CA2412648A1 - Use of b-type natriuretic peptide as a prognostic indicator in acute coronary syndromes - Google Patents

Use of b-type natriuretic peptide as a prognostic indicator in acute coronary syndromes Download PDF

Info

Publication number
CA2412648A1
CA2412648A1 CA002412648A CA2412648A CA2412648A1 CA 2412648 A1 CA2412648 A1 CA 2412648A1 CA 002412648 A CA002412648 A CA 002412648A CA 2412648 A CA2412648 A CA 2412648A CA 2412648 A1 CA2412648 A1 CA 2412648A1
Authority
CA
Canada
Prior art keywords
acute coronary
coronary syndromes
wave
natriuretic peptide
type natriuretic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002412648A
Other languages
French (fr)
Other versions
CA2412648C (en
Inventor
Jeffrey R. Dahlen
Gunars E. Valkirs
Kenneth F. Buechler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alere San Diego Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25269150&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2412648(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2412648A1 publication Critical patent/CA2412648A1/en
Application granted granted Critical
Publication of CA2412648C publication Critical patent/CA2412648C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Brain natriuretic peptide [BNP, proBNP]; Cardionatrin; Cardiodilatin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction

Abstract

The present invention relates to materials and procedures for evaluating the prognosis of patients suffering from acute coronary syndromes. In particular, the level of BNP, or a marker related to BNP, in a patient sample, alone or in combination with one or more other prognostic markers, provides prognostic information useful for predicting near-term morbidity and/or mortality across the entire spectrum of acute coronary syndromes, including unstable angina, non-ST-elevation non-Q wave myocardial infarction, ST-elevation non-Q wave MI, and transmural (Q-wave) MI.
CA002412648A 2001-04-13 2002-04-11 Use of b-type natriuretic peptide as a prognostic indicator in acute coronary syndromes Expired - Lifetime CA2412648C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/835,298 2001-04-13
US09/835,298 US7632647B2 (en) 2001-04-13 2001-04-13 Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes
PCT/US2002/011441 WO2002083913A1 (en) 2001-04-13 2002-04-11 Use of b-type natriuretic peptide as a prognostic indicator in acute coronary syndromes

Publications (2)

Publication Number Publication Date
CA2412648A1 true CA2412648A1 (en) 2002-10-24
CA2412648C CA2412648C (en) 2008-10-21

Family

ID=25269150

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002412648A Expired - Lifetime CA2412648C (en) 2001-04-13 2002-04-11 Use of b-type natriuretic peptide as a prognostic indicator in acute coronary syndromes

Country Status (11)

Country Link
US (3) US7632647B2 (en)
EP (2) EP1983058B1 (en)
JP (2) JP3749225B2 (en)
AT (1) ATE402266T1 (en)
AU (2) AU2002252636B2 (en)
CA (1) CA2412648C (en)
DE (1) DE60227763D1 (en)
DK (1) DK1311701T3 (en)
ES (1) ES2310590T3 (en)
NZ (1) NZ523210A (en)
WO (1) WO2002083913A1 (en)

Families Citing this family (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6991907B1 (en) * 1995-04-18 2006-01-31 Biosite, Inc. Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
US6627404B1 (en) * 1995-04-18 2003-09-30 Biosite, Inc. Methods for improving the recovery of troponin I and T in membranes, filters and vessels
US20030199000A1 (en) * 2001-08-20 2003-10-23 Valkirs Gunars E. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US7632647B2 (en) 2001-04-13 2009-12-15 Biosite Incorporated Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes
US7524635B2 (en) * 2003-04-17 2009-04-28 Biosite Incorporated Methods and compositions for measuring natriuretic peptides and uses thereof
US20040253637A1 (en) * 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US20040176914A1 (en) * 2001-04-13 2004-09-09 Biosite Incorporated Methods and compositions for measuring biologically active natriuretic peptides and for improving their therapeutic potential
US20030219734A1 (en) * 2001-04-13 2003-11-27 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
WO2003016910A1 (en) * 2001-08-20 2003-02-27 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
DE60235416D1 (en) * 2001-05-04 2010-04-01 Biosite Inc Diagnostic markers of acute coronary syndromes and their uses
US20040219509A1 (en) * 2001-08-20 2004-11-04 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US7608406B2 (en) * 2001-08-20 2009-10-27 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US20040209307A1 (en) * 2001-08-20 2004-10-21 Biosite Incorporated Diagnostic markers of stroke and cerebral injury and methods of use thereof
US6461828B1 (en) 2001-09-04 2002-10-08 Syn X Pharma Conjunctive analysis of biological marker expression for diagnosing organ failure
MXPA03004105A (en) * 2002-05-14 2004-10-15 Hoffmann La Roche Making a prognosis in cases of cardiac disease using a combination of markers.
AU2003297583B2 (en) * 2002-11-26 2010-01-14 Biocon, Ltd Modified naturetic compounds, conjugates, and uses thereof
AU2003302340B8 (en) * 2002-12-24 2008-09-11 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
WO2004082639A2 (en) * 2003-03-19 2004-09-30 Baylor College Of Medicine Detecting coronary artery disease with bnp during stress testing
WO2004094460A2 (en) 2003-04-17 2004-11-04 Ciphergen Biosystems, Inc. Polypeptides related to natriuretic peptides and methods of their identification and use
WO2004097368A2 (en) * 2003-04-28 2004-11-11 Ciphergen Biosystems, Inc. Improved immunoassays
WO2004105575A2 (en) * 2003-05-29 2004-12-09 Trustee Of Darmouth College A method for detecting cardiac ischemia via changes in b-natriuretic peptide levels
US7632234B2 (en) * 2003-08-29 2009-12-15 Medtronic, Inc. Implantable biosensor devices for monitoring cardiac marker molecules
CA2537668A1 (en) * 2003-09-29 2005-04-14 Biosite Incorporated Methods and compositions for the diagnosis of sepsis
DE10355731A1 (en) 2003-11-28 2005-06-30 Roche Diagnostics Gmbh Analytical sandwich test to determine NT-proBNP
AU2004305066B2 (en) * 2003-12-18 2010-04-01 Abbott Rapid Diagnostics International Unlimited Company Monitoring method and apparatus
GB0329288D0 (en) 2003-12-18 2004-01-21 Inverness Medical Switzerland Monitoring method and apparatus
ES2311895T3 (en) * 2004-03-15 2009-02-16 F. Hoffmann-La Roche Ag THE USE OF BNP TYPE PEPTIDES AND ANF TYPE PEPTIDES TO ASSESS THE RISK OF PADDING A CARDIO-VASCULAR COMPLICATION AS A FREQUENCY OF OVERLOADING THE VOLUME.
US7223237B2 (en) * 2004-04-22 2007-05-29 Pacesetter, Inc. Implantable biosensor and methods for monitoring cardiac health
JP4838794B2 (en) * 2004-06-15 2011-12-14 エフ．ホフマン−ラ ロシュ アーゲー Use of cardiac hormones to diagnose the risk of suffering from cardiovascular complications as a result of cardiotoxic drugs
US20060024725A1 (en) * 2004-07-30 2006-02-02 Robert Hussa Oncofetal fibronectin as a marker for pregnancy-related indications
US20060084114A1 (en) * 2004-10-15 2006-04-20 Yeo Kiang-Tech J Method for detecting cardiac collateral formation
US20080207505A1 (en) * 2005-01-12 2008-08-28 James Kenneth D Bna Conjugates and Methods of Use
EP1691200A1 (en) * 2005-02-14 2006-08-16 F. Hoffmann-La Roche Ag The use of BNP-type peptides and ANP-type peptides for assessing the risk of suffering from a cardiovascular complication as a consequence of volume overload
US7432107B2 (en) * 2005-01-24 2008-10-07 Roche Diagnostics Operations, Inc. Cardiac hormones for assessing cardiovascular risk
PT1849009E (en) * 2005-01-24 2009-01-14 Hoffann La Roche Ag F The use of cardiac hormones for assessing a cardiovascular risk with respect to the administration of anti-inflammatory drugs.
US7731965B2 (en) * 2005-02-17 2010-06-08 Abbott Lab Human ring specific BNP antibodies
US7300494B2 (en) * 2005-02-24 2007-11-27 Hamilton Sundstrand Corporation On-board inert gas generation system with compressor surge protection
US7769451B2 (en) 2005-04-28 2010-08-03 Medtronic, Inc. Method and apparatus for optimizing cardiac resynchronization therapy
EP1722232A1 (en) * 2005-05-09 2006-11-15 F.Hoffmann-La Roche Ag Devices and methods for diagnosing or predicting early stage cardiac dysfunctions
ES2657087T3 (en) * 2005-07-29 2018-03-01 Koninklijke Philips N.V. Monitoring of cardiac natriuretic peptides during diagnosis, management and treatment of heart disease
US7939069B2 (en) 2005-11-09 2011-05-10 Abbott Laboratories Human BNP immunospecific antibodies
JP5364378B2 (en) * 2005-11-09 2013-12-11 アボット・ラボラトリーズ Human BNP immunospecific antibody
US20070224643A1 (en) * 2006-03-09 2007-09-27 Mcpherson Paul H Methods and compositions for the diagnosis of diseases of the aorta
EP1835289A1 (en) * 2006-03-13 2007-09-19 Roche Diagnostics GmbH Means and methods for predicting cardiovascular complications in subjects suffering from osteoporosis
ES2344993T3 (en) 2006-03-24 2010-09-13 F. Hoffmann-La Roche Ag MEANS AND METHODS FOR THE DIFFERENTIATION OF THE NECROSIS OF ACUTE AND CHRONIC MYOCARDIUM IN SYMPTOMATIC PATIENTS.
JP6325022B2 (en) * 2006-04-04 2018-05-16 シングレックス，インコーポレイテッド Sensitive system and method for the analysis of troponin
EP1845379A1 (en) 2006-04-13 2007-10-17 F. Hoffmann-La Roche AG Means and methods for the differentiation of cardiac and pulmonary causes of shortness of breath
US20080118924A1 (en) * 2006-05-26 2008-05-22 Buechler Kenneth F Use of natriuretic peptides as diagnostic and prognostic indicators in vascular diseases
EP1882945A1 (en) 2006-07-28 2008-01-30 F.Hoffmann-La Roche Ag Means and methods for the differentiation of cardiac and pulmonary causes of acute shortness of breath
BRPI0715126B8 (en) * 2006-08-04 2021-07-27 Medizinische Hochschule Hannover methods for risk assessment of cardiac interventions and gdf-15-based uses
EP1890153A1 (en) 2006-08-16 2008-02-20 F. Hoffman-la Roche AG Cardiac troponin as an indicator of advanced coronary artery disease
EP1890154B1 (en) * 2006-08-16 2012-07-04 F. Hoffmann-La Roche AG Cardiac troponin as an indicator of advanced coronary artery disease
US20080050749A1 (en) * 2006-08-17 2008-02-28 Ildiko Amann-Zalan Use of bnp-type peptides for the stratification of therapy with erythropoietic stimulating agents
ES2655564T3 (en) * 2006-09-07 2018-02-20 Otago Innovation Limited Biomarker for the early detection of acute heart disorders
US20080064045A1 (en) * 2006-09-07 2008-03-13 Huaiqin Wu Biomarker fragments for the detection of human BNP
EP1901072B1 (en) 2006-09-15 2009-11-25 F. Hoffman-la Roche AG Biochemical markers for acute pulmonary embolism
EP1901073A1 (en) 2006-09-18 2008-03-19 Roche Diagnostics GmbH Natriuretic peptides for diagnosing cardiac complications due to coronary catheterization
EP2095107B1 (en) 2006-11-14 2014-07-02 Alere San Diego, Inc. Methods for risk assignment
EP2095106B1 (en) * 2006-11-14 2013-03-20 Alere San Diego, Inc. Methods and compositions for diagnosis and prognosis of renal artery stenosis
EP1925943A1 (en) * 2006-11-21 2008-05-28 F. Hoffman-la Roche AG Means and methods for optimization of diagnostic and therapeutic approaches in chronic artery disease based on the detection of Troponin T and NT-proBNP.
WO2008061978A2 (en) * 2006-11-21 2008-05-29 Roche Diagnostics Gmbh Means and methods for optimization of diagnostic and therapeutic approaches in chronic artery disease based on the detection of troponin t and nt-probnp
JP2010515023A (en) * 2006-12-22 2010-05-06 アボット・ラボラトリーズ Cardiovascular autoimmune disease panel and method of use thereof
CA2671298C (en) 2007-01-25 2020-07-28 F. Hoffmann-La Roche Ag Use of igfbp-7 in the assessment of heart failure
EP2101178A1 (en) * 2008-03-12 2009-09-16 BRAHMS Aktiengesellschaft Use of Procalcitonin (PCT) in prognosis following acute coronary syndromes
DE602008021800C5 (en) 2007-08-03 2022-05-05 B.R.A.H.M.S Gmbh Antibiotic used to treat local infection
EP2031397A1 (en) 2007-08-30 2009-03-04 F. Hoffmann-La Roche AG Surfactant proteins B and D in differentiating the causes of shortness of breath
JP2011501113A (en) 2007-10-10 2011-01-06 エフ．ホフマン−ラ ロシュ アーゲー Natriuretic peptide / troponin ratio for assessment of preexisting myocardial dysfunction in patients with acute coronary syndrome
EP2103943A1 (en) 2008-03-20 2009-09-23 F. Hoffman-la Roche AG GDF-15 for assessing a cardiovascular risk with respect to the administration of antiinflammatory drugs
EP2294424A1 (en) 2008-05-21 2011-03-16 F. Hoffmann-La Roche AG L-fabp, natriuretic peptides and cardiac troponin in individuals in need for a cardiac therapy
EP2133696A1 (en) 2008-06-10 2009-12-16 Eberhardt Spanuth Very low concentrations of troponin I or T for assessing a cardiovascular risk with respect to the administration of anti-inflammatory drugs
JP2011523072A (en) * 2008-06-13 2011-08-04 エフ．ホフマン−ラ ロシュ アーゲー Evaluation of complications in patients with type 1 diabetes
WO2010007041A1 (en) * 2008-07-14 2010-01-21 Roche Diagnostics Gmbh Multimarker panel for diagnosing, monitoring and selecting the therapy for patients with heart failure
ES2644723T3 (en) 2008-07-23 2017-11-30 F. Hoffmann-La Roche Ag Identification of subjects susceptible to antiangiogenic treatment
WO2010017972A1 (en) 2008-08-13 2010-02-18 Roche Diagnostics Gmbh D-dimer, troponin, nt-probnp for pulmonary embolism
DK2425016T3 (en) 2009-04-29 2015-06-29 Amc Amsterdam MEANS AND METHODS TO REMEDY THE, PREVENT AND / OR diagnose heart failure or EN risk of cardiac failure
JP5717108B2 (en) 2009-09-17 2015-05-13 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Multi-marker panel for left ventricular hypertrophy
CN102812359A (en) * 2009-11-13 2012-12-05 Bg医药公司 Risk Factors And Prediction Of Myocardial Infarction
EP3246708A3 (en) 2009-12-18 2018-01-03 Roche Diagnostics GmbH Troponins for predicting kidney failure in heart surgery patients
CZ2009872A3 (en) * 2009-12-22 2011-04-20 Ústav informatiky AV CR, v.v.i. Centrum biomedicínské informatiky Method of determining prognosis of patients with primary myocardial infarction and oligonucleotide chip for such determination
EP2533653B1 (en) 2010-02-12 2015-01-28 Synlab Medizinisches Versorgungszentrum Heidelberg GmbH Homoarginine as a biomarker for the risk of mortality
EP2388594A1 (en) 2010-05-17 2011-11-23 Roche Diagnostics GmbH GDF-15 based means and methods for survival and recovery prediction in acute inflammation
WO2012020045A1 (en) 2010-08-10 2012-02-16 Roche Diagnostics Gmbh Method for selecting patients with stable coronary artery disease for pci or medical treatment
EP2367006A1 (en) 2010-08-24 2011-09-21 Roche Diagnostics GmbH PLGF-based means and methods for diagnosing cardiac causes in acute inflammation
EP2796874B1 (en) 2010-08-26 2017-03-08 Roche Diagnostics GmbH Use of biomarkers in monitoring a medication in a subject suffering from heart failure
EP2439535A1 (en) 2010-10-07 2012-04-11 F. Hoffmann-La Roche AG Diagnosis of diabetes related heart disease and GDF-15 and Troponin as predictors for the development of type 2 diabetes mellitus
EP2447720A1 (en) 2010-10-26 2012-05-02 Roche Diagnostics GmbH sFlt1 and pulmonary complications
EP2383579A1 (en) 2010-12-17 2011-11-02 F. Hoffmann-La Roche AG sFlt-1, cardiac troponins and natriuretic peptides in the recognition of therapy with HER-2 inhibitors
CN102103143B (en) * 2011-02-24 2013-09-25 南京基蛋生物科技有限公司 Colloidal gold test strip for double-index detection and preparation method thereof
EP2385373A1 (en) 2011-07-01 2011-11-09 F. Hoffmann-La Roche AG Natriuretic peptides in pregnancy
EP2581040A1 (en) 2011-10-10 2013-04-17 Roche Diagnostics GmbH TnT based cardiac hypertrophy risk related physiological training and guidance in athletes
EP2769227B1 (en) 2011-10-17 2016-07-27 Roche Diagnostics GmbH Troponin and bnp based diagnosis of risk patients and cause of stroke
CA2856461C (en) 2011-12-01 2020-08-18 F. Hoffmann-La Roche Ag Nt-proanp and nt-probnp for the diagnosis of stroke
EP2620773B1 (en) 2012-01-26 2015-03-18 Roche Diagniostics GmbH Method for the differentiation of forward and backward heart failure
EP2650684A1 (en) 2012-04-10 2013-10-16 Roche Diagniostics GmbH Pro SP-B and NT-proBNP based diagnosis in patients with pneumonia
EP2615459A1 (en) 2012-04-27 2013-07-17 Roche Diagniostics GmbH proSP-B based diagnosis of distal airway involvement in asthma
EP2600155A1 (en) 2012-06-18 2013-06-05 Roche Diagniostics GmbH sFlt-1 based diagnosis and monitoring of stroke patients
EP2597467A1 (en) 2012-06-26 2013-05-29 Roche Diagniostics GmbH Means and methods for proSP-B based diagnosis of pulmonary congestion in ACS patients
EP2597466A1 (en) 2012-06-26 2013-05-29 Roche Diagniostics GmbH Means and methods for proSP-B based diagnosis of alveolar damage in pulmonary hypertension patients
WO2014009418A1 (en) 2012-07-10 2014-01-16 Roche Diagnostics Gmbh TnT, NTproBNP, sFlt-1 for CURB65 IN PNEUMONIA
CA2883890C (en) 2012-09-12 2021-11-09 Dirk Block Identification of patients with abnormal fractional shortening
US20140273273A1 (en) 2012-11-01 2014-09-18 Christie Mitchell Ballantyne Biomarkers to improve prediction of heart failure risk
EP2730923A1 (en) 2012-11-09 2014-05-14 Roche Diagniostics GmbH NTproBNP and cTnT based therapy guidance in heart failure
CN104769436B (en) 2012-11-09 2018-01-26 霍夫曼-拉罗奇有限公司 The diagnosis based on TnT of paroxysmal atrial fibrillation
EP3399315A3 (en) 2012-12-04 2019-01-02 Roche Diagnostics GmbH Biomarkers in the selection of therapy of heart failure
EP2866033A1 (en) 2013-10-23 2015-04-29 Roche Diagniostics GmbH Differential diagnosis of acute dyspnea based on C-terminal proSP-B, KL-6 and BNP-type peptides
WO2015063248A2 (en) 2013-11-04 2015-05-07 F. Hoffmann-La Roche Ag Biomarkers and methods for progression prediction for chronic kidney disease
CN106461636A (en) * 2014-01-10 2017-02-22 重症监护诊断股份有限公司 Methods and systems for determining risk of heart failure
EP2899544B1 (en) 2014-01-28 2018-12-26 Roche Diagnostics GmbH Biomarkers for risk assessment and treatment monitoring in heart failure patients who receive B-type natriuretic peptide guided therapy
EP2916134B1 (en) 2014-03-05 2017-08-16 Roche Diagnostics GmbH Use of Seprase for differential diagnosis of acute dyspnea
EP2924438B1 (en) 2014-03-26 2018-04-18 Roche Diagnostics GmbH IGFBP7 for diagnosing diastolic dysfunction
CA2961340C (en) 2014-09-26 2023-10-17 Somalogic, Inc. Cardiovascular risk event prediction and uses thereof
EP3411721A1 (en) 2016-02-04 2018-12-12 Metanomics GmbH Means and methods for differentiating between heart failure and pulmonary disease in a subject
EP3279665B1 (en) 2016-08-04 2020-07-08 Roche Diagniostics GmbH Circulating esm-1 (endocan) in the assessment of atrial fibrillation
WO2018069487A1 (en) 2016-10-14 2018-04-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for predicting the risk of loss of renal function in patients with type 2 diabetes
WO2018127372A1 (en) 2016-12-13 2018-07-12 Witteman Johanna Cornelia Maria Detection of transient troponin peaks for diagnosis of subjects at high risk of cardiovascular disease
EP3360570A1 (en) 2017-02-13 2018-08-15 Roche Diagnostics GmbH Antibodies recognizing genetic variants
JP6985517B2 (en) * 2017-09-30 2021-12-22 アルフレッド ヘルス Prognosis prediction method
WO2020025689A1 (en) 2018-07-31 2020-02-06 F. Hoffmann-La Roche Ag Circulating dkk3 (dickkopf-related protein 3) in the assessment of atrial fibrillation
KR20210044216A (en) 2018-08-10 2021-04-22 에프. 호프만-라 로슈 아게 CES-2 (carboxylesterase-2) for evaluation of atrial fibrillation-related stroke
JP2021535370A (en) 2018-08-16 2021-12-16 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Circulating TFPI-2 (tissue factor pathway inhibitor 2) in the evaluation of atrial fibrillation and anticoagulant therapy
EP3837550A1 (en) 2018-08-17 2021-06-23 Roche Diagnostics GmbH Circulating bmp10 (bone morphogenic protein 10) in the assessment of atrial fibrillation
KR20210047304A (en) 2018-08-22 2021-04-29 에프. 호프만-라 로슈 아게 Cyclic SPON-1 (spondin-1) in atrial fibrillation assessment
CN113396331A (en) 2018-08-24 2021-09-14 豪夫迈·罗氏有限公司 Circulating FGFBP-1 (fibroblast growth factor binding protein 1) in the assessment of atrial fibrillation and for stroke prediction
WO2020064995A1 (en) 2018-09-28 2020-04-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of biomarkers representing cardiac, vascular and inflammatory pathways for the prediction of acute kidney injury in patients with type 2 diabetes
US11931207B2 (en) 2018-12-11 2024-03-19 Eko.Ai Pte. Ltd. Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device
US11446009B2 (en) 2018-12-11 2022-09-20 Eko.Ai Pte. Ltd. Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images
WO2020234451A1 (en) 2019-05-23 2020-11-26 Roche Diagnostics Gmbh IGFBP7 RATIO FOR HFpEF
JP2023515436A (en) 2020-02-20 2023-04-13 ユニベルシテイト マーストリヒト Method for detecting circulating BMP10 (bone morphogenetic protein 10)
US11419917B2 (en) 2020-04-07 2022-08-23 Drora Shevy Treatment for SARS-CoV-2 and other coronaviruses
US20230366894A1 (en) 2020-09-30 2023-11-16 Roche Diagnostics Operations, Inc. Circulating total-nt-probnp (glycosylated and unglycosylated nt-probnp) and its ratio with nt-probnp (unglycosylated nt-probnp) in the assessment of atrial fibrillation
CN112710852B (en) * 2021-03-26 2021-08-03 上海美迪西生物医药股份有限公司 GNP polypeptide detection kit and detection method
WO2023175152A1 (en) 2022-03-18 2023-09-21 Roche Diagnostics Gmbh Troponin marker combinations for early discrimination of type 2 versus type 1 acute myocardial infarction
WO2023175176A1 (en) 2022-03-18 2023-09-21 Roche Diagnostics Gmbh Cmybpc marker combinations for early discrimination of type 2 versus type 1 acute myocardial infarction

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5292636A (en) * 1986-03-31 1994-03-08 T Cell Diagnostics, Inc. Therapeutic and diagnostic methods using soluble T cell surface molecules
US5382522A (en) * 1987-07-21 1995-01-17 International Immunoassay Laboratories, Inc. Immunoassay for creatine kinase-MB and creatine kinase-BB isoforms and reagents
US5382515A (en) * 1987-07-21 1995-01-17 International Immunoassay Laboratories, Inc. Creative kinase-MB immunoassay for myocardial infarction and reagents
US4900662A (en) * 1987-07-21 1990-02-13 International Immunoassay Laboratories, Inc. CK-MM myocardial infarction immunoassay
US5453359A (en) * 1988-06-13 1995-09-26 American Biogenetic Sciences, Inc. Immunoassay and kit for in vitro detection of soluble DesAABB fibrin polymers
US5206140A (en) 1988-06-24 1993-04-27 Research Corporation Technologies, Inc. Assay for soluble crosslinked fibrin polymers
US5422393A (en) 1988-07-11 1995-06-06 Naturon Pharmaceutical Corporation Natriuretic hormone
US5939272A (en) 1989-01-10 1999-08-17 Biosite Diagnostics Incorporated Non-competitive threshold ligand-receptor assays
US5028535A (en) 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay
JP3394040B2 (en) 1989-06-23 2003-04-07 ジェネンテック・インコーポレーテッド Compositions and methods of synthesis and use of natriuretic protein receptor B
US5580722A (en) 1989-07-18 1996-12-03 Oncogene Science, Inc. Methods of determining chemicals that modulate transcriptionally expression of genes associated with cardiovascular disease
SE8904407L (en) 1989-12-29 1991-06-30 Qingpingfeng MEDICATION FOR TREATMENT OF HEART FAILURE
US5922615A (en) 1990-03-12 1999-07-13 Biosite Diagnostics Incorporated Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network
WO1992005282A1 (en) 1990-09-14 1992-04-02 Biosite Diagnostics, Inc. Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays
US5710008B1 (en) * 1990-10-12 1999-09-07 Spectral Diagnostics Inc Method and device for diagnosing and distinguishing chest pain in early onset thereof
US5604105B1 (en) 1990-10-12 1999-08-24 Spectral Diagnostics Inc Method and device for diagnosingand distinguishing chest pain in early onset thereof
CA2027434C (en) * 1990-10-12 1999-01-05 George Jackowski Diagnostic kit for diagnosing and distinguishing chest pain in early onset thereof
US5955377A (en) 1991-02-11 1999-09-21 Biostar, Inc. Methods and kits for the amplification of thin film based assays
JPH06506688A (en) 1991-04-10 1994-07-28 バイオサイト・ダイアグノスティックス・インコーポレイテッド Crosstalk inhibitors and their use
EP0579767B1 (en) 1991-04-11 2000-08-23 Biosite Diagnostics Inc. Novel conjugates and assays for simultaneous detection of multiple ligands
US5885527A (en) 1992-05-21 1999-03-23 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membrances
US6143576A (en) 1992-05-21 2000-11-07 Biosite Diagnostics, Inc. Non-porous diagnostic devices for the controlled movement of reagents
GB9211686D0 (en) 1992-06-03 1992-07-15 Medisinsk Innovation A S Chemical compounds
US5494829A (en) 1992-07-31 1996-02-27 Biostar, Inc. Devices and methods for detection of an analyte based upon light interference
US6147688A (en) 1993-06-28 2000-11-14 Athena Design Systems, Inc. Method and apparatus for defining and selectively repeating unit image cells
US5824799A (en) 1993-09-24 1998-10-20 Biosite Diagnostics Incorporated Hybrid phthalocyanine derivatives and their uses
EP0687120A1 (en) * 1994-06-09 1995-12-13 ALCATEL BELL Naamloze Vennootschap Policing method guaranteeing fair throughput and device realizing such a method
US6627404B1 (en) * 1995-04-18 2003-09-30 Biosite, Inc. Methods for improving the recovery of troponin I and T in membranes, filters and vessels
US5795725A (en) 1995-04-18 1998-08-18 Biosite Diagnostics Incorporated Methods for the assay of troponin I and T and selection of antibodies for use in immunoassays
US6991907B1 (en) * 1995-04-18 2006-01-31 Biosite, Inc. Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
US6174686B1 (en) * 1995-04-18 2001-01-16 Biosite Diagnostics, Inc. Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
CA2248140C (en) * 1996-03-04 2005-02-01 Ronald P. Mischak Assay and reagents for quantifying hbnp
US5768163A (en) * 1996-04-15 1998-06-16 Hewlett-Packard Versatile attachment of handheld devices to a host computing system
US6113855A (en) 1996-11-15 2000-09-05 Biosite Diagnostics, Inc. Devices comprising multiple capillarity inducing surfaces
US6156521A (en) 1997-12-19 2000-12-05 Biosite Diagnostics, Inc. Methods for the recovery and measurement of troponin complexes
US5947124A (en) 1997-03-11 1999-09-07 Biosite Diagnostics Incorporated Diagnostic for determining the time of a heart attack
US6828107B2 (en) * 1997-09-11 2004-12-07 Shionogi & Co., Ltd. Immunoassay method for BNP
US6117644A (en) 1998-06-04 2000-09-12 Ottawa Heart Institute Research Corporation Predicting and detecting cardiac allograft rejection
US6171870B1 (en) * 1998-08-06 2001-01-09 Spectral Diagnostics, Inc. Analytical test device and method for use in medical diagnoses
US6309888B1 (en) 1998-09-04 2001-10-30 Leuven Research & Development Vzw Detection and determination of the stages of coronary artery disease
DE19847690A1 (en) 1998-10-15 2000-04-20 Brahms Diagnostica Gmbh Diagnosing sepsis and severe infections, useful for assessing severity and progress of treatment, by measuring content of peptide prohormone or their derived fragments
US6743595B1 (en) * 1999-01-25 2004-06-01 Metriogene Biosciences Inc. Method and diagnostic kit for diagnosis of endometriosis
US6670138B2 (en) 2000-11-01 2003-12-30 Agy Therapeutics, Inc. Method of diagnosing ischemic stroke via UCP-2 detection
US20040126767A1 (en) * 2002-12-27 2004-07-01 Biosite Incorporated Method and system for disease detection using marker combinations
US20040203083A1 (en) * 2001-04-13 2004-10-14 Biosite, Inc. Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases
US20040176914A1 (en) * 2001-04-13 2004-09-09 Biosite Incorporated Methods and compositions for measuring biologically active natriuretic peptides and for improving their therapeutic potential
WO2003016910A1 (en) * 2001-08-20 2003-02-27 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US7632647B2 (en) * 2001-04-13 2009-12-15 Biosite Incorporated Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes
US20040253637A1 (en) * 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US7524635B2 (en) * 2003-04-17 2009-04-28 Biosite Incorporated Methods and compositions for measuring natriuretic peptides and uses thereof
US20030219734A1 (en) * 2001-04-13 2003-11-27 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
US20040121350A1 (en) * 2002-12-24 2004-06-24 Biosite Incorporated System and method for identifying a panel of indicators
US20030199000A1 (en) * 2001-08-20 2003-10-23 Valkirs Gunars E. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
DE60235416D1 (en) * 2001-05-04 2010-04-01 Biosite Inc Diagnostic markers of acute coronary syndromes and their uses
US6627457B2 (en) 2001-07-30 2003-09-30 Quest Diagnostics Investments Incorporated Methods for detecting pregnancy
US20040209307A1 (en) * 2001-08-20 2004-10-21 Biosite Incorporated Diagnostic markers of stroke and cerebral injury and methods of use thereof
US20040219509A1 (en) * 2001-08-20 2004-11-04 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US7608406B2 (en) * 2001-08-20 2009-10-27 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US6461828B1 (en) 2001-09-04 2002-10-08 Syn X Pharma Conjunctive analysis of biological marker expression for diagnosing organ failure
WO2004094460A2 (en) * 2003-04-17 2004-11-04 Ciphergen Biosystems, Inc. Polypeptides related to natriuretic peptides and methods of their identification and use
US20060105419A1 (en) * 2004-08-16 2006-05-18 Biosite, Inc. Use of a glutathione peroxidase 1 as a marker in cardiovascular conditions
EP1794588A2 (en) * 2004-09-09 2007-06-13 Biosite Incorporated Methods and compositions for measuring canine bnp and uses thereof
WO2006078813A2 (en) * 2005-01-21 2006-07-27 Biosite Incorporated Arginine analogs, and methods for their synthesis and use
CA2610910A1 (en) * 2005-06-09 2006-12-21 Paul H. Mcpherson Methods and compositions for the diagnosis of venous thromboembolic disease
WO2007028070A2 (en) * 2005-08-30 2007-03-08 Biosite, Inc. Use of soluble flt-1 and its fragments in cardiovascular conditions
US20070224643A1 (en) * 2006-03-09 2007-09-27 Mcpherson Paul H Methods and compositions for the diagnosis of diseases of the aorta
US20080118924A1 (en) * 2006-05-26 2008-05-22 Buechler Kenneth F Use of natriuretic peptides as diagnostic and prognostic indicators in vascular diseases
EP2095106B1 (en) * 2006-11-14 2013-03-20 Alere San Diego, Inc. Methods and compositions for diagnosis and prognosis of renal artery stenosis
EP2095107B1 (en) * 2006-11-14 2014-07-02 Alere San Diego, Inc. Methods for risk assignment

Also Published As

Publication number Publication date
NZ523210A (en) 2007-04-27
US20110065210A1 (en) 2011-03-17
AU2002252636B2 (en) 2007-03-08
EP1983058A1 (en) 2008-10-22
US7632647B2 (en) 2009-12-15
ATE402266T1 (en) 2008-08-15
EP1311701A1 (en) 2003-05-21
AU2007201180A1 (en) 2007-04-19
AU2007201180B2 (en) 2010-11-25
JP2004519688A (en) 2004-07-02
JP4119408B2 (en) 2008-07-16
CA2412648C (en) 2008-10-21
US20030022235A1 (en) 2003-01-30
WO2002083913A1 (en) 2002-10-24
JP2005049351A (en) 2005-02-24
JP3749225B2 (en) 2006-02-22
EP1311701A4 (en) 2005-11-09
DE60227763D1 (en) 2008-09-04
ES2310590T3 (en) 2009-01-16
EP1983058B1 (en) 2013-12-18
US20040171064A1 (en) 2004-09-02
EP1311701B1 (en) 2008-07-23
DK1311701T3 (en) 2008-11-03

Similar Documents

Publication Publication Date Title
CA2412648A1 (en) Use of b-type natriuretic peptide as a prognostic indicator in acute coronary syndromes
CA2315186A1 (en) Methods for the recovery and measurement of troponin complexes
EP0846776A3 (en) Devices and methods for detecting multiple analytes in samples
NO20002844D0 (en) Improved electrochemical biosensor test strip
DE69731626D1 (en) SH3-BINDING PEPTIDES OF CORTACTIN AND THEIR USE
WO2002089657A3 (en) Diagnostic markers of acute coronary syndromes and methods of use thereof
EP2083015A3 (en) Biosensor compositions and methods of use
EP1482313A4 (en) Capacity load type probe, and test jig using the same
EP0982586A3 (en) Carbon monoxide sensor, method for making the same, and method of using the same
EP1426838A3 (en) Timepiece
AU6415000A (en) Indicator peptide for diagnosing and/or predicting cardiovascular and/or endothelial diseases, antibody composition and immunoassay
GB0315291D0 (en) Assay
WO2003081253A3 (en) Electrochemical multi-well plate
WO2003056344A3 (en) Protein analysis using mass spectrometry
EP2071338A3 (en) Human diabetes-mediating proteins
GB2339281A8 (en) Immunoassay test strip
WO2002059600A3 (en) Analyte detection
DE69803650T2 (en) Gas analysis facility
CA2329818A1 (en) Method for analyzing total reactive sulfur
DE69916223D1 (en) Redistribution of silalkylenes into an alkyl-rich silalkylene-containing residue
DE60111525D1 (en) PEPTIDE POTENTIATION OF ACID SENSORY ION CHANNELS ON PAIN
ZA200100234B (en) Immunoassay testing kit and containers.
WO2003089899A3 (en) Probes for detecting tumor cells
CA2428319A1 (en) Compositions and methods for diagnosing or treating psoriasis
WO2002031127A3 (en) Cloning and recombinant expression of mammalian group xii secreted phospholipase a¿2?

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20220411