comprising an adjunct material
US10517594B2 (en) 2014-10-29 2019-12-31 Ethicon Llc Cartridge assemblies for surgical staplers
US11141153B2 (en) 2014-10-29 2021-10-12 Cilag Gmbh International Staple cartridges comprising driver arrangements
US9844376B2 (en) 2014-11-06 2017-12-19 Ethicon Llc Staple cartridge comprising a releasable adjunct material
US10736636B2 (en) 2014-12-10 2020-08-11 Ethicon Llc Articulatable surgical instrument system
US9555155B2 (en) 2014-12-11 2017-01-31 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
US10004501B2 (en) 2014-12-18 2018-06-26 Ethicon Llc Surgical instruments with improved closure arrangements
US9987000B2 (en) 2014-12-18 2018-06-05 Ethicon Llc Surgical instrument assembly comprising a flexible articulation system
US10117649B2 (en) 2014-12-18 2018-11-06 Ethicon Llc Surgical instrument assembly comprising a lockable articulation system
US9844375B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Drive arrangements for articulatable surgical instruments
US10085748B2 (en) 2014-12-18 2018-10-02 Ethicon Llc Locking arrangements for detachable shaft assemblies with articulatable surgical end effectors
RU2703684C2 (en) 2014-12-18 2019-10-21 ЭТИКОН ЭНДО-СЕРДЖЕРИ, ЭлЭлСи Surgical instrument with anvil which is selectively movable relative to staple cartridge around discrete fixed axis
US9844374B2 (en) 2014-12-18 2017-12-19 Ethicon Llc Surgical instrument systems comprising an articulatable end effector and means for adjusting the firing stroke of a firing member
US10188385B2 (en) 2014-12-18 2019-01-29 Ethicon Llc Surgical instrument system comprising lockable systems
WO2016123573A1 (en) 2015-01-30 2016-08-04 President And Fellows Of Harvard College Peritumoral and intratumoral materials for cancer therapy
US20160249910A1 (en) 2015-02-27 2016-09-01 Ethicon Endo-Surgery, Llc Surgical charging system that charges and/or conditions one or more batteries
US10226250B2 (en) 2015-02-27 2019-03-12 Ethicon Llc Modular stapling assembly
US11154301B2 (en) 2015-02-27 2021-10-26 Cilag Gmbh International Modular stapling assembly
US10180463B2 (en) 2015-02-27 2019-01-15 Ethicon Llc Surgical apparatus configured to assess whether a performance parameter of the surgical apparatus is within an acceptable performance band
US10617412B2 (en) 2015-03-06 2020-04-14 Ethicon Llc System for detecting the mis-insertion of a staple cartridge into a surgical stapler
US9993248B2 (en) 2015-03-06 2018-06-12 Ethicon Endo-Surgery, Llc Smart sensors with local signal processing
US10441279B2 (en) 2015-03-06 2019-10-15 Ethicon Llc Multiple level thresholds to modify operation of powered surgical instruments
US9924961B2 (en) 2015-03-06 2018-03-27 Ethicon Endo-Surgery, Llc Interactive feedback system for powered surgical instruments
US10045776B2 (en) 2015-03-06 2018-08-14 Ethicon Llc Control techniques and sub-processor contained within modular shaft with select control processing from handle
US10687806B2 (en) 2015-03-06 2020-06-23 Ethicon Llc Adaptive tissue compression techniques to adjust closure rates for multiple tissue types
US9808246B2 (en) 2015-03-06 2017-11-07 Ethicon Endo-Surgery, Llc Method of operating a powered surgical instrument
US9901342B2 (en) 2015-03-06 2018-02-27 Ethicon Endo-Surgery, Llc Signal and power communication system positioned on a rotatable shaft
JP2020121162A (en) 2015-03-06 2020-08-13 エシコン エルエルシーＥｔｈｉｃｏｎ ＬＬＣ Time dependent evaluation of sensor data to determine stability element, creep element and viscoelastic element of measurement
US9895148B2 (en) 2015-03-06 2018-02-20 Ethicon Endo-Surgery, Llc Monitoring speed control and precision incrementing of motor for powered surgical instruments
US10052044B2 (en) 2015-03-06 2018-08-21 Ethicon Llc Time dependent evaluation of sensor data to determine stability, creep, and viscoelastic elements of measures
US10245033B2 (en) 2015-03-06 2019-04-02 Ethicon Llc Surgical instrument comprising a lockable battery housing
US10433844B2 (en) 2015-03-31 2019-10-08 Ethicon Llc Surgical instrument with selectively disengageable threaded drive systems
US9974534B2 (en) * 2015-03-31 2018-05-22 Biomet Sports Medicine, Llc Suture anchor with soft anchor of electrospun fibers
JP7064880B2 (en) 2015-04-01 2022-05-11 イェール ユニバーシティー Iron platinum particles for attachment of biologics on medical implants
JP7094533B2 (en) 2015-04-10 2022-07-04 プレジデント アンド フェローズ オブ ハーバード カレッジ Immune cell capture device and its manufacture and use
AU2016254119A1 (en) 2015-04-29 2017-10-05 Smith & Nephew Inc. Negative pressure wound closure device
AU2016280079B2 (en) 2015-06-17 2021-04-15 Hollister Incorporated Selectively water disintegrable materials and catheters made of such materials
US10368861B2 (en) 2015-06-18 2019-08-06 Ethicon Llc Dual articulation drive system arrangements for articulatable surgical instruments
US10835249B2 (en) 2015-08-17 2020-11-17 Ethicon Llc Implantable layers for a surgical instrument
US10357251B2 (en) 2015-08-26 2019-07-23 Ethicon Llc Surgical staples comprising hardness variations for improved fastening of tissue
BR112018003693B1 (en) 2015-08-26 2022-11-22 Ethicon Llc SURGICAL STAPLE CARTRIDGE FOR USE WITH A SURGICAL STAPPING INSTRUMENT
MX2022009705A (en) 2015-08-26 2022-11-07 Ethicon Llc Surgical staples comprising hardness variations for improved fastening of tissue.
MX2022006189A (en) 2015-09-02 2022-06-16 Ethicon Llc Surgical staple configurations with camming surfaces located between portions supporting surgical staples.
US10251648B2 (en) 2015-09-02 2019-04-09 Ethicon Llc Surgical staple cartridge staple drivers with central support features
US10105139B2 (en) 2015-09-23 2018-10-23 Ethicon Llc Surgical stapler having downstream current-based motor control
US10327769B2 (en) 2015-09-23 2019-06-25 Ethicon Llc Surgical stapler having motor control based on a drive system component
US10085751B2 (en) 2015-09-23 2018-10-02 Ethicon Llc Surgical stapler having temperature-based motor control
US10363036B2 (en) 2015-09-23 2019-07-30 Ethicon Llc Surgical stapler having force-based motor control
US10238386B2 (en) 2015-09-23 2019-03-26 Ethicon Llc Surgical stapler having motor control based on an electrical parameter related to a motor current
US10076326B2 (en) 2015-09-23 2018-09-18 Ethicon Llc Surgical stapler having current mirror-based motor control
US10299878B2 (en) 2015-09-25 2019-05-28 Ethicon Llc Implantable adjunct systems for determining adjunct skew
US11890015B2 (en) 2015-09-30 2024-02-06 Cilag Gmbh International Compressible adjunct with crossing spacer fibers
US10980539B2 (en) 2015-09-30 2021-04-20 Ethicon Llc Implantable adjunct comprising bonded layers
US10603039B2 (en) 2015-09-30 2020-03-31 Ethicon Llc Progressively releasable implantable adjunct for use with a surgical stapling instrument
JP6903009B2 (en) * 2015-09-30 2021-07-14 積水化成品工業株式会社 Porous resin fine particles and their manufacturing method
US10271849B2 (en) 2015-09-30 2019-04-30 Ethicon Llc Woven constructs with interlocked standing fibers
USD836778S1 (en) 2015-10-09 2018-12-25 Tepha, Inc. Three dimensional mastopexy implant
US11471586B2 (en) 2015-12-15 2022-10-18 University Of Massachusetts Negative pressure wound closure devices and methods
US10575991B2 (en) 2015-12-15 2020-03-03 University Of Massachusetts Negative pressure wound closure devices and methods
US10814049B2 (en) 2015-12-15 2020-10-27 University Of Massachusetts Negative pressure wound closure devices and methods
US10265068B2 (en) 2015-12-30 2019-04-23 Ethicon Llc Surgical instruments with separable motors and motor control circuits
US10292704B2 (en) 2015-12-30 2019-05-21 Ethicon Llc Mechanisms for compensating for battery pack failure in powered surgical instruments
US10368865B2 (en) 2015-12-30 2019-08-06 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11752238B2 (en) 2016-02-06 2023-09-12 President And Fellows Of Harvard College Recapitulating the hematopoietic niche to reconstitute immunity
US10433837B2 (en) 2016-02-09 2019-10-08 Ethicon Llc Surgical instruments with multiple link articulation arrangements
US11213293B2 (en) 2016-02-09 2022-01-04 Cilag Gmbh International Articulatable surgical instruments with single articulation link arrangements
BR112018016098B1 (en) 2016-02-09 2023-02-23 Ethicon Llc SURGICAL INSTRUMENT
US10448948B2 (en) 2016-02-12 2019-10-22 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
US11224426B2 (en) 2016-02-12 2022-01-18 Cilag Gmbh International Mechanisms for compensating for drivetrain failure in powered surgical instruments
US10258331B2 (en) 2016-02-12 2019-04-16 Ethicon Llc Mechanisms for compensating for drivetrain failure in powered surgical instruments
KR102594123B1 (en) 2016-03-23 2023-10-26 카나리 메디칼 아이엔씨. Implantable reporting processor for an alert implant
US11191479B2 (en) 2016-03-23 2021-12-07 Canary Medical Inc. Implantable reporting processor for an alert implant
WO2017171260A1 (en) 2016-03-28 2017-10-05 주식회사 엘지화학 Liquid biopolymer, use thereof, and preparation method
US10617413B2 (en) 2016-04-01 2020-04-14 Ethicon Llc Closure system arrangements for surgical cutting and stapling devices with separate and distinct firing shafts
US10314582B2 (en) 2016-04-01 2019-06-11 Ethicon Llc Surgical instrument comprising a shifting mechanism
US10828028B2 (en) 2016-04-15 2020-11-10 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US10426467B2 (en) 2016-04-15 2019-10-01 Ethicon Llc Surgical instrument with detection sensors
US10405859B2 (en) 2016-04-15 2019-09-10 Ethicon Llc Surgical instrument with adjustable stop/start control during a firing motion
US11607239B2 (en) 2016-04-15 2023-03-21 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US10492783B2 (en) 2016-04-15 2019-12-03 Ethicon, Llc Surgical instrument with improved stop/start control during a firing motion
US10456137B2 (en) 2016-04-15 2019-10-29 Ethicon Llc Staple formation detection mechanisms
US11179150B2 (en) 2016-04-15 2021-11-23 Cilag Gmbh International Systems and methods for controlling a surgical stapling and cutting instrument
US10335145B2 (en) 2016-04-15 2019-07-02 Ethicon Llc Modular surgical instrument with configurable operating mode
US10357247B2 (en) 2016-04-15 2019-07-23 Ethicon Llc Surgical instrument with multiple program responses during a firing motion
US20170296173A1 (en) 2016-04-18 2017-10-19 Ethicon Endo-Surgery, Llc Method for operating a surgical instrument
US11317917B2 (en) 2016-04-18 2022-05-03 Cilag Gmbh International Surgical stapling system comprising a lockable firing assembly
US10426469B2 (en) 2016-04-18 2019-10-01 Ethicon Llc Surgical instrument comprising a primary firing lockout and a secondary firing lockout
USD850617S1 (en) 2016-06-24 2019-06-04 Ethicon Llc Surgical fastener cartridge
USD847989S1 (en) 2016-06-24 2019-05-07 Ethicon Llc Surgical fastener cartridge
CN109310431B (en) 2016-06-24 2022-03-04 伊西康有限责任公司 Staple cartridge comprising wire staples and punch staples
US11000278B2 (en) 2016-06-24 2021-05-11 Ethicon Llc Staple cartridge comprising wire staples and stamped staples
USD826405S1 (en) 2016-06-24 2018-08-21 Ethicon Llc Surgical fastener
US11555177B2 (en) 2016-07-13 2023-01-17 President And Fellows Of Harvard College Antigen-presenting cell-mimetic scaffolds and methods for making and using the same
EP3534978B1 (en) 2016-11-03 2021-05-12 ETH Zürich Aligned porous fibrillar scaffold for tissue engineering and surgical application
US11090048B2 (en) 2016-12-21 2021-08-17 Cilag Gmbh International Method for resetting a fuse of a surgical instrument shaft
US10675025B2 (en) 2016-12-21 2020-06-09 Ethicon Llc Shaft assembly comprising separately actuatable and retractable systems
US20180168598A1 (en) 2016-12-21 2018-06-21 Ethicon Endo-Surgery, Llc Staple forming pocket arrangements comprising zoned forming surface grooves
US11191540B2 (en) 2016-12-21 2021-12-07 Cilag Gmbh International Protective cover arrangements for a joint interface between a movable jaw and actuator shaft of a surgical instrument
US11684367B2 (en) 2016-12-21 2023-06-27 Cilag Gmbh International Stepped assembly having and end-of-life indicator
US10687810B2 (en) 2016-12-21 2020-06-23 Ethicon Llc Stepped staple cartridge with tissue retention and gap setting features
US20180168625A1 (en) 2016-12-21 2018-06-21 Ethicon Endo-Surgery, Llc Surgical stapling instruments with smart staple cartridges
US10945727B2 (en) 2016-12-21 2021-03-16 Ethicon Llc Staple cartridge with deformable driver retention features
US10610224B2 (en) 2016-12-21 2020-04-07 Ethicon Llc Lockout arrangements for surgical end effectors and replaceable tool assemblies
US10426471B2 (en) 2016-12-21 2019-10-01 Ethicon Llc Surgical instrument with multiple failure response modes
US10856868B2 (en) 2016-12-21 2020-12-08 Ethicon Llc Firing member pin configurations
US10695055B2 (en) 2016-12-21 2020-06-30 Ethicon Llc Firing assembly comprising a lockout
US10568625B2 (en) 2016-12-21 2020-02-25 Ethicon Llc Staple cartridges and arrangements of staples and staple cavities therein
US10993715B2 (en) 2016-12-21 2021-05-04 Ethicon Llc Staple cartridge comprising staples with different clamping breadths
US10888322B2 (en) 2016-12-21 2021-01-12 Ethicon Llc Surgical instrument comprising a cutting member
US20180168648A1 (en) 2016-12-21 2018-06-21 Ethicon Endo-Surgery, Llc Durability features for end effectors and firing assemblies of surgical stapling instruments
US11419606B2 (en) 2016-12-21 2022-08-23 Cilag Gmbh International Shaft assembly comprising a clutch configured to adapt the output of a rotary firing member to two different systems
US11134942B2 (en) 2016-12-21 2021-10-05 Cilag Gmbh International Surgical stapling instruments and staple-forming anvils
JP6983893B2 (en) 2016-12-21 2021-12-17 エシコン エルエルシーEthicon LLC Lockout configuration for surgical end effectors and replaceable tool assemblies
US10588630B2 (en) 2016-12-21 2020-03-17 Ethicon Llc Surgical tool assemblies with closure stroke reduction features
JP7010956B2 (en) 2016-12-21 2022-01-26 エシコン エルエルシー How to staple tissue
US10568624B2 (en) 2016-12-21 2020-02-25 Ethicon Llc Surgical instruments with jaws that are pivotable about a fixed axis and include separate and distinct closure and firing systems
MX2019007311A (en) 2016-12-21 2019-11-18 Ethicon Llc Surgical stapling systems.
US20180168615A1 (en) 2016-12-21 2018-06-21 Ethicon Endo-Surgery, Llc Method of deforming staples from two different types of staple cartridges with the same surgical stapling instrument
US11040170B2 (en) 2017-05-25 2021-06-22 Tepha, Inc. Continuous formation of tubes of poly-4-hydroxybutyrate and copolymers thereof
US10646220B2 (en) 2017-06-20 2020-05-12 Ethicon Llc Systems and methods for controlling displacement member velocity for a surgical instrument
US11517325B2 (en) 2017-06-20 2022-12-06 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured displacement distance traveled over a specified time interval
USD879809S1 (en) 2017-06-20 2020-03-31 Ethicon Llc Display panel with changeable graphical user interface
US11071554B2 (en) 2017-06-20 2021-07-27 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on magnitude of velocity error measurements
US10390841B2 (en) 2017-06-20 2019-08-27 Ethicon Llc Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation
USD890784S1 (en) 2017-06-20 2020-07-21 Ethicon Llc Display panel with changeable graphical user interface
US10813639B2 (en) 2017-06-20 2020-10-27 Ethicon Llc Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on system conditions
US10881396B2 (en) 2017-06-20 2021-01-05 Ethicon Llc Surgical instrument with variable duration trigger arrangement
USD879808S1 (en) 2017-06-20 2020-03-31 Ethicon Llc Display panel with graphical user interface
US10881399B2 (en) 2017-06-20 2021-01-05 Ethicon Llc Techniques for adaptive control of motor velocity of a surgical stapling and cutting instrument
US11653914B2 (en) 2017-06-20 2023-05-23 Cilag Gmbh International Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument according to articulation angle of end effector
US10980537B2 (en) 2017-06-20 2021-04-20 Ethicon Llc Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified number of shaft rotations
US11090046B2 (en) 2017-06-20 2021-08-17 Cilag Gmbh International Systems and methods for controlling displacement member motion of a surgical stapling and cutting instrument
US10368864B2 (en) 2017-06-20 2019-08-06 Ethicon Llc Systems and methods for controlling displaying motor velocity for a surgical instrument
US10624633B2 (en) 2017-06-20 2020-04-21 Ethicon Llc Systems and methods for controlling motor velocity of a surgical stapling and cutting instrument
US10888321B2 (en) 2017-06-20 2021-01-12 Ethicon Llc Systems and methods for controlling velocity of a displacement member of a surgical stapling and cutting instrument
US10327767B2 (en) 2017-06-20 2019-06-25 Ethicon Llc Control of motor velocity of a surgical stapling and cutting instrument based on angle of articulation
US10779820B2 (en) 2017-06-20 2020-09-22 Ethicon Llc Systems and methods for controlling motor speed according to user input for a surgical instrument
US10307170B2 (en) 2017-06-20 2019-06-04 Ethicon Llc Method for closed loop control of motor velocity of a surgical stapling and cutting instrument
US11382638B2 (en) 2017-06-20 2022-07-12 Cilag Gmbh International Closed loop feedback control of motor velocity of a surgical stapling and cutting instrument based on measured time over a specified displacement distance
US11324503B2 (en) 2017-06-27 2022-05-10 Cilag Gmbh International Surgical firing member arrangements
US10993716B2 (en) 2017-06-27 2021-05-04 Ethicon Llc Surgical anvil arrangements
US10856869B2 (en) 2017-06-27 2020-12-08 Ethicon Llc Surgical anvil arrangements
US10631859B2 (en) 2017-06-27 2020-04-28 Ethicon Llc Articulation systems for surgical instruments
US10772629B2 (en) 2017-06-27 2020-09-15 Ethicon Llc Surgical anvil arrangements
US11266405B2 (en) 2017-06-27 2022-03-08 Cilag Gmbh International Surgical anvil manufacturing methods
US10716614B2 (en) 2017-06-28 2020-07-21 Ethicon Llc Surgical shaft assemblies with slip ring assemblies with increased contact pressure
US10211586B2 (en) 2017-06-28 2019-02-19 Ethicon Llc Surgical shaft assemblies with watertight housings
US11564686B2 (en) 2017-06-28 2023-01-31 Cilag Gmbh International Surgical shaft assemblies with flexible interfaces
US11678880B2 (en) 2017-06-28 2023-06-20 Cilag Gmbh International Surgical instrument comprising a shaft including a housing arrangement
US11259805B2 (en) 2017-06-28 2022-03-01 Cilag Gmbh International Surgical instrument comprising firing member supports
USD851762S1 (en) 2017-06-28 2019-06-18 Ethicon Llc Anvil
US10903685B2 (en) 2017-06-28 2021-01-26 Ethicon Llc Surgical shaft assemblies with slip ring assemblies forming capacitive channels
US10765427B2 (en) 2017-06-28 2020-09-08 Ethicon Llc Method for articulating a surgical instrument
USD854151S1 (en) 2017-06-28 2019-07-16 Ethicon Llc Surgical instrument shaft
US11246592B2 (en) 2017-06-28 2022-02-15 Cilag Gmbh International Surgical instrument comprising an articulation system lockable to a frame
USD906355S1 (en) 2017-06-28 2020-12-29 Ethicon Llc Display screen or portion thereof with a graphical user interface for a surgical instrument
US20190000461A1 (en) 2017-06-28 2019-01-03 Ethicon Llc Surgical cutting and fastening devices with pivotable anvil with a tissue locating arrangement in close proximity to an anvil pivot axis
USD869655S1 (en) 2017-06-28 2019-12-10 Ethicon Llc Surgical fastener cartridge
EP4070740A1 (en) 2017-06-28 2022-10-12 Cilag GmbH International Surgical instrument comprising selectively actuatable rotatable couplers
US10398434B2 (en) 2017-06-29 2019-09-03 Ethicon Llc Closed loop velocity control of closure member for robotic surgical instrument
US10258418B2 (en) 2017-06-29 2019-04-16 Ethicon Llc System for controlling articulation forces
US11007022B2 (en) 2017-06-29 2021-05-18 Ethicon Llc Closed loop velocity control techniques based on sensed tissue parameters for robotic surgical instrument
US10932772B2 (en) 2017-06-29 2021-03-02 Ethicon Llc Methods for closed loop velocity control for robotic surgical instrument
US10898183B2 (en) 2017-06-29 2021-01-26 Ethicon Llc Robotic surgical instrument with closed loop feedback techniques for advancement of closure member during firing
US11944300B2 (en) 2017-08-03 2024-04-02 Cilag Gmbh International Method for operating a surgical system bailout
US11471155B2 (en) 2017-08-03 2022-10-18 Cilag Gmbh International Surgical system bailout
US11304695B2 (en) 2017-08-03 2022-04-19 Cilag Gmbh International Surgical system shaft interconnection
TWI814736B (en) * 2017-08-29 2023-09-11 日商三菱瓦斯化學股份有限公司 Polyester containing 4-hydroxybutyric acid units
WO2019043384A1 (en) * 2017-08-31 2019-03-07 University Of Westminster Stents
EP3676330A1 (en) 2017-08-31 2020-07-08 University of Westminster Nerve conduits
EP3678715A1 (en) 2017-09-06 2020-07-15 Tepha, Inc. Calendered surgical meshes comprising polyhydroxyalkanoates
USD917500S1 (en) 2017-09-29 2021-04-27 Ethicon Llc Display screen or portion thereof with graphical user interface
USD907648S1 (en) 2017-09-29 2021-01-12 Ethicon Llc Display screen or portion thereof with animated graphical user interface
US10765429B2 (en) 2017-09-29 2020-09-08 Ethicon Llc Systems and methods for providing alerts according to the operational state of a surgical instrument
USD907647S1 (en) 2017-09-29 2021-01-12 Ethicon Llc Display screen or portion thereof with animated graphical user interface
US10729501B2 (en) 2017-09-29 2020-08-04 Ethicon Llc Systems and methods for language selection of a surgical instrument
US11399829B2 (en) 2017-09-29 2022-08-02 Cilag Gmbh International Systems and methods of initiating a power shutdown mode for a surgical instrument
US10743872B2 (en) 2017-09-29 2020-08-18 Ethicon Llc System and methods for controlling a display of a surgical instrument
US10796471B2 (en) 2017-09-29 2020-10-06 Ethicon Llc Systems and methods of displaying a knife position for a surgical instrument
JP7239571B2 (en) * 2017-10-24 2023-03-14 デボル，インコーポレイテッド Soft tissue repair implants containing hydroxybutyrate
US11134944B2 (en) 2017-10-30 2021-10-05 Cilag Gmbh International Surgical stapler knife motion controls
US11090075B2 (en) 2017-10-30 2021-08-17 Cilag Gmbh International Articulation features for surgical end effector
US10842490B2 (en) 2017-10-31 2020-11-24 Ethicon Llc Cartridge body design with force reduction based on firing completion
US10779903B2 (en) 2017-10-31 2020-09-22 Ethicon Llc Positive shaft rotation lock activated by jaw closure
US10993807B2 (en) 2017-11-16 2021-05-04 Medtronic Vascular, Inc. Systems and methods for percutaneously supporting and manipulating a septal wall
EP3720514B1 (en) 2017-12-04 2022-04-13 Tepha, Inc. Vacuum membrane thermoformed poly-4-hydroxybutyrate medical implants
US10779825B2 (en) 2017-12-15 2020-09-22 Ethicon Llc Adapters with end effector position sensing and control arrangements for use in connection with electromechanical surgical instruments
US11071543B2 (en) 2017-12-15 2021-07-27 Cilag Gmbh International Surgical end effectors with clamping assemblies configured to increase jaw aperture ranges
US11006955B2 (en) 2017-12-15 2021-05-18 Ethicon Llc End effectors with positive jaw opening features for use with adapters for electromechanical surgical instruments
US10687813B2 (en) 2017-12-15 2020-06-23 Ethicon Llc Adapters with firing stroke sensing arrangements for use in connection with electromechanical surgical instruments
US10828033B2 (en) 2017-12-15 2020-11-10 Ethicon Llc Handheld electromechanical surgical instruments with improved motor control arrangements for positioning components of an adapter coupled thereto
US10869666B2 (en) 2017-12-15 2020-12-22 Ethicon Llc Adapters with control systems for controlling multiple motors of an electromechanical surgical instrument
US10966718B2 (en) 2017-12-15 2021-04-06 Ethicon Llc Dynamic clamping assemblies with improved wear characteristics for use in connection with electromechanical surgical instruments
US11033267B2 (en) 2017-12-15 2021-06-15 Ethicon Llc Systems and methods of controlling a clamping member firing rate of a surgical instrument
US11197670B2 (en) 2017-12-15 2021-12-14 Cilag Gmbh International Surgical end effectors with pivotal jaws configured to touch at their respective distal ends when fully closed
US10743874B2 (en) 2017-12-15 2020-08-18 Ethicon Llc Sealed adapters for use with electromechanical surgical instruments
US10779826B2 (en) 2017-12-15 2020-09-22 Ethicon Llc Methods of operating surgical end effectors
US10743875B2 (en) 2017-12-15 2020-08-18 Ethicon Llc Surgical end effectors with jaw stiffener arrangements configured to permit monitoring of firing member
US10716565B2 (en) 2017-12-19 2020-07-21 Ethicon Llc Surgical instruments with dual articulation drivers
US11045270B2 (en) 2017-12-19 2021-06-29 Cilag Gmbh International Robotic attachment comprising exterior drive actuator
US11020112B2 (en) 2017-12-19 2021-06-01 Ethicon Llc Surgical tools configured for interchangeable use with different controller interfaces
US10729509B2 (en) 2017-12-19 2020-08-04 Ethicon Llc Surgical instrument comprising closure and firing locking mechanism
USD910847S1 (en) 2017-12-19 2021-02-16 Ethicon Llc Surgical instrument assembly
US10835330B2 (en) 2017-12-19 2020-11-17 Ethicon Llc Method for determining the position of a rotatable jaw of a surgical instrument attachment assembly
US11076853B2 (en) 2017-12-21 2021-08-03 Cilag Gmbh International Systems and methods of displaying a knife position during transection for a surgical instrument
US11129680B2 (en) 2017-12-21 2021-09-28 Cilag Gmbh International Surgical instrument comprising a projector
US11311290B2 (en) 2017-12-21 2022-04-26 Cilag Gmbh International Surgical instrument comprising an end effector dampener
US11337691B2 (en) 2017-12-21 2022-05-24 Cilag Gmbh International Surgical instrument configured to determine firing path
USD889654S1 (en) 2018-02-09 2020-07-07 Tepha, Inc. Three dimensional mastopexy implant
US11154393B2 (en) 2018-02-09 2021-10-26 Tepha, Inc. Full contour breast implant
US11759306B2 (en) 2018-03-12 2023-09-19 Bard Shannon Limited In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material
WO2019241227A2 (en) 2018-06-11 2019-12-19 Tepha, Inc. Methods for 3d printing of poly-4-hydroxybutyrate and copolymers
USD892329S1 (en) 2018-07-03 2020-08-04 Tepha, Inc. Three dimensional mastopexy implant
US11083458B2 (en) 2018-08-20 2021-08-10 Cilag Gmbh International Powered surgical instruments with clutching arrangements to convert linear drive motions to rotary drive motions
US10912559B2 (en) 2018-08-20 2021-02-09 Ethicon Llc Reinforced deformable anvil tip for surgical stapler anvil
US10779821B2 (en) 2018-08-20 2020-09-22 Ethicon Llc Surgical stapler anvils with tissue stop features configured to avoid tissue pinch
US10842492B2 (en) 2018-08-20 2020-11-24 Ethicon Llc Powered articulatable surgical instruments with clutching and locking arrangements for linking an articulation drive system to a firing drive system
US11045192B2 (en) 2018-08-20 2021-06-29 Cilag Gmbh International Fabricating techniques for surgical stapler anvils
US11324501B2 (en) 2018-08-20 2022-05-10 Cilag Gmbh International Surgical stapling devices with improved closure members
US11253256B2 (en) 2018-08-20 2022-02-22 Cilag Gmbh International Articulatable motor powered surgical instruments with dedicated articulation motor arrangements
US11291440B2 (en) 2018-08-20 2022-04-05 Cilag Gmbh International Method for operating a powered articulatable surgical instrument
US11039834B2 (en) 2018-08-20 2021-06-22 Cilag Gmbh International Surgical stapler anvils with staple directing protrusions and tissue stability features
USD914878S1 (en) 2018-08-20 2021-03-30 Ethicon Llc Surgical instrument anvil
US11207065B2 (en) 2018-08-20 2021-12-28 Cilag Gmbh International Method for fabricating surgical stapler anvils
US10856870B2 (en) 2018-08-20 2020-12-08 Ethicon Llc Switching arrangements for motor powered articulatable surgical instruments
EP3846868A1 (en) * 2018-09-06 2021-07-14 Bio-On S.p.A. Membrane to re-establish continuity of injured biological tissues
US11779455B2 (en) 2018-10-02 2023-10-10 Tepha, Inc. Medical devices to limit movement of breast implants
ES2956815T3 (en) 2018-10-29 2023-12-28 Tepha Inc Procedures for manufacturing mesh sutures from poly-4-hydroxybutyrate and its copolymers
BR112021011819A2 (en) * 2018-12-18 2021-08-31 International Flavors & Fragrances Inc. MICROCAPSULA COMPOSITION, PROCESS FOR PREPARING A MICROCAPSULA COMPOSITION, AND, CONSUMABLES
EP3897452A4 (en) 2018-12-21 2022-09-07 Tepha, Inc. Resorbable nonwoven pouches for medical device implants
IL285436B2 (en) 2019-02-07 2024-02-01 Biorez Inc Composite scaffold for the repair, reconstruction, and regeneration of soft tissues
US11147551B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11147553B2 (en) 2019-03-25 2021-10-19 Cilag Gmbh International Firing drive arrangements for surgical systems
US11696761B2 (en) 2019-03-25 2023-07-11 Cilag Gmbh International Firing drive arrangements for surgical systems
US11172929B2 (en) 2019-03-25 2021-11-16 Cilag Gmbh International Articulation drive arrangements for surgical systems
US11903581B2 (en) 2019-04-30 2024-02-20 Cilag Gmbh International Methods for stapling tissue using a surgical instrument
US11253254B2 (en) 2019-04-30 2022-02-22 Cilag Gmbh International Shaft rotation actuator on a surgical instrument
US11452528B2 (en) 2019-04-30 2022-09-27 Cilag Gmbh International Articulation actuators for a surgical instrument
US11471157B2 (en) 2019-04-30 2022-10-18 Cilag Gmbh International Articulation control mapping for a surgical instrument
US11432816B2 (en) 2019-04-30 2022-09-06 Cilag Gmbh International Articulation pin for a surgical instrument
US11648009B2 (en) 2019-04-30 2023-05-16 Cilag Gmbh International Rotatable jaw tip for a surgical instrument
US11426251B2 (en) 2019-04-30 2022-08-30 Cilag Gmbh International Articulation directional lights on a surgical instrument
US11246678B2 (en) 2019-06-28 2022-02-15 Cilag Gmbh International Surgical stapling system having a frangible RFID tag
US11259803B2 (en) 2019-06-28 2022-03-01 Cilag Gmbh International Surgical stapling system having an information encryption protocol
US11051807B2 (en) 2019-06-28 2021-07-06 Cilag Gmbh International Packaging assembly including a particulate trap
US11426167B2 (en) 2019-06-28 2022-08-30 Cilag Gmbh International Mechanisms for proper anvil attachment surgical stapling head assembly
US11553971B2 (en) 2019-06-28 2023-01-17 Cilag Gmbh International Surgical RFID assemblies for display and communication
US11523822B2 (en) 2019-06-28 2022-12-13 Cilag Gmbh International Battery pack including a circuit interrupter
US11291451B2 (en) 2019-06-28 2022-04-05 Cilag Gmbh International Surgical instrument with battery compatibility verification functionality
US11627959B2 (en) 2019-06-28 2023-04-18 Cilag Gmbh International Surgical instruments including manual and powered system lockouts
US11684434B2 (en) 2019-06-28 2023-06-27 Cilag Gmbh International Surgical RFID assemblies for instrument operational setting control
US11376098B2 (en) 2019-06-28 2022-07-05 Cilag Gmbh International Surgical instrument system comprising an RFID system
US11298127B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Interational Surgical stapling system having a lockout mechanism for an incompatible cartridge
US11638587B2 (en) 2019-06-28 2023-05-02 Cilag Gmbh International RFID identification systems for surgical instruments
US11224497B2 (en) 2019-06-28 2022-01-18 Cilag Gmbh International Surgical systems with multiple RFID tags
US11464601B2 (en) 2019-06-28 2022-10-11 Cilag Gmbh International Surgical instrument comprising an RFID system for tracking a movable component
US11478241B2 (en) 2019-06-28 2022-10-25 Cilag Gmbh International Staple cartridge including projections
US11771419B2 (en) 2019-06-28 2023-10-03 Cilag Gmbh International Packaging for a replaceable component of a surgical stapling system
US11219455B2 (en) 2019-06-28 2022-01-11 Cilag Gmbh International Surgical instrument including a lockout key
US11241235B2 (en) 2019-06-28 2022-02-08 Cilag Gmbh International Method of using multiple RFID chips with a surgical assembly
US11298132B2 (en) 2019-06-28 2022-04-12 Cilag GmbH Inlernational Staple cartridge including a honeycomb extension
US11497492B2 (en) 2019-06-28 2022-11-15 Cilag Gmbh International Surgical instrument including an articulation lock
US11399837B2 (en) 2019-06-28 2022-08-02 Cilag Gmbh International Mechanisms for motor control adjustments of a motorized surgical instrument
US11660163B2 (en) 2019-06-28 2023-05-30 Cilag Gmbh International Surgical system with RFID tags for updating motor assembly parameters
AU2020392326A1 (en) 2019-11-25 2022-06-23 Tepha, Inc. Breast implant wraps to limit movement of breast implants and related methods
US11234698B2 (en) 2019-12-19 2022-02-01 Cilag Gmbh International Stapling system comprising a clamp lockout and a firing lockout
US11701111B2 (en) 2019-12-19 2023-07-18 Cilag Gmbh International Method for operating a surgical stapling instrument
US11576672B2 (en) 2019-12-19 2023-02-14 Cilag Gmbh International Surgical instrument comprising a closure system including a closure member and an opening member driven by a drive screw
US11504122B2 (en) 2019-12-19 2022-11-22 Cilag Gmbh International Surgical instrument comprising a nested firing member
US11446029B2 (en) 2019-12-19 2022-09-20 Cilag Gmbh International Staple cartridge comprising projections extending from a curved deck surface
US11464512B2 (en) 2019-12-19 2022-10-11 Cilag Gmbh International Staple cartridge comprising a curved deck surface
US11304696B2 (en) 2019-12-19 2022-04-19 Cilag Gmbh International Surgical instrument comprising a powered articulation system
US11911032B2 (en) 2019-12-19 2024-02-27 Cilag Gmbh International Staple cartridge comprising a seating cam
US11607219B2 (en) 2019-12-19 2023-03-21 Cilag Gmbh International Staple cartridge comprising a detachable tissue cutting knife
US11844520B2 (en) 2019-12-19 2023-12-19 Cilag Gmbh International Staple cartridge comprising driver retention members
US11931033B2 (en) 2019-12-19 2024-03-19 Cilag Gmbh International Staple cartridge comprising a latch lockout
US11291447B2 (en) 2019-12-19 2022-04-05 Cilag Gmbh International Stapling instrument comprising independent jaw closing and staple firing systems
US11559304B2 (en) 2019-12-19 2023-01-24 Cilag Gmbh International Surgical instrument comprising a rapid closure mechanism
US11529139B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Motor driven surgical instrument
US11529137B2 (en) 2019-12-19 2022-12-20 Cilag Gmbh International Staple cartridge comprising driver retention members
BR122023022155A2 (en) 2020-03-23 2024-02-20 Bard Shannon Limited IMPLANTABLE PROSTHESIS COMPRISING A BODY OF BIOCOMPATIBLE MATERIAL
USD966512S1 (en) 2020-06-02 2022-10-11 Cilag Gmbh International Staple cartridge
USD975850S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
USD975851S1 (en) 2020-06-02 2023-01-17 Cilag Gmbh International Staple cartridge
USD975278S1 (en) 2020-06-02 2023-01-10 Cilag Gmbh International Staple cartridge
USD967421S1 (en) 2020-06-02 2022-10-18 Cilag Gmbh International Staple cartridge
USD976401S1 (en) 2020-06-02 2023-01-24 Cilag Gmbh International Staple cartridge
USD974560S1 (en) 2020-06-02 2023-01-03 Cilag Gmbh International Staple cartridge
US11883024B2 (en) 2020-07-28 2024-01-30 Cilag Gmbh International Method of operating a surgical instrument
US11534286B1 (en) * 2020-08-11 2022-12-27 Simon B. Rayhanabad Method of using an endovascular stent-graft with an extra vascular extension
JPWO2022092014A1 (en) 2020-10-26 2022-05-05
USD1013170S1 (en) 2020-10-29 2024-01-30 Cilag Gmbh International Surgical instrument assembly
US11931025B2 (en) 2020-10-29 2024-03-19 Cilag Gmbh International Surgical instrument comprising a releasable closure drive lock
US11534259B2 (en) 2020-10-29 2022-12-27 Cilag Gmbh International Surgical instrument comprising an articulation indicator
US11896217B2 (en) 2020-10-29 2024-02-13 Cilag Gmbh International Surgical instrument comprising an articulation lock
US11452526B2 (en) 2020-10-29 2022-09-27 Cilag Gmbh International Surgical instrument comprising a staged voltage regulation start-up system
US11779330B2 (en) 2020-10-29 2023-10-10 Cilag Gmbh International Surgical instrument comprising a jaw alignment system
US11844518B2 (en) 2020-10-29 2023-12-19 Cilag Gmbh International Method for operating a surgical instrument
US11617577B2 (en) 2020-10-29 2023-04-04 Cilag Gmbh International Surgical instrument comprising a sensor configured to sense whether an articulation drive of the surgical instrument is actuatable
US11517390B2 (en) 2020-10-29 2022-12-06 Cilag Gmbh International Surgical instrument comprising a limited travel switch
US11717289B2 (en) 2020-10-29 2023-08-08 Cilag Gmbh International Surgical instrument comprising an indicator which indicates that an articulation drive is actuatable
USD980425S1 (en) 2020-10-29 2023-03-07 Cilag Gmbh International Surgical instrument assembly
US11737751B2 (en) 2020-12-02 2023-08-29 Cilag Gmbh International Devices and methods of managing energy dissipated within sterile barriers of surgical instrument housings
US11890010B2 (en) 2020-12-02 2024-02-06 Cllag GmbH International Dual-sided reinforced reload for surgical instruments
US11653920B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Powered surgical instruments with communication interfaces through sterile barrier
US11744581B2 (en) 2020-12-02 2023-09-05 Cilag Gmbh International Powered surgical instruments with multi-phase tissue treatment
US11944296B2 (en) 2020-12-02 2024-04-02 Cilag Gmbh International Powered surgical instruments with external connectors
US11678882B2 (en) 2020-12-02 2023-06-20 Cilag Gmbh International Surgical instruments with interactive features to remedy incidental sled movements
US11849943B2 (en) 2020-12-02 2023-12-26 Cilag Gmbh International Surgical instrument with cartridge release mechanisms
US11627960B2 (en) 2020-12-02 2023-04-18 Cilag Gmbh International Powered surgical instruments with smart reload with separately attachable exteriorly mounted wiring connections
US11653915B2 (en) 2020-12-02 2023-05-23 Cilag Gmbh International Surgical instruments with sled location detection and adjustment features
CN112807485A (en) * 2020-12-23 2021-05-18 青岛科技大学 Injectable poly (4-hydroxybutyrate) (P4HB) porous microsphere preparation without stem cell and growth factor load
US11751869B2 (en) 2021-02-26 2023-09-12 Cilag Gmbh International Monitoring of multiple sensors over time to detect moving characteristics of tissue
US11950777B2 (en) 2021-02-26 2024-04-09 Cilag Gmbh International Staple cartridge comprising an information access control system
US11950779B2 (en) 2021-02-26 2024-04-09 Cilag Gmbh International Method of powering and communicating with a staple cartridge
US11749877B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Stapling instrument comprising a signal antenna
US11925349B2 (en) 2021-02-26 2024-03-12 Cilag Gmbh International Adjustment to transfer parameters to improve available power
US11793514B2 (en) 2021-02-26 2023-10-24 Cilag Gmbh International Staple cartridge comprising sensor array which may be embedded in cartridge body
US11812964B2 (en) 2021-02-26 2023-11-14 Cilag Gmbh International Staple cartridge comprising a power management circuit
US11723657B2 (en) 2021-02-26 2023-08-15 Cilag Gmbh International Adjustable communication based on available bandwidth and power capacity
US11730473B2 (en) 2021-02-26 2023-08-22 Cilag Gmbh International Monitoring of manufacturing life-cycle
US11701113B2 (en) 2021-02-26 2023-07-18 Cilag Gmbh International Stapling instrument comprising a separate power antenna and a data transfer antenna
US11696757B2 (en) 2021-02-26 2023-07-11 Cilag Gmbh International Monitoring of internal systems to detect and track cartridge motion status
US11744583B2 (en) 2021-02-26 2023-09-05 Cilag Gmbh International Distal communication array to tune frequency of RF systems
US11826012B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Stapling instrument comprising a pulsed motor-driven firing rack
US11806011B2 (en) 2021-03-22 2023-11-07 Cilag Gmbh International Stapling instrument comprising tissue compression systems
US11826042B2 (en) 2021-03-22 2023-11-28 Cilag Gmbh International Surgical instrument comprising a firing drive including a selectable leverage mechanism
US11723658B2 (en) 2021-03-22 2023-08-15 Cilag Gmbh International Staple cartridge comprising a firing lockout
US11737749B2 (en) 2021-03-22 2023-08-29 Cilag Gmbh International Surgical stapling instrument comprising a retraction system
US11759202B2 (en) 2021-03-22 2023-09-19 Cilag Gmbh International Staple cartridge comprising an implantable layer
US11717291B2 (en) 2021-03-22 2023-08-08 Cilag Gmbh International Staple cartridge comprising staples configured to apply different tissue compression
US11744603B2 (en) 2021-03-24 2023-09-05 Cilag Gmbh International Multi-axis pivot joints for surgical instruments and methods for manufacturing same
US11903582B2 (en) 2021-03-24 2024-02-20 Cilag Gmbh International Leveraging surfaces for cartridge installation
US11832816B2 (en) 2021-03-24 2023-12-05 Cilag Gmbh International Surgical stapling assembly comprising nonplanar staples and planar staples
US11849944B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Drivers for fastener cartridge assemblies having rotary drive screws
US11786239B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Surgical instrument articulation joint arrangements comprising multiple moving linkage features
US11849945B2 (en) 2021-03-24 2023-12-26 Cilag Gmbh International Rotary-driven surgical stapling assembly comprising eccentrically driven firing member
US11944336B2 (en) 2021-03-24 2024-04-02 Cilag Gmbh International Joint arrangements for multi-planar alignment and support of operational drive shafts in articulatable surgical instruments
US11786243B2 (en) 2021-03-24 2023-10-17 Cilag Gmbh International Firing members having flexible portions for adapting to a load during a surgical firing stroke
US11793516B2 (en) 2021-03-24 2023-10-24 Cilag Gmbh International Surgical staple cartridge comprising longitudinal support beam
US11896218B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Method of using a powered stapling device
US11857183B2 (en) 2021-03-24 2024-01-02 Cilag Gmbh International Stapling assembly components having metal substrates and plastic bodies
US11896219B2 (en) 2021-03-24 2024-02-13 Cilag Gmbh International Mating features between drivers and underside of a cartridge deck
US11826047B2 (en) 2021-05-28 2023-11-28 Cilag Gmbh International Stapling instrument comprising jaw mounts
AU2022299275A1 (en) 2021-06-21 2024-01-18 Beiersdorf Ag Biodegradable pressure-sensitive adhesive
US11877745B2 (en) 2021-10-18 2024-01-23 Cilag Gmbh International Surgical stapling assembly having longitudinally-repeating staple leg clusters
US11957337B2 (en) 2021-10-18 2024-04-16 Cilag Gmbh International Surgical stapling assembly with offset ramped drive surfaces
US11937816B2 (en) 2021-10-28 2024-03-26 Cilag Gmbh International Electrical lead arrangements for surgical instruments
CN115969581B (en) * 2023-03-17 2023-05-30 四川大学 Stacked ultrathin pre-formed bone plate kit for jaw increment and use method thereof

Family Cites Families (274)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3739773A (en) 1963-10-31 1973-06-19 American Cyanamid Co Polyglycolic acid prosthetic devices
US3875937A (en) 1963-10-31 1975-04-08 American Cyanamid Co Surgical dressings of absorbable polymers
US3598123A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3797494A (en) * 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3598122A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
BE758156R (en) 1970-05-13 1971-04-28 Ethicon Inc ABSORBABLE SUTURE ELEMENT AND ITS
US3797499A (en) 1970-05-13 1974-03-19 Ethicon Inc Polylactide fabric graphs for surgical implantation
US3731683A (en) * 1971-06-04 1973-05-08 Alza Corp Bandage for the controlled metering of topical drugs to the skin
US3982543A (en) * 1973-04-24 1976-09-28 American Cyanamid Company Reducing capillarity of polyglycolic acid sutures
GB1519139A (en) 1974-06-18 1978-07-26 Crock H V And Pericic L L securing elongate members to structurs more especially in surgical procedures
US3978855A (en) 1975-01-17 1976-09-07 Ionics Lyo Products Company Polyurethane foam surgical dressing
US4031894A (en) * 1975-12-08 1977-06-28 Alza Corporation Bandage for transdermally administering scopolamine to prevent nausea
US4052988A (en) 1976-01-12 1977-10-11 Ethicon, Inc. Synthetic absorbable surgical devices of poly-dioxanone
US4205399A (en) * 1977-06-13 1980-06-03 Ethicon, Inc. Synthetic absorbable surgical devices of poly(alkylene oxalates)
US4201211A (en) * 1977-07-12 1980-05-06 Alza Corporation Therapeutic system for administering clonidine transdermally
US4217890A (en) 1978-11-03 1980-08-19 Owens Milton L Surgical sling for positioning a harvested kidney during surgical reattachment
US4286592A (en) * 1980-02-04 1981-09-01 Alza Corporation Therapeutic system for administering drugs to the skin
US4314557A (en) * 1980-05-19 1982-02-09 Alza Corporation Dissolution controlled active agent dispenser
US4379454A (en) * 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
US4849226A (en) * 1981-06-29 1989-07-18 Alza Corporation Method for increasing oxygen supply by administering vasodilator
US4501269A (en) 1981-12-11 1985-02-26 Washington State University Research Foundation, Inc. Process for fusing bone joints
US4441496A (en) 1982-02-08 1984-04-10 Ethicon, Inc. Copolymers of p-dioxanone and 2,5-morpholinediones and surgical devices formed therefrom having accelerated absorption characteristics
US4435180A (en) * 1982-05-25 1984-03-06 Alza Corporation Elastomeric active agent delivery system and method of use
EP0104731B1 (en) * 1982-08-27 1987-11-25 Imperial Chemical Industries Plc 3-hydroxybutyrate polymers
US4559222A (en) 1983-05-04 1985-12-17 Alza Corporation Matrix composition for transdermal therapeutic system
US4856188A (en) * 1984-10-12 1989-08-15 Drug Delivery Systems Inc. Method for making disposable and/or replenishable transdermal drug applicators
EP0145233B2 (en) 1983-11-23 1991-11-06 Imperial Chemical Industries Plc Separation processfor a 3-hydroxybutyrate polymer
US4633873A (en) 1984-04-26 1987-01-06 American Cyanamid Company Surgical repair mesh
US4704282A (en) 1984-06-29 1987-11-03 Alza Corporation Transdermal therapeutic system having improved delivery characteristics
US4588580B2 (en) * 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
GB8419745D0 (en) 1984-08-02 1984-09-05 Smith & Nephew Ass Wound dressing
GB8424950D0 (en) * 1984-10-03 1984-11-07 Ici Plc Non-woven fibrous materials
US4573995A (en) * 1984-10-09 1986-03-04 Alza Corporation Transdermal therapeutic systems for the administration of naloxone, naltrexone and nalbuphine
GB2166354B (en) 1984-10-10 1987-12-09 Ici Plc Wound dressings
US4646741A (en) 1984-11-09 1987-03-03 Ethicon, Inc. Surgical fastener made from polymeric blends
US4580794A (en) * 1984-11-16 1986-04-08 Jamak, Inc. Silicon rubber gasket and material
US5522894A (en) 1984-12-14 1996-06-04 Draenert; Klaus Bone replacement material made of absorbable beads
US4648978A (en) * 1985-04-24 1987-03-10 American Sterilizer Company Process for the continuous preparation of sterile, depyrogenated solutions
US4683878A (en) 1985-04-29 1987-08-04 Kirschner Medical Corporation Osteosynthetic fixation plate
US4645502A (en) * 1985-05-03 1987-02-24 Alza Corporation Transdermal delivery of highly ionized fat insoluble drugs
US4655221A (en) 1985-05-06 1987-04-07 American Cyanamid Company Method of using a surgical repair mesh
FI75493C (en) * 1985-05-08 1988-07-11 Materials Consultants Oy SJAELVARMERAT ABSORBERBART PURCHASING SYNTHESIS.
US4743236A (en) 1985-05-17 1988-05-10 Plastronics, Inc. Combination urine meter and urinary drainage bag and the method of use
US4889119A (en) 1985-07-17 1989-12-26 Ethicon, Inc. Surgical fastener made from glycolide-rich polymer blends
US4741337A (en) 1985-07-17 1988-05-03 Ethicon, Inc. Surgical fastener made from glycolide-rich polymer blends
AU603076B2 (en) 1985-12-09 1990-11-08 W.R. Grace & Co.-Conn. Polymeric products and their manufacture
US4792336A (en) 1986-03-03 1988-12-20 American Cyanamid Company Flat braided ligament or tendon implant device having texturized yarns
US4758234A (en) * 1986-03-20 1988-07-19 Norman Orentreich High viscosity fluid delivery system
US4664655A (en) * 1986-03-20 1987-05-12 Norman Orentreich High viscosity fluid delivery system
US4895148A (en) 1986-05-20 1990-01-23 Concept, Inc. Method of joining torn parts of bodily tissue in vivo with a biodegradable tack member
US4924865A (en) 1986-05-20 1990-05-15 Concept, Inc. Repair tack for bodily tissue
US5032638A (en) * 1986-09-05 1991-07-16 American Cyanamid Company Bioabsorbable coating for a surgical device
US4711241A (en) 1986-09-05 1987-12-08 American Cyanamid Company Surgical filament coating
US4908027A (en) * 1986-09-12 1990-03-13 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US4840626A (en) 1986-09-29 1989-06-20 Johnson & Johnson Patient Care, Inc. Heparin-containing adhesion prevention barrier and process
US5019087A (en) 1986-10-06 1991-05-28 American Biomaterials Corporation Nerve regeneration conduit
JPH0725689B2 (en) * 1986-10-07 1995-03-22 中外製薬株式会社 Sustained-release preparation containing granulocyte colony-stimulating factor
US5041138A (en) 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
US5736372A (en) 1986-11-20 1998-04-07 Massachusetts Institute Of Technology Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
NL8603073A (en) 1986-12-02 1988-07-01 Rijksuniversiteit METHOD FOR PREPARING POLYESTERS BY FERMENTATION; METHOD FOR PREPARING OPTICALLY ACTIVE CARBONIC ACIDS AND ESTERS; POLYESTER INCLUDING PRODUCTS.
US4816258A (en) * 1987-02-26 1989-03-28 Alza Corporation Transdermal contraceptive formulations
US4788062A (en) 1987-02-26 1988-11-29 Alza Corporation Transdermal administration of progesterone, estradiol esters, and mixtures thereof
US5059211A (en) 1987-06-25 1991-10-22 Duke University Absorbable vascular stent
US5480794A (en) 1987-06-29 1996-01-02 Massachusetts Institute Of Technology And Metabolix, Inc. Overproduction and purification of soluble PHA synthase
US5250430A (en) 1987-06-29 1993-10-05 Massachusetts Institute Of Technology Polyhydroxyalkanoate polymerase
US5229279A (en) 1987-06-29 1993-07-20 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
US5245023A (en) 1987-06-29 1993-09-14 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
SE8802414D0 (en) 1988-06-27 1988-06-28 Astra Meditec Ab NEW SURGICAL MATERIAL
US4943435A (en) * 1987-10-05 1990-07-24 Pharmetrix Corporation Prolonged activity nicotine patch
JPH01265970A (en) 1988-04-19 1989-10-24 Shiseido Co Ltd Collagen water solution or water dispersion solution including hyaluronic acid
US4955893A (en) 1988-05-09 1990-09-11 Massachusetts Institute Of Technologh Prosthesis for promotion of nerve regeneration
US5502158A (en) * 1988-08-08 1996-03-26 Ecopol, Llc Degradable polymer composition
US5250584A (en) 1988-08-31 1993-10-05 G-C Dental Industrial Corp. Periodontium-regenerative materials
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5085629A (en) 1988-10-06 1992-02-04 Medical Engineering Corporation Biodegradable stent
US4961740B1 (en) 1988-10-17 1997-01-14 Surgical Dynamics Inc V-thread fusion cage and method of fusing a bone joint
US5306500A (en) 1988-11-21 1994-04-26 Collagen Corporation Method of augmenting tissue with collagen-polymer conjugates
US5700479A (en) 1988-12-23 1997-12-23 Guidor Ab Surgical element and method for selective tissue regeneration
US4988358A (en) 1988-12-28 1991-01-29 Eppley Barry L Method for promoting hard tissue growth and repair in mammals
US5092883A (en) 1988-12-28 1992-03-03 Eppley Barry L Method for promoting soft connective tissue growth and repair in mammals
US5059206A (en) 1989-04-12 1991-10-22 Winters Thomas F Method and apparatus for repairing a tear in a knee meniscus
US5026381A (en) 1989-04-20 1991-06-25 Colla-Tec, Incorporated Multi-layered, semi-permeable conduit for nerve regeneration comprised of type 1 collagen, its method of manufacture and a method of nerve regeneration using said conduit
US5041100A (en) * 1989-04-28 1991-08-20 Cordis Corporation Catheter and hydrophilic, friction-reducing coating thereon
US5062845A (en) 1989-05-10 1991-11-05 Spine-Tech, Inc. Method of making an intervertebral reamer
US4927421A (en) 1989-05-15 1990-05-22 Marlowe Goble E Process of endosteal fixation of a ligament
US5100422A (en) 1989-05-26 1992-03-31 Impra, Inc. Blood vessel patch
US5104400A (en) 1989-05-26 1992-04-14 Impra, Inc. Blood vessel patch
US5077049A (en) 1989-07-24 1991-12-31 Vipont Pharmaceutical, Inc. Biodegradable system for regenerating the periodontium
US5002067A (en) * 1989-08-23 1991-03-26 Medtronic, Inc. Medical electrical lead employing improved penetrating electrode
US4936848A (en) 1989-09-22 1990-06-26 Bagby George W Implant for vertebrae
EP0423484B1 (en) * 1989-10-16 1993-11-03 PCD-Polymere Gesellschaft m.b.H. Tablet with sustained release
US5271961A (en) 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
DE3937649A1 (en) * 1989-11-11 1991-05-16 Boehringer Ingelheim Kg POLYESTER BASED ON 4-HYDROXYALKANSAURES AND METHOD FOR THE PRODUCTION THEREOF
JPH0662839B2 (en) * 1989-11-14 1994-08-17 工業技術院長 Microbial degradable plastic molding and method for producing the same
US5705187A (en) 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
US5141522A (en) 1990-02-06 1992-08-25 American Cyanamid Company Composite material having absorbable and non-absorbable components for use with mammalian tissue
US5035713A (en) 1990-02-12 1991-07-30 Orthopaedic Research Institute, Inc. Surgical implants incorporating re-entrant material
EP0452111B1 (en) * 1990-04-13 1998-07-15 Takeda Chemical Industries, Ltd. Biodegradable high-molecular polymers, production and use thereof
US5021059A (en) 1990-05-07 1991-06-04 Kensey Nash Corporation Plug device with pulley for sealing punctures in tissue and methods of use
US5171308A (en) 1990-05-11 1992-12-15 E. I. Du Pont De Nemours And Company Polyesters and their use in compostable products such as disposable diapers
AU636481B2 (en) 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5593425A (en) 1990-06-28 1997-01-14 Peter M. Bonutti Surgical devices assembled using heat bonable materials
US5163960A (en) 1990-06-28 1992-11-17 Bonutti Peter M Surgical devices assembled using heat bondable materials
US5269809A (en) 1990-07-02 1993-12-14 American Cyanamid Company Locking mechanism for use with a slotted suture anchor
US5041129A (en) 1990-07-02 1991-08-20 Acufex Microsurgical, Inc. Slotted suture anchor and method of anchoring a suture
US5252701A (en) 1990-07-06 1993-10-12 American Cyanamid Company Segmented absorbable copolymer
JPH06503732A (en) 1990-09-04 1994-04-28 スミス アンド ネフュー インコーポレイテッド surgical screws
US5824658A (en) 1990-09-18 1998-10-20 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
US5725529A (en) 1990-09-25 1998-03-10 Innovasive Devices, Inc. Bone fastener
AU653752B2 (en) 1990-09-25 1994-10-13 Ethicon Inc. Bone fastener
US5147387A (en) 1990-10-10 1992-09-15 W. L. Gore & Associates, Inc. Process of implanting a prosthetic sheet repair material
US5626863A (en) 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5222963A (en) 1991-01-17 1993-06-29 Ethicon, Inc. Pull-through circular anastomosic intraluminal stapler with absorbable fastener means
US5853746A (en) 1991-01-31 1998-12-29 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier
GB9102660D0 (en) 1991-02-07 1991-03-27 Ultra Lab Ltd Wound dressing materials
IT1247157B (en) 1991-02-11 1994-12-12 Fidia Spa BIODEGRADABLE AND BIOABSORBABLE GUIDE CHANNELS TO BE USED FOR NERVE REGENERATION.
US5690675A (en) 1991-02-13 1997-11-25 Fusion Medical Technologies, Inc. Methods for sealing of staples and other fasteners in tissue
CA2064410A1 (en) * 1991-04-01 1992-10-02 Masanobu Ajioka Degradable foam and use of same
GB9107628D0 (en) 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
DE4113984C2 (en) * 1991-04-29 2002-05-08 Koehler Chemie Dr Franz Salts of 4-hydroxy butyric acid
FR2676927B1 (en) * 1991-05-29 1995-06-23 Ibf MICROSPHERES FOR USE IN THERAPEUTIC VASCULAR OCCLUSIONS AND INJECTABLE SOLUTIONS CONTAINING THEM.
US5116337A (en) 1991-06-27 1992-05-26 Johnson Lanny L Fixation screw and method for ligament reconstruction
US5236431A (en) * 1991-07-22 1993-08-17 Synthes Resorbable fixation device with controlled stiffness for treating bodily material in vivo and introducer therefor
US5329846A (en) 1991-08-12 1994-07-19 Bonutti Peter M Tissue press and system
US5275601A (en) 1991-09-03 1994-01-04 Synthes (U.S.A) Self-locking resorbable screws and plates for internal fixation of bone fractures and tendon-to-bone attachment
JP2777757B2 (en) 1991-09-17 1998-07-23 鐘淵化学工業株式会社 Copolymer and method for producing the same
JPH05131023A (en) * 1991-11-14 1993-05-28 Terumo Corp Material buried in organism and medical tool using said material
DE69229261T2 (en) * 1991-09-27 1999-11-04 Terumo Corp FLEXIBLE PART FOR MEDICAL USE
US5464450A (en) 1991-10-04 1995-11-07 Scimed Lifesystems Inc. Biodegradable drug delivery vascular stent
US5500013A (en) 1991-10-04 1996-03-19 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
WO1993006792A1 (en) 1991-10-04 1993-04-15 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
US5676689A (en) 1991-11-08 1997-10-14 Kensey Nash Corporation Hemostatic puncture closure system including vessel location device and method of use
WO1993010715A2 (en) 1991-12-03 1993-06-10 Vesitec Medical, Inc. Surgical treatment of stress urinary incontinence
CA2181673C (en) 1991-12-03 2000-06-13 Theodore V. Benderev Suture passer
US5439467A (en) 1991-12-03 1995-08-08 Vesica Medical, Inc. Suture passer
US5240530A (en) * 1992-02-10 1993-08-31 Tennessee Valley Performance Products, Inc. Carpet and techniques for making and recycling same
AU672596B2 (en) 1992-02-14 1996-10-10 Smith & Nephew, Inc. Polymeric screws and coatings for surgical uses
US5876452A (en) 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
US5425733A (en) 1992-02-19 1995-06-20 Arthrex, Inc. Interference screw with rounded back end and cannulated sheath for endosteal fixation of ligaments
US5211647A (en) 1992-02-19 1993-05-18 Arthrex Inc. Interference screw and cannulated sheath for endosteal fixation of ligaments
US5204382A (en) * 1992-02-28 1993-04-20 Collagen Corporation Injectable ceramic compositions and methods for their preparation and use
WO1993017635A1 (en) 1992-03-04 1993-09-16 C.R. Bard, Inc. Composite prosthesis and method for limiting the incidence of postoperative adhesions
CH689767A5 (en) * 1992-03-24 1999-10-15 Balzers Hochvakuum Process for Werkstueckbehandlung in a Vakuumatmosphaere and vacuum treatment system.
JPH07505813A (en) 1992-04-24 1995-06-29 オステオテク，インコーポレイテッド Tissue adhesion prevention device
US6312442B1 (en) 1992-06-02 2001-11-06 General Surgical Innovations, Inc. Method for developing an anatomic space for laparoscopic hernia repair
US5540711A (en) 1992-06-02 1996-07-30 General Surgical Innovations, Inc. Apparatus and method for developing an anatomic space for laparoscopic procedures with laparoscopic visualization
US5939467A (en) 1992-06-26 1999-08-17 The Procter & Gamble Company Biodegradable polymeric compositions and products thereof
US5703160A (en) 1992-07-15 1997-12-30 Solvay S.A. Biodegradable moulding compositions comprising a starch, a biodegradable polyester, and a salt of a hydroxycarboxylic acid
US5373860A (en) 1992-08-25 1994-12-20 Catone; Guy A. Apparatus for and method of contouring plates for bone fixation
US5327914A (en) 1992-09-02 1994-07-12 Shlain Leonard M Method and devices for use in surgical gastroplastic procedure
US5345949A (en) 1992-09-02 1994-09-13 Shlain Leonard M Methods for use in surgical gastroplastic procedure
US5700485A (en) * 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
US5278256A (en) * 1992-09-16 1994-01-11 E. I. Du Pont De Nemours And Company Rapidly degradable poly (hydroxyacid) compositions
US5348026A (en) 1992-09-29 1994-09-20 Smith & Nephew Richards Inc. Osteoinductive bone screw
GB9223350D0 (en) * 1992-11-06 1992-12-23 Ici Plc Polymer composition
GB9223351D0 (en) * 1992-11-06 1992-12-23 Ici Plc Polyesters
US5716395A (en) 1992-12-11 1998-02-10 W.L. Gore & Associates, Inc. Prosthetic vascular graft
US5628782A (en) 1992-12-11 1997-05-13 W. L. Gore & Associates, Inc. Method of making a prosthetic vascular graft
JP3263710B2 (en) * 1992-12-11 2002-03-11 高砂香料工業株式会社 Biodegradable optically active polymer and method for producing the same
US5443458A (en) 1992-12-22 1995-08-22 Advanced Cardiovascular Systems, Inc. Multilayered biodegradable stent and method of manufacture
US5468253A (en) 1993-01-21 1995-11-21 Ethicon, Inc. Elastomeric medical device
CA2114290C (en) 1993-01-27 2006-01-10 Nagabushanam Totakura Post-surgical anti-adhesion device
US5368602A (en) 1993-02-11 1994-11-29 De La Torre; Roger A. Surgical mesh with semi-rigid border members
US5433996A (en) 1993-02-18 1995-07-18 W. L. Gore & Associates, Inc. Laminated patch tissue repair sheet material
WO1994019170A1 (en) 1993-02-18 1994-09-01 W.L. Gore & Associates, Inc. Macroscopically perforated porous polytetrafluoroethylene materials
US5797960A (en) 1993-02-22 1998-08-25 Stevens; John H. Method and apparatus for thoracoscopic intracardiac procedures
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5412067A (en) * 1993-05-10 1995-05-02 Mitsui Toatsu Chemicals, Inc. Preparation process of polyester
GB9311402D0 (en) * 1993-06-02 1993-07-21 Zeneca Ltd Processing of polyesters
US5874040A (en) * 1993-06-02 1999-02-23 Monsanto Company Processing of polyesters
CA2164215A1 (en) 1993-06-04 1994-12-22 Gregory James Roger Surgical screw and washer
JP3243334B2 (en) * 1993-06-10 2002-01-07 テルモ株式会社 Hydroxyalkanoate polymer composition
US5632748A (en) 1993-06-14 1997-05-27 Linvatec Corporation Endosteal anchoring device for urging a ligament against a bone surface
AU7396294A (en) * 1993-06-25 1995-01-24 Alza Corporation Incorporating poly-n-vinyl amide in a transdermal system
US5994341A (en) 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
JPH09504308A (en) 1993-07-23 1997-04-28 マサチューセッツ インスティチュート オブ テクノロジー Non-linear hydrophilic-hydrophobic multiblock copolymer nanoparticles and microparticles
US5397332A (en) 1993-09-02 1995-03-14 Ethicon, Inc. Surgical mesh applicator
US5455041A (en) 1993-09-13 1995-10-03 Research Foundation Of State University Of New York At Buffalo Method for inducing periodontal tissue regeneration
GB2282328B (en) 1993-09-29 1997-10-08 Johnson & Johnson Medical Absorbable structures for ligament and tendon repair
US5393594A (en) 1993-10-06 1995-02-28 United States Surgical Corporation Absorbable non-woven fabric
JPH083333A (en) * 1994-06-22 1996-01-09 Tokuyama Corp Melt-extruded film of biodegradable aliphatic polyester and bag comprising the same
US5423857A (en) 1993-11-02 1995-06-13 Ethicon, Inc. Three piece surgical staple
US5814599A (en) 1995-08-04 1998-09-29 Massachusetts Insitiute Of Technology Transdermal delivery of encapsulated drugs
US5792106A (en) 1993-12-02 1998-08-11 Scimed Life Systems, Inc. In situ stent forming catheter
US5417692A (en) 1994-01-04 1995-05-23 Goble; E. Marlowe Bone fixation and fusion system
AU1560095A (en) * 1994-01-06 1995-08-01 Metabolix, Inc. Methods for synthesizing oligomers containing hydroxy acid units
AU1011595A (en) 1994-01-13 1995-07-20 Ethicon Inc. Spiral surgical tack
US5423821A (en) 1994-01-18 1995-06-13 Pasque; Michael K. Sternal closure device
SG49096A1 (en) 1994-01-28 1998-05-18 Procter & Gamble Biodegradable 3-polyhydtoxybuyrate/3- polyhydroxyhexanoate copolymer films
ID23491A (en) 1994-01-28 1995-09-07 Procter & Gamble COOPOLYMERS WHICH CAN BE DIODODEGRADED AND PLASTIC MATERIALS CONTAINED FROM CO-COLLIMERS WHICH CAN BE DIBIODEGRADED
ZA95627B (en) 1994-01-28 1995-10-05 Procter & Gamble Biodegradable copolymers and plastic articles comprising biodegradable copolymers
ATE314410T1 (en) 1994-01-28 2006-01-15 Procter & Gamble BIODEGRADABLE COPOLYMERS AND PLASTIC OBJECTS MADE OF BIODEGRADABLE 3-HYDROXYHEXANOATE COPOLYMERS
US5626611A (en) 1994-02-10 1997-05-06 United States Surgical Corporation Composite bioabsorbable materials and surgical articles made therefrom
ATE217653T1 (en) 1994-02-28 2002-06-15 Procter & Gamble STIRRING PROCESS FOR PRODUCING BIODEGRADABLE FIBRILES
JPH07275344A (en) * 1994-04-05 1995-10-24 Nippon Zeon Co Ltd Medical material for soft tissue
US5584836A (en) 1994-04-07 1996-12-17 Smith & Nephew Richards, Inc. Cannulated medical suture anchor
WO1995028124A2 (en) 1994-04-08 1995-10-26 Atrix Laboratories, Inc. An adjunctive polymer system for use with medical device
FR2719012B1 (en) 1994-04-22 1996-07-12 Pomagalski Sa Detachable clamp of a vehicle towed by cable.
US5584885A (en) 1994-04-28 1996-12-17 Seckel; Brooke R. Nerve regeneration chamber
US5814404A (en) 1994-06-03 1998-09-29 Minnesota Mining And Manufacturing Company Degradable multilayer melt blown microfibers
DE69531638T2 (en) 1994-06-06 2004-06-17 Osiris Therapeutics, Inc. BIOMATRIX FOR TISSUE REGENATION
US5629077A (en) 1994-06-27 1997-05-13 Advanced Cardiovascular Systems, Inc. Biodegradable mesh and film stent
ES2141953T3 (en) * 1994-08-12 2000-04-01 Minnesota Mining & Mfg COMPOSITIONS OF POLY PRESSURE SENSITIVE ADHESIVES (BETA-HIDROXIORGANOATO).
US5645589A (en) 1994-08-22 1997-07-08 Li Medical Technologies, Inc. Anchor and method for securement into a bore
US5626622A (en) 1994-09-21 1997-05-06 Telectronics Pacing Systems, Inc. Dual sensor rate responsive pacemaker
US5730744A (en) 1994-09-27 1998-03-24 Justin; Daniel F. Soft tissue screw, delivery device, and method
WO1996009797A1 (en) 1994-09-28 1996-04-04 Innovasive Devices, Inc. Suture tensioning device
US5634931A (en) 1994-09-29 1997-06-03 Surgical Sense, Inc. Hernia mesh patches and methods of their use
AU706434B2 (en) 1994-10-18 1999-06-17 Ethicon Inc. Injectable liquid copolymers for soft tissue repair and augmentation
US5599852A (en) 1994-10-18 1997-02-04 Ethicon, Inc. Injectable microdispersions for soft tissue repair and augmentation
US5563239A (en) 1994-11-09 1996-10-08 Eastman Chemical Company Composition and process for the production of poly(3-hydroxyalkanoates)
US5814071A (en) 1994-11-10 1998-09-29 Innovasive Devices, Inc. Suture anchor assembly and methods
US5649963A (en) 1994-11-10 1997-07-22 Innovasive Devices, Inc. Suture anchor assembly and methods
US5643321A (en) 1994-11-10 1997-07-01 Innovasive Devices Suture anchor assembly and methods
US5607686A (en) 1994-11-22 1997-03-04 United States Surgical Corporation Polymeric composition
AU3795395A (en) 1994-11-30 1996-06-06 Ethicon Inc. Hard tissue bone cements and substitutes
US5716358A (en) 1994-12-02 1998-02-10 Johnson & Johnson Professional, Inc. Directional bone fixation device
CA2206099C (en) 1994-12-02 2007-02-06 Omeros Medical Systems, Inc. Tendon and ligament repair system
IL116328A (en) 1994-12-16 1999-09-22 Bracco Research Sa Frozen suspension of gas microbubbles in frozen aqueous carrier for use as contrast agent in ultrasonic imaging
US5824751A (en) * 1995-01-26 1998-10-20 Takasago Koryo Kogyo Kabushiki Kaisha (Takasago International Corporation) Biodegradable high molecular composition
US5665122A (en) 1995-01-31 1997-09-09 Kambin; Parviz Expandable intervertebral cage and surgical method
US5634936A (en) 1995-02-06 1997-06-03 Scimed Life Systems, Inc. Device for closing a septal defect
US5860973A (en) 1995-02-27 1999-01-19 Michelson; Gary Karlin Translateral spinal implant
US5840078A (en) 1995-03-01 1998-11-24 Yerys; Paul Method and apparatus for mechanical attachment of soft tissue to bone tissue
US5580923A (en) 1995-03-14 1996-12-03 Collagen Corporation Anti-adhesion films and compositions for medical use
US5879322A (en) * 1995-03-24 1999-03-09 Alza Corporation Self-contained transdermal drug delivery device
AU704070B2 (en) 1995-04-07 1999-04-15 Linvatec Corporation Package retainer for surgical screw
US5634926A (en) 1995-04-25 1997-06-03 Jobe; Richard P. Surgical bone fixation apparatus
US5639468A (en) 1995-06-07 1997-06-17 University Of Southern California Method for reducing or preventing post-surgical adhesion formation using manoalide and analogs thereof
US5840331A (en) 1995-06-07 1998-11-24 Arch Development Corporation Use of γ-hydroxybutyrate for the stimulation of sleep-related secretion growth hormone and prolactin
US5655546A (en) 1995-06-07 1997-08-12 Halpern; Alan A. Method for cartilage repair
US5702409A (en) 1995-07-21 1997-12-30 W. L. Gore & Associates, Inc. Device and method for reinforcing surgical staples
AU3406495A (en) 1995-08-14 1997-03-12 University Of Massachusetts Medical Center Methods of controlling microbial polyester structure
DE19539449A1 (en) 1995-10-24 1997-04-30 Biotronik Mess & Therapieg Process for the production of intraluminal stents from bioresorbable polymer material
US5736152A (en) 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
US5702715A (en) 1995-10-27 1997-12-30 Drying Technology Reinforced biological sealants
US5827298A (en) 1995-11-17 1998-10-27 Innovasive Devices, Inc. Surgical fastening system and method for using the same
US5843084A (en) 1995-11-17 1998-12-01 Innovasive Devices, Inc. Surgical fastening system and method for using the same
US5725556A (en) 1995-12-15 1998-03-10 M & R Medical, Inc. Suture locking apparatus
US5766253A (en) 1996-01-16 1998-06-16 Surgical Dynamics, Inc. Spinal fusion device
US5842477A (en) 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
US5853422A (en) 1996-03-22 1998-12-29 Scimed Life Systems, Inc. Apparatus and method for closing a septal defect
US5700774A (en) 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
US5670161A (en) 1996-05-28 1997-09-23 Healy; Kevin E. Biodegradable stent
US5791352A (en) 1996-06-19 1998-08-11 Fusion Medical Technologies, Inc. Methods and compositions for inhibiting tissue adhesion
US5807292A (en) 1996-06-24 1998-09-15 Minnesota Mining And Manufacturing Company Orthopedic casting article having soft and hard regions
US5711958A (en) 1996-07-11 1998-01-27 Life Medical Sciences, Inc. Methods for reducing or eliminating post-surgical adhesion formation
US5811272A (en) 1996-07-26 1998-09-22 Massachusetts Institute Of Technology Method for controlling molecular weight of polyhydroxyalkanoates
US5895426A (en) 1996-09-06 1999-04-20 Osteotech, Inc. Fusion implant device and method of use
US5785642A (en) 1996-10-18 1998-07-28 Micro Therapeutics, Inc. Methods for treating urinary incontinence in mammals
US5861003A (en) 1996-10-23 1999-01-19 The Cleveland Clinic Foundation Apparatus and method for occluding a defect or aperture within body surface
JP3369421B2 (en) * 1996-12-18 2003-01-20 理化学研究所 Film composed of poly (3-hydroxybutanoic acid)
ATE297469T1 (en) 1997-03-03 2005-06-15 Metabolix Inc METHOD FOR POLYESTERN BIOSYNTHESIS
EP0973818B1 (en) * 1997-04-03 2004-10-13 Guilford Pharmaceuticals Inc. Biodegradable terephthalate polyester-poly(phosphate) polymers, compositions, articles, and methods for making and using the same
EP0977882B1 (en) * 1997-04-21 2007-06-13 Metabolix, Inc. Hydroxy-terminated polyhydroxyalkanoates
US6610764B1 (en) * 1997-05-12 2003-08-26 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
PT981381E (en) * 1997-05-12 2007-04-30 Metabolix Inc Polyhydroxyalkanoates for in vivo applications
US5910315A (en) 1997-07-18 1999-06-08 Stevenson; Sharon Allograft tissue material for filling spinal fusion cages or related surgical spaces
US5876455A (en) 1997-07-24 1999-03-02 Harwin; Steven F. Bio-shim
EP1042388B1 (en) * 1997-12-22 2006-11-15 Metabolix, Inc. Polyhydroxyalkanoate compositions having controlled degradation rates
JP3723683B2 (en) * 1998-03-25 2005-12-07 ユニチカ株式会社 Biodegradable molded product
US6056970A (en) * 1998-05-07 2000-05-02 Genzyme Corporation Compositions comprising hemostatic compounds and bioabsorbable polymers
US7662409B2 (en) * 1998-09-25 2010-02-16 Gel-Del Technologies, Inc. Protein matrix materials, devices and methods of making and using thereof
FR2784580B1 (en) * 1998-10-16 2004-06-25 Biosepra Inc POLYVINYL-ALCOHOL MICROSPHERES AND METHODS OF MAKING THE SAME
CA2363262C (en) * 1999-03-04 2010-09-28 Tepha, Inc. Bioabsorbable, biocompatible polymers for tissue engineering
WO2000056376A1 (en) * 1999-03-25 2000-09-28 Metabolix, Inc. Medical devices and applications of polyhydroxyalkanoate polymers
US7025980B1 (en) * 1999-09-14 2006-04-11 Tepha, Inc. Polyhydroxyalkanoate compositions for soft tissue repair, augmentation, and viscosupplementation
US20020168518A1 (en) * 2001-05-10 2002-11-14 The Procter & Gamble Company Fibers comprising starch and polymers
US6770356B2 (en) * 2001-08-07 2004-08-03 The Procter & Gamble Company Fibers and webs capable of high speed solid state deformation
US7722894B2 (en) * 2001-10-22 2010-05-25 Massachusetts Institute Of Technology Biodegradable polymer
WO2003066733A1 (en) * 2002-02-05 2003-08-14 Mitsui Chemicals, Inc. Biodegradable resin composition and molded object thereof
US6838492B2 (en) * 2002-06-17 2005-01-04 Scentco, Llc. Scented paints, paint scenting additive mixtures and processes for producing scented paints
PT1778305E (en) * 2004-08-03 2010-07-27 Tepha Inc Non-curling polyhydroxyalkanoate sutures
US9042202B2 (en) 2009-06-10 2015-05-26 Optoplan As Split-element optical hydrophone

Also Published As

Publication number Publication date
US6548569B1 (en) 2003-04-15
EP1163019A1 (en) 2001-12-19
ATE376433T1 (en) 2007-11-15
AU778081B2 (en) 2004-11-11
DE60036863T2 (en) 2008-07-31
US20050107578A1 (en) 2005-05-19
DE60036863D1 (en) 2007-12-06
ES2295021T3 (en) 2008-04-16
PT1163019E (en) 2007-12-06
JP2002539854A (en) 2002-11-26
EP1867348A3 (en) 2008-01-09
EP2305324B1 (en) 2014-09-17
WO2000056376A1 (en) 2000-09-28
ES2395057T3 (en) 2013-02-07
US20020173558A1 (en) 2002-11-21
JP5031144B2 (en) 2012-09-19
ES2525553T3 (en) 2014-12-26
CY1107044T1 (en) 2012-09-26
US7553923B2 (en) 2009-06-30
EP1867348B1 (en) 2012-05-16
US20080051490A1 (en) 2008-02-28
US20020156150A1 (en) 2002-10-24
EP2305324A1 (en) 2011-04-06
EP1163019B1 (en) 2007-10-24
US7179883B2 (en) 2007-02-20
WO2000056376A9 (en) 2002-07-11
EP1867348A2 (en) 2007-12-19
US7268205B2 (en) 2007-09-11
US20080095823A1 (en) 2008-04-24
US6838493B2 (en) 2005-01-04
AU4027700A (en) 2000-10-09
US6867247B2 (en) 2005-03-15
US20070135929A1 (en) 2007-06-14
CA2368470C (en) 2011-05-17
DK1163019T3 (en) 2008-03-03

Similar Documents

Publication Publication Date Title
CA2368470A1 (en) Medical devices and applications of polyhydroxyalkanoate polymers
US6441073B1 (en) Biological materials
EP2598180B1 (en) Hyaluronic acid based hydrogel and use thereof in surgery
JP3483753B2 (en) Biodegradable absorbent plastic adhesive
KR101005079B1 (en) Biodegradable Nanofiber sheet for Anti-adhesion Membrane and Process for Preparing the Same
EP2181722B1 (en) Delayed gelation compositions and methods of use
EP0226061B1 (en) High molecular weight bioresorbable polymers and implantation devices thereof
US7901705B2 (en) Antimicrobial releasing polymers
US5688900A (en) Absorbable polyalkylene diglycolates
JPH0859811A (en) Biocompatible block copolymer
US8575301B2 (en) Absorbable polymer formulations
KR100464930B1 (en) Barrier membrance for guided tissue regeneration and the preparation thereof
CN109851744B (en) Degradable polyurethane biomaterial and preparation method and application thereof
KR20190012958A (en) Medicinal suture yarn coated with polydeoxyribonucleotide and method of manufacturing the same
CN114395164B (en) Polysaccharide composite gel and preparation method and application thereof
CN112999430A (en) Oral cavity repairing film and preparation method thereof
KR20170075723A (en) Composition containing glycosaminoglycans and proteins
CA2682291C (en) Device made at least partially of n-acetylchitosan with controlled biodissolution
Wray et al. Biomaterials for Scaffolds: Natural Polymers’
Aydın et al. Bioresorbable polymers for medical applications
US20220362438A1 (en) Derivatized or Rapidly Polymerizing Collagen Compositions for Tissue Augmentation Containing Nonresorbable or Slowly Resorbable Polymers
CN109970957B (en) Controllable biodegradable copolymer with alkaline copolymerization center
Vidovic The development of bioabsorbable hydrogels on the basis of polyester grafted poly (vinyl alcohol)

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20200324