CA2457018C - Device based on nitinol, a process for its production and its use - Google Patents
Device based on nitinol, a process for its production and its use Download PDFInfo
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- CA2457018C CA2457018C CA2457018A CA2457018A CA2457018C CA 2457018 C CA2457018 C CA 2457018C CA 2457018 A CA2457018 A CA 2457018A CA 2457018 A CA2457018 A CA 2457018A CA 2457018 C CA2457018 C CA 2457018C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/06—Titanium or titanium alloys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/3154—Of fluorinated addition polymer from unsaturated monomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31678—Of metal
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31725—Of polyamide
Abstract
The present invention relates to a device comprising a substrate based essentially on nitinol and, arranged thereon at least partially, a covering or a coating based on at least one polyphosphazene derivative having the general formula (I), a process for its production, and the use of the device as an artificial implant, vascular or nonvascular stent, catheter, thrombolectomy or embolectomy catheter, fragmentation spindle or catheter, filter, vascular connector, hernia patch, oral, dental or throat implant or urether.
Description
Device based on nitinol, a process for its production, and its use The present invention relates to a device, comprising a substrate based essentially on nitinol and, arranged thereon at least partially, a covering or a coating based on at least one polyphosphazene derivative having the general formula (I), a process for its production, and the use of the device as an artificial implant, vascular or nonvascular stmt, catheter, thrombolectomy or embolectomy catheter, fragmentation spindle or catheter, guide wire, filter, vascular connector, hernia patch, oral, dental or throat implant or v urether.
The material nitinol is an intermetallic compound, mainly consisting of the metals nickel and titanium.
After earlier deformation at a low temperature, nitinol has the peculiarity of assuming its original shape again after heating to a high temperature. This property is also known as "thermal shape memory".
Moreover, nitinol has a second functional property, the "mechanical shape memory" or alternatively super-elasticity. The latter property in particular, the ability to tolerate elastic extensions up to 8%
completely reversibly, has led to a large number of applications as implants and components for interventional treatment methods, such as, for example, stem s, stmt grafts, vascular connectors, filters, capture baskets and guide wires. Using insertion instruments, stems and filters are customarily brought to the position of the vessel at which they open up to the original shape. For insertion into the insertion system, the nitinol component is compressed in the cold at extensions up to approximately 8%. For instance, endovascular stems having a defined diameter are first processed, then compressed in the cold and brought to the position of the vessel at which they are to be placed by means of insertion instruments. At the
The material nitinol is an intermetallic compound, mainly consisting of the metals nickel and titanium.
After earlier deformation at a low temperature, nitinol has the peculiarity of assuming its original shape again after heating to a high temperature. This property is also known as "thermal shape memory".
Moreover, nitinol has a second functional property, the "mechanical shape memory" or alternatively super-elasticity. The latter property in particular, the ability to tolerate elastic extensions up to 8%
completely reversibly, has led to a large number of applications as implants and components for interventional treatment methods, such as, for example, stem s, stmt grafts, vascular connectors, filters, capture baskets and guide wires. Using insertion instruments, stems and filters are customarily brought to the position of the vessel at which they open up to the original shape. For insertion into the insertion system, the nitinol component is compressed in the cold at extensions up to approximately 8%. For instance, endovascular stems having a defined diameter are first processed, then compressed in the cold and brought to the position of the vessel at which they are to be placed by means of insertion instruments. At the
- 2 -desired position, the previously compressed stmt opens up to its original shape due to the body heat and/or due to its elastic ability and supports the surrounding vessel. Owing to the shape which is already fixed during manufacture, an overextension of the vessel can be avoided.
The material nitinol per se has a very good body compatibility. In order to avoid from the start a "bleeding out" of r~ickel or nickel ions possibly occurring and in order to achieve a particularly uniform surface structure, various techniques were developed in order to seal the surface of an implant essentially manufactured from nitinol, such as, for example, a stmt, and to provide it with a leakproof, nickel-impermeable layer. These processes of chemical aftertreatment customarily lead to a leakproof layer of titanium dioxide, through which nickel can hardly escape. These processes are known, inter alia, as electropolishing and are customary in different variants.
Although oxidic layers do not inevitably worsen the physical compatibility of implants, they yield a surface which only allows a low hemocompatibility to be expected and thus makes necessary the use of vitamin K
antagonists, and other anticoagulants, such as acetyl-salicylic acid. This represents an additional stress for the affected patients.
Moreover, the process of electrochemical polishing cannot be employed everywhere. In areas or places in which electrochemical polishing cannot be used, such as, for example, in implants which consist of a combination of various materials and accordingly would dissolve these selectively during electrochemical polishing, natural oxide layers offer a poorer protection against the discharge of metal ions and accordingly a lower blood and physical compatibility.
The material nitinol per se has a very good body compatibility. In order to avoid from the start a "bleeding out" of r~ickel or nickel ions possibly occurring and in order to achieve a particularly uniform surface structure, various techniques were developed in order to seal the surface of an implant essentially manufactured from nitinol, such as, for example, a stmt, and to provide it with a leakproof, nickel-impermeable layer. These processes of chemical aftertreatment customarily lead to a leakproof layer of titanium dioxide, through which nickel can hardly escape. These processes are known, inter alia, as electropolishing and are customary in different variants.
Although oxidic layers do not inevitably worsen the physical compatibility of implants, they yield a surface which only allows a low hemocompatibility to be expected and thus makes necessary the use of vitamin K
antagonists, and other anticoagulants, such as acetyl-salicylic acid. This represents an additional stress for the affected patients.
Moreover, the process of electrochemical polishing cannot be employed everywhere. In areas or places in which electrochemical polishing cannot be used, such as, for example, in implants which consist of a combination of various materials and accordingly would dissolve these selectively during electrochemical polishing, natural oxide layers offer a poorer protection against the discharge of metal ions and accordingly a lower blood and physical compatibility.
- 3 -A form of surface improvement to be additionally used would thus be desirable, such as, for example, a coating which makes leakproof the properties of a surface which is produced by electropolishing or in another way and is impermeable to metal ions, in particular nickel ions, with respect to the hemo- and biocompatibility and also further improves other properties, such as, in particular, the glidability, without damaging the leakproofness and isolating properties of such a surface.
From the prior art, an abundance of materials are known and investigated which are used for the production of such coatings. For instance, an expandable sheath of E-PTFE is disclosed in WO 98/56312, which can be used for the culturing of artificial vessels. Other materials for this use are cited in EP-A-0-810 845, in which, for example, polymers are mentioned which are described in US-A-4,883,699 and US-A-4,911,691. Further polymers for the purpose mentioned are, for example, hydrolyzed polyacrylonitrile (US-A-4,480,642), hydro-philic polyethers (US-A-4,798,876) and polyurethane diacrylates (US-A-4,424,395). Furthermore, various hydrogels are known which can be employed as a coating for this purpose. The number of the potentially usable materials can be supplemented further by polyvinyl-pyrrolidone (PVP), polyvinyl alcohols (PVA), poly-ethylene oxide (PEO) and polyhydroxyethyl methacrylate p(HEMA). The use of a number of standard materials such as polyurethanes, polyethylenes and polypropylenes as possible materials is further described in the prior art. Likewise, mixtures of these materials with one another are known for the coating of implants. A number of further materials is moreover disclosed in EP-A-0-804 909.
The properties of these materials are different and it can be assumed therefrom that each of these materials
From the prior art, an abundance of materials are known and investigated which are used for the production of such coatings. For instance, an expandable sheath of E-PTFE is disclosed in WO 98/56312, which can be used for the culturing of artificial vessels. Other materials for this use are cited in EP-A-0-810 845, in which, for example, polymers are mentioned which are described in US-A-4,883,699 and US-A-4,911,691. Further polymers for the purpose mentioned are, for example, hydrolyzed polyacrylonitrile (US-A-4,480,642), hydro-philic polyethers (US-A-4,798,876) and polyurethane diacrylates (US-A-4,424,395). Furthermore, various hydrogels are known which can be employed as a coating for this purpose. The number of the potentially usable materials can be supplemented further by polyvinyl-pyrrolidone (PVP), polyvinyl alcohols (PVA), poly-ethylene oxide (PEO) and polyhydroxyethyl methacrylate p(HEMA). The use of a number of standard materials such as polyurethanes, polyethylenes and polypropylenes as possible materials is further described in the prior art. Likewise, mixtures of these materials with one another are known for the coating of implants. A number of further materials is moreover disclosed in EP-A-0-804 909.
The properties of these materials are different and it can be assumed therefrom that each of these materials
- 4 -has particular properties for certain applications 1n the coating of artificial implants and other medical devices. For instance, PVA is very readily soluble in liquids and is rapidly absorbed. Other materials have good blood compatibility. In turn, other materials are particularly readily stretchable. However, all materials exhibit disadvantages in certain areas. PVA, for example, does not show good blood compatibility.
e-PTFE is very readily stretchable, for example, and also exhibits good blood compatibility, but this material is extremely difficult to handle and the production of such coatings necessitates a number of processing steps (cf. WO 96/00103). A surface obtained in such a way is also only temperature-stable within limits and becomes brittle in the cold, which in the specific case of the coating of nitinol leads at least to hairline cracks, at which thrombi can form.
Moreover, the adhesion of such a coating is not particularly good. This becomes brittle during the cold treatment which is necessary and as a result of this detaches very easily, which in particular in the case of implants in endovascular systems can have considerable health sequelae. In the case of other materials, elastic properties which are important in virtually all cases for a coating of the type mentioned are only achieved by the addition of plasticizers.
Plasticizers, however, decrease the blood and physical compatibility considerably. Further, a mobilization of the plasticizers can additionally lead to inflammatory reactions, reactions of the immune and anticoagulation system and thus to stress for the patients.
Fundamentally, howe~ter, the majority of plastics and plastic mixtures "plasticized" in such a way become brittle in the cold and and lose their elasticity. As a result, in the case of such materials the danger is always present that on renewed expansion cracks form or the layer detaches.
e-PTFE is very readily stretchable, for example, and also exhibits good blood compatibility, but this material is extremely difficult to handle and the production of such coatings necessitates a number of processing steps (cf. WO 96/00103). A surface obtained in such a way is also only temperature-stable within limits and becomes brittle in the cold, which in the specific case of the coating of nitinol leads at least to hairline cracks, at which thrombi can form.
Moreover, the adhesion of such a coating is not particularly good. This becomes brittle during the cold treatment which is necessary and as a result of this detaches very easily, which in particular in the case of implants in endovascular systems can have considerable health sequelae. In the case of other materials, elastic properties which are important in virtually all cases for a coating of the type mentioned are only achieved by the addition of plasticizers.
Plasticizers, however, decrease the blood and physical compatibility considerably. Further, a mobilization of the plasticizers can additionally lead to inflammatory reactions, reactions of the immune and anticoagulation system and thus to stress for the patients.
Fundamentally, howe~ter, the majority of plastics and plastic mixtures "plasticized" in such a way become brittle in the cold and and lose their elasticity. As a result, in the case of such materials the danger is always present that on renewed expansion cracks form or the layer detaches.
- 5 -Further known complications which can occur in the case of such a coating are connected with those of the degradation of some substances used for the coating and the degradation products resulting here. For instance, it is known that in the dissolution or the absorption and the decomposition of some of the coating substances known from the prior art inflammatory reactions can occur (van der Giessen, Circulation vol. 94, no. 7.
1996). This problem results either due to the in some cases imperfect compatibility of such coatings or else due to reaction to give decomposition products, which result in the decomposition of the substances mentioned. This lies in particular in the fact that the substances can in some cases only be applied in a not very controlled manner and thus are decomposed or degraded at different positions to a differently severe extent.
Further, for the problem-free handling of coated implants of this type the behavior toward bacteria, macrophages and proteins which deposit on the surfaces of the implants and devices plays a central role, since these deposits, in particular, can lead to inflammation and other problems during the growing-in of the implants. In particular, in the production of vascular implants, such as vascular and nonvascular stem s, hernia patches, urethers, filters, vascular connectors, and implants in the oral, dental and throat region, the properties and peculiarities of the materials mentioned are a significant aspect. This is based on the fact that due to temperature effects during the processing of nitinol cracks produced are starting points for increased thrombus formation and other deposits such as proteins, macrophages, etc., which after implantation can become a risk for the patients.
The present invention is thus based on the object of making available a device based on nitinol suitable as an artificial implant, which is to be distinguished by
1996). This problem results either due to the in some cases imperfect compatibility of such coatings or else due to reaction to give decomposition products, which result in the decomposition of the substances mentioned. This lies in particular in the fact that the substances can in some cases only be applied in a not very controlled manner and thus are decomposed or degraded at different positions to a differently severe extent.
Further, for the problem-free handling of coated implants of this type the behavior toward bacteria, macrophages and proteins which deposit on the surfaces of the implants and devices plays a central role, since these deposits, in particular, can lead to inflammation and other problems during the growing-in of the implants. In particular, in the production of vascular implants, such as vascular and nonvascular stem s, hernia patches, urethers, filters, vascular connectors, and implants in the oral, dental and throat region, the properties and peculiarities of the materials mentioned are a significant aspect. This is based on the fact that due to temperature effects during the processing of nitinol cracks produced are starting points for increased thrombus formation and other deposits such as proteins, macrophages, etc., which after implantation can become a risk for the patients.
The present invention is thus based on the object of making available a device based on nitinol suitable as an artificial implant, which is to be distinguished by
- 6 -high physical compatibility and a very good hemo-compatibility. Additionally, a device of this type should withstand the considerable temperature variations and mechanical stresses, such as, for example, elastic extensions of up to approximately 8%, which occur during the processing and use of the material nitinol, without a worsening of the property profile of the device, such as, for example, detachment or crack formation. This should in particular be achieved without the use of a plasticizer, since otherwise the physical compatibility of such an implant would be considerably decreased.
This object is achieved by the embodiments characterized in the claims. In particular, a device is made available comprising a substrate based essentially on nitinol and, arranged thereon at least partially, a covering or a coating based on at least one polymer having the following general formula (I), ~1 ~2 ~3 P-N-P-N-P=N' R4 F~,s Rd in which n is 2 to oo, the radicals Rl to R6 are identical or different and are an alkoxy, alkyl-sulfonyl, dialkylamino or aryloxy radical or a hetero-cycloalkyl or heteroaryl radical having nitrogen as a hetero atom.
A further subject of the present invention is the use of the device according to the invention as an artificial implant, vascular or nonvascular stmt, catheter, thrombolectomy or embolectomy catheter, fragmentation spindle or catheter, filter, vascular connector, hernia patch, oral, dental or throat implant, guide wire or urether, preferably as a _ 7 _ vascular or nonvascular stmt or as an oral, dental or throat implant.
Surprisingly, the device according to the invention exhibits a high physical compatibility and a very good hemocompatibility. Moreover, the device according to the invention shows essentially no adsorption of macrophages or colonization of bacteria. The polyphosphazene having the above formula (I) specifically selected in the context of the present invention for the coating of the substrate based on nitinol withstands in a particularly advantageous manner the in some cases extreme temperature variations and mechanical stresses in the course of the processing of the nitinol substrate without becoming brittle, detaching or tearing. As a result of the specifically selected polyphosphazene having the above formula (I), the surface properties of nitinol are permanently improved, since the specifically selected poly-phosphazene derivative according to the general formula (I) is degraded neither hydrolytically nor enzymatically. Advantageously, the specifically selected polyphosphazene having the above formula (I) is elastic over a very wide temperature range, in particular at temperatures below the freezing point, without the use of plasticizers.
The degree of polymerization of the polymer according to the above formula (I) used for the coating of the nitinol substrate is 2 to oo. A range for the degree of polymerization of from 20 to 200,000, more preferably of from 40 to 100,000, is preferred.
Preferably, at least one of the radicals R1 to R6 in the polymer used is an alkoxy radical which is substituted by at least one fluorine atom.
The alkyl radicals in the alkoxy, alkylsulfonyl and dialkylamino radicals are, for example, straight- or branched-chain alkyl radicals having 1 to 20 carbon atoms, where the alkyl radicals can be substituted, for example, by at least one halogen atom, such as a fluorine atom.
Examples of alkoxy radicals are methoxy, ethoxy, propoxy and butoxy groups, which can preferably be substituted by at least one fluorine atom. The 2,2.,2-trifluoroethoxy group is particularly preferred.
Examples of alkylsulfonyl radicals are methyl-, ethyl-, propyl- and butylsulfonyl groups. Examples of dialkylamino radicals are dimethyl-, diethyl-, dipropyl- and dibutylamino groups.
The aryl radical in the aryloxy radical is, for example, an aryl unit having one or more aromatic ring systems, where the aryl radical can be substituted, for example, by at least one alkyl radical defined above.
Examples of aryloxy radicals are phenoxy and naphthoxy groups and derivatives thereof.
The heterocycloalkyl radical is, for example, a ring systems containing 3 to 7 atoms, where at least one ring atom is a nitrogen atom. The heterocycloalkyl radical can be substituted, for example, by at least one alkyl radical defined above. Examples of heterocycloalkyl radicals are piperidinyl, piperazinyl, pyrrolidinyl and morpholinyl groups and derivatives thereof. The heteroaryl radical is, for example, a compound having one or more aromatic ring systems, where at least one ring atom is a nitrogen atom. The heteroaryl radical can be substituted, for example, by at least one alkyl radical defined above. Examples of heteroaryl radicals are pyrrolyl, pyridinyl, pyridinolyl, isoquinolyl and quinolyl groups, and derivatives thereof.
In a preferred embodiment of the present invention, the polymer is poly[bis(trifluoroethoxy)phosphazene]. The _ g _ polymer can also be a poly[bis(trifluoroethoxy)-phosphazene] labelled by 3zp, aaP or As or Sb isotopes.
As a volume material, the polymeric compound poly[bis(trifluoroethoxy)phosphazene] shows a good antithrombogenic action (cf. Tur, Investigations on the thrombus resistance of poly[bis(trifluoroethoxy)-phosphazene] and Hollemann Wiberg, "Stickstoff-verbindungen des Phosphors" [Nitrogen compounds of phosphorus], Textbook of inorganic chemistry, 666-669, 91st-100th edition, Walter de Gruyter Verlag, 1985, and Tur, Vinogradova, inter alia "Entwicklungstendenzen bei polymeranalogen Umsetzungen von Polyphosphazen"
[Development tendencies in polymer-analogous reactions of polyphosphazene], Acta Polymerica 39, 424-429, no. 8, 1988. In DE 196 13 048 A1, the fluorinated form of polyphosphazenes was employed as a coating for the coating of artificial implants, heart valves expressly being mentioned. Such implants, however, are not produced from nitinol. Moreover, no disclosure is found in DE 196 13 048 A1 with respect to the aspect of the extreme temperature stresses in nitinol implants.
The devices according to the invention on the one hand have excellent mechanical and body-compatible properties and on the other hand a high resistance against inflammation-promoting organisms, such as, for example, macrophages. As a result of the coating of the nitinol surface with the specifically selected polyphosphazene having the above formula (I), on the one hand the hemo- and biocompatibility of the surface mentioned is improved, on the other hand in the application of the coating or of the covering the surface layer sealing the nitinol surface generated by electropolishing or other techniques is not damaged.
Thus possible subsequent damage after implantation can be reduced.
In the context of the present invention, the substrate based on nitinol can be partially coated with a covering based on at least one polymer having the general formula (I). Customarily, however, it is preferred that the substrate is based on nitinol coated completely with a covering based on at least one polymer having the general formula (I).
In one embodiment of the present invention, the nitinol substrate, which coated thereon has a covering of the polyphosphazene polymer according to the formula (I), is present in the form of an at least partially pierced or perforated tube, such as is customary, for example, in the case of an endovascular implant, such as a stmt .
The covering of at least one polyphosphazene polymer according to the formula (I) according to the present invention arranged or deposited on the nitinol substrate can further comprise one or more pharmaceutically active compounds, such as, for example, cytotoxic compounds, such as rapamycin, taxol, doxorubicin, platinum derivatives, 5-fluoracyl or antiinflammatory active compounds such as diclofenac or acetylsalicylic acid or other active compounds in a corresponding .pharmaceutical preparation, preferably having delayed release or quantitatively controlled release over a relatively long period.
The covering of the device according to the invention has, for example, a thickness of approximately 1 nm to approximately 100 um, preferably to approximately 500 nm and particularly preferably to approximately 100 nm.
In one embodiment of the artificial implant according to the invention, between the surface of the substrate and the covering constructed from the polyphosphazene derivative is arranged a layer which contains an adhesion promoter, i.e. adjacent to the coating based on at least one polymer having the general formula (I) is arranged an adhesion promoter layer.
The adhesion promoter or spacer preferably contains a polar end group. Examples of these are hydroxyl, carboxylate, aldehyde, amino or vitro groups. However, end groups based on an alkoxy, alkylsulfonyl, dialkylamino or aryloxy radical or a heterocycloalkyl or heteroaryl radical having nitrogen as a heteroatom can also be present, where these radicals can also be differently substituted, for example by halogen atoms, in particular fluorine.
In particular, the adhesion promoter can be, for example, an organosilicon compound, preferably an amino-terminated silane or a compound based on an aminosilane, an amino-terminated alkene, a nitro-terminated alkene, a vitro-terminated silane or an alkylphosphonic acid. As adhesion promoter, amino-propyltrimethoxysilane and aminopropyltriethoxysilane are particularly preferred.
The adhesion promoter in particular improves the adhesion of the covering to the surface of the nitinol substrate by coupling of the adhesion promoter to the nitinol surface, for example by means of ionic and/or covalent bonds, and further coupling to the described polymer of the formula (I) of the covering, for example by means of ionic and/or covalent bonds.
A further subject of the present invention relates to the production of the device according to the invention, comprising the steps:
(a) making available of a substrate based on nitinol, (b) exposure of the nitinol surface to a plasma treatment, (c) optionally hydroxylation of the surface treated in step (b) and application of an adhesion promoter and (d) coating of the substrate with at least one polymer of the abovementioned formula (I).
The substrate based on nitinol can be made available in step (a), for example, in the form of an at least partially pierced or perforated tube. The substrate essentially comprises nitinol as the material forming the substrate. The substrate based on nitinol can in the course of this already be subjected to an electropolishing or other treatment for the production of a surface which is leakproof and impermeable to nickel ions.
In step (b) of the process according to the invention, a plasma treatment of the nitinol surface takes place, the plasma preferably being an air or oxygen plasma. By means of the plasma treatment, an ultrathin, leakproof Ti02 layer is produced on the substrate based essentially on nitinol. Other plasma gases such as, for example, argon can also be employed. The plasma gases employed can further optionally contain one or more additives customary in such a process step, such as, for example, allyl, vinylbenzene, etc. In step (b) of the process according to the invention, an activation and cleaning of the nitinol surface by means of the plasma treatment takes place, whereby a complete and uniform oxidation and activation of the surface is brought about. At the same time, impurities or foreign bodies present are oxidized and the surface is cleaned.
In this connection, it is to be mentioned that the activation and coating of the surface, as described in DE 196 13 048, removes a surface produced by electro-polishing and thus allows the escape of nickel or nickel ions. The procedure described in DE 196 13 048 is therefore unsuitable for the coating of nitinol implants or devices and leads to implants whose use brings about potential harm to the patient by the elution of nickel or nickel ions. Furthermore, as a result of the use of sulfuric acid described in DE 196 13 048 the formation of compounds of the type Ti0(S04) occurs, which dissolves and thus damages and destroys the Ti02 surface generated by the surface treatment.
Subsequently, in step (c) a hydroxylation of the nitinol surface, for example by. water, is optionally carried out and an adhesion promoter, preferably amino-propyltrimethoxysilane (APTMS) or aminopropyltriethoxy-silane, is applied to the surface and crosslinked.
A solution which contains at least one compound of the general formula (I) in a concentration of 0.1 to 99o by weight is then applied to this surface in step (d), customarily by spraying or dipping. As possible solvents, ethyl acetate, acetone, THF, toluene or xylenes can be used here. However, the choice of the solvents or solvent mixtures is not restricted to the solvents mentioned.
The evaporation of the solvent can proceed without further measures. Customarily, the concentration of the solvent vapor above the substrate, the pressure and the temperature is controlled. At the beginning of the first drying phase, an atmosphere saturated with the solvent vapor is customarily established above the coated substrate, the concentration of the solvent vapor subsequently being slowly reduced over a number of hours. The temperature can vary here from -30°C to +90°C. During the first drying phase, the pressure can run through a ramp from normal pressure to water jet vacuum (20 torr). After the first drying phase, the coated substrate is then dried further for a certain time in an oil pump vacuum (0.1 torr).
The device coated with the dried polymer of the compound (I) based on nitinol can then be directly further used after appropriate sterilization and further processed in the cold, i.e. compressed.
Depending on the concentration of the solution of the polymer compound (I) and the conditions during the first drying phase, various layer thicknesses of from 0.1 nm to 300 ~m or thicker, preferably in the range from 500 nm to 30 Vim, and particularly preferably around 100 nm, can be produced.
The structuring of the polymer coating is subject to no specific restriction. Thus structures of the order of magnitude of nanometers, micrometers or even larger or smaller, preferably in the range from 10 nm to 100 um, can be produced. Furthermore, all structures can be produced and used which can be generated photolithographically or using electron beams, X-rays or laser beams or by means of other techniques.
A microstructuring of the coating can also be obtained by means of direct "writing" on a film produced beforehand based on at least one polyphosphazene derivative according to the above formula (I) by means of laser beams, electron beams or X-rays or else by "melt structuring", where a thin wire is brought to the melting temperature of the polymer, which then melts the desired structure into the coating by direct contact. Particular advantages can be achieved by a structuring of this type in that structures are imprinted in the film which particularly favorably arrange the flow behavior of liquids (e.g. sharkskin or lotus effect).
This object is achieved by the embodiments characterized in the claims. In particular, a device is made available comprising a substrate based essentially on nitinol and, arranged thereon at least partially, a covering or a coating based on at least one polymer having the following general formula (I), ~1 ~2 ~3 P-N-P-N-P=N' R4 F~,s Rd in which n is 2 to oo, the radicals Rl to R6 are identical or different and are an alkoxy, alkyl-sulfonyl, dialkylamino or aryloxy radical or a hetero-cycloalkyl or heteroaryl radical having nitrogen as a hetero atom.
A further subject of the present invention is the use of the device according to the invention as an artificial implant, vascular or nonvascular stmt, catheter, thrombolectomy or embolectomy catheter, fragmentation spindle or catheter, filter, vascular connector, hernia patch, oral, dental or throat implant, guide wire or urether, preferably as a _ 7 _ vascular or nonvascular stmt or as an oral, dental or throat implant.
Surprisingly, the device according to the invention exhibits a high physical compatibility and a very good hemocompatibility. Moreover, the device according to the invention shows essentially no adsorption of macrophages or colonization of bacteria. The polyphosphazene having the above formula (I) specifically selected in the context of the present invention for the coating of the substrate based on nitinol withstands in a particularly advantageous manner the in some cases extreme temperature variations and mechanical stresses in the course of the processing of the nitinol substrate without becoming brittle, detaching or tearing. As a result of the specifically selected polyphosphazene having the above formula (I), the surface properties of nitinol are permanently improved, since the specifically selected poly-phosphazene derivative according to the general formula (I) is degraded neither hydrolytically nor enzymatically. Advantageously, the specifically selected polyphosphazene having the above formula (I) is elastic over a very wide temperature range, in particular at temperatures below the freezing point, without the use of plasticizers.
The degree of polymerization of the polymer according to the above formula (I) used for the coating of the nitinol substrate is 2 to oo. A range for the degree of polymerization of from 20 to 200,000, more preferably of from 40 to 100,000, is preferred.
Preferably, at least one of the radicals R1 to R6 in the polymer used is an alkoxy radical which is substituted by at least one fluorine atom.
The alkyl radicals in the alkoxy, alkylsulfonyl and dialkylamino radicals are, for example, straight- or branched-chain alkyl radicals having 1 to 20 carbon atoms, where the alkyl radicals can be substituted, for example, by at least one halogen atom, such as a fluorine atom.
Examples of alkoxy radicals are methoxy, ethoxy, propoxy and butoxy groups, which can preferably be substituted by at least one fluorine atom. The 2,2.,2-trifluoroethoxy group is particularly preferred.
Examples of alkylsulfonyl radicals are methyl-, ethyl-, propyl- and butylsulfonyl groups. Examples of dialkylamino radicals are dimethyl-, diethyl-, dipropyl- and dibutylamino groups.
The aryl radical in the aryloxy radical is, for example, an aryl unit having one or more aromatic ring systems, where the aryl radical can be substituted, for example, by at least one alkyl radical defined above.
Examples of aryloxy radicals are phenoxy and naphthoxy groups and derivatives thereof.
The heterocycloalkyl radical is, for example, a ring systems containing 3 to 7 atoms, where at least one ring atom is a nitrogen atom. The heterocycloalkyl radical can be substituted, for example, by at least one alkyl radical defined above. Examples of heterocycloalkyl radicals are piperidinyl, piperazinyl, pyrrolidinyl and morpholinyl groups and derivatives thereof. The heteroaryl radical is, for example, a compound having one or more aromatic ring systems, where at least one ring atom is a nitrogen atom. The heteroaryl radical can be substituted, for example, by at least one alkyl radical defined above. Examples of heteroaryl radicals are pyrrolyl, pyridinyl, pyridinolyl, isoquinolyl and quinolyl groups, and derivatives thereof.
In a preferred embodiment of the present invention, the polymer is poly[bis(trifluoroethoxy)phosphazene]. The _ g _ polymer can also be a poly[bis(trifluoroethoxy)-phosphazene] labelled by 3zp, aaP or As or Sb isotopes.
As a volume material, the polymeric compound poly[bis(trifluoroethoxy)phosphazene] shows a good antithrombogenic action (cf. Tur, Investigations on the thrombus resistance of poly[bis(trifluoroethoxy)-phosphazene] and Hollemann Wiberg, "Stickstoff-verbindungen des Phosphors" [Nitrogen compounds of phosphorus], Textbook of inorganic chemistry, 666-669, 91st-100th edition, Walter de Gruyter Verlag, 1985, and Tur, Vinogradova, inter alia "Entwicklungstendenzen bei polymeranalogen Umsetzungen von Polyphosphazen"
[Development tendencies in polymer-analogous reactions of polyphosphazene], Acta Polymerica 39, 424-429, no. 8, 1988. In DE 196 13 048 A1, the fluorinated form of polyphosphazenes was employed as a coating for the coating of artificial implants, heart valves expressly being mentioned. Such implants, however, are not produced from nitinol. Moreover, no disclosure is found in DE 196 13 048 A1 with respect to the aspect of the extreme temperature stresses in nitinol implants.
The devices according to the invention on the one hand have excellent mechanical and body-compatible properties and on the other hand a high resistance against inflammation-promoting organisms, such as, for example, macrophages. As a result of the coating of the nitinol surface with the specifically selected polyphosphazene having the above formula (I), on the one hand the hemo- and biocompatibility of the surface mentioned is improved, on the other hand in the application of the coating or of the covering the surface layer sealing the nitinol surface generated by electropolishing or other techniques is not damaged.
Thus possible subsequent damage after implantation can be reduced.
In the context of the present invention, the substrate based on nitinol can be partially coated with a covering based on at least one polymer having the general formula (I). Customarily, however, it is preferred that the substrate is based on nitinol coated completely with a covering based on at least one polymer having the general formula (I).
In one embodiment of the present invention, the nitinol substrate, which coated thereon has a covering of the polyphosphazene polymer according to the formula (I), is present in the form of an at least partially pierced or perforated tube, such as is customary, for example, in the case of an endovascular implant, such as a stmt .
The covering of at least one polyphosphazene polymer according to the formula (I) according to the present invention arranged or deposited on the nitinol substrate can further comprise one or more pharmaceutically active compounds, such as, for example, cytotoxic compounds, such as rapamycin, taxol, doxorubicin, platinum derivatives, 5-fluoracyl or antiinflammatory active compounds such as diclofenac or acetylsalicylic acid or other active compounds in a corresponding .pharmaceutical preparation, preferably having delayed release or quantitatively controlled release over a relatively long period.
The covering of the device according to the invention has, for example, a thickness of approximately 1 nm to approximately 100 um, preferably to approximately 500 nm and particularly preferably to approximately 100 nm.
In one embodiment of the artificial implant according to the invention, between the surface of the substrate and the covering constructed from the polyphosphazene derivative is arranged a layer which contains an adhesion promoter, i.e. adjacent to the coating based on at least one polymer having the general formula (I) is arranged an adhesion promoter layer.
The adhesion promoter or spacer preferably contains a polar end group. Examples of these are hydroxyl, carboxylate, aldehyde, amino or vitro groups. However, end groups based on an alkoxy, alkylsulfonyl, dialkylamino or aryloxy radical or a heterocycloalkyl or heteroaryl radical having nitrogen as a heteroatom can also be present, where these radicals can also be differently substituted, for example by halogen atoms, in particular fluorine.
In particular, the adhesion promoter can be, for example, an organosilicon compound, preferably an amino-terminated silane or a compound based on an aminosilane, an amino-terminated alkene, a nitro-terminated alkene, a vitro-terminated silane or an alkylphosphonic acid. As adhesion promoter, amino-propyltrimethoxysilane and aminopropyltriethoxysilane are particularly preferred.
The adhesion promoter in particular improves the adhesion of the covering to the surface of the nitinol substrate by coupling of the adhesion promoter to the nitinol surface, for example by means of ionic and/or covalent bonds, and further coupling to the described polymer of the formula (I) of the covering, for example by means of ionic and/or covalent bonds.
A further subject of the present invention relates to the production of the device according to the invention, comprising the steps:
(a) making available of a substrate based on nitinol, (b) exposure of the nitinol surface to a plasma treatment, (c) optionally hydroxylation of the surface treated in step (b) and application of an adhesion promoter and (d) coating of the substrate with at least one polymer of the abovementioned formula (I).
The substrate based on nitinol can be made available in step (a), for example, in the form of an at least partially pierced or perforated tube. The substrate essentially comprises nitinol as the material forming the substrate. The substrate based on nitinol can in the course of this already be subjected to an electropolishing or other treatment for the production of a surface which is leakproof and impermeable to nickel ions.
In step (b) of the process according to the invention, a plasma treatment of the nitinol surface takes place, the plasma preferably being an air or oxygen plasma. By means of the plasma treatment, an ultrathin, leakproof Ti02 layer is produced on the substrate based essentially on nitinol. Other plasma gases such as, for example, argon can also be employed. The plasma gases employed can further optionally contain one or more additives customary in such a process step, such as, for example, allyl, vinylbenzene, etc. In step (b) of the process according to the invention, an activation and cleaning of the nitinol surface by means of the plasma treatment takes place, whereby a complete and uniform oxidation and activation of the surface is brought about. At the same time, impurities or foreign bodies present are oxidized and the surface is cleaned.
In this connection, it is to be mentioned that the activation and coating of the surface, as described in DE 196 13 048, removes a surface produced by electro-polishing and thus allows the escape of nickel or nickel ions. The procedure described in DE 196 13 048 is therefore unsuitable for the coating of nitinol implants or devices and leads to implants whose use brings about potential harm to the patient by the elution of nickel or nickel ions. Furthermore, as a result of the use of sulfuric acid described in DE 196 13 048 the formation of compounds of the type Ti0(S04) occurs, which dissolves and thus damages and destroys the Ti02 surface generated by the surface treatment.
Subsequently, in step (c) a hydroxylation of the nitinol surface, for example by. water, is optionally carried out and an adhesion promoter, preferably amino-propyltrimethoxysilane (APTMS) or aminopropyltriethoxy-silane, is applied to the surface and crosslinked.
A solution which contains at least one compound of the general formula (I) in a concentration of 0.1 to 99o by weight is then applied to this surface in step (d), customarily by spraying or dipping. As possible solvents, ethyl acetate, acetone, THF, toluene or xylenes can be used here. However, the choice of the solvents or solvent mixtures is not restricted to the solvents mentioned.
The evaporation of the solvent can proceed without further measures. Customarily, the concentration of the solvent vapor above the substrate, the pressure and the temperature is controlled. At the beginning of the first drying phase, an atmosphere saturated with the solvent vapor is customarily established above the coated substrate, the concentration of the solvent vapor subsequently being slowly reduced over a number of hours. The temperature can vary here from -30°C to +90°C. During the first drying phase, the pressure can run through a ramp from normal pressure to water jet vacuum (20 torr). After the first drying phase, the coated substrate is then dried further for a certain time in an oil pump vacuum (0.1 torr).
The device coated with the dried polymer of the compound (I) based on nitinol can then be directly further used after appropriate sterilization and further processed in the cold, i.e. compressed.
Depending on the concentration of the solution of the polymer compound (I) and the conditions during the first drying phase, various layer thicknesses of from 0.1 nm to 300 ~m or thicker, preferably in the range from 500 nm to 30 Vim, and particularly preferably around 100 nm, can be produced.
The structuring of the polymer coating is subject to no specific restriction. Thus structures of the order of magnitude of nanometers, micrometers or even larger or smaller, preferably in the range from 10 nm to 100 um, can be produced. Furthermore, all structures can be produced and used which can be generated photolithographically or using electron beams, X-rays or laser beams or by means of other techniques.
A microstructuring of the coating can also be obtained by means of direct "writing" on a film produced beforehand based on at least one polyphosphazene derivative according to the above formula (I) by means of laser beams, electron beams or X-rays or else by "melt structuring", where a thin wire is brought to the melting temperature of the polymer, which then melts the desired structure into the coating by direct contact. Particular advantages can be achieved by a structuring of this type in that structures are imprinted in the film which particularly favorably arrange the flow behavior of liquids (e.g. sharkskin or lotus effect).
Claims (19)
1. A medical device comprising:
a substrate based essentially on nitinol; and at least partially disposed to cover the substrate, a coating based on at least one polymer having the following formula (I):
wherein n is at least 2, the groups R1 to R6 are the same or different, and represent an alkoxy, alkylsulfonyl, dialkylamino or aryloxy group, or a heterocycloalkyl or hetaroaryl group with nitrogen as the heteroatom.
a substrate based essentially on nitinol; and at least partially disposed to cover the substrate, a coating based on at least one polymer having the following formula (I):
wherein n is at least 2, the groups R1 to R6 are the same or different, and represent an alkoxy, alkylsulfonyl, dialkylamino or aryloxy group, or a heterocycloalkyl or hetaroaryl group with nitrogen as the heteroatom.
2. The medical device according to claim 1, wherein an ultra-thin TiO2 layer is disposed above the nitinol-based substrate, and is disposed below the coating.
3. The medical device according to claim 1 or claim 2, wherein the alkoxy group is substituted by at least one fluorine atom.
4. The medical device according to any one of claims 1 to 3, wherein the polymer is poly[bis(trifluoroethoxy)phosphazene].
5. The medical device according to any one of claims 1 to 4, wherein a layer containing an adhesion promoter is disposed above the nitinol-based substrate, and is disposed below the coating.
6. The medical device according to claim 5, wherein the adhesion promoter is a compound containing a polar terminal group.
7. The medical device according to claim 6, wherein the compound containing the polar terminal group is a silicon organic compound.
8. The medical device according to claim 7, wherein the silicon organic compound is aminopropyltrimethoxysilane.
9. The medical device according to any one of claims 1 to 8, wherein the nitinol-based substrate is completely coated with the coating.
10. The medical device according to any one of claims 1 to 9, wherein the nitinol-based substrate is used in the form of at least a partially perforated tube.
11. The medical device according to any one of claims 1 to 10, wherein the coating is microstructured.
12. The medical device according to any one of claims 1 to 11, selected from the group consisting of: an artificial implant, a vascular stent, a non-vascular stent, a fragmentation spindle, a guide wire, a filter, a vascular connector, a hernia patch, an oral implant, a dental implant, a throat implant, an ureter, a catheter, a thrombolectomy catheter, an embolectomy catheter, and a fragmentation catheter.
13. The medical device according to any one of claims 1 to 12, wherein the coating further comprises one or more pharmaceutically active compounds released in a controlled manner over an extended period.
14. The medical device according to any one of claims 1 to 13, wherein the coating has a thickness ranging from approximately 1 nm to approximately 100 µm.
15. A method for producing a medical device of claims 1-14 comprising a substrate based essentially on nitinol and, at least partially disposed to cover the substrate, a polymer coating, comprising the following steps:
providing a nitinol-based substrate;
exposing the nitinol-based substrate to a plasma treatment; and coating the substrate with at least one polymer as defined in any one of claims 1, 3, and 4.
providing a nitinol-based substrate;
exposing the nitinol-based substrate to a plasma treatment; and coating the substrate with at least one polymer as defined in any one of claims 1, 3, and 4.
16. The method according to claim 15, further comprising optionally hydroxylating the substrate subsequent to the plasma treatment and further applying an adhesion promoter, both prior to the coating step.
17. The method according to claim 15 or claim 16, wherein exposing the nitinol-based substrate to the plasma treatment includes the utilization of air, argon, or oxygen plasma.
18. The method according to any one of claims 15 to 17, further comprising microstructuring the polymer coating, by exposing to a laser beam, an electron beam or X-ray radiation, and/or a heated wire.
19. The method according to any one of claims 15 to 18, wherein coating the substrate with at least one polymer further comprises spraying or dipping in a polymer solution containing at least one compound of the general formula (I) at a concentration of about 0.1 to 99% by weight.
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DE10140522 | 2001-08-17 | ||
DE2002102467 DE10202467A1 (en) | 2002-01-23 | 2002-01-23 | Device, useful as an artificial implant, comprises a substrate based on nitinol having at least a partial coating of a phosphazene polymer. |
DE10202467.7 | 2002-01-23 | ||
PCT/EP2002/009017 WO2003015719A1 (en) | 2001-08-17 | 2002-08-12 | Device based on nitinol with a polyphosphazene coating |
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-
2002
- 2002-08-12 WO PCT/EP2002/009017 patent/WO2003015719A1/en active IP Right Grant
- 2002-08-12 EP EP02794780A patent/EP1432380B1/en not_active Expired - Lifetime
- 2002-08-12 PT PT02794780T patent/PT1432380E/en unknown
- 2002-08-12 ES ES02794780T patent/ES2272807T3/en not_active Expired - Lifetime
- 2002-08-12 DK DK02794780T patent/DK1432380T3/en active
- 2002-08-12 AT AT02794780T patent/ATE340551T1/en active
- 2002-08-12 DE DE50208282T patent/DE50208282D1/en not_active Expired - Lifetime
- 2002-08-12 US US10/486,809 patent/US20040253467A1/en not_active Abandoned
- 2002-08-12 CA CA2457018A patent/CA2457018C/en not_active Expired - Lifetime
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2007
- 2007-03-19 US US11/725,709 patent/US8101275B2/en not_active Expired - Fee Related
-
2012
- 2012-01-23 US US13/356,639 patent/US8313841B2/en not_active Expired - Lifetime
Also Published As
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ATE340551T1 (en) | 2006-10-15 |
PT1432380E (en) | 2007-01-31 |
DE50208282D1 (en) | 2006-11-09 |
US20120118436A1 (en) | 2012-05-17 |
US8101275B2 (en) | 2012-01-24 |
CA2457018A1 (en) | 2003-02-27 |
EP1432380B1 (en) | 2006-09-27 |
US20040253467A1 (en) | 2004-12-16 |
WO2003015719A1 (en) | 2003-02-27 |
ES2272807T3 (en) | 2007-05-01 |
EP1432380A1 (en) | 2004-06-30 |
DK1432380T3 (en) | 2007-01-15 |
US20070184277A1 (en) | 2007-08-09 |
US8313841B2 (en) | 2012-11-20 |
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