CA2406972C - Cross-linked collagen matrices and methods for their preparation - Google Patents

Cross-linked collagen matrices and methods for their preparation Download PDF

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Publication number
CA2406972C
CA2406972C CA2406972A CA2406972A CA2406972C CA 2406972 C CA2406972 C CA 2406972C CA 2406972 A CA2406972 A CA 2406972A CA 2406972 A CA2406972 A CA 2406972A CA 2406972 C CA2406972 C CA 2406972C
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Prior art keywords
collagen
cross
linked
matrix
incubating
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Expired - Lifetime
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CA2406972A
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French (fr)
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CA2406972A1 (en
Inventor
Matitiau Noff
Pitaru Shahar
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ColBar R and D Ltd
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ColBar R and D Ltd
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • C08H1/06—Macromolecular products derived from proteins derived from horn, hoofs, hair, skin or leather

Abstract

A method for preparing cross-linked collagen, and cross-linked collagen products. The method includes incubating collagen in a solution including water, at least one polar solvent and at least one sugar, to form cross-linked collagen. The accompanying figure shows the effect of treatment with reducing sugar (D-ribose) and alcohol on particulate collagen degradation by bacterial collagenase. The solution may include a buffer having a suitable pH and ionic strength. The method may include removing excess unreacted sugar(s) and polar solvent(s) by washing the cross-linked collagen or by other methods. The method may also include dehydrating the cross-linked collagen, and may include subjecting the cross-linked collagen to critical point drying, or subjecting the collagen to drying or freeze-drying prior to cross-linking. The collagen may be prepared from atelopeptide collagen to reduce antigenicity, but may also be prepared from other suitable collagen types. The concentration and type of the polar solvent(s), the concentration and type of the reducing sugar(s), and the incubation duration may be varied to control the degree of cross-linking. The cross-linked collagen product may be in the form of a wet or dry matrix or membrane or may be suspended in a liquid in the form of an injectable preparation. The method may be applied to collagenous proteins and collagen-like peptides.

Claims (35)

THE EMBODIMENTS OF THE INVENTION FOR WHICH AN EXCLUSIVE
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A method for preparing cross-linked collagen having improved resistance to collagenase degradation, the method comprising a step of incubating collagen in a solution comprising water, (D)-ribose as a reducing sugar, and at least one polar solvent selected from the group consisting of methanol, ethanol, propanol, isopropanol, acetone, tetrahydrofuran, dimethylsulfoxide, and combinations thereof in an amount of between 5%-85% (v/v) to form cross-linked collagen, wherein the cross-linked collagen has improved resistance to collagenase degradation in comparison to cross-linked collagen prepared without said incubating step.
2. The method according to claim 1, wherein said solution is a buffered solution.
3. The method according to claim 1, wherein said solution comprises phosphate buffered saline.
4. The method according to claim 1, wherein said solution comprises water in the range of 15% - 95% (v/v) and a buffer.
5. The method according to claim 1, wherein said collagen is selected from native collagen, fibrillar collagen, fibrillar atelopeptide collagen, lyophylized collagen, collagen obtained from animal sources, human collagen, recombinant collagen, pepsinized collagen, reconstituted collagen, and combinations thereof.
6. The method according to claim 1, wherein said collagen comprises fibrillar collagen reconstituted from monomolecular atelopeptide collagen.
7. The method according to claim 1, wherein said collagen is obtained by reconstituting monomolecular atelopeptide collagen obtained by proteolytic digestion of native collagen.
8. The method according to claim 1, wherein at least one substance selected from the group consisting of an antimicrobial agent, an anti-inflammatory agent, a factor having tissue inductive properties, and combinations thereof is added to the solution in which said step of incubating is performed.
9. The method according to claim 8, wherein said cross-linked collagen forms a matrix and said at least one substance becomes immobilized within said matrix.
10. The method according to claim 1, wherein said at least one polar solvent is ethanol.
11. The method according to claim 10, wherein said solution comprises water in the range of 15% - 95% (v/v) and ethanol in the range of 5%-85% (v/v).
12. The method according to claim 10, wherein said solution comprises water in the range of 25% - 50% (v/v) and ethanol in the range of 50%-75% (v/v).
13. The method according to claim 10, wherein said solution comprises about 30% water (v/v), and about 70% ethanol (v/v).
14. The method according to claim 10, wherein the concentration of (D)-ribose in said solution is in the range of 0.1% - 5% (w/v).
15. The method according to claim 10, wherein the concentration of (D)-ribose in said solution is in the range of 0.5% - 3% (w/v).
16. The method according to claim 1, further including a step of washing said cross-linked collagen after said step of incubating to remove said at least one polar solvent and excess of said (D)-ribose.
17. The method according to claim 1, further including a step of dehydrating said cross-linked collagen.
18. The method according to claim 17, further including a step of subjecting said cross-linked collagen to critical point drying.
19. The method according to claim 1, further including a step of drying or freeze-drying said collagen prior to said step of incubating.
20. The method according to claim 1, further including a step of drying or freeze-drying said cross-linked collagen.
21. A cross-linked collagen having improved resistance to collagenase degradation prepared by a method comprising a step of incubating collagen in a solution comprising water, (D)-ribose as a reducing sugar and at least one polar solvent selected from the group consisting of methanol, ethanol, propanol, isopropanol, acetone, tetrahydrofuran, dimethylsulfoxide, and combinations thereof in an amount of between 5%-85% (v/v), to form cross-linked collagen, wherein the cross-linked collagen has improved resistance to collagenase degradation in comparison to cross-linked collagen prepared without said incubating step.
22. The method according to claim 1, further including a step of controlling the duration of said incubating of said step of incubating to control the degree of cross linking of said cross-linked collagen.
23. The method according to claim 1, further including a step of controlling the concentration of said (D)-ribose used in said step of incubating to control the degree of cross linking of said cross-linked collagen.
24. The method according to claim 1, further including a step of controlling the concentration of said at least one polar solvent used in said step of incubating to control the degree of cross linking of said cross-linked collagen.
25. The method according to claim 1, further including a step of removing at least some of the unreacted amount of said(D)-ribose, and removing at least some of said at least one polar solvent.
26. The method according to claim 1, further including a step of washing said cross-linked collagen to remove at least some of the unreacted amount of said (D)-ribose and to remove at least some of said at least one polar solvent.
27. A cross-linked fibrillar collagen matrix having improved resistance to collagenase degradation obtained by a process for its preparation from fibrillar collagen, said process comprising the following steps:
providing a matrix comprising reconstituted fibrillar collagen; and incubating said matrix in a solution comprising water, (D)-ribose as a reducing sugar, and at least one polar solvent selected from the group consisting of methanol, ethanol, propanol, isopropanol, acetone, tetrahydrofuran, dimethylsulfoxide, and combinations thereof in the range of 5%-85% (v/v), for cross-linking said fibrillar collagen to form a cross-linked fibrillar collagen matrix, wherein the cross-linked fibrillar collagen matrix has improved resistance to collagenase degradation in comparison to cross-linked fibrillar collagen matrices prepared without said incubating step.
28. The cross-linked fibrillar collagen matrix according to claim 27, in the form of an implantable device.
29. The matrix according to claim 28, wherein said implantable device is a collagen based membrane barrier for guided tissue regeneration.
30. The matrix according to claim 27, wherein said process further includes a step of washing said cross-linked collagen matrix after said step of incubating to remove at least some of said at least one polar solvent and unreacted excess of said (D)-ribose.
31. The matrix according to claim 27, wherein said process further includes a step of dehydrating said cross-linked fibrillar collagen matrix.
32. The matrix according to claim 27, wherein said process further includes a step of subjecting said cross-linked fibrillar collagen matrix to critical point drying.
33. The matrix according to claim 27, wherein said process further includes a step of drying or freeze-drying said cross-linked fibrillar collagen matrix.
34. The matrix according to claim 27, wherein said fibrillar collagen comprises fibrillar collagen reconstituted from monomolecular atelopeptide collagen.
35. The matrix according to claim 27, wherein said fibrillar collagen is prepared by reconstituting monomolecular atelopeptide collagen obtained by proteolytic digestion of native collagen.
CA2406972A 2000-04-18 2001-04-17 Cross-linked collagen matrices and methods for their preparation Expired - Lifetime CA2406972C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19798900P 2000-04-18 2000-04-18
US60/197,989 2000-04-18
US09/828,189 2001-04-09
US09/828,189 US6682760B2 (en) 2000-04-18 2001-04-09 Cross-linked collagen matrices and methods for their preparation
PCT/IL2001/000351 WO2001079342A2 (en) 2000-04-18 2001-04-17 Cross-linked collagen matrices and methods for their preparation

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CA2406972A1 CA2406972A1 (en) 2001-10-25
CA2406972C true CA2406972C (en) 2014-10-14

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US (1) US6682760B2 (en)
EP (1) EP1280545B1 (en)
JP (1) JP4664568B2 (en)
AT (1) ATE354368T1 (en)
AU (1) AU784758B2 (en)
BR (1) BRPI0110312B8 (en)
CA (1) CA2406972C (en)
DE (1) DE60126757T2 (en)
MX (1) MXPA02010343A (en)
WO (1) WO2001079342A2 (en)

Families Citing this family (132)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9080146B2 (en) * 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
US20040010251A1 (en) * 2001-12-10 2004-01-15 Shahar Pitaru Methods, devices, and preparations for intervertebral disc treatment
NZ535136A (en) 2002-02-21 2006-03-31 Encelle Inc Immobilized bioactive hydrogel matrices as surface coatings
US20080086792A1 (en) 2006-10-13 2008-04-17 Thomas Charles Kuracina Method and apparatus for diverting sweat, liquid, moisture or the like from an eye
US20080226723A1 (en) * 2002-07-05 2008-09-18 Celonova Biosciences, Inc. Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same
FR2861734B1 (en) 2003-04-10 2006-04-14 Corneal Ind CROSSLINKING OF LOW AND HIGH MOLECULAR MASS POLYSACCHARIDES; PREPARATION OF INJECTABLE SINGLE PHASE HYDROGELS; POLYSACCHARIDES AND HYDROGELS OBTAINED
EP1701729B1 (en) 2003-12-31 2018-05-02 Warsaw Orthopedic, Inc. Improved bone matrix compositions and methods
US20070190101A1 (en) * 2004-03-31 2007-08-16 Chunlin Yang Flowable bone grafts
AU2005298344B2 (en) 2004-10-25 2011-02-10 Varian Medical Systems, Inc. Loadable polyphosphazene-comprising particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US9114162B2 (en) * 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US9107850B2 (en) * 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US7976518B2 (en) 2005-01-13 2011-07-12 Corpak Medsystems, Inc. Tubing assembly and signal generator placement control device and method for use with catheter guidance systems
US8048446B2 (en) * 2005-05-10 2011-11-01 Drexel University Electrospun blends of natural and synthetic polymer fibers as tissue engineering scaffolds
US20070042326A1 (en) * 2005-06-01 2007-02-22 Osseous Technologies Of America Collagen antral membrane expander
US8784336B2 (en) 2005-08-24 2014-07-22 C. R. Bard, Inc. Stylet apparatuses and methods of manufacture
CA2627907C (en) 2005-11-01 2014-06-17 Osteotech, Inc. Osteoinductive composition comprising osteoinductive factors recovered from mineralized bone and a carrier
DE102006011211A1 (en) * 2006-03-02 2007-09-06 Ossacur Ag Material for the treatment of bone and / or cartilage defects
US20080026032A1 (en) * 2006-07-27 2008-01-31 Zubery Yuval Composite implants for promoting bone regeneration and augmentation and methods for their preparation and use
US7794407B2 (en) 2006-10-23 2010-09-14 Bard Access Systems, Inc. Method of locating the tip of a central venous catheter
US8133484B2 (en) 2006-12-15 2012-03-13 Lifebond Ltd Hemostatic materials and dressing
KR101428122B1 (en) 2006-12-15 2014-08-07 라이프본드 엘티디. Gelatin-transglutaminase hemostatic dressings and sealants
JP4609897B2 (en) * 2006-12-28 2011-01-12 学校法人帝京大学 Collagen composition and method for producing the same
US20080260794A1 (en) * 2007-02-12 2008-10-23 Lauritzen Nels J Collagen products and methods for producing collagen products
US9056151B2 (en) * 2007-02-12 2015-06-16 Warsaw Orthopedic, Inc. Methods for collagen processing and products using processed collagen
BRPI0811784A2 (en) * 2007-05-23 2011-05-10 Allergan Inc cross-linked collagen and use thereof
US20080306610A1 (en) * 2007-06-07 2008-12-11 Zimmer Orthobiologics, Inc. Tissue processing for nonimmunogenic implants
WO2008157492A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Osteoinductive demineralized cancellous bone
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
AU2008265852B2 (en) 2007-06-15 2014-04-17 Warsaw Orthopedic, Inc. Method of treating tissue
CA2690457C (en) 2007-06-15 2018-02-20 Osteotech, Inc. Bone matrix compositions and methods
US20090004455A1 (en) * 2007-06-27 2009-01-01 Philippe Gravagna Reinforced composite implant
US8932619B2 (en) * 2007-06-27 2015-01-13 Sofradim Production Dural repair material
US9358113B2 (en) 2007-07-10 2016-06-07 Warsaw Orthopedic, Inc. Delivery system
US20090068250A1 (en) * 2007-09-07 2009-03-12 Philippe Gravagna Bioresorbable and biocompatible compounds for surgical use
ES2446544T3 (en) 2007-10-19 2014-03-10 Warsaw Orthopedic, Inc. Demineralized bone matrix compositions and methods
US20090110738A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Cosmetic and Reconstructive Tissue Augmentation Applications and Methods of Preparing and Using the Same
US20090111763A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable polymeric particles for bone augmentation and methods of preparing and using the same
US20090110731A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Microparticles for Therapeutic Use in Alopecia and Methods of Preparing and Using the Same
US20090110730A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Marking or Masking Individuals and Methods of Preparing and Using the Same
EP3563883B1 (en) * 2007-11-09 2022-10-26 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
EP2207424B1 (en) 2007-11-16 2014-06-04 Allergan, Inc. Compositions and methods for treating purpura
US9456766B2 (en) 2007-11-26 2016-10-04 C. R. Bard, Inc. Apparatus for use with needle insertion guidance system
ES2651898T3 (en) 2007-11-26 2018-01-30 C.R. Bard Inc. Integrated system for intravascular catheter placement
US8394782B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US9308068B2 (en) 2007-12-03 2016-04-12 Sofradim Production Implant for parastomal hernia
EP3178442A1 (en) * 2007-12-07 2017-06-14 C.R. Bard Inc. Implantable prosthesis
CN104491845A (en) 2008-04-18 2015-04-08 科尔普兰特有限公司 Methods Of Generating And Using Procollagen
CA2728186A1 (en) * 2008-06-18 2009-12-23 Lifebond Ltd Methods and devices for use with sealants
CN102124058B (en) 2008-06-18 2014-05-28 生命连结有限公司 Improved cross-linked compositions
US9242026B2 (en) * 2008-06-27 2016-01-26 Sofradim Production Biosynthetic implant for soft tissue repair
US8357795B2 (en) 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
ES2829971T3 (en) 2008-09-02 2021-06-02 Tautona Group Lp Hyaluronic acid threads and / or derivatives thereof, methods to manufacture them and uses thereof
EP2384205A1 (en) 2009-01-02 2011-11-09 Ramot at Tel-Aviv University Ltd. Fibrin and fibrinogen matrices and uses of same
WO2010093950A1 (en) 2009-02-12 2010-08-19 Osteotech, Inc. Delivery system cartridge
US20120135376A1 (en) * 2009-03-30 2012-05-31 Osseous Technologies Of America Collagen Biomaterial Wedge
US9532724B2 (en) 2009-06-12 2017-01-03 Bard Access Systems, Inc. Apparatus and method for catheter navigation using endovascular energy mapping
FR2949688B1 (en) 2009-09-04 2012-08-24 Sofradim Production FABRIC WITH PICOTS COATED WITH A BIORESORBABLE MICROPOROUS LAYER
AU2010334412B2 (en) 2009-12-22 2016-02-04 Lifebond Ltd Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
JP2013518676A (en) 2010-02-02 2013-05-23 シー・アール・バード・インコーポレーテッド Apparatus and method for locating catheter navigation and tip
EP2544652A2 (en) 2010-03-12 2013-01-16 Allergan Industrie SAS A fluid composition comprising a hyaluronan polymer and mannitol for improving skin condition.
DK2550027T4 (en) 2010-03-22 2019-05-13 Allergan Inc CROSS-BAND POLYSACCHARID AND PROTEIN POLYSACCHARID HYDROCHLORIC PRODUCTS
US8460691B2 (en) 2010-04-23 2013-06-11 Warsaw Orthopedic, Inc. Fenestrated wound repair scaffold
US8790699B2 (en) 2010-04-23 2014-07-29 Warsaw Orthpedic, Inc. Foam-formed collagen strand
CN103037762B (en) 2010-05-28 2016-07-13 C·R·巴德股份有限公司 For inserting, with pin, the device that guiding system is used together
CN103118713B (en) 2010-08-05 2016-06-01 生命连结有限公司 Dry composition wound dressing and binding agent
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
MX338127B (en) 2010-08-20 2016-04-04 Bard Inc C R Reconfirmation of ecg-assisted catheter tip placement.
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
US9611312B2 (en) * 2010-11-23 2017-04-04 Elastagen Pty. Limited Preparation and/or formulation of proteins cross-linked with polysaccharides
EP2585084A4 (en) 2011-02-14 2014-12-31 Mimedx Group Inc Micronized placental tissue compositions and methods for making and using the same
AU2012217982B2 (en) 2011-02-14 2016-05-12 Mimedx Group Inc. Tissue grafts modified with a cross-linking agent and method of making and using the same
FR2972626B1 (en) 2011-03-16 2014-04-11 Sofradim Production PROSTHETIC COMPRISING A THREE-DIMENSIONAL KNIT AND ADJUSTED
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
EP2714002B1 (en) 2011-06-03 2019-04-03 Allergan, Inc. Dermal filler compositions including antioxidants
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
FR2977789B1 (en) 2011-07-13 2013-07-19 Sofradim Production PROSTHETIC FOR UMBILIC HERNIA
FR2977790B1 (en) 2011-07-13 2013-07-19 Sofradim Production PROSTHETIC FOR UMBILIC HERNIA
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
EP2760431A1 (en) 2011-09-30 2014-08-06 Sofradim Production Multilayer implants for delivery of therapeutic agents
EP2760494B1 (en) 2011-09-30 2017-04-19 Sofradim Production Reversible stiffening of light weight mesh
CA2854160A1 (en) 2011-11-02 2013-05-10 Halscion, Inc. Methods and compositions for wound treatment
CA2857636C (en) 2011-12-22 2020-06-23 Mimedx Group Inc. Cross-linked dehydrated placental tissue grafts and methods for making and using the same
FR2985271B1 (en) 2011-12-29 2014-01-24 Sofradim Production KNITTED PICOTS
FR2985170B1 (en) 2011-12-29 2014-01-24 Sofradim Production PROSTHESIS FOR INGUINAL HERNIA
TR201907156T4 (en) 2012-01-09 2019-06-21 Innocoll Pharm Ltd A modified collagen.
RU2665366C2 (en) 2012-05-11 2018-08-29 АрТиАй СЕРДЖИКАЛ, ИНК. Xenograft soft tissue implants and methods of making and using
FR2994185B1 (en) 2012-08-02 2015-07-31 Sofradim Production PROCESS FOR THE PREPARATION OF A POROUS CHITOSAN LAYER
US11338063B2 (en) 2012-08-15 2022-05-24 Mimedx Group, Inc. Placental tissue grafts modified with a cross-linking agent and methods of making and using the same
FR2995779B1 (en) 2012-09-25 2015-09-25 Sofradim Production PROSTHETIC COMPRISING A TREILLIS AND A MEANS OF CONSOLIDATION
FR2995778B1 (en) 2012-09-25 2015-06-26 Sofradim Production ABDOMINAL WALL REINFORCING PROSTHESIS AND METHOD FOR MANUFACTURING THE SAME
FR2995788B1 (en) 2012-09-25 2014-09-26 Sofradim Production HEMOSTATIC PATCH AND PREPARATION METHOD
AU2013322268B2 (en) 2012-09-28 2017-08-31 Sofradim Production Packaging for a hernia repair device
US8946163B2 (en) 2012-11-19 2015-02-03 Mimedx Group, Inc. Cross-linked collagen comprising metallic anticancer agents
US9155799B2 (en) 2012-11-19 2015-10-13 Mimedx Group, Inc. Cross-linked collagen with at least one bound antimicrobial agent for in vivo release of the agent
US8940684B2 (en) 2012-11-19 2015-01-27 Mimedx Group, Inc. Cross-linked collagen comprising an antifungal agent
KR20150126647A (en) 2013-03-04 2015-11-12 더멜, 엘엘씨 디/비/에이 에테르노젠, 엘엘씨 Injectable in situ polymerizable collagen composition
US10029030B2 (en) 2013-03-15 2018-07-24 Mimedx Group, Inc. Molded placental tissue compositions and methods of making and using the same
US10335433B2 (en) 2013-04-10 2019-07-02 Mimedx Group, Inc. NDGA polymers and metal complexes thereof
US9446142B2 (en) 2013-05-28 2016-09-20 Mimedx Group, Inc. Polymer chelator conjugates
FR3006578B1 (en) 2013-06-07 2015-05-29 Sofradim Production PROSTHESIS BASED ON TEXTILE FOR LAPAROSCOPIC PATHWAY
FR3006581B1 (en) 2013-06-07 2016-07-22 Sofradim Production PROSTHESIS BASED ON TEXTILE FOR LAPAROSCOPIC PATHWAY
WO2015031681A1 (en) 2013-08-30 2015-03-05 Mimedx Group, Inc. Micronized placental compositions comprising a chelator
US9878071B2 (en) 2013-10-16 2018-01-30 Purdue Research Foundation Collagen compositions and methods of use
AU2015206236B2 (en) 2014-01-17 2020-02-20 Mimedx Group, Inc. Method for inducing angiogenesis
US9919075B2 (en) * 2014-03-20 2018-03-20 Anexis, Llc Cohesive materials including derivatized collagens and methods of making and using them
EP3000489B1 (en) 2014-09-24 2017-04-05 Sofradim Production Method for preparing an anti-adhesion barrier film
EP3000433B1 (en) 2014-09-29 2022-09-21 Sofradim Production Device for introducing a prosthesis for hernia treatment into an incision and flexible textile based prosthesis
EP3000432B1 (en) 2014-09-29 2022-05-04 Sofradim Production Textile-based prosthesis for treatment of inguinal hernia
EP3200838B1 (en) 2014-09-30 2019-09-18 Allergan Industrie, SAS Stable hydrogel compositions including additives
EP3029189B1 (en) 2014-12-05 2021-08-11 Sofradim Production Prosthetic porous knit, method of making same and hernia prosthesis
WO2016128783A1 (en) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions and methods for improving skin appearance
EP3059255B1 (en) 2015-02-17 2020-05-13 Sofradim Production Method for preparing a chitosan-based matrix comprising a fiber reinforcement member
EP3085337B1 (en) 2015-04-24 2022-09-14 Sofradim Production Prosthesis for supporting a breast structure
US11213613B2 (en) * 2015-06-12 2022-01-04 Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences Three-dimensional tissue scaffold with stem cell attracting element and use thereof
ES2676072T3 (en) 2015-06-19 2018-07-16 Sofradim Production Synthetic prosthesis comprising a knitted fabric and a non-porous film and method of forming it
EP3195830B1 (en) 2016-01-25 2020-11-18 Sofradim Production Prosthesis for hernia repair
EP3312325B1 (en) 2016-10-21 2021-09-22 Sofradim Production Method for forming a mesh having a barbed suture attached thereto and the mesh thus obtained
CN106620815B (en) * 2016-11-10 2019-07-26 华东师范大学 Based on G- tetrad/collagen gel dressing and its preparation and application
EP3398554A1 (en) 2017-05-02 2018-11-07 Sofradim Production Prosthesis for inguinal hernia repair
US11180541B2 (en) 2017-09-28 2021-11-23 Geltor, Inc. Recombinant collagen and elastin molecules and uses thereof
CN108752604B (en) * 2018-06-07 2021-02-02 北京大清生物技术股份有限公司 Soft tissue filling material and preparation method and application thereof
EP3653171A1 (en) 2018-11-16 2020-05-20 Sofradim Production Implants suitable for soft tissue repair
CA3136691A1 (en) 2019-04-12 2020-10-15 Geltor, Inc. Recombinant elastin and production thereof
CN115298212A (en) 2020-01-24 2022-11-04 格尔托公司 Animal diet-free collagen
CN113730656A (en) * 2021-08-04 2021-12-03 中南大学湘雅二医院 Biological valve material and preparation method thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3949073A (en) 1974-11-18 1976-04-06 The Board Of Trustees Of Leland Stanford Junior University Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution
DE2929144A1 (en) 1979-07-19 1981-02-12 Behringwerke Ag METHOD FOR PRODUCING COLLAGEN
US4582640A (en) 1982-03-08 1986-04-15 Collagen Corporation Injectable cross-linked collagen implant material
US4600533A (en) 1984-12-24 1986-07-15 Collagen Corporation Collagen membranes for medical use
IL76079A (en) 1985-08-13 1991-03-10 Univ Ramot Collagen implants
US4961707A (en) 1987-12-22 1990-10-09 University Of Florida Guided periodontal tissue regeneration
US5565519A (en) * 1988-11-21 1996-10-15 Collagen Corporation Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
US4971954A (en) 1988-11-23 1990-11-20 University Of Medicine And Dentistry Of New Jersey Collagen-based matrices ribose cross-linked
US5700479A (en) 1988-12-23 1997-12-23 Guidor Ab Surgical element and method for selective tissue regeneration
US5292362A (en) 1990-07-27 1994-03-08 The Trustees Of Columbia University In The City Of New York Tissue bonding and sealing composition and method of using the same
US5206028A (en) 1991-02-11 1993-04-27 Li Shu Tung Dense collagen membrane matrices for medical uses
FR2679778B1 (en) 1991-08-02 1995-07-07 Coletica USE OF CROLAGEN CROSSLINKED BY A CROSSLINKING AGENT FOR THE MANUFACTURE OF A SLOW RESORPTIVE, BIOCOMPATIBLE, SUTURABLE MEMBRANE, AS WELL AS SUCH A MEMBRANE.
DE4302708C2 (en) 1993-02-01 1995-06-01 Kirsch Axel Covering membrane
GB9400163D0 (en) 1994-01-06 1994-03-02 Geistlich Soehne Ag Membrane
IL110367A (en) 1994-07-19 2007-05-15 Colbar Lifescience Ltd Collagen-based matrix
US5718012A (en) 1996-05-28 1998-02-17 Organogenesis, Inc. Method of strength enhancement of collagen constructs
US5866165A (en) 1997-01-15 1999-02-02 Orquest, Inc. Collagen-polysaccharide matrix for bone and cartilage repair
US6309670B1 (en) 1997-01-15 2001-10-30 Orquest, Inc. Collagen-polysaccharide matrix for treatment of bone tumors
US6156531A (en) 1998-07-20 2000-12-05 Sulzer Carbomedics Inc. Cross-linking tissue with a compound having a C8 to C40 aliphatic chain
US6177514B1 (en) 1999-04-09 2001-01-23 Sulzer Carbomedics Inc. Blocked functional reagants for cross-linking biological tissues

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