CA2387728C - Test element analysis system with an infrared detector - Google Patents
Test element analysis system with an infrared detector Download PDFInfo
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- CA2387728C CA2387728C CA002387728A CA2387728A CA2387728C CA 2387728 C CA2387728 C CA 2387728C CA 002387728 A CA002387728 A CA 002387728A CA 2387728 A CA2387728 A CA 2387728A CA 2387728 C CA2387728 C CA 2387728C
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- analysis system
- test element
- test
- infrared radiation
- measurement
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/8483—Investigating reagent band
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48785—Electrical and electronic details of measuring devices for physical analysis of liquid biological material not specific to a particular test method, e.g. user interface or power supply
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/121—Correction signals
- G01N2201/1211—Correction signals for temperature
Abstract
Test element analysis system (1) for the analytical investigation of a sample (8), in particular of a body liquid, of human beings or of animals, comprising test elements (3) with a test zone (7), to be brought in contact with the sample to be investigated for the purpose of performing an analysis, in order to measure a measurement quantity characteristic for the analysis, and an evaluation instrument (2) with a test element holder (5) for positioning a test element (3) in a measuring position in order to perform a measurement, and a measurement and evaluation electronics (15) for measuring the characteristic change and for determining a result of the analysis, based on the result of the measurement. In order to provide increased measuring accuracy by improved temperature compensation, it is proposed, in the scope of the invention, that the evaluation instrument (2) for the determination of the temperature prevailing in the test zone (7) of the test element (3) comprises an infrared detector (20).
Description
Test Element Analysis System With An Infrared Detector The invention relates to a test element analysis system for the analytical investigation of a sample, in particular a body liquid, of human beings or of animals.
The system consists of two components, namely test elements, comprising a test zone to which the sample to be investigated is contacted in order to perform an analysis by measuring a measurement quantity charac-teristic for the analysis, and an evaluation instrument with a test element holder for positioning a test element in a measuring position for making the measurement, and with a measuring and evaluation electronics for measuring the characteristic measurement quantity and deriving an analytical result therefrom-.
Test element analysis systems are common in medical science, in particular for the analysis of blood and urine. In most cases, the test elements have the form of test strips. Other forms of test elements are, however, also common, e.g. flat, almost square plates.
^
The system consists of two components, namely test elements, comprising a test zone to which the sample to be investigated is contacted in order to perform an analysis by measuring a measurement quantity charac-teristic for the analysis, and an evaluation instrument with a test element holder for positioning a test element in a measuring position for making the measurement, and with a measuring and evaluation electronics for measuring the characteristic measurement quantity and deriving an analytical result therefrom-.
Test element analysis systems are common in medical science, in particular for the analysis of blood and urine. In most cases, the test elements have the form of test strips. Other forms of test elements are, however, also common, e.g. flat, almost square plates.
^
Generally, the test elements contain reagents the reaction of which with the sample leads to a physically detectable change of the test element. This change is measured with the evaluation instrument belonging to the system. In particular, photometrical analysis systems are common, using test elements in which the reaction causes a color change of a detection layer which is measured photometrically. Furthermore, electrochemical analysis systems are of important significance. Here an electrically measurable change of the test element, in form of a voltage or a current, occurs due to the reaction. In addition to these analysis systems working with reagents, reagent-free analysis systems are also discussed, in which an analytically characteristic property (e.g. the light absorption spectrum) of the sample itself is measured after bringing the test element in contact with the sample. The invention is generally applicable to all these methods.
Test element analysis systems are to some extent used in medical laboratories. The invention is, however, particularly intended for application cases in which the patients themselves perform the analysis in order to monitor his or her health state (home monitoring). This is of particular medical importance for diabetics, who have to check their blood glucose concentration several times a day in order to adjust the insulin injections accordingly. For such purposes, the evaluation instruments must be light-weight, small, battery-operated and robust.
A fundamental problem is caused by the fact that the measured quantity which is characteristic for the analysis, is often very temperature-dependent. This temperature dependence is, in many cases, about one or two percent per degree. In the area of home-monitoring, the exposure of the analysis system to large temperature changes is unavoidable. Temperature variations of at least 5% have to be taken into account. Much higher temperature variations may occur, however, e.g. if measurements under unusual conditions (in the car or outdoors) are required.
In order to avoid the measurement uncertainties resulting therefrom, it was proposed to temper the test zone of the test element by means of a corresponding thermostating device, in order to provide a defined, constant temperature. For example, US patent 5,035,862 describes the tempering of individual test fields of urine test strips by means of inductive heating. Another example, for a blood analysis instrument, is described in DE
3321783 Al. Such methods are, however, due to their high energy consumption, not practicable for small battery-operated instruments.
In some analysis systems, the temperature is determined electrically (by means of a thermocouple or a thermal resistor) at the time of the measurement in the housing of the evaluation instrument, and the measured temperature is taken into account for the determination of the analysis result. An example is described in WO
99/06822. Such a correction can be exact if the temperature in the environment of the evaluation instrument and the test element did not change significantly for an extended period before the measure-ment, so that the actual temperature of the sample in the measuring position almost equals to the electrically measured temperature. In particular in the field of home-monitoring, however, this condition is not always given, as the life circumstances of the patient require analyses to be performed at different places and with changing temperature conditions.
^
Test element analysis systems are to some extent used in medical laboratories. The invention is, however, particularly intended for application cases in which the patients themselves perform the analysis in order to monitor his or her health state (home monitoring). This is of particular medical importance for diabetics, who have to check their blood glucose concentration several times a day in order to adjust the insulin injections accordingly. For such purposes, the evaluation instruments must be light-weight, small, battery-operated and robust.
A fundamental problem is caused by the fact that the measured quantity which is characteristic for the analysis, is often very temperature-dependent. This temperature dependence is, in many cases, about one or two percent per degree. In the area of home-monitoring, the exposure of the analysis system to large temperature changes is unavoidable. Temperature variations of at least 5% have to be taken into account. Much higher temperature variations may occur, however, e.g. if measurements under unusual conditions (in the car or outdoors) are required.
In order to avoid the measurement uncertainties resulting therefrom, it was proposed to temper the test zone of the test element by means of a corresponding thermostating device, in order to provide a defined, constant temperature. For example, US patent 5,035,862 describes the tempering of individual test fields of urine test strips by means of inductive heating. Another example, for a blood analysis instrument, is described in DE
3321783 Al. Such methods are, however, due to their high energy consumption, not practicable for small battery-operated instruments.
In some analysis systems, the temperature is determined electrically (by means of a thermocouple or a thermal resistor) at the time of the measurement in the housing of the evaluation instrument, and the measured temperature is taken into account for the determination of the analysis result. An example is described in WO
99/06822. Such a correction can be exact if the temperature in the environment of the evaluation instrument and the test element did not change significantly for an extended period before the measure-ment, so that the actual temperature of the sample in the measuring position almost equals to the electrically measured temperature. In particular in the field of home-monitoring, however, this condition is not always given, as the life circumstances of the patient require analyses to be performed at different places and with changing temperature conditions.
^
In order to solve this problem, US patent 5,405,511 proposes to measure the temperature repeatedly in regular intervals, and to determine the corrective temperature by extrapolation based on the temperature history measured over a certain period of time. This, however, requires a permanent determination of the temperature, continuously or in certain intervals, over a period of several minutes before the analysis. In order to avoid the resulting waiting time before the test, temperature measurements are, according to US patent 5,405,511, also performed when the instrument is switched off in intervals of several minutes. This allows to make the extrapolation to the corrective temperature immediately after the instru-ment is switched on. This method, however, causes an increased battery consumption, as the electronic system of the instrument must be put into operation in intervals of several minutes, in order to determine the tempe-rature. Furthermore, the estimation of the corrective temperature by means of an extrapolation algorithm is not reliable under all operating conditions.
EP 0851229 Al describes an analysis system in which a temperature measuring surface coated with a thermo-chromous liquid crystal (TLC) is located at the holder of the test element or at the test element itself. The temperature of the TLC is determined by photometrical measurement. Here, good correspondence of the measurement with the actual temperature of the test zone can only be achieved if the test element itself is coated with the TLC. This, however, leads to considerable additional cost for the production of the test elements. Furthermore, an acceptable accuracy of the temperature measurement can only be achieved with high expense for the measurement technology.
The invention addresses the problem to provide a test element analysis system which provides an increased measurement accuracy by an improved temperature compensation. This should be achieved with low expense, 5 as appropriate for home-monitoring systems.
In a test element analysis system of the previously described type the problem is solved by providing the evaluation instrument with an infrared detector for the determination of the temperature in the test zone of the test element.
The particular requirements of common test strip analysis systems have the disadvantage that in most cases it is not possible to position an infrared detector in such a manner that it directly detects the infrared radiation coming from the test zone with sufficient selectivity and sensitivity in order to ensure the required exactness of the temperature measurement. According to a preferred embodiment of the invention this problem is solved by providing a connection of the test zone and the infrared detector by a location-selective infrared radiation transport device fulfilling the following requirements:
- It selectively transmits the IR radiation emerging from the test zone to the detector.
- A very high share of the IR radiation emerging from the test zone arrives at the detector, i.e. the transport device works almost loss-free.
Principally, these requirements can be fulfilled with an optical imaging system which comprises at least one lens.
Substantially preferred components of the infrared transport device are, however, a hollow conductor with IR-reflecting interior walls, in particular made of metal-coated plastics, and/or an imaging mirror located inside the housing. These elements allow an almost loss-free IR transport from the test zone to the infrared detector, as well as a very good selectivity. The cost is low, and it is possible, without any problems, to provide a curved or polygonal (non-straight) radiation path between the test zone and the infrared detector. This allows a realization of the infrared temperature measurement of the test zone, which is optimally adapted to the requirements of a test element analysis system.
The invention is hereafter described in more detail with reference to exemplary embodiments shown in the figures.
The described features can be used single or in combination in order to create preferred embodiments of this invention.
Fig. 1 shows a test element analysis system according to the invention, Fig. 2 shows a partial sectional view of an analysis system according to the invention, Fig. 3 shows a partial sectional view of an alternative embodiment, Fig. 4 shows a diagrammatic sectional view of a further alternative embodiment, Fig. 5 shows a diagrammatic sectional view of a third alternative embodiment.
The analysis system shown in figures 1 and 2 consists of an evaluation instrument 2 and of disposable test elements 3 for single use.
^
EP 0851229 Al describes an analysis system in which a temperature measuring surface coated with a thermo-chromous liquid crystal (TLC) is located at the holder of the test element or at the test element itself. The temperature of the TLC is determined by photometrical measurement. Here, good correspondence of the measurement with the actual temperature of the test zone can only be achieved if the test element itself is coated with the TLC. This, however, leads to considerable additional cost for the production of the test elements. Furthermore, an acceptable accuracy of the temperature measurement can only be achieved with high expense for the measurement technology.
The invention addresses the problem to provide a test element analysis system which provides an increased measurement accuracy by an improved temperature compensation. This should be achieved with low expense, 5 as appropriate for home-monitoring systems.
In a test element analysis system of the previously described type the problem is solved by providing the evaluation instrument with an infrared detector for the determination of the temperature in the test zone of the test element.
The particular requirements of common test strip analysis systems have the disadvantage that in most cases it is not possible to position an infrared detector in such a manner that it directly detects the infrared radiation coming from the test zone with sufficient selectivity and sensitivity in order to ensure the required exactness of the temperature measurement. According to a preferred embodiment of the invention this problem is solved by providing a connection of the test zone and the infrared detector by a location-selective infrared radiation transport device fulfilling the following requirements:
- It selectively transmits the IR radiation emerging from the test zone to the detector.
- A very high share of the IR radiation emerging from the test zone arrives at the detector, i.e. the transport device works almost loss-free.
Principally, these requirements can be fulfilled with an optical imaging system which comprises at least one lens.
Substantially preferred components of the infrared transport device are, however, a hollow conductor with IR-reflecting interior walls, in particular made of metal-coated plastics, and/or an imaging mirror located inside the housing. These elements allow an almost loss-free IR transport from the test zone to the infrared detector, as well as a very good selectivity. The cost is low, and it is possible, without any problems, to provide a curved or polygonal (non-straight) radiation path between the test zone and the infrared detector. This allows a realization of the infrared temperature measurement of the test zone, which is optimally adapted to the requirements of a test element analysis system.
The invention is hereafter described in more detail with reference to exemplary embodiments shown in the figures.
The described features can be used single or in combination in order to create preferred embodiments of this invention.
Fig. 1 shows a test element analysis system according to the invention, Fig. 2 shows a partial sectional view of an analysis system according to the invention, Fig. 3 shows a partial sectional view of an alternative embodiment, Fig. 4 shows a diagrammatic sectional view of a further alternative embodiment, Fig. 5 shows a diagrammatic sectional view of a third alternative embodiment.
The analysis system shown in figures 1 and 2 consists of an evaluation instrument 2 and of disposable test elements 3 for single use.
^
The evaluation instrument 2 has a test element holder 5 for fixing a test element 3 in the measuring position shown in figure 2. The test element 3 is fixed in the measuring position by appropriate means, as e.g. a leaf spring 6.
For making a measurement, the sample liquid (e.g. blood) has to be contacted to a measurement zone 7. In the shown embodiment of a test element this is achieved by applying a blood drop 8 to a sample application zone 9 located at the end of the test element 3 from where it is suctioned to the measurement zone 7 through a capillary gap 10. A
reagent layer 12, to be dissolved by the sample liquid and reacting with its components, is located in the measurement zone 7.
The reaction leads to a measurable change in the measurement zone 7. In the shown case of an electrochemical test element, the measurement of an electrical measurement quantity is performed by means of electrodes located in the measurement zone (not shown in the figure) connected to contact stripes 13. In the measuring position, the contact stripes 13 establish an electrical contact to corresponding countercontacts 14 of the test element holder 5 which again are connected to a measuring and evaluation electronics 15. The measuring and evaluation electronics 15 is highly integrated for compact design and high reliability. In the shown case, it essentially consists of a printed circuit board 16 and a special IC (ASIC) 17.
An infrared detector 20 for the determination of the temperature in the test zone 7 is also mounted on the printed circuit board 16. Appropriate infrared detectors are inexpensively available. Preferably, a detector type ^
For making a measurement, the sample liquid (e.g. blood) has to be contacted to a measurement zone 7. In the shown embodiment of a test element this is achieved by applying a blood drop 8 to a sample application zone 9 located at the end of the test element 3 from where it is suctioned to the measurement zone 7 through a capillary gap 10. A
reagent layer 12, to be dissolved by the sample liquid and reacting with its components, is located in the measurement zone 7.
The reaction leads to a measurable change in the measurement zone 7. In the shown case of an electrochemical test element, the measurement of an electrical measurement quantity is performed by means of electrodes located in the measurement zone (not shown in the figure) connected to contact stripes 13. In the measuring position, the contact stripes 13 establish an electrical contact to corresponding countercontacts 14 of the test element holder 5 which again are connected to a measuring and evaluation electronics 15. The measuring and evaluation electronics 15 is highly integrated for compact design and high reliability. In the shown case, it essentially consists of a printed circuit board 16 and a special IC (ASIC) 17.
An infrared detector 20 for the determination of the temperature in the test zone 7 is also mounted on the printed circuit board 16. Appropriate infrared detectors are inexpensively available. Preferably, a detector type ^
including an integrated temperature sensor for self-calibration (e.g. a NTC semiconductor element) is chosen.
Generally it is advantageous if the infrared detector 20 is integrated into the measuring and evaluation electronics 15 in such a manner that a rigid mechanic connection is provided between the infrared detector 20 and the further components of the measuring and evaluation electronics 15. Short and mechanically rigid conductor connections between the infrared detector 20 and the further components of the measuring and evaluation electronics 15 do not only allow a compact design, but also provide high mechanic and electrical stability as well as a good long-term reliability.
At first glance it seems disadvantageous that the transmission path shown in dotted line in figure 2 which the IR radiation must travel from the test zone 7 to the infrared detector 20 is relatively long and not straight.
This is particularly true if the evaluation instrument has a very flat design which is desirable (for easy handling) in practical use, but does not allow to arrange the test element holder 5 above the electronic unit 15.
Additional problems arise if the test element and the holder of the evaluation instrument are formed - as shown - in such a manner that the test element 3, when in the measuring position, sticks out of the housing 23 of the evaluation instrument 2. Such a design is advantageous for the handling of the analysis system, since the sample can be provided to the test zone 7 while the test element is already in the measuring position. However, for the determination of the temperature in the test zone 7, this implies the disadvantage that the transmission path 21 must pass through a window 26 arranged in the housing 2 and including a section 21a located outside the housing 23.
The infrared transport device, designated as 22, enables even in such difficult cases a selective and sensitive detection of the infrared radiation coming from the test zone 7. In the shown case, it consists of a hollow conductor 24 with IR-reflecting interior walls, and an imaging mirror 25 located inside the housing 23 of the evaluation instrument 2.
The hollow conductor 24 is made from a plastic part which is at least in its interior metal-coated (in particular, gold-plated). By means of this hollow conductor 24, the desired IR transmission path 21 can be realized within the housing 25, in a simple and inexpensive way.
If - as in case of the shown test element analysis system - the IR transmission path 21 includes a section 21a located outside the housing 25 of the evaluation instrument 2, it is advantageous to realize in this section the necessary selective detection of the IR
radiation coming from the test zone 7 by means of an optical imaging system. Preferably a concave imaging mirror 25 as shown in figure 2 is used. The optical window 26 is closed dust-proof, preferably with a pane 28 transparent for infrared radiation, in particular a polyethylene sheet.
Figure 3 shows an alternative embodiment in which the optical imaging system is formed by an optical lens integrated into the pane 28, whereas the required beam deflection of the IR radiation on the transmission path 21 is provided by a plane mirror 29.
In the embodiments shown in figures 2 and 3, the function of the location-selective light transport device 22 is essentially based on the effect of an optical imaging system realized by the imaging mirror 25 or the lens 27.
Inside hollow conductor 24 the light path is mainly influenced by the rear, inclined surface which acts as a 5 plane mirror 30 and essentially effects the required deflection to the IR detector 20.
A very effective and at the same time very inexpensive realization of the location-selective IR transport device can be provided (even without an optical imaging system) 10 by means of a hollow conductor with mirror-coated interior, which is designed in such a manner - as shown in figures 4 and 5 - that the input opening 31 facing the test zone 7 has a larger opening cross-section than the output opening 32 facing the infrared detector. In such an embodiment it is advantageous if the hollow conductor 24 tapers continuously between the input opening 31 and the output opening 32, i.e. its cross-section decreases gradually along the path. In this way a concentration of the infrared radiation intensity reflected at the interior walls of the hollow conductor 24 is provided.
In the embodiment shown in figure 4, the axis of hollow conductor 24 is a straight line. In this case, the light-sensitive surface of the detector 20 is located in a lateral position. However, it is easily possible to produce the hollow conductor 24 in a curved embodiment, as shown in figure 5. Such a curved embodiment enables a particularly flexible design and positioning of the test element 3 with the test zone 7 and of the printed circuit board 16 with the detector 20.
Although figures 4 and 5 do not show an optical imaging system, it is of course possible to combine a hollow conductor 24 of the construction type shown in the figures, with an optical imaging system in form of a lens or in form of an imaging mirror.
Generally it is advantageous if the infrared detector 20 is integrated into the measuring and evaluation electronics 15 in such a manner that a rigid mechanic connection is provided between the infrared detector 20 and the further components of the measuring and evaluation electronics 15. Short and mechanically rigid conductor connections between the infrared detector 20 and the further components of the measuring and evaluation electronics 15 do not only allow a compact design, but also provide high mechanic and electrical stability as well as a good long-term reliability.
At first glance it seems disadvantageous that the transmission path shown in dotted line in figure 2 which the IR radiation must travel from the test zone 7 to the infrared detector 20 is relatively long and not straight.
This is particularly true if the evaluation instrument has a very flat design which is desirable (for easy handling) in practical use, but does not allow to arrange the test element holder 5 above the electronic unit 15.
Additional problems arise if the test element and the holder of the evaluation instrument are formed - as shown - in such a manner that the test element 3, when in the measuring position, sticks out of the housing 23 of the evaluation instrument 2. Such a design is advantageous for the handling of the analysis system, since the sample can be provided to the test zone 7 while the test element is already in the measuring position. However, for the determination of the temperature in the test zone 7, this implies the disadvantage that the transmission path 21 must pass through a window 26 arranged in the housing 2 and including a section 21a located outside the housing 23.
The infrared transport device, designated as 22, enables even in such difficult cases a selective and sensitive detection of the infrared radiation coming from the test zone 7. In the shown case, it consists of a hollow conductor 24 with IR-reflecting interior walls, and an imaging mirror 25 located inside the housing 23 of the evaluation instrument 2.
The hollow conductor 24 is made from a plastic part which is at least in its interior metal-coated (in particular, gold-plated). By means of this hollow conductor 24, the desired IR transmission path 21 can be realized within the housing 25, in a simple and inexpensive way.
If - as in case of the shown test element analysis system - the IR transmission path 21 includes a section 21a located outside the housing 25 of the evaluation instrument 2, it is advantageous to realize in this section the necessary selective detection of the IR
radiation coming from the test zone 7 by means of an optical imaging system. Preferably a concave imaging mirror 25 as shown in figure 2 is used. The optical window 26 is closed dust-proof, preferably with a pane 28 transparent for infrared radiation, in particular a polyethylene sheet.
Figure 3 shows an alternative embodiment in which the optical imaging system is formed by an optical lens integrated into the pane 28, whereas the required beam deflection of the IR radiation on the transmission path 21 is provided by a plane mirror 29.
In the embodiments shown in figures 2 and 3, the function of the location-selective light transport device 22 is essentially based on the effect of an optical imaging system realized by the imaging mirror 25 or the lens 27.
Inside hollow conductor 24 the light path is mainly influenced by the rear, inclined surface which acts as a 5 plane mirror 30 and essentially effects the required deflection to the IR detector 20.
A very effective and at the same time very inexpensive realization of the location-selective IR transport device can be provided (even without an optical imaging system) 10 by means of a hollow conductor with mirror-coated interior, which is designed in such a manner - as shown in figures 4 and 5 - that the input opening 31 facing the test zone 7 has a larger opening cross-section than the output opening 32 facing the infrared detector. In such an embodiment it is advantageous if the hollow conductor 24 tapers continuously between the input opening 31 and the output opening 32, i.e. its cross-section decreases gradually along the path. In this way a concentration of the infrared radiation intensity reflected at the interior walls of the hollow conductor 24 is provided.
In the embodiment shown in figure 4, the axis of hollow conductor 24 is a straight line. In this case, the light-sensitive surface of the detector 20 is located in a lateral position. However, it is easily possible to produce the hollow conductor 24 in a curved embodiment, as shown in figure 5. Such a curved embodiment enables a particularly flexible design and positioning of the test element 3 with the test zone 7 and of the printed circuit board 16 with the detector 20.
Although figures 4 and 5 do not show an optical imaging system, it is of course possible to combine a hollow conductor 24 of the construction type shown in the figures, with an optical imaging system in form of a lens or in form of an imaging mirror.
Claims (14)
1. Test element analysis system (1) for the analytical investigation of a sample (8), comprising:
a test element (3) with a test zone (7), which is contacted with the sample to be analyzed in order to measure a measurement quantity which is characteristic for the analysis, and an evaluation instrument (2) with a test element holder (5) for positioning the test element (3) in a measuring position in order to perform a measurement, and a measurement and evaluation electronics (15) for measuring the characteristic change and for determining, based on this measurement, a result of the analysis, characterized in that the evaluation instrument (2) comprises an infrared detector (20) for the determination of the temperature in the test zone (7) of the test element (3).
a test element (3) with a test zone (7), which is contacted with the sample to be analyzed in order to measure a measurement quantity which is characteristic for the analysis, and an evaluation instrument (2) with a test element holder (5) for positioning the test element (3) in a measuring position in order to perform a measurement, and a measurement and evaluation electronics (15) for measuring the characteristic change and for determining, based on this measurement, a result of the analysis, characterized in that the evaluation instrument (2) comprises an infrared detector (20) for the determination of the temperature in the test zone (7) of the test element (3).
2. Analysis system according to claim 1, characterized is that the infrared detector (20) is integrated into the measuring and evaluation electronics (15).
3. Analysis system according to claim 1 or 2, characterized in that the evaluation instrument (2) comprises an infrared radiation transport device (22) for providing a location-selective connection of the test zone (7) with the infrared detector (20).
4. Analysis system according to claim 3, characterized in that the infrared radiation transport device (22) comprises a hollow conductor (24) with an interior wall reflective for infrared radiation.
5. Analysis system according to claim 4, characterized in that the hollow conductor (24) is made from metal-coated plastic.
6. Analysis system according to claim 4 or 5, characterized in that an input opening (31) of the hollow conductor (24) facing the test zone (7) has a larger opening cross-section than an output opening (32) of the hollow conductor (24) facing the infrared detector (20).
7. Analysis system according to any one of claims 3 to 6, characterized in that the location-selective infrared radiation transport device (22) includes an imaging mirror (25) located inside the housing (23) of the evaluation instrument.
8. Analysis system according to any one of claims 1 to 7, characterized in that the test element (3), in the measuring position, sticks out of the housing (23) of the evaluation instrument (2) in such a manner that the sample (8) can be contacted to the test zone (7), while the test element is in the measuring position, the detector (20) is located in the housing (23), the housing (23) comprises a window (26) which is transparent for infrared radiation, and a transport path (21) of the infrared radiation between the test zone (7) and the infrared detector (20) passes through the optical window (26).
9. Analysis system according to claim 8, characterized in that the optical window (26) is dust-proof closed by means of a pane (28) transparent to infrared radiation.
10. Analysis system according to claim 9, characterized in that the pane (28) is a polyethylene foil.
11. Analysis system according to claim 3, characterized in that the test element (3), in the measuring position, sticks out of the housing (23) of the evaluation instrument (2) in such a manner that the sample (8) can be contacted to the test zone (7), while the test element is in the measuring position, the detector (20) is located in the housing (23), the housing (23) comprises a window (26) which is transparent for infrared radiation, and a transport path (21) of the infrared radiation between the test zone (7) and the infrared detector (20) passes through the optical window (26); and an infrared transparent radiation pane (28) of the optical window (26) is combined with an optical lens (27) forming a part of the infrared radiation transport device (22).
12. Analysis system according to claim 11, characterized in that the pane (28) is a polyethylene foil.
13. Analysis system according to any one of claims 1 to 12, for the analytical investigation of a sample of a body liquid of humans or animals.
14. Use of an analysis system according to any one of claims 1 to 12, in the analytical investigation of a sample of a body liquid of humans or animals.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19952215A DE19952215C2 (en) | 1999-10-29 | 1999-10-29 | Test element analysis system |
DE19952215.4 | 1999-10-29 | ||
PCT/DE2000/003804 WO2001033214A2 (en) | 1999-10-29 | 2000-10-26 | Test element analysis system with an infrared detector |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2387728A1 CA2387728A1 (en) | 2001-05-10 |
CA2387728C true CA2387728C (en) | 2009-01-06 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CA002387728A Expired - Fee Related CA2387728C (en) | 1999-10-29 | 2000-10-26 | Test element analysis system with an infrared detector |
Country Status (7)
Country | Link |
---|---|
US (1) | US6880968B1 (en) |
EP (1) | EP1238274B1 (en) |
JP (1) | JP3723772B2 (en) |
AT (1) | ATE269542T1 (en) |
CA (1) | CA2387728C (en) |
DE (3) | DE19952215C2 (en) |
WO (1) | WO2001033214A2 (en) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
DE10032015A1 (en) * | 2000-07-01 | 2002-01-10 | Roche Diagnostics Gmbh | Test strip analysis unit for bodily fluid, employs temperature history correction system which will not drain batteries |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US7041068B2 (en) | 2001-06-12 | 2006-05-09 | Pelikan Technologies, Inc. | Sampling module device and method |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
ES2357887T3 (en) | 2001-06-12 | 2011-05-03 | Pelikan Technologies Inc. | APPARATUS FOR IMPROVING THE BLOOD OBTAINING SUCCESS RATE FROM A CAPILLARY PUNCTURE. |
AU2002348683A1 (en) | 2001-06-12 | 2002-12-23 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
EP1404232B1 (en) | 2001-06-12 | 2009-12-02 | Pelikan Technologies Inc. | Blood sampling apparatus and method |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
US7316700B2 (en) | 2001-06-12 | 2008-01-08 | Pelikan Technologies, Inc. | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
WO2002100460A2 (en) | 2001-06-12 | 2002-12-19 | Pelikan Technologies, Inc. | Electric lancet actuator |
ITMI20012828A1 (en) | 2001-12-28 | 2003-06-28 | Gambro Dasco Spa | NON-INVASIVE DEVICE FOR THE DETECTION OF BLOOD TEMPERATURE IN A CIRCUIT FOR THE EXTRACORPOREAL BLOOD CIRCULATION AND APPARATUS |
US7655456B2 (en) | 2002-01-18 | 2010-02-02 | Arkray, Inc. | Analytical device having temperature detection unit |
US7708701B2 (en) | 2002-04-19 | 2010-05-04 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device |
US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
US7371247B2 (en) | 2002-04-19 | 2008-05-13 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7291117B2 (en) | 2002-04-19 | 2007-11-06 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7175642B2 (en) | 2002-04-19 | 2007-02-13 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
US7717863B2 (en) | 2002-04-19 | 2010-05-18 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7648468B2 (en) | 2002-04-19 | 2010-01-19 | Pelikon Technologies, Inc. | Method and apparatus for penetrating tissue |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
SE523545C2 (en) * | 2002-09-19 | 2004-04-27 | Foss Tecator Ab | Method, a portable device and a measuring instrument for standardizing a satellite measuring instrument to a corresponding main measuring instrument |
DE10253934C1 (en) * | 2002-11-19 | 2003-12-04 | Seleon Gmbh | Continuous positive airway pressure respiration device with selective illumination of display and/or operating controls under control of sensor signal |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
EP1443325A1 (en) * | 2003-02-01 | 2004-08-04 | Roche Diagnostics GmbH | System and method for determining a coagulation parameter |
US7850621B2 (en) | 2003-06-06 | 2010-12-14 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
WO2005033659A2 (en) | 2003-09-29 | 2005-04-14 | Pelikan Technologies, Inc. | Method and apparatus for an improved sample capture device |
US9351680B2 (en) | 2003-10-14 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a variable user interface |
US7444005B2 (en) * | 2003-11-04 | 2008-10-28 | Becton, Dickinson And Company | Apparatus and method for using optical mouse engine to determine speed, direction, position of scanned device and to obtain quantitative or qualitative data from same |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
US8668656B2 (en) | 2003-12-31 | 2014-03-11 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for improving fluidic flow and sample capture |
US20050227370A1 (en) * | 2004-03-08 | 2005-10-13 | Ramel Urs A | Body fluid analyte meter & cartridge system for performing combined general chemical and specific binding assays |
US8828203B2 (en) | 2004-05-20 | 2014-09-09 | Sanofi-Aventis Deutschland Gmbh | Printable hydrogels for biosensors |
EP1765194A4 (en) | 2004-06-03 | 2010-09-29 | Pelikan Technologies Inc | Method and apparatus for a fluid sampling device |
US8003049B2 (en) | 2004-09-30 | 2011-08-23 | Arkray, Inc. | Analyzer |
WO2006070199A1 (en) * | 2004-12-29 | 2006-07-06 | Lifescan Scotland Limited | An analyte test meter having a test sensor port |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
EP1813937A1 (en) * | 2006-01-25 | 2007-08-01 | Roche Diagnostics GmbH | Electrochemical biosensor analysis system |
US7947222B2 (en) * | 2006-08-15 | 2011-05-24 | Infopia Co., Ltd. | Mobile communication terminal equipped with temperature compensation function for use in bio-information measurement |
EP1889568A1 (en) | 2006-08-16 | 2008-02-20 | Infopia Co., Ltd. | Mobile communication terminal equipped with temperature compensation function for use in bioinformation measurement |
ES2712778T3 (en) | 2007-05-30 | 2019-05-14 | Ascensia Diabetes Care Holdings Ag | Method and system to manage health data |
EP2203725A4 (en) | 2007-10-15 | 2011-04-20 | Bayer Healthcare Llc | Method and assembly for determining the temperature of a test sensor |
US9386944B2 (en) | 2008-04-11 | 2016-07-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte detecting device |
JP5540001B2 (en) * | 2008-10-21 | 2014-07-02 | ライフスキャン・インコーポレイテッド | Multiple temperature measurement with modeling |
EP2350585A4 (en) * | 2008-10-21 | 2014-12-03 | Lifescan Inc | Infrared temperature measurement of strip |
PL2380009T3 (en) * | 2008-12-18 | 2015-07-31 | Bayer Healthcare Llc | Assembly for determining the temperature of a test sensor |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
JP2012520994A (en) * | 2009-03-20 | 2012-09-10 | エフ.ホフマン−ラ ロシュ アーゲー | Test elements and methods for measuring body fluids |
WO2010144441A1 (en) * | 2009-06-08 | 2010-12-16 | Bayer Healthcare Llc | Method and assembly for determining the temperature of a test sensor |
JP5270501B2 (en) * | 2009-09-17 | 2013-08-21 | テルモ株式会社 | Blood glucose meter and blood glucose level measuring method |
US9326708B2 (en) * | 2010-03-26 | 2016-05-03 | Medtronic Minimed, Inc. | Ambient temperature sensor systems and methods |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8275413B1 (en) * | 2011-09-17 | 2012-09-25 | Fraden Corp. | Wireless communication device with integrated electromagnetic radiation sensors |
WO2013065248A1 (en) * | 2011-11-01 | 2013-05-10 | パナソニック株式会社 | Biological sample measuring apparatus |
WO2015141510A1 (en) * | 2014-03-20 | 2015-09-24 | パナソニックヘルスケアホールディングス株式会社 | Biological information measurement device and method for controlling biological information measurement device |
US20180095049A1 (en) * | 2016-09-30 | 2018-04-05 | Lifescan Scotland Limited | Hand-held test meter with analytical test strip contact pressure feature |
Family Cites Families (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4360723A (en) * | 1979-10-31 | 1982-11-23 | Tokyo Shibaura Denki Kabushiki Kaisha | Microwave oven |
DE3011223C2 (en) | 1980-03-22 | 1983-04-14 | Clinicon Mannheim GmbH, 6800 Mannheim | Device for positioning and holding a test strip for optical medical measurements |
CA1168064A (en) | 1980-03-22 | 1984-05-29 | Klaus Nenninger | Device for positioning a test strip for optical- medical measurements |
DE3321783A1 (en) | 1983-06-16 | 1984-12-20 | Boehringer Mannheim Gmbh, 6800 Mannheim | ARRANGEMENT FOR EVALUATING A TEST STRIP |
DE3742786A1 (en) | 1987-12-17 | 1989-06-29 | Boehringer Mannheim Gmbh | ANALYSIS SYSTEM FOR DETERMINING A COMPONENT OF A LIQUID |
US4947850A (en) * | 1988-03-11 | 1990-08-14 | Trustees Of The University Of Pennsylvania | Method and apparatus for imaging an internal body portion of a host animal |
US4993419A (en) * | 1988-12-06 | 1991-02-19 | Exergen Corporation | Radiation detector suitable for tympanic temperature measurement |
US4988211A (en) * | 1989-04-27 | 1991-01-29 | The Dow Chemical Company | Process and apparatus for contactless measurement of sample temperature |
US5095913A (en) * | 1989-09-01 | 1992-03-17 | Critikon, Inc. | Shutterless optically stabilized capnograph |
US5578499A (en) * | 1989-09-20 | 1996-11-26 | The Royal Institution For The Advancement Of Learning | Homogeneous immunoassay system employing fourier transform infrared spectroscopy |
US5313941A (en) * | 1993-01-28 | 1994-05-24 | Braig James R | Noninvasive pulsed infrared spectrophotometer |
US5405511A (en) * | 1993-06-08 | 1995-04-11 | Boehringer Mannheim Corporation | Biosensing meter with ambient temperature estimation method and system |
WO1995022928A1 (en) * | 1994-02-28 | 1995-08-31 | Economation, Inc. | Infrared tympanic thermometer |
US5626139A (en) * | 1994-09-23 | 1997-05-06 | Artech Industries, Inc. | Tympanic thermometer |
US5695949A (en) * | 1995-04-07 | 1997-12-09 | Lxn Corp. | Combined assay for current glucose level and intermediate or long-term glycemic control |
EP0801926A4 (en) | 1995-11-13 | 1999-05-26 | Citizen Watch Co Ltd | Clinical radiation thermometer |
US5820264A (en) | 1996-03-25 | 1998-10-13 | Oriental System Technology, Inc. | Tympanic thermometer arrangement |
JPH10142066A (en) | 1996-11-06 | 1998-05-29 | Nikon Corp | Observing apparatus |
JP3368159B2 (en) * | 1996-11-20 | 2003-01-20 | 東京エレクトロン株式会社 | Plasma processing equipment |
US5972715A (en) | 1996-12-23 | 1999-10-26 | Bayer Corporation | Use of thermochromic liquid crystals in reflectometry based diagnostic methods |
JPH10227699A (en) | 1997-02-14 | 1998-08-25 | Matsushita Electric Ind Co Ltd | Noncontact temperature measuring sensor |
US5823966A (en) * | 1997-05-20 | 1998-10-20 | Buchert; Janusz Michal | Non-invasive continuous blood glucose monitoring |
US5985675A (en) * | 1997-12-31 | 1999-11-16 | Charm Sciences, Inc. | Test device for detection of an analyte |
US6066243A (en) * | 1997-07-22 | 2000-05-23 | Diametrics Medical, Inc. | Portable immediate response medical analyzer having multiple testing modules |
DE19733445A1 (en) * | 1997-08-02 | 1999-02-18 | Boehringer Mannheim Gmbh | Analysis appts. with time counter and data processor for blood glucose level monitoring |
WO1999006822A1 (en) * | 1997-08-04 | 1999-02-11 | Kyoto Daiichi Kagaku Co., Ltd. | Clinical examination apparatus and method |
CA2547296C (en) * | 1997-12-04 | 2010-08-24 | Roche Diagnostics Corporation | Apparatus for determining concentration of medical component |
DE19810163A1 (en) | 1998-03-05 | 1999-09-30 | Valco Cincinnati Gmbh | Device for the detection of water and water-containing substances, in particular water-containing adhesives, on surfaces of any materials |
US6302855B1 (en) * | 1998-05-20 | 2001-10-16 | Novo Nordisk A/S | Medical apparatus for use by a patient for medical self treatment of diabetes |
US6201245B1 (en) * | 1998-06-18 | 2001-03-13 | Robert J. Schrader | Infrared, multiple gas analyzer and methods for gas analysis |
US6518034B1 (en) * | 1998-06-25 | 2003-02-11 | Abb Diagnostics, Ltd. | Test strip for blood glucose determination |
US6261519B1 (en) * | 1998-07-20 | 2001-07-17 | Lifescan, Inc. | Medical diagnostic device with enough-sample indicator |
US6084660A (en) * | 1998-07-20 | 2000-07-04 | Lifescan, Inc. | Initiation of an analytical measurement in blood |
US6087182A (en) * | 1998-08-27 | 2000-07-11 | Abbott Laboratories | Reagentless analysis of biological samples |
US6424851B1 (en) * | 1998-10-13 | 2002-07-23 | Medoptix, Inc. | Infrared ATR glucose measurement system (II) |
US6136610A (en) * | 1998-11-23 | 2000-10-24 | Praxsys Biosystems, Inc. | Method and apparatus for performing a lateral flow assay |
US6167290A (en) * | 1999-02-03 | 2000-12-26 | Bayspec, Inc. | Method and apparatus of non-invasive measurement of human/animal blood glucose and other metabolites |
DE59913262D1 (en) * | 1999-07-08 | 2006-05-11 | Leonhardt Steffen | DEVICE FOR MEASURING HUMAN BLOOD SUGAR MIRROR |
US6133552A (en) * | 1999-08-11 | 2000-10-17 | General Electric Company | Sensor assembly for glass-ceramic cooktop appliance and method of calibrating |
US6320170B1 (en) * | 1999-09-17 | 2001-11-20 | Cem Corporation | Microwave volatiles analyzer with high efficiency cavity |
US20020048307A1 (en) * | 2000-09-14 | 2002-04-25 | Volker Schmidt | Device and process for infrared temperature measurement |
US6541266B2 (en) * | 2001-02-28 | 2003-04-01 | Home Diagnostics, Inc. | Method for determining concentration of an analyte in a test strip |
US6898451B2 (en) * | 2001-03-21 | 2005-05-24 | Minformed, L.L.C. | Non-invasive blood analyte measuring system and method utilizing optical absorption |
US7041468B2 (en) * | 2001-04-02 | 2006-05-09 | Therasense, Inc. | Blood glucose tracking apparatus and methods |
US20040147034A1 (en) * | 2001-08-14 | 2004-07-29 | Gore Jay Prabhakar | Method and apparatus for measuring a substance in a biological sample |
US6678542B2 (en) * | 2001-08-16 | 2004-01-13 | Optiscan Biomedical Corp. | Calibrator configured for use with noninvasive analyte-concentration monitor and employing traditional measurements |
AU2002348199A1 (en) * | 2001-11-09 | 2003-05-19 | Dow Global Technologies Inc. | An enzyme-based system and sensor for measuring acetone |
US7811231B2 (en) * | 2002-12-31 | 2010-10-12 | Abbott Diabetes Care Inc. | Continuous glucose monitoring system and methods of use |
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WO2001033214A2 (en) | 2001-05-10 |
JP3723772B2 (en) | 2005-12-07 |
DE10083447D2 (en) | 2002-12-05 |
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