CA2457677A1 - Micro needles and method of manufacture thereof - Google Patents

Micro needles and method of manufacture thereof Download PDF

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Publication number
CA2457677A1
CA2457677A1 CA002457677A CA2457677A CA2457677A1 CA 2457677 A1 CA2457677 A1 CA 2457677A1 CA 002457677 A CA002457677 A CA 002457677A CA 2457677 A CA2457677 A CA 2457677A CA 2457677 A1 CA2457677 A1 CA 2457677A1
Authority
CA
Canada
Prior art keywords
needle
mask
extension
optionally
support member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002457677A
Other languages
French (fr)
Other versions
CA2457677C (en
Inventor
Goran Stemme
Patrick Griss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bonsens AB
Original Assignee
Bonsens Ab
Goran Stemme
Patrick Griss
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bonsens Ab, Goran Stemme, Patrick Griss filed Critical Bonsens Ab
Publication of CA2457677A1 publication Critical patent/CA2457677A1/en
Application granted granted Critical
Publication of CA2457677C publication Critical patent/CA2457677C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Abstract

A micro-needle according to the invention protrudes from a support member. The needle comprises a needle body portion, a closed pointed tip portion, and an inner lumen extending through said support member and into said protruding needle. The needle body portion has at least one side opening communicating with said inner lumen. The method of making the needle comprises providing a mask on the front side of an etchable wafer such that the vertical projection of said mask at least partially covers the extension of a hole made in the back side. Said mask is isotropically underetched to remove wafer material. An anisotropic etch forms a protruding structure. Optionally a second isotropic etch on said protruding structure exposes the blind hole. Optionally a final anisotropic etch extends the needle without forming side openings. The position and extension of the mask relative the position and dimension of the hole is such that said side openings form during either said anisotropic etc or said second isotropic etch.
CA002457677A 2001-08-14 2002-08-14 Micro needles and method of manufacture thereof Expired - Lifetime CA2457677C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0102736A SE0102736D0 (en) 2001-08-14 2001-08-14 Side opened out-of-plane microneedles for microfluidic transdermal interfacing and fabrication process of side opened out-of-plane microneedles
SE0102736-6 2001-08-14
PCT/SE2002/001456 WO2003015860A1 (en) 2001-08-14 2002-08-14 Micro needeles and method of manufacture thereof

Publications (2)

Publication Number Publication Date
CA2457677A1 true CA2457677A1 (en) 2003-02-27
CA2457677C CA2457677C (en) 2009-10-06

Family

ID=20285040

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002457677A Expired - Lifetime CA2457677C (en) 2001-08-14 2002-08-14 Micro needles and method of manufacture thereof

Country Status (9)

Country Link
US (2) US7258805B2 (en)
EP (1) EP1416996B1 (en)
JP (1) JP4348181B2 (en)
AT (1) ATE342748T1 (en)
AU (1) AU2002326256B2 (en)
CA (1) CA2457677C (en)
DE (1) DE60215516T2 (en)
SE (1) SE0102736D0 (en)
WO (1) WO2003015860A1 (en)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL134997A0 (en) * 2000-03-09 2001-05-20 Yehoshua Yeshurun Health care system based on micro device
US6830562B2 (en) 2001-09-27 2004-12-14 Unomedical A/S Injector device for placing a subcutaneous infusion set
US20040051019A1 (en) 2002-09-02 2004-03-18 Mogensen Lasse Wesseltoft Apparatus for and a method of adjusting the length of an infusion tube
DK200201823A (en) 2002-11-26 2004-05-27 Maersk Medical As Connection piece for a hose connection
US7415299B2 (en) * 2003-04-18 2008-08-19 The Regents Of The University Of California Monitoring method and/or apparatus
FR2862006B1 (en) * 2003-11-12 2006-01-27 Univ Lille Sciences Tech PLANAR ELECTRONEBULATING SOURCES ON THE MODEL OF A CALLIGRAPHIC FEATHER AND THEIR MANUFACTURE.
US7998119B2 (en) * 2003-11-18 2011-08-16 Nano Pass Technologies Ltd. System and method for delivering fluid into flexible biological barrier
WO2005060621A2 (en) * 2003-11-21 2005-07-07 The Regents Of The University Of California Method and/or apparatus for puncturing a surface for extraction, in situ analysis, and/or substance delivery using microneedles
US8551391B2 (en) 2004-02-17 2013-10-08 Avery Dennison Corporation Method of making microneedles
CN1929784B (en) 2004-03-06 2010-09-29 霍夫曼-拉罗奇有限公司 Body fluid sampling device
US7819822B2 (en) * 2004-03-06 2010-10-26 Roche Diagnostics Operations, Inc. Body fluid sampling device
WO2005087305A1 (en) * 2004-03-12 2005-09-22 Agency For Science, Technology And Research Methods and moulds for use in fabricating side-ported microneedles
ES2323793T3 (en) 2004-03-26 2009-07-24 Unomedical A/S INFUSION SET
US7560036B2 (en) * 2004-08-05 2009-07-14 Apogee Technology, Inc. System and method for drug delivery and microfluidic applications using microneedles
US8062250B2 (en) 2004-08-10 2011-11-22 Unomedical A/S Cannula device
US20060040390A1 (en) * 2004-08-19 2006-02-23 Minor John S Jr Device, method, system, and program for intelligent in vivo cell-level chemical or genetic material delivery
SE0402100D0 (en) 2004-08-30 2004-08-30 Bonsens Ab Molded micro-needles
US7132054B1 (en) * 2004-09-08 2006-11-07 Sandia Corporation Method to fabricate hollow microneedle arrays
EP1819379B1 (en) 2004-11-18 2016-08-31 Nanopass Technologies Ltd. System for delivering fluid into flexible biological barrier
US7867199B2 (en) 2004-12-10 2011-01-11 Unomedical A/S Inserter
EP1669100A1 (en) 2004-12-13 2006-06-14 Debiotech S.A. Micro-needle
US7985199B2 (en) 2005-03-17 2011-07-26 Unomedical A/S Gateway system
WO2006105146A2 (en) 2005-03-29 2006-10-05 Arkal Medical, Inc. Devices, systems, methods and tools for continuous glucose monitoring
EP1762259B1 (en) 2005-09-12 2010-09-08 Unomedical A/S Inserter for an infusion set with a first and second spring units
USD655807S1 (en) 2005-12-09 2012-03-13 Unomedical A/S Medical device
EP1962679B1 (en) * 2005-12-14 2012-04-11 Silex Microsystems AB Methods for making micro needles and applications thereof
EP1962942A1 (en) * 2005-12-21 2008-09-03 3M Innovative Properties Company Microneedle devices
PT1962926E (en) 2005-12-23 2009-08-27 Unomedical As Injection device
US9211379B2 (en) 2006-02-28 2015-12-15 Unomedical A/S Inserter for infusion part and infusion part provided with needle protector
WO2007112309A2 (en) * 2006-03-24 2007-10-04 3M Innovative Properties Company Process for making microneedles, microneedle arrays, masters, and replication tools
KR20090026760A (en) 2006-06-07 2009-03-13 우노메디컬 에이/에스 Inserter
KR20090028701A (en) 2006-06-09 2009-03-19 우노메디컬 에이/에스 Mounting pad
DE102006028781A1 (en) * 2006-06-23 2007-12-27 Robert Bosch Gmbh Process for making porous microneedles and their use
US8865288B2 (en) 2006-07-17 2014-10-21 University Of Utah Research Foundation Micro-needle arrays having non-planar tips and methods of manufacture thereof
US20080138581A1 (en) * 2006-07-17 2008-06-12 Rajmohan Bhandari Masking high-aspect aspect ratio structures
US7951300B2 (en) * 2006-07-17 2011-05-31 University Of Utah Research Foundation Water-scale needle array
EP2047882B1 (en) 2006-07-27 2014-09-10 Toppan Printing Co., Ltd. Microneedle and method for producing microneedle
JP2009545341A (en) 2006-08-02 2009-12-24 ウノメディカル アクティーゼルスカブ Cannula and delivery device
JP2010502267A (en) * 2006-08-28 2010-01-28 エージェンシー・フォー・サイエンス・テクノロジー・アンド・リサーチ Microneedle and method for producing microneedle
WO2008036043A1 (en) * 2006-09-18 2008-03-27 Agency For Science, Technology And Research Needle structures and methods for fabricating needle structures
EP1917990A1 (en) 2006-10-31 2008-05-07 Unomedical A/S Infusion set
US7713196B2 (en) * 2007-03-09 2010-05-11 Nellcor Puritan Bennett Llc Method for evaluating skin hydration and fluid compartmentalization
US20090011158A1 (en) * 2007-03-18 2009-01-08 Nanopass Technologies Ltd. Microneedle structures and corresponding production methods employing a backside wet etch
JP2010529891A (en) * 2007-06-15 2010-09-02 ライフスキャン・インコーポレイテッド Flexible cannula or medical device conduit
AU2008266382B2 (en) 2007-06-20 2013-06-27 Unomedical A/S A catheter and a method and an apparatus for making such catheter
WO2009004026A1 (en) 2007-07-03 2009-01-08 Unomedical A/S Inserter having bistable equilibrium states
KR20100062991A (en) 2007-07-10 2010-06-10 우노메디컬 에이/에스 Inserter having two springs
WO2009010396A1 (en) 2007-07-18 2009-01-22 Unomedical A/S Insertion device with pivoting action
MY157968A (en) * 2007-11-14 2016-08-30 Mimos Berhad Method for fabricating microneedled and microneedle fabricated from the same
US9022973B2 (en) 2007-12-17 2015-05-05 New World Pharmaceuticals, Llc Integrated intra-dermal delivery, diagnostic and communication system
EP2072076A1 (en) 2007-12-17 2009-06-24 Debiotech S.A. Out-of-plane microneedle manufacturing process
GB0802447D0 (en) * 2008-02-09 2008-03-19 Univ Manchester Fluid extraction device, associated materials and methods
CA2713485A1 (en) 2008-02-13 2009-08-20 Unomedical A/S Sealing between a cannula part and a fluid path
MX2010009087A (en) 2008-02-20 2011-05-03 Unomedical As Insertion device with horizontally moving part.
US20090301994A1 (en) * 2008-05-12 2009-12-10 Rajmohan Bhandari Methods for Wafer Scale Processing of Needle Array Devices
US8886279B2 (en) 2008-06-03 2014-11-11 University Of Utah Research Foundation High aspect ratio microelectrode arrays enabled to have customizable lengths and methods of making the same
NL2001718C2 (en) 2008-06-24 2009-12-28 Needle Holding B V U Micro needle, micro needle array and manufacturing method therefor.
AU2009331635A1 (en) 2008-12-22 2011-06-23 Unomedical A/S Medical device comprising adhesive pad
FI20095433A0 (en) 2009-04-20 2009-04-20 Valtion Teknillinen micro-needle
EP2275164A1 (en) 2009-07-15 2011-01-19 Debiotech S.A. Multichannel micro-needles
US9526885B1 (en) * 2009-07-29 2016-12-27 University Of South Florida Microneedles with sharpened tips and corresponding method of fabrication
AU2010277755A1 (en) 2009-07-30 2012-02-02 Unomedical A/S Inserter device with horizontal moving part
JP2013500805A (en) 2009-08-07 2013-01-10 ウノメディカル・アー／エス Dosing device having a sensor and one or more cannulas
US20110144591A1 (en) * 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
EP2338557A1 (en) 2009-12-23 2011-06-29 Debiotech S.A. Soluble microneedle
JP2013517889A (en) * 2010-01-29 2013-05-20 ユーバイオメッド インク． Microneedle and microneedle device
EP2552513B1 (en) 2010-03-30 2014-03-19 Unomedical A/S Medical device
CA2796965C (en) 2010-04-28 2019-04-16 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
JP5592147B2 (en) * 2010-04-28 2014-09-17 ヤマハ株式会社 Silicon nanoneedle and manufacturing method thereof
MX336139B (en) 2010-04-28 2016-01-08 Kimberly Clark Co MEDICAL DEVICES FOR DELIVERY OF siRNA.
MX345837B (en) 2010-04-28 2017-02-16 Kimberly-Clark Worldwide Incorporated Device for delivery of rheumatoid arthritis medication.
AU2011246882B2 (en) 2010-04-28 2016-02-25 Sorrento Therapeutics, Inc. Nanopatterned medical device with enhanced cellular interaction
KR101180032B1 (en) 2010-07-12 2012-09-05 인싸이토(주) Method for manufacturing Hollow Microneedle with Controlled External Appearance Characteristics
EP2433663A1 (en) 2010-09-27 2012-03-28 Unomedical A/S Insertion system
EP2436412A1 (en) 2010-10-04 2012-04-04 Unomedical A/S A sprinkler cannula
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
US8636696B2 (en) 2011-06-10 2014-01-28 Kimberly-Clark Worldwide, Inc. Transdermal device containing microneedles
CN103813750B (en) * 2011-09-23 2016-08-17 霍夫曼-拉罗奇有限公司 A kind of method piercing through element is etched for mask
EP2763723B1 (en) 2011-10-05 2016-04-13 Unomedical A/S Inserter for simultaneous insertion of multiple transcutaneous parts
EP2583715A1 (en) 2011-10-19 2013-04-24 Unomedical A/S Infusion tube system and method for manufacture
US9440051B2 (en) 2011-10-27 2016-09-13 Unomedical A/S Inserter for a multiplicity of subcutaneous parts
EP3574950B1 (en) 2011-10-27 2021-02-17 Sorrento Therapeutics, Inc. Transdermal delivery of high viscosity bioactive agents
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
EP2662110A1 (en) 2012-05-10 2013-11-13 Debiotech S.A. Device and method for inserting needles
JP6269111B2 (en) * 2013-01-31 2018-01-31 生化学工業株式会社 Microneedle and microneedle array
WO2014126834A2 (en) 2013-02-12 2014-08-21 Eipi Systems, Inc. Method and apparatus for three-dimensional fabrication with feed through carrier
CN107073813B (en) 2014-06-20 2019-07-05 卡本有限公司 Use the 3 D-printing of the reciprocal feeding of polymerizable liquid
WO2016149152A1 (en) * 2015-03-13 2016-09-22 The University Of North Carolina At Chapel Hill Polymeric microneedles and rapid additive manufacturing of the same
KR20170141200A (en) * 2015-04-13 2017-12-22 벨루스 메디칼, 엘엘씨 Collagen stimulation device and method
WO2017156347A1 (en) * 2016-03-09 2017-09-14 Incube Labs, Llc Methods and articles for delivering viable cells into solid tissue
KR20170115429A (en) * 2016-04-07 2017-10-17 랩앤피플주식회사 Micro needle Using the Bioabsorbable Metal
US11241563B2 (en) 2016-12-22 2022-02-08 Johnson & Johnson Consumer Inc. Microneedle arrays and methods for making and using
JP6525017B2 (en) * 2017-01-27 2019-06-05 大日本印刷株式会社 Microneedle device
WO2018181700A1 (en) * 2017-03-31 2018-10-04 凸版印刷株式会社 Percutaneous administration device
JP6304431B2 (en) * 2017-06-01 2018-04-04 大日本印刷株式会社 Microneedle device
CA3101595A1 (en) * 2018-06-29 2020-01-02 Johnson & Johnson Consumer Inc. Three-dimensional microfluidics devices for the delivery of actives
CN111228642A (en) * 2020-02-12 2020-06-05 成都工业学院 Hollow microneedle array device and manufacturing method

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2535602B1 (en) 1982-11-05 1986-06-13 Stallergenes Lab SCARIFIER DEVICE
US5312456A (en) * 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
DE19525607A1 (en) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneal drug delivery system
CA2253549C (en) * 1996-06-18 2005-10-25 Alza Corporation Device for enhancing transdermal agent delivery or sampling
US6610235B1 (en) 1997-06-30 2003-08-26 The Regents Of The University Of California Method of fabricating epidermal abrasion device
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
GB9815820D0 (en) * 1998-07-22 1998-09-16 Secr Defence Improvements relating to micro-machining
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6406638B1 (en) * 2000-01-06 2002-06-18 The Regents Of The University Of California Method of forming vertical, hollow needles within a semiconductor substrate, and needles formed thereby
JP2003520094A (en) * 2000-01-21 2003-07-02 インストルメンタリウム コーポレイション Medical electrode
US6558361B1 (en) * 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6565532B1 (en) * 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
US7108681B2 (en) * 2000-10-16 2006-09-19 Corium International, Inc. Microstructures for delivering a composition cutaneously to skin
DE10065168A1 (en) * 2000-12-23 2002-07-11 Lohmann Therapie Syst Lts Device for transdermal administration of active substances, with a plurality of micro needles or blades on a plaster for penetration of the outer skin layer, is provided with a biocidal agent
US6767341B2 (en) * 2001-06-13 2004-07-27 Abbott Laboratories Microneedles for minimally invasive drug delivery
US6962772B2 (en) * 2002-12-27 2005-11-08 Industrial Technology Research Inst. Method for manufacturing 3-D high aspect-ratio microneedle array device
US7132054B1 (en) * 2004-09-08 2006-11-07 Sandia Corporation Method to fabricate hollow microneedle arrays

Also Published As

Publication number Publication date
ATE342748T1 (en) 2006-11-15
DE60215516D1 (en) 2006-11-30
US7258805B2 (en) 2007-08-21
JP2004538106A (en) 2004-12-24
AU2002326256B2 (en) 2008-05-22
JP4348181B2 (en) 2009-10-21
WO2003015860A1 (en) 2003-02-27
SE0102736D0 (en) 2001-08-14
DE60215516T2 (en) 2007-08-30
EP1416996A1 (en) 2004-05-12
CA2457677C (en) 2009-10-06
US7901387B2 (en) 2011-03-08
US20040267205A1 (en) 2004-12-30
US20080039806A1 (en) 2008-02-14
EP1416996B1 (en) 2006-10-18

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