CA2385150A1 - Vascular coating composition - Google Patents
Vascular coating composition Download PDFInfo
- Publication number
- CA2385150A1 CA2385150A1 CA002385150A CA2385150A CA2385150A1 CA 2385150 A1 CA2385150 A1 CA 2385150A1 CA 002385150 A CA002385150 A CA 002385150A CA 2385150 A CA2385150 A CA 2385150A CA 2385150 A1 CA2385150 A1 CA 2385150A1
- Authority
- CA
- Canada
- Prior art keywords
- weight
- proteinaceous material
- composition
- coating
- polyaldehyde
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3625—Vascular tissue, e.g. heart valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/92—Method or apparatus for preparing or treating prosthetic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/92—Method or apparatus for preparing or treating prosthetic
- Y10S623/921—Blood vessel
Abstract
This invention relates to methods of coating the lumenal surface of a blood vessel, or other tissue cavity, and to compositions suitable for use in same.
Claims (16)
1. A method of treating an endoluminal surface of a tissue comprising coating said surface with a first composition comprising about 27-53% by weight of a water soluble proteinaceous material and with a second composition comprising about 5-15% by weight of a di- or polyaldehyde, wherein said di- or polyaldehyde is present in said coating in a weight ratio of one part by weight to every 20-60 parts by weight of said proteinaceous material, and allowing said composition to cure.
2. The method according to claim 1 wherein said proteinaceous material a globular protein.
3. The method according to claim 1 wherein said proteinaceous material is albumin or hemoglobin.
4. The method according to claim 3 wherein said proteinaceous material is bovine albumin.
5. The method according to claim 1 wherein said aldehyde is glutaraldehyde.
6. The method according to claim 1 wherein said proteinaceous material is bovine albumin and said aldehyde is glutaraldehyde.
7. The method according to claim 1 wherein said composition further comprises a therapeutic agent.
8. The method according to claim 7 wherein said therapeutic agent is selected from the group consisting of an anti-thrombotic agent, a thrombolytic agent, a vasodilating agent, a growth modulating factor and an antibiotic.
9. The method according to claim 1 wherein said surface is the surface of an artery.
10. The method according to claim 1 wherein said surface is the surface of a vascular or dialysis graft.
11. The method according to claim 1 wherein said surface is selected from the group consisting of the surface of a vein, ureter, urethrae, bronchi, biliary duct, pancreatic duct, gut, eye, nasal passage, sinus, capsular joint, esophagus, lymphatic system, trachea, spermatic tube and fallopian tube.
12. The method according to claim 1 wherein said surface is a surgically or traumatically formed lumen in a naturally solid organ or tissue.
13. The method according to claim 1 wherein said surface is a surface of a native or disease generated lumen of a hollow or tubular organ.
14. The method according to claim 1 wherein said surface is a site of anastomosis.
15. A method of inhibiting restenosis following vascular intervention comprising coating a site of vascular injury resulting from said intervention with a first composition comprising about 27-53% by weight of a water soluble proteinaceous material and with a second composition comprising about 5-15% by weight of a di- or polyaldehyde, wherein said di- or polyaldehyde is present in said coating in a weight ratio of one part by weight to every 20-60 parts by weight of said proteinaceous material, and allowing said composition to cure.
16. The method according to claim 15 wherein said intervention is angioplasty.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15395099P | 1999-09-15 | 1999-09-15 | |
US60/153,950 | 1999-09-15 | ||
PCT/US2000/025310 WO2001019347A1 (en) | 1999-09-15 | 2000-09-15 | Vascular coating composition |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2385150A1 true CA2385150A1 (en) | 2001-03-22 |
CA2385150C CA2385150C (en) | 2010-11-23 |
Family
ID=22549391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2385150A Expired - Fee Related CA2385150C (en) | 1999-09-15 | 2000-09-15 | Vascular coating composition |
Country Status (10)
Country | Link |
---|---|
US (2) | US6372229B1 (en) |
EP (1) | EP1214057B1 (en) |
JP (1) | JP2003509362A (en) |
AT (1) | ATE446776T1 (en) |
AU (1) | AU769136B2 (en) |
CA (1) | CA2385150C (en) |
DE (1) | DE60043229D1 (en) |
HK (1) | HK1047404B (en) |
NO (1) | NO20021281L (en) |
WO (1) | WO2001019347A1 (en) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001019347A1 (en) * | 1999-09-15 | 2001-03-22 | Cryolife, Inc. | Vascular coating composition |
US20040018228A1 (en) * | 2000-11-06 | 2004-01-29 | Afmedica, Inc. | Compositions and methods for reducing scar tissue formation |
CA2494295C (en) | 2002-08-06 | 2012-05-01 | Matrix Medical, Llc | Biocompatible phase invertable proteinaceous compositions and methods for making and using the same |
US10098981B2 (en) | 2002-08-06 | 2018-10-16 | Baxter International Inc. | Biocompatible phase invertable proteinaceous compositions and methods for making and using the same |
US8349348B2 (en) * | 2002-08-06 | 2013-01-08 | Matrix Medical, Llc | Biocompatible phase invertible proteinaceous compositions and methods for making and using the same |
US9101536B2 (en) * | 2002-08-06 | 2015-08-11 | Matrix Medical Llc | Biocompatible phase invertable proteinaceous compositions and methods for making and using the same |
DE10236152A1 (en) * | 2002-08-07 | 2004-02-19 | Marker Deutschland Gmbh | Ski and ski binding combination |
US7803150B2 (en) * | 2004-04-21 | 2010-09-28 | Acclarent, Inc. | Devices, systems and methods useable for treating sinusitis |
US7670282B2 (en) | 2004-06-14 | 2010-03-02 | Pneumrx, Inc. | Lung access device |
US20060004400A1 (en) * | 2004-06-16 | 2006-01-05 | Mcgurk Erin | Method of treating a lung |
US20050281739A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Imaging damaged lung tissue using compositions |
US20050281740A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Imaging damaged lung tissue |
US7678767B2 (en) | 2004-06-16 | 2010-03-16 | Pneumrx, Inc. | Glue compositions for lung volume reduction |
US7608579B2 (en) * | 2004-06-16 | 2009-10-27 | Pneumrx, Inc. | Lung volume reduction using glue compositions |
US7553810B2 (en) * | 2004-06-16 | 2009-06-30 | Pneumrx, Inc. | Lung volume reduction using glue composition |
US20050281799A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Targeting damaged lung tissue using compositions |
US20050281798A1 (en) * | 2004-06-16 | 2005-12-22 | Glen Gong | Targeting sites of damaged lung tissue using composition |
WO2006014567A2 (en) * | 2004-07-08 | 2006-02-09 | Pneumrx, Inc. | Pleural effusion treatment device, method and material |
US7766891B2 (en) | 2004-07-08 | 2010-08-03 | Pneumrx, Inc. | Lung device with sealing features |
EP1816945B1 (en) | 2004-11-23 | 2019-08-21 | PneumRx, Inc. | Steerable device for accessing a target site |
US20070014830A1 (en) * | 2005-06-08 | 2007-01-18 | Tijsma Edze J | Drug-releasing sinus stent |
US20070110788A1 (en) * | 2005-11-14 | 2007-05-17 | Hissong James B | Injectable formulation capable of forming a drug-releasing device |
US8888800B2 (en) | 2006-03-13 | 2014-11-18 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US9402633B2 (en) | 2006-03-13 | 2016-08-02 | Pneumrx, Inc. | Torque alleviating intra-airway lung volume reduction compressive implant structures |
US8157837B2 (en) | 2006-03-13 | 2012-04-17 | Pneumrx, Inc. | Minimally invasive lung volume reduction device and method |
US7976873B2 (en) * | 2006-05-10 | 2011-07-12 | Medtronic Xomed, Inc. | Extracellular polysaccharide solvating system for treatment of bacterial ear conditions |
US7959943B2 (en) * | 2006-05-10 | 2011-06-14 | Medtronics Xomed, Inc. | Solvating system and sealant for medical use in the middle or inner ear |
US7993675B2 (en) * | 2006-05-10 | 2011-08-09 | Medtronic Xomed, Inc. | Solvating system and sealant for medical use in the sinuses and nasal passages |
AU2007294808A1 (en) * | 2006-09-13 | 2008-03-20 | Southeastern Medical Technologies, Llc | Methods and compositions for sealing and adhering biological tissues and medical uses thereof |
US20100297218A1 (en) * | 2006-09-20 | 2010-11-25 | Pneumrx, Inc. | Tissue adhesive compositions and methods thereof |
US8088095B2 (en) * | 2007-02-08 | 2012-01-03 | Medtronic Xomed, Inc. | Polymeric sealant for medical use |
US20090011043A1 (en) * | 2007-07-03 | 2009-01-08 | Hua Xie | Tissue sealant made from whole blood |
EP2219555B9 (en) | 2007-12-03 | 2015-12-23 | Tenaxis Medical, Inc. | Biocompatible phase invertible proteinaceous compositions |
CA2727432C (en) | 2008-06-12 | 2016-10-11 | Medtronic Xomed, Inc. | Method for treating chronic wounds with an extracellular polymeric substance solvating system |
US9173669B2 (en) | 2008-09-12 | 2015-11-03 | Pneumrx, Inc. | Enhanced efficacy lung volume reduction devices, methods, and systems |
US9155815B2 (en) * | 2009-04-17 | 2015-10-13 | Tenaxis Medical, Inc. | Biocompatible phase invertible proteinaceous compositions and methods for making and using the same |
CN104622599B (en) | 2009-05-18 | 2017-04-12 | 纽姆克斯股份有限公司 | Cross-sectional modification during deployment of an elongate lung volume reduction device |
US20110077216A1 (en) * | 2009-09-30 | 2011-03-31 | Massachusetts Institute Of Technology | Compositions and methods for the treatment of atherosclerosis and other related diseases |
US10390838B1 (en) | 2014-08-20 | 2019-08-27 | Pneumrx, Inc. | Tuned strength chronic obstructive pulmonary disease treatment |
WO2019231763A1 (en) | 2018-05-27 | 2019-12-05 | Christos Angeletakis | Tissue adhesives and sealants using naturally derived aldehydes |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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US4247406A (en) * | 1979-04-23 | 1981-01-27 | Widder Kenneth J | Intravascularly-administrable, magnetically-localizable biodegradable carrier |
US4979959A (en) | 1986-10-17 | 1990-12-25 | Bio-Metric Systems, Inc. | Biocompatible coating for solid surfaces |
US5213580A (en) * | 1988-08-24 | 1993-05-25 | Endoluminal Therapeutics, Inc. | Biodegradable polymeric endoluminal sealing process |
US5843156A (en) * | 1988-08-24 | 1998-12-01 | Endoluminal Therapeutics, Inc. | Local polymeric gel cellular therapy |
JP2836878B2 (en) * | 1988-08-24 | 1998-12-14 | スリピアン,マービン,ジェイ | Intraluminal sealing with biodegradable polymer material |
US5654267A (en) | 1988-12-20 | 1997-08-05 | La Jolla Cancer Research Center | Cooperative combinations of ligands contained within a matrix |
CA2070149A1 (en) * | 1991-06-04 | 1992-12-05 | Stephen J. Boccuzzi | Hmg-coa reductase inhibitors in the prevention of restenosis following coronary angloplasty |
US5385606A (en) * | 1992-07-06 | 1995-01-31 | Kowanko; Nicholas | Adhesive composition and method |
US5914345A (en) * | 1994-10-11 | 1999-06-22 | Endoluminal Therapeutics, Inc. | Treatment of tissues to reduce subsequent response to injury |
US5900245A (en) * | 1996-03-22 | 1999-05-04 | Focal, Inc. | Compliant tissue sealants |
WO2001019347A1 (en) * | 1999-09-15 | 2001-03-22 | Cryolife, Inc. | Vascular coating composition |
-
2000
- 2000-09-15 WO PCT/US2000/025310 patent/WO2001019347A1/en active IP Right Grant
- 2000-09-15 DE DE60043229T patent/DE60043229D1/en not_active Expired - Lifetime
- 2000-09-15 AU AU73811/00A patent/AU769136B2/en not_active Ceased
- 2000-09-15 AT AT00961923T patent/ATE446776T1/en not_active IP Right Cessation
- 2000-09-15 US US09/662,459 patent/US6372229B1/en not_active Expired - Lifetime
- 2000-09-15 CA CA2385150A patent/CA2385150C/en not_active Expired - Fee Related
- 2000-09-15 JP JP2001522982A patent/JP2003509362A/en active Pending
- 2000-09-15 EP EP00961923A patent/EP1214057B1/en not_active Expired - Lifetime
-
2002
- 2002-02-07 US US10/067,331 patent/US6849262B2/en not_active Expired - Fee Related
- 2002-03-14 NO NO20021281A patent/NO20021281L/en not_active Application Discontinuation
- 2002-12-12 HK HK02109028.5A patent/HK1047404B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1214057A1 (en) | 2002-06-19 |
NO20021281L (en) | 2002-03-26 |
US6849262B2 (en) | 2005-02-01 |
WO2001019347A1 (en) | 2001-03-22 |
JP2003509362A (en) | 2003-03-11 |
ATE446776T1 (en) | 2009-11-15 |
US20020183244A1 (en) | 2002-12-05 |
EP1214057B1 (en) | 2009-10-28 |
EP1214057A4 (en) | 2006-03-29 |
CA2385150C (en) | 2010-11-23 |
HK1047404B (en) | 2010-05-20 |
AU7381100A (en) | 2001-04-17 |
NO20021281D0 (en) | 2002-03-14 |
DE60043229D1 (en) | 2009-12-10 |
US6372229B1 (en) | 2002-04-16 |
HK1047404A1 (en) | 2003-02-21 |
AU769136B2 (en) | 2004-01-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |