CA2432872A1 - Pyrazole compounds useful as protein kinase inhibitors - Google Patents
Pyrazole compounds useful as protein kinase inhibitors Download PDFInfo
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- CA2432872A1 CA2432872A1 CA002432872A CA2432872A CA2432872A1 CA 2432872 A1 CA2432872 A1 CA 2432872A1 CA 002432872 A CA002432872 A CA 002432872A CA 2432872 A CA2432872 A CA 2432872A CA 2432872 A1 CA2432872 A1 CA 2432872A1
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- protein kinase
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Abstract
This invention describes novel pyrazole compounds of formula (II ):wherein Z1 is nitrogen or CR8; Q is -S-, -O-, -N(R4)-, or -CH (R6)-; R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; and Ry, R2, and R2' are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzeimer's disease.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25788700P | 2000-12-21 | 2000-12-21 | |
US60/257,887 | 2000-12-21 | ||
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MX2009006690A (en) | 2006-12-19 | 2009-07-31 | Vertex Pharma | Aminopyrimidines useful as inhibitors of protein kinases. |
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