CA2432900A1 - Induced phase transition method for the production of microparticles containing hydrophilic active agents - Google Patents

Induced phase transition method for the production of microparticles containing hydrophilic active agents Download PDF

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Publication number
CA2432900A1
CA2432900A1 CA002432900A CA2432900A CA2432900A1 CA 2432900 A1 CA2432900 A1 CA 2432900A1 CA 002432900 A CA002432900 A CA 002432900A CA 2432900 A CA2432900 A CA 2432900A CA 2432900 A1 CA2432900 A1 CA 2432900A1
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CA
Canada
Prior art keywords
production
hydrophilic active
active agents
phase transition
microparticles containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002432900A
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French (fr)
Other versions
CA2432900C (en
Inventor
Celal Albayrak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALRISE Biosystems GmbH
Nektar Therapeutics
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Nektar Therapeutics
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Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of CA2432900A1 publication Critical patent/CA2432900A1/en
Application granted granted Critical
Publication of CA2432900C publication Critical patent/CA2432900C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1694Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)

Abstract

Microparticles and a method for their production is described. The process of the present invention provides a simple, quick, and efficient one-pot process for the production of microparticles containing a hydrophilic active agent of various and uniform morphologies, including microcapsules, microspheres, and microsponges. The microparticles are preferably used for pharmaceutical applications.
CA002432900A 2000-12-21 2001-12-19 Induced phase transition method for the production of microparticles containing hydrophilic active agents Expired - Lifetime CA2432900C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25752700P 2000-12-21 2000-12-21
US60/257,527 2000-12-21
US30002101P 2001-06-21 2001-06-21
US60/300,021 2001-06-21
PCT/US2001/050105 WO2002049619A2 (en) 2000-12-21 2001-12-19 Induced phase transition method for the production of microparticles containing hydrophilic active agents

Publications (2)

Publication Number Publication Date
CA2432900A1 true CA2432900A1 (en) 2002-06-27
CA2432900C CA2432900C (en) 2007-09-11

Family

ID=26946029

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002432900A Expired - Lifetime CA2432900C (en) 2000-12-21 2001-12-19 Induced phase transition method for the production of microparticles containing hydrophilic active agents
CA002432904A Expired - Lifetime CA2432904C (en) 2000-12-21 2001-12-19 Induced phase transition method for the production of microparticles containing hydrophobic active agents

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002432904A Expired - Lifetime CA2432904C (en) 2000-12-21 2001-12-19 Induced phase transition method for the production of microparticles containing hydrophobic active agents

Country Status (10)

Country Link
US (2) US7252842B2 (en)
EP (2) EP1343478B1 (en)
JP (2) JP2004516262A (en)
AT (2) ATE361057T1 (en)
AU (3) AU2002232824A1 (en)
CA (2) CA2432900C (en)
DE (2) DE60130917T2 (en)
DK (1) DK1343480T4 (en)
ES (2) ES2286157T5 (en)
WO (2) WO2002049619A2 (en)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1341524T1 (en) * 2000-12-07 2012-02-29 Nycomed Gmbh Pharmaceutical preparation in the form of a paste comprising an acid-labile active ingredient
WO2002049619A2 (en) * 2000-12-21 2002-06-27 Inhale Therapeutic Systems, Inc. Induced phase transition method for the production of microparticles containing hydrophilic active agents
EP1344520B1 (en) * 2002-03-15 2007-10-03 Alrise Biosystems GmbH Microparticles and method for their production
US8506617B1 (en) * 2002-06-21 2013-08-13 Advanced Cardiovascular Systems, Inc. Micronized peptide coated stent
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
US8685428B2 (en) * 2002-12-10 2014-04-01 Advanced Cardiovascular Systems, Inc. Therapeutic composition and a method of coating implantable medical devices
US6887207B2 (en) * 2003-02-26 2005-05-03 Medtronic, Inc. Methods and apparatus for estimation of ventricular afterload based on ventricular pressure measurements
CA2520475C (en) * 2003-04-03 2012-10-09 Jessie L.-S. Au Tumor-targeting drug-loaded particles
GB0324086D0 (en) * 2003-10-14 2003-11-19 Glaxo Group Ltd Process for preparing a co-precipitate of a non-crystalline solid drug substance
DE10358461B4 (en) * 2003-12-13 2008-09-11 Man Roland Druckmaschinen Ag Gummierungsmedium
AU2005240078A1 (en) * 2004-04-30 2005-11-17 Allergan, Inc. Retinoid-containing sustained release intraocular drug delivery systems and related methods of manufacturing
WO2005112569A2 (en) * 2004-05-13 2005-12-01 Medtronic Vascular, Inc. Methods for compounding and delivering a therapeutic agent to the adventitia of a vessel
US20060057215A1 (en) * 2004-09-15 2006-03-16 Raiche Adrian T Method for the production of nanoparticles and microparticles by ternary agent concentration and temperature alteration induced immiscibility
US20090092650A1 (en) * 2004-12-15 2009-04-09 Warren Stephen L Sustained Delivery Formulations of Octreotide Compounds
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
ES2272156B1 (en) * 2005-04-18 2008-04-01 Italfarmaco, S.A. MICROPARTICULAR SYSTEMS.
EP2034904B1 (en) 2006-07-01 2015-06-03 Opus KSD, Inc. Tissue fasteners and related insertion devices
EP2044140B1 (en) 2006-07-20 2017-05-17 OrbusNeich Medical, Inc. Bioabsorbable polymeric composition for a medical device
CN101495094B (en) 2006-08-09 2011-11-09 精达制药公司 Osmotic delivery systems and piston assemblies
JP5302888B2 (en) * 2006-08-31 2013-10-02 エスケー ケミカルズ カンパニー リミテッド Method for producing drug-containing polymer microspheres and drug-containing polymer microspheres produced by the method
US8691321B2 (en) 2006-10-20 2014-04-08 Orbusneich Medical, Inc. Bioabsorbable polymeric composition and medical device background
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
US7887984B2 (en) * 2007-01-18 2011-02-15 Eastman Kodak Company Toner porous particles containing hydrocolloids
CN101657190B (en) * 2007-04-19 2013-09-11 东亚制药株式会社 A biodegradable microsphere composition suitable for the controlled release of glucose controlling peptide and formulation thereof
CN101715340A (en) 2007-04-23 2010-05-26 精达制药公司 The mixed suspension preparation of insulinotropic peptide and application thereof
US8124601B2 (en) * 2007-11-21 2012-02-28 Bristol-Myers Squibb Company Compounds for the treatment of Hepatitis C
ES2718612T3 (en) 2007-12-20 2019-07-03 Evonik Corp Procedure for preparing microparticles that have a low volume of residual solvent
WO2009102467A2 (en) 2008-02-13 2009-08-20 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
US9486531B2 (en) * 2008-06-03 2016-11-08 Indivior Uk Limited Dehydrated hydrogel inclusion complex of a bioactive agent with flowable drug delivery system
KR101706178B1 (en) 2008-06-16 2017-02-15 화이자 인코포레이티드 Drug loaded polymeric nanoparticles and methods of making and using same
WO2010005726A2 (en) 2008-06-16 2010-01-14 Bind Biosciences Inc. Therapeutic polymeric nanoparticles with mtor inhibitors and methods of making and using same
WO2010005725A2 (en) 2008-06-16 2010-01-14 Bind Biosciences, Inc. Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same
CN104248623B (en) * 2008-09-04 2020-04-03 安米林药品有限责任公司 Sustained release formulations using non-aqueous carriers
EA201100765A1 (en) 2008-12-15 2012-04-30 Бинд Биосаиэнсис Long-term circulation nanoparticles
US20100291027A1 (en) * 2009-05-14 2010-11-18 Jason Campbell Hyaluronic acid (ha) injection vehicle
US9637408B2 (en) * 2009-05-29 2017-05-02 Corsam Technologies Llc Fusion formable sodium containing glass
EP2462246B1 (en) 2009-09-28 2017-09-06 Intarcia Therapeutics, Inc Rapid establishment and/or termination of substantial steady-state drug delivery
US20110081420A1 (en) * 2009-10-07 2011-04-07 Zyga Technology, Inc. Method of forming prolonged-release injectable steroids
WO2011072218A2 (en) 2009-12-11 2011-06-16 Bind Biosciences Stable formulations for lyophilizing therapeutic particles
EA201290499A1 (en) * 2009-12-15 2013-01-30 Байнд Байосайенсиз, Инк. COMPOSITIONS OF THERAPEUTIC POLYMER NANOPARTICLES WITH HIGH GLASSING TEMPERATURE AND HIGH-MOLECULAR CO-POLYMERS
WO2011163469A1 (en) 2010-06-23 2011-12-29 Teva Pharmaceutical Industries Ltd. Hydrated form of anti-inflammatory roflumilast-n-oxide
UA111162C2 (en) 2010-08-04 2016-04-11 Флекшен Терап'Ютікс, Інк. INJECTION COMPOSITION OF TRIAMCINOLONE ACETONIDE FOR TREATMENT OF PAIN
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
AU2012290683B2 (en) * 2011-08-04 2017-07-13 Flexion Therapeutics, Inc. Corticosteroids for the treatment of joint pain
US8927619B2 (en) 2011-12-21 2015-01-06 Jorg Thomas Wilken Color-stabilized iodopropynyl butylcarbamate
SI2895156T1 (en) 2012-09-17 2019-08-30 Pfizer Inc. Process for preparing therapeutic nanoparticles
US9232943B2 (en) 2013-01-31 2016-01-12 Opus Ksd Inc. Delivering bioabsorbable fasteners
CA2928772A1 (en) * 2013-12-05 2015-06-11 Alrise Biosystems Gmbh Process for the production of drug formulations for oral administration
TWI636798B (en) 2014-03-14 2018-10-01 輝瑞大藥廠 Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US9321899B1 (en) * 2014-10-29 2016-04-26 Xerox Corporation Preparing latex using a biosolvent
EP3302354B1 (en) 2015-06-03 2023-10-04 i2o Therapeutics, Inc. Implant placement systems
CA2987081C (en) 2015-06-11 2022-08-30 Alrise Biosystems Gmbh Process for the preparation of drug loaded microparticles
KR102574993B1 (en) 2016-05-16 2023-09-06 인타르시아 세라퓨틱스 인코포레이티드 Glucagon-receptor selective polypeptides and methods of use thereof
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
CA3049034A1 (en) 2017-01-03 2018-07-12 Intarcia Therapeutics, Inc. Methods comprising continuous administration of a glp-1 receptor agonist and co-adminstration of a drug
CN106719638A (en) * 2017-01-04 2017-05-31 安徽国星生物化学有限公司 A kind of paraquat micro-capsule suspension and preparation method thereof
EP3372224A1 (en) 2017-03-07 2018-09-12 Alrise Biosystems GmbH New controlled drug delivery system using water miscible solvents for production of drug loaded micro- and nanoparticles
KR102047983B1 (en) * 2017-11-30 2019-11-22 주식회사 지투지바이오 Method for preparing biodegradable microsphere with improved safety and storage stability
CN109260173B (en) * 2018-11-15 2019-08-20 朗天药业(湖北)有限公司 A kind of thymalfasin pharmaceutical composition and preparation method thereof
CN114349986B (en) * 2021-12-28 2024-02-27 华熙生物科技股份有限公司 Method for increasing viscosity of glycerin and application

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL280825A (en) 1962-07-11
BE744162A (en) 1969-01-16 1970-06-15 Fuji Photo Film Co Ltd ENCAPSULATION PROCESS
DE2010115A1 (en) 1970-03-04 1971-09-16 Farbenfabriken Bayer Ag, 5090 Leverkusen Process for the production of micro-granules
BE792550A (en) 1971-12-23 1973-06-12 Agfa Gevaert Nv PROCEDURE FOR MANUFACTURE OF MICROCAPSULES
JPS528795B2 (en) 1971-12-30 1977-03-11
JPS523342B2 (en) 1972-01-26 1977-01-27
GB1413186A (en) 1973-06-27 1975-11-12 Toyo Jozo Kk Process for encapsulation of medicaments
US4166800A (en) 1977-08-25 1979-09-04 Sandoz, Inc. Processes for preparation of microspheres
US4732763A (en) 1978-10-17 1988-03-22 Stolle Research And Development Corporation Active/passive immunization of the internal female reproductive organs
US4384975A (en) 1980-06-13 1983-05-24 Sandoz, Inc. Process for preparation of microspheres
US4389330A (en) 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4675189A (en) 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US5366734A (en) 1981-02-16 1994-11-22 Zeneca Limited Continuous release pharmaceutical compositions
CH661206A5 (en) 1983-09-23 1987-07-15 Debiopharm Sa PROCESS FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF HORMONDEPENDENT DISEASES.
JPS60100516A (en) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd Preparation of sustained release microcapsule
US4568559A (en) 1984-02-06 1986-02-04 Biotek, Inc. Composite core coated microparticles and process of preparing same
US6410056B1 (en) * 1984-03-16 2002-06-25 The United States Of America As Represented By The Secretary Of The Army Chemotherapeutic treatment of bacterial infections with an antibiotic encapsulated within a biodegradable polymeric matrix
DE3678308D1 (en) 1985-02-07 1991-05-02 Takeda Chemical Industries Ltd METHOD FOR PRODUCING MICROCAPSULES.
JP2551756B2 (en) 1985-05-07 1996-11-06 武田薬品工業株式会社 Polyoxycarboxylic acid ester and method for producing the same
US4962091A (en) 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
IE59720B1 (en) 1986-08-11 1994-03-23 Innovata Biomed Ltd Pharmaceutical formulations comprising microcapsules
JPS63122620A (en) 1986-11-12 1988-05-26 Sanraku Inc Polylactic acid microsphere and production thereof
FR2608942B1 (en) 1986-12-31 1991-01-11 Centre Nat Rech Scient PROCESS FOR THE PREPARATION OF COLLOIDAL DISPERSIBLE SYSTEMS OF A SUBSTANCE, IN THE FORM OF NANOCAPSULES
US5690954A (en) 1987-05-22 1997-11-25 Danbiosyst Uk Limited Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material
US4897268A (en) 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
DE3738228A1 (en) 1987-11-11 1989-05-24 Hoechst Ag METHOD FOR PRODUCING BIODEGRADABLE MICRO-CAPSULES OF WATER-SOLUBLE PEPTIDES AND PROTEINS AND MICRO-CAPSULES OBTAINED BY THIS PROCESS
JP2670680B2 (en) 1988-02-24 1997-10-29 株式会社ビーエムジー Polylactic acid microspheres containing physiologically active substance and method for producing the same
US4902515A (en) 1988-04-28 1990-02-20 E. I. Dupont De Nemours And Company Polylactide compositions
ATE102134T1 (en) 1989-02-16 1994-03-15 Sig Schweiz Industrieges DEVICE FOR PASSENGER COACHES WITH UIC TOWING AND BUMPER DEVICES AND PASSENGER COACHES.
US5019400A (en) 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
HU221294B1 (en) 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier
US5271961A (en) 1989-11-06 1993-12-21 Alkermes Controlled Therapeutics, Inc. Method for producing protein microspheres
US5478564A (en) 1990-02-22 1995-12-26 Teva Pharmaceutical Industries, Ltd. Preparation of microparticles for controlled release of water-soluble substances
US6120805A (en) 1990-04-06 2000-09-19 Rhone-Poulenc Rorer Sa Microspheres, process for their preparation and their use
JP3116311B2 (en) 1990-06-13 2000-12-11 エーザイ株式会社 Manufacturing method of microsphere
NZ240214A (en) 1990-10-16 1993-02-25 Takeda Chemical Industries Ltd Polymer compositions comprising a polylactic acid and a copolymer of glycolic acid and a hydroxycarboxylic acid; use as carrier for prolonged release pharmaceutical compositions of water soluble drugs
IT1243390B (en) 1990-11-22 1994-06-10 Vectorpharma Int PHARMACEUTICAL COMPOSITIONS IN THE FORM OF PARTICLES SUITABLE FOR THE CONTROLLED RELEASE OF PHARMACOLOGICALLY ACTIVE SUBSTANCES AND PROCEDURE FOR THEIR PREPARATION.
CH683149A5 (en) 1991-07-22 1994-01-31 Debio Rech Pharma Sa Process for the preparation of microspheres of a biodegradable polymeric material.
GB9116610D0 (en) 1991-08-01 1991-09-18 Danbiosyst Uk Preparation of microparticles
CA2079509C (en) 1991-10-01 2002-05-14 Shigeyuki Takada Prolonged release microparticle preparation and production of the same
US5676968A (en) 1991-10-31 1997-10-14 Schering Aktiengesellschaft Transdermal therapeutic systems with crystallization inhibitors
DE4223169C1 (en) 1992-07-10 1993-11-25 Ferring Arzneimittel Gmbh Process for the microencapsulation of water-soluble active substances
JP2651320B2 (en) 1992-07-16 1997-09-10 田辺製薬株式会社 Method for producing sustained-release microsphere preparation
AU4198793A (en) 1992-07-24 1994-01-27 Takeda Chemical Industries Ltd. Microparticle preparation and production thereof
FR2693905B1 (en) 1992-07-27 1994-09-02 Rhone Merieux Process for the preparation of microspheres for the sustained release of the hormone LHRH and its analogs, microspheres and formulations obtained.
US5661125A (en) 1992-08-06 1997-08-26 Amgen, Inc. Stable and preserved erythropoietin compositions
DE69316101T2 (en) 1992-08-07 1998-10-22 Takeda Chemical Industries Ltd Manufacture of microcapsules containing water-soluble drugs
AU5171293A (en) 1992-10-14 1994-05-09 Regents Of The University Of Colorado, The Ion-pairing of drugs for improved efficacy and delivery
EP0625069B1 (en) 1992-10-26 1998-12-30 Schwarz Pharma Ag Method of manufacturing microcapsules
US5603960A (en) 1993-05-25 1997-02-18 O'hagan; Derek T. Preparation of microparticles and method of immunization
US5635216A (en) 1993-12-16 1997-06-03 Eli Lilly And Company Microparticle compositions containing peptides, and methods for the preparation thereof
US5500161A (en) 1993-09-21 1996-03-19 Massachusetts Institute Of Technology And Virus Research Institute Method for making hydrophobic polymeric microparticles
US6080429A (en) 1993-10-25 2000-06-27 Genentech, Inc. Method for drying microspheres
US5643605A (en) 1993-10-25 1997-07-01 Genentech, Inc. Methods and compositions for microencapsulation of adjuvants
US5650173A (en) 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
US5902565A (en) 1993-12-24 1999-05-11 Csl Limited Spray dried vaccine preparation comprising aluminium adsorbed immunogens
US5594091A (en) 1994-02-21 1997-01-14 Takeda Chemical Industries, Ltd. Matrix for sustained-release preparation
DE4406172C2 (en) 1994-02-25 2003-10-02 Sanol Arznei Schwarz Gmbh polyester
GB9406094D0 (en) 1994-03-28 1994-05-18 Univ Nottingham And University Polymer microspheres and a method of production thereof
FR2718642B1 (en) 1994-04-15 1996-07-12 Pf Medicament Biodegradable controlled release microspheres and their preparation process.
EP0763064B1 (en) 1994-05-15 2001-08-01 APBiotech Aktiebolag A method of manufacturing particles, and particles that can be produced in accordance with the method
US6007845A (en) 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
CA2223583A1 (en) 1995-06-07 1996-12-19 Alkermes Controlled Therapeutics Inc. Device for releasing aggregation-stabilized, biologically active agent
US6143211A (en) * 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
JP2909418B2 (en) 1995-09-18 1999-06-23 株式会社資生堂 Delayed release microsphere of drug
DE19545257A1 (en) * 1995-11-24 1997-06-19 Schering Ag Process for the production of morphologically uniform microcapsules and microcapsules produced by this process
CA2192782C (en) 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
WO1997022409A1 (en) 1995-12-21 1997-06-26 Drexel University Hollow polymer microcapsules and method of producing
US5985312A (en) 1996-01-26 1999-11-16 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers
US5611344A (en) 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US5792477A (en) 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent
GB2316316A (en) 1996-08-23 1998-02-25 Int Centre Genetic Eng & Bio Sustained release of erythropoietin from microspheres
US5766637A (en) 1996-10-08 1998-06-16 University Of Delaware Microencapsulation process using supercritical fluids
EP0839525B1 (en) 1996-10-31 2004-08-04 Takeda Chemical Industries, Ltd. Sustained-release preparation
AUPO379596A0 (en) * 1996-11-22 1996-12-19 Soltec Research Pty Ltd Percutaneous delivery system
IL130532A0 (en) 1996-12-20 2000-06-01 Alza Corp Gel composition and methods
AU5806898A (en) * 1996-12-31 1998-07-31 Inhale Therapeutic Systems Processes and compositions for spray drying hydrophobic drugs in organic solventsuspensions of hydrophilic excipients
US5783567A (en) 1997-01-22 1998-07-21 Pangaea Pharmaceuticals, Inc. Microparticles for delivery of nucleic acid
US6048551A (en) 1997-03-27 2000-04-11 Hilfinger; John M. Microsphere encapsulation of gene transfer vectors
US6020004A (en) 1997-04-17 2000-02-01 Amgen Inc. Biodegradable microparticles for the sustained delivery of therapeutic drugs
SE512663C2 (en) 1997-10-23 2000-04-17 Biogram Ab Active substance encapsulation process in a biodegradable polymer
EP1028746B1 (en) 1997-11-07 2003-02-26 Chiron Corporation Method for producing igf-i sustained-release formulations
US6197229B1 (en) 1997-12-12 2001-03-06 Massachusetts Institute Of Technology Method for high supercoiled DNA content microspheres
GB9810236D0 (en) 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
KR19990085365A (en) 1998-05-16 1999-12-06 허영섭 Biodegradable polymer microspheres capable of continuously controlled controlled release and preparation method thereof
WO2000004916A1 (en) 1998-07-23 2000-02-03 Societe De Conseils De Recherches Et D'applications Scientifiques Sas Encapsulation of water soluble peptides
KR20010082309A (en) * 1998-11-18 2001-08-29 로날드 엠. 쿠들라 Methods for preparing coated drug particles and pharmaceutical formulations thereof
US6194006B1 (en) 1998-12-30 2001-02-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of microparticles having a selected release profile
DE19916384A1 (en) 1999-03-31 2000-10-05 Schering Ag Microparticles useful in treatment of androgen-dependent disorders include biodegradable, synthetic polymers of e.g. polyesters of hydroxycarboxylic acids
US6291013B1 (en) 1999-05-03 2001-09-18 Southern Biosystems, Inc. Emulsion-based processes for making microparticles
FR2797784B1 (en) 1999-08-27 2001-11-30 Mainelab PROCESS FOR THE ENCAPSULATION OF ACTIVE MATERIALS BY COACERVATION OF POLYMERS IN NON-CHLORINE ORGANIC SOLVENT
WO2002049619A2 (en) * 2000-12-21 2002-06-27 Inhale Therapeutic Systems, Inc. Induced phase transition method for the production of microparticles containing hydrophilic active agents

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