CA2465901A1 - Collapsible syringe cartridge - Google Patents

Collapsible syringe cartridge Download PDF

Info

Publication number
CA2465901A1
CA2465901A1 CA002465901A CA2465901A CA2465901A1 CA 2465901 A1 CA2465901 A1 CA 2465901A1 CA 002465901 A CA002465901 A CA 002465901A CA 2465901 A CA2465901 A CA 2465901A CA 2465901 A1 CA2465901 A1 CA 2465901A1
Authority
CA
Canada
Prior art keywords
casing
syringe cartridge
fixed portion
collapsible
syringe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002465901A
Other languages
French (fr)
Other versions
CA2465901C (en
Inventor
Pedro De La Serna
Scott Jay Gilbert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2465901A1 publication Critical patent/CA2465901A1/en
Application granted granted Critical
Publication of CA2465901C publication Critical patent/CA2465901C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/206—With automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31518—Piston or piston-rod constructions, e.g. connection of piston with piston-rod designed to reduce the overall size of an injection device, e.g. using flexible or pivotally connected chain-like rod members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/3271—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel with guiding tracks for controlled sliding of needle protective sleeve from needle exposing to needle covering position
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion

Abstract

The present invention provides a syringe cartridge that is sufficiently robu st to be used in autoinjectors that generate injection forces sufficient to deliver viscous medicaments. The syringe cartridge (100) of the present invention includes a syringe (200), a bias mechanism (300), and a casing. Th e casing of the syringe cartridge of the present invention includes a collapsible portion (430) and a fixed portion (460). Advantageously, the collapsible portion (430) of the casing collapses within the fixed portion (460) of the casing as the syringe (200) is driven through its stroke within the syringe cartridge. As the collapsible portion collapses within the fixed portion, the length of the syringe cartridge (100) is effectively reduced, which, in turn, allows the use of a shorter plunger and thereby facilitates the construction of a more compact autoinjector.

Claims (18)

1. A syringe cartridge exhibiting a first length and comprising a syringe with an associated needle and a casing that includes a fixed portion and a collapsible portion, wherein the syringe is positioned through the collapsible portion of the casing and the syringe, the fixed portion of the casing and the collapsible portion of the casing are configured such that, upon application of a force to the syringe, the collapsible portion of the casing is motivated into the fixed portion of the casing and the first length of the casing is reduced.
2. The syringe cartridge of claim 1, further comprising a bias member.
3. The syringe cartridge of claim 2, wherein the bias member biases the collapsible portion of the casing in a normally extended position relative to the fixed portion of the casing such that the needle associated with the syringe is normally retracted within the fixed portion of the casing.
4. The syringe cartridge of claim 2, wherein the bias member is selected from a group consisting of a spring, a fluid filled bladder, and a natural or synthetic rubber or polymer material.
5. The syringe cartridge of claim 1, wherein the casing further comprises a mounting mechanism configured to allow the syringe cartridge to be removably mounted to an injection device.
6. The syringe cartridge of claim 1, wherein the casing further comprises a first set of threads complimentary to a second set of threads included in an injection device.
7. The syringe cartridge of claim 6, wherein the first and second sets of complimentary threads are configured to allow the syringe cartridge to be removably mounted within the injection device.
8. The syringe cartridge of claim 1, wherein the casing further comprises one or more locking tabs that are complimentary to a locking ring included in an injection device.
9. The syringe cartridge of claim 8, wherein the one or more locking tabs and the complimentary locking ring are configured to allow the syringe cartridge to be removably mounted within the injection device.
10. The syringe cartridge of claim 1, wherein the fixed portion of the casing further comprises an adjustable tip.
11.The syringe cartridge of claim 1, further comprising a mechanism configured to lock the collapsible portion of the casing relative to the fixed portion of the casing such that movement of the collapsible portion of the casing within the fixed portion of the casing is prevented.
12. The syringe cartridge of claim 1, further comprising:
a locking mechanism configured to transition between a locked position, wherein movement of the collapsible portion of the casing within the fixed portion of the casing is prevented, and an unlocked position, wherein movement of the collapsible portion of the casing within the fixed portion of the casing is permitted; and an interlock mechanism configured to maintain the locking mechanism in the locked position as the locked position is achieved or in the unlocked position as the unlocked position is achieved.
13. The syringe cartridge of claim 1, further comprising:
a locking mechanism configured to transition between a locked position, wherein movement of the collapsible portion of the casing within the fixed portion of the casing is prevented, and an unlocked position, wherein movement of the collapsible portion of the casing within the fixed portion of the casing is permitted;
an interlock mechanism configured to maintain the locking mechanism in the locked position as the locked position is achieved or in the unlocked position as the unlocked position is achieved; and a mounting mechanism configured to allow the syringe cartridge to be mounted to an injection device.
14. The syringe cartridge of claim 1, further comprising:
a locking mechanism configured to transition between a locked position, wherein movement of the collapsible portion of the casing within the fixed portion of the casing is prevented, and an unlocked position, wherein movement of the collapsible portion of the casing within the fixed portion of the casing is permitted;
an interlock mechanism configured to maintain the locking mechanism in the locked position as the locked position is achieved or in the unlocked position as the unlocked position is achieved; and a mounting mechanism by which the syringe cartridge can be mounted to an injection device, the mounting mechanism being configured such that mounting of the syringe cartridge to the injection device facilitates actuation of the interlock mechanism and transitions the locking mechanism from the locked position to the unlocked position.
15. The syringe cartridge of claim 1, further comprising a locking mechanism configured to transition between a locked position, wherein movement of the collapsible portion of the casing within the fixed portion of the casing is prevented, and an unlocked position, wherein movement of the collapsible portion of the casing within the fixed portion of the casing is permitted.
16. The syringe cartridge of claim 15, wherein the locking mechanism is configured such that the locking mechanism can be transitioned between the locked and unlocked positions through rotational movement of the collapsible portion of the casing relative to the fixed portion of the casing.
17. The syringe cartridge of claim 1, wherein the collapsible portion of the casing includes one or more members extending away from an outer surface of the collapsible portion, the fixed portion of the casing includes one or more passages complimentary to the one or more members included on the outer surface of the collapsible portion, and the fixed and collapsible portions of the casing are configured such that, when the one or more members included on the outer surface of the collapsible portion are aligned with the one or more passages complimentary to the one or more members, the collapsible portion of the casing can be motivated into the fixed portion of the casing.
18. The syringe cartridge of claim 17, wherein the collapsible portion of the casing and the fixed portion of the casing are configured such that, when the one or more members included on the outer surface of the collapsible portion are not aligned with the one or more passages complimentary to the one or more members, the collapsible portion of the casing can not be motivated into the fixed portion of the casing.
CA2465901A 2001-11-09 2002-11-08 Collapsible syringe cartridge Expired - Fee Related CA2465901C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33768101P 2001-11-09 2001-11-09
US60/337,681 2001-11-09
PCT/US2002/035876 WO2003041770A2 (en) 2001-11-09 2002-11-08 Collapsible syringe cartridge

Publications (2)

Publication Number Publication Date
CA2465901A1 true CA2465901A1 (en) 2003-05-22
CA2465901C CA2465901C (en) 2010-10-26

Family

ID=23321557

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2465901A Expired - Fee Related CA2465901C (en) 2001-11-09 2002-11-08 Collapsible syringe cartridge

Country Status (22)

Country Link
US (1) US7011649B2 (en)
EP (1) EP1443992B1 (en)
JP (2) JP2005516646A (en)
KR (1) KR100877302B1 (en)
CN (1) CN100363063C (en)
AR (1) AR037306A1 (en)
AT (1) ATE350086T1 (en)
AU (1) AU2002352562B2 (en)
BR (1) BR0213991B1 (en)
CA (1) CA2465901C (en)
DE (1) DE60217382T2 (en)
DK (1) DK1443992T3 (en)
ES (1) ES2278992T3 (en)
HU (1) HU227056B1 (en)
IL (2) IL161336A0 (en)
MX (1) MXPA04004369A (en)
NO (1) NO333464B1 (en)
NZ (1) NZ532146A (en)
PT (1) PT1443992E (en)
TW (1) TW574045B (en)
WO (1) WO2003041770A2 (en)
ZA (1) ZA200404543B (en)

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