CA2474243A1 - Medical device for delivering biologically active material - Google Patents

Medical device for delivering biologically active material Download PDF

Info

Publication number
CA2474243A1
CA2474243A1 CA002474243A CA2474243A CA2474243A1 CA 2474243 A1 CA2474243 A1 CA 2474243A1 CA 002474243 A CA002474243 A CA 002474243A CA 2474243 A CA2474243 A CA 2474243A CA 2474243 A1 CA2474243 A1 CA 2474243A1
Authority
CA
Canada
Prior art keywords
medical device
biologically active
active material
struts
middle section
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002474243A
Other languages
French (fr)
Other versions
CA2474243C (en
Inventor
Arthur L. Rosenthal
William J. Shaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Ltd Bermuda
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2474243A1 publication Critical patent/CA2474243A1/en
Application granted granted Critical
Publication of CA2474243C publication Critical patent/CA2474243C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91525—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other within the whole structure different bands showing different meander characteristics, e.g. frequency or amplitude
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155—Adjacent bands being connected to each other
    • A61F2002/91575—Adjacent bands being connected to each other connected peak to trough
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body

Abstract

A medical device (10) for delivering a biologically active material into a body tissue, comprising struts (13) and optionally the biologically active material. In an embodiment, the medical device (10) comprises non-structural elements (14) integral with the struts (13). A method for designing such medical device are also disclosed. Another embodiment is a medical device having an outer surface comprising a middle section (44) and end sections (46). The end sections having a greater available surface area, greater affinity for or a greater amount of the biologically active material per uni t length of the outer surface than the middle section. The middle section may be covered with a barrier layer. Another embodiment is a medical device comprising a rectangular portion having a greater capacity for carrying a biologically active material per unit length of the outer surface. A method for delivering a biologically active material to a body tissue is also disclosed.

Claims (44)

1. A medical device for delivering a biologically active material to a body tissue of a patient in need of treatment, wherein the medical device comprises a plurality of struts and a plurality of non-structural elements integral with the struts, wherein the struts and the non-structural elements comprise the biologically active material.
2. The medical device of claim 1, wherein the non-structural elements project from the struts and are configured in a shape selected from the group consisting of a cone, a truncated cone, an oval, a straight rod, a bent rod, and a rod having heads at the ends.
3. The medical device of claim 1, wherein the non-structural elements are configured in a shape selected from the groups consisting of hoops, knots and bends, which are located along the stems.
4. The medical device of claim 1, which comprises a tubular portion comprising an outer surface, and wherein the non-structural elements are distributed throughout the outer surface.
5. The medical device of claim 1, which comprises a tubular portion comprising an outer surface, wherein the non-structural elements are located in a radially asymmetric distribution on the outer surface.
6. The medical device of claim 5, wherein the non-structural elements axe distributed in a rectangular portion of the outer surface.
7. The medical device of claim 6, wherein the rectangular portion is parallel to longitudinal axis of the tubular portion.
8. The medical device of claim 7, wherein the rectangular portion and the tubular portion have same length.
9. The medical device of claim 8, wherein the surface area of the rectangular portion is from about 25% to about 75 % of the entire surface area of the outer surface.
10. The medical device of claim 1, which comprises a tubular portion comprising an outer surface, wherein the outer surface has a middle section and end sections, and wherein the end sections comprise a greater number of the non-structural elements per unit length of the outer surface than the middle section.
11. The medical device of claim 1, wherein the biologically active material is selected from the group consisting of paclitaxel, actinomycin, sirolimus, tacrolimus, everolimus, dexamethasone, halofuginone and hydrophobic nitric oxide adducts.
12. The medical device of claim 1, the medical device is a stent.
13. A method for designing a medical device for delivering a biologically active material to a body tissue of a patient, wherein the medical device comprises a plurality of struts and a plurality of non-structural elements integral with the struts, wherein the struts and the non-structural elements comprise the biologically active material, wherein the method comprises:
(a) providing a preliminary medical device comprising a plurality struts in a geometric pattern wherein the struts comprise the biologically active material;
(b) determining a concentration-profile for the biologically active material which is released from the preliminary medical device; and (c) modifying the geometric pattern of the struts of the preliminary medical device by incorporating a plurality of non-functional elements comprising the biologically active material that are integral with the struts to achieve more desired distribution of the biologically active material in the body tissue.
14. The method of claim 13, wherein the biologically active material has a minimum effective concentration and a maximum effective concentration for the body tissue, and wherein steps (b) and (c) are repeated until the body tissue to be treated is substantially free from a concentration of the biologically active material that is smaller than the minimum effective concentration and a concentration of the biologically active material that is greater than the maximum effective concentration over a desired time period.
15. The method of claim 13, wherein the biologically active material is selected from the group consisting of paclitaxel, actinomycin, sirolimus, tacrolimus, everolimus, dexamethasone, halofuginone and hydrophobic nitric oxide adducts.
16. The method of claim 13, wherein the medical device is a scent.
17. A medical device insertable into the body of a patient, which comprises an outer surface comprising a plurality of struts, wherein the outer surface has a middle section and end sections, and wherein the end sections have a greater available surface area per unit length of the outer surface than the middle section.
18. The medical device of claim 17, wherein at least a part of each of the middle section and the end sections of the outer surface comprise the biologically active material.
19. The medical device of claim 17, wherein struts located at the end sections have a greater surface area by having a more porous surface than struts located at the middle section.
20. The medical device of claim 19, wherein the struts located at the end sections are comprised of a porous material and the struts located at the middle section is comprised of a less porous material.
21. The medical device of claim 20, wherein the struts located at the end sections are covered with the porous material, and the struts located at the middle section are covered with the less porous material.
22. The medical device of claim 17, wherein the average diameter of the struts located at the end sections is greater than the average diameter of the struts located at the middle section.
23. A medical device insertable into the body of a patient, which comprises an outer surface comprising a plurality of struts, wherein the outer surface has a middle section and end sections, and wherein the end sections a greater affinity for the biologically active material area per unit length of the outer surface than the middle section.
24. The medical device of claim 23, wherein at least a part of each of the middle section and the end sections of the outer surface comprise the biologically active material.
25. The medical device of claim 23, wherein the struts located at the end sections comprise a first matrix material and the struts located at the middle section comprise a second matrix material, and wherein the first matrix material has a greater affinity for the biologically active material than the second matrix material.
26. The medical device of claim 25, wherein the struts located at the end sections ire covered with a coating of the first matrix material and the struts located at the middle section are covered with a coating of the second matrix material.
27. The medical device of claim 25, wherein the end sections and middle section further comprise the biologically active material.
28. The medical device of claim 23, wherein at least a part of each of the middle section and the end sections are covered with a linking material, and wherein the struts located at the end sections comprise a greater amount of the linking material per unit length of the outer surface than the struts located at the middle section.
29. The medical device of claim 28, wherein the outer surface comprises the biologically active material which is linked to the linking material.
30. The medical device of claim 19, which the medical device is a stent.
31. A medical device insertable into the body of a patient, which comprises an outer surface, wherein the outer surface has a middle section and end sections, wherein at least a part of each of the middle section and the end sections is covered with a coating layer comprising a first biologically active material, and wherein the end sections carry or contain a larger amount of first biologically active material per unit length of the outer surface than the middle section.
32. The medical device of claim 31, wherein the medical device comprises a tubular portion that comprises the outer surface.
33. The medical device of claim 31, wherein the coating covering the end sections comprises a coating layer containing a, second biologically active material.
34. A medical device insertable into the body of a patient, which comprises an outer surface, wherein the outer surface has a middle section and end sections, wherein at least a part of each of the middle section and the end sections is covered with a coating comprising a first biologically active material, and the middle section comprises a barrier layer placed over the coating covering the middle section for reducing the release rate of the biologically active material.
35. The medical device of claim 34, wherein the medical device comprises a tubular portion and the outer surface is at least a part of the outer surface of the tubular portion.
36. The medical device of claim 35, wherein the medical device is a stent and the barrier layer is a sheath.
37. A medical device insertable into the body of a patient , which comprises an outer surface comprising a plurality of struts, wherein the outer surface has a rectangular portion having a greater capacity for carrying or containing a biologically active material per unit length of the outer surface than the parts of the outer surface that are outside the rectangular portion, by having a greater surface for carrying or having a greater affinity for the biologically active material than the parts of the outer surface that are outside the rectangular portion.
38. The medical device of claim 37, wherein the medical device comprises a tubular portion comprising the outer surface, and the rectangular portion is parallel to longitudinal axis of the tubular portion.
39. The medical device of claim 38, wherein the rectangular portion and the tubular portion have same length.
40. The medical device of claim 39, wherein a surface area of the rectangular portion is from about 25% to about 75 % of the outer surface.
41. The medical device of claim 37, wherein at least a portion of the outer surface comprises the biologically active material.
42. The medical device of claim 37, wherein the medical device is a stent
43. A method for delivering a biologically active material to body tissue of a patient in need of treatment which comprises inserting a medical device of claim 38 into body of the patient in such a way that the rectangular portion is in direct contact with the body tissue in need of treatment.
44. The method of claim 43, wherein the biologically active material is selected from the group consisting of paclitaxel, actinomycin, sirolimus, tacrolimus, everolimus, dexamethasone, halofuginone and hydrophobic nitric oxide adducts.
CA2474243A 2002-01-31 2003-01-30 Medical device for delivering biologically active material Expired - Fee Related CA2474243C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/062,794 US7291165B2 (en) 2002-01-31 2002-01-31 Medical device for delivering biologically active material
US10/062,794 2002-01-31
PCT/US2003/002585 WO2003063924A1 (en) 2002-01-31 2003-01-30 Medical device for delivering biologically active material

Publications (2)

Publication Number Publication Date
CA2474243A1 true CA2474243A1 (en) 2003-08-07
CA2474243C CA2474243C (en) 2012-07-24

Family

ID=27610351

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2474243A Expired - Fee Related CA2474243C (en) 2002-01-31 2003-01-30 Medical device for delivering biologically active material

Country Status (7)

Country Link
US (1) US7291165B2 (en)
EP (1) EP1485138A4 (en)
JP (1) JP2005523049A (en)
AU (1) AU2003219687B2 (en)
CA (1) CA2474243C (en)
NZ (1) NZ534508A (en)
WO (1) WO2003063924A1 (en)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774278B1 (en) * 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
US7846202B2 (en) * 1995-06-07 2010-12-07 Cook Incorporated Coated implantable medical device
US20070032853A1 (en) * 2002-03-27 2007-02-08 Hossainy Syed F 40-O-(2-hydroxy)ethyl-rapamycin coated stent
US7807211B2 (en) * 1999-09-03 2010-10-05 Advanced Cardiovascular Systems, Inc. Thermal treatment of an implantable medical device
US7682647B2 (en) 1999-09-03 2010-03-23 Advanced Cardiovascular Systems, Inc. Thermal treatment of a drug eluting implantable medical device
US8632845B2 (en) * 2000-12-28 2014-01-21 Abbott Cardiovascular Systems Inc. Method of drying bioabsorbable coating over stents
WO2002067653A2 (en) 2001-02-26 2002-09-06 Scimed Life Systems, Inc. Bifurcated stent and delivery system
US7771468B2 (en) 2001-03-16 2010-08-10 Angiotech Biocoatings Corp. Medicated stent having multi-layer polymer coating
US7326245B2 (en) * 2002-01-31 2008-02-05 Boston Scientific Scimed, Inc. Medical device for delivering biologically active material
US7445629B2 (en) * 2002-01-31 2008-11-04 Boston Scientific Scimed, Inc. Medical device for delivering biologically active material
US7709048B2 (en) * 2002-05-02 2010-05-04 Labcoat, Ltd. Method and apparatus for coating a medical device
US6645547B1 (en) 2002-05-02 2003-11-11 Labcoat Ltd. Stent coating device
US7169178B1 (en) * 2002-11-12 2007-01-30 Advanced Cardiovascular Systems, Inc. Stent with drug coating
US7491234B2 (en) * 2002-12-03 2009-02-17 Boston Scientific Scimed, Inc. Medical devices for delivery of therapeutic agents
US7942920B2 (en) 2003-02-25 2011-05-17 Cordis Corporation Stent with nested fingers for enhanced vessel coverage
US7918884B2 (en) 2003-02-25 2011-04-05 Cordis Corporation Stent for treatment of bifurcated lesions
US20040220656A1 (en) * 2003-04-30 2004-11-04 Epstein Samuel J. Coated medical devices and methods of making the same
US20080215137A1 (en) * 2003-04-30 2008-09-04 Boston Scientific Scimed, Inc. Therapeutic driving layer for a medical device
US7279174B2 (en) * 2003-05-08 2007-10-09 Advanced Cardiovascular Systems, Inc. Stent coatings comprising hydrophilic additives
CA2525631C (en) * 2003-05-13 2012-12-18 Medtronic, Inc. Moisture curable materials for delivery of agents, methods, and medical devices
US20050118344A1 (en) * 2003-12-01 2005-06-02 Pacetti Stephen D. Temperature controlled crimping
US7056337B2 (en) * 2003-10-21 2006-06-06 Cook Incorporated Natural tissue stent
EP1699527A1 (en) 2004-01-02 2006-09-13 Advanced Cardiovascular Systems, Inc. High-density lipoprotein coated medical devices
US7537781B2 (en) * 2004-02-12 2009-05-26 Boston Scientific Scimed, Inc. Polymer-filler composites for controlled delivery of therapeutic agents from medical articles
US20050181015A1 (en) * 2004-02-12 2005-08-18 Sheng-Ping (Samuel) Zhong Layered silicate nanoparticles for controlled delivery of therapeutic agents from medical articles
US20050214339A1 (en) 2004-03-29 2005-09-29 Yiwen Tang Biologically degradable compositions for medical applications
US8118864B1 (en) * 2004-05-25 2012-02-21 Endovascular Technologies, Inc. Drug delivery endovascular graft
US20050287184A1 (en) * 2004-06-29 2005-12-29 Hossainy Syed F A Drug-delivery stent formulations for restenosis and vulnerable plaque
US20060034884A1 (en) * 2004-08-10 2006-02-16 Stenzel Eric B Coated medical device having an increased coating surface area
US20060134168A1 (en) 2004-12-07 2006-06-22 Chappa Ralph A Coatings with crystallized active agent(s) and methods
US20060129225A1 (en) * 2004-12-15 2006-06-15 Kopia Gregory A Device for the delivery of a cardioprotective agent to ischemic reperfused myocardium
US8535702B2 (en) * 2005-02-01 2013-09-17 Boston Scientific Scimed, Inc. Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility
US8221824B2 (en) * 2005-02-03 2012-07-17 Boston Scientific Scimed, Inc. Deforming surface of drug eluting coating to alter drug release profile of a medical device
US7998195B2 (en) * 2005-03-25 2011-08-16 Boston Scientific Scimed, Inc. Device with engineered surface architecture coating for controlled drug release
US20060235499A1 (en) * 2005-04-14 2006-10-19 Cardiac Pacemakers, Inc. Coated lead fixation electrode
US7477946B2 (en) * 2005-04-26 2009-01-13 Cardiac Pacemakers, Inc. Fixation device for coronary venous lead
US8175724B2 (en) * 2005-04-26 2012-05-08 Cardiac Pacemakers, Inc. Vascular fixation device
US20070020312A1 (en) * 2005-07-20 2007-01-25 Desnoyer Jessica R Method of fabricating a bioactive agent-releasing implantable medical device
US8439964B2 (en) * 2005-08-23 2013-05-14 Boston Scientific Scimed, Inc. Stent with web-inducing nodes for increased surface area
US20070055352A1 (en) * 2005-09-07 2007-03-08 Wendy Naimark Stent with pockets for containing a therapeutic agent
US20070073385A1 (en) * 2005-09-20 2007-03-29 Cook Incorporated Eluting, implantable medical device
US20070208415A1 (en) * 2006-03-06 2007-09-06 Kevin Grotheim Bifurcated stent with controlled drug delivery
US8216267B2 (en) 2006-09-12 2012-07-10 Boston Scientific Scimed, Inc. Multilayer balloon for bifurcated stent delivery and methods of making and using the same
US8883190B2 (en) * 2006-12-01 2014-11-11 Wake Forest University Health Sciences Urologic devices incorporating collagen inhibitors
US8000810B2 (en) * 2007-03-20 2011-08-16 Cardiac Pacemakers, Inc. Systems and methods for transvenous lead implantation
US8961589B2 (en) * 2007-08-01 2015-02-24 Abbott Cardiovascular Systems Inc. Bioabsorbable coating with tunable hydrophobicity
US8142490B2 (en) * 2007-10-24 2012-03-27 Cordis Corporation Stent segments axially connected by thin film
US7863387B2 (en) * 2007-10-25 2011-01-04 Boston Scientific Scimed, Inc. Dehydrofluorination and surface modification of fluoropolymers for drug delivery applications
ES2371380T3 (en) * 2008-01-24 2011-12-30 Boston Scientific Scimed, Inc. STENT TO SUPPLY A THERAPEUTIC AGENT FROM A SIDE SURFACE OF A STENT STEM.
US20090198321A1 (en) * 2008-02-01 2009-08-06 Boston Scientific Scimed, Inc. Drug-Coated Medical Devices for Differential Drug Release
US8048171B2 (en) * 2008-03-27 2011-11-01 Boston Scientific Scimed, Inc. Ureteral stents for release of urologically beneficial agents
US8932340B2 (en) 2008-05-29 2015-01-13 Boston Scientific Scimed, Inc. Bifurcated stent and delivery system
US9220818B2 (en) * 2008-07-23 2015-12-29 Boston Scientific Scimed, Inc. Medical devices having inorganic barrier coatings
US20100057187A1 (en) * 2008-08-26 2010-03-04 Caldarise Salvatore G Intravascular stent having imrproved design for loading and deploying
US8257722B2 (en) 2008-09-15 2012-09-04 Cv Ingenuity Corp. Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
US9198968B2 (en) 2008-09-15 2015-12-01 The Spectranetics Corporation Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
US8128951B2 (en) 2008-09-15 2012-03-06 Cv Ingenuity Corp. Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
US8114429B2 (en) 2008-09-15 2012-02-14 Cv Ingenuity Corp. Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens
US8888840B2 (en) * 2009-05-20 2014-11-18 Boston Scientific Scimed, Inc. Drug eluting medical implant
US9309347B2 (en) 2009-05-20 2016-04-12 Biomedical, Inc. Bioresorbable thermoset polyester/urethane elastomers
US20110319987A1 (en) 2009-05-20 2011-12-29 Arsenal Medical Medical implant
US9265633B2 (en) 2009-05-20 2016-02-23 480 Biomedical, Inc. Drug-eluting medical implants
EP2432425B1 (en) 2009-05-20 2018-08-08 480 Biomedical, Inc. Medical implant
US8992601B2 (en) 2009-05-20 2015-03-31 480 Biomedical, Inc. Medical implants
US8372133B2 (en) 2009-10-05 2013-02-12 480 Biomedical, Inc. Polymeric implant delivery system
US9320890B2 (en) * 2009-11-09 2016-04-26 W. L. Gore & Associates, Inc. Drug eluting composite
CN101926697B (en) * 2010-07-13 2013-05-22 北京迈迪顶峰医疗科技有限公司 Outflow track expandable stent and conveyor thereof
US9220584B2 (en) 2012-03-30 2015-12-29 Abbott Cardiovascular Systems Inc. Treatment of diabetic patients with a stent and locally administered adjunctive therapy
US9956385B2 (en) 2012-06-28 2018-05-01 The Spectranetics Corporation Post-processing of a medical device to control morphology and mechanical properties
US10525171B2 (en) 2014-01-24 2020-01-07 The Spectranetics Corporation Coatings for medical devices
EP2994175A1 (en) 2014-02-04 2016-03-16 Abbott Cardiovascular Systems, Inc. Drug delivery scaffold or stent with a novolimus and lactide based coating such that novolimus has a minimum amount of bonding to the coating
KR102432918B1 (en) * 2019-03-25 2022-08-17 연세대학교 산학협력단 Fibrosis-induced drug-eluting stent

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4728328A (en) 1984-10-19 1988-03-01 Research Corporation Cuffed tubular organic prostheses
US6004346A (en) 1990-02-28 1999-12-21 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5064435A (en) 1990-06-28 1991-11-12 Schneider (Usa) Inc. Self-expanding prosthesis having stable axial length
US5643309A (en) * 1993-03-25 1997-07-01 Myler; Richard Cardiovascular stent and retrieval apparatus
US6087479A (en) 1993-09-17 2000-07-11 Nitromed, Inc. Localized use of nitric oxide-adducts to prevent internal tissue damage
JP2825452B2 (en) 1994-04-25 1998-11-18 アドヴァンスド カーディオヴァスキュラー システムズ インコーポレーテッド Radiopak stent marker
ATE310839T1 (en) 1994-04-29 2005-12-15 Scimed Life Systems Inc STENT WITH COLLAGEN
JP3640690B2 (en) * 1994-10-03 2005-04-20 株式会社ニデック Intraocular lens
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US5667523A (en) 1995-04-28 1997-09-16 Impra, Inc. Dual supported intraluminal graft
US5609629A (en) * 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
AU716005B2 (en) 1995-06-07 2000-02-17 Cook Medical Technologies Llc Implantable medical device
GB9522332D0 (en) * 1995-11-01 1996-01-03 Biocompatibles Ltd Braided stent
AR001162A1 (en) * 1996-03-06 1997-09-24 Parodi Juan C Non-migratory positioning endovascular expander
US5824045A (en) 1996-10-21 1998-10-20 Inflow Dynamics Inc. Vascular and endoluminal stents
EP0934036B1 (en) * 1996-10-28 2004-03-03 BIOTRONIK Mess- und Therapiegeräte GmbH & Co Ingenieurbüro Berlin Stent
US6197013B1 (en) 1996-11-06 2001-03-06 Setagon, Inc. Method and apparatus for drug and gene delivery
US5827321A (en) 1997-02-07 1998-10-27 Cornerstone Devices, Inc. Non-Foreshortening intraluminal prosthesis
KR100526913B1 (en) 1997-02-20 2005-11-09 쿡 인코포레이티드 Coated implantable medical device
US5817126A (en) 1997-03-17 1998-10-06 Surface Genesis, Inc. Compound stent
US5824054A (en) * 1997-03-18 1998-10-20 Endotex Interventional Systems, Inc. Coiled sheet graft stent and methods of making and use
US6048360A (en) 1997-03-18 2000-04-11 Endotex Interventional Systems, Inc. Methods of making and using coiled sheet graft for single and bifurcated lumens
US5843172A (en) 1997-04-15 1998-12-01 Advanced Cardiovascular Systems, Inc. Porous medicated stent
US6273913B1 (en) * 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
US5746691A (en) 1997-06-06 1998-05-05 Global Therapeutics, Inc. Method for polishing surgical stents
US5972027A (en) * 1997-09-30 1999-10-26 Scimed Life Systems, Inc Porous stent drug delivery system
US6165209A (en) * 1997-12-15 2000-12-26 Prolifix Medical, Inc. Vascular stent for reduction of restenosis
US5976169A (en) * 1997-12-16 1999-11-02 Cardiovasc, Inc. Stent with silver coating and method
US6241762B1 (en) * 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US6110100A (en) * 1998-04-22 2000-08-29 Scimed Life Systems, Inc. System for stress relieving the heart muscle and for controlling heart function
JP4583597B2 (en) 1998-05-05 2010-11-17 ボストン サイエンティフィック リミテッド Smooth end stent
US6192271B1 (en) 1999-04-20 2001-02-20 Michael Hayman Radiotherapy stent
US6287628B1 (en) 1999-09-03 2001-09-11 Advanced Cardiovascular Systems, Inc. Porous prosthesis and a method of depositing substances into the pores
DE69934990T2 (en) 1999-11-23 2007-11-15 Sorin Biomedica Cardio S.R.L., Saluggia Method of transferring radioactive substances to stents in angioplasty and kit
US6471979B2 (en) 1999-12-29 2002-10-29 Estrogen Vascular Technology, Llc Apparatus and method for delivering compounds to a living organism
EP1132058A1 (en) * 2000-03-06 2001-09-12 Advanced Laser Applications Holding S.A. Intravascular prothesis
US6451050B1 (en) 2000-04-28 2002-09-17 Cardiovasc, Inc. Stent graft and method
US6254632B1 (en) * 2000-09-28 2001-07-03 Advanced Cardiovascular Systems, Inc. Implantable medical device having protruding surface structures for drug delivery and cover attachment
US6764507B2 (en) * 2000-10-16 2004-07-20 Conor Medsystems, Inc. Expandable medical device with improved spatial distribution
US6506437B1 (en) * 2000-10-17 2003-01-14 Advanced Cardiovascular Systems, Inc. Methods of coating an implantable device having depots formed in a surface thereof
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US6964680B2 (en) * 2001-02-05 2005-11-15 Conor Medsystems, Inc. Expandable medical device with tapered hinge
DE10107795B4 (en) 2001-02-13 2014-05-15 Berlex Ag Vascular support with a basic body, method for producing the vascular support, apparatus for coating the vascular support
US6540777B2 (en) * 2001-02-15 2003-04-01 Scimed Life Systems, Inc. Locking stent
US20030069630A1 (en) * 2001-03-02 2003-04-10 Robert Burgermeister Stent with radiopaque markers incorporated thereon
US6764505B1 (en) 2001-04-12 2004-07-20 Advanced Cardiovascular Systems, Inc. Variable surface area stent
AU2002327219B2 (en) * 2001-07-06 2009-04-23 Syntach Ag Anti-arrhythmia devices and methods of use
US6517889B1 (en) 2001-11-26 2003-02-11 Swaminathan Jayaraman Process for coating a surface of a stent
US7014654B2 (en) * 2001-11-30 2006-03-21 Scimed Life Systems, Inc. Stent designed for the delivery of therapeutic substance or other agents
US6981985B2 (en) * 2002-01-22 2006-01-03 Boston Scientific Scimed, Inc. Stent bumper struts
EP1348402A1 (en) * 2002-03-29 2003-10-01 Advanced Laser Applications Holding S.A. Intraluminal endoprosthesis, radially expandable, perforated for drug delivery
US20050230039A1 (en) * 2004-04-19 2005-10-20 Michael Austin Stent with protective pads or bulges

Also Published As

Publication number Publication date
EP1485138A4 (en) 2007-08-29
US20030144727A1 (en) 2003-07-31
JP2005523049A (en) 2005-08-04
NZ534508A (en) 2006-07-28
WO2003063924A1 (en) 2003-08-07
US7291165B2 (en) 2007-11-06
AU2003219687B2 (en) 2008-04-03
CA2474243C (en) 2012-07-24
EP1485138A1 (en) 2004-12-15

Similar Documents

Publication Publication Date Title
CA2474243A1 (en) Medical device for delivering biologically active material
JP2005523049A5 (en)
WO2006053159A3 (en) Medical device for delivering biologically active material
US8177743B2 (en) Localized delivery of drug agents
US6939320B2 (en) Localized delivery of drug agents
US7326245B2 (en) Medical device for delivering biologically active material
EP1079872B1 (en) Localized delivery of drug agents
US7628807B2 (en) Stent for delivering a therapeutic agent having increased body tissue contact surface
US8048149B2 (en) Intraluminal stent including therapeutic agent delivery pads, and method of manufacturing the same
DE69825162T2 (en) INTRAVASCULAR STENT WITH A DEFLECTION DEVICE
AU2003219687A1 (en) Medical device for delivering biologically active material
US20060025848A1 (en) Medical device having a coating layer with structural elements therein and method of making the same
US20050049695A1 (en) System for delivering a coated medical implant
CA2472638A1 (en) Stent bumper struts
EP1527756A3 (en) Stent aneurysm treatment system and method
WO1998007387B1 (en) Stent delivery system with storage sleeve
EP1428547A3 (en) A wire-stranded hollow coil body, medical equipment made therefrom and a method of making the same
EP0688197A1 (en) Resilient prosthesis for widening a channel, particularly a blood vessel, and method for making same
EP2033667A3 (en) Porous medicated stent
KR100439156B1 (en) Covering composition for drug releasing stent and method of preparing same
EP2563287B1 (en) Drug eluting folded stent and stent delivery system
EP2327380A1 (en) Stent having functional elements
US20100106234A1 (en) Medical Devices With Extended Drug Diffusion Pathway
JP2005160600A (en) Liquid impregnating stent and liquid medication impregnating stent

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20140130

MKLA Lapsed

Effective date: 20140130