CA2469870A1 - High performance fluorescent optical sensor - Google Patents

High performance fluorescent optical sensor Download PDF

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Publication number
CA2469870A1
CA2469870A1 CA002469870A CA2469870A CA2469870A1 CA 2469870 A1 CA2469870 A1 CA 2469870A1 CA 002469870 A CA002469870 A CA 002469870A CA 2469870 A CA2469870 A CA 2469870A CA 2469870 A1 CA2469870 A1 CA 2469870A1
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CA
Canada
Prior art keywords
optical sensor
sensor device
light source
waveguide
light
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002469870A
Other languages
French (fr)
Other versions
CA2469870C (en
Inventor
Arthur E. Colvin, Jr.
Steven J. Walters
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sensors for Medicine and Science Inc
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2469870A1 publication Critical patent/CA2469870A1/en
Application granted granted Critical
Publication of CA2469870C publication Critical patent/CA2469870C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/064—Stray light conditioning
    • G01N2201/0642—Light traps; baffles

Abstract

An optical sensor device for determining the presence or concentration of an analyte, contains a waveguide (103) disposed over a light source (101) of a substrate (100) and separated by an internal baffle (104), wherein the waveguide has a thickness corresponding to a far field emission point of the light source as determined by a light shielding baffle between the light source and light detector.

Claims (20)

1. An optical sensor device for determining the presence or concentration of an analyte, comprising:
a substrate;
a light source for emitting light primarily of a preselected wavelength upon energization, mounted on a surface of said substrate;
a light detector for detecting light incident thereon and generating an electrical signal responsive thereto, mounted on said surface adjacent to said light source, and being separated therefrom by a light shielding baffle;
a waveguide formed over said light source and said light detector; said waveguide having a mean thickness corresponding to a far field emission point of said light source; and an analyte-permeable indicator matrix disposed on an outer surface of said waveguide, said indicator matrix containing light-emitting indicator molecules whose light emission is attenuated or enhanced by the presence of analyte in said matrix, said indicator molecule being selected such that the wavelength emitted by the light source excites light emission in the indicator molecules; wherein said light detector generates an electrical signal responsive to light incident thereon emitted by said indicator molecules.
2. An optical sensor device according to claim 1, wherein said outer surface of said waveguide is substantially flat, and the thickness of said waveguide corresponds to said far field emission point of said light source.
3. An optical sensor device according to claim 1, wherein said outer surface of said waveguide is in a curved arc configuration.
4. An optical sensor device according to claim 3, wherein a focal point of said curved arc is outside of said sensing device.
5. An optical sensor device according to claim 1, wherein undesired additional wavelengths emitted by said light source are caused to pass out of said waveguide without being substantially reflected thereby.
6. An optical sensor device according to claim 1, wherein said sensing device is used to detect at least two different analytes.
7. An optical sensor device according to claim 1, wherein said analyte-permeable indicator matrix is illuminated substantially solely by direct illumination from said light source.
8. An optical sensor device according to claim 1, wherein said light detector collects substantially solely direct fluorescence illumination from said indicator matrix.
9. An optical sensor device according to claim 1, wherein said light source is an LED.
10. An optical sensor device according to claim 1, wherein said light detector is a photodiode.
11. An optical sensor device according to claim 1, wherein said light-emitting indicator molecules are fluorescence molecules.
12. An optical sensor device according to claim 1, wherein said baffle defines at least two cavities in which said light source and said light detector are located when mounted on said substrate, and said waveguide is formed over said cavities.
13. An optical sensor device according to claim 12, further comprising a transparent fill-in material formed over said light source in the cavity in which said light source is located, wherein said transparent fill-in material has a refractive index that is substantially equal to the refractive index of said waveguide, such that said light source is in effect mounted within said waveguide.
14. An optical sensor device according to claim 12, further comprising a color-doped fill-in material formed over said light source in the cavity in which said light source is located, wherein said color-doped fill-in material has a color corresponding to a peak wavelength emission of said light source.
15. An optical sensor device according to claim 12, further comprising a color-doped fill-in material formed over said photodetector in the cavity in which said photodetector is located, wherein said color-doped fill-in material functions as a filter to block a predominant wavelength emitted by said light source from impinging on said photodetector.
16. An optical sensor device according to claim 13, wherein said fill-in material is a polymeric material.
17. An optical sensor device according to claim 14, wherein said fill-in material is a polymeric material.
18. An optical sensor device according to claim 15, wherein said fill-in material is a polymeric material.
19. An optical sensor device according to claim. l2, further comprising a fill-in material formed over said light source in the cavity in which said light source is located, wherein said fill-in material has a refractive index that is lower than the refractive index of said waveguide.
20. An optical sensor device according to claim 15, wherein said color-doped fill-in material has a refractive index that is higher than the refractive index of said waveguide.
CA2469870A 2001-12-11 2002-12-11 High performance fluorescent optical sensor Expired - Fee Related CA2469870C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33864701P 2001-12-11 2001-12-11
US60/338,647 2001-12-11
PCT/US2002/039675 WO2003050519A1 (en) 2001-12-11 2002-12-11 High performance fluorescent optical sensor

Publications (2)

Publication Number Publication Date
CA2469870A1 true CA2469870A1 (en) 2003-06-19
CA2469870C CA2469870C (en) 2011-07-26

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2469870A Expired - Fee Related CA2469870C (en) 2001-12-11 2002-12-11 High performance fluorescent optical sensor

Country Status (13)

Country Link
US (2) US6940590B2 (en)
EP (1) EP1454129B1 (en)
JP (1) JP4430396B2 (en)
CN (2) CN1602420B (en)
AT (1) ATE436011T1 (en)
AU (1) AU2002359673B2 (en)
BR (1) BR0214824A (en)
CA (1) CA2469870C (en)
DE (1) DE60232912D1 (en)
HK (2) HK1064442A1 (en)
MX (1) MXPA04005608A (en)
TW (1) TWI293363B (en)
WO (1) WO2003050519A1 (en)

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Also Published As

Publication number Publication date
US6940590B2 (en) 2005-09-06
CN101819149B (en) 2012-06-13
US20030156290A1 (en) 2003-08-21
HK1064442A1 (en) 2005-01-28
MXPA04005608A (en) 2004-12-06
CN101819149A (en) 2010-09-01
CN1602420B (en) 2010-05-26
CN1602420A (en) 2005-03-30
ATE436011T1 (en) 2009-07-15
JP2005513426A (en) 2005-05-12
JP4430396B2 (en) 2010-03-10
DE60232912D1 (en) 2009-08-20
EP1454129A1 (en) 2004-09-08
AU2002359673B2 (en) 2009-01-08
EP1454129B1 (en) 2009-07-08
WO2003050519A1 (en) 2003-06-19
AU2002359673A1 (en) 2003-06-23
CA2469870C (en) 2011-07-26
BR0214824A (en) 2004-09-14
TWI293363B (en) 2008-02-11
EP1454129A4 (en) 2006-08-02
US7190445B2 (en) 2007-03-13
TW200303984A (en) 2003-09-16
US20050237518A1 (en) 2005-10-27
HK1148067A1 (en) 2011-08-26

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