CA2450070A1 - Endovascular filter - Google Patents

Endovascular filter Download PDF

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Publication number
CA2450070A1
CA2450070A1 CA002450070A CA2450070A CA2450070A1 CA 2450070 A1 CA2450070 A1 CA 2450070A1 CA 002450070 A CA002450070 A CA 002450070A CA 2450070 A CA2450070 A CA 2450070A CA 2450070 A1 CA2450070 A1 CA 2450070A1
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CA
Canada
Prior art keywords
another
filter
agent
blood vessel
introduction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002450070A
Other languages
French (fr)
Other versions
CA2450070C (en
Inventor
Dennis Griffin
Arne Molgaard-Nielsen
Anthony O. Ragheb
Raymond B. Ii Leonard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cook Inc
Original Assignee
Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2450070A1 publication Critical patent/CA2450070A1/en
Application granted granted Critical
Publication of CA2450070C publication Critical patent/CA2450070C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01—Filters implantable into blood vessels
    • A61F2/0105—Open ended, i.e. legs gathered only at one side
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01—Filters implantable into blood vessels
    • A61F2002/016—Filters implantable into blood vessels made from wire-like elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028—Shapes in the form of latin or greek characters
    • A61F2230/005—Rosette-shaped, e.g. star-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0067—Three-dimensional shapes conical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0086—Pyramidal, tetrahedral, or wedge-shaped

Abstract

Endovascular filter (10) including a plurality of struts (14) with distal en ds (18) adapted to anchor the filter to the vessel wall after deployment, such as by having barbs (20), the filter being adapted to be retrieved if 5 desired. Strut distal ends (18) are coated with an antiproliferative agent (40) that inhibits the ingrowth of tissue around the filter, thereby permitting the filter to be retrieved and removed atraumatically after a prolonged period o f time, thus extending the useful life of the retrievable filter. Optionally, the proximal end (22) of the filter may also be so coated, or the entire filter.

Claims (23)

1. A collapsible vena cava filter for introduction into a blood vessel of a patient comprising:

an apical hub;

a plurality of struts secured to and diverging from said apical hub, each of said plurality of struts terminating in holding mechanisms that engage the walls of the blood vessel to secure the filter in a selected location therein;
filter media connected to said struts and spanning the space between the struts;

a bioactive coating applied to the surfaces of said filter to prevent the growth of tissue that would interfere with removal of the filter as well as medicate the patient; and wherein said layer of bioactive material contains from about 0.1 to 10.0 µg/mm2, more preferably about 1.0 to 5.0 µg/mm2, and most preferred about 3.0 µg/mm2 of the coated surface area.
2. A collapsible vena cava filter for introduction into a blood vessel of a patient as set forth in claim 1 wherein the bioactive coating is paclitaxel.
3. A collapsible vena cava filter for introduction into a blood vessel of a patient as set forth in claim 1 wherein the bioactive coating is dexamethasone or related compounds.
4. A collapsible vena cava filter for introduction into a blood vessel of a patient as set forth in claim 1 wherein the bioactive coating is applied to surfaces of the apical hub, struts and filter media that could engage the vessel wall.
5. A collapsible vena cava filter for introduction into a blood vessel of a patient as set forth in claim 1 wherein the bioactive coating is applied to the gross surfaces area of the filter.
6. A collapsible vena cava filter for introduction into a blood vessel of a patient as set forth in claim 1 wherein an excipient may be associated with said bioactive coating.
7. A collapsible vena cava filter for introduction into a blood vessel of a patient as set forth in claim 4 or 5 wherein the bioactive coating is paclitaxel.
8. A collapsible vena cava filter for introduction into a blood vessel of a patient as set forth in claim 1 or 4 or 5 wherein the bioactive coating includes at least one of heparin, covalent heparin, or another thrombin inhibitor, hirudin, hirulog, argatroban, D-phenylalanyl-L-poly-L-arginyl chloromethyl ketone, or another antithrombogenic agent, or mixtures thereof;

urokinase, streptokinase, a tissue plasminogen activator, or another thrombolytic agent, or mixtures thereof; a fibrinolytic agent; a vasospasm inhibitor; a calcium channel blocker, a nitrate, nitric oxide, a nitric oxide promoter or another vasodilator; Hytrin® or other antihypertensive agents;
an antimicrobial agent or antibiotic; aspirin, ticlopidine, a glycoprotein IIb/IIIa inhibitor or another inhibitor of surface glycoprotein receptors, or another antiplatelet agent; colchicine or another antimitotic, or another microtubule inhibitor, dimethyl sulfoxide (DMSO), a retinoid or another antisecretory agent;
cytochalasin or another actin inhibitor; or a remodelling inhibitor;
deoxyribonucleic acid, an antisense nucleotide or another agent for molecular genetic intervention; methotrexate or another antimetabolite or antiproliferative agent; tamoxifen citrate, Taxol® or the derivatives thereof, or other anti-cancer chemotherapeutic agents; dexamethasone, dexamethasone sodium phosphate, dexamethasone acetate or another dexamethasone derivative, or another anti-inflammatory steroid or non-steroidal antiinflammatory agent; cyclosporin or another immunosuppressive agent;
trapidal (a PDGF antagonist), angiopeptin (a growth hormone antagonist), angiogenin, a growth factor or an anti-growth factor antibody, or another growth factor antagonist; dopamine, bromocriptine mesylate, pergolide mesylate or another dopamine agonist; 60Co (5.3 year half life), 192Ir (73.8 days), 32P (14.3 days), 111In (68 hours), 90.gamma. (64 hours), 99m Tc (6 hours) or another radiotherapeutic agent; iodine-containing compounds, barium-containing compounds, gold, tantalum, platinum, tungsten or another heavy metal functioning as a radiopaque agent; a peptide, a protein, an enzyme, an extracellular matrix component, a cellular component or another biologic agent; captopril, enalapril or another angiotensin converting enzyme (ACE) inhibitor; ascorbic acid, alpha tocopherol, superoxide dismutase, deferoxamine, a 21-aminosteroid (lasaroid) or another free radical scavenger, iron chelator or antioxidant; a 14C-, 3H-,131I-, 32P- or 36S-radiolabelled form or other radiolabelled form of any of the foregoing; estrogen or another sex hormone; AZT or other anti polymerases; acyclovir, famciclovir, rimantadine hydrochloride, ganciclovir sodium, Norvir, Crixivan, or other antiviral agents;
5-aminolevulinic acid, meta-tetrahydroxyphenylchlorin, hexadecafluoro zinc phthalocyanine, tetramethyl hematoporphyrin, rhodamine 123 or other photodynamic therapy agents; an IgG2 Kappa antibody against Pseudomonas aeruginosa exotoxin A and reactive with A431 epidermoid carcinoma cells, monoclonal antibody against the noradrenergic enzyme dopamine beta-hydroxylase conjugated to saporin or other antibody targeted therapy agents; gene therapy agents; and enalapril and other prodrugs;
Proscar®, Hytrin® or other agents for treating benign prostatic hyperplasia (BHP) or a mixture of any of these; and various forms of small intestine submucosa (SIS).
9. A collapsible vena cava filter for introduction into a blood vessel of a patient comprising:

an apical hub;

a plurality of struts secured to and diverging from said apical hub, each of said plurality of struts terminating in holding mechanisms that engage the walls of the blood vessel to secure the filter in a selected location therein;

filter media connected to said struts and spanning the space between the struts;

a bioactive coating applied to the surfaces of said filter to prevent the growth of tissue that would interfere with removal of the filter as well as medicate the patient; and wherein said layer of bioactive material contains about 100 µg to about 300 µg of drug per 0.001 inch of coating thickness.
10. A collapsible vena cava filter for introduction into a blood vessel of a patient as set forth in claim 9 wherein the bioactive coating is paclitaxel.
11. A collapsible vena cava filter for introduction into a blood vessel of a patient as set forth in claim 9 wherein the bioactive coating is dexamethasone or related compounds.
12. A collapsible vena cava filter for introduction into a blood vessel of a patient as set forth in claim 9 wherein the bioactive coating is applied to surfaces of the apical hub, struts and filter media that could engage the vessel wall.
13. A collapsible vena cava filter for introduction into a blood vessel of a patient as set forth in claim 9 wherein the bioactive coating is applied to the gross surfaces area of the filter.
14. A collapsible vena cava filter for introduction into a blood vessel of a patient as set forth in claim 12 or 13 wherein the bioactive coating is paclitaxel.
15. A collapsible vena cava filter for introduction into a blood vessel of a patient as set forth in claim 9 or 12 or 13 wherein the bioactive coating includes at least one of heparin, covalent heparin, or another thrombin inhibitor, hirudin, hirulog, argatroban, D-phenylalanyl-L-poly-L-arginyl chloromethyl ketone, or another antithrombogenic agent, or mixtures thereof;
urokinase, streptokinase, a tissue plasminogen activator, or another thrombolytic agent, or mixtures thereof; a fibrinolytic agent; a vasospasm inhibitor; a calcium channel blocker, a nitrate, nitric oxide, a nitric oxide promoter or another vasodilator; Hytrin® or other antihypertensive agents;
an antimicrobial agent or anfiibiotic; aspirin, ticlopidine, a glycoprotein IIb/IIIa inhibitor or another inhibitor of surface glycoprotein receptors, or another antiplatelet agent; colchicine or another antimitotic, or another microtubule inhibitor, dimethyl sulfoxide (DMSO), a retinoid or another antisecretory agent;
cytochalasin or another actin inhibitor; or a remodelling inhibitor;
deoxyribonucleic acid, an antisense nucleotide or another agent for molecular genetic intervention; methotrexate or another antimetabolite or antiproliferative agent; tamoxifen citrate, Taxol® or the derivatives thereof, or other anti-cancer chemotherapeutic agents; dexamethasone, dexamethasone sodium phosphate, dexamethasone acetate or another dexamethasone derivative, or another anti-inflammatory steroid or non-steroidal antiinflammatory agent; cyclosporin or another immunosuppressive agent;
trapidal (a PDGF antagonist), angiopeptin (a growth hormone antagonist), angiogenin, a growth factor or an anti-growth factor antibody, or another growth factor antagonist; dopamine, bromocriptine mesylate, pergolide mesylate or another dopamine agonist; 60Co (5.3 year half life), 192Ir (73.8 days), 32P (14.3 days), 111In (68 hours), 90.UPSILON. (64 hours), 99m TC (6 hours) or another radiotherapeutic agent; iodine-containing compounds, barium-containing compounds, gold, tantalum, platinum, tungsten or another heavy metal functioning as a radiopaque agent; a peptide, a protein, an enzyme, an extracellular matrix component, a cellular component or another biologic agent; captopril, enalapril or another angiotensin converting enzyme (ACE) inhibitor; ascorbic acid, alpha tocopherol, superoxide dismutase, deferoxamine, a 21-aminosteroid (lasaroid) or another free radical scavenger, iron chelator or antioxidant; a 14C-, 3H-,131I-, 32P- or 36S-radiolabelled form or other radiolabelled form of any of the foregoing; estrogen or another sex hormone; AZT or other anti polymerases; acyclovir, famciclovir, rimantadine hydrochloride, ganciclovir sodium, Norvir, Crixivan, or other antiviral agents;
5-aminolevulinic acid, meta-tetrahydroxyphenylchlorin, hexadecafluoro zinc phthalocyanine, tetramethyl hematoporphyrin, rhodamine 123 or other photodynamic therapy agents; an IgG2 Kappa antibody against Pseudomonas aeruginosa exotoxin A and reactive with A431 epidermoid carcinoma cells, monoclonal antibody against the noradrenergic enzyme dopamine beta-hydroxylase conjugated to saporin or other antibody targeted therapy agents; gene therapy agents; and enalapril and other prodrugs;
Proscar®, Hytrin® or other agents for treating benign prostatic hyperplasia (BHP) or a mixture of any of these; and various forms of small intestine submucosa (SIS).
16. A collapsible filter for introduction into a blood vessel of a patient, said collapsible filter having a proximal portion, a medial portion and a distal portion, comprising;

an apical hub, in the proximal portion of said filter, having a first or distal end and a second or proximal end;

a plurality of struts having proximal end and distal end portions, the proximal ends of said plurality of struts being secured to the first or distal end of said apical hub and diverging distally and outwardly therefrom, and each of said struts having an outwardly turned hook at their distal ends;
a pair of side element associated with each of said struts , each side element having a proximal portion and a distal portion, the proximal end of the proximal portions being secured to the first or distal end of said apical hub and diverging distally and outwardly therefrom such that the associated strut lies between the pair of side elements, the distal portion of each side element diverging inwardly toward said associated strut such that the distal ends of the pair of side elements meet and form an eyelet through which the assosciated strut passes in a sliding relationship, whereby the filter as a whole may be unfolded from a collapsed insertion condition in which the struts and side elements form a narrow bundle for arrangement in a catheter like insertion instrument into an open tulip like filter configuration with the side elements interoposed between the struts;

a deployment and retrieval section secured to and extending proximately from the second or proximal end of said apical hub;
a bioactive coating applied to the surfaces of said filter to prevent the growth of tissue that would interfere with removal of the filter as well as medicate the patient; and wherein the bioactive coating contains from about 0.1 to 10.0 µg/mm2, more preferably about 1.0 to 5.0 µg/mm2, and most preferred about 3.0 µg/mm2 of the coated surface area.
17. A collapsible filter for introduction into a blood vessel as set forth in claim 16, wherein:

said bioactive coating is applied to the distal end portion of the struts and their hooks to prevent the ingrowth of tissue to and therearound.
18. A collapsible filter for introduction into a blood vessel as set forth.
in claim 17, wherein:

said bioactive coating is also applied to said first or distal end of the apical hub and the deployment and retrieval section that is secured to the apical hub to prevent the ingrowth of tissue to and therearound.
19. A collapsible filter for introduction into a blood vessel as set forth in claim 16, wherein:

said bioactive coating is applied to the gross surface area of the filter to prevent the ingrowth of tissue to and therearound.
20. A collapsible filter for introduction into a blood vessel as set forth in each of claim 16 or 17 or 19 wherein:

said bioactive coating is dexamethasone.
21. A collapsible filter for introduction into a blood vessel as set forth in each of claims 16 or 17 or 19 wherein:
said bioactive coating is pacilitaxel.
22. A collapsible filter for introduction into a blood vessel of a patient as set forth in any of claims 15 or 16 or 18 wherein the layer of bioactive coating contains about 100 µg to about 300 µg of drug per 0.001 inch of coating thickness.
23. A collapsible filter for introduction into a blood vessel of a patient as set forth in any of claims 16 or 17 or 19 wherein the layer of bioactive coating includes at least one of heparin, covalent heparin, or another thrombin inhibitor, hirudin, hirulog, argatroban, D-phenylalanyl-L-poly-L-arginyl chloromethyl ketone, or another antithrombogenic agent, or mixtures thereof;
urokinase, streptokinase, a tissue plasminogen activator, or another thrombolytic agent, or mixtures thereof; a fibrinolytic agent; a vasospasm inhibitor; a calcium channel blocker, a nitrate, nitric oxide, a nitric oxide promoter or another vasodilator; Hytrin® or other antihypertensive agents;
an antimicrobial agent or antibiotic; aspirin, ticlopidine, a glycoprotein IIb/IIIa inhibitor or another inhibitor of surface glycoprotein receptors, or another antiplatelet agent; colchicine or another antimitotic, or another microtubule inhibitor, dimethyl sulfoxide (DMSO), a retinoid or another antisecretory agent;
cytochalasin or another actin inhibitor; or a remodelling inhibitor;
deoxyribonucleic acid, an antisense nucleotide or another agent for molecular genetic intervention; methotrexate or another antimetabolite or antiproliferative agent; tamoxifen citrate, Taxol® or the derivatives thereof, or other anti-cancer chemotherapeutic agents; dexamethasone, dexamethasone sodium phosphate, dexamethasone acetate or another dexamethasone derivative, or another anti-inflammatory steroid or non-steroidal antiinflammatory agent; cyclosporin or another immunosuppressive agent;
trapidal (a PDGF antagonist), angiopeptin (a growth hormone antagonist), angiogenin, a growth factor or an anti-growth factor antibody, or another growth factor antagonist; dopamine, bromocriptine mesylate, pergolide mesylate or another dopamine agonist; 60Co (5.3 year half life), 192Ir (73.8 days), 32P (14.3 days), 111In (68 hours), 90.UPSILON.(64 hours), 99mc (6 hours) or another radiotherapeutic agent; iodine-containing compounds, barium-containing compounds, gold, tantalum, platinum, tungsten or another heavy metal functioning as a radiopaque agent; a peptide, a protein, an enzyme, an extracellular matrix component, a cellular component or another biologic agent; captopril, enalapril or another angiotensin converting enzyme (ACE) inhibitor; ascorbic acid, alpha tocopherol, superoxide dismutase, deferoxamine, a 21-aminosteroid (lasaroid) or another free radical scavenger, iron chelator or antioxidant; a 14C-, 3H-, 131I-, 32P- or 36S-radiolabelled form or other radiolabelled form of any of the foregoing; estrogen or another sex hormone; AZT or other anti polymerases; acyclovir, famciclovir, rimantadine hydrochloride, ganciclovir sodium, Norvir, Crixivan, or other antiviral agents;
5-aminolevulinic acid, meta-tetrahydroxyphenylchlorin, hexadecafluoro zinc phthalocyanine, tetramethyl hematoporphyrin, rhodamine 123 or other photodynamic therapy agents; an IgG2 Kappa antibody against Pseudomonas aeruginosa exotoxin A and reactive with A431 epidermoid carcinoma cells, monoclonal antibody against the noradrenergic enzyme dopamine beta-hydroxylase conjugated to saporin or other antibody targeted therapy agents; gene therapy agents; and enalapril and other prodrugs;
Proscar®, Hytrin® or other agents for treating benign prostatic hyperplasia (BHP) or a mixture of any of these; and various forms of small intestine submucosa (SIS).
CA002450070A 2001-06-14 2002-06-14 Endovascular filter Expired - Lifetime CA2450070C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29880301P 2001-06-14 2001-06-14
US60/298,803 2001-06-14
PCT/US2002/018923 WO2002102436A2 (en) 2001-06-14 2002-06-14 Endovascular filter

Publications (2)

Publication Number Publication Date
CA2450070A1 true CA2450070A1 (en) 2002-12-27
CA2450070C CA2450070C (en) 2010-03-02

Family

ID=23152056

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002450070A Expired - Lifetime CA2450070C (en) 2001-06-14 2002-06-14 Endovascular filter

Country Status (6)

Country Link
US (1) US20020193828A1 (en)
EP (1) EP1412014A4 (en)
JP (1) JP4294470B2 (en)
AU (2) AU2007216636A1 (en)
CA (1) CA2450070C (en)
WO (1) WO2002102436A2 (en)

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WO2002102436A2 (en) 2002-12-27
EP1412014A4 (en) 2005-06-15
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CA2450070C (en) 2010-03-02

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