CA2443314A1 - Method of imaging cell death in vivo - Google Patents

Method of imaging cell death in vivo Download PDF

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Publication number
CA2443314A1
CA2443314A1 CA002443314A CA2443314A CA2443314A1 CA 2443314 A1 CA2443314 A1 CA 2443314A1 CA 002443314 A CA002443314 A CA 002443314A CA 2443314 A CA2443314 A CA 2443314A CA 2443314 A1 CA2443314 A1 CA 2443314A1
Authority
CA
Canada
Prior art keywords
vivo
cell death
imaging cell
imaging
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002443314A
Other languages
French (fr)
Other versions
CA2443314C (en
Inventor
H. W. Strauss
Francis G. Blankenberg
Allan M. Green
Neil Steinmetz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Theseus Imaging Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2443314A1 publication Critical patent/CA2443314A1/en
Application granted granted Critical
Publication of CA2443314C publication Critical patent/CA2443314C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/087—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being an annexin, e.g. annexin V
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

A method of imaging apoptosis in vivo, using radiolabeled annexin, is described. Methods for tumor radiotherapy are also provided.
CA002443314A 2001-04-03 2002-04-03 Method of imaging cell death in vivo Expired - Lifetime CA2443314C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28135201P 2001-04-03 2001-04-03
US60/281,352 2001-04-03
PCT/US2002/010507 WO2002082044A2 (en) 2001-04-03 2002-04-03 Method of imaging cell death in vivo

Publications (2)

Publication Number Publication Date
CA2443314A1 true CA2443314A1 (en) 2002-10-17
CA2443314C CA2443314C (en) 2006-03-21

Family

ID=23076927

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002443314A Expired - Lifetime CA2443314C (en) 2001-04-03 2002-04-03 Method of imaging cell death in vivo

Country Status (6)

Country Link
US (2) US6726895B2 (en)
EP (1) EP1381839A4 (en)
JP (1) JP2004529922A (en)
AU (1) AU2006201699A1 (en)
CA (1) CA2443314C (en)
WO (1) WO2002082044A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050013778A1 (en) * 2001-04-03 2005-01-20 Theseus Imaging Corporation Methods and compositions for predicting the response to a therapeutic regimen in a subject having a disease associated with cell death
US6726895B2 (en) * 2001-04-03 2004-04-27 Board Of Trustees Of The Leland Stanford Junior University Method of imaging cell death in vivo
US20040042959A1 (en) * 2002-08-28 2004-03-04 Michael Montalto Imaging cell death in vivo using non-radionuclide contrast agents
WO2005028490A1 (en) * 2003-09-19 2005-03-31 Theseus Imaging Corporation Halogenated deoxy-glucose labeled targeting molecules
US20060024315A1 (en) 2004-06-02 2006-02-02 Sidney Kimmel Cancer Center Vascular targets for detecting, imaging and treating neoplasia or neovasculature
CA2572453A1 (en) * 2004-06-02 2005-12-15 Sidney Kimmel Cancer Center Imaging and therapeutic agents targeting proteins expressed on endothelial cell surface
HUE024953T2 (en) * 2004-08-23 2016-02-29 Yeda Res & Dev Peptide inhibitors for mediating stress responses
BRPI0617195A2 (en) * 2005-10-14 2011-07-19 Stichting Katholieke Univ labeled interleukin-8 through one or more specifically conjugated portions of hydrazinonicotinamide (hynic) and their use in the diagnosis of infection and inflammation
US7871623B2 (en) * 2005-12-21 2011-01-18 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for imaging pain and stress in vivo
JP5319121B2 (en) 2007-01-30 2013-10-16 株式会社東芝 Medical support system and medical support device
US7809976B2 (en) * 2007-04-30 2010-10-05 Netapp, Inc. System and method for failover of guest operating systems in a virtual machine environment
KR100968839B1 (en) * 2008-02-25 2010-07-09 경북대학교 산학협력단 Polypeptide binding phosphatidylserine specifically and use thereof
US20110152679A1 (en) * 2009-12-17 2011-06-23 David Morag Systems and methods for generating colored persistence images in nuclear medicine imaging
US20140088017A1 (en) 2011-05-23 2014-03-27 Yeda Research And Development Co., Ltd. Use of akt phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same
MX2021000264A (en) 2018-07-11 2021-05-12 Immunity Pharma Ltd Peptide compounds and therapeutic uses of same.
IL272074A (en) 2020-01-15 2021-07-29 Immunity Pharma Ltd Peptide compounds and methods of treating diseases using same

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4671256A (en) 1984-05-25 1987-06-09 Lemelson Jerome H Medical scanning, monitoring and treatment system and method
US4816392A (en) * 1984-10-02 1989-03-28 Research Corporation Of The University Of Hawaii Rapid stick test for detection of ciguatoxin and other polyether toxins from tissues
US5627036A (en) 1989-12-27 1997-05-06 Boehringer Ingelheim International Gmbh Use of an anticoagulant as a diagnostic agent
US5552525A (en) 1991-02-08 1996-09-03 Diatech Inc. Technetium-99m labeled peptides for imaging inflammation
CA2086437A1 (en) 1991-05-09 1992-11-10 Jonathan Tait Phospholipid-targeted thrombolytic agents
US5632986A (en) 1991-05-09 1997-05-27 The University Of Washington Phospholipid-targeted thrombolytic agents
US5519221A (en) 1992-01-22 1996-05-21 Ansel M. Schwartz Dedicated apparatus and method for emission mammography
US5965132A (en) 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
ES2193143T3 (en) 1992-03-05 2003-11-01 Univ Texas USE OF IMMUNOCONJUGADOS FOR THE DIAGNOSIS AND / OR THERAPY OF VASCULARIZA TUMORS.
US5776427A (en) 1992-03-05 1998-07-07 Board Of Regents, The University Of Texas System Methods for targeting the vasculature of solid tumors
US6217869B1 (en) * 1992-06-09 2001-04-17 Neorx Corporation Pretargeting methods and compounds
GB9223168D0 (en) 1992-11-05 1992-12-16 Johnson Matthey Plc Improvements in molecule labelling
US5968477A (en) 1994-01-24 1999-10-19 Neorx Corporation Radiolabeled annexin conjugates with hexose and a chelator
CA2180555C (en) * 1994-01-24 2004-12-14 Sudhakar Kasina Radiolabeled annexins
NZ283171A (en) 1994-04-11 1998-02-26 Nexins Research Bv Detecting or quantifying apoptotic cells in a sample
EP0765166B1 (en) * 1994-06-16 2003-05-21 Neorx Corporation Radiolabeled annexin-galactose conjugates
WO1996017618A1 (en) 1994-12-07 1996-06-13 Neorx Corporation Radiolabeled annexin-galactose cluster conjugates
JPH10512852A (en) * 1994-12-07 1998-12-08 ネオルクス コーポレイション Radiolabeled annexin-galactose cluster complex
DE19541284C2 (en) * 1995-11-06 1998-09-24 Kalden Joachim Robert Prof Dr Immunomodulation method
DE69838811T2 (en) * 1997-04-30 2008-10-30 The Board Of Trustees Of The Leland Stanford Junior University, Stanford PROCESS FOR DISPLAYING DEADLY LEAVED CELLS IN VIVO
EP1098665B9 (en) * 1998-07-13 2003-08-13 The Board Of Regents, The University Of Texas System Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids
US6406693B1 (en) 1998-07-13 2002-06-18 Board Of Regents, The University Of Texas System Cancer treatment methods using antibodies to aminophospholipids
CA2349627A1 (en) 1998-11-04 2000-05-11 William A. Easterbrook, Iii Ventricular assist device with pre-formed inflation bladder
US6323313B1 (en) 1999-06-01 2001-11-27 The University Of Washington Annexin derivative with endogenous chelation sites
CN1292798C (en) * 2000-06-02 2007-01-03 德克萨斯州立大学董事会 Ethylenedicysteine (EC)-drug conjugates
WO2002080754A2 (en) * 2001-04-03 2002-10-17 Theseus Imaging Corporation Methods for using annexin for detecting cell death in vivo and treating associated conditions
US6726895B2 (en) * 2001-04-03 2004-04-27 Board Of Trustees Of The Leland Stanford Junior University Method of imaging cell death in vivo

Also Published As

Publication number Publication date
US20030003047A1 (en) 2003-01-02
JP2004529922A (en) 2004-09-30
EP1381839A4 (en) 2005-10-12
CA2443314C (en) 2006-03-21
AU2006201699A1 (en) 2006-05-18
EP1381839A2 (en) 2004-01-21
WO2002082044A3 (en) 2002-12-12
US6726895B2 (en) 2004-04-27
US20040170603A1 (en) 2004-09-02
WO2002082044A2 (en) 2002-10-17

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Effective date: 20220404