CA2451789A1 - Assay plates, reader systems and methods for luminescence test measurements - Google Patents
Assay plates, reader systems and methods for luminescence test measurements Download PDFInfo
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- CA2451789A1 CA2451789A1 CA002451789A CA2451789A CA2451789A1 CA 2451789 A1 CA2451789 A1 CA 2451789A1 CA 002451789 A CA002451789 A CA 002451789A CA 2451789 A CA2451789 A CA 2451789A CA 2451789 A1 CA2451789 A1 CA 2451789A1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/251—Colorimeters; Construction thereof
- G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/50—Clamping means, tongs
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L9/00—Supporting devices; Holding devices
- B01L9/56—Means for indicating position of a recipient or sample in an array
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
- G01N21/69—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence specially adapted for fluids, e.g. molten metal
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/02—Identification, exchange or storage of information
- B01L2300/021—Identification, e.g. bar codes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0829—Multi-well plates; Microtitration plates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0848—Specific forms of parts of containers
- B01L2300/0851—Bottom walls
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0418—Plate elements with several rows of samples
- G01N2035/042—Plate elements with several rows of samples moved independently, e.g. by fork manipulator
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0418—Plate elements with several rows of samples
- G01N2035/0425—Stacks, magazines or elevators for plates
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0474—Details of actuating means for conveyors or pipettes
- G01N2035/0491—Position sensing, encoding; closed-loop control
- G01N2035/0494—Detecting or compensating piositioning errors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49002—Electrical device making
- Y10T29/49117—Conductor or circuit manufacturing
- Y10T29/49124—On flat or curved insulated base, e.g., printed circuit, etc.
- Y10T29/49155—Manufacturing circuit on or in base
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T83/00—Cutting
- Y10T83/04—Processes
Abstract
Luminescence test measurements are conducted using an assay module (150) having integrated electrodes (166, 168) with a reader apparatus adapted to receive assay modules (150), induce luminescence, preferably electrode induced luminescence, in the wells (158) or assay regions of the assay modules and measure the induced luminescence.
Claims (474)
1. A multi-well plate for conducting luminescence assays comprising a plate bottom, wherein said plate bottom comprises independently addressable sectors of jointly addressable electrodes patterned thereon.
2. A multi-well plate having a plurality of wells, wherein said plurality of wells comprise: (a) a first set of two or more wells, each well comprising a first electrode surface and a second electrode surface, wherein said first electrode surfaces of said two or more wells of said first set are electrically connected and said second electrode surfaces of said two or more wells of said first set are electrically connected and (b) a second set of two or more wells, each well comprising a first electrode surface and a second electrode surface, wherein said first electrode surfaces of said two or more wells of said second set are electrically connected and said second electrode surfaces of said two or more wells of said second set are electrically connected, wherein said electrode surfaces of said first set and said electrode surfaces of said second set are independently addressable.
3. A multi-well plate having a plurality of wells, wherein two or more of said plurality of wells each comprise a working electrode surface and a counter electrode surface, wherein said working electrode surface and/or said counter electrode surface comprise carbon.
4. A multi-well plate comprising a plurality of wells, wherein two or more of said plurality of wells each comprise a working electrode surface and a counter electrode surface, wherein said working electrode surface and/or said counter electrode surface comprise screen printed carbon.
5. A multi-well plate having a plurality of wells, wherein two or more of said plurality of wells each comprise a working electrode surface and a counter electrode surface, wherein said working electrode surface comprises carbon and said counter electrode surface comprises a metal.
6. The multi-well plate of claim 5, wherein said metal comprises aluminum, silver or nickel.
7. The multi-well plate of claim 5, wherein said counter electrode surface comprises aluminum.
8. A multi-well plate having a plurality of wells, wherein two or more of said plurality of wells each comprise a working electrode surface and a counter electrode surface, wherein said counter electrode surface comprises a metal on an adhesive layer.
9. The multi-well plate of claim 8, wherein said metal comprises aluminum, silver or nickel.
10. The multi-well plate of claim 8, wherein said metal comprises aluminum.
11. A multi-well plate having a plurality of wells, wherein two or more of said wells have a first electrode surface and a second electrode surface, wherein said first electrode surface is centered at the bottom of said well and said second electrode surface is adjacent the periphery of the bottom of said well.
12. The multi-well plate of claim 11, wherein said first electrode surface is a working electrode and said second electrode surface is a counter electrode.
13. The multi-well plate of claim 11, wherein said first electrode surface and second electrode surface are at the same height within said wells.
14. The multi-well plate of claim 11, wherein said first electrode surface is completely surrounded by said second electrode surface.
15. A multi-well plate having a plurality of wells, said wells comprising a plurality of working electrodes per well.
16. The multi-well plate of claim 15, wherein said working electrodes comprise one or more proteins immobilized thereon.
17. A multi-well plate having a plurality of wells, said wells having a first electrode surface suitable for use as a working electrode in an electrode induced luminescence assay and a second electrode surface suitable for use as a counter electrode in said electrode induced luminescence assay, wherein the surface ratio of said first electrode surface to said second electrode surface is at least 2 to 1.
18. A multi-well plate having a plurality of wells, each well comprising a working electrode surface and a counter electrode surface, wherein the working electrode surface is bounded by a dielectric surface, said working electrode surface being less hydrophobic than said dielectric surface.
19. The multi-well plate of claim 18, wherein said working electrode surface has a contact angle for water 20 degrees less than the dielectric surface.
20. A multi-well plate having a plurality of wells, wherein at least one well comprises a working electrode surface bounded by a dielectric surface.
21. A multi-well plate having a plurality of wells, wherein at least one well comprises one or more working electrodes, at least one working electrode having one or more assay domains comprising immobilized reagents, said assay domains being defined by openings in one or more dielectric layers supported on said working electrodes.
22. A multi-well plate comprising a plate top having a plurality of rows of openings and a substrate having working electrode strips and counter electrode strips patterned thereon, wherein said plate top is affixed on said substrate thereby forming a plurality of rows of wells from said openings, wherein the bottom of each well comprises an exposed portion of at least one working electrode strip and two exposed edge portions of said counter electrode strips.
23. A multi-well plate comprising a plate top having a plurality of rows of openings and a substrate having working electrode strips and counter electrode strips patterned thereon, wherein said plate top is affixed on said substrate thereby forming a plurality of well rows from said plurality of openings, said well rows being aligned with said working electrode strips and said counter electrode strips, wherein said well rows comprise: (i) a first well comprising a first well bottom including a centered portion including an exposed portion of a first working electrode strip, a first edge portion including an exposed portion of a first counter electrode strip and a second edge portion including an exposed portion of a second counter electrode strip and (ii) at least a second well comprising a second well bottom including a second centered portion including an exposed portion of said first working electrode strip, a first edge portion including an exposed portion of said first counter electrode strip and a second edge portion including an exposed portion of said second counter electrode strip.
24. The multi-well plate of claim 23, wherein said well rows further comprise: (i) a third well comprising a third well bottom including a centered portion including an exposed portion of a second working electrode strip, a first edge portion including an exposed portion of a third counter electrode strip and a second edge portion including an exposed portion of a fourth counter electrode strip and (ii) at least a fourth well comprising a fourth well bottom including a fourth centered portion including an exposed portion of said second working electrode strip, a first edge portion including an exposed portion of said third counter electrode strip and a second edge portion including an exposed portion of said fourth counter electrode strip.
25. A multi-well plate having a plurality of wells and a substrate, said substrate having a first side and a second side, said substrate comprising a plurality of working electrode surfaces and a plurality of counter electrode surfaces on said first side and one or more conductive contacts on said second side, wherein two or more of said plurality of wells each comprise one or more working electrode surfaces and one or more counter electrode surfaces, wherein said substrate further comprises one or more conductive through-holes electrically connecting said one or more working electrode surfaces and said one or more counter electrode surfaces on said first side with said conductive contacts on said second side.
26. A multi-well plate having a plurality of wells and a substrate, said substrate having a first side and a second side and said substrate comprising one or more electrode surfaces on said first side and one or more conductive contacts on said second side, wherein said one or more electrode surfaces are electrically connected to said one or more conductive contacts.
27. The multi-well plate of claim 26, wherein said first side is a top surface of said multi-well plate and said second side is a bottom surface of said multi-well plate.
28. The multi-well plate of claim 26, wherein said substrate further comprises one or more conductive through-holes electrically connecting said one or more working electrode surfaces on said first side with said one or more conductive contacts on said second side.
29. A multi-well plate having a plurality of wells comprising an insulating substrate and a conductive substrate, wherein said conductive substrate is folded around said insulating substrate forming one or more electrode surfaces on a first side of said insulating substrate and one or more electrical contacts on a second side of said insulating substrate, said one or more electrical contacts being electrically connected to said one or more electrode surfaces.
30. A multi-well plate having a plurality of wells comprising a working electrode surface and a counter electrode surface adjacent a top surface of a substrate, wherein said substrate further comprises a bottom surface comprising a plurality of electrical contact locations positioned on said bottom surface between said plurality of wells.
31. A multi-well plate having an array of wells corresponding to a 96-well plate configuration, said array comprising one or more of the following:
a first sector having wells A1 through A4, B1 through B4, C1 through C4, and D1 through D4;
a second sector having wells A5 through A8, B5 through B8, C5 through C8, and D5 through D8;
a third sector having wells A9 through A12, B9 through B12, C9 through C12, and D9 through D12;
a fourth sector having wells E1 through E4, F1 through F4, G1 through G4, and H1 through H4;
a fifth sector having wells E5 through E8, F5 through F8, G5 through G8, and H5 through H8; and a sixth sector having wells E9 through E12, F9 through F12, G9 through G12, and H9 through H12;
said multi-well plate having a plurality of electrodes on a top surface and a plurality of contact surfaces on a bottom surface, wherein said plurality of electrodes are electrically connected to said plurality of contact surfaces.
a first sector having wells A1 through A4, B1 through B4, C1 through C4, and D1 through D4;
a second sector having wells A5 through A8, B5 through B8, C5 through C8, and D5 through D8;
a third sector having wells A9 through A12, B9 through B12, C9 through C12, and D9 through D12;
a fourth sector having wells E1 through E4, F1 through F4, G1 through G4, and H1 through H4;
a fifth sector having wells E5 through E8, F5 through F8, G5 through G8, and H5 through H8; and a sixth sector having wells E9 through E12, F9 through F12, G9 through G12, and H9 through H12;
said multi-well plate having a plurality of electrodes on a top surface and a plurality of contact surfaces on a bottom surface, wherein said plurality of electrodes are electrically connected to said plurality of contact surfaces.
32. The multi-well plate of claim 31, wherein said plurality of contact surfaces are located between or adjacent said wells.
33. The multi-well plate of claim 31, wherein said plurality of electrodes comprise one or more working electrodes and one or more counter electrodes and said plurality of contact surfaces comprises one or more working contacts electrically connected to said one or more working electrodes and one or more counter contacts electrically connected to said one or more counter electrodes.
34. The multi-well plate of claim 31, wherein said contact surfaces are located at one or more of the following locations:
(i) two or more of first sector locations: A1-B2; A2-B3; A3-B4; C1-D2; C2-D3;
C3-D4;
(ii) two or more of second sector locations: A5-B6; A6-B7; A7-B8; C5-D6; C6-D7; C7-D8;
(iii) two or more of third sector locations: A9-B10; A10-B11; A11-B12; C9-D10;
D11; C11-D12;
(iv) two or more of fourth sector locations: E1-F2; E2-F3; E3-F4; G1-H2; G2-H3; G3-H4;
(v) two or more of fifth sector locations: E5-F6; E6-F7; E7-F8; G5-H6; G6-H7;
G7-H8;
and (vi) two or more of sixth sector locations: E9-F10; E10-F11; E11-F12; G9-H10;
H11; G11-H12.
(i) two or more of first sector locations: A1-B2; A2-B3; A3-B4; C1-D2; C2-D3;
C3-D4;
(ii) two or more of second sector locations: A5-B6; A6-B7; A7-B8; C5-D6; C6-D7; C7-D8;
(iii) two or more of third sector locations: A9-B10; A10-B11; A11-B12; C9-D10;
D11; C11-D12;
(iv) two or more of fourth sector locations: E1-F2; E2-F3; E3-F4; G1-H2; G2-H3; G3-H4;
(v) two or more of fifth sector locations: E5-F6; E6-F7; E7-F8; G5-H6; G6-H7;
G7-H8;
and (vi) two or more of sixth sector locations: E9-F10; E10-F11; E11-F12; G9-H10;
H11; G11-H12.
35. The multi-well plate of claim 33, wherein (a) said working contacts are located at one or more of the following locations:
(i) one or more of first sector locations: A1-B2; A3-B4; C1-D2; and C3-D4;
(ii) one or more of second sector locations: A5-B6; A7-B8; C5-D6; and C7-D8;
(iii) one or more of third sector locations: A9-B10; A11-B12; C9-D10; and C11-D12;
(iv) one or more of fourth sector locations: E1-F2; E3-F4; G1-H2; and G3-H4;
(v) one or more of fifth sector locations: E5-F6; E7-F8; G5-H6; and G7-H8; and (vi) one or more of sixth sector locations: E9-F10; E11-F12; G9-H10; and G11-H12; and (b) said counter contacts are located at one or more of the following locations:
(i) one or more of first sector locations: A2-B3 and C2-D3;
(ii) one or more of second sector locations: A6-B7 and C6-D7;
(iii) one or more of third sector locations: A10-B11 and C10-D11;
(iv) one or more of fourth sector locations: E2-F3 and G2-H3;
(v) one or more of fifth sector locations:E6-F7 and G6-H7; and (vi) one or more of sixth sector locations: E10-F11 and G10-H11.
(i) one or more of first sector locations: A1-B2; A3-B4; C1-D2; and C3-D4;
(ii) one or more of second sector locations: A5-B6; A7-B8; C5-D6; and C7-D8;
(iii) one or more of third sector locations: A9-B10; A11-B12; C9-D10; and C11-D12;
(iv) one or more of fourth sector locations: E1-F2; E3-F4; G1-H2; and G3-H4;
(v) one or more of fifth sector locations: E5-F6; E7-F8; G5-H6; and G7-H8; and (vi) one or more of sixth sector locations: E9-F10; E11-F12; G9-H10; and G11-H12; and (b) said counter contacts are located at one or more of the following locations:
(i) one or more of first sector locations: A2-B3 and C2-D3;
(ii) one or more of second sector locations: A6-B7 and C6-D7;
(iii) one or more of third sector locations: A10-B11 and C10-D11;
(iv) one or more of fourth sector locations: E2-F3 and G2-H3;
(v) one or more of fifth sector locations:E6-F7 and G6-H7; and (vi) one or more of sixth sector locations: E10-F11 and G10-H11.
36. A multi-well plate having an array of wells corresponding to a 384-well plate configuration, said array comprising one or more of the following:
a first sector having wells A1 through A8, B1 through B8, C1 through C8, D1 through D8, E1 through E8, F1 through F8, G1 through G8, and H1 through H8;
-227-~
a second sector having wells A9 through A16, B9 through B16, C9 through C16, D9 through D16, E9 through E16, F9 through F16, G9 through G16, and H9 through H16;
a third sector having wells A17 through A24, B17 through B24, C17 through C24, D17 through D24, E17 through E24, F17 through F24, G17 through G24, and H17 through H24;
a fourth sector having wells I1 through I8, J1 through J8, K1 through K8, L1 through L8, M1 through M8, N1 through N8, O1 through O8 and P1 through P8;
a fifth sector having wells I9 through I16, J9 through J16, K9 through K16, L9 through L16, M9 through M16, N9 through N16, 09 through 016 and P9 through P16; and a sixth sector having wells I17 through I24, J17 through J24, K17 through K24, L17 through L24, M17 through M24, N17 through N24, O17 through 024 and P 17 through P24;
said multi-well plate having a plurality of electrodes on a top surface and a plurality of contact surfaces on a bottom surface, wherein said plurality of electrodes are electrically connected to said plurality of contact surfaces.
a first sector having wells A1 through A8, B1 through B8, C1 through C8, D1 through D8, E1 through E8, F1 through F8, G1 through G8, and H1 through H8;
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a second sector having wells A9 through A16, B9 through B16, C9 through C16, D9 through D16, E9 through E16, F9 through F16, G9 through G16, and H9 through H16;
a third sector having wells A17 through A24, B17 through B24, C17 through C24, D17 through D24, E17 through E24, F17 through F24, G17 through G24, and H17 through H24;
a fourth sector having wells I1 through I8, J1 through J8, K1 through K8, L1 through L8, M1 through M8, N1 through N8, O1 through O8 and P1 through P8;
a fifth sector having wells I9 through I16, J9 through J16, K9 through K16, L9 through L16, M9 through M16, N9 through N16, 09 through 016 and P9 through P16; and a sixth sector having wells I17 through I24, J17 through J24, K17 through K24, L17 through L24, M17 through M24, N17 through N24, O17 through 024 and P 17 through P24;
said multi-well plate having a plurality of electrodes on a top surface and a plurality of contact surfaces on a bottom surface, wherein said plurality of electrodes are electrically connected to said plurality of contact surfaces.
37. The multi-well plate of claim 36, wherein said plurality of contact surfaces are located between or adjacent said wells.
38. The multi-well plate of claim 36, wherein said plurality of electrodes comprise one or more working electrodes and one or more counter electrodes and said plurality of contact surfaces comprises one or more working contacts electrically connected to said one or more working electrodes and one or more counter contacts electrically connected to said one or more counter electrodes.~
39. The multi-well plate of claim 36, wherein said contact surfaces are located at one or more of the following locations:
(i) two or more of first sector locations: B2-C3; B4-C5; B6-C7;
F2-G3; F4-G5; F6-G7;
(ii) two or more of second sector locations: B10-C11; B12-C13;
B14-C15; F10-G11; F12-G13; F14 -G15;
(iii) two or more of third sector locations: B18-C19; B20-C21; B22-C23; F18-G19; F20-G21; F22-G23;
(iv) two or more of fourth sector locations: J2-K3; J4-K5; J6-K7;
N2-O3; N4-O5; N6-O7;
(v) two or more of fifth sector locations: J10-K11; J12-K13; J14-K15; N10-O11; N12-O13; N14-O15; and (vi) two or more of sixth sector locations: J18-K19; J20-K21; J22-K23; N18-O19; N20-O21; N22-O23.
(i) two or more of first sector locations: B2-C3; B4-C5; B6-C7;
F2-G3; F4-G5; F6-G7;
(ii) two or more of second sector locations: B10-C11; B12-C13;
B14-C15; F10-G11; F12-G13; F14 -G15;
(iii) two or more of third sector locations: B18-C19; B20-C21; B22-C23; F18-G19; F20-G21; F22-G23;
(iv) two or more of fourth sector locations: J2-K3; J4-K5; J6-K7;
N2-O3; N4-O5; N6-O7;
(v) two or more of fifth sector locations: J10-K11; J12-K13; J14-K15; N10-O11; N12-O13; N14-O15; and (vi) two or more of sixth sector locations: J18-K19; J20-K21; J22-K23; N18-O19; N20-O21; N22-O23.
40. The multi-well plate of claim 38, wherein (a) said working contacts are located at one or more of the following locations:
(i) ~one or more of first sector locations: B2-C3; B6-C7; F2-G3;
and F6-G7;
(ii) ~one or more of second sector locations: B10-C11; B14-C15;
F10-G11; and F14 -G15;
(iii) ~one or more of third sector locations: B18-C19; B22-C23; F18-G19; and F22-G23;
(iv) ~one or more of fourth sector locations: J2-K3; J6-K7; N2-O3;
and N6-O7;
(v) ~one or more of fifth sector locations: J10-K11; J14-K15; N10-O11; and N14-O15; and (vi) ~one or more of sixth sector locations: J18-K19; J22-K23; N18-O19; and N22-O23; and (b) said counter contacts are located at one or more of the following locations:
(i) ~one or more of first sector locations: B4-C5 and F4-G5;
(ii) ~one or more of second sector locations: B12-C13 and F12-G13;
(iii) ~one or more of third sector locations: B20-C21 and F20-G21;
(iv) ~one or more of fourth sector locations: J4-K5 and N4-O5;
(v) ~one or more of fifth sector locations: J12-K13 and N12-013;
and~
(vi) ~one or more of sixth sector locations: J20-K21 and N20-O21.
(i) ~one or more of first sector locations: B2-C3; B6-C7; F2-G3;
and F6-G7;
(ii) ~one or more of second sector locations: B10-C11; B14-C15;
F10-G11; and F14 -G15;
(iii) ~one or more of third sector locations: B18-C19; B22-C23; F18-G19; and F22-G23;
(iv) ~one or more of fourth sector locations: J2-K3; J6-K7; N2-O3;
and N6-O7;
(v) ~one or more of fifth sector locations: J10-K11; J14-K15; N10-O11; and N14-O15; and (vi) ~one or more of sixth sector locations: J18-K19; J22-K23; N18-O19; and N22-O23; and (b) said counter contacts are located at one or more of the following locations:
(i) ~one or more of first sector locations: B4-C5 and F4-G5;
(ii) ~one or more of second sector locations: B12-C13 and F12-G13;
(iii) ~one or more of third sector locations: B20-C21 and F20-G21;
(iv) ~one or more of fourth sector locations: J4-K5 and N4-O5;
(v) ~one or more of fifth sector locations: J12-K13 and N12-013;
and~
(vi) ~one or more of sixth sector locations: J20-K21 and N20-O21.
41. ~An assay module comprising a substrate having an 2x3 array of square sectors and having a plurality of electrodes on a top surface and a plurality of contact surfaces on a bottom surface, wherein said plurality of electrodes are electrically connected to said plurality of contact surfaces.
42. ~The assay module of claim 41, wherein said plurality of electrodes comprise one or more working electrodes and one or more counter electrodes and said plurality of contact surfaces comprises one or more working contacts electrically connected to said one or more working electrodes and one or more counter contacts electrically connected to said one or more counter electrodes.
43. ~The assay module of claim 41, wherein each sector comprises one or more electrical contacts located at one or more of the following locations (X, Y) measured (inches) from the top left corner of said substrate (right side up):
(i) ~two or more of first sector locations (inches, ~ 0.125"): (0.743, 0.620), (1.097, 0.620), (1.451, 0.620), (0.743, 1.329), (1.097,~
1.329), (1.451, 1.329);
(ii) ~two or more of second sector locations (inches, ~ 0.125"):
(2.161, 0.620), (2.515, 0.620), (2.869, 0.620), (2.161, 1.329), (2.515, 1.329), (2.869, 1.329);
(iii) ~two or more of third sector locations (inches, ~ 0.125"): (3.579, 0.620), (3.933, 0.620), (4.287, 0.620), (3.579, 1.329), (3.933, 1.329), (4.287, 1.329);
(iv) ~two or more of fourth sector locations (inches, ~ 0.125"):
(0.743, 2.038), (1.097, 2.038), (1.451, 2.038), (0.743, 2.747), (1.097, 2.747), (1.451, 2.747);
(v) ~two or more of fifth sector locations (inches, ~ 0.125"): (2.161, 2.038), (2.515, 2.038), (2.869, 2.038), (2.161, 2.747), (2.515, 2.747), (2.869, 2.747); and (vi) ~two or more of sixth sector locations (inches, ~ 0.125"): (3.579, 2.038), (3.933, 2.038), (4.287, 2.038), (3.579, 2.747), (3.933, 2.747), (4.287, 2.747).
(i) ~two or more of first sector locations (inches, ~ 0.125"): (0.743, 0.620), (1.097, 0.620), (1.451, 0.620), (0.743, 1.329), (1.097,~
1.329), (1.451, 1.329);
(ii) ~two or more of second sector locations (inches, ~ 0.125"):
(2.161, 0.620), (2.515, 0.620), (2.869, 0.620), (2.161, 1.329), (2.515, 1.329), (2.869, 1.329);
(iii) ~two or more of third sector locations (inches, ~ 0.125"): (3.579, 0.620), (3.933, 0.620), (4.287, 0.620), (3.579, 1.329), (3.933, 1.329), (4.287, 1.329);
(iv) ~two or more of fourth sector locations (inches, ~ 0.125"):
(0.743, 2.038), (1.097, 2.038), (1.451, 2.038), (0.743, 2.747), (1.097, 2.747), (1.451, 2.747);
(v) ~two or more of fifth sector locations (inches, ~ 0.125"): (2.161, 2.038), (2.515, 2.038), (2.869, 2.038), (2.161, 2.747), (2.515, 2.747), (2.869, 2.747); and (vi) ~two or more of sixth sector locations (inches, ~ 0.125"): (3.579, 2.038), (3.933, 2.038), (4.287, 2.038), (3.579, 2.747), (3.933, 2.747), (4.287, 2.747).
44. ~The assay module of claim 42, wherein (a) said working contacts are located at one or more of the following locations:
(i) ~one or more of first sector locations (inches, ~ 0.125"): (0.743, 0.620), (1.451, 0.620), ( 0.743, 1.329), and (1.451, 1.329);
(ii) one or more of second sector locations (inches, ~ 0.125"):
(2.161, 0.620), (2.869, 0.620), (2.161, 1.329), and (2.869, 1.329);
(iii) one or more of third sector locations (inches, ~ 0.125"):
(3.579, 0.620), (4.287, 0.620), (3.579, 1.329), and (4.287, 1.329);
(iv) one or more of fourth sector locations (inches, ~ 0.125"):
(0.743, 2.038), (1.451, 2.038), (0.743, 2.747), and (1.451, 2.747);
(v) ~one or more of fifth sector locations (inches, ~ 0.125"): (2.161, 2.038), (2.869, 2.038), (2.161, 2.747), and (2.869, 2.747);
and (vi) one or more of sixth sector locations (inches, ~ 0.125"):
(3.579, 2.038), (4.287, 2.038), (3.579, 2.747), and (4.287, 2.747); and (b) said counter contacts are located at one or more of the following locations:
(i) one or more of first sector locations (inches, ~ 0.125"): (1.097, 0.620) and (1.097, 1.329);
(ii) one or more of second sector locations (inches, ~ 0.125"):
(2.515, 0.620) and (2.515, 1.329);
(iii) one or more of third sector locations (inches, ~ 0.125"): (3.933, 0.620) and (3.933, 1.329);
(iv) one or more of fourth sector locations (inches, ~ 0.125"):
(1.097, 2.038) and (1.097, 2.747);
(v) one or more of fifth sector locations (inches, ~ 0.125"): (2.515, 2.038) and (2.515, 2.747); and (vi) one or more of sixth sector locations (inches, ~ 0.125"): (3.933, 2.038) and (3.933, 2.747).
(i) ~one or more of first sector locations (inches, ~ 0.125"): (0.743, 0.620), (1.451, 0.620), ( 0.743, 1.329), and (1.451, 1.329);
(ii) one or more of second sector locations (inches, ~ 0.125"):
(2.161, 0.620), (2.869, 0.620), (2.161, 1.329), and (2.869, 1.329);
(iii) one or more of third sector locations (inches, ~ 0.125"):
(3.579, 0.620), (4.287, 0.620), (3.579, 1.329), and (4.287, 1.329);
(iv) one or more of fourth sector locations (inches, ~ 0.125"):
(0.743, 2.038), (1.451, 2.038), (0.743, 2.747), and (1.451, 2.747);
(v) ~one or more of fifth sector locations (inches, ~ 0.125"): (2.161, 2.038), (2.869, 2.038), (2.161, 2.747), and (2.869, 2.747);
and (vi) one or more of sixth sector locations (inches, ~ 0.125"):
(3.579, 2.038), (4.287, 2.038), (3.579, 2.747), and (4.287, 2.747); and (b) said counter contacts are located at one or more of the following locations:
(i) one or more of first sector locations (inches, ~ 0.125"): (1.097, 0.620) and (1.097, 1.329);
(ii) one or more of second sector locations (inches, ~ 0.125"):
(2.515, 0.620) and (2.515, 1.329);
(iii) one or more of third sector locations (inches, ~ 0.125"): (3.933, 0.620) and (3.933, 1.329);
(iv) one or more of fourth sector locations (inches, ~ 0.125"):
(1.097, 2.038) and (1.097, 2.747);
(v) one or more of fifth sector locations (inches, ~ 0.125"): (2.515, 2.038) and (2.515, 2.747); and (vi) one or more of sixth sector locations (inches, ~ 0.125"): (3.933, 2.038) and (3.933, 2.747).
45. The assay module of claim 41, wherein said assay module is a multi-well plate having a plurality of wells.
46. A multi-well plate having a plurality of wells, wherein at least one well has a working electrode surface and a plurality of assay domains formed thereon.
47. The multi-well plate of claim 46, wherein at least two of said plurality of assay domains comprise different reagents.
48. The multi-well plate of claim 46, wherein said working electrode surface comprises at least four discrete assay domains formed thereon.
49. The multi-well plate of claim 46, wherein said assay domains are independently addressable.
50. A multi-well plate having a plurality of wells, wherein two or more wells have a plurality working electrode surfaces and each working electrode surface has one or more assay domains formed thereon.
51. A multi-well plate comprising a plate top having a plurality of wells, wherein each of said plurality of wells includes a well bottom having a working electrode surface and a counter electrode surface, wherein each well comprises a plastic well wall comprising from 4-20 wt% whitener.
52. A multi-well plate comprising:
(a) an electrically conductive layer;
(b) an insulating layer having a plurality of insulating layer openings; and (c) a plate top comprising an electrically conductive surface, said plate top having a plurality of plate top openings; wherein said insulating layer is between said electrically conductive layer and said plate top and said insulating layer openings and said plate top openings are aligned forming wells for conducting assays.
(a) an electrically conductive layer;
(b) an insulating layer having a plurality of insulating layer openings; and (c) a plate top comprising an electrically conductive surface, said plate top having a plurality of plate top openings; wherein said insulating layer is between said electrically conductive layer and said plate top and said insulating layer openings and said plate top openings are aligned forming wells for conducting assays.
53. A multi-well plate comprising:
(a) a substrate surface having a plurality of electrodes patterned thereon;
(b) an insulating layer having a plurality of insulating layer openings; and (c) a plate top comprising an electrically conductive surface, said plate top having a plurality of plate top openings;
wherein said insulating layer is between said substrate surface and said plate top and said insulating layer openings and said plate top openings are aligned forming plate openings over one or more of said plurality of electrodes thereby forming wells.
(a) a substrate surface having a plurality of electrodes patterned thereon;
(b) an insulating layer having a plurality of insulating layer openings; and (c) a plate top comprising an electrically conductive surface, said plate top having a plurality of plate top openings;
wherein said insulating layer is between said substrate surface and said plate top and said insulating layer openings and said plate top openings are aligned forming plate openings over one or more of said plurality of electrodes thereby forming wells.
54. A multi-well plate comprising:
(a) an electrically conductive layer partitioned into two or more electrically isolated sectors;
(b) an insulating layer having a plurality of insulating layer openings; and (c) a plate top comprising an electrically conductive surface, said plate top having a plurality of plate top openings;
wherein said insulating layer is between said electrically conductive layer and said plate top and said insulating layer openings and said plate top openings are aligned forming wells.
(a) an electrically conductive layer partitioned into two or more electrically isolated sectors;
(b) an insulating layer having a plurality of insulating layer openings; and (c) a plate top comprising an electrically conductive surface, said plate top having a plurality of plate top openings;
wherein said insulating layer is between said electrically conductive layer and said plate top and said insulating layer openings and said plate top openings are aligned forming wells.
55. A multi-well plate comprising:
(a) an electrically conductive layer;
(b) an insulating layer having a plurality of insulating layer openings; and (c) a plate top comprising an electrically conductive surface partitioned into two or more electrically isolated sectors, said plate top having a plurality of plate top openings;
wherein said insulating layer is between said electrically conductive layer and said plate top and said insulating layer openings and said plate top openings are aligned forming wells.
(a) an electrically conductive layer;
(b) an insulating layer having a plurality of insulating layer openings; and (c) a plate top comprising an electrically conductive surface partitioned into two or more electrically isolated sectors, said plate top having a plurality of plate top openings;
wherein said insulating layer is between said electrically conductive layer and said plate top and said insulating layer openings and said plate top openings are aligned forming wells.
56. A multi-well plate comprising:
(a) a first electrically conductive layer;
(b) an insulating layer having a plurality of insulating layer openings;
(c) a second electrically conductive layer on said insulating layer, said second electrically conductive layer having a plurality of second electrically conductive layer openings; and (a) a plate top having a plurality of plate top openings;
wherein said insulating layer is between said first electrically conductive layer and said plate top and wherein said insulating layer openings, said second electrically conductive layer openings and said plate top openings are aligned forming a plurality of wells.
(a) a first electrically conductive layer;
(b) an insulating layer having a plurality of insulating layer openings;
(c) a second electrically conductive layer on said insulating layer, said second electrically conductive layer having a plurality of second electrically conductive layer openings; and (a) a plate top having a plurality of plate top openings;
wherein said insulating layer is between said first electrically conductive layer and said plate top and wherein said insulating layer openings, said second electrically conductive layer openings and said plate top openings are aligned forming a plurality of wells.
57. A multi-well plate comprising:
(a) a substrate comprising partitioned electrically conductive surfaces;
(b) ~an insulating layer having a plurality of insulating layer openings;
(c) ~a second electrically conductive layer on said insulating layer, said second electrically conductive layer having a plurality of second electrically conductive layer openings; and (d) ~a plate top having a plurality of plate top openings;
wherein said insulating layer is between said substrate and said plate top and wherein said insulating layer openings, said second electrically conductive layer openings and said plate top openings are aligned forming wells.
(a) a substrate comprising partitioned electrically conductive surfaces;
(b) ~an insulating layer having a plurality of insulating layer openings;
(c) ~a second electrically conductive layer on said insulating layer, said second electrically conductive layer having a plurality of second electrically conductive layer openings; and (d) ~a plate top having a plurality of plate top openings;
wherein said insulating layer is between said substrate and said plate top and wherein said insulating layer openings, said second electrically conductive layer openings and said plate top openings are aligned forming wells.
58. ~A multi-well plate comprising:
(a) a substrate comprising one or more electrically conductive surfaces;
(b) an insulating layer having a plurality of insulating layer openings;
(c) a partitioned second electrically conductive layer on said insulating layer having a plurality of second electrically conductive layer openings; and (d) a plate top having a plurality of plate top openings wherein said insulating layer is between said substrate and said plate top and wherein said layer openings, said partitioned second electrically conductive layer openings and said plate top openings are aligned forming wells.
(a) a substrate comprising one or more electrically conductive surfaces;
(b) an insulating layer having a plurality of insulating layer openings;
(c) a partitioned second electrically conductive layer on said insulating layer having a plurality of second electrically conductive layer openings; and (d) a plate top having a plurality of plate top openings wherein said insulating layer is between said substrate and said plate top and wherein said layer openings, said partitioned second electrically conductive layer openings and said plate top openings are aligned forming wells.
59. ~A multi-well plate comprising:
(a) ~a first electrically conductive layer partitioned into two or more electrically isolated sectors;
(b) ~an insulating layer having a plurality of insulating layer openings;
(c) ~a second electrically conductive layer on said insulating layer having a plurality of second electrically conductive layer openings; and (d) ~a plate top having a plurality of plate top openings;
wherein said insulating layer is between said first electrically conductive layer and said plate top and wherein said insulating layer openings, said second electrically conductive layer openings and said plate top openings are aligned forming wells and wherein said two or more electrically isolated sectors are aligned with said plate top openings thereby forming independently addressable sectors of jointly addressable wells.
(a) ~a first electrically conductive layer partitioned into two or more electrically isolated sectors;
(b) ~an insulating layer having a plurality of insulating layer openings;
(c) ~a second electrically conductive layer on said insulating layer having a plurality of second electrically conductive layer openings; and (d) ~a plate top having a plurality of plate top openings;
wherein said insulating layer is between said first electrically conductive layer and said plate top and wherein said insulating layer openings, said second electrically conductive layer openings and said plate top openings are aligned forming wells and wherein said two or more electrically isolated sectors are aligned with said plate top openings thereby forming independently addressable sectors of jointly addressable wells.
60. A multi-well plate for conducting electrode induced luminescence assays comprising:
(a) a first electrically conductive layer;
(b) an insulating layer having a plurality of insulating layer openings;
(c) a second electrically conductive layer on said insulating layer having a plurality of second electrically conductive layer openings, said conductive film being partitioned into two or more electrically isolated sectors; and (d) a plate top having a plurality of plate top openings;
wherein said insulating layer is between said first electrically conductive layer and plate top and wherein said insulating layer openings, said second electrically conductive layer openings and said plate top openings are aligned forming wells for conducting said electrode induced luminescence assays.
(a) a first electrically conductive layer;
(b) an insulating layer having a plurality of insulating layer openings;
(c) a second electrically conductive layer on said insulating layer having a plurality of second electrically conductive layer openings, said conductive film being partitioned into two or more electrically isolated sectors; and (d) a plate top having a plurality of plate top openings;
wherein said insulating layer is between said first electrically conductive layer and plate top and wherein said insulating layer openings, said second electrically conductive layer openings and said plate top openings are aligned forming wells for conducting said electrode induced luminescence assays.
61. ~A multi-well plate for conducting electrode induced luminescence assays comprising:
(a) ~a first electrically conductive layer partitioned into two or more electrically isolated sectors;
(b) ~an insulating layer having a plurality of insulating layer openings;
(c) ~a second electrically conductive layer on said insulating layer having a plurality of second electrically conductive layer openings, said conductive film being partitioned into two or more electrically isolated sectors; and (d) ~a plate top having a plurality of plate top openings;
wherein said insulating layer is between said first electrically conductive layer and plate top and wherein said insulating layer openings, said second electrically conductive layer openings and said plate top openings are aligned forming wells for conducting said electrode induced luminescence assays.
(a) ~a first electrically conductive layer partitioned into two or more electrically isolated sectors;
(b) ~an insulating layer having a plurality of insulating layer openings;
(c) ~a second electrically conductive layer on said insulating layer having a plurality of second electrically conductive layer openings, said conductive film being partitioned into two or more electrically isolated sectors; and (d) ~a plate top having a plurality of plate top openings;
wherein said insulating layer is between said first electrically conductive layer and plate top and wherein said insulating layer openings, said second electrically conductive layer openings and said plate top openings are aligned forming wells for conducting said electrode induced luminescence assays.
62. ~A multi-well plate having a plurality of wells, wherein two or more of said plurality of wells each comprise a working electrode surface formed by applying one or more layers of carbon onto a conductive layer comprising silver.
63. ~The multi-well plate of claim 62, wherein said one or more layers of carbon completely covers said conductive layer.
64. ~A multi-well plate bottom comprising:
(a) ~a substrate having a top surface and a bottom surface;
(b) ~a plurality of patterned working electrodes on said top surface;
-235-~
(c) a plurality of patterned counter electrodes on said top surface, each of said patterned counter electrodes being associated with corresponding patterned working electrodes; and (d) two or more independently addressable sectors, each sector having two or more independently addressable contacts on said bottom surface, each of said contacts corresponding to one or more electrodes within wells within one of said sectors.~
(a) ~a substrate having a top surface and a bottom surface;
(b) ~a plurality of patterned working electrodes on said top surface;
-235-~
(c) a plurality of patterned counter electrodes on said top surface, each of said patterned counter electrodes being associated with corresponding patterned working electrodes; and (d) two or more independently addressable sectors, each sector having two or more independently addressable contacts on said bottom surface, each of said contacts corresponding to one or more electrodes within wells within one of said sectors.~
65. A multi-well plate bottom comprising:
(a) a substrate having a top surface and a bottom surface;
(b) a plurality of patterned working electrodes on said top surface;
(c) a plurality of patterned counter electrodes on said top surface, each of said patterned counter electrodes being associated with corresponding patterned working electrodes; and (d) two or more independently addressable contact sectors on said bottom surface, each of said contact sectors corresponding to an electrode sector comprising one or more of said plurality of patterned working electrodes and one or more of said plurality of patterned counter electrodes on said top surface and including a plurality of conductive contact surfaces.
wherein said plurality of conductive contact surfaces include:
(i) a first conductive contact surface located within a first contact region, said first conductive contact surface being electrically connected to said one or more corresponding patterned working electrodes on said top surface; and (ii) a second conductive contact surface located within a second contact region, said second conductive contact surface being electrically connected to said one or more corresponding patterned counter electrodes on said top surface;
(iii) wherein said first conductive contact surface and said second conductive contact surface are electrically isolated from each other.
(a) a substrate having a top surface and a bottom surface;
(b) a plurality of patterned working electrodes on said top surface;
(c) a plurality of patterned counter electrodes on said top surface, each of said patterned counter electrodes being associated with corresponding patterned working electrodes; and (d) two or more independently addressable contact sectors on said bottom surface, each of said contact sectors corresponding to an electrode sector comprising one or more of said plurality of patterned working electrodes and one or more of said plurality of patterned counter electrodes on said top surface and including a plurality of conductive contact surfaces.
wherein said plurality of conductive contact surfaces include:
(i) a first conductive contact surface located within a first contact region, said first conductive contact surface being electrically connected to said one or more corresponding patterned working electrodes on said top surface; and (ii) a second conductive contact surface located within a second contact region, said second conductive contact surface being electrically connected to said one or more corresponding patterned counter electrodes on said top surface;
(iii) wherein said first conductive contact surface and said second conductive contact surface are electrically isolated from each other.
66. A multi-well plate comprising the plate bottom of claims 64 or 65, and a plate top affixed on said top surface of said plate bottom forming said multi-well plate.
67. A method of making the multi-well plate for use in luminescence assays comprising:
(a) forming at least one conductive layer having one or more electrodes;
(b) forming at least one dielectric layer onto said at least one conductive layer forming a plurality of dielectric layer openings thereon; and (c) affixing a plate top having a plurality of plate top openings onto said dielectric layer;
wherein said dielectric layer openings and said plate top openings are aligned to form said plurality of wells.
(a) forming at least one conductive layer having one or more electrodes;
(b) forming at least one dielectric layer onto said at least one conductive layer forming a plurality of dielectric layer openings thereon; and (c) affixing a plate top having a plurality of plate top openings onto said dielectric layer;
wherein said dielectric layer openings and said plate top openings are aligned to form said plurality of wells.
68. The method of claim 67, wherein said at least one conductive layer further forms one or more working electrodes.
69. The method of claim 67, wherein said at least one conductive layer further forms one or more counter electrodes.
70. The method of claim 67, wherein said plate top comprises one or more conductive surfaces forming one or more counter electrodes.
71. The method of claim 67, further comprising the step of applying one or more conductive surfaces onto said dielectric layer forming one or more counter electrodes.
72. The method of claim 67, wherein said at least one conductive layer is applied by screen printing.
73. An assay module for conducting luminescence assays comprising a substrate, wherein said substrate comprises independently addressable sectors of jointly addressable electrodes patterned thereon.
74. An assay module comprising a substrate having one or more fluid channels for introducing samples and/or assay reagents and one or more working electrode surfaces and one or more counter electrode surfaces on said substrate, wherein said working electrode comprises a carbon ink.
75. An assay module comprising a working electrode surface and a counter electrode surface, wherein said working electrode surface and said counter electrode surface comprise a printed conductive material.
76. An assay module comprising a working electrode surface and a counter electrode surface, wherein said working electrode surface and said counter electrode surface comprise a conductive material applied in liquid form.
77. An assay module comprising a working electrode surface and a counter electrode surface, wherein said working electrode surface comprises carbon and said counter electrode surface comprises a metal.
78. The assay module of claim 77, wherein said metal comprises aluminum, silver or nickel.
79. The assay module of claim 77, wherein said counter electrode surface comprises aluminum.
80. An assay module comprising a working electrode surface and a counter electrode surface, wherein said counter electrode surface comprises a metal on an adhesive layer.
81. The assay module of claim 80, wherein said metal comprises aluminum, silver or nickel.
82. The assay module of claim 80, wherein said metal comprises aluminum.
83. An assay module having one or more assay regions, said assay regions comprising one or more working electrode surfaces and one or more counter electrode surfaces, wherein the surface ratio of said one or more working electrode surfaces to said one or more counter electrode surfaces is at least 2 to 1.
84. An assay module comprising a printed working electrode surface and a plurality of assay domains formed thereon.
85. The assay module of claim 84, wherein at least two of said plurality of assay domains comprise different binding reagents.
86. An assay module comprising a working electrode surface formed by applying one or more layers of carbon onto a conductive layer comprising silver thereby forming said assay module.
87. The assay module of claim 86, wherein said one or more layers of carbon completely covers said conductive layer.
88. A method of making an assay module comprising patterning a metal-containing material onto a substrate forming a patterned conductive metal-containing surface on said substrate and subsequently applying a carbon-containing material onto said patterned conductive metal-containing surface forming a patterned electrode surface.
89. The method of claim 88, wherein said carbon-containing material covers said patterned conductive metal-containing surface.
90. The method of claim 89, further comprising immobilizing one or more reagents onto said patterned electrode surface.
91. The method of claim 89, wherein said metal-containing material comprises silver.
92. A method for measuring luminescence from the multi-well assay plate of any one of claims 1-40 or 46-63, comprising providing electrical energy to said wells in sectors, inducing luminescence in sectors, measuring said luminescence in sectors or combinations thereof.
93. A system for conducting an assay comprising an assay apparatus and the multi-well assay plate of any one of claims 1-40 or 46-63.
94. A system for conducting a luminescence assay comprising a luminescence apparatus and the multi-well assay plate of any one of claims 1-40 or 46-63.
95. A system for conducting an electrode induced luminescence assay comprising the multi-well assay plate of any one of claims 1-40 or 46-63 and an apparatus for inducing and measuring luminescence from said plate.
96. A kit for use in conducting electrode induced luminescence assays comprising, in one or more containers, a multi-well assay plate and at least one assay component selected from the group consisting of: (a) at least one luminescent label;
(b) at least one electrochemiluminescence coreactant; (c) one or more binding reagents; (d) a pH buffer; (e) one or more blocking reagents; (f) preservatives; (g) stabilizing agents; (h) enzymes; (i) detergents; and (j) desiccants.
(b) at least one electrochemiluminescence coreactant; (c) one or more binding reagents; (d) a pH buffer; (e) one or more blocking reagents; (f) preservatives; (g) stabilizing agents; (h) enzymes; (i) detergents; and (j) desiccants.
97. The kit of claim 96, wherein at least one assay component is immobilized within said wells.
98. The kit of any one of claims 96 or 97, wherein at least one assay component is dried within said wells.
99. The kit of any one of claims 96-98, wherein said multi-well plate is adapted for use in conducting said electrode induced luminescence assays in sectors.
100. The kit of any one of claims 96-99, wherein said plurality of wells include at least two different bioreagents.
101. A kit for use in conducting electrode induced luminescence assays comprising: (i) the multi-well assay plate of any one of claims 1-40 or 46-63 or the assay module of any of claims 41 or 73-87 and (ii) at least one assay component selected from the group consisting of: (a) at least one luminescent label; and (b) at least one electrochemiluminescence coreactant.
102. The kit of claim 101, wherein said wells include at least two different bioreagents.
103. A kit for use in conducting electrode induced luminescence assays comprising a multi-well assay plate having a plurality of wells and at least one assay component selected from the group consisting of: (a) at least one luminescent label;
(b) at least one electro-chemiluminescence coreactant; (c) one or more binding reagents; (d) a pH buffer; (e) one or more blocking agents;
(f) preservatives; (g) stabilizing agents; (h) enzymes; (i) detergents; (j) standards and (k) desiccants.
(b) at least one electro-chemiluminescence coreactant; (c) one or more binding reagents; (d) a pH buffer; (e) one or more blocking agents;
(f) preservatives; (g) stabilizing agents; (h) enzymes; (i) detergents; (j) standards and (k) desiccants.
104. The kit of claim 103, wherein at least one assay component is immobilized within said wells.
105. The kit of any one of claims 103-104, wherein at least one assay component is dried within said wells.
106. The kit of any one of claims 103-105, wherein said multi-well plate is adapted for use in conducting said electrode induced luminescence assays in sectors.
107. The kit of any one of claims 103-106, wherein said plurality of wells include at least two different bioreagents.
108. The kit of any one of claims 103-107, wherein all assay components are dried within said wells.
109. The assay module of any one of claims 41-45 or 73-91, wherein said assay module further has a plurality of wells.
110. The assay module of any one of claims 41-45 or 73-91, wherein said assay module further has one or more fluidic channels.
111. The multi-well plate of any one of claims 1-30 or 46-63, wherein said multi-well assay plate is a standard multi-well assay plate.
112. The multi-well plate of any one of claims 1-30 or 46-63, wherein said multi-well assay plate is a 2 well plate, 6 well plate, 24 well plate, 96 well plate, 384 well plate, 1536 well plate, 6144 well plate or 9600 well plate.
113. The multi-well plate of any one of claims 2-21, 25-30, 46 or 50, wherein said plurality of wells comprise rows and columns of wells.
114. The multi-well plate of any one of claims 2-21, 25-30, 46 or 50, wherein said plurality of wells comprise an array of wells including rows and columns.
115. The multi-well plate of any one of claims 2-21, 25-30, 46 or 50-51, wherein said plurality of wells are electrically addressable in sectors.
116. The multi-well plate of any one of claims 2-21, 25-30, 46 or 50-51, wherein said plate comprises a plurality of independently addressable sectors comprising two or more wells.
117. The multi-well plate of any one of claims 2-21, 25-30, 46 or 50-51, wherein said plate comprises a plurality of independently addressable sectors comprising a plurality of wells.
118. The multi-well plate of any one of claims 2-21, 25-30, 46 or 50-51, wherein said plate comprises a plurality of independently addressable sectors, two or more of said sectors comprising two or more wells.
119. The multi-well plate of any one of claims 2-21, 25-30, 46 or 50-51, wherein said plurality of wells are partitioned into separately addressable sectors.
120. The multi-well plate of any one of claims 115-119, wherein said sectors include more than one well and less than 50% of said plurality of wells.
121. The multi-well plate of any one of claims 115-119, wherein said sectors include more than one well and less than 40% of said plurality of wells.
122. The multi-well plate of any one of claims 115-119, wherein said sectors include more than one well and less than 30% of said plurality of wells.
123. The multi-well plate of any one of claims 115-119, wherein said sectors include more than one well and less than 20% of said plurality of wells.
124. The multi-well plate of any one of claims 115-119, wherein said sectors include more than one well and less than 15% of said plurality of wells.
125. The multi-well plate of any one of claims 115-119, wherein said sectors include more than one well and less than 10% of said plurality of wells.
126. The multi-well plate of any one of claims 115-119, wherein said sectors include more than one well and less than 5% of said plurality of wells.
127. The multi-well plate of any one of claims 115-119, wherein said sectors comprise a sub-array of said plurality of wells.
12g. The multi-well plate of any one of claims 1 or 115-119, wherein said sectors comprise a 4 x 4 array of said wells.
129. The multi-well plate of any one of claims 1 or 115-119, wherein said plate comprises a 2x3 array of sectors.
130. The multi-well plate of any one of claims 2-21, 25-30, 46 or 50-51, wherein said plate comprises six sectors, each sector having a 4 x 4 array of said plurality of wells.
131. The multi-well plate of any one of claims 1 or 115-119, wherein said sectors comprise one or more rows or one or more columns of said wells.
132. The multi-well plate of any one of claims 1 or 115-119, wherein said sectors comprise a row or column of said plurality of wells.
133. The multi-well plate of any one of claims 1 or 115-119, wherein said sectors comprise jointly addressable rows or columns of wells.
134. The multi-well plate of any one of claims 1 or 115-119, wherein said plate comprises an array of overlapping sectors, each sector comprising alternating members of a row and/or a column of said plurality of wells.
135. The multi-well plate of any one of claims 1 or 115-119, wherein said plate comprises segmented rows and/or segmented columns, said segmented rows or segmented columns comprising alternating wells and at least two sectors are overlapping on said plate.
136. The multi-well plate of any one of claims 1 or 115-119, wherein said sectors comprise one or more electrically connected electrodes.
137. The multi-well plate of claim 15, 53 or 66, wherein said two or more of said working electrodes axe jointly addressable.
138. The multi-well plate of any one of claims 1-24, further comprising a plurality of independently addressable sectors of jointly addressable wells on said plate, wherein said plate further comprises a bottom surface comprising at least two electrical contact surfaces electrically connected to said plurality of independently addressable sectors of jointly addressable wells.
139. The multi-well plate of claim 3, 4, 5, 8, 30, or 51, wherein said working electrode surface and said counter electrode surface are at the same vertical height within said wells.
140. The multi-well plate of claim 3, 4, 5, 8, 30, or 51, wherein the average spacing between said working electrode surface and said counter electrode surface is less than 0.1 inches.
141. The multi-well plate of claim 3, 4, 5, 8, 30, or 51, wherein the average spacing between said working electrode surface and said counter electrode surface is less than 0.05 inches.
142. The multi-well plate of claim 3, 4, 5, 8, 30, or 51, wherein the average spacing between said working electrode surface and said counter electrode surface is less than 0.01 inches.
143. The multi-well plate of claim 1, 21, 53, or 66, wherein said electrodes comprise carbon.
144. The multi-well plate of claim 1, 21, 53, or 66, wherein said electrodes comprise a carbon layer on a silver layer.
145. The multi-well plate of claim 1, 21, 53, or 66, wherein said electrodes comprise carbon particles.
146. The multi-well plate of claim 1, 21, 53, or 66, wherein said electrodes comprise carbon fibrils or carbon black.
147. The multi-well plate of claim 1, 21, 53, or 66, wherein said electrodes comprise carbon fibrils.
148. The multi-well plate of claim 1, 21, 53, or 66, wherein said electrodes comprise a carbon ink.
149. The multi-well plate of claim 1, 21, 53, or 66, wherein said electrodes comprise a printed conductive material.
150. The multi-well plate of claim 1, 21, 53, or 66, wherein said electrodes comprise a conductive material applied in liquid form.
151. The multi-well plate of claim 1, 53, or 66, wherein one or more of said electrodes comprise electrodes having a plurality of assay domains formed thereon.
152. The multi-well plate of claim 21, 50, or 151, wherein said plurality of assay domains comprises at least four assay domains.
153. The multi-well plate of claim 21, 50, or 151, wherein said plurality of assay domains comprises at least seven assay domains.
154. The multi-well plate of claim 21, 50, or 151, wherein said plurality of assay domains comprises at least ten assay domains.
155. The assay module of claim 21, 50, or 151, wherein said plurality of assay domains comprises at least twenty-five assay domains.
156. The multi-well plate of claim 21, 50, or 151, wherein said assay domains comprise immobilized reagents.
157. The multi-well plate of any one of claims 151-156, wherein said assay domains comprise one or more immobilized reagents selected from: antibodies, fragments of antibodies, proteins, enzymes, enzyme substrates, inhibitors, cofactors, antigens, haptens, lipoproteins, liposaccharides, cells, sub-cellular components, cell receptors, viruses, nucleic acids, antigens, lipids, glycoproteins, carbohydrates, peptides, amino acids, hormones, protein-binding ligands, pharmacological agents, luminescent labels or combinations thereof.
158. The multi-well plate of claim 156 or 157, wherein said immobilized reagents comprise proteins, nucleic acids, or combinations thereof.
159. The multi-well plate of any one of claims 1, 15, 31, 36, 53, or 66, wherein one or more of said electrodes have surfaces defined by a plurality of fluid containment regions, said containment regions comprising a plurality of different reagents for conducting multiple measurements in one well.
160. The multi-well plate of claim 159, wherein the surfaces defined by said plurality of fluid containment regions comprise plurality of different reagents for conducting multiple assays in one well.
161. The multi-well plate of claim 159, wherein said plurality of fluid containment regions are defined by holes in one or more dielectric layers on said electrodes.
162. The multi-well plate of any one of claims 2, 11 or 17, wherein said first electrode surface comprises carbon.
163. The multi-well plate of any one of claims 2, 11 or 17, wherein said first electrode surface comprises a carbon layer on a silver layer.
164. The multi-well plate of any one of claims 2, 11 or 17, wherein said first electrode surface comprises carbon particles.
165. The multi-well plate of any one of claims 2, 11 or 17, wherein said first electrode surface comprises carbon fibrils or carbon black.
166. The multi-well plate of any one of claims 2, 11 or 17, wherein said first electrode surface comprises carbon fibrils.
167. The multi-well plate of any one of claims 2, 11 or 17, wherein said first electrode surface comprises a carbon ink.
168. The multi-well plate of any one of claims 2, 11 or 17, wherein said first electrode surface comprises a printed conductive material.
169. The multi-well plate of any one of claims 2, 11 or 17, wherein said first electrode surface comprises a conductive material applied in liquid form.
170. The multi-well plate of any one of claims 2 or 17, wherein said first electrode surface is centered at the well bottom.
171. The multi-well plate of any one of claims 2, 11 or 17, wherein said first electrode surface comprises one or more binding reagents immobilized thereon.
172. The multi-well plate of any one of claims 2, 11 or 17, wherein said first electrode surface comprises electrodes having a plurality of assay domains formed thereon.
173. The multi-well plate of any one of claims 2, 11 or 17, wherein said second electrode surface comprises a metal.
174. The multi-well plate of any one of claims 2, 11 or 17, wherein said second electrode surface comprises a metal selected from silver, aluminum or nickel.
175. The multi-well plate of any one of claims 2, 11 or 17, wherein said second electrode surface comprises aluminum.
176. The multi-well plate of any one of claims 2, 11 or 17, wherein said second electrode surface comprises carbon.
177. The multi-well plate of any one of claims 3, 4, 8, 18, 25, 30, 46, or 51, wherein said working electrode surface comprises carbon.
178. The multi-well plate of any one of claims 3, 4, 5, 8, 18, 25, 30, 46, or 51, wherein said working electrode surface comprises a carbon layer on a silver layer.
179. The multi-well plate of any one of claims 3, 4, 5, 8, 18, 25, 30, 46, 51 or 62, wherein said working electrode surface comprises carbon particles.
180. The multi-well plate of any one of claims 3, 4, 5, 8, 18, 25, 30, 46, 51 or 62, wherein said working electrode surface comprises carbon fibrils or carbon black.
181. The multi-well plate of any one of claims 3, 4, 5, 8, 18, 25, 30, 46, 51 or 62, wherein said working electrode surface comprises carbon fibrils.
182. The multi-well plate of any one of claims 3, 4, 5, 8, 18, 25, 30, 46, 51 or 62, wherein said working electrode surface comprises carbon ink.
183. The multi-well plate of any one of claims 3, 4, 5, 8, 18, 25, 30, 46, 51 or 62, wherein said working electrode surface comprises a printed conductive material.
184. The multi-well plate of any one of claims 3, 4, 5, 8, 18, 25, 30, 46, 51 or 62, wherein said working electrode surface comprises a conductive material applied in liquid form.
185. The multi-well plate of any one of claims 3, 4, 5, 8, 18, 25, 30, 46, 51 or 62, wherein said working electrode surface is located at the center of the well bottom.
186. The multi-well plate of any one of claims 3, 4, 5, 8, 18, 25, 30, 46, 51 or 62, wherein said working electrode surface comprises one or more binding reagents immobilized thereon.
187. The multi-well plate of any one of claims 3, 4, 5, 8, 18, 25, 30, 46, 51 or 62, wherein said working electrode surface comprises electrodes having a plurality of assay domains formed thereon.
188. The multi-well plate of claim 187, wherein said plurality of assay domains comprises at least four assay domains.
189. The multi-well plate of claim 187 or 188, wherein said assay domains comprise immobilized reagents.
190. The multi-well plate of claim 187 or 188, wherein said assay domains comprise one or more immobilized reagents selected from: antibodies, fragments of antibodies, proteins, enzymes, enzyme substrates, inhibitors, cofactors, antigens, haptens, lipoproteins, liposaccharides, cells, sub-cellular components, cell receptors, viruses, nucleic acids, antigens, lipids, glycoproteins, carbohydrates, peptides, amino acids, hormones, protein-binding ligands, pharmacological agents, luminescent labels or combinations thereof.
191. The multi-well plate of claim 190, wherein said immobilized reagents comprise proteins, nucleic acids, or combinations thereof.
192. The multi-well plate of any one of claims 3, 4, 5, 8, 18, 25, 30, 46, 51 or 62, wherein said working electrode surface comprises surfaces defined by a plurality of fluid containment regions, said containment regions comprising a plurality of different reagents for conducting multiple measurements in one well.
193. The multi-well plate of claim 192, wherein the surfaces defined by said plurality of fluid containment regions comprise plurality of different reagents for conducting multiple assays in one well.
194. The multi-well plate of claim 192, wherein said plurality of fluid containment regions are defined by holes in one or more dielectric layers on said working electrode surface.
195. The multi-well plate of any one of claims 12, 17, or 21, wherein said working electrode comprises carbon.
196. The multi-well plate of any one of claims 12, 17, or 21, wherein said working electrode comprises a carbon layer on a silver layer.
197. The multi-well plate of any one of claims 12, 17, or 21, wherein said working electrode comprises carbon particles.
198. The multi-well plate of any one of claims 12, 17, or 21, wherein said working electrode comprises carbon fibrils or carbon black.
199. The multi-well plate of any one of claims 12, 17, or 21, wherein said working electrode comprises carbon fibrils.
200. The multi-well plate of any one of claims 12, 17, or 21, wherein said working electrode is located at the center of the well bottom.
201. The multi-well plate of any one of claims 12, 17, or 21, wherein said working electrode comprises one or more binding reagents immobilized thereon.
202. The multi-well plate of any one of claims 12, 17, or 21, wherein said working electrode comprises electrodes having a plurality of assay domains formed thereon.
203. The multi-well plate of any one of claims 56, 59, 60, or 61, wherein said first electrically conductive layer comprises carbon.
204. The multi-well plate of any one of claims 56, 59, 60, or 61, wherein said first electrically conductive layer comprises a carbon layer on a silver layer.
205. The multi-well plate of any one of claims 56, 59, 60, or 61, wherein said first electrically conductive layer comprises carbon particles.
206. The multi-well plate of any one of claims 56, 59, 60, or 61, wherein said first electrically conductive layer comprises carbon fibrils or carbon black.
207. The multi-well plate of any one of claims 56, 59, 60, or 61, wherein said first electrically conductive layer comprises carbon fibrils.
208. The multi-well plate of any one of claims 56, 59, 60, or 61, wherein said first electrically conductive layer is located at the center of the well bottom.
209. The multi-well plate of any one of claims 56, 59, 60, or 61, wherein said first electrically conductive layer comprises one or more binding reagents immobilized thereon.
210. The multi-well plate of any one of claims 56, 59, 60, or 61, wherein said first electrically conductive layer comprises one or more assay domains.
211. The multi-well plate of any one of claims 56, 59, 60, or 61, wherein said assay domains comprise one or more immobilized reagents selected from:
antibodies, fragments of antibodies, proteins, enzymes, enzyme substrates, inhibitors, cofactors, antigens, haptens, lipoproteins, liposaccharides, cells, sub-cellular components, cell receptors, viruses, nucleic acids, antigens, lipids, glycoproteins, carbohydrates, peptides, amino acids, hormones, protein-binding ligands, pharmacological agents, luminescent labels or combinations thereof.
antibodies, fragments of antibodies, proteins, enzymes, enzyme substrates, inhibitors, cofactors, antigens, haptens, lipoproteins, liposaccharides, cells, sub-cellular components, cell receptors, viruses, nucleic acids, antigens, lipids, glycoproteins, carbohydrates, peptides, amino acids, hormones, protein-binding ligands, pharmacological agents, luminescent labels or combinations thereof.
212. The multi-well plate of any one of claims 56, 59, 60, or 61, wherein said immobilized reagents comprise proteins, nucleic acids, or combinations thereof.
213. The multi-well plate of claim 57 or 58, wherein said electrically conductive surfaces comprise carbon.
214. The multi-well plate of claim 57 or 58, wherein said electrically conductive surfaces comprise a carbon layer on a silver layer.
215. The multi-well plate of claim 57 or 58, wherein said electrically conductive surfaces comprise carbon particles.
216. The multi-well plate of any one of claims 3-8, 18, 30, or 51, wherein said counter electrode surface comprises carbon.
217. The multi-well plate of any one of claims 3-8, 18, 30, or 51, wherein said counter electrode surface comprises a carbon layer on a silver layer.
218. The multi-well plate of any one of claims 3-8, 18, 30, or 51, wherein said counter electrode surface comprises carbon particles.
219. The multi-well plate of any one of claims 3-8, 18, 30, or 51, wherein said counter electrode surface comprises carbon fibrils or carbon black.
220. The multi-well plate of any one of claims 3-4, 18, 30, or 51, wherein said counter electrode surface comprises a metal.
221. The multi-well plate of any one of claims 3-4, 18, 30, or 51, wherein said counter electrode surface comprises a metal selected from the group consisting of silver, niclcel, or aluminum.
222. The multi-well plate of any one of claims 3-4, 18, 30, or 51, wherein said counter electrode surface comprises aluminum.
223. The multi-well plate of any one of claims 3-8, 18, 30, or 51, wherein said counter conductive surface is located at the periphery of said wells.
224. The multi-well plate of claim 18 or 20, wherein said dielectric surface is substantially free of silicon and silicone.
225. The multi-well plate of claim 18 or 20, wherein said dielectric surface comprises liquids, gels, solids or particulate materials dispersed in a matrix.
226. The multi-well plate of claim 18 or 20, wherein said dielectric surface comprises polymers, photoresists, plastics, adhesives, gels, glasses, non-conducting inks, non-conducting pastes, ceramics, papers, elastomers, silicones, thermoplastics or combinations thereof.
227. The multi-well plate of claim 18 or 20, wherein said dielectric surface comprises dielectric ink, a polymeric film, a photoresist film, a ceramic, glass film or combinations thereof.
228. The multi-well plate of claim 18 or 20, wherein said dielectric surface comprises non-conductive plastic, glass or ceramic.
229. The multi-well plate of any one of claims 3, 4, 5, 8, 18, 25, 30, 46, 51 or 62, further comprising a dielectric layer defining a plurality of fluid containment regions for confining fluids on said working electrode surface.
230. The multi-well plate of claim 12 or 17, further comprising a dielectric layer, said dielectric layer defining a plurality of fluid containment regions for confining fluids on said working electrode.
231. The multi-well plate of claim 1 or 66, wherein said plate bottom comprises a plastic.
232. The multi-well plate of claim 1 or 66, wherein said plate bottom comprises conductive particles incorporated into or on said plastic.
233. The multi-well plate of claim 1 or 66, wherein said plate bottom comprises carbon particles incorporated into or on said plastic.
234. The multi-well plate of claim 1 or 66, wherein said plate bottom comprises carbon fibrils incorporated into or on said plastic.
235. The multi-well plate of claim 1 or 66, wherein said plate bottom is substantially free of silicon and silicone.
236. The multi-well plate of claim 1 or 66, wherein said plate bottom comprises a porous material.
237. The multi-well plate of claim 236, wherein said porous material is a filter.
238. The multi-well plate of claim 22, 23, 53, 57, 58 or 66, wherein said plate top is sealed to said substrate using an adhesive.
239. The multi-well plate of claim 238, wherein said adhesive is substantially free of silicone.
240. The multi-well plate of any one of claims 22, 23, 25, 26, 30, 53, 57, 58, 64, or 65, wherein said substrate comprises a plastic.
241. The multi-well plate of any one of claims 22, 23, 25, 26, 30, 53, 57, 58, 64, or 65, wherein said substrate comprises metal particles incorporated into or on said plastic.
242. The multi-well plate of any one of claims 22, 23, 25, 26, 30, 53, 57, 58, 64, or 65, wherein said substrate comprises carbon particles incorporated into or on said plastic.
243. The multi-well plate of any one of claims 22, 23, 25, 26, 30, 53, 57, 58, 64, or 65, wherein said substrate comprises carbon fibrils incorporated into or on said plastic.
244. The multi-well plate of any one of claims 22, 23, 25, 26, 30, 53, 57, 58, 64, or 65, wherein said substrate is substantially free of silicon and silicone.
245. The multi-well plate of any one of claims 22, 23, 25, 26, 30, 53, 57, 58, 64, or 65, wherein said substrate comprises a porous material.
246. The multi-well plate of claim 245, wherein said porous material is a filter.
247. The multi-well plate of any one of claims 15 or 21, further comprising one or more working electrode electrical contacts electrically connected to said working electrodes.
248. The multi-well plate of claim 247, wherein said one or more working electrode electrical contacts are connected to said working electrodes via conductive through-holes.
249. The multi-well plate of claim 248, wherein said conductive through-holes are filled with a conductive material.
250. The multi-well plate of claim 248, wherein said conductive through-holes are positioned between or adjacent said wells.
251. The multi-well plate of claim 247, wherein said working electrode electrical contacts are formed by screen printing a conductive material onto a surface of said substrate.
252. The multi-well plate of any one of claims 3-10, 18, 30, or 51, further comprising one or more counter electrode contacts electrically connected to said one or more counter electrode surfaces.
253. The multi-well plate of claim 252, wherein said counter electrode electrical contacts are connected to said one or more counter electrodes via substrate through-holes.
254. The multi-well plate of claim 253, wherein said conductive substrate through-holes are filled with a conductive material.
255. The multi-well plate of claim 252, wherein said counter electrode contacts are formed by screen-printing a conductive material onto a surface of said plate.
256. The multi-well plate of any one of claims 1-40 or 46-63, wherein said wells comprise an inner bottom surface and said inner surface is oxidized to expose a conductive surface.
257. The multi-well plate of any one of claims 1-40 or 46-63, wherein said wells comprise an inner bottom surface and said imzer bottom surface is oxidized to produce functionality for coupling with an assay component.
258. The multi-well plate of any one of claims 1-40 or 46-63, wherein said wells are treated with a bifunctional reagent for coupling.
259. The multi-well plate of any one of claims 1-40 or 46-63, wherein said wells comprise an inner surface and said inner surface is surface treated with a bifunctional reagent for coupling with an assay component.
260. The multi-well plate of any one of claims 1-40 or 46-63, further comprising a biospecific binder on an inner surface of said wells.
261. The multi-well plate of any one of claims 1-40 or 46-63, further comprising one or more assay reagents in said plurality of wells.
262. The multi-well plate of any one of claims 1-40 or 46-63, further comprising one or more immobilized reagents selected from: antibodies, fragments of antibodies, proteins, enzymes, enzyme substrates, inhibitors, cofactors, antigens, haptens, lipoproteins, liposaccharides, cells, sub-cellular components, cell receptors, viruses, nucleic acids, antigens, lipids, glycoproteins, carbohydrates, peptides, amino acids, hormones, protein-binding ligands, pharmacological agents, luminescent labels or combinations thereof.
263. The multi-well plate of any of claim 262, wherein said immobilized reagents comprise proteins, nucleic acids, or combinations thereof.
264. The multi-well plate of any one of claims 1-40 or 46-63, wherein two or more of said wells comprise one or more assay reagents.
265. The multi-well plate of any one of claims 1-40 or 46-63, wherein two or more of said wells comprise one or more samples.
266. The multi-well plate of any one of claims 1-40 or 46-63, further comprising a luminescent label in one or more of said plurality of wells.
267. The multi-well plate of any one of claims 1-40 or 46-63, wherein said multi-well plate further includes one or more chemiluminescence wells and/or fluorescence wells.
268. The multi-well plate of any one of claims 1-40 or 46-63, wherein said multi-well plate further includes one or more chemiluminescence wells comprising a chemiluminescence reagent and/or one or more fluorescence wells comprising a fluorescence reagent.
269. The multi-well plate of any one of claims 22, 23, 51-61 or 66, wherein said plate top is a non-conductive plastic.
270. The multi-well plate of any one of claims 22, 23, 51-61 or 66, wherein said plate top is white.
271. The multi-well plate of any one of claims 22, 23, 51-61 or 66, wherein said plate top is black.
272. The multi-well plate of any one of claims 22, 23, 51-61 or 66, wherein said plate top comprises wells having opaque walls.
273. The multi-well plate of any one of claims 22, 23, 51-61 or 66, wherein said plate top comprises 6-12 wt% whitener.
274. The multi-well plate of any one of claims 1-40, 46-63 or 66, wherein said well walls comprise 6-12 wt% whitener.
275. The multi-well plate of any one of claims 22, 23, 51-61 or 66, wherein said plate top comprises 6-12 wt% whitener selected from the group consisting of TiO2, lead oxide, alumina and silica (SiO2).
276. The multi-well plate of any one of claims 1-40, 46-63 or 66, wherein the inner surface of said wells is substantially free of silicon and silicone.
277. The multi-well plate of any one of claims 22, 23, 51-61 or 66, wherein said plate top is substantially free of silicon and silicone.
278. The multi-well plate of any one of claims 1-40, 46-63 or 66, further comprising an identification marking.
279. The multi-well plate of any one of claims 1-40, 46-63 or 66, further comprising a bar code.
280. The multi-well plate of any one of claims 1-40, 46-63 or 66, further comprising a marking and/or structural component adapted for determining plate orientation.
281. The multi-well plate of any one of claims 1-40, 46-63 or 66, further comprising a lid configured to cover said wells.
282. The multi-well plate of any one of claims 1-40, 46-63 or 66, further comprising a beveled corner.
283. The multi-well plate of any one of claims 1-40, 46-63 or 66, further comprising lips for grabbing by a robotic handler.
284. The multi-well plate of any one of claims 1-40, 46-63 or 66, further comprising legs or a shirt adapted to elevate said plate.
285. The multi-well plate of any one of claims 1 or 66, further comprising a conductive coating on said plate bottom.
286. The multi-well plate of any one of claims 22, 23, 25 or 26, further comprising a stiffening support on the plate to reduce flexing or bending of the substrate.
287. The multi-well plate of any one of claims 1-40, 46-63 or 66, further comprising a stiffening support to reduce flexing or bending of the multi-well plate.
288. The multi-well plate of claim 286, wherein said stiffening support comprises a non-conductive material and is attached to said substrate and comprises one or more openings allowing for electrical contact with said substrate.
289. The multi-well plate of claim 287, wherein said stiffening support comprises a non-conductive material and is attached to the multi-well plate and comprises one or more openings allowing for electrical contact with said multi-well plate bottom.
290. The multi-well plate of claims 52, 53, 54, or 55, wherein said plate top comprises a conductive metal coating formed thereon forming said electrically conductive surface.
291. The multi-well plate of claim 290, wherein said conductive metal coating is painted on said plate top.
292. The multi-well plate of claim 290, wherein said conductive metal coating is evaporated on said plate top.
293. The multi-well plate of claim 290, wherein said conductive metal coating is electroplated on said plate top.
294. The multi-well plate of claim 290, wherein said conductive metal coating comprises silver, Ag/Cl, nickel, copper, aluminum or combinations thereof.
295. The multi-well plate of claim 290, wherein said conductive metal coating is silver paint.
296. The multi-well plate of any one of claims 52-61, wherein said insulating layer comprises an adhesive dielectric film or an adhesive screen-printed dielectric.
297. The multi-well plate of any one of claims 52-61, wherein said insulating layer is substantially free of silicon or silicone.
298. The multi-well plate of any one of claims 52-61, wherein said insulating layer defines a plurality of fluid containment regions within each well for confining fluids on the bottom of said wells.
299. The multi-well plate of claim 298, wherein containment surfaces defined by said plurality of fluid containment regions comprise a plurality of different reagents for conducting multiple detections and/or measurements in an individual well.
300. The multi-well plate of claim 52 or 54, wherein said electrically conductive layer comprises a composite containing carbon particles in or on a matrix.
301. The multi-well plate of claim 300, wherein said carbon particles comprises carbon nanotubes, carbon fibrils, carbon black or combinations thereof.
302. The multi-well plate of claim 52 or 54, wherein said electrically conductive layer comprises fibrils coated with a conductive material.
303. The multi-well plate of claim 52 or 54, wherein said electrically conductive layer comprises a carbon coating on a substrate.
304. A method of making the multi-well plate of claim 52 comprising:
(a) forming at least one conductive coating onto a substrate thereby forming said electrically conductive layer having one or more working electrodes;
(b) forming at least one insulating layer on said at least one conductive coating, said at least one insulating layer having a plurality of insulating layer openings; and (c) affixing a plate top having a plurality of plate top openings onto said insulating layer;
wherein said insulating layer openings and said plate top openings are aligned to form said plurality of wells.
(a) forming at least one conductive coating onto a substrate thereby forming said electrically conductive layer having one or more working electrodes;
(b) forming at least one insulating layer on said at least one conductive coating, said at least one insulating layer having a plurality of insulating layer openings; and (c) affixing a plate top having a plurality of plate top openings onto said insulating layer;
wherein said insulating layer openings and said plate top openings are aligned to form said plurality of wells.
305. The method of claim 304, wherein said at least one conductive coating further forms one or more counter electrodes.
306. The method of claim 304, wherein said plate top comprises one or more conductive surfaces forming one or more counter electrodes.
307. The method of claim 304, further comprising the step of applying one or more conductive surfaces onto said insulating layer forming one or more counter electrodes.
308. The method of claim 304, wherein said at least one conductive coating is applied by screen printing.
309. The multi-well plate of any one of claims 56 or 60, wherein said first electrical conductive layer forms one or more working electrodes.
310. The multi-well plate of any one of claims 56 or 60, wherein said first electrically conductive layer is partitioned into one or more separately addressable sectors.
311. The multi-well plate of any one of claims 56 or 59-61, wherein said first electrically conductive layer comprises a porous material.
312. The multi-well plate of any one of claims 56 or 59-61, wherein said first electrically conductive film comprises silver.
313. The multi-well plate any one of claims 56 or 59-61, wherein said first electrically conductive layer comprises a carbon coating on a substrate.
314. The multi-well plate of any one of claims 56 or 59-61, wherein said first electrically conductive layer comprises a carbon ink on a substrate.
315. The multi-well plate of any one of claims 56 or 59-61, wherein said first electrically conductive layer is formed by applying a carbon ink on a substrate.
316. The multi-well plate of any one of claims 56 or 59-61, wherein said second electrical conductive layer forms one or more counter electrodes.
317. The multi-well plate of any one of claims 56 or 59-61, wherein said second electrically conductive film comprises silver.
318. The multi-well plate of any one of claims 56 or 59-61, wherein said second electrically conductive layer comprises a carbon ink on a substrate.
319. The multi-well plate of any one of claims 52-57, wherein said insulating layer comprises an adhesive dielectric film or an adhesive screen-printed dielectric.
320. The multi-well plate of claim 59, wherein said insulating layer comprises a first half having well openings and a second half having contact holes, wherein said insulating layer folds back and around said first electrically conductive layer so as to: (i) provide a bottom contact surface to one or more counter electrodes on said first half of said insulating layer and (ii) provide said contact holes for electrical contact to said first electrically conductive layer.
321. The multi-well plate of any one of claims 52-57, wherein said insulating layer defines a plurality of fluid containment regions for confining fluids on the bottom of said wells.
322. The multi-well plate of claim 321, wherein containment surfaces defined by said plurality of fluid containment regions comprise a plurality of different reagents for conducting multiple detections and/or measurements in an individual well.
323. A method of making the multi-well plate of claim 59, comprising:
(a) forming said insulating layer having insulating layer openings onto said first electrically conductive layer; and (b) applying a conductive film having conductive film openings onto said insulating layer forming said second electrically conductive layer, wherein said insulating layer openings and said conductive film openings are aligned.
(a) forming said insulating layer having insulating layer openings onto said first electrically conductive layer; and (b) applying a conductive film having conductive film openings onto said insulating layer forming said second electrically conductive layer, wherein said insulating layer openings and said conductive film openings are aligned.
324. The method of claim 323, further comprising applying a top plate having top plate openings onto said second electrically conductive layer such that said top plate openings, said insulating film openings and said conductive film openings are aligned.
325. A method of making the multi-well plate of claim 1, comprising:
(a) forming said patterned electrodes and two or more working electrode contacts connected to said patterned electrodes on said bottom plate, thereby forming said independently addressable sectors of jointly addressable electrodes; and (b) attaching a top plate having a plurality of openings onto said bottom plates;
wherein said plurality of openings forms a plurality of wells, each having at least one working electrode.
(a) forming said patterned electrodes and two or more working electrode contacts connected to said patterned electrodes on said bottom plate, thereby forming said independently addressable sectors of jointly addressable electrodes; and (b) attaching a top plate having a plurality of openings onto said bottom plates;
wherein said plurality of openings forms a plurality of wells, each having at least one working electrode.
326. A method of making the multi-well plate of claim 56, comprising folding a layer comprising a counter electrode film and having openings around a conductive substrate.
327. The method of claim 326, wherein said conductive substrate is sectioned into one or more separately addressable sectors.
328. The multi-well plate of claim 1, wherein said electrodes comprise metal-coated pressure sensitive adhesive.
329. The multi-well plate of claim 1, wherein said electrodes comprise evaporated metal.
330. The multi-well plate of claim 2, 11, or 17, wherein said first electrode surface and/or said second electrode surface comprise metal-coated pressure sensitive adhesive.
331. The multi-well plate of claim 2, 11 or 17, wherein said first electrode surface and/or said second electrode surface comprise evaporated metal.
332. The system of claim 93, 94 or 95, wherein said multi-well plate further comprises an assay buffer.
333. The system of claim 93, 94 or 95, wherein said multi-well plate further comprises one or more assay samples.
334. The system of claim 93, 94 or 95, wherein said multi-well plate further comprises an assay buffer.
335. An apparatus for measuring luminescence from a multi-well assay plate having a plurality of wells, said apparatus comprising:
(a) a light detector for measuring said luminescence within a portion of said plurality of wells; and (b) electrical connections adapted to connect a source of electrical energy to said wells.
(a) a light detector for measuring said luminescence within a portion of said plurality of wells; and (b) electrical connections adapted to connect a source of electrical energy to said wells.
336. An apparatus for measuring luminescence from a multi-well assay plate having a plurality of independently addressable sectors of jointly addressable wells, said apparatus comprising:
(a) a source of electrical energy; and (b) one or more electrical corrections adapted to independently address said independently addressable sectors.
(a) a source of electrical energy; and (b) one or more electrical corrections adapted to independently address said independently addressable sectors.
337. An apparatus for measuring luminescence from a multi-well assay plate having a plurality of independently addressable sectors of jointly addressable wells, said apparatus comprising:
(a) a support adapted to hold said multi-well assay plate;
(b) a source of electrical energy; and (c) one or more electrical connections adapted to connect said source of electrical energy to said independently addressable sectors;
wherein said electrical connections and said support are adapted to move relative to one another to allow for sequentially contacting said sectors.
(a) a support adapted to hold said multi-well assay plate;
(b) a source of electrical energy; and (c) one or more electrical connections adapted to connect said source of electrical energy to said independently addressable sectors;
wherein said electrical connections and said support are adapted to move relative to one another to allow for sequentially contacting said sectors.
338. An apparatus for measuring luminescence from a multi-well assay plate having a plurality of independently addressable sectors of jointly addressable wells, said apparatus comprising:
(a) a light detector adapted to measure luminescence from said wells;
(b) a support adapted to hold said multi-well assay plate;
(c) a source of electrical energy; and (d) one or more electrical connections adapted to connect said source of electrical energy to said independently addressable sectors;
wherein said light detector and said support are adapted to move relative to one another to allow for sequentially measuring luminescence from said sectors.
(a) a light detector adapted to measure luminescence from said wells;
(b) a support adapted to hold said multi-well assay plate;
(c) a source of electrical energy; and (d) one or more electrical connections adapted to connect said source of electrical energy to said independently addressable sectors;
wherein said light detector and said support are adapted to move relative to one another to allow for sequentially measuring luminescence from said sectors.
339. An apparatus for measuring luminescence from a mufti-well assay plate having a plurality of wells, said apparatus comprising a light detector adapted to measure luminescence emitted from said plurality of wells and a plate holder adapted to hold said plate onto a measuring platform during said measuring.
340. An apparatus for measuring luminescence from a multi-well plate having a plurality of wells comprising an imaging system, said imaging system adapted to simultaneously image emitted luminescence from at least two of said plurality of wells, wherein said imaging collects a cone of luminescence having a cone full angle of at least 10 degrees.
341. An apparatus for measuring luminescence from a multi-well assay plate having a plurality of wells comprising:
(a) an imaging system, said imaging system adapted to image at least a portion of said plurality of wells; and (b) a support adapted to hold said multi-well assay plate in a measurement position where said camera can image said portion;
wherein said imaging system and/or said support are adapted to image said plurality of wells in sectors and thereby measure said luminescence.
(a) an imaging system, said imaging system adapted to image at least a portion of said plurality of wells; and (b) a support adapted to hold said multi-well assay plate in a measurement position where said camera can image said portion;
wherein said imaging system and/or said support are adapted to image said plurality of wells in sectors and thereby measure said luminescence.
342. An apparatus for measuring luminescence from a multi-well assay plate having a plurality of wells comprising:
(a) an imaging system, said imaging system adapted to image at least a portion of said plurality of wells and thereby measure said luminescence; and (b) a source of electrical energy adapted to provide electrical energy to said plurality of wells in sectors.
(a) an imaging system, said imaging system adapted to image at least a portion of said plurality of wells and thereby measure said luminescence; and (b) a source of electrical energy adapted to provide electrical energy to said plurality of wells in sectors.
343. An apparatus for measuring luminescence from a multi-well assay plate having a plurality of wells comprising:
(a) an imaging system, said imaging system adapted to image said plurality of wells in sectors and thereby measure said luminescence in sectors;
and (b) a source of electrical energy, said electrical energy applied as an electrical voltage or current to said portion of said plurality of wells.
(a) an imaging system, said imaging system adapted to image said plurality of wells in sectors and thereby measure said luminescence in sectors;
and (b) a source of electrical energy, said electrical energy applied as an electrical voltage or current to said portion of said plurality of wells.
344. An apparatus for measuring luminescence from a multi-well assay plate having a plurality of wells comprising:
(a) an imaging system, said imaging system adapted to image said multi-well assay plate;
(b) a support adapted to hold said multi-well assay plate in a measurement position;
(c) a source of electrical energy; and (d) electrical connections adapted to connect said multi-well assay plate to said source.
(a) an imaging system, said imaging system adapted to image said multi-well assay plate;
(b) a support adapted to hold said multi-well assay plate in a measurement position;
(c) a source of electrical energy; and (d) electrical connections adapted to connect said multi-well assay plate to said source.
345. The apparatus of claim 344, wherein said plurality of wells comprise a plurality of independently addressable sectors and said electrical connections are adapted to connect said sectors of said multi-well plate to said source.
346. An apparatus for measuring luminescence from a multi-well assay plate having a plurality of independently addressable sectors comprising jointly addressable wells comprising:
(a) an imaging system adapted to image a sector of said multi-well assay plate;
(b) a support adapted to hold said multi-well assay plate in a measurement position;
(c) a source of electrical energy; and (d) electrical connections adapted to connect said sector of said multi-well plate to said source;
wherein said apparatus is adapted to connect said electrical connections to said plurality of sectors and/or image said plurality of sectors sequentially.
(a) an imaging system adapted to image a sector of said multi-well assay plate;
(b) a support adapted to hold said multi-well assay plate in a measurement position;
(c) a source of electrical energy; and (d) electrical connections adapted to connect said sector of said multi-well plate to said source;
wherein said apparatus is adapted to connect said electrical connections to said plurality of sectors and/or image said plurality of sectors sequentially.
347. An apparatus for measuring luminescence from a multi-well assay plate, said multi-well plate comprising a substrate having a top surface and a bottom surface, said multi-well plate having an array of wells corresponding to a standard 96-well plate configuration, said array comprising one or more of the following:
a first sector having wells A1 through A4, B1 through B4, C1 through C4, and D1 through D4;
a second sector having wells A5 through A8, B5 through B8, C5 through C8, and D5 through D8;
a third sector having wells A9 through A12, B9 through B12, C9 through C12, and D9 through D12;
a fourth sector having wells E1 through E4, F1 through F4, G1 through G4, and H1 through H4;
a fifth sector having wells E5 through E8, F5 through F8, G5 through G8, and H5 through H8; and a sixth sector having wells E9 through E12, F9 through F12, G9 through G12, and H9 through H12;
said apparatus comprising a light detector adapted to measure luminescence emitted from said wells and a plurality of electrical connections, wherein said plurality of electrical connections are configured to contact said bottom surface.
a first sector having wells A1 through A4, B1 through B4, C1 through C4, and D1 through D4;
a second sector having wells A5 through A8, B5 through B8, C5 through C8, and D5 through D8;
a third sector having wells A9 through A12, B9 through B12, C9 through C12, and D9 through D12;
a fourth sector having wells E1 through E4, F1 through F4, G1 through G4, and H1 through H4;
a fifth sector having wells E5 through E8, F5 through F8, G5 through G8, and H5 through H8; and a sixth sector having wells E9 through E12, F9 through F12, G9 through G12, and H9 through H12;
said apparatus comprising a light detector adapted to measure luminescence emitted from said wells and a plurality of electrical connections, wherein said plurality of electrical connections are configured to contact said bottom surface.
348. The apparatus of claim 347, wherein said plurality of electrical connections are configured to contact said bottom surface between said wells.
349. The apparatus of claim 347, wherein each sector comprises one or more electrical contacts at one or more of the following locations:
(i) two or more of first sector locations: A1-B2; A2-B3; A3-B4;
C1-D2; C2-D3; C3-D4;
(ii) two or more of second sector locations: A5-B6; A6-B7; A7-B8; C5-D6; C6-D7; C7-D8;
(iii) two or more of third sector locations: A9-B10; A10-B11; A11-B12; C9-D10; C10-D11; C11-D12;
(iv) two or more of fourth sector locations: E1-F2; E2-F3; E3-F4;
G1-H2; G2-H3; G3-H4;
(v) two or more of fifth sector locations: E5-F6; E6-F7; E7-F8; G5-H6; G6-H7; G7-H8; and (vi) two or more of sixth sector locations: E9-F10; E10-F11; E11-F12; G9-H10; G10-H11; G11-H12.
(i) two or more of first sector locations: A1-B2; A2-B3; A3-B4;
C1-D2; C2-D3; C3-D4;
(ii) two or more of second sector locations: A5-B6; A6-B7; A7-B8; C5-D6; C6-D7; C7-D8;
(iii) two or more of third sector locations: A9-B10; A10-B11; A11-B12; C9-D10; C10-D11; C11-D12;
(iv) two or more of fourth sector locations: E1-F2; E2-F3; E3-F4;
G1-H2; G2-H3; G3-H4;
(v) two or more of fifth sector locations: E5-F6; E6-F7; E7-F8; G5-H6; G6-H7; G7-H8; and (vi) two or more of sixth sector locations: E9-F10; E10-F11; E11-F12; G9-H10; G10-H11; G11-H12.
350. An apparatus for measuring luminescence from a mufti-well plate, said multi-well plate comprising a substrate having a top surface and a bottom surface, said multi-well plate having an array of wells corresponding to a standard 384-well plate configuration, said array comprising rows A through P and columns 1 through 24, said array comprising one or more of the following:
a first sector having wells Al through A8, B1 through B8, C1 through C8, D1 through D8, E1 through E8, F1 through F8, G1 through G8, and H1 through H8;
a second sector having wells A9 through A16, B9 through B16, C9 through C16, D9 through D16, E9 through E16, F9 through F16, G9 through G16, and H9 through H16;
a third sector having wells A17 through A24, B17 through B24, C17 through C24, D17 through D24, E17 through E24, F17 through F24, G17 through G24, and H17 through H24;
a fourth sector having wells I1 through I8, J1 through J8, K1 through K8, L1 through L8, M1 through M8, N1 through N8, O1 through O8 and P1 through P8;
a fifth sector having wellsI9 through I16, J9 through J16, K9 through K16, L9 through L16, M9 through M16, N9 through N16, O9 through O16 and P9 through P16; and a sixth sector having wellsI17 through I24, J17 through J24, K17 through K24, L17 through L24, M17 through M24, N17 through N24, O17 through O24 and P17 through P24;
said apparatus comprising a light detector adapted to measure luminescence emitted from said plurality of wells and a plurality of electrical connections, wherein said plurality of electrical connections are configured to contact said bottom surface.
a first sector having wells Al through A8, B1 through B8, C1 through C8, D1 through D8, E1 through E8, F1 through F8, G1 through G8, and H1 through H8;
a second sector having wells A9 through A16, B9 through B16, C9 through C16, D9 through D16, E9 through E16, F9 through F16, G9 through G16, and H9 through H16;
a third sector having wells A17 through A24, B17 through B24, C17 through C24, D17 through D24, E17 through E24, F17 through F24, G17 through G24, and H17 through H24;
a fourth sector having wells I1 through I8, J1 through J8, K1 through K8, L1 through L8, M1 through M8, N1 through N8, O1 through O8 and P1 through P8;
a fifth sector having wellsI9 through I16, J9 through J16, K9 through K16, L9 through L16, M9 through M16, N9 through N16, O9 through O16 and P9 through P16; and a sixth sector having wellsI17 through I24, J17 through J24, K17 through K24, L17 through L24, M17 through M24, N17 through N24, O17 through O24 and P17 through P24;
said apparatus comprising a light detector adapted to measure luminescence emitted from said plurality of wells and a plurality of electrical connections, wherein said plurality of electrical connections are configured to contact said bottom surface.
351. The apparatus of claim 350, wherein each sector comprises one or more electrical contacts at one or more of the following locations:
(i) two or more first sector locations: B2-C3; B4-C5; B6-C7; F2-G3; F4 -G5; F6-G7;
(ii) two or more second sector locations: B10-C11; B12-C13; B14-C15; F10-G11; F12-G13; F14 -G15;
(iii) two or more third sector locations: B18-C19; B20-C21; B22-C23; F18-G19; F20-G21; F22-G23;
(iv) two or more fourth sector locations: J2-K3; J4-K5; J6-K7; N2-O3; N4-O5; N6-O7;
(v) two or more fifth sector locations: J10-K11; J12-K13; J14-K15;
N10-O11; N12-O13; N14-O15; and (vi) two or more sixth sector locations: J18-K19; J20-K21; J22-K23; N18-019; N20-021; N22-023.
(i) two or more first sector locations: B2-C3; B4-C5; B6-C7; F2-G3; F4 -G5; F6-G7;
(ii) two or more second sector locations: B10-C11; B12-C13; B14-C15; F10-G11; F12-G13; F14 -G15;
(iii) two or more third sector locations: B18-C19; B20-C21; B22-C23; F18-G19; F20-G21; F22-G23;
(iv) two or more fourth sector locations: J2-K3; J4-K5; J6-K7; N2-O3; N4-O5; N6-O7;
(v) two or more fifth sector locations: J10-K11; J12-K13; J14-K15;
N10-O11; N12-O13; N14-O15; and (vi) two or more sixth sector locations: J18-K19; J20-K21; J22-K23; N18-019; N20-021; N22-023.
352. An apparatus for measuring luminescence from a multi-well plate, said multi-well plate having to a standard well plate configuration and further having an 2×3 array of square sectors, said apparatus comprising a light detector adapted to measure luminescence emitted from said plurality of wells and a plurality of electrical connections, wherein said plurality of electrical connections are configured to contact the bottom surface of said plate between said wells.
353. The apparatus of claim 352, wherein each sector comprises one or more electrical contacts located at one or more of the following locations (X, Y) measured (inches) from the top left corner of said plate (right side up):
(i) two or more of first sector locations (inches, ~ 0.125"): (0.743, 0.620), (1.097, 0.620), (1.451, 0.620), (0.743, 1.329), (1.097, 1.329), (1.451, 1.329);
(ii) two or more of second sector locations (inches, ~ 0.125"):
(2.161, 0.620), (2.515, 0.620), (2.869, 0.620), (2.161, 1.329), (2.515, 1.329), (2.869, 1.329);
(iii) two or more of third sector locations (inches, ~ 0.125"): (3.579, 0.620), (3.933, 0.620), (4.287, 0.620), (3.579, 1.329), (3.933, 1.329), (4.287, 1.329);
(iv) two or more of fourth sector locations (inches, ~ 0.125"):
(0.743, 2.038), (1.097, 2.038), (1.451, 2.038), (0.743, 2.747), (1.097, 2.747), (1.451, 2.747);
(v) two or more of fifth sector locations (inches, ~ 0.125"): (2.161, 2.038), (2.515, 2.038), (2.869, 2.038), (2.161, 2.747), (2.515, 2.747), (2.869, 2.747); and (vi) two or more of sixth sector locations (inches, ~ 0.125"): (3.579, 2.038), (3.933, 2.038), (4.287, 2.038), (3.579, 2.747), (3.933, 2.747), (4.287, 2.747).
(i) two or more of first sector locations (inches, ~ 0.125"): (0.743, 0.620), (1.097, 0.620), (1.451, 0.620), (0.743, 1.329), (1.097, 1.329), (1.451, 1.329);
(ii) two or more of second sector locations (inches, ~ 0.125"):
(2.161, 0.620), (2.515, 0.620), (2.869, 0.620), (2.161, 1.329), (2.515, 1.329), (2.869, 1.329);
(iii) two or more of third sector locations (inches, ~ 0.125"): (3.579, 0.620), (3.933, 0.620), (4.287, 0.620), (3.579, 1.329), (3.933, 1.329), (4.287, 1.329);
(iv) two or more of fourth sector locations (inches, ~ 0.125"):
(0.743, 2.038), (1.097, 2.038), (1.451, 2.038), (0.743, 2.747), (1.097, 2.747), (1.451, 2.747);
(v) two or more of fifth sector locations (inches, ~ 0.125"): (2.161, 2.038), (2.515, 2.038), (2.869, 2.038), (2.161, 2.747), (2.515, 2.747), (2.869, 2.747); and (vi) two or more of sixth sector locations (inches, ~ 0.125"): (3.579, 2.038), (3.933, 2.038), (4.287, 2.038), (3.579, 2.747), (3.933, 2.747), (4.287, 2.747).
354. An apparatus for measuring luminescence from a multi-well assay plate having a plurality of wells comprising: an array of light detectors adapted to measure light from at least a portion of said multi-well assay plate; and (a) a source of electrical energy for providing electrical energy to said multi-well plate.
355. An apparatus for measuring luminescence from a multi-well assay plate having a plurality of independently addressable sectors of jointly addressable wells comprising:
(a) an array of photodiodes adapted to measure light from said plurality of independently addressable sectors; and (b) a source of electrical energy for providing electrical energy to said multi-well plate, wherein said array of photodiodes is configured to align with each independently addressable sector such that each photodiode corresponds with one well within said sector whereby luminescence from each well is measured by one corresponding photodiode.
(a) an array of photodiodes adapted to measure light from said plurality of independently addressable sectors; and (b) a source of electrical energy for providing electrical energy to said multi-well plate, wherein said array of photodiodes is configured to align with each independently addressable sector such that each photodiode corresponds with one well within said sector whereby luminescence from each well is measured by one corresponding photodiode.
356. An apparatus for measuring luminescence from a multi-well assay plate having a plurality of independently addressable sectors of jointly addressable wells comprising:
(a) an array of photodiodes adapted to measure light from said plurality of independently addressable sectors; and (b) a source of electrical energy for providing electrical energy to said multi-well plate;
wherein said array of photodiodes is configured to align with each independently addressable sector such that each well within said sector has one or more photodiodes aligned therewith to measure emitted luminescence.
(a) an array of photodiodes adapted to measure light from said plurality of independently addressable sectors; and (b) a source of electrical energy for providing electrical energy to said multi-well plate;
wherein said array of photodiodes is configured to align with each independently addressable sector such that each well within said sector has one or more photodiodes aligned therewith to measure emitted luminescence.
357. The apparatus of claim 356, wherein said one or more photodiodes measure less then 5% cross-talk luminescence from non-aligned wells.
358. An apparatus for measuring luminescence from a multi-well assay plate having a plurality of independently addressable sectors of jointly addressable wells comprising:
(a) an array of light detectors adapted to measure light from at least a portion of said multi-well assay plate; and (b) a source of electrical energy for providing electrical energy to said multi-well plate;
wherein said apparatus measures said luminescence in sectors.
(a) an array of light detectors adapted to measure light from at least a portion of said multi-well assay plate; and (b) a source of electrical energy for providing electrical energy to said multi-well plate;
wherein said apparatus measures said luminescence in sectors.
359. An apparatus for measuring luminescence from a multi-well assay plate having a plurality of independently addressable sectors of jointly addressable wells comprising:
(a) an array of light detectors adapted to measure light from at least a portion of said multi-well assay plate; and (b) a source of electrical energy for providing electrical energy to said multi-well plate;
wherein said apparatus induces luminescence in said wells in sectors.
(a) an array of light detectors adapted to measure light from at least a portion of said multi-well assay plate; and (b) a source of electrical energy for providing electrical energy to said multi-well plate;
wherein said apparatus induces luminescence in said wells in sectors.
360. An apparatus for measuring luminescence from a multi-well assay plate having a plurality of independently addressable sectors of jointly addressable wells comprising:
(a) an array of light detectors adapted to measure light from said multi-well assay plate in sectors; and (b) a support for said multi-well plate;
wherein said apparatus is adapted to allow said array of light detectors to move relative said support so as to allow for alignment of each sector with said array of detectors.
(a) an array of light detectors adapted to measure light from said multi-well assay plate in sectors; and (b) a support for said multi-well plate;
wherein said apparatus is adapted to allow said array of light detectors to move relative said support so as to allow for alignment of each sector with said array of detectors.
361. A method for measuring luminescence from a multi-well assay plate having a plurality of wells, wherein electrical energy is provided to said plurality of wells in sectors.
362. A method for measuring luminescence from a multi-well assay plate having a plurality of wells, wherein said luminescence is measured in sectors.
363. A method for measuring luminescence from a multi-well assay plate having a plurality of independently addressable sectors of jointly addressable wells, said method comprising:
(a) providing electrical energy to said multi-well assay plate in sectors; and (b) measuring luminescence from said multi-well assay plate.
(a) providing electrical energy to said multi-well assay plate in sectors; and (b) measuring luminescence from said multi-well assay plate.
364. A method for measuring luminescence from a multi-well assay plate having a plurality of wells comprising:
(a) providing electrical energy to a first sector of said plurality of wells;
(b) measuring luminescence from said first sector of said plurality of wells;
(c) providing electrical energy to a second sector of said plurality of wells;
and (d) measuring luminescence from said second sector of said plurality of wells.
(a) providing electrical energy to a first sector of said plurality of wells;
(b) measuring luminescence from said first sector of said plurality of wells;
(c) providing electrical energy to a second sector of said plurality of wells;
and (d) measuring luminescence from said second sector of said plurality of wells.
365. A method for measuring luminescence from a multi-well assay plate having a plurality of wells comprising:
(a) measuring luminescence from a first sector of said plurality of wells;
and (b) measuring luminescence from a second sector of said plurality of wells.
(a) measuring luminescence from a first sector of said plurality of wells;
and (b) measuring luminescence from a second sector of said plurality of wells.
366. A method of conducting one or more assays using an apparatus for measuring luminescence from a multi-well assay plate, said multi-well plate comprising a substrate having a top surface and a bottom surface and an array of wells and said apparatus comprising a light detector adapted to measure luminescence emitted from said array of wells, wherein said method comprises contacting said plate bottom with a plurality of electrical connections and measuring luminescence, wherein said plurality of electrical connections contact said bottom surface.
367. The method of claim 366, wherein said bottom surface is contacted between said wells.
368. A method for measuring luminescence from a multi-well plate having a plurality of wells comprising simultaneously imaging emitted luminescence from at least two of said plurality of wells, wherein said imaging collects a cone of luminescence having a cone full angle of at least 10 degrees.
369. A method for measuring luminescence from a multi-well assay plate having a plurality of wells comprising:
(a) forming a first image of a first sector of said multi-well assay plate with a camera; and (b) forming a second image of a second sector of said multi-well assay plate.
(a) forming a first image of a first sector of said multi-well assay plate with a camera; and (b) forming a second image of a second sector of said multi-well assay plate.
370. A method for measuring luminescence from a multi-well assay plate having a plurality of wells comprising:
(a) aligning a first sector of said multi-well assay plate with a camera;
(b) measuring luminescence from said first sector of said multi-well assay plate with said camera;
(c) aligning a second sector of said multi-well assay plate with said camera;
and (d) measuring luminescence from said second sector of said multi-well assay plate with said camera.
(a) aligning a first sector of said multi-well assay plate with a camera;
(b) measuring luminescence from said first sector of said multi-well assay plate with said camera;
(c) aligning a second sector of said multi-well assay plate with said camera;
and (d) measuring luminescence from said second sector of said multi-well assay plate with said camera.
371. A method for measuring luminescence from a multi-well assay plate having a plurality of wells comprising:
(a) providing electrical energy to a first sector of said plurality of wells;
(b) measuring luminescence from said first sector of said plurality of wells using a camera;
(c) providing electrical energy to a second sector of said plurality of wells;
and (d) measuring luminescence from said second sector of said plurality of wells using said camera.
(a) providing electrical energy to a first sector of said plurality of wells;
(b) measuring luminescence from said first sector of said plurality of wells using a camera;
(c) providing electrical energy to a second sector of said plurality of wells;
and (d) measuring luminescence from said second sector of said plurality of wells using said camera.
372. A method of conducting one or more assays using an apparatus for measuring luminescence from a multi-well plate, said multi-well plate comprising a substrate having a top surface and a bottom surface, said multi-well plate having an array of wells corresponding to a standard 96-well plate configuration, said array comprising one or more of the following:
a first sector having wells A1 through A4, B1 through B4, C1 through C4, and D1 through D4;
a second sector having wells A5 through A8, B5 through B8, C5 through C8, and D5 through D8;
a third sector having wells A9 through A12, B9 through B12, C9 through C12, and D9 through D12;
a fourth sector having wells E1 through E4, F1 through F4, G1 through G4, and H1 through H4;
a fifth sector having wells E5 through E8, F5 through F8, G5 through G8, and H5 through H8; and a sixth sector having wells E9 through E12, F9 through F12, G9 through G12, and H9 through H12;
said apparatus comprising a light detector adapted to measure luminescence emitted from said plurality of wells, wherein said method comprises:
(a) contacting each sector of said bottom surface with a plurality of electrical connections at one or more sector contact locations, wherein said plurality of electrical connections contact said bottom surface; and (b) measuring emitted luminescence.
a first sector having wells A1 through A4, B1 through B4, C1 through C4, and D1 through D4;
a second sector having wells A5 through A8, B5 through B8, C5 through C8, and D5 through D8;
a third sector having wells A9 through A12, B9 through B12, C9 through C12, and D9 through D12;
a fourth sector having wells E1 through E4, F1 through F4, G1 through G4, and H1 through H4;
a fifth sector having wells E5 through E8, F5 through F8, G5 through G8, and H5 through H8; and a sixth sector having wells E9 through E12, F9 through F12, G9 through G12, and H9 through H12;
said apparatus comprising a light detector adapted to measure luminescence emitted from said plurality of wells, wherein said method comprises:
(a) contacting each sector of said bottom surface with a plurality of electrical connections at one or more sector contact locations, wherein said plurality of electrical connections contact said bottom surface; and (b) measuring emitted luminescence.
373. A method of conducting one or more assays using an apparatus for measuring luminescence from a multi-well assay plate having 96 wells, said apparatus comprising a source of electrical energy for generating electrode induced luminescence within said plurality of wells and a camera for measuring luminescence emitted from said plurality of wells, wherein said method comprises introducing approximately 50 to 150 microliters of assay mixture into two or more of said plurality of wells and measuring said assay mixture from said wells.
374. A method of conducting one or more assays using an apparatus for measuring luminescence from a multi-well assay plate having 384 wells, said apparatus comprising a source of electrical energy for generating electrode induced luminescence within said plurality of wells and a camera for measuring luminescence emitted from said plurality of wells, wherein said method comprises introducing 20-60 microliters of assay mixture into two or more of said plurality of wells and measuring said assay mixture from said wells.
375. A method for measuring luminescence from a multi-well assay plate having a plurality of wells comprising:
(a) providing electrical energy to a first sector of said plurality of wells;
(b) measuring luminescence from said first sector of said plurality of wells with an array of light detectors;
(c) providing electrical energy to a second sector of said plurality of wells;
and (d) measuring luminescence from said second sector with said array of light detectors.
(a) providing electrical energy to a first sector of said plurality of wells;
(b) measuring luminescence from said first sector of said plurality of wells with an array of light detectors;
(c) providing electrical energy to a second sector of said plurality of wells;
and (d) measuring luminescence from said second sector with said array of light detectors.
376. A method for measuring luminescence from a multi-well assay plate having a plurality of wells comprising:
(a) providing electrical energy to a first sector of said plurality of wells;
(b) measuring luminescence from said first sector of said plurality of wells using an array of light detectors;
(c) providing electrical energy to a second sector of said plurality of wells;
and (d) measuring luminescence from said second sector of said plurality of wells using said array of light detectors.
(a) providing electrical energy to a first sector of said plurality of wells;
(b) measuring luminescence from said first sector of said plurality of wells using an array of light detectors;
(c) providing electrical energy to a second sector of said plurality of wells;
and (d) measuring luminescence from said second sector of said plurality of wells using said array of light detectors.
377. A method for measuring luminescence from a multi-well assay plate having a plurality of wells comprising:
(a) providing electrical energy to a first sector of said multi-well assay plate;
(b) measuring luminescence from said first sector of said multi-well assay plate with an array of light detectors;
(c) aligning a second sector of said multi-well assay plate with said array of light detectors; and (d) measuring luminescence from said second sector of said multi-well assay plate with said array of light detectors.
(a) providing electrical energy to a first sector of said multi-well assay plate;
(b) measuring luminescence from said first sector of said multi-well assay plate with an array of light detectors;
(c) aligning a second sector of said multi-well assay plate with said array of light detectors; and (d) measuring luminescence from said second sector of said multi-well assay plate with said array of light detectors.
378. A method for measuring luminescence from a multi-well assay plate having a plurality of wells comprising:
(a) providing electrical energy to a first sector of said multi-well assay plate;
(b) measuring luminescence from said first sector of said multi-well assay plate with an array of light detectors;
(c) aligning a second sector of said multi-well assay plate with said array of light detectors; and (d) measuring luminescence from said second sector of said multi-well assay plate with said array of light detectors.
(a) providing electrical energy to a first sector of said multi-well assay plate;
(b) measuring luminescence from said first sector of said multi-well assay plate with an array of light detectors;
(c) aligning a second sector of said multi-well assay plate with said array of light detectors; and (d) measuring luminescence from said second sector of said multi-well assay plate with said array of light detectors.
379. A method of conducting one or more assays using an apparatus for measuring luminescence from a multi-well assay plate having a plurality of wells arranged in an array, said method comprising inducing and measuring said luminescence from said plurality of wells row by row or column by column.
380. A system for conducting an electrode induced luminescence assay comprising an apparatus for inducing and measuring luminescence, a multi-well plate and an electrochemiluminescence reagent.
381. A system for conducting an electrode induced luminescence assay comprising an apparatus for inducing and measuring electrode induced luminescence and a multi-well plate.
382. A system for conducting an electrode induced luminescence assay comprising the apparatus of any one of claims 335-360 and further comprising a multi-well assay plate.
383. The apparatus of any one of claims 341-342, wherein said portion comprises two or more wells.
384. The apparatus of any one of claims 336-338, 341-343, 345-351, 353 or 355-360, wherein said sectors include more than one well and less than 50% of said plurality of wells.
385. The apparatus of any one of claims 336-338, 341-343, 345-351, 353 or 355-360, wherein said sectors include more than one well and less than 40% of said plurality of wells.
386. The apparatus of any one of claims 336-338, 341-343, 345-351, 353 or 355-360, wherein said sectors include more than one well and less than 30% of said plurality of wells.
387. The apparatus of any one of claims 336-338, 341-343, 345-351, 353 or 355-360, wherein said sectors include more than one well and less than 20% of said plurality of wells.
388. The apparatus of any one of claims 336-338, 341-343, 345-351, 353 or 355-360, wherein said sectors include more than one well and less than 10% of said plurality of wells.
389. The apparatus of any one of claims 336-338, 341-343, 345-351, 353 or 355-360, wherein said sectors include more than one well and less than 5% of said plurality of wells.
390. The apparatus of any one of claims 336-338, 341-343, 345-349 or 355-360, wherein said sectors comprise a 4 × 4 array of said wells.
391. The apparatus of any one of claims 336-338, 341-343, 345-351 or 355-360, wherein said multi-well plate comprises a 2×3 array of sectors.
392. The apparatus of any one of claims 336-338, 341-343, 345-346 or 355-360, wherein said sector comprises one or more rows or one or more columns of said wells.
393. The apparatus of any one of claims 335-346 or 355-360, wherein said multi-well plate comprises an array of overlapping sectors, each sector comprising alternating members of a row and/or a column of said plurality of wells.
394. The apparatus of any one of claims 335-346 or 355-360, wherein said multi-well plate comprises segmented rows and/or segmented columns, said segmented rows or segmented columns comprising alternating wells and at least two sectors are overlapping on said multi-well plate.
395. The apparatus of any one of claims 336 or 337, further comprising a light detector positioned to measure luminescence from said plurality of wells.
396. The apparatus of any one of claims 336 or 337, further comprising a light detector positioned to measure luminescence from said sector.
397. The apparatus of any one of claims 335-360, wherein said apparatus is configured so a single bright well will rise the mean measured luminescence values of neighboring wells by no more than 0.0001 times the value of the bright well.
398. The apparatus of any of claims 354-360, wherein said apparatus is configured so that no more than 5 parts in 1000 luminescence emissions from any well of a 96 well plate shall appear in the measured luminescence of adjacent wells.
399. The apparatus of any one of claims 335-360, further comprising a light filter adapted to select a specified emission of luminescence.
400. The apparatus of any one of claims 335-338, 342-346 or 354-359, wherein said source of electrical energy is adapted to provide a voltage scan.
401. The apparatus of any one of claims 336-338, 341-343, 345-351, 353 or 355-360, wherein said apparatus is adapted to contact a plurality of sectors on said plate and selectively apply electrical energy to each of said sectors sequentially.
402. The apparatus of any one of claims 335-338, 344, or 346, wherein said electrical connections contact said multi-well plate by pushing up on said plate bottom.
403. The apparatus of any one of claims 337, 338, 344, 345, or 346, wherein said support comprises one or more electrical connections adapted to provide electrical energy to said plurality of wells.
404. The apparatus of any one of claims 335-360, further comprising a conveyor adapted to convey said multi-well plate to a detection location where electrode induced luminescence is induced and/or measured.
405. The apparatus of any one of claims 335-360, further comprising a motion control computer adapted to control the motion of said multi-well plate or the motion of said support or the motion of said camera or the motion of said electrical connections.
406. The apparatus of any one of claims 335-360, further comprising a temperature sensor.
407. The apparatus of any one of claims 335-360, further comprising a temperature sensor adapted to contact said plate.
408. The apparatus of any one of claims 335-360, further comprising a non-contact sensor.
409. The apparatus of any preceding claim 335-408, further comprising a non-contact sensor having an infrared detector.
410. The apparatus of any one of claims 335-360, further comprising a temperature controller adapted to scan said multi-well plate for temperature variation and said apparatus is adapted to correct for temperature effects.
411. The apparatus of any one of claims 335-360, wherein said apparatus further comprises a light source adapted to induce fluorescence in wells of said multi-well plate.
412. The apparatus of any one of claims 335-360, further comprising dispensers for dispensing initiators and/or reagents into said wells.
413. The apparatus of any one of claims 340-346, wherein said imaging system comprises a camera.
414. The apparatus of claim 413, wherein said camera is an array of light detectors.
415. The apparatus of claim 413, wherein said camera is a CCD array.
416. The apparatus of claim 413, wherein said camera is a CMOS detector array.
417. The apparatus of any one of claims 340-346, wherein said imaging system is adapted to measure and resolve luminescence from each of a plurality of binding domains within each well.
418. The apparatus of any one of claims 340-346, wherein said imaging system has a detecting surface on which an image is formed and wherein the width of said image is 50-200% of the width of said sector.
419. The apparatus of any one of claims 340-346, wherein said imaging system comprises a lens.
420. The apparatus of claim 419, wherein the diameter of the lens is between 3.0 and 5.0 inches.
421. The apparatus of claim 419, wherein said lens has a magnification of approximately 0.625 plus or minus 0.010.
422. The apparatus of any one of claims 340-346, wherein said imaging system comprises a low f-number telecentric lens.
423. The apparatus of claim 338, further comprising a tapered fiber bundle between said support and said light detector.
424. The apparatus of claim 338, further comprising an intensifier (MCP) between said support and said light detector.
425. The apparatus of any one of claims 335-360, further comprising a computer image analyzer.
426. The apparatus of claim 425, wherein said computer image analyzer is capable of correcting defective camera pixels.
427. The apparatus of any one of claims 335-360, further comprising a computer having software for locating said wells, subtracting background light and/or eliminating cosmic rays induced artifacts.
428. The apparatus of any one of claims 335-360, wherein said apparatus comprises an input port and an output port.
429. The apparatus of any one of claims 335-360, further comprising an integral bar code reader for positive sample identification.
430. The apparatus of any one of claims 335-360, further comprising a robotic arm for placing said multi-well plate onto a plate conveyor and for removing said multi-well plate from said plate conveyor.
431. The apparatus of any one of claims 335-360, further comprising a multi-well plate stacker.
432. The apparatus of claims 335, 338, 339 or 347-353, wherein said light detector comprises one or more photodiodes.
433. The apparatus of claims 335, 338, 339 or 347-353, wherein said light detector comprises an array of detectors configured so that one detector is aligned with one well during the measurement.
434. The apparatus of claim 433, wherein said array of light detectors is configured to measure light from a row or column of wells simultaneously.
435. The apparatus of claim 433, wherein said array of light detectors is a linear array of light detectors.
436. The apparatus of any one of claims 335-360, further comprising a linear array of electrical connections.
437. The apparatus of any one of claims 335-360, further comprising four working electrical connections and three counter electrical connections.
438. The method of any one of claims 361-367 or 369-379, wherein said measuring of said luminescence comprises measuring luminescence from each well using at least one light detector aligned with each well being measured.
439. The method of any one of claims 361-379, wherein less than 2% of luminescence is cross-talk luminescence.
440. The method of any one of claims 361-379, wherein less than 1% of luminescence is cross-talk luminescence.
441. The method of any one of claims 361-379, wherein less than 0.5% of luminescence is cross-talk luminescence.
442. The method of any one of claims 361-379, wherein less than 0.1% of luminescence is cross-talk luminescence.
443. The method of any one of claims 361-379, further comprising selecting a specified spectrum of emission of luminescence.
444. The method of any one of claims 361-379, further comprising subtracting background light and/or eliminating cosmic ray induced artifacts.
445. The method of any one of claims 361-379, comprising measuring background luminescence prior to inducing luminescence from said plurality of wells and subsequently measuring induced luminescence.
446. The method of any one of claims 361-379, further comprising contacting said multi-well plate with one or more working electrical connections and one or more counter electrical connections.
447. The method of any one of claims 361-379, further comprising inducing photoluminescence in one or more wells using a light source and measuring said photoluminescence from said wells.
448. The method of any one of claims 361-379, further comprising adding an initiator to one or more wells and measuring emitted chemiluminescence.
449. The method of any of claims 361-368, 373, or 374, comprising positioning a camera to image said multi-well plate.
450. The method of any of claims 361-368, 373, or 374, further comprising positioning said multi-well plate to be imaged by a camera.
451. The method of claim 369, further comprising positioning said multi-well plate to allow a first sector to be imaged by said imaging system, further positioning said multi-well plate to allow a second sector to be imaged by said imaging system.
452. The method of any one of claims 361-379, comprising imaging said multi-well plate to confirm proper detection positioning and subsequently inducing luminescence and measuring emitted luminescence.
453. The method of any one of claims 361-379, comprising locating said wells using a computer.
454. The method of any one of claims 361-371 or 373-379, wherein said measuring is performed by scanning said multi-well plate linearly.
455. The method of any one of claims 361-379, wherein said measuring is performed using film.
456. The method of any one of claims 361-379, wherein said measuring is performed using one or more photodiodes.
457. The method of any one of claims 361-367, 372, or 375-379, wherein said measuring is performed using an array of photodiodes.
458. The method of any one of claims 361-367, 372, or 375-379, comprising positioning one or more photodiodes to measure light from said multi-well plate.
459. The method of any one of claims 361, 362, 363, 364, or 365, further comprising positioning said multi-well plate so that emitted luminescence may be measured by a light detector.
460. The method of any one of claims 375-379, further comprising positioning said multi-well plate so that emitted luminescence from a first row or column of wells may be measured by said light detectors and further positioning said multi-well plate so that a second row or column of wells may be measured by said light detectors.
461. The method of any one of claims 375-379, wherein said wells are separately addressable and each light detector measures luminescence from two or more of said separately addressable wells.
462. The method of any one of claims 361-379, comprising carrying said multi-well plate to a detection position via an apparatus opening, forming a light tight enclosure by closing said opening, measuring emitted luminescence, opening said opening and subsequently removing said multi-well plate.
463. The method of claim 462, comprising placing said multi-well plate onto a drawer, which retracts into said light tight enclosure.
464. The method of any one of claims 361-365, further comprising carrying said multi-well plate and/or positioning a light detector using a motion control computer.
465. The method of any one of claims 361-379, further comprising removing said multi-well plates from a multi-well stack and carrying said multi-well plate to a detection position and re-stacking said multi-well plates after said measuring.
466. The method of any of claims 361-379, further comprising adding one or more luminescence reagents to one or more of said wells.
467. The method of claim 466, wherein said one or more luminescence reagents is selected from the group of: (a) at least one luminescent label;
(b) at least one electrochemiluminescence coreactant; (c) one or more binding reagents; (d) a pH
buffer; and (e) enzymes.
(b) at least one electrochemiluminescence coreactant; (c) one or more binding reagents; (d) a pH
buffer; and (e) enzymes.
468. The method of claim 466, wherein said one or more luminescence reagents is selected from the group of: (a) at least one luminescent label;
and (b) at least one electrochemiluninescence coreactant.
and (b) at least one electrochemiluninescence coreactant.
469. The method of any one of claims 361-379, further comprising shaking said multi-well plate to increase the rate of specific binding.
470. The method of any one of claims 361-379, further comprising an assay wash step.
471. The method of any one of claims 361-379, wherein luminescence from at least 20 multi-well plates is sequentially measured automatically.
472. The apparatus of any one of claims 335-360, further comprising one or more robotic devices and/or computer systems capable of performing one or more of the following functions: (a) moving the plates into, within and out of said apparatus;
(b) storing the plates in a suitable environment; (c) liquid or reagent handling device;
(d) assay plate shaker; and (e) plate aspiration.
(b) storing the plates in a suitable environment; (c) liquid or reagent handling device;
(d) assay plate shaker; and (e) plate aspiration.
473. A method of flexibly identifying a plurality of machine-readable indicia, comprising:
reading indicia information from at least one of the plurality of machine-readable indicia; passing the indicia information to an indicia identifier;
identifying an appropriate indicia interpreter for the indicia information;
and processing the indicia information with the appropriate indicia interpreter.
reading indicia information from at least one of the plurality of machine-readable indicia; passing the indicia information to an indicia identifier;
identifying an appropriate indicia interpreter for the indicia information;
and processing the indicia information with the appropriate indicia interpreter.
474. A method of flexibly identifying a plurality of machine-readable indicia, the method comprising the steps of:
(a) reading a unique instance of indicia information from the plurality of machine-readable indicia;
(b) passing the indicia information read in step (a) to a plurality of indicia interpreters;
(c) identifying an appropriate indicia interpreter for the indicia information passed from step (b);
(d) interpreting the indicia information passed from step (b) with the appropriate indicia interpreter identified in step (c); and (e) repeating steps (a) through (d) for each unique instance of indicia information.
(a) reading a unique instance of indicia information from the plurality of machine-readable indicia;
(b) passing the indicia information read in step (a) to a plurality of indicia interpreters;
(c) identifying an appropriate indicia interpreter for the indicia information passed from step (b);
(d) interpreting the indicia information passed from step (b) with the appropriate indicia interpreter identified in step (c); and (e) repeating steps (a) through (d) for each unique instance of indicia information.
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1181720A (en) * | 1995-04-25 | 1998-05-13 | 伊萝莉公司 | Remotely programmable matrices with memories and uses thereof |
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
CA2434139C (en) * | 2001-01-23 | 2014-05-27 | President And Fellows Of Harvard College | Nucleic-acid programmable protein arrays |
WO2002100460A2 (en) | 2001-06-12 | 2002-12-19 | Pelikan Technologies, Inc. | Electric lancet actuator |
US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
US7041068B2 (en) * | 2001-06-12 | 2006-05-09 | Pelikan Technologies, Inc. | Sampling module device and method |
AU2002348683A1 (en) | 2001-06-12 | 2002-12-23 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
DK2420824T3 (en) * | 2001-06-29 | 2019-03-25 | Meso Scale Technologies Llc | Multi-well plate with an array of wells and kit for use in performing an ECL assay |
ATE471369T1 (en) * | 2001-07-30 | 2010-07-15 | Meso Scale Technologies Llc | ASSAY ELECTRODES WITH LAYERS OF IMMOBILIZED LIPID/PROTEIN AND METHOD FOR THE PRODUCTION AND USE THEREOF |
US7063946B2 (en) * | 2001-09-10 | 2006-06-20 | Meso Scale Technologies, Llc. | Methods, reagents, kits and apparatus for protein function analysis |
US7067269B2 (en) * | 2001-11-26 | 2006-06-27 | Echelon Biosciences, Inc. | Assaying apparatus, kit, and method for lipids and associated enzymes |
US7632467B1 (en) * | 2001-12-13 | 2009-12-15 | Kardex Engineering, Inc. | Apparatus for automated storage and retrieval of miniature shelf keeping units |
JP3951743B2 (en) * | 2002-02-28 | 2007-08-01 | 松下電器産業株式会社 | Semiconductor device and manufacturing method thereof |
US20030165409A1 (en) * | 2002-03-04 | 2003-09-04 | Polymicro Technologies, Llc | Device and method for manipulating or dispensing multiple filaments |
US8442689B2 (en) * | 2002-03-11 | 2013-05-14 | Craig P. Lovell | System for flexibly representing and processing assay plates |
DE10214250A1 (en) * | 2002-03-30 | 2003-10-23 | Hans-Joachim Galla | Microtitration plate has a transparent base plate with an optically transparent and electrically conductive coating, supporting a multiple-wave superstructure to define the cavities, held by a release bond |
US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US7175642B2 (en) | 2002-04-19 | 2007-02-13 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
US7708701B2 (en) | 2002-04-19 | 2010-05-04 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device |
US8360992B2 (en) | 2002-04-19 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
US7229458B2 (en) * | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
US8372016B2 (en) | 2002-04-19 | 2013-02-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling and analyte sensing |
US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
US20040034177A1 (en) * | 2002-05-02 | 2004-02-19 | Jian Chen | Polymer and method for using the polymer for solubilizing nanotubes |
WO2004001404A1 (en) * | 2002-06-19 | 2003-12-31 | Becton, Dickinson And Company | Microfabricated sensor arrays |
US20040005572A1 (en) * | 2002-07-05 | 2004-01-08 | Rosner S. Jeffrey | Electronically readable microarrays |
US8263375B2 (en) | 2002-12-20 | 2012-09-11 | Acea Biosciences | Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology |
US7470533B2 (en) * | 2002-12-20 | 2008-12-30 | Acea Biosciences | Impedance based devices and methods for use in assays |
US7560269B2 (en) | 2002-12-20 | 2009-07-14 | Acea Biosciences, Inc. | Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays |
US7745203B2 (en) * | 2002-07-31 | 2010-06-29 | Kabushiki Kaisha Toshiba | Base sequence detection apparatus and base sequence automatic analyzing apparatus |
DE10236029A1 (en) * | 2002-08-02 | 2004-02-19 | Cybio Systems Gmbh | Device for dispensing and monitoring the luminescence of individual samples in multi-sample arrangements |
AU2003278987A1 (en) * | 2002-09-26 | 2004-04-19 | The Children's Hospital Of Philadelphia | Method of determining surface binding capacity |
US7608682B2 (en) | 2002-10-30 | 2009-10-27 | Meso Scale Technologies Llc | Substrates of N-end rule ubiquitylation and methods for measuring the ubiquitylation of these substrates |
US20030153013A1 (en) * | 2002-11-07 | 2003-08-14 | Ruo-Pan Huang | Antibody-based protein array system |
US20040095615A1 (en) * | 2002-11-14 | 2004-05-20 | Chung-Hua Tsai | Biological scanner with two dimensional scanning operation |
US11346797B2 (en) | 2002-12-20 | 2022-05-31 | Agilent Technologies, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties |
US10539523B2 (en) | 2002-12-20 | 2020-01-21 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties |
US10215748B2 (en) | 2002-12-20 | 2019-02-26 | Acea Biosciences, Inc. | Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways |
US10551371B2 (en) | 2003-11-10 | 2020-02-04 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function |
EP1608952B1 (en) * | 2002-12-20 | 2016-08-10 | Life Technologies Corporation | Assay apparatus and method using microfluidic arrays |
AU2003293562A1 (en) * | 2002-12-26 | 2004-07-22 | Meso Scale Technologies, Llc | Methods, compositions and kits for biomarker extraction |
US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
US7070260B2 (en) * | 2003-01-09 | 2006-07-04 | Labcyte Inc. | Droplet dispensation from a reservoir with reduction in uncontrolled electrostatic charge |
US20040218804A1 (en) * | 2003-01-31 | 2004-11-04 | Affleck Rhett L. | Image analysis system and method |
JP3787631B2 (en) * | 2003-03-07 | 2006-06-21 | 国立大学法人名古屋大学 | Bioluminescence measurement / analysis program, computer-readable recording medium storing the program, and bioluminescence measurement / analysis apparatus including the program and the computer |
JP3710452B2 (en) * | 2003-03-11 | 2005-10-26 | キヤノン株式会社 | Image reading apparatus, data interpolation method, and control program |
CN1813023A (en) * | 2003-05-22 | 2006-08-02 | 塞威公司 | Nanocomposites and methods thereto |
ES2347248T3 (en) * | 2003-05-30 | 2010-10-27 | Pelikan Technologies Inc. | PROCEDURE AND APPLIANCE FOR FLUID INJECTION. |
US20050099615A1 (en) * | 2003-06-03 | 2005-05-12 | Fusao Ishii | System for fabricating electronic modules on substrates having arbitrary and unexpected dimensional changes |
US7850621B2 (en) | 2003-06-06 | 2010-12-14 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
US8092643B2 (en) * | 2003-06-16 | 2012-01-10 | Ionfield Systems, Llc | Method and apparatus for cleaning and surface conditioning objects using plasma |
US8092644B2 (en) * | 2003-06-16 | 2012-01-10 | Ionfield Systems, Llc | Method and apparatus for cleaning and surface conditioning objects using plasma |
US6921670B2 (en) * | 2003-06-24 | 2005-07-26 | Hewlett-Packard Development Company, Lp. | Nanostructure fabrication using microbial mandrel |
US7282180B2 (en) * | 2003-07-02 | 2007-10-16 | Immunivest Corporation | Devices and methods to image objects |
SE527166C2 (en) * | 2003-08-21 | 2006-01-10 | Kerttu Eriksson | Method and apparatus for dehumidification |
US20060013984A1 (en) * | 2003-09-19 | 2006-01-19 | Donald Sandell | Film preparation for seal applicator |
US20050280811A1 (en) * | 2003-09-19 | 2005-12-22 | Donald Sandell | Grooved high density plate |
WO2005029041A2 (en) * | 2003-09-19 | 2005-03-31 | Applera Corporation | High density sequence detection methods and apparatus |
US7570443B2 (en) | 2003-09-19 | 2009-08-04 | Applied Biosystems, Llc | Optical camera alignment |
US20050232818A1 (en) * | 2003-09-19 | 2005-10-20 | Donald Sandell | Single sheet seal applicator and cartridge |
US20060011305A1 (en) * | 2003-09-19 | 2006-01-19 | Donald Sandell | Automated seal applicator |
US20050226780A1 (en) * | 2003-09-19 | 2005-10-13 | Donald Sandell | Manual seal applicator |
EP1670945A2 (en) * | 2003-09-19 | 2006-06-21 | Applera Corporation | Microplates useful for conducting thermocycled nucleotide amplification |
US20050225751A1 (en) * | 2003-09-19 | 2005-10-13 | Donald Sandell | Two-piece high density plate |
WO2005033659A2 (en) | 2003-09-29 | 2005-04-14 | Pelikan Technologies, Inc. | Method and apparatus for an improved sample capture device |
US9351680B2 (en) | 2003-10-14 | 2016-05-31 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a variable user interface |
US7981362B2 (en) | 2003-11-04 | 2011-07-19 | Meso Scale Technologies, Llc | Modular assay plates, reader systems and methods for test measurements |
CA2550274A1 (en) | 2003-11-12 | 2005-05-26 | Acea Biosciences, Inc. | Real time electronic cell sensing systems and applications for cell-based assays |
JP3950972B2 (en) * | 2003-11-14 | 2007-08-01 | 国立大学法人名古屋大学 | Bioluminescence measuring device for biological samples |
US20050244811A1 (en) * | 2003-12-15 | 2005-11-03 | Nano-Proprietary, Inc. | Matrix array nanobiosensor |
US7341834B2 (en) * | 2003-12-15 | 2008-03-11 | Geneohn Sciences, Inc. | Multiplexed electrochemical detection system and method |
US8668656B2 (en) | 2003-12-31 | 2014-03-11 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for improving fluidic flow and sample capture |
US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
US20080312555A1 (en) * | 2004-02-06 | 2008-12-18 | Dirk Boecker | Devices and methods for glucose measurement using rechargeable battery energy sources |
US20050186578A1 (en) * | 2004-02-20 | 2005-08-25 | Sven Bulow | Chamber array arrangement |
JP2005283304A (en) * | 2004-03-29 | 2005-10-13 | Lintec Corp | Probe array |
US7384779B2 (en) | 2004-04-12 | 2008-06-10 | Corning Incorporated | Porous substrate plates and the use thereof |
KR20060133099A (en) * | 2004-04-13 | 2006-12-22 | 지벡스 코포레이션 | Methods for the synthesis of modular poly(phenyleneethynylenes) and fine tuning the electronic properties thereof for the functionalization of nanomaterials |
CA2563168A1 (en) * | 2004-04-14 | 2005-11-17 | President And Fellows Of Harvard College | Nucleic-acid programmable protein arrays |
US7796266B2 (en) | 2004-04-30 | 2010-09-14 | Kimberly-Clark Worldwide, Inc. | Optical detection system using electromagnetic radiation to detect presence or quantity of analyte |
US7815854B2 (en) | 2004-04-30 | 2010-10-19 | Kimberly-Clark Worldwide, Inc. | Electroluminescent illumination source for optical detection systems |
US7152736B1 (en) * | 2004-05-03 | 2006-12-26 | Menichini Frank A | Foam material specimen transport apparatus |
US8828203B2 (en) | 2004-05-20 | 2014-09-09 | Sanofi-Aventis Deutschland Gmbh | Printable hydrogels for biosensors |
US7497133B2 (en) | 2004-05-24 | 2009-03-03 | Drexel University | All electric piezoelectric finger sensor (PEFS) for soft material stiffness measurement |
US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
EP1765194A4 (en) | 2004-06-03 | 2010-09-29 | Pelikan Technologies Inc | Method and apparatus for a fluid sampling device |
US7480042B1 (en) * | 2004-06-30 | 2009-01-20 | Applied Biosystems Inc. | Luminescence reference standards |
WO2007013872A2 (en) | 2004-07-22 | 2007-02-01 | The Board Of Trustees Of The University Of Illinois | Sensors employing single-walled carbon nanotubes |
US7296576B2 (en) * | 2004-08-18 | 2007-11-20 | Zyvex Performance Materials, Llc | Polymers for enhanced solubility of nanomaterials, compositions and methods therefor |
JP4750394B2 (en) * | 2004-09-10 | 2011-08-17 | 三菱化学メディエンス株式会社 | Multilayer electrode and multilayer electrode cartridge, electrochemical analysis device and electrochemical analysis method, electrochemiluminescence analysis device and electrochemiluminescence analysis method |
US20060065532A1 (en) * | 2004-09-30 | 2006-03-30 | Matthias Stiene | Microfluidic analytical system with accessible electrically conductive contact pads |
US7704730B2 (en) * | 2004-10-14 | 2010-04-27 | Meso Scale Technologies, Llc | Multiplexed assay methods |
CA2587945A1 (en) * | 2004-11-17 | 2007-04-12 | Bioveris | Electrochemiluminescent assay |
EP1816503B1 (en) * | 2004-11-26 | 2017-11-08 | Olympus Corporation | Luminescent sample imaging method |
US20060205012A1 (en) * | 2004-12-09 | 2006-09-14 | Meso Scale Technologies, Llc | Diagnostic test |
US7688364B2 (en) * | 2004-12-10 | 2010-03-30 | Ambarella, Inc. | Decimating and cropping based zoom factor for a digital camera |
US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
AU2006206515A1 (en) * | 2005-01-19 | 2006-07-27 | Irm Llc | Multi-well container positioning devices, systems, computer program products, and methods |
US20060199221A1 (en) * | 2005-03-07 | 2006-09-07 | Samad Talebpour | Correction for temperature dependence assays |
CN104525072A (en) * | 2005-03-23 | 2015-04-22 | 维罗西股份有限公司 | Surface features in microprocess technology |
US20060216203A1 (en) * | 2005-03-28 | 2006-09-28 | Mds Sciex (Us) A Division Of Mds Pharma Services (Us) Inc. | Multiwell sample plate with integrated impedance electrodes and connection scheme |
ATE475886T1 (en) * | 2005-04-12 | 2010-08-15 | Sru Biosystems Inc | PROTEOLIPID MEMBRANE AND LIPID MEMBRANE BIOSENSOR |
JP4964229B2 (en) * | 2005-05-04 | 2012-06-27 | テカン・トレーディング・アクチェンゲゼルシャフト | Apparatus and method for moving a liquid container |
US8033501B2 (en) * | 2005-06-10 | 2011-10-11 | The Boeing Company | Method and apparatus for attaching electrically powered seat track cover to through hole seat track design |
DE102005027407B3 (en) * | 2005-06-13 | 2006-11-09 | Eppendorf Ag | Thermo cycler, for polymerase chain reactions, comprises a cover over the holding zone for the reaction vessels with a sealing wall adjusted longitudinally by an external setting unit |
CN100406874C (en) * | 2005-06-20 | 2008-07-30 | 北京源德生物医学工程有限公司 | Gate module of semi automatic single photon counting meter of micropore plate |
WO2007011844A1 (en) * | 2005-07-19 | 2007-01-25 | Physical Sciences, Inc. | Side view imaging microwell array |
US8735142B2 (en) * | 2005-08-16 | 2014-05-27 | Chipotle Business Group, Inc. | Systems and methods for immunosorbent assays for single and multiple analytes |
WO2007044711A1 (en) * | 2005-10-07 | 2007-04-19 | University Of Florida Research Foundation, Inc. | Multiple component nanoparticles for multiplexed signaling and optical encoding |
FR2891924B1 (en) * | 2005-10-10 | 2007-12-28 | Biospace Mesures | LUMINESCENCE IMAGING DEVICE AND METHOD |
MX364297B (en) | 2005-12-21 | 2019-04-22 | Meso Scale Technologies Llc | Assay modules having assay reagents and methods of making and using same. |
MX338460B (en) | 2005-12-21 | 2016-04-15 | Meso Scale Technologies Llc | Assay apparatuses, methods and reagents. |
US9322783B2 (en) | 2005-12-21 | 2016-04-26 | Meso Scale Technologies, Llc | Replaceable detection module and an apparatus for conducting luminescence assays |
AU2012202574B2 (en) * | 2005-12-21 | 2015-11-12 | Meso Scale Technologies, Llc | Assay Apparatuses, Methods and Reagents |
US8185319B2 (en) * | 2006-01-19 | 2012-05-22 | Novx Systems Canada Inc. | Method of compensation of dose-response curve of an assay for sensitivity to perturbing variables |
US20070172395A1 (en) * | 2006-01-20 | 2007-07-26 | Applera Corporation | Thermally Conductive Microplate |
US20090278556A1 (en) * | 2006-01-26 | 2009-11-12 | Nanoselect, Inc. | Carbon Nanostructure Electrode Based Sensors: Devices, Processes and Uses Thereof |
WO2007089550A2 (en) | 2006-01-26 | 2007-08-09 | Nanoselect, Inc. | Cnt-based sensors: devices, processes and uses thereof |
US20070207275A1 (en) * | 2006-02-21 | 2007-09-06 | Applied Materials, Inc. | Enhancement of remote plasma source clean for dielectric films |
WO2007106402A2 (en) * | 2006-03-10 | 2007-09-20 | President And Fellows Of Harvard College | Methods and apparatus for near field irradiation |
WO2007106833A2 (en) * | 2006-03-13 | 2007-09-20 | Sage Science, Inc. | Laboratory reagent and sample assembly, management and processing |
US20080031774A1 (en) * | 2006-03-13 | 2008-02-07 | Sage Science, Inc. | Apparatus for Guiding Sample and Reagent Manipulations and Receptacles for Holding Same |
JP5220623B2 (en) * | 2006-03-16 | 2013-06-26 | ユニバーサル ナノセンサー テクノロジーズ インコーポレーテッド | Dielectric constant detection method and system |
WO2008054480A2 (en) * | 2006-03-22 | 2008-05-08 | Northrop Grumman Corporation | Enhanced biohazard detection system |
WO2007121324A1 (en) * | 2006-04-12 | 2007-10-25 | Sage Science, Inc. | Apparatus for guiding sample and reagent manipulations and receptacles for holding same |
US20070255506A1 (en) * | 2006-04-26 | 2007-11-01 | Affymetrix, Inc. | System, Method, and Computer Product for Instrument Control and Management of Consumable Resources |
JP2009537021A (en) * | 2006-05-12 | 2009-10-22 | ベリデックス・リミテッド・ライアビリティ・カンパニー | Laser irradiation system in fluorescence microscopy |
US20080006202A1 (en) * | 2006-06-26 | 2008-01-10 | Applera Corporation | Compressible transparent sealing for open microplates |
US8178316B2 (en) * | 2006-06-29 | 2012-05-15 | President And Fellows Of Harvard College | Evaluating proteins |
US7629124B2 (en) * | 2006-06-30 | 2009-12-08 | Canon U.S. Life Sciences, Inc. | Real-time PCR in micro-channels |
WO2008006060A1 (en) * | 2006-07-07 | 2008-01-10 | Drexel University | Electrical insulation of devices with thin layers |
US10001486B2 (en) * | 2006-08-08 | 2018-06-19 | Alverix, Inc. | Method of using differential measurement in two or more channels to improve sensitivity |
US8020573B2 (en) * | 2006-08-10 | 2011-09-20 | Avago Technologies Wireless Ip (Singapore) Pte. Ltd. | Microfluidic channels and reservoirs in portable electronic devices |
US7715699B2 (en) * | 2006-08-10 | 2010-05-11 | Avago Technologies Wireless Ip (Singapore) Pte. Ltd. | Electrically addressable liquid dispenser |
TWI328984B (en) * | 2006-08-29 | 2010-08-11 | Ind Tech Res Inst | Substrate structures and fabrication methods thereof |
AU2007297484B2 (en) * | 2006-09-18 | 2013-07-18 | Global Life Sciences Solutions Usa Llc | Preparation of glassified biological reagents |
US8481335B2 (en) * | 2006-11-27 | 2013-07-09 | Drexel University | Specificity and sensitivity enhancement in cantilever sensing |
WO2008067386A2 (en) | 2006-11-28 | 2008-06-05 | Drexel University | Piezoelectric microcantilever sensors for biosensing |
US7992431B2 (en) | 2006-11-28 | 2011-08-09 | Drexel University | Piezoelectric microcantilevers and uses in atomic force microscopy |
DE102007004953A1 (en) * | 2007-01-26 | 2008-07-31 | Tesa Ag | heating element |
US20080243415A1 (en) * | 2007-01-30 | 2008-10-02 | Applera Corporation | Calibrating the Positions of a Rotating and Translating Two-Dimensional Scanner |
JP2010518380A (en) | 2007-02-01 | 2010-05-27 | ドレクセル・ユニバーシティー | Handheld phase shift detector for sensor applications |
WO2008130463A2 (en) * | 2007-02-06 | 2008-10-30 | The Trustees Of The University Of Pennsylvania | Multiplexed nanoscale electrochemical sensors for multi-analyte detection |
US9557217B2 (en) | 2007-02-13 | 2017-01-31 | Bti Holdings, Inc. | Universal multidetection system for microplates |
DE112008000507T5 (en) * | 2007-02-26 | 2010-02-18 | Wisconsin Alumni Research Foundation, Madison | Surface plasmon resonance compatible carbon thin films |
EP2140267B1 (en) * | 2007-02-26 | 2017-11-15 | StemCell Technologies Inc. | Method of reducing curvature in a meniscus of liquid medium |
CA2680897A1 (en) * | 2007-03-29 | 2008-10-09 | Response Biomedical Corporation | Modular assay reader system and apparatus |
AU2008101286A4 (en) * | 2007-05-14 | 2011-12-15 | Erie Scientific Company | Multiwell plate device |
WO2008154225A2 (en) * | 2007-06-06 | 2008-12-18 | Bayer Healthcare Llc | Microdeposition system for a biosensor |
ES2363406T3 (en) * | 2007-06-29 | 2011-08-03 | Unisense Fertilitech A/S | DEVICE, SYSTEM AND METHOD FOR MONITORING AND / OR CULTIVATING MICROSCOPIC OBJECTS. |
JP2010533840A (en) * | 2007-07-13 | 2010-10-28 | ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニヴァーシティ | Methods and apparatus using electric fields for improved biological assays |
EP2030683B1 (en) * | 2007-08-17 | 2013-10-02 | Qiagen GmbH | Device and method for removing substances from pre-filled containers |
US8053198B2 (en) * | 2007-09-14 | 2011-11-08 | Meso Scale Technologies, Llc | Diagnostic methods |
SG188082A1 (en) | 2007-10-02 | 2013-03-28 | Theranos Inc | Modular point-of-care devices and uses thereof |
US20090139311A1 (en) | 2007-10-05 | 2009-06-04 | Applied Biosystems Inc. | Biological Analysis Systems, Devices, and Methods |
US20090181359A1 (en) * | 2007-10-25 | 2009-07-16 | Lou Sheng C | Method of performing ultra-sensitive immunoassays |
US8222048B2 (en) | 2007-11-05 | 2012-07-17 | Abbott Laboratories | Automated analyzer for clinical laboratory |
WO2009079154A2 (en) | 2007-11-23 | 2009-06-25 | Drexel University | Lead-free piezoelectric ceramic films and a method for making thereof |
US9551026B2 (en) | 2007-12-03 | 2017-01-24 | Complete Genomincs, Inc. | Method for nucleic acid detection using voltage enhancement |
GB0724736D0 (en) * | 2007-12-19 | 2008-01-30 | Oxford Nanolabs Ltd | Formation of layers of amphiphilic molecules |
US7946056B2 (en) * | 2008-01-23 | 2011-05-24 | Kroll Family Trust | Ambulatory hairdryer |
GB0802568D0 (en) * | 2008-02-12 | 2008-03-19 | Optima Design Services Ltd | Particle separation apparatus and methods |
US8741663B2 (en) | 2008-03-11 | 2014-06-03 | Drexel University | Enhanced detection sensitivity with piezoelectric sensors |
CN101539571B (en) * | 2008-03-20 | 2013-08-21 | 长春吉大·小天鹅仪器有限公司 | Array-type 96-channel rapid detector for pesticide residue |
US9386944B2 (en) | 2008-04-11 | 2016-07-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte detecting device |
KR101725340B1 (en) | 2008-04-11 | 2017-04-26 | 메소 스케일 테크놀러지즈, 엘엘시 | Assay apparatuses, methods and reagents |
EP2279421B1 (en) * | 2008-04-23 | 2019-07-03 | GE Healthcare Bio-Sciences AB | Positioning of dispensing means in fraction collector |
WO2009137440A1 (en) | 2008-05-05 | 2009-11-12 | Acea Biosciences, Inc. | Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution |
CN102066928B (en) | 2008-05-16 | 2015-08-05 | 德瑞索大学 | The system and method for assessment tissue |
WO2009154710A2 (en) * | 2008-06-19 | 2009-12-23 | Plexigen, Inc. | Multi-dimensional fluid sensors and related detectors and methods |
US8286561B2 (en) | 2008-06-27 | 2012-10-16 | Ssw Holding Company, Inc. | Spill containing refrigerator shelf assembly |
WO2009158567A1 (en) * | 2008-06-27 | 2009-12-30 | Ssw Holding Company, Inc. | Method for spill containment and shelves or the like therefore |
US11786036B2 (en) | 2008-06-27 | 2023-10-17 | Ssw Advanced Technologies, Llc | Spill containing refrigerator shelf assembly |
JP5176235B2 (en) * | 2008-07-03 | 2013-04-03 | 国立大学法人東北大学 | Electrochemical measuring device |
US20100021941A1 (en) * | 2008-07-25 | 2010-01-28 | Progenra, Incorporated | Methods of identifying modulators of ubiquitin ligases |
US20100022416A1 (en) * | 2008-07-25 | 2010-01-28 | Life Bioscience, Inc. | Assay plates, methods and systems having one or more etched features |
US7950582B2 (en) * | 2008-08-26 | 2011-05-31 | Ncr Corporation | Method of producing a coated optical element |
CA2678570C (en) * | 2008-09-12 | 2016-08-16 | Stemcell Technologies Inc. | Cell culture vessels for meniscus reduction with aqueous solutions |
WO2010034013A1 (en) * | 2008-09-22 | 2010-03-25 | Helixis Inc. | Devices and methods for visualization of a sample in a microplate |
US7984567B2 (en) * | 2008-10-07 | 2011-07-26 | Christ Bill Bertakis | Apparatus for cleaning simulated hair articles |
US9921101B2 (en) * | 2008-10-09 | 2018-03-20 | Douglas Scientific, LLC | Scanner photometer and methods |
IT1392250B1 (en) * | 2008-12-02 | 2012-02-22 | Univ Degli Studi Torino | PROCEDURE AND KIT FOR THE DETECTION OF HUMAN OR ANIMAL BLOOD ON A SURFACE. |
US9057568B2 (en) | 2008-12-16 | 2015-06-16 | California Institute Of Technology | Temperature control devices and methods |
US8264689B1 (en) * | 2008-12-22 | 2012-09-11 | ISC8 Inc. | Micro gas cell array device and method |
EP2208780B1 (en) | 2009-01-20 | 2017-11-01 | Lonza Cologne GmbH | Method and device for electric processing of multiple containers |
EP2389247B1 (en) | 2009-01-23 | 2017-03-01 | Biotix, Inc. | Anti-static pipette tip trays |
FI20095063A0 (en) | 2009-01-26 | 2009-01-26 | Wallac Oy | Optical measuring instrument |
FI20095061A0 (en) * | 2009-01-26 | 2009-01-26 | Wallac Oy | Master module for an optical measuring instrument |
FI20095059A0 (en) * | 2009-01-26 | 2009-01-26 | Wallac Oy | Apparatus and method for optical measurement of samples |
GB2467338A (en) * | 2009-01-30 | 2010-08-04 | Sharp Kk | Electrical analyte sensor with optical output |
US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
CN101533009B (en) * | 2009-04-15 | 2015-07-08 | 徐恩良 | Micropore structure of microplate strip |
US20120046197A1 (en) | 2009-05-01 | 2012-02-23 | Meso Scale Technologies, Llc | Biomarkers of therapeutic responsiveness |
WO2010132208A2 (en) | 2009-05-13 | 2010-11-18 | Meso Scale Technologies, Llc | Diagnostic methods for liver disorders |
WO2010149587A2 (en) | 2009-06-23 | 2010-12-29 | Seereal Technologies S.A. | Light modulation device for a display for representing two- and/or three-dimensional image content |
JP5625269B2 (en) * | 2009-06-25 | 2014-11-19 | 大日本印刷株式会社 | Cell observation sample stand kit, cell observation sample stand, and method for manufacturing cell observation sample stand |
US9381515B2 (en) | 2009-07-24 | 2016-07-05 | Nipro Corporation | Container for measuring cell potential |
WO2011010721A1 (en) * | 2009-07-24 | 2011-01-27 | ニプロ株式会社 | Container for measuring cell potential and method for producing same |
WO2011017082A2 (en) | 2009-07-27 | 2011-02-10 | Clinton Charles M | Assay information management methods and devices |
WO2011017094A2 (en) | 2009-07-27 | 2011-02-10 | Ian Chamberlin | Assay apparatuses, consumables and methods |
US9523701B2 (en) | 2009-07-29 | 2016-12-20 | Dynex Technologies, Inc. | Sample plate systems and methods |
GB0913258D0 (en) | 2009-07-29 | 2009-09-02 | Dynex Technologies Inc | Reagent dispenser |
US8570370B2 (en) | 2009-08-31 | 2013-10-29 | Bio-Rad Laboratories, Inc. | Compact automated cell counter |
FI20096021A0 (en) | 2009-10-06 | 2009-10-06 | Wallac Oy | Optical measuring instrument |
US20110086368A1 (en) * | 2009-10-08 | 2011-04-14 | Drexel University | Method for immune response detection |
US8722427B2 (en) * | 2009-10-08 | 2014-05-13 | Drexel University | Determination of dissociation constants using piezoelectric microcantilevers |
WO2011047044A2 (en) * | 2009-10-13 | 2011-04-21 | Enrique Saez | A miniaturized electroporation-ready microwell array for high-throughput genomic screening |
WO2011068057A1 (en) * | 2009-12-01 | 2011-06-09 | ニプロ株式会社 | Cellular potential measurement container and production method therefor |
US20110132911A1 (en) * | 2009-12-05 | 2011-06-09 | Dr. Jiandong Zhang | Biological Specimen Organizer |
US8980550B2 (en) * | 2009-12-15 | 2015-03-17 | California Institute Of Technology | Methods for measuring samples using consumer electronic devices and systems |
CN203069604U (en) * | 2010-02-22 | 2013-07-17 | 珀金埃尔默保健科学公司 | Microplate mounting system |
US20170118880A1 (en) * | 2010-03-24 | 2017-04-27 | Duetto Integrated Systems, Inc. | Supplemental lighting for reading information on circuit boards for use with a bond head assembly system |
US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US10295539B2 (en) | 2010-04-19 | 2019-05-21 | Meso Scale Technologies, Llc. | Serology assays |
EP2566949B1 (en) * | 2010-05-06 | 2023-02-15 | Charm Sciences, Inc. | Reader-incubator apparatus |
WO2011146531A1 (en) | 2010-05-18 | 2011-11-24 | Acea Biosciences, Inc | Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (rtca) cardio instruments |
WO2011149485A1 (en) * | 2010-05-28 | 2011-12-01 | E. I. Du Pont De Nemours And Company | Process for producing standardized assay areas on organic coatings |
US9535029B2 (en) * | 2010-06-11 | 2017-01-03 | Labmaster Oy | Low-cost electrode chip variants and methods for multi analyte analysis and referencing based on cathodic electroluminescence |
CA2807807C (en) | 2010-07-27 | 2023-10-24 | Jacob N. Wohlstadter | Consumable data management |
US20140057362A1 (en) * | 2010-08-26 | 2014-02-27 | Robert J. Markovsky | Lateral flow assay analysis |
WO2012034094A2 (en) | 2010-09-09 | 2012-03-15 | The Regents Of The University Of California | Integrated microfluidic radioassay and imaging platform for small sample analysis |
WO2012051519A2 (en) | 2010-10-14 | 2012-04-19 | The Johns Hopkins University | Biomarkers of brain injury |
US9731297B2 (en) | 2011-01-06 | 2017-08-15 | Meso Scale Technologies, Llc. | Assay cartridges and methods of using the same |
JP5508246B2 (en) * | 2010-12-20 | 2014-05-28 | 株式会社日本医学臨床検査研究所 | Aggregation reaction information input processing system and method |
CN103261393A (en) * | 2010-12-22 | 2013-08-21 | 株式会社日立制作所 | Culture substrate and culture sheet |
US9233369B2 (en) | 2010-12-23 | 2016-01-12 | California Institute Of Technology | Fluidic devices and fabrication methods for microfluidics |
US8968585B2 (en) | 2010-12-23 | 2015-03-03 | California Institute Of Technology | Methods of fabrication of cartridges for biological analysis |
US8493569B2 (en) * | 2010-12-27 | 2013-07-23 | Mitutoyo Corporation | Optical encoder readhead configuration with phosphor layer |
US20120184028A1 (en) * | 2011-01-19 | 2012-07-19 | John Robert Swanson | Micro IVF chamber |
TWI690594B (en) | 2011-01-21 | 2020-04-11 | 美商賽瑞諾斯Ip有限責任公司 | Systems and methods for sample use maximization |
US9529008B2 (en) | 2011-03-03 | 2016-12-27 | Life Technologies Corporation | Sampling probes, systems, apparatuses, and methods |
EP2683822B1 (en) | 2011-03-10 | 2020-04-22 | General Atomics | Diagnostic and sample preparation devices and methods |
WO2012125906A1 (en) * | 2011-03-16 | 2012-09-20 | Solidus Biosciences, Inc. | Apparatus and method for analyzing data of cell chips |
CN102279423B (en) * | 2011-04-09 | 2012-11-28 | 无锡精工泰创电气有限公司 | Fault self diagnosis apparatus for photoelectric area sensor channel and method thereof |
US9018584B2 (en) * | 2011-04-14 | 2015-04-28 | Emd Millipore Corporation | Devices and methods for infrared (IR) based quantitation of biomolecules |
WO2012155134A2 (en) | 2011-05-12 | 2012-11-15 | The Johns Hopkins University | Assay reagents for a neurogranin diagnostic kit |
WO2013033080A1 (en) * | 2011-08-29 | 2013-03-07 | Wayne State University | Device and method for optimizing photobiological processes |
US8475739B2 (en) | 2011-09-25 | 2013-07-02 | Theranos, Inc. | Systems and methods for fluid handling |
US9664702B2 (en) | 2011-09-25 | 2017-05-30 | Theranos, Inc. | Fluid handling apparatus and configurations |
US9632102B2 (en) | 2011-09-25 | 2017-04-25 | Theranos, Inc. | Systems and methods for multi-purpose analysis |
US20140170735A1 (en) | 2011-09-25 | 2014-06-19 | Elizabeth A. Holmes | Systems and methods for multi-analysis |
US9484123B2 (en) | 2011-09-16 | 2016-11-01 | Prc-Desoto International, Inc. | Conductive sealant compositions |
US10012664B2 (en) | 2011-09-25 | 2018-07-03 | Theranos Ip Company, Llc | Systems and methods for fluid and component handling |
US9810704B2 (en) | 2013-02-18 | 2017-11-07 | Theranos, Inc. | Systems and methods for multi-analysis |
EP2761294B1 (en) | 2011-09-29 | 2019-02-27 | Meso Scale Technologies, LLC | Biodosimetry panels and methods |
WO2013060482A1 (en) * | 2011-10-28 | 2013-05-02 | Torsten Matthias | Device and method for detecting substances present in biological or chemical samples |
US10837879B2 (en) | 2011-11-02 | 2020-11-17 | Complete Genomics, Inc. | Treatment for stabilizing nucleic acid arrays |
AU2012340870B2 (en) * | 2011-11-22 | 2015-07-30 | Siemens Healthcare Diagnostics Inc. | Interdigitated array and method of manufacture |
US20130164217A1 (en) | 2011-12-21 | 2013-06-27 | Meso Scale Technologies, Llc | Method of diagnosing, preventing and/or treating dementia & related disorders |
US8883088B2 (en) | 2011-12-23 | 2014-11-11 | California Institute Of Technology | Sample preparation devices and systems |
US9518291B2 (en) | 2011-12-23 | 2016-12-13 | California Institute Of Technology | Devices and methods for biological sample-to-answer and analysis |
ES2672268T3 (en) * | 2012-01-10 | 2018-06-13 | Idexx Laboratories, Inc. | Slides for immunoassay tests |
CA3191015A1 (en) | 2012-02-07 | 2013-08-15 | Vibrant Holdings, Llc | Substrates, peptide arrays, and methods |
GB201202519D0 (en) | 2012-02-13 | 2012-03-28 | Oxford Nanopore Tech Ltd | Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules |
EP2825867B1 (en) * | 2012-03-15 | 2020-01-01 | Bio-Rad Laboratories, Inc. | Image acquisition for chemiluminescent samples |
US9058648B2 (en) | 2012-03-15 | 2015-06-16 | Bio-Rad Laboratories, Inc. | Image acquisition for chemiluminescent samples |
US10168292B2 (en) * | 2012-03-22 | 2019-01-01 | California Institute Of Technology | Nanoscale calorimeter on chip and related methods and devices |
WO2013163129A1 (en) * | 2012-04-23 | 2013-10-31 | Siemens Healthcare Diagnostics Inc. | Biological assay sample analyzer |
US9625465B2 (en) | 2012-05-15 | 2017-04-18 | Defined Diagnostics, Llc | Clinical diagnostic systems |
US9213043B2 (en) | 2012-05-15 | 2015-12-15 | Wellstat Diagnostics, Llc | Clinical diagnostic system including instrument and cartridge |
US9081001B2 (en) | 2012-05-15 | 2015-07-14 | Wellstat Diagnostics, Llc | Diagnostic systems and instruments |
US9217179B2 (en) | 2012-05-24 | 2015-12-22 | The Governing Council Of The University Of Toronto | Systems and methods for multiplexed electrochemical detection |
EP2852820B1 (en) * | 2012-05-31 | 2023-05-03 | Agilent Technologies, Inc. | Universal multi-detection system for microplates |
US20130335716A1 (en) * | 2012-06-07 | 2013-12-19 | Mind Flow Llc | Projection Graphics Using One-Way Vision Screens |
US9530618B2 (en) * | 2012-07-06 | 2016-12-27 | Infineon Technologies Ag | Plasma system, chuck and method of making a semiconductor device |
CN104641235B (en) * | 2012-07-24 | 2017-10-03 | Fio公司 | Immune detection quick diagnosis test Gneral analysis device, system, method and computer-readable medium |
KR101428994B1 (en) | 2012-08-28 | 2014-08-13 | 엘지디스플레이 주식회사 | Touch Panel and Method of manufacturing the same and Display Device using the same |
US10006909B2 (en) | 2012-09-28 | 2018-06-26 | Vibrant Holdings, Llc | Methods, systems, and arrays for biomolecular analysis |
AU2013329415A1 (en) | 2012-10-08 | 2015-04-23 | University of Virginia Patent Foundation, d/b/a University of Virginia Licensing & Ventures Group | Miniaturized multiwell plate reader for phenotypic screening |
US20140113536A1 (en) * | 2012-10-23 | 2014-04-24 | Visteon Global Technologies, Inc. | Zonal airflow system for a vehicle |
US9423234B2 (en) | 2012-11-05 | 2016-08-23 | The Regents Of The University Of California | Mechanical phenotyping of single cells: high throughput quantitative detection and sorting |
WO2014071253A1 (en) | 2012-11-05 | 2014-05-08 | California Institute Of Technology | Instruments for biological sample-to-answer devices |
KR20140058969A (en) * | 2012-11-07 | 2014-05-15 | 한국전자통신연구원 | Light emitting diode and method for manufacturing the same |
US10286376B2 (en) | 2012-11-14 | 2019-05-14 | Vibrant Holdings, Llc | Substrates, systems, and methods for array synthesis and biomolecular analysis |
CN103017910A (en) * | 2012-11-30 | 2013-04-03 | 中国科学院上海技术物理研究所 | Light-transmitting baffle for quality inspection device of multi-path pyroelectric infrared sensor |
FR2999288B1 (en) * | 2012-12-11 | 2016-01-08 | Envolure | MICROPLATE READER DEVICE |
JP2014130962A (en) * | 2012-12-28 | 2014-07-10 | Ibiden Co Ltd | Formation method for cavity, formation device for cavity, program, manufacturing method for wiring board, and wiring board |
EP2941648A4 (en) | 2013-01-03 | 2016-11-09 | Meso Scale Technologies Llc | Assay panels |
DK2941633T3 (en) * | 2013-01-04 | 2024-04-02 | Meso Scale Technologies Llc | ASSAY APPARATUS, METHODS AND REAGENTS |
US9931633B2 (en) | 2013-01-10 | 2018-04-03 | Stemcell Technologies Inc. | Meniscus reducing member |
US10537891B2 (en) | 2013-01-10 | 2020-01-21 | Stemcell Technologies Inc. | Meniscus reducing member |
US20140221368A1 (en) | 2013-02-01 | 2014-08-07 | Meso Scale Technologies, Llc | Biomarkers of therapeutic responsiveness |
US20140220006A1 (en) * | 2013-02-01 | 2014-08-07 | Meso Scale Technologies, Llc | Lung cancer biomarkers |
US20140309263A1 (en) | 2013-02-01 | 2014-10-16 | Meso Scale Technologies, Llc | Biomarkers of therapeutic responsiveness |
EP2956771B1 (en) * | 2013-02-15 | 2020-04-08 | Vibrant Holdings, LLC | Methods and compositions for amplified electrochemiluminescence detection |
US10401373B1 (en) | 2013-02-18 | 2019-09-03 | Theranos Ip Company, Llc | Systems and methods for analyte testing and laboratory oversight |
US11008628B1 (en) | 2013-02-18 | 2021-05-18 | Labrador Diagnostics Llc | Systems and methods for analyte testing and laboratory oversight |
WO2014164594A1 (en) | 2013-03-11 | 2014-10-09 | Meso Scale Technologies, Llc. | Improved methods for conducting multiplexed assays |
US9440313B2 (en) * | 2013-03-12 | 2016-09-13 | Serenity Data Security, Llc | Hard drive data destroying device |
KR20220038550A (en) | 2013-03-13 | 2022-03-28 | 메소 스케일 테크놀러지즈, 엘엘시 | Improved assay methods |
US10114015B2 (en) | 2013-03-13 | 2018-10-30 | Meso Scale Technologies, Llc. | Assay methods |
AU2013202805B2 (en) * | 2013-03-14 | 2015-07-16 | Gen-Probe Incorporated | System and method for extending the capabilities of a diagnostic analyzer |
US9513303B2 (en) | 2013-03-15 | 2016-12-06 | Abbott Laboratories | Light-blocking system for a diagnostic analyzer |
BR112015023775B1 (en) | 2013-03-15 | 2022-08-16 | Lubrizol Advanced Materials, Inc | HEAVY METAL-FREE CPVC COMPOSITIONS |
US9632103B2 (en) | 2013-03-15 | 2017-04-25 | Abbott Laboraties | Linear track diagnostic analyzer |
WO2014144133A1 (en) * | 2013-03-15 | 2014-09-18 | The Trustees Of The Princeton University | Analyte detection enhancement by targeted immobilization, surface amplification, and pixelated reading and analysis |
WO2014144825A2 (en) | 2013-03-15 | 2014-09-18 | Abbott Laboratories | Automated reagent manager of a diagnostic analyzer system |
US9504981B2 (en) * | 2013-05-15 | 2016-11-29 | True Health Diagnostics Llc | Methods for purifying nucleic acids and devices thereof |
ITMI20130958A1 (en) * | 2013-06-11 | 2014-12-12 | Altergon Sa | DEVICE AND METHOD OF IDENTIFICATION AND MONITORING OF A KIT OF REAGENTS OF AN ANALYTICAL SYSTEM |
EP3757226A3 (en) | 2013-07-17 | 2021-05-05 | The Johns Hopkins University | A multi-protein biomarker assay for brain injury detection and outcome |
US10422806B1 (en) | 2013-07-25 | 2019-09-24 | Theranos Ip Company, Llc | Methods for improving assays of biological samples |
US20150038365A1 (en) | 2013-08-01 | 2015-02-05 | Meso Scale Technologies, Llc | Lung cancer biomarkers |
TWI503172B (en) * | 2013-09-03 | 2015-10-11 | Nat Univ Tsing Hua | Assay assembly |
US20160313317A1 (en) * | 2013-09-30 | 2016-10-27 | Empire Technology Development Llc | Biomolecular detection using multiphoton plasmonic cooperative coupling |
CN103499571B (en) * | 2013-10-14 | 2016-03-23 | 南京大学 | A kind of electrochemiluminescdetection detection device |
US10131610B2 (en) | 2013-10-25 | 2018-11-20 | Empire Technology Development Llc | Methods of producing dicarbonyl compounds |
US9827566B2 (en) * | 2013-11-19 | 2017-11-28 | IDEA machine development design AND production ltd. | Multi-well plates and methods of use thereof |
US9387451B2 (en) | 2014-02-03 | 2016-07-12 | International Business Machines Corporation | Flow cell array and uses thereof |
GB2523135A (en) * | 2014-02-13 | 2015-08-19 | Molecular Vision Ltd | Assay device |
US11360107B1 (en) | 2014-02-25 | 2022-06-14 | Labrador Diagnostics Llc | Systems and methods for sample handling |
US10895563B2 (en) | 2014-02-26 | 2021-01-19 | Trace-Ability, Inc. | Palette-based systems for analyte characterization |
TWI482963B (en) * | 2014-03-05 | 2015-05-01 | Coretronic Corp | Hydrophilic film and manufacturing method thereof, and organism sensor using the hydrophilic film |
WO2015143387A1 (en) | 2014-03-21 | 2015-09-24 | Maxim Demetrios Samuel | Portable instrument for in vitro detection and quantification of biomarkers |
US10665377B2 (en) | 2014-05-05 | 2020-05-26 | 3D Glass Solutions, Inc. | 2D and 3D inductors antenna and transformers fabricating photoactive substrates |
WO2015171971A1 (en) * | 2014-05-09 | 2015-11-12 | Meso Scale Technologies, Llc. | Graphene-modified electrodes |
KR20230022268A (en) | 2014-05-15 | 2023-02-14 | 메소 스케일 테크놀러지즈, 엘엘시 | Improved assay methods |
EP3092474B1 (en) | 2014-06-12 | 2020-04-22 | Axion Biosystems, Inc. | Multiwell microelectrode array with optical stimulation |
US20150362420A1 (en) * | 2014-06-13 | 2015-12-17 | Wafergen, Inc. | Systems for single or multiple cell counting and dispensing |
JP6549355B2 (en) | 2014-06-16 | 2019-07-24 | 株式会社エンプラス | Fluid handling device |
WO2016044697A1 (en) | 2014-09-19 | 2016-03-24 | The Johns Hopkins University | Biomarkers of cognitive dysfunction |
EP3212761A1 (en) * | 2014-10-29 | 2017-09-06 | Corning Incorporated | Microwell design and fabrication for generation of cell culture aggregates |
JP2016094238A (en) * | 2014-11-17 | 2016-05-26 | セイコーエプソン株式会社 | Container housing body |
CN104407395A (en) * | 2014-12-06 | 2015-03-11 | 周振 | Infrared sensing microplate indicator |
US9996920B2 (en) * | 2014-12-09 | 2018-06-12 | Berkeley Lights, Inc. | Automated detection and repositioning of micro-objects in microfluidic devices |
US10730053B2 (en) | 2014-12-10 | 2020-08-04 | Biotix, Inc. | Static-defeating apparatus for pipette tips |
USD849962S1 (en) | 2014-12-10 | 2019-05-28 | Biotix, Inc. | Pipette tip retention sheet |
USD865216S1 (en) | 2014-12-10 | 2019-10-29 | Biotix, Inc. | Pipette tip sheet |
USD815753S1 (en) | 2014-12-10 | 2018-04-17 | Biotix, Inc. | Pipette tip sheet |
US10137453B2 (en) | 2014-12-10 | 2018-11-27 | Biotix, Inc. | Static-defeating apparatus for pipette tips |
WO2016101033A1 (en) * | 2014-12-23 | 2016-06-30 | Commonwealth Scientific And Industrial Research Organisation | Electrochemical testing system |
WO2016104517A1 (en) * | 2014-12-26 | 2016-06-30 | 株式会社 東芝 | Biosensor |
US9470611B2 (en) * | 2015-01-13 | 2016-10-18 | Gilson, Inc. | Sample plate for sliding magnetic particle separation |
US9518903B2 (en) | 2015-01-13 | 2016-12-13 | Gilson, Inc. | Adapter for sliding magnetic particle separation |
US10036739B2 (en) * | 2015-01-27 | 2018-07-31 | Genia Technologies, Inc. | Adjustable bilayer capacitance structure for biomedical devices |
US10908083B2 (en) * | 2015-02-02 | 2021-02-02 | Hitachi High-Tech Corporation | Multicolor fluorescence analysis device |
JP6363527B2 (en) * | 2015-02-06 | 2018-07-25 | シチズンファインデバイス株式会社 | Sample loading plate |
WO2016130962A1 (en) | 2015-02-13 | 2016-08-18 | Abbott Laboratories | Automated storage modules for diagnostic analyzer liquids and related systems and methods |
WO2016134365A1 (en) | 2015-02-20 | 2016-08-25 | The Johns Hopkins University | Biomarkers of myocardial injury |
KR20220018612A (en) | 2015-04-06 | 2022-02-15 | 메소 스케일 테크놀러지즈, 엘엘시 | High throughput system for performing assays using electrochemiluminescence including a consumable shaking apparatus |
CN104897657A (en) * | 2015-06-26 | 2015-09-09 | 朱金国 | Method for detecting electrochemiluminescence by aid of suspending electrodes and microporous plates |
US11300579B2 (en) * | 2015-07-23 | 2022-04-12 | Meso Scale Technologies, Llc. | Integrated consumable data management system and platform |
WO2018017156A1 (en) | 2016-07-22 | 2018-01-25 | Meso Scale Technologies, Llc. | Integrated consumable data management system & platform |
DE102015214414B4 (en) * | 2015-07-29 | 2020-10-22 | Berthold Technologies Gmbh & Co. Kg | Method and system for determining biological properties of samples |
US10809243B2 (en) | 2015-08-31 | 2020-10-20 | Roche Sequencing Solutions, Inc. | Small aperture large electrode cell |
US11369966B2 (en) * | 2015-09-18 | 2022-06-28 | Arizona Board Of Regents On Behalf Of Arizona State University | Layered structure for improved sealing of microwell arrays |
US10070533B2 (en) | 2015-09-30 | 2018-09-04 | 3D Glass Solutions, Inc. | Photo-definable glass with integrated electronics and ground plane |
US11058093B2 (en) * | 2015-10-30 | 2021-07-13 | Brandeis University | Systems and methods for monitoring and controlling drosophila activity |
US20170131234A1 (en) * | 2015-11-10 | 2017-05-11 | Woodham Biotechnology Holdings, LLC | Gel Electrophoresis and Transfer Combination using Conductive Polymers and Method of Use |
RU2723936C2 (en) * | 2015-11-10 | 2020-06-18 | ВУДХЭМ БАЙОТЕКНОЛОДЖИ ХОДИНГЗ, ЭлЭлСи | Combination of gel electrophoresis and transfer using conducting polymers and method of using |
US20170144373A1 (en) * | 2015-11-23 | 2017-05-25 | Battelle Memorial Institute | Method and system for three-dimensional printing of conductive materials |
GB201522323D0 (en) | 2015-12-17 | 2016-02-03 | Vrije Universiteit Brussel And Katholieke Universiteit Leuven | Systems and methods for conducting electrochemical impedance spectroscopy |
FR3045827B1 (en) * | 2015-12-18 | 2018-01-12 | Biomerieux | ANALYSIS CUP AND DERIVATIVES WITH SIGNAL AMPLIFICATION |
JP2019508222A (en) * | 2015-12-22 | 2019-03-28 | スリーエム イノベイティブ プロパティズ カンパニー | Stem-well film for sample distribution |
US10337967B2 (en) * | 2016-01-08 | 2019-07-02 | Salus Discovery Llc | Magnetic base for collection and release of paramagnetic particles |
US10281405B2 (en) * | 2016-01-08 | 2019-05-07 | Clemson University Research Foundation | Ambient desorption-optical emission spectroscopy using a microplasma desorption/excitation source |
US10436781B2 (en) * | 2016-01-27 | 2019-10-08 | Paratus Diagnostics, LLC | Point-of-care diagnostic cartridge having a digital micro-fluidic testing substrate |
EP3420571A4 (en) | 2016-02-25 | 2020-03-25 | 3D Glass Solutions, Inc. | 3d capacitor and capacitor array fabricating photoactive substrates |
USD1006251S1 (en) * | 2016-03-18 | 2023-11-28 | Meso Scale Technologies, Llc. | Rack and label |
USD889685S1 (en) * | 2016-03-18 | 2020-07-07 | Meso Scale Technologies, Llc. | Reagent rack cover |
USD882818S1 (en) * | 2016-03-18 | 2020-04-28 | Meso Scale Technologies, Llc. | Reagent rack |
WO2017177171A1 (en) | 2016-04-08 | 2017-10-12 | 3D Glass Solutions, Inc. | Methods of fabricating photosensitive substrates suitable for optical coupler |
CN105934100B (en) * | 2016-06-24 | 2018-04-24 | 中山市金玛印刷机械有限公司 | Full-automatic double-face screen printer |
KR101839686B1 (en) | 2016-06-27 | 2018-03-16 | 한국과학기술원 | Method, system and non-transitory computer-readable recording medium for monitoring hemodynamics |
GB201611770D0 (en) | 2016-07-06 | 2016-08-17 | Oxford Nanopore Tech | Microfluidic device |
USD867614S1 (en) * | 2016-07-23 | 2019-11-19 | Meso Scale Technologies, Llc. | Plate lids |
EP3300803B1 (en) * | 2016-09-30 | 2019-05-15 | F. Hoffmann-La Roche AG | Analytical system with accurate positioning of multiwell plates |
IL267009B (en) | 2016-12-01 | 2022-07-01 | Berkeley Lights Inc | Automated detection and repositioning of micro-objects in microfluidic devices |
US20190315011A1 (en) * | 2016-12-01 | 2019-10-17 | 3M Innovative Properties Company | Alignment of Film in a Conversion Station |
CN108431603B (en) | 2016-12-28 | 2020-04-21 | 纽勤有限公司 | Fluid stop cartridge assembly and method of use |
GB201704769D0 (en) | 2017-01-03 | 2017-05-10 | Illumina Inc | Flowcell cartridge with floating seal bracket |
US10662466B2 (en) * | 2017-01-18 | 2020-05-26 | Salus Discovery, LLC | Magnetic base for collection and release of paramagnetic particles |
WO2018136797A1 (en) | 2017-01-19 | 2018-07-26 | Indevr, Inc. | Parallel imaging system |
DE102017102385A1 (en) * | 2017-02-07 | 2018-08-09 | Weber Maschinenbau Gmbh Breidenbach | Gripper, cutting device and method of cutting a product |
CA3053301A1 (en) * | 2017-02-16 | 2018-08-23 | Essenlix Corporation | Assay with textured surface |
CN106846340B (en) * | 2017-02-17 | 2019-06-21 | 大连理工大学 | A kind of striation boundary extraction method based on on-fixed characteristic point |
EP3589299A4 (en) | 2017-03-03 | 2021-01-13 | ACEA Biosciences, Inc. | METHODS AND SYSTEMS FOR FUNCTIONAL MATURATION OF iPSC AND ESC DERIVED CARDIOMYOCYTES |
AU2018240463B2 (en) * | 2017-03-24 | 2023-06-29 | Gen-Probe Incorporated | Systems and methods for capacitive fluid level detection, and handling containers |
US10730141B2 (en) * | 2017-04-07 | 2020-08-04 | Branson Ultrasonics Corporation | Optical feedback signal compensation for background infrared radiation in a laser chamber |
JP6966860B2 (en) * | 2017-04-07 | 2021-11-17 | リンテック株式会社 | Manufacturing method of inspection cover film, inspection member, and inspection cover film |
WO2018200804A1 (en) | 2017-04-28 | 2018-11-01 | 3D Glass Solutions, Inc. | Rf circulator |
US10777503B2 (en) * | 2017-05-11 | 2020-09-15 | Schweizer Electronic Ag | Method for contacting a metallic contact pad in a printed circuit board and printed circuit board |
PL238767B1 (en) * | 2017-05-22 | 2021-10-04 | Slaski Univ Medyczny W Katowicach | System for acquiring of a biofilm for the SEM electron microscopy analysis |
US10538808B2 (en) | 2017-05-26 | 2020-01-21 | Vibrant Holdings, Llc | Photoactive compounds and methods for biomolecule detection and sequencing |
GB201709140D0 (en) * | 2017-06-08 | 2017-07-26 | Vitrolife As | Lid for culture dish |
CN107271433B (en) * | 2017-06-28 | 2019-07-30 | 苏州长光华医生物医学工程有限公司 | A kind of luminous measurement method of single reaction cup |
JP6903270B2 (en) | 2017-06-29 | 2021-07-14 | 株式会社Nsテクノロジーズ | Electronic component transfer device and electronic component inspection device |
JP2019011961A (en) * | 2017-06-29 | 2019-01-24 | セイコーエプソン株式会社 | Electronic component conveying device and electronic component inspection device |
WO2019010045A1 (en) | 2017-07-07 | 2019-01-10 | 3D Glass Solutions, Inc. | 2d and 3d rf lumped element devices for rf system in a package photoactive glass substrates |
JP2019027922A (en) | 2017-07-31 | 2019-02-21 | セイコーエプソン株式会社 | Electronic component conveyance device and electronic component inspection device |
US11117128B2 (en) * | 2017-08-25 | 2021-09-14 | Vanadis Diagnostics Ab | Filtration device |
JP6974087B2 (en) * | 2017-09-14 | 2021-12-01 | 株式会社ディスコ | Cutting equipment |
CN107734272B (en) * | 2017-09-30 | 2020-02-11 | 京东方科技集团股份有限公司 | Mask plate detection equipment, mask plate detection method and corresponding light source control method |
US10260033B1 (en) * | 2017-10-06 | 2019-04-16 | Wyatt Technology Corporation | Method and apparatus to mitigate evaporation in high throughput measurements |
DE102017218262B4 (en) * | 2017-10-12 | 2019-05-29 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | A method of making a device for sensor-based examination of biological cells, fabricated device and uses thereof |
CN107589425B (en) * | 2017-10-17 | 2019-11-26 | 广州极飞科技有限公司 | Ultrasonic distance measurement equipment and its detection of the backscatter signal method, apparatus and aircraft |
EP3697303B1 (en) * | 2017-10-20 | 2023-03-08 | Rutgers, the State University of New Jersey | Transcutaneous wearable apparatus for continuous monitoring of biomarkers in blood |
JP7008824B2 (en) | 2017-12-15 | 2022-01-25 | スリーディー グラス ソリューションズ,インク | Connection transmission line resonant RF filter |
US11677373B2 (en) | 2018-01-04 | 2023-06-13 | 3D Glass Solutions, Inc. | Impedence matching conductive structure for high efficiency RF circuits |
US11251032B2 (en) | 2018-02-09 | 2022-02-15 | Hamamatsu Photonics K.K. | Sample support |
EP4310184A3 (en) | 2018-02-23 | 2024-05-01 | Meso Scale Technologies, LLC. | Methods of screening antigen-binding molecules by normalizing for the concentration of antigen-binding molecule |
CA3093455A1 (en) | 2018-03-08 | 2019-09-12 | Meso Scale Technologies, Llc. | Genetic marker and/or biomarkers for traumatic brain injury, and ultrasensitive assays for biomarkers of traumatic brain injury |
EP3643148A4 (en) | 2018-04-10 | 2021-03-31 | 3D Glass Solutions, Inc. | Rf integrated power condition capacitor |
DE102018207560A1 (en) * | 2018-05-16 | 2019-11-21 | Henkel Ag & Co. Kgaa | Determination of reductive damage of hair with NIR spectroscopy |
WO2019222708A2 (en) | 2018-05-17 | 2019-11-21 | Meso Scale Technologies, Llc. | Methods for isolating surface marker displaying agents |
CN108732215B (en) * | 2018-05-18 | 2020-04-03 | 厦门大学 | Electrochemical in-situ spectrum electrolytic cell and application |
GB2574048B (en) * | 2018-05-24 | 2021-06-16 | Oxford Nanopore Tech Ltd | Nanopore sensor component with electrostatic discharge protection |
WO2019231947A1 (en) | 2018-05-29 | 2019-12-05 | 3D Glass Solutions, Inc. | Low insertion loss rf transmission line |
BR112020024715A2 (en) | 2018-06-04 | 2021-03-23 | Avon Products. Inc. | protein biomarkers to identify and treat skin aging and skin conditions |
US10383606B1 (en) * | 2018-07-16 | 2019-08-20 | Bloom Health, Inc. | Toilet based urine analysis system |
WO2020018592A1 (en) | 2018-07-17 | 2020-01-23 | Methodical Mind, Llc. | Graphical user interface system |
US20210138453A1 (en) * | 2018-07-26 | 2021-05-13 | Hewlett-Packard Development Company, L.P. | Non-uniform electrical field to position objects |
CN108982619B (en) * | 2018-08-06 | 2024-02-27 | 中国科学院地球化学研究所 | Eh chemical sensor for high-pressure hydrothermal system and preparation method thereof |
US20210102899A1 (en) * | 2018-08-28 | 2021-04-08 | Lloyd Ploof | Chemically and Biologically Reactive Microplate Assembly and Manufacture Thereof for Raman Spectroscopy and Other Applications |
EP3853944B1 (en) | 2018-09-17 | 2023-08-02 | 3D Glass Solutions, Inc. | High efficiency compact slotted antenna with a ground plane |
WO2020086751A1 (en) | 2018-10-23 | 2020-04-30 | Meso Scale Technologies, Llc. | Methods for isolating surface marker displaying agents |
US11543356B2 (en) | 2018-10-29 | 2023-01-03 | Hewlett-Packard Development Company, L.P. | Rotation and flat-form imaging for microscopic objects |
US20230048936A1 (en) * | 2018-11-22 | 2023-02-16 | Kaya17 Inc. | System and method for detecting presence of a target bioparticle in a sample via a vertical flow assay |
US11298701B2 (en) | 2018-11-26 | 2022-04-12 | King Instrumentation Technologies | Microtiter plate mixing control system |
BR112020026320A2 (en) * | 2018-12-17 | 2021-03-30 | Illumina, Inc. | FLOW CELLS, SEQUENCING KITS AND METHOD |
CN111351781B (en) * | 2018-12-20 | 2023-11-24 | 麦德龙生物株式会社 | Electrochemiluminescence analysis device and method for analyzing sample using the same |
JP7241433B2 (en) | 2018-12-28 | 2023-03-17 | スリーディー グラス ソリューションズ,インク | Heterogeneous Integration for RF, Microwave and MM Wave Systems on Photoactive Glass Substrates |
WO2020139955A1 (en) | 2018-12-28 | 2020-07-02 | 3D Glass Solutions, Inc. | Annular capacitor rf, microwave and mm wave systems |
WO2020142347A2 (en) * | 2018-12-31 | 2020-07-09 | Gen-Probe Incorporated | Systems and methods for filling multi-well cartridges with solid reagents |
JP2022515917A (en) | 2019-01-03 | 2022-02-22 | メソ スケール テクノロジーズ エルエルシー | Compositions and Methods for Performing Assay Measurements |
CN109459421B (en) * | 2019-01-16 | 2024-03-08 | 岳昆 | Serum vitamin A detection kit and detection method thereof |
JP7190167B2 (en) * | 2019-02-18 | 2022-12-15 | 大学共同利用機関法人自然科学研究機構 | measuring device |
US20220099661A1 (en) | 2019-03-01 | 2022-03-31 | Meso Scale Technologies, Llc. | Electrochemiluminescent labeled probes for use in immunoassay methods, methods using such and kits comprising same |
AU2020239385A1 (en) | 2019-03-12 | 2021-08-26 | Oxford Nanopore Technologies Plc | Nanopore sensing device and methods of operation and of forming it |
CN111751332A (en) * | 2019-03-28 | 2020-10-09 | 上海易孛特光电技术有限公司 | Method and device for imaging self-luminous object on biological sample film |
US10838556B2 (en) | 2019-04-05 | 2020-11-17 | Apple Inc. | Sensing system for detection of light incident to a light emitting layer of an electronic device display |
JP7140435B2 (en) | 2019-04-05 | 2022-09-21 | スリーディー グラス ソリューションズ,インク | Glass-based empty substrate integrated waveguide device |
US11373908B2 (en) | 2019-04-18 | 2022-06-28 | 3D Glass Solutions, Inc. | High efficiency die dicing and release |
KR20210154226A (en) * | 2019-04-23 | 2021-12-20 | 메소 스케일 테크놀러지즈, 엘엘시 | Analytical devices, methods, and reagents, including instruments and methods, for reducing crosstalk between CCD measurements |
CN114364815A (en) | 2019-05-03 | 2022-04-15 | 中尺度技术有限责任公司 | Kits for detecting one or more target analytes in a sample and methods of making and using same |
WO2020232425A1 (en) * | 2019-05-16 | 2020-11-19 | General Automation Lab Technologies Inc. | Method for assaying biological sample on microfabricated chip |
WO2021011630A1 (en) * | 2019-07-16 | 2021-01-21 | Meso Scale Technologies, Llc. | Assay apparatuses, methods and reagents |
CN110487803A (en) * | 2019-08-20 | 2019-11-22 | Oppo(重庆)智能科技有限公司 | The defect inspection method and device of infrared light-emitting component |
CN110456095A (en) * | 2019-08-22 | 2019-11-15 | 成都凡迪医学检验所有限公司 | Microfluid spot sample device |
US11890699B1 (en) * | 2019-09-19 | 2024-02-06 | Dustin Hawkins | Method of manufacturing a waterproof strapped accessory |
US11611058B2 (en) | 2019-09-24 | 2023-03-21 | Apple Inc. | Devices and systems for under display image sensor |
US11527582B1 (en) | 2019-09-24 | 2022-12-13 | Apple Inc. | Display stack with integrated photodetectors |
EP4055391A1 (en) | 2019-11-05 | 2022-09-14 | Meso Scale Technologies, LLC | Methods and kits for quantitating radiation exposure |
US11946847B2 (en) | 2019-11-14 | 2024-04-02 | Nok Corporation | Extracellular potential measurement device |
WO2021108666A2 (en) | 2019-11-26 | 2021-06-03 | Meso Scale Technologies, Llc. | Methods and kits for detecting autoimmune diseases |
AU2020419302A1 (en) | 2020-01-03 | 2022-06-23 | Meso Scale Technologies, Llc. | Device housing with lighting |
USD941488S1 (en) | 2020-02-07 | 2022-01-18 | Agilent Technologies, Inc. | Instrument for analyzing biological cells |
US11592873B2 (en) * | 2020-02-14 | 2023-02-28 | Apple Inc. | Display stack topologies for under-display optical transceivers |
US11295664B2 (en) | 2020-03-11 | 2022-04-05 | Apple Inc. | Display-synchronized optical emitters and transceivers |
KR20220164800A (en) | 2020-04-17 | 2022-12-13 | 3디 글래스 솔루션즈 인코포레이티드 | broadband inductor |
US20230184768A1 (en) | 2020-05-01 | 2023-06-15 | Meso Scale Technologies, Llc. | Viral serology ace2 competition assays |
WO2021236584A1 (en) | 2020-05-19 | 2021-11-25 | Meso Scale Technologies, Llc. | Methods, compositions, and kits for nucleic acid detection |
JP7303397B2 (en) * | 2020-05-20 | 2023-07-04 | ワイエスアイ,インコーポレイティド | Spatial gradient-based fluorometer |
US20210370296A1 (en) * | 2020-05-26 | 2021-12-02 | Bio-Rad Laboratories, Inc. | Apparatus and method for fast digital detection |
US11327237B2 (en) | 2020-06-18 | 2022-05-10 | Apple Inc. | Display-adjacent optical emission or reception using optical fibers |
AU2021299536A1 (en) | 2020-07-01 | 2023-02-16 | Meso Scale Technologies, Llc. | Compositions and methods for assay measurements |
CN111812171B (en) * | 2020-07-15 | 2022-04-15 | 哈尔滨工业大学(深圳) | Integrated photoelectrochemical sensing electrode and application thereof |
EP3943924A1 (en) * | 2020-07-22 | 2022-01-26 | Technische Universität München | Microwell plate for impedance measurements on cell clusters |
US11487859B2 (en) | 2020-07-31 | 2022-11-01 | Apple Inc. | Behind display polarized optical transceiver |
DE102020120790B4 (en) | 2020-08-06 | 2022-09-08 | Leica Microsystems Cms Gmbh | Inverted microscope with incubation space and temperature sensor |
TW202227813A (en) | 2020-08-21 | 2022-07-16 | 美商梅梭刻度技術公司 | Auxiliary electrodes and methods for using and manufacturing the same |
CA3193739A1 (en) | 2020-09-02 | 2022-03-10 | Meso Scale Technologies, Llc. | Kits for detecting one or more target analytes in a sample and methods of making and using the same |
EP4208720A2 (en) | 2020-09-04 | 2023-07-12 | Meso Scale Technologies, LLC | Methods for isolating central nervous system surface marker displaying agents |
US20220091065A1 (en) * | 2020-09-18 | 2022-03-24 | Visera Technologies Company Limited | Sensor device and method of using the same |
CN114247484B (en) * | 2020-09-24 | 2023-06-23 | 京东方科技集团股份有限公司 | Microfluidic device and microfluidic system |
US20230407223A1 (en) * | 2020-10-22 | 2023-12-21 | The Board Of Regents Of The University Of Texas System | High throughput micro-well array plates and methods of fabrication |
CN112275345A (en) * | 2020-10-31 | 2021-01-29 | 张晓东 | Net type combined beaker bracket and beaker moving device |
EP4271978A1 (en) * | 2020-12-31 | 2023-11-08 | Q-State Biosciences, Inc. | Microscope with spatial imaging and beam homogenizer |
CA3206969A1 (en) * | 2020-12-31 | 2022-07-07 | Q-State Biosciences, Inc. | Plate imager |
AU2022206320A1 (en) | 2021-01-11 | 2023-07-27 | Meso Scale Technologies, Llc. | Assay system calibration systems and methods |
EP4302089A1 (en) | 2021-03-01 | 2024-01-10 | Meso Scale Technologies, LLC | System and method for conducting a multiplexed assay |
US11839133B2 (en) | 2021-03-12 | 2023-12-05 | Apple Inc. | Organic photodetectors for in-cell optical sensing |
CA3216357A1 (en) * | 2021-04-09 | 2022-10-13 | Laboratory Corporation Of America Holdings | Methods and systems for improved quality assurance for high-throughput analysis |
EP4323546A1 (en) | 2021-04-16 | 2024-02-21 | Meso Scale Technologies, LLC | Methods, compositions, and kits for detecting hydrolase enzyme activity |
WO2022232027A1 (en) | 2021-04-26 | 2022-11-03 | Meso Scale Technologies, Llc. | Multi-plex assay plates and methods of making |
EP4330672A1 (en) | 2021-04-26 | 2024-03-06 | Meso Scale Technologies, LLC. | Methods for isolating and analyzing a target analyte encapsulated by a surface marker displaying agent |
US20220381780A1 (en) | 2021-05-21 | 2022-12-01 | Meso Scale Technologies, Llc. | Viral strain serology assays |
WO2022264416A1 (en) * | 2021-06-18 | 2022-12-22 | 株式会社日立ハイテク | Imaging system and imaging range adjustment method |
CN113390862A (en) * | 2021-06-21 | 2021-09-14 | 中国科学院长春应用化学研究所 | Electrochemical luminescence immunosensor and preparation method thereof |
IL309517A (en) | 2021-06-28 | 2024-02-01 | Meso Scale Technologies Llc | Methods, compositions, and kits for assay signal amplification |
CA3226777A1 (en) | 2021-07-21 | 2023-01-26 | Methodical Mind, Llc. | Graphical user interface system guide module |
TW202340716A (en) | 2021-08-13 | 2023-10-16 | 美商梅梭刻度技術公司 | Electrochemical cell devices and methods of manufacturing |
US20230141860A1 (en) | 2021-09-09 | 2023-05-11 | Meso Scale Technologies, Llc. | Method for detecting sense and antisense strands in an oligonucleotide duplex |
US20230111586A1 (en) * | 2021-10-12 | 2023-04-13 | Bio-Rad Laboratories, Inc. | Consumable for analyte detection |
US11870148B2 (en) * | 2021-11-11 | 2024-01-09 | Raytheon Company | Planar metal Fresnel millimeter-wave lens |
US20230279290A1 (en) | 2021-12-30 | 2023-09-07 | Meso Scale Technologies, Llc. | Compositions and methods for assay measurements |
US20230213476A1 (en) | 2022-01-04 | 2023-07-06 | Meso Scale Technologies, Llc. | Electrochemical cell devices and methods of manufacturing |
WO2023212315A2 (en) | 2022-04-29 | 2023-11-02 | Meso Scale Technologies, Llc. | Methods for detecting and isolating extracellular vesicles |
WO2023245184A1 (en) | 2022-06-17 | 2023-12-21 | Meso Scale Technologies, Llc. | Viral strain serology assays |
CN115218628B (en) * | 2022-07-19 | 2023-09-05 | 胜华新材料集团股份有限公司 | Drying device is used in preparation of silicon carbon negative pole piece |
EP4325207A1 (en) * | 2022-08-19 | 2024-02-21 | Leica Microsystems CMS GmbH | Imaging device |
WO2024064904A1 (en) | 2022-09-23 | 2024-03-28 | Meso Scale Technologies, Llc. | Orthopoxvirus serology assays |
CN116148459B (en) * | 2023-01-09 | 2024-02-23 | 浙江宝太智能科技有限公司 | Reading compensation method for chemiluminescent reader |
CN116465955B (en) * | 2023-03-10 | 2023-10-24 | 厦门金诺花科学仪器有限公司 | Nanoliter sample application instrument, reusable needle head and testing and regenerating methods thereof |
CN116579902B (en) * | 2023-04-07 | 2023-12-12 | 南京电力设计研究院有限公司 | Digital park electric carbon data mapping method, system, equipment and storage medium |
Family Cites Families (118)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57132038A (en) | 1981-02-10 | 1982-08-16 | Olympus Optical Co Ltd | Photometric device |
US4849330A (en) | 1984-04-27 | 1989-07-18 | Molecular Devices Corporation | Photoresponsive redox detection and discrimination |
US5310687A (en) | 1984-10-31 | 1994-05-10 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
US5238808A (en) | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
US5171560A (en) | 1984-12-06 | 1992-12-15 | Hyperion Catalysis International | Carbon fibrils, method for producing same, and encapsulated catalyst |
US5165909A (en) | 1984-12-06 | 1992-11-24 | Hyperion Catalysis Int'l., Inc. | Carbon fibrils and method for producing same |
US4663230A (en) | 1984-12-06 | 1987-05-05 | Hyperion Catalysis International, Inc. | Carbon fibrils, method for producing same and compositions containing same |
US5030310A (en) * | 1985-06-28 | 1991-07-09 | Miles Inc. | Electrode for electrochemical sensors |
US5147806A (en) | 1988-04-29 | 1992-09-15 | Igen, Inc. | Method and apparatus for conducting electrochemiluminescence measurements |
US6165729A (en) | 1986-04-30 | 2000-12-26 | Hyperion Catalysis International, Inc. | Electrochemiluminescent reaction utilizing amine-derived reductant |
EP0265519B1 (en) | 1986-04-30 | 1995-09-13 | IGEN, INC. (a California corporation) | Electrochemiluminescent assays |
US5770459A (en) | 1986-04-30 | 1998-06-23 | Igen International, Inc. | Methods and apparatus for improved luminescence assays using particle concentration, electrochemical generation of chemiluminescence detection |
US5591581A (en) | 1986-04-30 | 1997-01-07 | Igen, Inc. | Electrochemiluminescent rhenium moieties and methods for their use |
US5066372A (en) * | 1986-05-02 | 1991-11-19 | Ciba Corning Diagnostics Corp. | Unitary multiple electrode sensor |
US4894137A (en) * | 1986-09-12 | 1990-01-16 | Omron Tateisi Electronics Co. | Enzyme electrode |
US4933048A (en) | 1988-02-16 | 1990-06-12 | I-Stat Corporation | Reference electrode, method of making and method of using same |
US5308754A (en) | 1988-03-21 | 1994-05-03 | Kankare Jouko J | Electrogenerated luminescence in solution |
US5093268A (en) | 1988-04-28 | 1992-03-03 | Igen, Inc. | Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena |
US5218312A (en) * | 1988-07-20 | 1993-06-08 | Ricardo Moro | Measurement apparatus for measuring a biological substance within a fluid substrate |
US5705402A (en) | 1988-11-03 | 1998-01-06 | Igen International, Inc. | Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets |
US5798083A (en) | 1988-11-03 | 1998-08-25 | Igen International, Inc. | Apparatus for improved luminescence assays using particle concentration and chemiluminescence detection |
US5110693A (en) | 1989-09-28 | 1992-05-05 | Hyperion Catalysis International | Electrochemical cell |
US5324457A (en) | 1989-10-02 | 1994-06-28 | Board Of Regents, The University Of Tx System | Devices and methods for generating electrogenerated chemiluminescence |
US5527670A (en) | 1990-09-12 | 1996-06-18 | Scientific Generics Limited | Electrochemical denaturation of double-stranded nucleic acid |
US5776672A (en) | 1990-09-28 | 1998-07-07 | Kabushiki Kaisha Toshiba | Gene detection method |
IT1252041B (en) | 1990-10-11 | 1995-05-29 | Enimont Anic Srl | SOLID COMPONENT OF CATALYST FOR THE (CO) POLYMERIZATION OF ETHYLENE |
JPH0534345A (en) | 1991-02-19 | 1993-02-09 | Tdk Corp | Measuring method of antigen-antibody utilizing chemiluminescence |
AU1770492A (en) * | 1991-04-01 | 1992-11-02 | Brigham And Women's Hospital | Microassay system and neutrophil derived secretagogue |
DE4123817C2 (en) * | 1991-07-18 | 1994-06-09 | Berthold Lab Prof Dr | Radiation measuring device, in particular for measuring luminescence |
US5187096A (en) | 1991-08-08 | 1993-02-16 | Rensselaer Polytechnic Institute | Cell substrate electrical impedance sensor with multiple electrode array |
US5639603A (en) | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
US5264103A (en) * | 1991-10-18 | 1993-11-23 | Matsushita Electric Industrial Co., Ltd. | Biosensor and a method for measuring a concentration of a substrate in a sample |
US5204615A (en) * | 1991-10-24 | 1993-04-20 | Interconnect Devices, Inc. | Module attachment for printed circuit board test fixtures |
US5632957A (en) * | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
US6051380A (en) * | 1993-11-01 | 2000-04-18 | Nanogen, Inc. | Methods and procedures for molecular biological analysis and diagnostics |
US5849486A (en) | 1993-11-01 | 1998-12-15 | Nanogen, Inc. | Methods for hybridization analysis utilizing electrically controlled hybridization |
IL103674A0 (en) * | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
US5370842A (en) * | 1991-11-29 | 1994-12-06 | Canon Kabushiki Kaisha | Sample measuring device and sample measuring system |
ZA929351B (en) | 1991-12-11 | 1993-06-04 | Igen Inc | Electrochemiluminescent label for DNA assays. |
US5314804A (en) * | 1992-03-24 | 1994-05-24 | Serim Research Corporation | Test for Helicobacter pylori |
US5384031A (en) | 1992-04-29 | 1995-01-24 | Diametrics Medical, Inc. | Reference electrode |
US5541061A (en) | 1992-04-29 | 1996-07-30 | Affymax Technologies N.V. | Methods for screening factorial chemical libraries |
US5565325A (en) | 1992-10-30 | 1996-10-15 | Bristol-Myers Squibb Company | Iterative methods for screening peptide libraries |
US5389215A (en) * | 1992-11-05 | 1995-02-14 | Nippon Telegraph And Telephone Corporation | Electrochemical detection method and apparatus therefor |
WO1994012885A1 (en) * | 1992-11-20 | 1994-06-09 | Dainabot Co., Ltd. | Multi-channel automatic immunoassay system |
US5547555A (en) * | 1993-02-22 | 1996-08-20 | Ohmicron Technology, Inc. | Electrochemical sensor cartridge |
AU6268994A (en) | 1993-02-25 | 1994-09-14 | Diametrics Medical, Inc. | Disposable electrochemical measurement cartridge |
DE69431334T2 (en) * | 1993-11-12 | 2003-09-18 | Inverness Medical Switzerland | Device for reading test strips |
DE59509994D1 (en) * | 1994-06-03 | 2002-02-21 | Metrohm Ag Herisau | Device for voltammetry, indicator electrode arrangement for such a device, in particular as part of a tape cassette, and row analysis method for voltammetry |
US5429735A (en) * | 1994-06-27 | 1995-07-04 | Miles Inc. | Method of making and amperometric electrodes |
US5786141A (en) | 1994-08-26 | 1998-07-28 | Bard; Allen J. | Electrogenerated chemiluminescence labels for analysis and/or referencing |
US5648213A (en) | 1994-08-30 | 1997-07-15 | Beckman Instruments, Inc. | Compositions and methods for use in detection of analytes |
US5463564A (en) | 1994-09-16 | 1995-10-31 | 3-Dimensional Pharmaceuticals, Inc. | System and method of automatically generating chemical compounds with desired properties |
GB9419513D0 (en) * | 1994-09-28 | 1994-11-16 | Enviromed Plc | Electrochemical oxygen sensor |
US5527710A (en) | 1994-12-02 | 1996-06-18 | Igen, Inc. | Rate measurements of biomolecular reactions using electrochemiluminescence |
US5866434A (en) | 1994-12-08 | 1999-02-02 | Meso Scale Technology | Graphitic nanotubes in luminescence assays |
US5641623A (en) | 1995-01-04 | 1997-06-24 | Martin; Mark T. | Electrochemiluminescence assay |
US5643713A (en) | 1995-06-07 | 1997-07-01 | Liang; Pam | Electrochemiluminescent monitoring of compounds |
HUP9801679A3 (en) * | 1995-03-10 | 2001-01-29 | Meso Scale Technologies Llc Co | Process and agent for multi-array, multi-specific electrochemiluminescence testing |
US6207369B1 (en) | 1995-03-10 | 2001-03-27 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
US6140045A (en) | 1995-03-10 | 2000-10-31 | Meso Scale Technologies | Multi-array, multi-specific electrochemiluminescence testing |
US6340588B1 (en) * | 1995-04-25 | 2002-01-22 | Discovery Partners International, Inc. | Matrices with memories |
US5679519A (en) | 1995-05-09 | 1997-10-21 | Oprandy; John J. | Multi-label complex for enhanced sensitivity in electrochemiluminescence assay |
US6319670B1 (en) | 1995-05-09 | 2001-11-20 | Meso Scale Technology Llp | Methods and apparatus for improved luminescence assays using microparticles |
US5593135A (en) | 1995-05-12 | 1997-01-14 | Asahi/America, Inc. | Precise throttling ball valve |
US5589136A (en) | 1995-06-20 | 1996-12-31 | Regents Of The University Of California | Silicon-based sleeve devices for chemical reactions |
US6127127A (en) | 1995-06-27 | 2000-10-03 | The University Of North Carolina At Chapel Hill | Monolayer and electrode for detecting a label-bearing target and method of use thereof |
US5968745A (en) * | 1995-06-27 | 1999-10-19 | The University Of North Carolina At Chapel Hill | Polymer-electrodes for detecting nucleic acid hybridization and method of use thereof |
US5569588A (en) | 1995-08-09 | 1996-10-29 | The Regents Of The University Of California | Methods for drug screening |
US5884939A (en) * | 1995-09-22 | 1999-03-23 | Toyo Tire & Rubber Co., Ltd. | Air bag system for automotive passenger seat |
DE19610354C1 (en) | 1996-03-15 | 1997-11-20 | Innova Gmbh | Device, method and device for isolating nucleic acids |
GB9606850D0 (en) | 1996-04-01 | 1996-06-05 | Univ Liverpool | An assay system and novel labelled compounds for use therwith |
US5783431A (en) | 1996-04-24 | 1998-07-21 | Chromaxome Corporation | Methods for generating and screening novel metabolic pathways |
US6001307A (en) * | 1996-04-26 | 1999-12-14 | Kyoto Daiichi Kagaku Co., Ltd. | Device for analyzing a sample |
DE19646505A1 (en) * | 1996-11-12 | 1998-05-14 | Itt Ind Gmbh Deutsche | Device for carrying out tests on cell samples and the like |
US6215593B1 (en) * | 1996-11-13 | 2001-04-10 | Ian A. Bruce | Portable wide-field optical system with microlenses and fiber-optic image transfer element |
AU741076B2 (en) * | 1996-12-12 | 2001-11-22 | Prolume, Ltd. | Apparatus and method for detecting and identifying infectious agents |
JP4663824B2 (en) | 1996-12-31 | 2011-04-06 | ハイ スループット ジェノミクス インコーポレイテッド | Multiplexed molecular analyzer and method |
US5972694A (en) | 1997-02-11 | 1999-10-26 | Mathus; Gregory | Multi-well plate |
FI970593A (en) | 1997-02-12 | 1998-08-13 | Sakari Mikael Kulmala | Use of coated conductors for analytical purposes |
EP0978722B1 (en) * | 1997-04-24 | 2002-10-16 | Daikin Industries, Ltd. | comb-shaped sensor element with electrodes on the projections and edge connector at the opposing edge |
US5759364A (en) * | 1997-05-02 | 1998-06-02 | Bayer Corporation | Electrochemical biosensor |
US5981268A (en) * | 1997-05-30 | 1999-11-09 | Board Of Trustees, Leland Stanford, Jr. University | Hybrid biosensors |
FR2764381A1 (en) | 1997-06-09 | 1998-12-11 | Univ De Neuchatel | ELECTROCHEMICOLUMINESCENT DETECTOR |
DE19725190A1 (en) | 1997-06-14 | 1998-12-17 | Innova Gmbh | Devices with integrated electrodes made of electrically conductive plastics |
US6258326B1 (en) * | 1997-09-20 | 2001-07-10 | Ljl Biosystems, Inc. | Sample holders with reference fiducials |
US6413783B1 (en) | 1997-09-18 | 2002-07-02 | Meso Scale Technologies, Llc | Assay sonication apparatus and methodology |
US6486947B2 (en) * | 1998-07-22 | 2002-11-26 | Ljl Biosystems, Inc. | Devices and methods for sample analysis |
US6238869B1 (en) | 1997-12-19 | 2001-05-29 | High Throughput Genomics, Inc. | High throughput assay system |
US7297312B2 (en) * | 1998-03-16 | 2007-11-20 | University Of Cincinnati | Simultaneous multianalyte electrochemical assay based on spatial resolution |
US6200531B1 (en) | 1998-05-11 | 2001-03-13 | Igen International, Inc. | Apparatus for carrying out electrochemiluminescence test measurements |
EP0962773A1 (en) | 1998-06-03 | 1999-12-08 | Mark Howard Jones | Electrochemical based assay processes instrument and labels |
US6251595B1 (en) * | 1998-06-18 | 2001-06-26 | Agilent Technologies, Inc. | Methods and devices for carrying out chemical reactions |
GB9815042D0 (en) | 1998-07-10 | 1998-09-09 | Imperial College | Detector |
FR2781886B1 (en) * | 1998-07-31 | 2001-02-16 | Commissariat Energie Atomique | MULTIPLE POINT CHEMICAL OR BIOLOGICAL ANALYSIS MICROSYSTEM |
US6214552B1 (en) | 1998-09-17 | 2001-04-10 | Igen International, Inc. | Assays for measuring nucleic acid damaging activities |
US6312896B1 (en) * | 1998-09-17 | 2001-11-06 | Igen Inaternational, Inc. | Assays for measuring nucleic acid binding proteins and enzyme activities |
AT410718B (en) * | 1998-10-28 | 2003-07-25 | Schindler Hansgeorg Dr | DEVICE FOR VISUALIZING MOLECULES |
US6438497B1 (en) * | 1998-12-11 | 2002-08-20 | Symyx Technologies | Method for conducting sensor array-based rapid materials characterization |
US6251685B1 (en) * | 1999-02-18 | 2001-06-26 | Agilent Technologies, Inc. | Readout method for molecular biological electronically addressable arrays |
EP1185363B1 (en) * | 1999-03-11 | 2005-06-15 | Combimatrix Corporation | Self assembling arrays |
US6352838B1 (en) * | 1999-04-07 | 2002-03-05 | The Regents Of The Universtiy Of California | Microfluidic DNA sample preparation method and device |
US6136268A (en) | 1999-08-17 | 2000-10-24 | Orion Diagnostica | Method for luminescence measurements |
US6219674B1 (en) | 1999-11-24 | 2001-04-17 | Classen Immunotherapies, Inc. | System for creating and managing proprietary product data |
JP3636068B2 (en) * | 2000-02-16 | 2005-04-06 | 日産自動車株式会社 | Fuel cell control device |
JP4700819B2 (en) * | 2000-03-10 | 2011-06-15 | キヤノン株式会社 | Substrate holding apparatus, semiconductor manufacturing apparatus, and semiconductor device manufacturing method |
DE10013254A1 (en) * | 2000-03-17 | 2001-10-04 | Friz Biochem Gmbh | New apparatus, useful for detecting biomolecules and polymers, comprises array of samples containing specific molecules with separate light sources and system for detecting which samples interact with molecule to be detected |
DE10016408C2 (en) * | 2000-04-01 | 2002-11-14 | Hinterkopf Gmbh | Machine for printing or other decorating hollow bodies |
US7527821B2 (en) | 2000-05-02 | 2009-05-05 | Smiths Detection Inc. | Sensor fabricating method |
US6468736B2 (en) * | 2000-06-22 | 2002-10-22 | Atto Instruments, Llc. | High efficiency cell analysis system and high throughput drug screening system |
US6686193B2 (en) * | 2000-07-10 | 2004-02-03 | Vertex Pharmaceuticals, Inc. | High throughput method and system for screening candidate compounds for activity against target ion channels |
US6563581B1 (en) * | 2000-07-14 | 2003-05-13 | Applera Corporation | Scanning system and method for scanning a plurality of samples |
US6932893B2 (en) * | 2000-10-02 | 2005-08-23 | Sophion Bioscience A/S | System for electrophysiological measurements |
GB2384309B8 (en) * | 2000-10-13 | 2016-03-02 | Irm Llc | High throughput processing system and method of using |
US7094595B2 (en) * | 2000-10-30 | 2006-08-22 | Sru Biosystems, Inc. | Label-free high-throughput optical technique for detecting biomolecular interactions |
US6692700B2 (en) * | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
WO2002075276A2 (en) * | 2001-03-15 | 2002-09-26 | The Regents Of The University Of California | Positioning of organic and inorganic objects by electrophoretic forces including for microlens alignment |
DK2420824T3 (en) | 2001-06-29 | 2019-03-25 | Meso Scale Technologies Llc | Multi-well plate with an array of wells and kit for use in performing an ECL assay |
-
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