CA2425312A1 - Microprotrusion member retainer for impact applicator - Google Patents

Microprotrusion member retainer for impact applicator Download PDF

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Publication number
CA2425312A1
CA2425312A1 CA002425312A CA2425312A CA2425312A1 CA 2425312 A1 CA2425312 A1 CA 2425312A1 CA 002425312 A CA002425312 A CA 002425312A CA 2425312 A CA2425312 A CA 2425312A CA 2425312 A1 CA2425312 A1 CA 2425312A1
Authority
CA
Canada
Prior art keywords
assembly
retainer
microprotrusion member
stratum corneum
microprotrusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002425312A
Other languages
French (fr)
Other versions
CA2425312C (en
Inventor
Joseph C. Trautman
Richard L. Keenan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corporation
Joseph C. Trautman
Richard L. Keenan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corporation, Joseph C. Trautman, Richard L. Keenan filed Critical Alza Corporation
Publication of CA2425312A1 publication Critical patent/CA2425312A1/en
Application granted granted Critical
Publication of CA2425312C publication Critical patent/CA2425312C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles

Abstract

A retainer (34) is provided for holding a microprotrusion member (44) for application of the microprotrusion member (44) to the stratum corneum with an impact applicator (10). The microprotrusion member (44) includes a plurality of microprotrusions (90) which penetrate the stratum corneum to improve transport of an agent across the stratum corneum.

Claims (27)

1. An assembly for use in a stratum-corneum piercing drug delivery system comprising:
a microprotrusion member having a plurality of stratum corneum piercing microprotrusions thereon and being adapted for piercing the stratum corneum to improve transdermal agent flux; and a retainer which is releasably attached to said microprotrusion member and wherein said retainer is adapted to be attached to an impacting device.
2. The assembly of claim 1 wherein said retainer is adapted to be releasably attached to an impacting device.
3. The assembly of claim 1, wherein the retainer substantially surrounds said microprotrusion member and substantially prevents contact between the microprotrusion member and the stratum corneum prior to piercing.
4. The assembly of claim 1, wherein the retainer has a central axis and the impact is applied substantially parallel to said axis.
5. The assembly of claim 4, wherein the microprotrusion member is positioned in a plane substantially perpendicular to the central axis of the retainer.
6. The assembly of claim 1, wherein the microprotrusions have a length of less than 500 µm.
7. The assembly of claim 1, wherein the microprotrusion member includes an adhesive for securing the member to the stratum corneum.
8. The assembly of claim 1, wherein the microprotrusion member is positioned in the retainer by a releasable connection selected from the group consisting of adhering a portion of the microprotrusion member to the retainer, a frangible connection, a friction fit, and a press-in securing member.
9. The assembly of claim 1, wherein the microprotrusion member includes a central section having microprotrusions thereon, an adhesive section surrounding the central section, a frangible section surrounding the adhesive section, and an outer portion surrounding the frangible section attached to the retainer.
10. The assembly of claim 1, wherein the retainer is ring shaped.
11. The assembly of claim 1, wherein said retainer further includes a first and a second end; said microprotrusion member being positioned between said first and said second ends of said retainer and spaced from said first and said second ends of said retainer.
12. The assembly of claim 11, further including peelable seals covering said first and said second ends of said retainer.
13. The assembly of claim 12, wherein said retainer further comprises a socket adapted to be releasably mounted on an impacting device.
14. The assembly of claim 13, wherein said socket is circular.
15. The assembly of claim 1, wherein the microprotrusion member comprises a patch having an array of microprotrusions.
16. The assembly of claim 15, wherein said patch further includes an agent-containing reservoir.
17. The assembly of claim 15, wherein said patch further includes an adhesive for securing the patch to the stratum corneum.
18. The assembly of claim 16, wherein the agent is a drug or a vaccine.
19. The assembly of claim 15, wherein the patch includes an agent-receiving reservoir.
20. The assembly of claim 19, wherein the agent-receiving reservoir is adapted to receive a body analyte.
21. The assembly of claim 1, further including a package surrounding said microprotrusion member and said retainer.
22. The assembly of claim 21, wherein said package is sealed.
23. The assembly of claim 21, wherein said package is sterile.
24. A method of applying a microprotrusion member to the stratum corneum to facilitate transdermal delivery or sampling of an agent, the method comprising:
providing a retainer holding a microprotrusion member in a sealed package;
opening said package;
attaching the retainer to an impact applicator; and applying the microprotrusion member to the stratum corneum with the impact applicator.
25. The method of claim 24, including the step of removing said retainer and said microprotrusion member from said package before said applying step.
26. The method of claim 24, wherein said retainer is ring-shaped.
27. The method of claim 24, wherein said retainer is ring-shaped.
CA2425312A 2000-10-13 2001-10-12 Microprotrusion member retainer for impact applicator Expired - Fee Related CA2425312C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24037900P 2000-10-13 2000-10-13
US60/240,379 2000-10-13
PCT/US2001/031837 WO2002030300A2 (en) 2000-10-13 2001-10-12 Microprotrusion member retainer for impact applicator

Publications (2)

Publication Number Publication Date
CA2425312A1 true CA2425312A1 (en) 2002-04-18
CA2425312C CA2425312C (en) 2010-02-16

Family

ID=22906291

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2425312A Expired - Fee Related CA2425312C (en) 2000-10-13 2001-10-12 Microprotrusion member retainer for impact applicator

Country Status (25)

Country Link
US (3) US6855131B2 (en)
EP (1) EP1341452B1 (en)
JP (1) JP4104975B2 (en)
KR (1) KR20030068137A (en)
CN (1) CN1479589A (en)
AT (1) ATE416692T1 (en)
AU (2) AU2001296817B2 (en)
BR (1) BR0114628A (en)
CA (1) CA2425312C (en)
CZ (1) CZ20031302A3 (en)
DE (1) DE60136951D1 (en)
DK (1) DK1341452T3 (en)
ES (1) ES2317940T3 (en)
HK (1) HK1058890A1 (en)
HU (1) HUP0303576A2 (en)
IL (1) IL155389A0 (en)
MA (1) MA26058A1 (en)
MX (1) MXPA03003303A (en)
NO (1) NO20031680L (en)
NZ (1) NZ525295A (en)
PL (1) PL360977A1 (en)
PT (1) PT1341452E (en)
RU (1) RU2278623C2 (en)
WO (1) WO2002030300A2 (en)
ZA (1) ZA200303631B (en)

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US10828480B2 (en) 2015-09-02 2020-11-10 Hisamitsu Pharmaceutical Co., Inc. Applicator

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