CA2453430A1 - Optical sensor containing particles for in situ measurement of analytes - Google Patents

Optical sensor containing particles for in situ measurement of analytes Download PDF

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Publication number
CA2453430A1
CA2453430A1 CA002453430A CA2453430A CA2453430A1 CA 2453430 A1 CA2453430 A1 CA 2453430A1 CA 002453430 A CA002453430 A CA 002453430A CA 2453430 A CA2453430 A CA 2453430A CA 2453430 A1 CA2453430 A1 CA 2453430A1
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CA
Canada
Prior art keywords
sensor
analyte
particles
chromophore
macrophages
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002453430A
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French (fr)
Other versions
CA2453430C (en
Inventor
Bo Petersson
Jesper Kristensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Minimed Inc
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2453430A1 publication Critical patent/CA2453430A1/en
Application granted granted Critical
Publication of CA2453430C publication Critical patent/CA2453430C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
    • A61B5/14735—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter comprising an immobilised reagent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/415—Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/417—Evaluating particular organs or parts of the immune or lymphatic systems the bone marrow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/418—Evaluating particular organs or parts of the immune or lymphatic systems lymph vessels, ducts or nodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Abstract

The invention relates to a sensor for the in vivo measurement of an analyte, comprising a plurality of particles of suitable size such that when implante d in the body of a mammal the particles can be ingested by macrophages and transported away from the site of implantation, each particle containing the components of an assay having a readout which is an optical signal detectabl e transdermally by external optical means, and either each particles being contained within a biodegradable material preventing ingestion by the macrophages, or each particle being non-biodegradable. The invention relates to a process for the detection of an analyte using such a sensor, comprising implantation of the sensor into the skin of a mammal, transdermal detection of analyte using external optical means, degradation of the biodegradable material, ingestion of the particles by macrophages, and removal of the particles from the site of implantation by macrophages.

Claims (11)

1. A sensor for the in vivo measurement of an analyte, comprising a plurality of particles of suitable size such that when implanted in the body of a mammal the particles can be ingested by macrophages and transported away from the site of implantation, each particle containing the components of an assay having a readout which is an optical signal detectable or measurable transdermally by external optical means, and either each particle being contained within a biodegradable material preventing ingestion by the macrophages, or each particle being non-biodegradable.
2. A sensor as claimed in Claim 1, wherein the particles are less than 5 µm in their largest dimension.
3. A sensor as claimed in either one of Claims 1 or 2, wherein the biodegradable material is present and is a gel.
4. A sensor as claimed in any one of the preceding claims, wherein the assay is a binding assay.
5. A sensor as claimed in Claim 4, wherein the binding assay is a competitive binding assay, the components of which include an analyte binding agent and an analyte analogue.
6. A sensor as claimed in Claim 5, wherein the analyte analogue is labelled with a first chromophore and the analyte binding agent is labelled with a second chromophore, the emission spectrum of the first chromophore or second chromophore overlapping with the absorption spectrum of the second chromophore or first chromophore respectively.
7. A sensor as claimed in either one of Claims 5 or 6, wherein the binding agent is an antibody, a Fab fragment, a lectin, a hormone receptor, a drug receptor, an aptamer or a molecularly-imprinted polymer.
8. A sensor as claimed in any one of the preceding claims, wherein the detectable or measurable optical signal is generated by fluorescence resonance energy transfer, fluorescence polarisation, fluorescence quenching, phosphorescence, luminescence enhancement, luminescence quenching, diffraction or plasmon resonance.
9. A sensor as claimed in any one of the preceding claims, wherein the particles are non-biodegradable.
10. A sensor as claimed in any one of the preceding claims, wherein the analyte is glucose.
11. A process for the detection of an analyte using a sensor as claimed in any one of the preceding claims, comprising implantation of the sensor into the skin of a mammmal, transdermal detection or measurement of analyte using external optical means, degradation of the biodegradable material, ingestion of the particles by macrophages, and removal of the particles from the site of implantation by macrophages.
CA2453430A 2001-07-10 2002-06-27 Optical sensor containing particles for in situ measurement of analytes Expired - Fee Related CA2453430C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0116853.3A GB0116853D0 (en) 2001-07-10 2001-07-10 Optical sensor containing particles for in SITU measurement of analytes
GB0116853.3 2001-07-10
PCT/EP2002/007108 WO2003006992A1 (en) 2001-07-10 2002-06-27 Optical sensor containing particles for in situ measurement of analytes

Publications (2)

Publication Number Publication Date
CA2453430A1 true CA2453430A1 (en) 2003-01-23
CA2453430C CA2453430C (en) 2010-11-09

Family

ID=9918250

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2453430A Expired - Fee Related CA2453430C (en) 2001-07-10 2002-06-27 Optical sensor containing particles for in situ measurement of analytes

Country Status (12)

Country Link
US (1) US7228159B2 (en)
EP (1) EP1405075B1 (en)
JP (1) JP4280629B2 (en)
AT (1) ATE420356T1 (en)
CA (1) CA2453430C (en)
DE (1) DE60230758D1 (en)
DK (1) DK1405075T3 (en)
ES (1) ES2316606T3 (en)
GB (1) GB0116853D0 (en)
NO (1) NO332247B1 (en)
NZ (1) NZ530928A (en)
WO (1) WO2003006992A1 (en)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6036924A (en) 1997-12-04 2000-03-14 Hewlett-Packard Company Cassette of lancet cartridges for sampling blood
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
WO2002100460A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Electric lancet actuator
EP1404232B1 (en) 2001-06-12 2009-12-02 Pelikan Technologies Inc. Blood sampling apparatus and method
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
US7316700B2 (en) 2001-06-12 2008-01-08 Pelikan Technologies, Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
ES2357887T3 (en) 2001-06-12 2011-05-03 Pelikan Technologies Inc. APPARATUS FOR IMPROVING THE BLOOD OBTAINING SUCCESS RATE FROM A CAPILLARY PUNCTURE.
AU2002348683A1 (en) 2001-06-12 2002-12-23 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US7371247B2 (en) 2002-04-19 2008-05-13 Pelikan Technologies, Inc Method and apparatus for penetrating tissue
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7717863B2 (en) 2002-04-19 2010-05-18 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7175642B2 (en) 2002-04-19 2007-02-13 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7648468B2 (en) 2002-04-19 2010-01-19 Pelikon Technologies, Inc. Method and apparatus for penetrating tissue
US7708701B2 (en) 2002-04-19 2010-05-04 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US7291117B2 (en) 2002-04-19 2007-11-06 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US20040082080A1 (en) 2002-08-01 2004-04-29 Wolf David E. Method of measuring molecular interactions
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
ES2347248T3 (en) 2003-05-30 2010-10-27 Pelikan Technologies Inc. PROCEDURE AND APPLIANCE FOR FLUID INJECTION.
US7850621B2 (en) 2003-06-06 2010-12-14 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
WO2005033659A2 (en) 2003-09-29 2005-04-14 Pelikan Technologies, Inc. Method and apparatus for an improved sample capture device
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
US8668656B2 (en) 2003-12-31 2014-03-11 Sanofi-Aventis Deutschland Gmbh Method and apparatus for improving fluidic flow and sample capture
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
GB0411162D0 (en) * 2004-05-19 2004-06-23 Precisense As Optical sensor for in vivo detection of analyte
US8828203B2 (en) 2004-05-20 2014-09-09 Sanofi-Aventis Deutschland Gmbh Printable hydrogels for biosensors
EP1765194A4 (en) 2004-06-03 2010-09-29 Pelikan Technologies Inc Method and apparatus for a fluid sampling device
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
GB0426823D0 (en) 2004-12-07 2005-01-12 Precisense As Sensor for detection of glucose
GB0426822D0 (en) 2004-12-07 2005-01-12 Precisense As Sensor for detection of glucose
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
JP5033810B2 (en) * 2005-12-07 2012-09-26 プレシセンス・エー／エス Sensor having polymer having flexible carbohydrate and method for synthesizing polymer therefor
US8126554B2 (en) 2006-05-17 2012-02-28 Cardiac Pacemakers, Inc. Implantable medical device with chemical sensor and related methods
DE102007024642A1 (en) * 2007-05-24 2008-11-27 Eyesense Ag Hydrogel implant for sensor of metabolites on the eye
US9386944B2 (en) 2008-04-11 2016-07-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte detecting device
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
CA2716502C (en) 2009-05-15 2015-06-16 Interface Biologics, Inc. Antithrombogenic hollow fiber membranes and filters
US9517023B2 (en) 2009-06-01 2016-12-13 Profusa, Inc. Method and system for directing a localized biological response to an implant
US8554174B2 (en) 2009-06-15 2013-10-08 Alcatel Lucent Selective first delivery attempt (FDA) processing for text messages
US8795595B2 (en) 2010-04-07 2014-08-05 Medtronic Minimed, Inc. Sensor substrate systems and methods
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US10010272B2 (en) 2010-05-27 2018-07-03 Profusa, Inc. Tissue-integrating electronic apparatus
EP2624744A4 (en) * 2010-10-06 2017-03-29 Profusa, Inc. Tissue-integrating sensors
US9642568B2 (en) 2011-09-06 2017-05-09 Medtronic Minimed, Inc. Orthogonally redundant sensor systems and methods
US8999720B2 (en) 2011-11-17 2015-04-07 Medtronic Minimed, Inc. Aqueous radiation protecting formulations and methods for making and using them
EP2967454B1 (en) 2013-03-14 2020-04-22 Profusa, Inc. Method and device for correcting optical signals
WO2014196169A1 (en) * 2013-06-04 2014-12-11 パナソニック株式会社 Sensor chip, detection method and detection device
EP3777656A1 (en) 2013-06-06 2021-02-17 Profusa, Inc. Apparatus for detecting optical signals from implanted sensors
US9936905B2 (en) 2013-10-25 2018-04-10 Medtronic Minimed, Inc. Sensor with optical interface
WO2016054079A1 (en) 2014-09-29 2016-04-07 Zyomed Corp. Systems and methods for blood glucose and other analyte detection and measurement using collision computing
CN106999118B (en) * 2014-10-13 2020-07-17 葡萄糖传感器公司 Analyte sensing device
US9337040B1 (en) 2014-12-05 2016-05-10 Varian Semiconductor Equipment Associates, Inc. Angled ion beam processing of heterogeneous structure
KR102410471B1 (en) * 2015-05-11 2022-06-17 삼성전자주식회사 Needle for biosensor and bio sensor including the same
US20160354500A1 (en) 2015-06-02 2016-12-08 Medtronic Minimed, Inc. Protective agents against e-beam irradiation for proteins in optical sensing chemistry
US10716500B2 (en) 2015-06-29 2020-07-21 Cardiac Pacemakers, Inc. Systems and methods for normalization of chemical sensor data based on fluid state changes
US9554738B1 (en) 2016-03-30 2017-01-31 Zyomed Corp. Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing
US20170290535A1 (en) 2016-04-08 2017-10-12 Medtronic Minimed, Inc. Analyte sensor with indicators
WO2017195035A1 (en) * 2016-05-10 2017-11-16 Interface Biologics, Inc. Implantable glucose sensors having a biostable surface
EP3529300A4 (en) 2016-10-18 2020-03-18 Evonik Canada Inc. Plasticized pvc admixtures with surface modifying macromolecules and articles made therefrom
WO2018119400A1 (en) 2016-12-22 2018-06-28 Profusa, Inc. System and single-channel luminescent sensor for and method of determining analyte value
US10463285B2 (en) * 2017-04-03 2019-11-05 Medtronic, Inc. Hermetically-sealed package and method of forming same
US10543288B2 (en) 2017-04-28 2020-01-28 Medtronic Minimed, Inc. Modified-dextrans for use in optical glucose assays
US10792378B2 (en) 2017-04-28 2020-10-06 Medtronics Minimed, Inc. Using a blue-shifted reference dye in an optical glucose assay
CN108968976B (en) 2017-05-31 2022-09-13 心脏起搏器股份公司 Implantable medical device with chemical sensor
CN109381195B (en) 2017-08-10 2023-01-10 心脏起搏器股份公司 Systems and methods including electrolyte sensor fusion
CN109419515B (en) 2017-08-23 2023-03-24 心脏起搏器股份公司 Implantable chemical sensor with staged activation
CN109864746B (en) 2017-12-01 2023-09-29 心脏起搏器股份公司 Multimode analyte sensor for medical devices
CN109864747B (en) 2017-12-05 2023-08-25 心脏起搏器股份公司 Multimode analyte sensor optoelectronic interface
US20210228128A1 (en) * 2018-05-08 2021-07-29 Abbott Diabetes Care Inc. Sensing systems and methods for identifying emotional stress events
TWM599631U (en) * 2019-08-02 2020-08-11 華廣生技股份有限公司 Physiological signal sensing device
WO2023137339A1 (en) * 2022-01-11 2023-07-20 Basf Se Screening the degradation of polymer microparticles on a chip

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4344438A (en) * 1978-08-02 1982-08-17 The United States Of America As Represented By The Department Of Health, Education And Welfare Optical sensor of plasma constituents
US5342789A (en) * 1989-12-14 1994-08-30 Sensor Technologies, Inc. Method and device for detecting and quantifying glucose in body fluids
US5628310A (en) * 1995-05-19 1997-05-13 Joseph R. Lakowicz Method and apparatus to perform trans-cutaneous analyte monitoring
WO1997019188A1 (en) 1995-11-22 1997-05-29 Minimed, Inc. Detection of biological molecules using chemical amplification and optical sensors
US6002817A (en) * 1997-09-29 1999-12-14 The Regents Of The University Of Michigan Optical sensors for the detection of nitric oxide
GB9814506D0 (en) * 1998-07-03 1998-09-02 Stanley Christopher J Optical sensor for insitu measurement of analytes
JP4812167B2 (en) 1999-02-12 2011-11-09 モレキュラー インサイト ファーマスーティカルズ インコーポレイテッド Drug transport matrix and methods for making and using the same
US6366793B1 (en) * 1999-09-10 2002-04-02 Beckman Coulter, Inc. Minimally invasive methods for measuring analtes in vivo
US6383767B1 (en) * 2000-01-21 2002-05-07 Motorola, Inc. Luminescent in vivo glucose measurement

Also Published As

Publication number Publication date
CA2453430C (en) 2010-11-09
US20040199062A1 (en) 2004-10-07
GB0116853D0 (en) 2001-09-05
ES2316606T3 (en) 2009-04-16
NO332247B1 (en) 2012-08-06
EP1405075B1 (en) 2009-01-07
JP2004534255A (en) 2004-11-11
ATE420356T1 (en) 2009-01-15
DK1405075T3 (en) 2009-04-20
JP4280629B2 (en) 2009-06-17
DE60230758D1 (en) 2009-02-26
NZ530928A (en) 2005-02-25
EP1405075A1 (en) 2004-04-07
US7228159B2 (en) 2007-06-05
NO20040098L (en) 2004-03-09
WO2003006992A1 (en) 2003-01-23

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