CA2422884A1 - In situ bioprosthetic filler and methods, particularly for the in situ formation of vertebral disc bioprosthetics - Google Patents
In situ bioprosthetic filler and methods, particularly for the in situ formation of vertebral disc bioprosthetics Download PDFInfo
- Publication number
- CA2422884A1 CA2422884A1 CA002422884A CA2422884A CA2422884A1 CA 2422884 A1 CA2422884 A1 CA 2422884A1 CA 002422884 A CA002422884 A CA 002422884A CA 2422884 A CA2422884 A CA 2422884A CA 2422884 A1 CA2422884 A1 CA 2422884A1
- Authority
- CA
- Canada
- Prior art keywords
- cavity
- bioprosthetic
- situ
- biopolymer
- vertebral disc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/3654—Cartilage, e.g. meniscus
- A61L27/3658—Intervertebral discs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
- A61F2002/4445—Means for culturing intervertebral disc tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
- A61F2002/445—Intervertebral disc tissue harvest sites
Abstract
Bioprosthetic devices (10) include an exterior biological tissue member (10-1) which at least partly defines a cavity, and a proteinaceous biopolymer (10-2) which fills the cavity, and intercalates and is chemically bound (fixed) to the tissue of the surrounding biological tissue member. In preferred forms, the bioprosthetic device (10) is a bioprosthetic vertebral disc, having a fibrillar outer annulus which surrounds and defines an interior cavity and is formed by removal of at least a substantial portion of the natural gelatinous core therefrom. The cavity defined by the fibrillar outer annulus may then be filled with a flowable proteinaceous biopolymer (10-2). Preferably, the proteinaceous biopolymer (10-2) is a liquid mixture comprised of human or animal-derived protein material and a di- or polyaldehyde, which are allowed to react in situ to form a cross-linked biopolymer within the cavity. The liquid mixture may be formed in advance of being introduced into the cavity, or may be formed simultaneously during introduction into the cavity.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24245700P | 2000-10-24 | 2000-10-24 | |
US60/242,457 | 2000-10-24 | ||
PCT/US2001/032632 WO2002034111A2 (en) | 2000-10-24 | 2001-10-24 | In situ bioprosthetic filler and methods, particularly for the in situ formation of vertebral disc bioprosthetics |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2422884A1 true CA2422884A1 (en) | 2002-05-02 |
CA2422884C CA2422884C (en) | 2009-05-19 |
Family
ID=22914850
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002422884A Expired - Fee Related CA2422884C (en) | 2000-10-24 | 2001-10-24 | In situ bioprosthetic filler and methods, particularly for the in situ formation of vertebral disc bioprosthetics |
Country Status (9)
Country | Link |
---|---|
US (4) | US20020049498A1 (en) |
EP (1) | EP1328220B1 (en) |
JP (1) | JP4202749B2 (en) |
AT (1) | ATE494014T1 (en) |
AU (2) | AU2002215387B2 (en) |
CA (1) | CA2422884C (en) |
DE (1) | DE60143804D1 (en) |
ES (1) | ES2358498T3 (en) |
WO (1) | WO2002034111A2 (en) |
Families Citing this family (101)
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US7998213B2 (en) | 1999-08-18 | 2011-08-16 | Intrinsic Therapeutics, Inc. | Intervertebral disc herniation repair |
US6821276B2 (en) * | 1999-08-18 | 2004-11-23 | Intrinsic Therapeutics, Inc. | Intervertebral diagnostic and manipulation device |
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JP4247519B2 (en) * | 1999-08-18 | 2009-04-02 | イントリンジック セラピューティックス インコーポレイテッド | Apparatus and method for nucleus augmentation and retention |
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US7507243B2 (en) * | 1999-08-18 | 2009-03-24 | Gregory Lambrecht | Devices and method for augmenting a vertebral disc |
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-
2001
- 2001-10-24 EP EP01984004A patent/EP1328220B1/en not_active Expired - Lifetime
- 2001-10-24 AU AU2002215387A patent/AU2002215387B2/en not_active Ceased
- 2001-10-24 WO PCT/US2001/032632 patent/WO2002034111A2/en active IP Right Grant
- 2001-10-24 US US09/983,537 patent/US20020049498A1/en not_active Abandoned
- 2001-10-24 DE DE60143804T patent/DE60143804D1/en not_active Expired - Lifetime
- 2001-10-24 CA CA002422884A patent/CA2422884C/en not_active Expired - Fee Related
- 2001-10-24 JP JP2002537171A patent/JP4202749B2/en not_active Expired - Fee Related
- 2001-10-24 ES ES01984004T patent/ES2358498T3/en not_active Expired - Lifetime
- 2001-10-24 AU AU1538702A patent/AU1538702A/en active Pending
- 2001-10-24 AT AT01984004T patent/ATE494014T1/en active
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2004
- 2004-12-10 US US11/008,609 patent/US7621959B2/en not_active Expired - Fee Related
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2006
- 2006-12-08 US US11/635,928 patent/US7621954B2/en not_active Expired - Fee Related
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2007
- 2007-10-31 US US11/932,066 patent/US7896920B2/en not_active Expired - Fee Related
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ES2358498T3 (en) | 2011-05-11 |
WO2002034111A3 (en) | 2003-01-16 |
US20020049498A1 (en) | 2002-04-25 |
US7621959B2 (en) | 2009-11-24 |
WO2002034111A2 (en) | 2002-05-02 |
ATE494014T1 (en) | 2011-01-15 |
JP4202749B2 (en) | 2008-12-24 |
US7621954B2 (en) | 2009-11-24 |
US20070093902A1 (en) | 2007-04-26 |
US20080058942A1 (en) | 2008-03-06 |
JP2004532656A (en) | 2004-10-28 |
US7896920B2 (en) | 2011-03-01 |
EP1328220B1 (en) | 2011-01-05 |
AU2002215387B2 (en) | 2005-09-29 |
US20050102030A1 (en) | 2005-05-12 |
EP1328220A2 (en) | 2003-07-23 |
CA2422884C (en) | 2009-05-19 |
EP1328220A4 (en) | 2009-08-19 |
DE60143804D1 (en) | 2011-02-17 |
AU1538702A (en) | 2002-05-06 |
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