CA2475595A1

CA2475595A1 - Method of reducing and preventing uvb-induced immunosuppression

Info

Publication number: CA2475595A1
Application number: CA002475595A
Authority: CA
Inventors: Richard L. Miller; Joseph A. Gillis; Anthony A. Gaspari
Original assignee: Individual
Current assignee: 3M Innovative Properties Co
Priority date: 2002-02-22
Filing date: 2003-02-20
Publication date: 2003-09-04
Anticipated expiration: 2023-02-20
Also published as: ZA200407605B; AU2003213125A1; ES2541132T3; US20060142235A1; WO2003072026A3; EP1478327A4; HUE025145T2; SI1478327T1; DK1478327T3; NZ534566A; US20030161797A1; EP1478327B1; AU2003213125B2; PT1478327E; JP2005518433A; CA2475595C; WO2003072026A2; US7030129B2; BR0307788A; MXPA04008023A

Abstract

Methods of preventing and/or treating UV-induced immunosuppression by administration of immune response modifier compounds are disclosed herein. Suitable immune response modifier compounds include agonists of one or more TLRs.

Claims

1. A method of reducing UV-induced immunosuppression comprising administering to a treatment area an immune response modifier compound in an amount effective to inhibit UV-induced immunosuppression.

2. The method of claim 1 wherein administration of the immune response modifier compound occurs prior to exposure of the treatment area to UV irradiation.

3. The method of claim 1 wherein the immune response modifier compound is an agonist of at least one TLR.

4. The method of claim 3 wherein the immune response modifier compound is an agonist of TLR7, TLR8, or TLR9.

5. The method of claim 1 wherein the immune response modifier compound comprises an imidazoquinoline amine, an imidazopyridine amine, a 6,7-fused cycloalkylimidazopyridine amine, a 1,2.-bridged imidazoquinoline amine, an imidazonaphthyridine amine, an imidazotetrahydronaphthyridine amine, an oxazoloquinoline amine, a thiazoloquinoline amine, an oxazolopyridine amine, a thiazolopyridine amine, an oxazolonaphthyridine amine, or a thiazolonaphthyridine amine.

6. The method of claim 1 wherein the immune response modifier compound is administered via a topical application vehicle.

7. The method of claim 6 wherein the topical application vehicle comprises a cream, a gel, a spray, an ointment, a lotion, a solution, a suspension, an emulsion, a paste, a powder, or an oil.

8. The method of claim 6 wherein the immune response modifier compound is administered via a sunscreen, a skin lotion, a skin moisturizer, a cosmetic, a soap, a spray, a foam, a gel, or a surfactant-containing cleaning preparation.

9. A method of treating UV-induced immunosuppression comprising administering to a treatment area an immune response modifier in an amount effective to inhibit UV-induced immunosuppression.

10. The method of claim 9 wherein administration of the immune response modifier compound occurs prior to exposure of the treatment area to UV irradiation.

11. The method of claim 9 wherein the immune response modifier compound is an agonist of at least one TLR.

12. The method of claim 11 wherein the immune response modifier compound is an agonist of TLR7, TLR8, or TLR9.

13. The method of claim 9 wherein the immune response modifier compound comprises an imidazoquinoline amine, an imidazopyridine amine, a 6,7-fused cycloalkylimidazopyridine amine, a 1,2-bridged imidazoquinoline amine, an imidazonaphthyridine amine, an imidazotetrahydronaphthyridine amine, an oxazoloquinoline amine, a thiazoloquinoline amine, an oxazolopyridine amine, a thiazolopyridine amine, an oxazolonaphthyridine amine, or a thiazolonaphthyridine amine.

14. The method of claim 9 wherein the immune response modifier compound is administered via a topical application vehicle.

15. The method of claim 14 wherein the topical application vehicle comprises a cream, a gel, a spray, an ointment, a lotion, a solution, a suspension, an emulsion, a paste, a powder, or an oil.

16. The method of claim 14 wherein the immune response modifier compound is administered via a sunscreen, a skin lotion, a skin moisturizer, a cosmetic, a soap, a spray, a foam, a gel, or a surfactant-containing cleaning preparation.