CA2393258A1 - Phenothiazines in prill form - Google Patents

Phenothiazines in prill form Download PDF

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Publication number
CA2393258A1
CA2393258A1 CA002393258A CA2393258A CA2393258A1 CA 2393258 A1 CA2393258 A1 CA 2393258A1 CA 002393258 A CA002393258 A CA 002393258A CA 2393258 A CA2393258 A CA 2393258A CA 2393258 A1 CA2393258 A1 CA 2393258A1
Authority
CA
Canada
Prior art keywords
phenothiazine
fines
phenothiazines
spherical shape
generally spherical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002393258A
Other languages
French (fr)
Other versions
CA2393258C (en
Inventor
David Alan Vanzin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytec Technology Corp
Original Assignee
Avecia Inc.
David Alan Vanzin
Cytec Technology Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avecia Inc., David Alan Vanzin, Cytec Technology Corp. filed Critical Avecia Inc.
Publication of CA2393258A1 publication Critical patent/CA2393258A1/en
Application granted granted Critical
Publication of CA2393258C publication Critical patent/CA2393258C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
    • C09K15/04—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
    • C09K15/30—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing heterocyclic ring with at least one nitrogen atom as ring member

Abstract

The invention relates to (a) phenothiazine or a phenothiazine analog or derivative (phenothiazine material) in the form of prills of a generally spherical shape containing very low levels of fines and also (b) a method of forming a phenothiazine material in prill form having a generally spherical shape. The prilled phenothiazine material exhibits improved handling, flowability and dissolation times, while minimizing the generation of fines, and the problems of irritation and sensitization through exposure to such fines.
CA002393258A 1999-12-03 2000-12-01 Phenothiazines in prill form Expired - Lifetime CA2393258C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/453685 1999-12-03
US09/453,685 US6284279B1 (en) 1999-12-03 1999-12-03 Phenothiazine in prill form and method for making the same
PCT/GB2000/004600 WO2001040209A1 (en) 1999-12-03 2000-12-01 Phenothiazines in prill form

Publications (2)

Publication Number Publication Date
CA2393258A1 true CA2393258A1 (en) 2001-06-07
CA2393258C CA2393258C (en) 2008-04-08

Family

ID=23801641

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002393258A Expired - Lifetime CA2393258C (en) 1999-12-03 2000-12-01 Phenothiazines in prill form

Country Status (21)

Country Link
US (2) US6284279B1 (en)
EP (1) EP1250329B1 (en)
JP (5) JP2003515598A (en)
KR (1) KR100829152B1 (en)
CN (1) CN100345832C (en)
AT (1) ATE457024T1 (en)
AU (1) AU1540401A (en)
BR (1) BR0016139B1 (en)
CA (1) CA2393258C (en)
CY (1) CY1110614T1 (en)
CZ (1) CZ301159B6 (en)
DE (3) DE60043797D1 (en)
DK (1) DK1250329T3 (en)
ES (1) ES2338984T3 (en)
HU (1) HU228334B1 (en)
IN (1) IN2005MU01159A (en)
MX (1) MX227869B (en)
PT (1) PT1250329E (en)
RU (1) RU2261247C2 (en)
WO (1) WO2001040209A1 (en)
ZA (1) ZA200204400B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284279B1 (en) * 1999-12-03 2001-09-04 Avecia, Inc. Phenothiazine in prill form and method for making the same
DE10032137B4 (en) * 2000-07-01 2009-04-02 Allessachemie Gmbh Process for the preparation of phenothiazine granules with improved properties
US7413690B1 (en) 2003-10-29 2008-08-19 The University Of Mississippi Process and apparatus for producing spherical pellets using molten solid matrices
JP2008188477A (en) * 2005-06-23 2008-08-21 Seiko Kagaku Kk Method for manufacturing particulate chemical substance
US7638076B2 (en) * 2007-10-26 2009-12-29 Martin Resource Management Corporation Method and system for pelletizing sulfur
CN101234315B (en) * 2008-03-10 2013-01-09 泰兴市富安化工有限公司 Hollow granular thiophenylamine substance and preparation thereof
US8329072B2 (en) 2010-11-24 2012-12-11 Brimrock International Inc. Method and system for generating sulfur seeds and granules
KR101400393B1 (en) * 2012-08-28 2014-05-27 주식회사 이루켐 Liquid granulating apparatus
US10933390B2 (en) * 2017-12-13 2021-03-02 Wisys Technology Foundation, Inc. Microparticle generation system

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2781318A (en) * 1952-03-28 1957-02-12 Exxon Research Engineering Co Mineral lubricating oil additive
DE1003137B (en) * 1953-01-26 1957-02-21 Hugo Hettich Fork lock for watches with free anchor passage
US3169868A (en) 1962-04-16 1965-02-16 Eastman Kodak Co Light sensitive photoresist composition
US3607993A (en) 1969-05-20 1971-09-21 Malcolm H Tuttle Method of prilling
US3912727A (en) 1972-11-22 1975-10-14 Grace W R & Co Preparation of phenothiazines
NL7401406A (en) * 1974-02-01 1975-08-05 Stamicarbon METHOD AND DEVICE FOR PREPARING S.
GB1493612A (en) 1974-07-06 1977-11-30 Fisons Ltd Prilling
US4021552A (en) 1975-06-27 1977-05-03 A. H. Robins Company, Incorporated 10-[ω-(BENZOYLPIPERIDINYL)ALKYL]PHENOTHIAZINES
DE3127750A1 (en) * 1981-07-14 1983-02-03 Bayer Ag, 5090 Leverkusen REACTIVE COMPONENTS CONTAINING STABILIZERS FOR PU FOAMS, NEW STABILIZERS AND A METHOD FOR THE PRODUCTION OF THE STABILIZERS
US4785095A (en) 1986-09-16 1988-11-15 The Lubrizol Corporation N-substituted thio alkyl phenothiazines
DE3701330A1 (en) 1987-01-19 1988-07-28 Bayerische Motoren Werke Ag PISTON WITH BALLY EXTERIOR
US4935173A (en) * 1987-01-20 1990-06-19 The Dow Chemical Company Process for producing prills
US4793783A (en) 1987-01-20 1988-12-27 The Dow Chemical Company Apparatus for producing prills
DE3701738A1 (en) 1987-01-22 1988-08-04 Bayer Ag NEW STABILIZERS AND THEIR USE FOR THE PRODUCTION OF STABILIZED POLYAMIDES AND RUBBER MATERIALS
US5024774A (en) 1987-06-09 1991-06-18 The Lubrizol Corporation Nitrogen containing anti-oxidant compositions
US5006284A (en) 1989-06-14 1991-04-09 Ciba-Geigy Corporation Granules of alkyl esters containing hydroxyphenyl groups
FR2652084B1 (en) 1989-09-21 1991-10-31 Rhone Poulenc Sante NOVEL PHENOTHIAZINE DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
DE4022648C2 (en) * 1990-07-17 1994-01-27 Nukem Gmbh Method and device for producing spherical particles from a liquid phase
IT1244742B (en) 1991-02-14 1994-08-08 Zambon Spa PROCESS FOR DIRECT AND REGIO-SELECTIVE FUNCTIONALIZATION IN POSITION 2 OF PHENOTHIAZINE
US5352871A (en) 1991-02-20 1994-10-04 Metcal Inc System and method for joining plastic materials
NL9400618A (en) 1994-04-18 1995-12-01 Goudsche Machinefabriek Bv Device for cooling and processing a molten product into a granulate product.
US5451337A (en) * 1994-05-31 1995-09-19 The Procter & Gamble Co. Dye transfer inhibition system containing a peroxidase/accelerator system
US5763449A (en) * 1996-08-07 1998-06-09 Ascent Pediatrics, Inc. Pleasant-tasting aqueous liquid composition of a bitter-tasting drug
EP1264822A3 (en) 1997-04-15 2003-01-29 Ciba SC Holding AG Stabiliser modification
NL1007904C2 (en) 1997-12-24 1999-06-25 Goudsche Machinefabriek Bv Method and device for forming granulate from a melt of chemical products.
US6284279B1 (en) * 1999-12-03 2001-09-04 Avecia, Inc. Phenothiazine in prill form and method for making the same
DE10032137B4 (en) 2000-07-01 2009-04-02 Allessachemie Gmbh Process for the preparation of phenothiazine granules with improved properties

Also Published As

Publication number Publication date
IN2005MU01159A (en) 2006-05-05
JP5134243B2 (en) 2013-01-30
AU1540401A (en) 2001-06-12
US6485750B2 (en) 2002-11-26
JP2007191712A (en) 2007-08-02
KR20020058075A (en) 2002-07-12
CZ20021888A3 (en) 2002-09-11
JP2012232992A (en) 2012-11-29
PT1250329E (en) 2010-03-11
KR100829152B1 (en) 2008-05-13
ZA200204400B (en) 2003-11-26
US6284279B1 (en) 2001-09-04
CA2393258C (en) 2008-04-08
CN1433409A (en) 2003-07-30
RU2261247C2 (en) 2005-09-27
JP2013040188A (en) 2013-02-28
DE00977769T1 (en) 2007-01-18
JP2003515598A (en) 2003-05-07
BR0016139A (en) 2002-08-06
HUP0204078A2 (en) 2003-05-28
DE60043797D1 (en) 2010-03-25
MX227869B (en) 2005-05-17
JP2010222360A (en) 2010-10-07
MXPA02005474A (en) 2004-03-26
HU228334B1 (en) 2013-03-28
DK1250329T3 (en) 2010-05-25
CY1110614T1 (en) 2015-06-10
WO2001040209A1 (en) 2001-06-07
EP1250329A1 (en) 2002-10-23
ES2338984T3 (en) 2010-05-14
DE20023878U1 (en) 2006-12-28
CN100345832C (en) 2007-10-31
CZ301159B6 (en) 2009-11-18
BR0016139B1 (en) 2012-09-04
ATE457024T1 (en) 2010-02-15
US20020102310A1 (en) 2002-08-01
EP1250329B1 (en) 2010-02-03
JP5080610B2 (en) 2012-11-21

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20201201