CA2390032A1 - Ingestible device for the release of substances at distinct locations in the alimentary canal - Google Patents

Ingestible device for the release of substances at distinct locations in the alimentary canal Download PDF

Info

Publication number
CA2390032A1
CA2390032A1 CA002390032A CA2390032A CA2390032A1 CA 2390032 A1 CA2390032 A1 CA 2390032A1 CA 002390032 A CA002390032 A CA 002390032A CA 2390032 A CA2390032 A CA 2390032A CA 2390032 A1 CA2390032 A1 CA 2390032A1
Authority
CA
Canada
Prior art keywords
substance
latch
actuator mechanism
receiver
reservoir
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002390032A
Other languages
French (fr)
Other versions
CA2390032C (en
Inventor
Peter John Houzego
Duncan James Westland
Peter Neil Morgan
Ian Robert Wilding
Peter Hanson Hirst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phaeton Research Ltd
Original Assignee
Peter John Houzego
Duncan James Westland
Peter Neil Morgan
Ian Robert Wilding
Peter Hanson Hirst
Phaeton Research Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peter John Houzego, Duncan James Westland, Peter Neil Morgan, Ian Robert Wilding, Peter Hanson Hirst, Phaeton Research Ltd filed Critical Peter John Houzego
Publication of CA2390032A1 publication Critical patent/CA2390032A1/en
Application granted granted Critical
Publication of CA2390032C publication Critical patent/CA2390032C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0001—Means for transferring electromagnetic energy to implants
    • A61F2250/0002—Means for transferring electromagnetic energy to implants for data transfer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3507—Communication with implanted devices, e.g. external control
    • A61M2205/3523—Communication with implanted devices, e.g. external control using telemetric means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1042—Alimentary tract

Abstract

An ingestible device (10) for delivering a substance (12a) to a chosen location in the GI tract of a mammal includes a receiver of electromagnetic radiation for powering an openable part of the device (10) to an opened position for dispensing of the substance (12a). The receiver includes a coil ed wire (29) that couples the energy field, the wire (29) having an air or ferrite (36) core. In a further embodiment the invention includes an apparat us for generating the electromagnetic radiation, the apparatus including one or more pairs of field coils (42) supported in a housing. The device (10) optionally includes a latch defined by a heating resistor (20) and a fusible restraint (19). The device (10) may also include a flexible member (51) that may serve the function of activating a transmitter circuit (28) to indicate dispensing of the substance; and means restraining a piston (16) used for expelling the substance.

Claims (71)

1. An ingestible device for delivering a substance to a chosen or identifiable location in the alimentary canal of a human or animal, comprising an openable reservoir, for the substance, that is sealable against leakage of the substance;
an actuator mechanism for opening the reservoir;
an energy source, operatively connected for powering the actuator mechanism;
a releasable latch for controllably switching the application of power to the actuator from the energy source; and a receiver of electromagnetic radiation, for operating the latch when the receiver detects radiation within a predetermined characteristic range, the receiver including an air core having coiled therearound a wire;
characterised in that the coiled wire lies on or is embedded in an outer wall of the device.
2. A device according to Claim 1 wherein the diameter of the coils of the wire is in the range 8-l2mm and its length is in the range 10-20mm.
3. An ingestible device for delivering a substance to a chosen or identifiable location in the alimentary canal of a human or animal, comprising an openable reservoir, for the substance, that is sealable against leakage of the substance;
an actuator mechanism for opening the reservoir;
an energy source, operatively connected for powering the actuator mechanism;
a releasable latch for controllably switching the application of power to the actuator from the energy source; and a receiver of electromagnetic radiation, for operating the latch when the receiver detects radiation within a predetermined characteristic range, the device including a ferrite core having coiled theraround a wire for coupling received electromagnetic radiation to the releasable latch, characterised in that the device comprises an elongate, hollow housing, the ferrite core being elongate with its longitudinal axis aligned with the longitudinal axis of the hollow housing.
4. A device according to any of Claims 1 to 3, wherein the receiver includes the said ferrite core and coil.
5. A device according to any preceding claim, wherein the air or ferrite core and coil are spaced from any fluid within or outside the device by a distance of 0.1 mm to 1 mm.
6. A device according to any preceding claim, including a transmitter having an air or ferrite core having coiled therearound a wire for transmitting electromagnetic radiation.
7. An apparatus for transmitting electromagnetic radiation to power an ingestible device, the apparatus comprising:
a support supporting a pair of transmitter coils including one or more loops operatively connectable to a source of oscillating electrical current, the support supporting the respective coils of the pair on opposite sides of the abdomen of an animal.
8. An apparatus according to Claim 7 wherein the coils define a Helmholtz pair.
9. An apparatus according to Claim 7, wherein the loops of the pair of coils are each of generally the same radius and are spaced from one another by between one and four times the said radius.
10. An apparatus according to Claim 9, wherein the loops are spaced from one another by twice the said radius.
11. An apparatus according to Claim 9 or Claim 10, wherein the spacing between the loops lies in the range 400mm - 800mm.
12. An apparatus according to any of Claims 7 to 11 including three said coil pairs supported on the support whereby to provide three mutually skewed fields.
13. An apparatus according to Claim 12 wherein the coil pairs provide three mutually orthogonal fields.
14. An apparatus according to any of Claims 7 to 13 wherein the frequency of the oscillating field generated by the or each coil pair is in the range 1 MHz - 14MHz.
15. An apparatus according to Claim 14 wherein the said frequency is in the range 1 MHz - 3MHz.
16. An apparatus according to any of Claims 7 to 15 including shielding that inhibits the transmission of short wave electrostatic radiation.
17. An apparatus according to any of Claims 7 to 16 including shielding that inhibits the transmission of long wave radio waves.
18. An apparatus according to any of Claims 7 to 17 wherein the support is or includes a wearable garment.
19. An apparatus according to any of Claims 7 to 17 wherein the support includes a framework supporting one or more of the coil pairs, the framework permitting the abdomen of a mammal to intercept the magnetic field from the or each Helmholtz pair.
20. An apparatus according to Claim 19 wherein the framework includes at least one releasably securable member supporting a said loop, thereby permitting a mammal to enter and leave the vicinity of the or each magnetic field.
21. An apparatus according to any of Claims 7 to 20 wherein the spacing between the or at least one said pair of loops is adjustable.
22. An apparatus according to any of Claims 7 to 21 wherein the size and/or position of the field coils of the or at least one said coil pair determine the frequency of oscillation of the magnetic field generated thereby.
23. An apparatus according to any of Claims 7 to 20 wherein each loop of a said coil pair includes between 1 and 10 turns.
24. An apparatus according to any of Claims 7 to 23 wherein each loop defines at least part of the frequency determining stage of a power oscillator.
25. An apparatus according to any of Claims 7 to 24 wherein at least one of the said coils includes a capacitor oscillator operatively connected in parallel therewith whereby to provide a different resonant frequency, of the said coil, than that of the remainder of the coils.
26. A method of operating an ingestible device for delivering a substance to a chosen or identifiable location in the alimentary canal of a human or animal, causing a mammal to ingest an ingestible device comprising an openable reservoir, for the substance, that is sealable against leakage of the substance;
an actuator mechanism for opening the reservoir;
an energy source, operatively connected for powering the actuator mechanism;
a releasable latch for controllably switching the application of power to the actuator from the energy source; and a receiver of electromagnetic radiation, for operating the latch when the receiver detects radiation within a predetermined characteristic range;
the receiver being capable of extracting energy from an oscillating magnetic field and the method comprising:
at a chosen time, generating at least one axial, oscillating magnetic field and directing the field at the abdomen of the mammal whereby the receiver intercepts the said field and triggers the latch to cause opening of the reservoir; and simultaneously inhibiting the generation of long wave radio waves and short wave electrostatic radiation in the vicinity of the said abdomen.
27. A method according to Claim 26 including the step of generating two or more axial, oscillating magnetic fields whose axes are mutually skewed.
28. A method according to Claim 27 including the step of generating three said fields, wherein the axes of the said fields are mutually orthogonal.
29. A method according to any of Claims 26 to 28 wherein the or each said field is generated using a coil pair operatively connected to a source of an oscillating current.
30. An ingestible device for delivering a substance to a chosen or identifiable location in the alimentary canal of a human or animal, comprising an openable reservoir, for the substance, that is sealable against leakage of the substance;
an actuator mechanism for opening the reservoir;
an energy source, operatively connected for powering the actuator mechanism;
a releasable latch for controllably switching the application of power to the actuator mechanism from the energy source;
a receiver of electromagnetic radiation, for operating the latch when the receiver detects radiation within a predetermined characteristic range;
and a transmitter of electromagnetic radiation for transmitting a signal indicative of operation of the device, the said reservoir including an exit aperture, for the substance, closed by a closure member that is sealingly retained relative to the aperture, the exit aperture being openable on operation of the actuator mechanism;
wherein:
(i) the latch is thermally actuated;
(ii) the energy source is held in a potential energy state by the latch until the latch operates; and (iii) the device includes a heater for heating the latch whereby, on the receiver detecting the said radiation the receiver operates to power the heater and thereby release the latch, permitting expulsion of the substance from the reservoir; characterised in that:

the device also includes a restraint operable to limit operation of the actuator mechanism; and in that, on release of the latch, the restraint operates a switch to activate the transmitter for transmission of a said signal.
31. A device according to Claim 30 wherein:
the actuator mechanism includes a moveable member moveable under power of kinetic energy from the energy source to promote expulsion of the substance from the reservoir;
the restraint includes a flexible member interconnecting the moveable member and an anchorage fixed relative to the remainder of the device; and the switch includes a breakable, electrically conductive member, the flexible member and the breakable member being mutually engageable whereby on movement of the moveable member sufficiently partly or completely to expel or initiate expulsion of the substance from the reservoir the flexible member engages and breaks the breakable member to operate the switch.
32. A device according to Claim 30 or Claim 31 wherein the actuator mechanism includes a piston moveable under power from the energy source for compressing the substance in the reservoir to promote its expulsion therefrom.
33. A device according to any of Claim 30 to 32 wherein the transmitter includes a resonant circuit connectable to draw power from the receiver; and the breakable member is an electrical short that electrically isolates the resonant circuit from the receiver until the flexible member breaks the breakable member.
34. A device according to any of Claims 30 to 33 wherein the length of the flexible member is such as to limit the travel of the moveable member to a chosen maximum.
35. A device according to any of Claims 30 to 34 wherein the restraint and the switch are so dimensioned and/or located that the restraint operates the switch at a time corresponding to a predetermined amount of movement of the moveable member.
36. An ingestible device for delivering a substance to a chosen or identifiable location in the alimentary canal of a human or animal, comprising an openable reservoir, for the substance, that is sealable against leakage of the substance;
an actuator mechanism for opening the reservoir;
an energy source, operatively connected for powering the actuator mechanism;
a releasable latch for controllably switching the application of power to the actuator from the energy source; and a receiver of electromagnetic radiation, for operating the latch when the receiver detects radiation within a predetermined characteristic range;
the energy source including a compressed spring capable of acting on the actuator mechanism the expansion of the spring being initiatable by the latch and the work of the expansion of the spring causing operation of the actuator mechanism, characterised in that the spring, in its uncompressed state, is of a hollow, cylinder-like shape and in that the helical angle subtended between adjacent coils of the spring is a minimum of 15°.
37. A device according to Claim 36 wherein the spring includes a wire whose diameter is approximately 0.8mm.
38. A device according to Claim 36 or Claim 37 wherein the spring defines a hollow cylinder.
39. An ingestible device for delivering a substance to a chosen or identifiable location in the alimentary canal of a human or animal, comprising an openable reservoir, for the substance, that is sealable against leakage of the substance;
an actuator mechanism for opening the reservoir;
an energy source, operatively connected for powering the actuator mechanism;
a releasable latch for controllably switching the application of power to the actuator from the energy source; and a receiver of electromagnetic radiation, for operating the latch when the receiver detects radiation within a predetermined characteristic range;
the energy source including a compressed spring capable of acting on the actuator mechanism the expansion of the spring being initiatable by the latch and the work of the expansion of which causes operation of the actuator mechanism, the spring including a pair of wires each coiled in loops to define a pair of hollow cylinder-like shapes, a first said cylinder-like shape being of a greater internal diameter than the outer diameter of the second said cylinder-like shape and the first cylinder-like shape encircling the second cylinder-like shape, characterised in that each spring of the said pair is coated with an insulator over at least part of its length, to insulate the springs from one another in use.
40. A device according to Claim 39 wherein the wire of the first cylinder-like shape is looped in a clockwise direction and the wire of the second cylinder-like shape is looped in an anticlockwise direction; or vice versa.
41. A device according to Claim 40 wherein the wires of the first and second cylinder-like shapes are wound in the same direction.
42. A device according to any of Claim 39 to 41 wherein the first and second cylinder-like shapes are spaced from one another in the radial direction of the spring cross section.
43. A device according to any of Claims 39 to 42 wherein at least one of the wires includes a coating of an insulator over at least part of its length, whereby to insulate it from the other said wire.
44. A device according to any of Claims 39 to 43 wherein the ends of the wires defining each said wire are flush with the adjacent loops thereof.
45. A device according to any of Claims 39 to 44 wherein the compressed length of the spring is approximately ~, of its length in the uncompressed condition.
46. A device according to any of Claims 39 to 45 wherein the force applied by the spring to the actuator mechanism exceeds the maximum resistive force resisting operation of the actuator, at the time when the maximum resistive force applies.
47. An ingestible device for delivering a substance to a chosen or identifiable location in the alimentary canal of a human or animal, comprising an openable reservoir, for the substance, that is sealable against leakage of the substance;
an actuator mechanism for opening the reservoir;
an energy source, operatively connected for powering the actuator mechanism;
a releasable latch for controllably switching the application of power to the actuator from the energy source; and a receiver of electromagnetic radiation, for operating the latch when the receiver detects radiation within a predetermined characteristic range;
the energy source including a compressed spring the expansion of which is initiatable by the latch and the work of the expansion of which causes operation of the actuator mechanism, characterised in that the spring comprises a stack of resiliently deformable discs, the periphery of each disc having formed therein a series of waves, the waves of respective said discs connecting such that the peak of each wave contacts the trough of a wave of an adjacent said disc.
48. A device according to Claim 47 wherein the waves of each disc radiate generally from its centre.
49. A device according to Claim 47 or Claim 48 wherein each disc is an annulus.
50. A device according to Claim 49 wherein each annulus is about 0.25mm thick and has three said waves, the peak to trough distance of the waves being about 2mm.
51. A device according to Claim 50 wherein the spring includes 16 said annuli secured together at the respective peaks and troughs of the waves.
52. A device according to Claim 49 or any claim dependent therefrom, wherein the outer diameter of each annulus is about 8.5mm and the inner diameter is about 4.5mm.
53. A device according to any of Claims 36 to 52 wherein the actuator mechanism includes a piston moveable under power from the spring for compressing the substance in the reservoir to promote its expulsion therefrom, the spring being engaged at one end directly or indirectly with the piston and secured at its other end to a member fixed relative to the remainder of the device.
54. A device according to Claim 53 when dependent from Claim 39, Claim 39 or Claim 49 wherein the spring encircles one or more further components of the device.
55. A device according to any of Claims 1 to 6 or 30 to 54 including a retainer for retaining moveable components within the device.
56. A device according to Claim 55 wherein the retainer includes a rib that reduces the cross sectional area of the hollow interior of the device in the vicinity of an opening therein.
57. A device according to Claim 53 or any claim dependent from Claim 53 wherein the piston includes a flexible annular lip for slidingly sealingly engaging the interior of the reservoir.
58. A device according to Claim 57 wherein the cross section of the lip tapers towards its free edge.
59. A device according to Claim 57 wherein the cross section of the lip is generally parallel sided.
60. An ingestible device for delivering a substance to a chosen or identifiable location in the alimentary canal of a human or animal, comprising:
an openable reservoir, for the substance, that is sealable against leakage of the substance;
an actuator mechanism for opening the reservoir;
an energy source, operatively connected for powering the actuator mechanism;
a releasable latch for controllably switching the application of power to the actuator from the energy source;
a receiver of electromagnetic radiation, for operating the latch when the receiver detects radiation within a predetermined characteristic range;
and a transmitter of electromagnetic radiation for transmitting a signal indicative of operation of the device;
the said reservoir including an exit aperture, for the substance, closed by a closure member that is sealingly retained relative to the aperture, the exit aperture being openable on operation of the actuator mechanism;
wherein (i) the latch is thermally actuated;
(ii) the energy source is held in a potential energy state by the latch until the latch operates; and (iii) the device includes a heater for heating the latch whereby, on the receiver detecting the said radiation the receiver operates to power the heater and thereby release the latch, permitting expulsion of the substance from the reservoir; characterised in that the device also includes (a) a restraint operable to limit operation of the actuator mechanism;
(b) a switch for switchably operating the transmitter; and (c) a switch member operatively interconnecting the actuator mechanism and the switch such that operation of the actuator mechanism causes the switch member to operate the said switch.
61. A device according to Claim 60 wherein the actuator mechanism includes a moveable member and the switch member includes a lost motion arrangement whereby the moveable member moves before the switch member operates the switch.
62. A device according to Claim 61 wherein the switch member interconnects the moveable member and the switch; and includes a slack, flexible member the slackness of which provides the said lost motion arrangement.
63. A device according to Claim 62 including a pcb having a breakable wire secured at spaced locations thereon to define the switch, the pcb being perforated and the said switch and the said moveable member lying respectively at opposite sides of the pcb; and the switch member including a slack, flexible filament that passes through a perforation in the pcb and including a loop that encloses the breakable wire, the filament being secured to the moveable member whereby when the moveable member moves the filament tightens such that the loop breaks the breakable wire.
64. A device according to Claim 60 or any claim dependent therefrom including a pcb supporting the receiver and the transmitter, the receiver and the transmitter each including a resistor track secured on the pcb, the resistor tracks of the transmitter and receiver lying respectively on opposite sides of the pcb.
65. A device according to Claim 64 wherein the pcb includes one or more perforations in the vicinity of each said resistor track.
66. A device according to Claim 63 or any claim dependent therefrom, wherein a projection protrudes from an edge of a perforation through the pcb; and wherein the latch includes a sharp melting point filament interconnecting the actuator member and the said projection.
67. A device according to Claim 66 wherein the heater is secured to the projection in heat transmitting proximity to the sharp melting point filament.
68. A device according to any of Claims 1 to 6 or 30 to 67 the reservoir of which includes a charge of liquid, powdered or solid substance or a suspension or solution for discharge into the GI tract of a mammal.
69. A device according to any of Claims 1 to 5 or 30 to 68, including a radioisotope tag generating radiation that is detectable for indicating the location of the device in the GI tract of a mammal.
70. A method according to any of Claims 26 to 29, including the step of indicating the location of the device in the GI tract of the mammal, using a radioisotope tag.
71. A method according to Claim 70 wherein the step of indicating the location includes using Gamma scintigraphy to indicate the location of the device in the said GI tract.
CA2390032A 1999-12-21 2000-12-14 Ingestible device for the release of substances at distinct locations in the alimentary canal Expired - Fee Related CA2390032C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9930000.6 1999-12-21
GBGB9930000.6A GB9930000D0 (en) 1999-12-21 1999-12-21 An ingestible device
PCT/GB2000/004814 WO2001045789A2 (en) 1999-12-21 2000-12-14 Ingestible device for the release of substances at distinct locations in the alimentary canal

Publications (2)

Publication Number Publication Date
CA2390032A1 true CA2390032A1 (en) 2001-06-28
CA2390032C CA2390032C (en) 2011-08-23

Family

ID=10866613

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2390032A Expired - Fee Related CA2390032C (en) 1999-12-21 2000-12-14 Ingestible device for the release of substances at distinct locations in the alimentary canal

Country Status (10)

Country Link
US (3) US6632216B2 (en)
EP (3) EP2016898B1 (en)
JP (1) JP2003517902A (en)
AT (2) ATE472970T1 (en)
AU (1) AU2198201A (en)
CA (1) CA2390032C (en)
DE (2) DE60044656D1 (en)
DK (2) DK2016898T3 (en)
GB (1) GB9930000D0 (en)
WO (1) WO2001045789A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006047882A1 (en) * 2004-11-05 2006-05-11 Electronic Dietary Foods Inc. Controlled degradation of expandable polymers in gastric volume reduction treatment

Families Citing this family (291)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10973397B2 (en) 1999-03-01 2021-04-13 West View Research, Llc Computerized information collection and processing apparatus
US8636648B2 (en) * 1999-03-01 2014-01-28 West View Research, Llc Endoscopic smart probe
GB9930001D0 (en) * 1999-12-21 2000-02-09 Phaeton Research Ltd An ingestible device
GB9930000D0 (en) * 1999-12-21 2000-02-09 Phaeton Research Ltd An ingestible device
US8489176B1 (en) 2000-08-21 2013-07-16 Spectrum Dynamics Llc Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures
US8036731B2 (en) * 2001-01-22 2011-10-11 Spectrum Dynamics Llc Ingestible pill for diagnosing a gastrointestinal tract
US8565860B2 (en) 2000-08-21 2013-10-22 Biosensors International Group, Ltd. Radioactive emission detector equipped with a position tracking system
US7826889B2 (en) 2000-08-21 2010-11-02 Spectrum Dynamics Llc Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures
WO2004042546A1 (en) * 2002-11-04 2004-05-21 V-Target Technologies Ltd. Apparatus and methods for imaging and attenuation correction
US8909325B2 (en) 2000-08-21 2014-12-09 Biosensors International Group, Ltd. Radioactive emission detector equipped with a position tracking system and utilization thereof with medical systems and in medical procedures
IL157007A0 (en) 2001-01-22 2004-02-08 Target Technologies Ltd V Ingestible device
DE60228266D1 (en) * 2001-06-18 2008-09-25 Given Imaging Ltd SWITCHABLE IN VIVO CAPSULE WITH A RIGID AND FLEXIBLE SECTION CIRCUIT BOARD
US7160258B2 (en) * 2001-06-26 2007-01-09 Entrack, Inc. Capsule and method for treating or diagnosing the intestinal tract
US6958767B2 (en) * 2002-01-31 2005-10-25 Deepsea Power & Light Company Video pipe inspection system employing non-rotating cable storage drum
US7797033B2 (en) * 2002-04-08 2010-09-14 Smart Pill Corporation Method of using, and determining location of, an ingestible capsule
US20040193229A1 (en) * 2002-05-17 2004-09-30 Medtronic, Inc. Gastric electrical stimulation for treatment of gastro-esophageal reflux disease
US7001329B2 (en) * 2002-07-23 2006-02-21 Pentax Corporation Capsule endoscope guidance system, capsule endoscope holder, and capsule endoscope
WO2004041068A2 (en) * 2002-10-31 2004-05-21 Regents Of The University Of Colorado Guided capsule for wireless endoscopy, biopsy, and drug delivery
CA2505743A1 (en) * 2002-11-14 2004-06-03 Ethicon Endo-Surgery, Inc. Methods and devices for detecting tissue cells
US7833151B2 (en) * 2002-12-26 2010-11-16 Given Imaging Ltd. In vivo imaging device with two imagers
CN100438937C (en) * 2002-12-30 2008-12-03 重庆大学 Mini medicine releasing device
US20040267240A1 (en) * 2003-01-29 2004-12-30 Yossi Gross Active drug delivery in the gastrointestinal tract
KR20050098277A (en) * 2003-01-29 2005-10-11 이-필 파마 리미티드 Active drug delivery in the gastrointestinal tract
DE10310825B3 (en) * 2003-03-07 2004-08-19 Fachhochschule Jena Unit releasing pharmaceutical substances under remote control, includes cavity with magnetic rotor turned by magnetic field to generate heat through friction
US7476224B2 (en) * 2003-03-17 2009-01-13 Petrakis Dennis N Temperature responsive systems
US20070043263A1 (en) * 2003-04-03 2007-02-22 Wakefield Glenn M Simultaneous magnetic control of multiple objects
US20040199054A1 (en) * 2003-04-03 2004-10-07 Wakefield Glenn Mark Magnetically propelled capsule endoscopy
US7620454B2 (en) * 2003-05-19 2009-11-17 Medtronic, Inc. Gastro-electric stimulation for reducing the acidity of gastric secretions or reducing the amounts thereof
US7742818B2 (en) * 2003-05-19 2010-06-22 Medtronic, Inc. Gastro-electric stimulation for increasing the acidity of gastric secretions or increasing the amounts thereof
JP2005074031A (en) * 2003-09-01 2005-03-24 Pentax Corp Capsule endoscope
EP3851030B1 (en) 2003-09-11 2024-01-17 Labrador Diagnostics LLC Medical device for analyte monitoring
EP1681010B1 (en) * 2003-10-27 2012-10-10 Olympus Corporation Capsule type medical device
DE10359981A1 (en) * 2003-12-19 2005-07-21 Siemens Ag System and method for in vivo positioning and orientation determination of an endoscopy capsule or an endo-robot in the context of a wireless endoscopy
US8586932B2 (en) 2004-11-09 2013-11-19 Spectrum Dynamics Llc System and method for radioactive emission measurement
US7176466B2 (en) 2004-01-13 2007-02-13 Spectrum Dynamics Llc Multi-dimensional image reconstruction
US8571881B2 (en) 2004-11-09 2013-10-29 Spectrum Dynamics, Llc Radiopharmaceutical dispensing, administration, and imaging
US7968851B2 (en) 2004-01-13 2011-06-28 Spectrum Dynamics Llc Dynamic spect camera
US9040016B2 (en) 2004-01-13 2015-05-26 Biosensors International Group, Ltd. Diagnostic kit and methods for radioimaging myocardial perfusion
WO2005118659A2 (en) 2004-06-01 2005-12-15 Spectrum Dynamics Llc Methods of view selection for radioactive emission measurements
WO2007010534A2 (en) 2005-07-19 2007-01-25 Spectrum Dynamics Llc Imaging protocols
US9470801B2 (en) 2004-01-13 2016-10-18 Spectrum Dynamics Llc Gating with anatomically varying durations
JP2005245938A (en) * 2004-03-08 2005-09-15 Pentax Corp Clothing for diagnosis, system of clothing for diagnosis and endoscope system
US20050195785A1 (en) * 2004-03-08 2005-09-08 Pentax Corporation Image signal processing device
US7751866B2 (en) * 2004-03-08 2010-07-06 Olympus Corporation Detecting system of position and posture of capsule medical device
JP2005245937A (en) * 2004-03-08 2005-09-15 Pentax Corp Clothing with communication function and endoscope system
JP4054319B2 (en) * 2004-03-29 2008-02-27 オリンパス株式会社 Power supply
US7998060B2 (en) 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling delivery device
US8361013B2 (en) 2004-04-19 2013-01-29 The Invention Science Fund I, Llc Telescoping perfusion management system
US8337482B2 (en) 2004-04-19 2012-12-25 The Invention Science Fund I, Llc System for perfusion management
US7850676B2 (en) 2004-04-19 2010-12-14 The Invention Science Fund I, Llc System with a reservoir for perfusion management
US8353896B2 (en) 2004-04-19 2013-01-15 The Invention Science Fund I, Llc Controllable release nasal system
US8512219B2 (en) 2004-04-19 2013-08-20 The Invention Science Fund I, Llc Bioelectromagnetic interface system
US8000784B2 (en) 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling device
US8024036B2 (en) 2007-03-19 2011-09-20 The Invention Science Fund I, Llc Lumen-traveling biological interface device and method of use
US8092549B2 (en) 2004-09-24 2012-01-10 The Invention Science Fund I, Llc Ciliated stent-like-system
US9011329B2 (en) 2004-04-19 2015-04-21 Searete Llc Lumenally-active device
EP1778957A4 (en) 2004-06-01 2015-12-23 Biosensors Int Group Ltd Radioactive-emission-measurement optimization to specific body structures
US8518022B2 (en) 2004-08-27 2013-08-27 Medimetrics Personalized Drug Delivery, Inc. Electronically and remotely controlled pill and system for delivering at least one medicament
US8000773B2 (en) 2004-11-09 2011-08-16 Spectrum Dynamics Llc Radioimaging
US9943274B2 (en) 2004-11-09 2018-04-17 Spectrum Dynamics Medical Limited Radioimaging using low dose isotope
US8615405B2 (en) 2004-11-09 2013-12-24 Biosensors International Group, Ltd. Imaging system customization using data from radiopharmaceutical-associated data carrier
US9316743B2 (en) 2004-11-09 2016-04-19 Biosensors International Group, Ltd. System and method for radioactive emission measurement
EP1827505A4 (en) 2004-11-09 2017-07-12 Biosensors International Group, Ltd. Radioimaging
WO2008059489A2 (en) 2006-11-13 2008-05-22 Spectrum Dynamics Llc Radioimaging applications of and novel formulations of teboroxime
WO2006064502A2 (en) * 2004-12-14 2006-06-22 E-Pill Pharma, Ltd. Local delivery of drugs or substances using electronic permeability increase
EP1844351A4 (en) * 2005-01-13 2017-07-05 Biosensors International Group, Ltd. Multi-dimensional image reconstruction and analysis for expert-system diagnosis
US7585275B2 (en) * 2005-01-18 2009-09-08 Hoya Corporation Capsule endoscope
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
US9198608B2 (en) 2005-04-28 2015-12-01 Proteus Digital Health, Inc. Communication system incorporated in a container
US8912908B2 (en) 2005-04-28 2014-12-16 Proteus Digital Health, Inc. Communication system with remote activation
US8802183B2 (en) 2005-04-28 2014-08-12 Proteus Digital Health, Inc. Communication system with enhanced partial power source and method of manufacturing same
US8836513B2 (en) 2006-04-28 2014-09-16 Proteus Digital Health, Inc. Communication system incorporated in an ingestible product
US8730031B2 (en) 2005-04-28 2014-05-20 Proteus Digital Health, Inc. Communication system using an implantable device
US20060264783A1 (en) 2005-05-09 2006-11-23 Holmes Elizabeth A Systems and methods for monitoring pharmacological parameters
JP2008540023A (en) * 2005-05-19 2008-11-20 イー−ピル ファーマ リミティド Ingestible device for nitric oxide production in tissues
US7382263B2 (en) * 2005-05-20 2008-06-03 Dow Global Technologies Inc. Oral drug compliance monitoring using radio frequency identification tags
US8837793B2 (en) 2005-07-19 2014-09-16 Biosensors International Group, Ltd. Reconstruction stabilizer and active vision
EP1908011B1 (en) 2005-07-19 2013-09-04 Spectrum Dynamics LLC Reconstruction stabilizer and active vision
JP5341513B2 (en) * 2005-07-20 2013-11-13 ニール・アール．・イウリアーノ Medication compliance system and related methods
US9047746B1 (en) 2005-07-20 2015-06-02 Neil Euliano Electronic medication compliance monitoring system and associated methods
US8547248B2 (en) 2005-09-01 2013-10-01 Proteus Digital Health, Inc. Implantable zero-wire communications system
US8992511B2 (en) 2005-11-09 2015-03-31 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
US8083710B2 (en) 2006-03-09 2011-12-27 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
US7817030B2 (en) 2005-11-09 2010-10-19 Invention Science Fund 1, Llc Remote controller for in situ reaction device
US8936590B2 (en) 2005-11-09 2015-01-20 The Invention Science Fund I, Llc Acoustically controlled reaction device
US8273071B2 (en) 2006-01-18 2012-09-25 The Invention Science Fund I, Llc Remote controller for substance delivery system
US7942867B2 (en) 2005-11-09 2011-05-17 The Invention Science Fund I, Llc Remotely controlled substance delivery device
US8998886B2 (en) 2005-12-13 2015-04-07 The Invention Science Fund I, Llc Remote control of osmotic pump device
CN101340944B (en) * 2005-12-22 2013-04-03 皇家飞利浦电子股份有限公司 Device for controlled release of chemical molecules
WO2007074466A2 (en) 2005-12-28 2007-07-05 Starhome Gmbh Late forwarding to local voicemail system of calls to roaming users
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US20120035438A1 (en) 2006-04-12 2012-02-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Path selection by a lumen traveling device in a body tub tree based on previous path
US8936629B2 (en) 2006-04-12 2015-01-20 Invention Science Fund I Llc Autofluorescent imaging and target ablation
DE102006019419B4 (en) * 2006-04-26 2008-02-14 Siemens Ag Actuator, in particular an endo robot
JP2009544338A (en) 2006-05-02 2009-12-17 プロテウス バイオメディカル インコーポレイテッド Treatment regimen customized to the patient
US20070260174A1 (en) * 2006-05-05 2007-11-08 Searete Llc Detecting a failure to maintain a regimen
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
US8894974B2 (en) 2006-05-11 2014-11-25 Spectrum Dynamics Llc Radiopharmaceuticals for diagnosis and therapy
RU2009101475A (en) * 2006-06-20 2010-07-27 Конинклейке Филипс Электроникс, Н.В. (Nl) ELECTRONIC CAPSULE AND METHOD FOR TREATING A GASTROINTESTINAL DISEASE
WO2008012700A1 (en) 2006-06-23 2008-01-31 Koninklijke Philips Electronics, N.V. Medicament delivery system
US8172762B2 (en) * 2006-09-01 2012-05-08 Proteus Biomedical, Inc. Simultaneous blood flow and hematocrit sensor
US8588887B2 (en) * 2006-09-06 2013-11-19 Innurvation, Inc. Ingestible low power sensor device and system for communicating with same
US20080064938A1 (en) * 2006-09-08 2008-03-13 Semler John R Method of determining location of an ingested capsule
US9550050B2 (en) * 2006-09-25 2017-01-24 MEDIMETRICS Personalized Drug Delivery B.V. Medicament delivery apparatus
US8012744B2 (en) 2006-10-13 2011-09-06 Theranos, Inc. Reducing optical interference in a fluidic device
US8054140B2 (en) 2006-10-17 2011-11-08 Proteus Biomedical, Inc. Low voltage oscillator for medical devices
KR101611240B1 (en) 2006-10-25 2016-04-11 프로테우스 디지털 헬스, 인코포레이티드 Controlled activation ingestible identifier
EP2101643B1 (en) * 2006-10-31 2013-04-24 Medimetrics Personalized Drug Delivery B.V. Design of swallowable multi-nozzle, dosing device for releasing medicines in the gastrointestinal tract
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
WO2008063626A2 (en) 2006-11-20 2008-05-29 Proteus Biomedical, Inc. Active signal processing personal health signal receivers
WO2008062335A1 (en) * 2006-11-21 2008-05-29 Koninklijke Philips Electronics, N.V. Medicament delivery device, capsule and in vivo medicine delivery or diagnostic system
US8852172B2 (en) 2006-11-21 2014-10-07 Medimetrics Personalized Drug Delivery Ingestible electronic capsule and in vivo drug delivery or diagnostic system
US9275451B2 (en) 2006-12-20 2016-03-01 Biosensors International Group, Ltd. Method, a system, and an apparatus for using and processing multidimensional data
MY165532A (en) 2007-02-01 2018-04-02 Proteus Digital Health Inc Ingestible event marker systems
EP2111661B1 (en) 2007-02-14 2017-04-12 Proteus Digital Health, Inc. In-body power source having high surface area electrode
US8710957B2 (en) 2007-02-28 2014-04-29 Rf Surgical Systems, Inc. Method, apparatus and article for detection of transponder tagged objects, for example during surgery
EP2063771A1 (en) 2007-03-09 2009-06-03 Proteus Biomedical, Inc. In-body device having a deployable antenna
WO2008112577A1 (en) 2007-03-09 2008-09-18 Proteus Biomedical, Inc. In-body device having a multi-directional transmitter
US7696877B2 (en) 2007-05-01 2010-04-13 Rf Surgical Systems, Inc. Method, apparatus and article for detection of transponder tagged objects, for example during surgery
US20080287833A1 (en) * 2007-05-16 2008-11-20 Semler John R Method of evaluating gastroparesis using an ingestible capsule
US8540632B2 (en) 2007-05-24 2013-09-24 Proteus Digital Health, Inc. Low profile antenna for in body device
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
EP4011289A1 (en) 2007-09-25 2022-06-15 Otsuka Pharmaceutical Co., Ltd. In-body device with virtual dipole signal amplification
AU2008308686B2 (en) 2007-10-02 2015-01-22 Labrador Diagnostics Llc Modular point-of-care devices and uses thereof
US8789536B2 (en) * 2007-10-17 2014-07-29 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US8303573B2 (en) * 2007-10-17 2012-11-06 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US8707964B2 (en) * 2007-10-31 2014-04-29 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US20090105561A1 (en) * 2007-10-17 2009-04-23 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Medical or veterinary digestive tract utilization systems and methods
US8808276B2 (en) * 2007-10-23 2014-08-19 The Invention Science Fund I, Llc Adaptive dispensation in a digestive tract
US8521253B2 (en) 2007-10-29 2013-08-27 Spectrum Dynamics Llc Prostate imaging
US8333754B2 (en) * 2007-10-31 2012-12-18 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US8808271B2 (en) * 2007-10-31 2014-08-19 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US8109920B2 (en) * 2007-10-31 2012-02-07 The Invention Science Fund I, Llc Medical or veterinary digestive tract utilization systems and methods
US20090163894A1 (en) * 2007-10-31 2009-06-25 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Medical or veterinary digestive tract utilization systems and methods
US20090135886A1 (en) 2007-11-27 2009-05-28 Proteus Biomedical, Inc. Transbody communication systems employing communication channels
US20090137866A1 (en) * 2007-11-28 2009-05-28 Searete Llc, A Limited Liability Corporation Of The State Delaware Medical or veterinary digestive tract utilization systems and methods
US20090149839A1 (en) * 2007-12-11 2009-06-11 Hyde Roderick A Treatment techniques using ingestible device
JP6230772B2 (en) * 2008-02-18 2017-11-15 シュトコ・ツェーン・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング Administration of drugs to patients
JP2011513865A (en) 2008-03-05 2011-04-28 プロテウス バイオメディカル インコーポレイテッド Multi-mode communication ingestible event marker and system and method of using the same
WO2009151946A2 (en) 2008-05-27 2009-12-17 Rf Surgical Systems, Inc. Multi-modal transponder and method and apparatus to detect same
US8111162B2 (en) * 2008-05-28 2012-02-07 Rf Surgical Systems, Inc. Method, apparatus and article for detection of transponder tagged objects, for example during surgery
JP5500600B2 (en) * 2008-06-19 2014-05-21 コーニンクレッカ フィリップス エヌ ヴェ Device for the delivery of powdered drugs in moist environments
WO2010004490A2 (en) * 2008-07-07 2010-01-14 Koninklijke Philips Electronics N.V. Electronic pill comprising a medicine reservoir
WO2010005877A2 (en) 2008-07-08 2010-01-14 Proteus Biomedical, Inc. Ingestible event marker data framework
US8423122B2 (en) * 2008-07-10 2013-04-16 Given Imaging Ltd. Localization of capsule with a synthetic source of quadrupoles and dipoles
KR101214453B1 (en) 2008-08-13 2012-12-24 프로테우스 디지털 헬스, 인코포레이티드 Ingestible circuitry
DE102008044994A1 (en) 2008-08-29 2010-03-04 Hochschule Offenburg Electronic pill for the controllable delivery of a substance, in particular a medicament, in a human or animal body
US8726911B2 (en) 2008-10-28 2014-05-20 Rf Surgical Systems, Inc. Wirelessly detectable objects for use in medical procedures and methods of making same
US8264342B2 (en) 2008-10-28 2012-09-11 RF Surgical Systems, Inc Method and apparatus to detect transponder tagged objects, for example during medical procedures
KR101192690B1 (en) 2008-11-13 2012-10-19 프로테우스 디지털 헬스, 인코포레이티드 Ingestible therapy activator system, therapeutic device and method
SG172077A1 (en) 2008-12-11 2011-07-28 Proteus Biomedical Inc Evaluation of gastrointestinal function using portable electroviscerography systems and methods of using the same
US9439566B2 (en) 2008-12-15 2016-09-13 Proteus Digital Health, Inc. Re-wearable wireless device
TWI503101B (en) 2008-12-15 2015-10-11 Proteus Digital Health Inc Body-associated receiver and method
WO2013012869A1 (en) 2011-07-21 2013-01-24 Proteus Digital Health, Inc. Mobile communication device, system, and method
US9659423B2 (en) 2008-12-15 2017-05-23 Proteus Digital Health, Inc. Personal authentication apparatus system and method
CN102341031A (en) 2009-01-06 2012-02-01 普罗秋斯生物医学公司 Ingestion-related biofeedback and personalized medical therapy method and system
EP3395333A1 (en) 2009-01-06 2018-10-31 Proteus Digital Health, Inc. Pharmaceutical dosages delivery system
GB2480965B (en) 2009-03-25 2014-10-08 Proteus Digital Health Inc Probablistic pharmacokinetic and pharmacodynamic modeling
AU2010235197B2 (en) * 2009-03-31 2014-10-16 Covidien Lp Method of determining body exit of an ingested capsule
BRPI1006765A2 (en) 2009-04-07 2019-03-26 Koninl Philips Electronics Nv ingestible capsule for drug release
DE102009017662B4 (en) 2009-04-16 2016-11-10 Hochschule Offenburg Electronic pill for the controllable delivery of a substance, in particular a medicament, in a human or animal body
MX2011011506A (en) * 2009-04-28 2012-05-08 Proteus Biomedical Inc Highly reliable ingestible event markers and methods for using the same.
US20100286587A1 (en) * 2009-05-07 2010-11-11 Yossi Gross Sublingual electrical drug delivery
US8414559B2 (en) 2009-05-07 2013-04-09 Rainbow Medical Ltd. Gastroretentive duodenal pill
US9149423B2 (en) 2009-05-12 2015-10-06 Proteus Digital Health, Inc. Ingestible event markers comprising an ingestible component
US9457150B2 (en) * 2009-06-01 2016-10-04 Sanofi-Aventis Deutschland Gmbh Biasing mechanism for a drug delivery device
DE102009024949B3 (en) 2009-06-11 2011-02-24 Andrä, Wilfried, Prof. Dr. Remote drug delivery assembly
US8338788B2 (en) 2009-07-29 2012-12-25 Spectrum Dynamics Llc Method and system of optimized volumetric imaging
US8682440B2 (en) 2009-08-03 2014-03-25 Incube Labs, Llc Swallowable capsule and method for stimulating incretin production within the intestinal tract
US10046109B2 (en) 2009-08-12 2018-08-14 Progenity, Inc. Drug delivery device with compressible drug reservoir
US8558563B2 (en) 2009-08-21 2013-10-15 Proteus Digital Health, Inc. Apparatus and method for measuring biochemical parameters
BR112012009196B1 (en) 2009-10-19 2021-03-30 Labrador Diagnostics Llc SYSTEM FOR MODELING THE PROGRESSION OF A DISEASE WITHIN A POPULATION
TWI517050B (en) 2009-11-04 2016-01-11 普羅托斯數位健康公司 System for supply chain management
US9226686B2 (en) 2009-11-23 2016-01-05 Rf Surgical Systems, Inc. Method and apparatus to account for transponder tagged objects used during medical procedures
UA109424C2 (en) 2009-12-02 2015-08-25 PHARMACEUTICAL PRODUCT, PHARMACEUTICAL TABLE WITH ELECTRONIC MARKER AND METHOD OF MANUFACTURING PHARMACEUTICAL TABLETS
US8562589B2 (en) 2009-12-24 2013-10-22 Rani Therapeutics, Llc Swallowable drug delivery device and method of delivery
AU2011210648B2 (en) 2010-02-01 2014-10-16 Otsuka Pharmaceutical Co., Ltd. Data gathering system
WO2011127252A2 (en) 2010-04-07 2011-10-13 Proteus Biomedical, Inc. Miniature ingestible device
EP2377574A3 (en) * 2010-04-13 2011-11-30 BIOTRONIK SE & Co. KG Implant and applicator
TWI557672B (en) 2010-05-19 2016-11-11 波提亞斯數位康健公司 Computer system and computer-implemented method to track medication from manufacturer to a patient, apparatus and method for confirming delivery of medication to a patient, patient interface device
EP2642983A4 (en) 2010-11-22 2014-03-12 Proteus Digital Health Inc Ingestible device with pharmaceutical product
US10639272B2 (en) 2010-12-23 2020-05-05 Rani Therapeutics, Llc Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device
US8809271B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising liraglutide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9629799B2 (en) 2010-12-23 2017-04-25 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402806B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9415004B2 (en) 2010-12-23 2016-08-16 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9149617B2 (en) 2010-12-23 2015-10-06 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US9283179B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9259386B2 (en) 2010-12-23 2016-02-16 Rani Therapeutics, Llc Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8969293B2 (en) 2010-12-23 2015-03-03 Rani Therapeutics, Llc Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8846040B2 (en) 2010-12-23 2014-09-30 Rani Therapeutics, Llc Therapeutic agent preparations comprising etanercept for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8980822B2 (en) 2010-12-23 2015-03-17 Rani Therapeutics, Llc Therapeutic agent preparations comprising pramlintide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9861683B2 (en) 2010-12-23 2018-01-09 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8764733B2 (en) 2010-12-23 2014-07-01 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8734429B2 (en) 2010-12-23 2014-05-27 Rani Therapeutics, Llc Device, system and methods for the oral delivery of therapeutic compounds
US9284367B2 (en) 2010-12-23 2016-03-15 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US8809269B2 (en) 2010-12-23 2014-08-19 Rani Therapeutics, Llc Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
US9402807B2 (en) 2010-12-23 2016-08-02 Rani Therapeutics, Llc Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
AR085087A1 (en) 2011-01-21 2013-09-11 Theranos Inc SYSTEMS AND METHODS TO MAXIMIZE THE USE OF SAMPLES
US9439599B2 (en) 2011-03-11 2016-09-13 Proteus Digital Health, Inc. Wearable personal body associated device with various physical configurations
WO2012170068A2 (en) 2011-06-05 2012-12-13 University Of British Columbia Wireless microactuators and control methods
WO2015112603A1 (en) 2014-01-21 2015-07-30 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
US9756874B2 (en) 2011-07-11 2017-09-12 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
US8514067B2 (en) 2011-08-16 2013-08-20 Elwha Llc Systematic distillation of status data relating to regimen compliance
ITFI20110185A1 (en) 2011-08-23 2013-02-24 Fond Istituto Italiano Di Tecnologia CAPSULE FOR LOCALIZED THERAPY THROUGH ENDOLUMINAL PATCHES IN THE GASTROINTESTINAL SYSTEM
JP5916031B2 (en) * 2011-09-05 2016-05-11 株式会社ミュー Medical equipment
US9235683B2 (en) 2011-11-09 2016-01-12 Proteus Digital Health, Inc. Apparatus, system, and method for managing adherence to a regimen
EP3725234A1 (en) 2012-02-17 2020-10-21 Progenity, Inc. Ingestible medical device
WO2013126178A1 (en) * 2012-02-24 2013-08-29 Capso Vision Inc Power source control for medical capsules
US10264972B2 (en) * 2012-05-21 2019-04-23 International Business Machines Corporation Dispensing drugs from a companion diagnostic linked smart pill
TW201424689A (en) 2012-07-23 2014-07-01 Proteus Digital Health Inc Techniques for manufacturing ingestible event markers comprising an ingestible component
WO2014053352A1 (en) 2012-10-03 2014-04-10 Danmarks Tekniske Universitet Ingestible capsule for remote controlled release of a substance
US9268909B2 (en) 2012-10-18 2016-02-23 Proteus Digital Health, Inc. Apparatus, system, and method to adaptively optimize power dissipation and broadcast power in a power source for a communication device
US11149123B2 (en) 2013-01-29 2021-10-19 Otsuka Pharmaceutical Co., Ltd. Highly-swellable polymeric films and compositions comprising the same
JP6498177B2 (en) 2013-03-15 2019-04-10 プロテウス デジタル ヘルス， インコーポレイテッド Identity authentication system and method
JP6796484B2 (en) * 2013-03-15 2020-12-09 ラニ セラピューティクス， エルエルシー Device for oral delivery of therapeutic compounds
GB201304738D0 (en) * 2013-03-15 2013-05-01 Mars Inc Sampling Device
US10175376B2 (en) 2013-03-15 2019-01-08 Proteus Digital Health, Inc. Metal detector apparatus, system, and method
JP6511439B2 (en) 2013-06-04 2019-05-15 プロテウス デジタル ヘルス， インコーポレイテッド Systems, devices, and methods for data collection and outcome assessment
US9796576B2 (en) 2013-08-30 2017-10-24 Proteus Digital Health, Inc. Container with electronically controlled interlock
MX356850B (en) 2013-09-20 2018-06-15 Proteus Digital Health Inc Methods, devices and systems for receiving and decoding a signal in the presence of noise using slices and warping.
US9577864B2 (en) 2013-09-24 2017-02-21 Proteus Digital Health, Inc. Method and apparatus for use with received electromagnetic signal at a frequency not known exactly in advance
US10084880B2 (en) 2013-11-04 2018-09-25 Proteus Digital Health, Inc. Social media networking based on physiologic information
US10521561B1 (en) 2013-12-17 2019-12-31 Etectrx, Inc. Electronic compliance system and associated methods
US9514341B2 (en) 2014-03-31 2016-12-06 Covidien Lp Method, apparatus and article for detection of transponder tagged objects, for example during surgery
WO2015152975A1 (en) 2014-03-31 2015-10-08 Rf Surgical Systems, Inc. Hand-held spherical antenna system to detect transponder tagged objects, for example during surgery
EP3151906B1 (en) 2014-06-03 2019-12-11 Pop Test Abuse Deterrent Technology LLC Drug device configured for wireless communication
US11419586B2 (en) 2014-09-17 2022-08-23 Mars, Incorporated Sampling device with ejectable compartment
CN107106148B (en) 2014-09-17 2020-09-11 马斯公司 Sampling device and method for obtaining a sample in the gastrointestinal tract of an animal
EP3197336B1 (en) 2014-09-25 2020-12-23 Progenity, Inc. Electromechanical pill device with localization capabilities
DE102014116537A1 (en) * 2014-11-12 2016-05-12 Infineon Technologies Ag Functional skin patch
US10912515B2 (en) * 2014-11-19 2021-02-09 Veloce Corporation Wireless communications system integrating electronics into orally ingestible products for controlled release of active ingredients
US9750923B2 (en) 2014-11-19 2017-09-05 Velóce Corporation Wireless communications system integrating electronics into orally ingestible products for controlled release of active ingredients
US10660726B2 (en) 2015-01-21 2020-05-26 Covidien Lp Sterilizable wirelessly detectable objects for use in medical procedures and methods of making same
CN107205793B (en) 2015-01-21 2021-09-14 柯惠Lp公司 Detectable sponge for use in medical procedures and methods of making, packaging and accounting thereof
AU2016200113B2 (en) 2015-01-21 2019-10-31 Covidien Lp Wirelessly detectable objects for use in medical procedures and methods of making same
AU2016200928B2 (en) 2015-02-26 2020-11-12 Covidien Lp Apparatuses to physically couple transponder to objects, such as surgical objects, and methods of using same
US9690963B2 (en) 2015-03-02 2017-06-27 Covidien Lp Hand-held dual spherical antenna system
USD775331S1 (en) 2015-03-02 2016-12-27 Covidien Lp Hand-held antenna system
US10193209B2 (en) 2015-04-06 2019-01-29 Covidien Lp Mat based antenna and heater system, for use during medical procedures
US11051543B2 (en) 2015-07-21 2021-07-06 Otsuka Pharmaceutical Co. Ltd. Alginate on adhesive bilayer laminate film
AU2016365123B2 (en) * 2015-11-30 2020-11-19 Jvd, Inc. Medicine delivery and animal management systems
CN109843149B (en) 2016-07-22 2020-07-07 普罗秋斯数字健康公司 Electromagnetic sensing and detection of ingestible event markers
JP2019526423A (en) * 2016-09-09 2019-09-19 ミッチェル・ローレンス・ジョーンズＭｉｔｃｈｅｌｌ Ｌａｗｒｅｎｃｅ ＪＯＮＥＳ Electromechanically ingestible device for delivery of dispenseable substances
GB2554354B (en) 2016-09-21 2021-06-02 Vibrant Ltd Systems for adaptive treatment of disorders in the gastrointestinal tract
JP2019535377A (en) 2016-10-26 2019-12-12 プロテウス デジタル ヘルス， インコーポレイテッド Method for producing capsules with ingestible event markers
WO2018106931A1 (en) 2016-12-07 2018-06-14 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
WO2018111329A1 (en) * 2016-12-14 2018-06-21 Progenity Inc. Methods and ingestible devices for the regio-specific release of il-1 inhibitors at the site of gastrointestinal tract disease
WO2018111323A1 (en) * 2016-12-14 2018-06-21 Progenity Inc. Methods and ingestible devices for the regio-specific release of smad7 inhibitors at the site of gastrointestinal tract disease
WO2018111328A1 (en) * 2016-12-14 2018-06-21 Progenity Inc. Methods and ingestible devices for the regio-specific release of tnf inhibitors at the site of gastrointestinal tract disease
JP2020513280A (en) 2016-12-14 2020-05-14 プロジェニティ， インコーポレイテッド Treatment of digestive tract diseases with immunosuppressants
KR20190097107A (en) * 2016-12-14 2019-08-20 프로제너티, 인크. Treatment and apparatus of gastrointestinal diseases with JAK inhibitors
CA3046019A1 (en) 2016-12-14 2018-06-21 Progenity Inc. Treatment of a disease of the gastrointestinal tract with a tlr modulator
WO2018111322A1 (en) * 2016-12-14 2018-06-21 Progenity Inc. Methods and ingestible devices for the regio-specific release of integrin inhibitors at the site of gastrointestinal tract disease
WO2018111325A1 (en) * 2016-12-14 2018-06-21 Progenity Inc. Methods and ingestible devices for the regio-specific release of il-6r inhibitors at the site of gastrointestinal tract disease
WO2018111321A1 (en) * 2016-12-14 2018-06-21 Progenity Inc. Methods and ingestible devices for the regio-specific release of il-12/il-23 inhibitors at the site of gastrointestinal tract disease
CN110072551B (en) 2016-12-14 2023-05-23 比奥拉治疗股份有限公司 Treatment of gastrointestinal disorders using IL-12/IL-23 inhibitors released using ingestible devices
US11134889B2 (en) 2016-12-14 2021-10-05 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a SMAD7 inhibitor
WO2018111327A1 (en) * 2016-12-14 2018-06-21 Progenity Inc. Methods and ingestible devices for the regio-specific release of jak inhibitors at the site of gastrointestinal tract disease
WO2018111324A1 (en) * 2016-12-14 2018-06-21 Progenity Inc. Methods and ingestible devices for the regio-specific release of tlr agonists at the site of gastrointestinal tract disease
CN106823113A (en) * 2017-01-24 2017-06-13 武汉市瑞达源科技有限公司 A kind of medical capsule device
US10888277B1 (en) 2017-01-30 2021-01-12 Vibrant Ltd Method for treating diarrhea and reducing Bristol stool scores using a vibrating ingestible capsule
US10905378B1 (en) 2017-01-30 2021-02-02 Vibrant Ltd Method for treating gastroparesis using a vibrating ingestible capsule
WO2018182641A1 (en) * 2017-03-30 2018-10-04 Progenity Inc. Methods and ingestible devices for the regio-specific release of il-13 inhibitors at the site of gastrointestinal tract disease
WO2018182612A1 (en) * 2017-03-30 2018-10-04 Progenity Inc. Methods and ingestible devices for the regio-specific release of stem cells at the site of gastrointestinal tract disease
WO2018182623A1 (en) * 2017-03-30 2018-10-04 Progenity Inc. Methods and ingestible devices for the regio-specific release of chst15 inhibitors at the site of gastrointestinal tract disease
CA3055762A1 (en) 2017-03-31 2018-10-04 Progenity, Inc. Localization systems and methods for an ingestible device
CN110636881B (en) 2017-05-17 2023-09-01 美敦力公司 Antenna for implantable medical device
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
IL301683A (en) 2017-05-17 2023-05-01 Massachusetts Inst Technology Self-righting systems and related components and methods
US11439747B2 (en) * 2017-10-04 2022-09-13 Purdue Research Foundation Drug delivery device and method
EP3765138A1 (en) 2018-03-13 2021-01-20 Progenity, Inc. Ingestible device with relatively large payload volume
US11504024B2 (en) 2018-03-30 2022-11-22 Vibrant Ltd. Gastrointestinal treatment system including a vibrating capsule, and method of use thereof
US10537720B2 (en) 2018-04-09 2020-01-21 Vibrant Ltd. Method of enhancing absorption of ingested medicaments for treatment of parkinsonism
US11638678B1 (en) 2018-04-09 2023-05-02 Vibrant Ltd. Vibrating capsule system and treatment method
US11020576B2 (en) 2018-04-11 2021-06-01 Jvd, Inc. Medicine delivery and animal management systems
US11510590B1 (en) 2018-05-07 2022-11-29 Vibrant Ltd. Methods and systems for treating gastrointestinal disorders
WO2019222570A1 (en) 2018-05-17 2019-11-21 Massachusetts Institute Of Technology Systems for electrical stimulation
US10675248B2 (en) 2018-08-14 2020-06-09 Alma Therapeutics Ltd. Expandable pill
EP3883635A1 (en) 2018-11-19 2021-09-29 Progenity, Inc. Methods and devices for treating a disease with biotherapeutics
JP7311917B2 (en) 2019-01-03 2023-07-20 ヴァイブラント リミテッド A device for delivering an ingestible agent into a user's gastrointestinal tract
US11786142B2 (en) * 2019-01-11 2023-10-17 Tokitae Llc Ingestible RFID tag and reader system
GB201900780D0 (en) 2019-01-21 2019-03-06 Vibrant Ltd Device and method for delivering a flowable ingestible medicament into the gastrointestinal tract of a user
WO2020160399A1 (en) 2019-02-01 2020-08-06 Massachusetts Institute Of Technology Systems and methods for liquid injection
GB201901470D0 (en) 2019-02-04 2019-03-27 Vibrant Ltd Vibrating capsule for gastrointestinal treatment, and method of use thereof
KR102225352B1 (en) * 2019-02-19 2021-03-09 주식회사 인트로메딕 Capsule endoscopy
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components
US11707610B2 (en) 2019-12-13 2023-07-25 Biora Therapeutics, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
US11620464B2 (en) 2020-03-31 2023-04-04 Covidien Lp In-vivo introducible antenna for detection of RF tags
WO2023154257A1 (en) * 2022-02-08 2023-08-17 Trustees Of Tufts College Ingestible capsule with beads for sampling content of the gastrointestinal tract

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH337989A (en) * 1957-04-09 1959-04-30 Perrenoud Jean Pierre Dr Capsule
US3485235A (en) * 1967-12-04 1969-12-23 Ronald Felson Capsule for the study and treatment of the digestive tract
US3659600A (en) * 1970-02-24 1972-05-02 Estin Hans H Magnetically operated capsule for administering drugs
US4239040A (en) * 1976-10-19 1980-12-16 Kabushiki Kaisha Daini Seikosha Capsule for medical use
DE2928477C3 (en) * 1979-07-14 1982-04-15 Battelle-Institut E.V., 6000 Frankfurt Device for the release of substances at defined locations in the digestive tract
JPS57156736A (en) * 1981-03-23 1982-09-28 Olympus Optical Co Therapeutic capsule apparatus
JPS57163309A (en) * 1981-04-01 1982-10-07 Olympus Optical Co Ltd Capsule apparatus for medical use
JPS58121938A (en) * 1982-01-14 1983-07-20 舟久保　煕康 Sampling capsule
DE3339323C2 (en) * 1983-10-29 1986-01-30 Busch, Ulrich, 2000 Hamburg Transport capsule for pipeline systems
DE3737104A1 (en) 1987-11-02 1989-05-11 Altenkirchener Kunststoff HOSE PIECE OF ELASTIC, EASILY RESETTABLE PLASTIC AND METHOD FOR THE PRODUCTION THEREOF
DE3820795A1 (en) * 1988-06-20 1989-12-21 Ingun Pruefmittelbau Gmbh SPRING CONTACT PIN FOR TESTING DUTES
US4844076A (en) * 1988-08-26 1989-07-04 The Johns Hopkins University Ingestible size continuously transmitting temperature monitoring pill
EP0460327B1 (en) 1990-07-06 1994-05-18 Miyarisan Kabushiki Kaisha Medical capsule and apparatus for activating the same
US5170801A (en) * 1990-10-02 1992-12-15 Glaxo Inc. Medical capsule device actuated by radio-frequency (rf) signal
US5167626A (en) * 1990-10-02 1992-12-01 Glaxo Inc. Medical capsule device actuated by radio-frequency (RF) signal
US5196002A (en) * 1990-10-09 1993-03-23 University Of Utah Research Foundation Implantable drug delivery system with piston acutation
DE4037043A1 (en) * 1990-11-19 1992-05-21 Ulrich Dr Med Hanack Bimetallic energy converter implantable in living tissue - uses HF EM field to enable reversible compression of internal vessels, e.g. blood or lymph vessels
US5217449A (en) * 1990-12-11 1993-06-08 Miyarisan Kabushiki Kaisha Medical capsule and apparatus for activating the same
AU650113B2 (en) 1991-04-05 1994-06-09 Eli Lilly And Company Sustained release capsule and formulations
US5279607A (en) 1991-05-30 1994-01-18 The State University Of New York Telemetry capsule and process
US5639074A (en) * 1996-03-05 1997-06-17 Smalley Steel Ring Co. Interlaced wave spring
US5951594A (en) * 1998-04-28 1999-09-14 Vitatron Medical B.V. Air core antenna for implantable device and method of production
GB9930000D0 (en) * 1999-12-21 2000-02-09 Phaeton Research Ltd An ingestible device

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006047882A1 (en) * 2004-11-05 2006-05-11 Electronic Dietary Foods Inc. Controlled degradation of expandable polymers in gastric volume reduction treatment
US8691269B2 (en) 2004-11-05 2014-04-08 Martin Pavlov Mintchev Controlled degradation of expandable polymers in gastric volume reduction treatment

Also Published As

Publication number Publication date
US7763014B2 (en) 2010-07-27
EP2016898A2 (en) 2009-01-21
AU2198201A (en) 2001-07-03
EP2016898A3 (en) 2009-04-08
DE60041666D1 (en) 2009-04-09
DK2016898T3 (en) 2010-10-25
WO2001045789A2 (en) 2001-06-28
EP1398052A3 (en) 2006-06-07
EP2016898B1 (en) 2010-07-07
US7282045B2 (en) 2007-10-16
EP1398052B1 (en) 2009-02-25
DE60044656D1 (en) 2010-08-19
DK1398052T3 (en) 2009-06-15
US6632216B2 (en) 2003-10-14
EP1398052A2 (en) 2004-03-17
JP2003517902A (en) 2003-06-03
US20070270630A1 (en) 2007-11-22
GB9930000D0 (en) 2000-02-09
WO2001045789A3 (en) 2001-11-08
ATE423506T1 (en) 2009-03-15
US20050075559A1 (en) 2005-04-07
EP1239769A2 (en) 2002-09-18
ATE472970T1 (en) 2010-07-15
CA2390032C (en) 2011-08-23
US20020055734A1 (en) 2002-05-09

Similar Documents

Publication Publication Date Title
CA2390032A1 (en) Ingestible device for the release of substances at distinct locations in the alimentary canal
US4065753A (en) Electromagnetically responsive projectile and system for detecting same
RU2219569C2 (en) Method and screening device with use of lateral slots
US4087791A (en) Electromagnetically responsive device and system for detecting the same
CA2234067C (en) Pulsed-signal magnetomechanical electronic article surveillance system with improved damping of transmitting antenna
US2958781A (en) Radio-physiological method and means
ATE4958T1 (en) SWALLOWABLE CAPSULE FOR RELEASING SUBSTANCES AT SPECIFIED LOCATIONS OF THE DIGESTIVE TRACT.
JPH09502549A (en) Passive tag identification system and method
AU720009B2 (en) Retractable antenna system
CN100588378C (en) Alimentary tract drug release remote controlled capsule system
TW333717B (en) Portable device for receiving and/or transmitting radio-transmitted message
PT1356545E (en) INTERSTICAL ANTENNA OF MICROWAVES WITH A MINIATURIZED STROKE FOR HYPERTHERMIA IN MEDICINE AND SURGERY
US20090256447A1 (en) Ferroelectric energy generator, system, and method
EP1038504A4 (en) Disposable medical instrument and medical device incorporating the instrument
US9895116B2 (en) Linear fail safe radiation concealment mechanism
RU2448360C1 (en) Electromechanical device for protection of information placed on digital media against unauthorised access
MY116731A (en) Antenna apparatus.
EP1481705B1 (en) A radiofrequency-controlled device for release / sampling of substances
NO20011439L (en) Electrostatic reinforcing device for an explosive projectile
CA2295394A1 (en) Microwave oven
WO1988004523A1 (en) Stock handling device
WO2014053352A1 (en) Ingestible capsule for remote controlled release of a substance
JPS6321494B2 (en)
WO2019025463A1 (en) High-speed magnetic synchronization of wireless detector
UA96517C2 (en) Information protection device located on digital usb flash drive from unathorized access

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20151214