CA2399279A1 - Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use - Google Patents
Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use Download PDFInfo
- Publication number
- CA2399279A1 CA2399279A1 CA002399279A CA2399279A CA2399279A1 CA 2399279 A1 CA2399279 A1 CA 2399279A1 CA 002399279 A CA002399279 A CA 002399279A CA 2399279 A CA2399279 A CA 2399279A CA 2399279 A1 CA2399279 A1 CA 2399279A1
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- Prior art keywords
- active material
- particles
- controlled release
- ceramic particles
- precursor
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5115—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B33/00—Silicon; Compounds thereof
- C01B33/113—Silicon oxides; Hydrates thereof
- C01B33/12—Silica; Hydrates thereof, e.g. lepidoic silicic acid
- C01B33/16—Preparation of silica xerogels
- C01B33/163—Preparation of silica xerogels by hydrolysis of organosilicon compounds, e.g. ethyl orthosilicate
Abstract
Controlled release ceramic particles, processes for their preparation, controlled release ceramic particles prepared by such processes, compositions comprising such controlled release ceramic particles and methods of using controlled release ceramic particles are described. In one form each of the controlled release ceramic particles has an active material(s) substantially homogeneously dispersed throughout the particles, wherein the active material(s) is capable of being released from said particles, and the active material(s) in said particles is substantially protected from degradation until release of the active material(s) from the particles.
Claims (29)
1. Controlled release ceramic particles, wherein each of said particles has an active material substantially homogeneously dispersed throughout the particles and wherein the active material is capable of being released from said particles.
2. Controlled release ceramic particles according to claim 1 wherein said active material in said particles is incorporated within said particles so as to be substantially protected from degradation until release of the active material from the particles.
3. Controlled release ceramic particles according to claim 1 wherein said particles contain less than about 2 wt% surfactant.
4. Controlled release ceramic particles according to claim 1 wherein said ceramic particles comprise an oxide selected from the group consisting of silica, zirconia, alumina and titania.
5. Controlled release ceramic particles according to claim 1 wherein said ceramic particles comprise silica.
6. Controlled release ceramic particles according to claim 1 wherein said ceramic particles are substantially monodispersed.
7. A process of preparing controlled release ceramic particles comprising:
(a) preparing a reverse micelle solution by mixing a surfactant with an apolar solvent;
(b) preparing a precursor solution by dissolving a gel precursor, a catalyst, a condensing agent and a soluble active material in a polar solvent;
(c) preparing an emulsion by combining the reverse micelle solution and the precursor solution;
(d) forming and aging controlled release ceramic particles, wherein each of said particles has the active material substantially homogeneously dispersed throughout the particle and wherein the active material is capable of being released from said particle, by condensing the precursor in the emulsion.
(a) preparing a reverse micelle solution by mixing a surfactant with an apolar solvent;
(b) preparing a precursor solution by dissolving a gel precursor, a catalyst, a condensing agent and a soluble active material in a polar solvent;
(c) preparing an emulsion by combining the reverse micelle solution and the precursor solution;
(d) forming and aging controlled release ceramic particles, wherein each of said particles has the active material substantially homogeneously dispersed throughout the particle and wherein the active material is capable of being released from said particle, by condensing the precursor in the emulsion.
8. The process of claim 7 wherein step (b) comprises:
(b) preparing a precursor solution by dissolving a gel precursor selected from the group consisting of a silica precursor, an alumina precursor and a titanic precursor, a catalyst, a condensing agent and a soluble active material in a polar solvent.
(b) preparing a precursor solution by dissolving a gel precursor selected from the group consisting of a silica precursor, an alumina precursor and a titanic precursor, a catalyst, a condensing agent and a soluble active material in a polar solvent.
9. The process of claim 7 wherein step (b) comprises:
(b) preparing a precursor solution by dissolving a silica gel precursor, a catalyst, a condensing agent and a soluble active material in a polar solvent.
(b) preparing a precursor solution by dissolving a silica gel precursor, a catalyst, a condensing agent and a soluble active material in a polar solvent.
10. The process of claim 7 wherein step (d) comprises:
(d) forming and aging substantially monodispersed controlled release ceramic particles, wherein each of said particles has the active material substantially homogeneously dispersed throughout the particle, the active material is capable of being released from said particle and the active material in said particles is incorporated so as to be substantially protected from degradation until release of the active material from the particles, by condensing the precursor in the emulsion.
(d) forming and aging substantially monodispersed controlled release ceramic particles, wherein each of said particles has the active material substantially homogeneously dispersed throughout the particle, the active material is capable of being released from said particle and the active material in said particles is incorporated so as to be substantially protected from degradation until release of the active material from the particles, by condensing the precursor in the emulsion.
11. The process of claim 7 further comprising:
(e) separating said formed and aged controlled release ceramic particles from said emulsion.
(e) separating said formed and aged controlled release ceramic particles from said emulsion.
12. The process of claim 11 further comprising:
(e) removing surfactant from said formed and aged controlled release ceramic particles.
(e) removing surfactant from said formed and aged controlled release ceramic particles.
13. A process of preparing controlled release ceramic particles comprising:
(a') preparing a reverse micelle solution by mixing a surfactant with an apolar solvent and a hydrophilic first active material;
(b') preparing a precursor solution by dissolving a gel precursor, a catalyst, a condensing agent and optionally a soluble second active material in a polar solvent that is immiscible with the apolar solvent in (a');
(c') preparing an emulsion by combining the reverse micelle solution and the precursor solution; and (d') forming and aging controlled release ceramic particles, wherein each of said particles has the active material substantially homogeneously dispersed throughout the particle and wherein the active material is capable of being released from each of said particles, by condensing the precursor in the emulsion.
(a') preparing a reverse micelle solution by mixing a surfactant with an apolar solvent and a hydrophilic first active material;
(b') preparing a precursor solution by dissolving a gel precursor, a catalyst, a condensing agent and optionally a soluble second active material in a polar solvent that is immiscible with the apolar solvent in (a');
(c') preparing an emulsion by combining the reverse micelle solution and the precursor solution; and (d') forming and aging controlled release ceramic particles, wherein each of said particles has the active material substantially homogeneously dispersed throughout the particle and wherein the active material is capable of being released from each of said particles, by condensing the precursor in the emulsion.
14. The process of claim 13 wherein step (b') comprises:
(b') preparing a precursor solution by dissolving a silica gel precursor, a catalyst, a condensing agent and optionally a soluble second active material in a polar solvent that is immiscible with the apolar solvent in (a').
(b') preparing a precursor solution by dissolving a silica gel precursor, a catalyst, a condensing agent and optionally a soluble second active material in a polar solvent that is immiscible with the apolar solvent in (a').
15. The process of claim 13 wherein step (d') comprises:
(d') forming and aging controlled release ceramic particles, wherein each of said particles has the active material substantially homogeneously dispersed throughout the particle, the active material is capable of being released from said particle and the active material in each of said particles is incorporated so as to be substantially protected from degradation until release of the active material from the particle, by condensing the precursor in the emulsion.
(d') forming and aging controlled release ceramic particles, wherein each of said particles has the active material substantially homogeneously dispersed throughout the particle, the active material is capable of being released from said particle and the active material in each of said particles is incorporated so as to be substantially protected from degradation until release of the active material from the particle, by condensing the precursor in the emulsion.
16. The process of claim 15 further comprising:
(e') separating said formed and aged controlled release ceramic particles from said emulsion.
(e') separating said formed and aged controlled release ceramic particles from said emulsion.
17. The process of claim 16 further comprising:
(e') removing surfactant from said formed and aged controlled release ceramic particles.
(e') removing surfactant from said formed and aged controlled release ceramic particles.
18. A process of preparing controlled release ceramic particles comprising:
(a") preparing a precursor solution by mixing a gel precursor, an active material and optionally a solvent;
(b") preparing a condensing solution by mixing a catalyst, a condensing agent and optionally a solvent, said condensing solution being substantially immiscible with said precursor solution;
(c") combining the precursor solution and the condensing solution to form a mixture and preparing an emulsion by spontaneously emulsifying the mixture in the absence of a surfactant; and (d") forming and aging controlled release ceramic particles, wherein each of said particles has the active material substantially homogeneously dispersed throughout the particle and the active material is capable of being released from each of said particles, by condensing the precursor in the emulsion.
(a") preparing a precursor solution by mixing a gel precursor, an active material and optionally a solvent;
(b") preparing a condensing solution by mixing a catalyst, a condensing agent and optionally a solvent, said condensing solution being substantially immiscible with said precursor solution;
(c") combining the precursor solution and the condensing solution to form a mixture and preparing an emulsion by spontaneously emulsifying the mixture in the absence of a surfactant; and (d") forming and aging controlled release ceramic particles, wherein each of said particles has the active material substantially homogeneously dispersed throughout the particle and the active material is capable of being released from each of said particles, by condensing the precursor in the emulsion.
19. The process of claim 18 wherein step (a") comprises:
(a") preparing a precursor solution by dissolving a silica gel precursor, a catalyst, a condensing agent and optionally a soluble second active material in a polar solvent.
(a") preparing a precursor solution by dissolving a silica gel precursor, a catalyst, a condensing agent and optionally a soluble second active material in a polar solvent.
20. The process of claim 18 wherein step (d") comprises:
(d") forming and aging controlled release ceramic particles, wherein each of said particles has the active material substantially homogeneously dispersed throughout the particle, the active material is capable of being released from each of said particles and the active material in each of said particles is incorporated so as to be substantially protected from degradation until release of the active material from the particle, by condensing the precursor in the emulsion.
(d") forming and aging controlled release ceramic particles, wherein each of said particles has the active material substantially homogeneously dispersed throughout the particle, the active material is capable of being released from each of said particles and the active material in each of said particles is incorporated so as to be substantially protected from degradation until release of the active material from the particle, by condensing the precursor in the emulsion.
21. The process of claim 20 further comprising:
(e'') separating said formed and aged controlled release ceramic particles from said emulsion.
(e'') separating said formed and aged controlled release ceramic particles from said emulsion.
22. A process of preparing controlled release ceramic particles comprising:
(a"') preparing a reverse micelle solution by mixing a surfactant with an apolar solvent;
(b"') preparing an hydrophilic solution by dissolving a catalyst, a condensing agent and a soluble active material in a polar solvent:
(c"') preparing an emulsion by combining the reverse micelle solution and the hydrophilic solution;
(d"') adding a gel precursor to emulsion.; and (e"') forming and aging controlled release ceramic particles, wherein each of said particles has the active material substantially homogeneously dispersed throughout the particle and wherein the active material is capable of being released from each of said particles, by condensing the precursor in the emulsion.
(a"') preparing a reverse micelle solution by mixing a surfactant with an apolar solvent;
(b"') preparing an hydrophilic solution by dissolving a catalyst, a condensing agent and a soluble active material in a polar solvent:
(c"') preparing an emulsion by combining the reverse micelle solution and the hydrophilic solution;
(d"') adding a gel precursor to emulsion.; and (e"') forming and aging controlled release ceramic particles, wherein each of said particles has the active material substantially homogeneously dispersed throughout the particle and wherein the active material is capable of being released from each of said particles, by condensing the precursor in the emulsion.
23. The process of claim 22 wherein step (d"') comprises:
(d"') adding a silica gel precursor to the emulsion.
(d"') adding a silica gel precursor to the emulsion.
24. The process of claim 22 wherein. step (e"') comprises:
(e"') forming and aging controlled release ceramic particles, wherein each of said particles has the active material substantially homogeneously dispersed throughout the particle, the active material is capable of being released from each of said particles and the active material in each of said particles is incorporated within said particle so as to be substantially protected from degradation until release of the active material from the particle, by condensing the precursor in the emulsion.
(e"') forming and aging controlled release ceramic particles, wherein each of said particles has the active material substantially homogeneously dispersed throughout the particle, the active material is capable of being released from each of said particles and the active material in each of said particles is incorporated within said particle so as to be substantially protected from degradation until release of the active material from the particle, by condensing the precursor in the emulsion.
25. The process of claim 22 further comprising:
(f'") separating said formed and aged controlled release ceramic particles from said emulsion.
(f'") separating said formed and aged controlled release ceramic particles from said emulsion.
26. The process of claim 23 further comprising:
(f'") removing surfactant from said from and aged controlled release ceramics particles.
(f'") removing surfactant from said from and aged controlled release ceramics particles.
27. Controlled release ceramic particles prepared by tho process of any one of claims 7, 13, 18 or 22.
28. The process of any one of claims 7, 13, 18 or 22 further comprising:
separating said formed and aged controlled release ceramic particles from said emulsion by adding an ionic salt to the emulsion whereby the particles are dispersed in a resulting solution; and freeze drying said solution, to form a solid in which unaggregated ceramic particles are isolated within a matrix of the ionic salt.
separating said formed and aged controlled release ceramic particles from said emulsion by adding an ionic salt to the emulsion whereby the particles are dispersed in a resulting solution; and freeze drying said solution, to form a solid in which unaggregated ceramic particles are isolated within a matrix of the ionic salt.
29. An isotonic solution obtained by dispersing the solid obtained by the process o~ claim 28 in water.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPQ5733 | 2000-02-21 | ||
| AUPQ5733A AUPQ573300A0 (en) | 2000-02-21 | 2000-02-21 | Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use |
| PCT/AU2001/000173 WO2001062232A1 (en) | 2000-02-21 | 2001-02-21 | Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2399279A1 true CA2399279A1 (en) | 2001-08-30 |
| CA2399279C CA2399279C (en) | 2011-02-15 |
Family
ID=3819844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2399279A Expired - Lifetime CA2399279C (en) | 2000-02-21 | 2001-02-21 | Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US7258874B2 (en) |
| EP (1) | EP1257259B1 (en) |
| JP (2) | JP4986357B2 (en) |
| AT (1) | ATE473733T1 (en) |
| AU (1) | AUPQ573300A0 (en) |
| CA (1) | CA2399279C (en) |
| DE (1) | DE60142552D1 (en) |
| DK (1) | DK1257259T3 (en) |
| ES (1) | ES2349190T3 (en) |
| MX (1) | MXPA02008117A (en) |
| NZ (1) | NZ520796A (en) |
| PT (1) | PT1257259E (en) |
| WO (1) | WO2001062232A1 (en) |
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- 2000-02-21 AU AUPQ5733A patent/AUPQ573300A0/en not_active Abandoned
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2001
- 2001-02-21 MX MXPA02008117A patent/MXPA02008117A/en active IP Right Grant
- 2001-02-21 EP EP01907235A patent/EP1257259B1/en not_active Expired - Lifetime
- 2001-02-21 PT PT01907235T patent/PT1257259E/en unknown
- 2001-02-21 ES ES01907235T patent/ES2349190T3/en not_active Expired - Lifetime
- 2001-02-21 CA CA2399279A patent/CA2399279C/en not_active Expired - Lifetime
- 2001-02-21 JP JP2001561299A patent/JP4986357B2/en not_active Expired - Fee Related
- 2001-02-21 WO PCT/AU2001/000173 patent/WO2001062232A1/en active IP Right Grant
- 2001-02-21 DK DK01907235.4T patent/DK1257259T3/en active
- 2001-02-21 US US10/204,462 patent/US7258874B2/en not_active Expired - Lifetime
- 2001-02-21 NZ NZ520796A patent/NZ520796A/en not_active IP Right Cessation
- 2001-02-21 AT AT01907235T patent/ATE473733T1/en active
- 2001-02-21 DE DE60142552T patent/DE60142552D1/en not_active Expired - Lifetime
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2007
- 2007-08-20 US US11/841,650 patent/US7357948B2/en not_active Expired - Fee Related
- 2007-08-20 US US11/841,669 patent/US7354602B2/en not_active Expired - Fee Related
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2009132411A1 (en) * | 2008-04-28 | 2009-11-05 | The University Of British Columbia | Polymer-free drug delivery system for implantable medical devices |
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| AUPQ573300A0 (en) | 2000-03-16 |
| ES2349190T3 (en) | 2010-12-28 |
| ATE473733T1 (en) | 2010-07-15 |
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| CA2399279C (en) | 2011-02-15 |
| US7258874B2 (en) | 2007-08-21 |
| US7585521B2 (en) | 2009-09-08 |
| US20080274199A1 (en) | 2008-11-06 |
| JP4986357B2 (en) | 2012-07-25 |
| US7354603B2 (en) | 2008-04-08 |
| PT1257259E (en) | 2010-08-05 |
| NZ520796A (en) | 2004-03-26 |
| WO2001062232A1 (en) | 2001-08-30 |
| EP1257259A1 (en) | 2002-11-20 |
| DE60142552D1 (en) | 2010-08-26 |
| JP2012072194A (en) | 2012-04-12 |
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