CA2429228A1 - Improved sucralose composition and process for the crystallization thereof - Google Patents

Improved sucralose composition and process for the crystallization thereof Download PDF

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Publication number
CA2429228A1
CA2429228A1 CA002429228A CA2429228A CA2429228A1 CA 2429228 A1 CA2429228 A1 CA 2429228A1 CA 002429228 A CA002429228 A CA 002429228A CA 2429228 A CA2429228 A CA 2429228A CA 2429228 A1 CA2429228 A1 CA 2429228A1
Authority
CA
Canada
Prior art keywords
sucralose
crystallization
sucralose composition
disclosed
range
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002429228A
Other languages
French (fr)
Other versions
CA2429228C (en
Inventor
Fiesal El Kabbani
Steven J. Catani
Christian Heiss
Juan Navia
Amal Brohmi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tate and Lyle PLC
Original Assignee
Mcneil-Ppc, Inc.
Fiesal El Kabbani
Steven J. Catani
Christian Heiss
Juan Navia
Amal Brohmi
Tate & Lyle Public Limited Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mcneil-Ppc, Inc., Fiesal El Kabbani, Steven J. Catani, Christian Heiss, Juan Navia, Amal Brohmi, Tate & Lyle Public Limited Company filed Critical Mcneil-Ppc, Inc.
Priority to CA2604326A priority Critical patent/CA2604326C/en
Priority to CA2604148A priority patent/CA2604148C/en
Publication of CA2429228A1 publication Critical patent/CA2429228A1/en
Application granted granted Critical
Publication of CA2429228C publication Critical patent/CA2429228C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Packages (AREA)
  • Saccharide Compounds (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Disclosed is a process for the crystallization of sucralose from an aqueous solution, the process comprising controlling the pH of said aqueous solution so as to maintain the pH in the range of from about 5.5 to about 8.5 during the formation of sucralose crystals. Also disclosed is crystalline sucralose crystallized from an aqueous sucralose solution having a pH in the range of from about pH 5.5 to about pH 8.5, and a nonhydrous crystalline sucralose having a residual moisture content of from about 0.5 to about 10 percent by weight. This process avoids acidification of the mother liquor that can occur.
CA002429228A 2000-11-17 2001-11-16 Improved sucralose composition and process for the crystallization thereof Expired - Fee Related CA2429228C (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA2604326A CA2604326C (en) 2000-11-17 2001-11-16 Improved sucralose composition and process for the crystallization thereof
CA2604148A CA2604148C (en) 2000-11-17 2001-11-16 Improved sucralose composition and process for the crystallization thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24978200P 2000-11-17 2000-11-17
US60/249,782 2000-11-17
PCT/US2001/043491 WO2002040495A2 (en) 2000-11-17 2001-11-16 Improved sucralose composition and process for the crystallization thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CA2604148A Division CA2604148C (en) 2000-11-17 2001-11-16 Improved sucralose composition and process for the crystallization thereof
CA2604326A Division CA2604326C (en) 2000-11-17 2001-11-16 Improved sucralose composition and process for the crystallization thereof

Publications (2)

Publication Number Publication Date
CA2429228A1 true CA2429228A1 (en) 2002-05-23
CA2429228C CA2429228C (en) 2008-08-26

Family

ID=22944966

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002429228A Expired - Fee Related CA2429228C (en) 2000-11-17 2001-11-16 Improved sucralose composition and process for the crystallization thereof

Country Status (11)

Country Link
US (4) US6646121B2 (en)
EP (1) EP1339728B1 (en)
JP (2) JP4560637B2 (en)
KR (1) KR100854528B1 (en)
CN (1) CN1294139C (en)
AU (2) AU2691802A (en)
BR (1) BR0115482B1 (en)
CA (1) CA2429228C (en)
MX (1) MXPA03004402A (en)
RU (1) RU2279437C2 (en)
WO (1) WO2002040495A2 (en)

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PT2522365T (en) 2004-11-24 2017-02-08 Meda Pharmaceuticals Inc Compositions comprising azelastine and methods of use thereof
US20070020330A1 (en) 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
JP4737977B2 (en) * 2004-11-30 2011-08-03 株式会社ケーヒン Valve device for fuel cell
CN101090906B (en) * 2004-12-28 2012-07-04 日本甜菜制糖株式会社 Process for producing difructose dianhydride iii crystal
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US20060247180A1 (en) * 2005-04-29 2006-11-02 Bergey James L Purgative composition and uses thereof
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US20070264403A1 (en) * 2006-05-11 2007-11-15 Nehmer Warren L Sparkling agglomerated sweetener, and method of making it
US8791253B2 (en) * 2006-06-19 2014-07-29 The Coca-Cola Company Rebaudioside A composition and method for purifying rebaudioside A
US9012626B2 (en) * 2006-06-19 2015-04-21 The Coca-Cola Company Rebaudioside a composition and method for purifying rebaudioside a
JP2009542625A (en) * 2006-07-06 2009-12-03 アレムビック・リミテッド Improved production of high purity sucralose
GB0702857D0 (en) * 2007-01-19 2007-03-28 Tate & Lyle Plc Improved sucralose production method
CN101260127B (en) * 2007-03-06 2011-04-20 盐城捷康三氯蔗糖制造有限公司 Method for synthesizing trichlorosucrose by deacetylation of trichlorosucrose-6-ethyl ester
US8030481B2 (en) 2007-05-21 2011-10-04 The Coca-Cola Company Stevioside polymorphic and amorphous forms, methods for their formulation, and uses
CN101686721A (en) * 2007-06-01 2010-03-31 曹耀海 sweetening compositions
US8436156B2 (en) * 2008-01-04 2013-05-07 Tate & Lyle Technology Limited Method for the production of sucralose
KR20100130219A (en) * 2008-03-20 2010-12-10 테이트 앤드 라일 테크놀러지 리미티드 Removal of acids from tertiary amide solvents
US8436157B2 (en) * 2008-03-26 2013-05-07 Tate & Lyle Technology Limited Method for the production of sucralose
WO2009137193A2 (en) * 2008-04-03 2009-11-12 Tate & Lyte Technology Ltd Effect of carbohydrate concentration on sucralose extraction efficiency
US8497367B2 (en) * 2008-04-03 2013-07-30 Tate & Lyle Technology Limited Sucralose purification process
US20090259036A1 (en) * 2008-04-03 2009-10-15 Tate & Lyle Technology Limited Extraction of less polar impurities from sucralose containing aqueous feed streams
AR071134A1 (en) * 2008-04-03 2010-05-26 Tate & Lyle Technology Ltd CRYSTALLIZATION OF SUCRALOSE FROM SQURALOSA CONTAINING
WO2009140345A2 (en) * 2008-05-15 2009-11-19 Tate & Lyle Technology Ltd Buffer rinsed sucralose crystals
GB2468936B (en) 2009-03-27 2011-09-07 Mohamad Rami Radwan Jaber Chlorination of sucrose-6-esters
GB2469157B (en) 2009-03-30 2011-07-06 John Kerr Process for removing dimethylamine during sucralose production
GB2469158B (en) 2009-03-31 2011-09-28 Peter J Seaberg Base-assisted formation of tin-sucrose adducts
WO2011024199A1 (en) * 2009-08-25 2011-03-03 V.B. Medicare Pvt. Ltd. Liquid sucralose sweetener composition
GB2474311B (en) * 2009-10-12 2012-10-17 Tate & Lyle Technology Ltd Low temperature, single solvent process for the production of sucrose-6-ester
GB2474310B (en) * 2009-10-12 2012-02-29 Tate & Lyle Technology Ltd Process for the production of sucrose-6-ester
GB201110520D0 (en) 2011-05-10 2011-08-03 Tate & Lyle Technology Ltd Extraction of carboxylic acids with tin compounds
CN102391319B (en) * 2011-10-14 2015-01-07 山东三和维信生物科技有限公司 Trichlorosucrose crystallizing method
CN102391320B (en) * 2011-12-23 2014-03-19 盐城捷康三氯蔗糖制造有限公司 Method for purifying sucralose by solvent thermal refluxing
GB2503644A (en) * 2012-05-03 2014-01-08 British American Tobacco Co Filter
CN102977157A (en) * 2012-12-05 2013-03-20 溧阳维信生物科技有限公司 Crystallization method for sucralose
CN103242384B (en) * 2013-05-27 2015-12-02 南通市常海食品添加剂有限公司 Mother liquor of sucralose extraction process
US10227367B2 (en) 2013-12-16 2019-03-12 Tate & Lyle Technology Limited Chlorination of sucrose-6-esters
WO2016020635A1 (en) 2014-08-08 2016-02-11 Tate & Lyle Technology Limited Chlorination of sucrose-6-esters
GB2536480B (en) 2015-03-17 2019-09-04 Tate & Lyle Tech Ltd DMF Distillation
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CN109762030A (en) * 2019-03-06 2019-05-17 福州大学 A kind of method for crystallising of Sucralose
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Also Published As

Publication number Publication date
CN1486326A (en) 2004-03-31
US6646121B2 (en) 2003-11-11
JP2004517071A (en) 2004-06-10
EP1339728A2 (en) 2003-09-03
US20050013922A1 (en) 2005-01-20
KR20030055310A (en) 2003-07-02
US20040024200A1 (en) 2004-02-05
JP2009298803A (en) 2009-12-24
BR0115482A (en) 2003-10-21
KR100854528B1 (en) 2008-08-26
CA2429228C (en) 2008-08-26
US20020120134A1 (en) 2002-08-29
US6809198B2 (en) 2004-10-26
AU2002226918B2 (en) 2006-05-25
WO2002040495A2 (en) 2002-05-23
WO2002040495A3 (en) 2003-05-01
US8017767B2 (en) 2011-09-13
MXPA03004402A (en) 2003-09-05
US20070015916A1 (en) 2007-01-18
EP1339728B1 (en) 2013-02-27
JP4560637B2 (en) 2010-10-13
CN1294139C (en) 2007-01-10
BR0115482B1 (en) 2013-02-19
AU2691802A (en) 2002-05-27
RU2279437C2 (en) 2006-07-10

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EEER Examination request
MKLA Lapsed

Effective date: 20161116