CA2476076A1 - Injector with bypass channel - Google Patents

Injector with bypass channel Download PDF

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Publication number
CA2476076A1
CA2476076A1 CA002476076A CA2476076A CA2476076A1 CA 2476076 A1 CA2476076 A1 CA 2476076A1 CA 002476076 A CA002476076 A CA 002476076A CA 2476076 A CA2476076 A CA 2476076A CA 2476076 A1 CA2476076 A1 CA 2476076A1
Authority
CA
Canada
Prior art keywords
substance
injector
stopper
cartridge
channel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002476076A
Other languages
French (fr)
Other versions
CA2476076C (en
Inventor
Paul R. Lesch, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Antares Pharma Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2476076A1 publication Critical patent/CA2476076A1/en
Application granted granted Critical
Publication of CA2476076C publication Critical patent/CA2476076C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M2005/2006—Having specific accessories
    • A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2459—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
    • A61M2005/2462—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst by displacing occluding plugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/286—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
    • A61M2005/287—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst by displacing occluding plugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • A61M2005/3132—Syringe barrels having flow passages for injection agents at the distal end of the barrel to bypass a sealing stopper after its displacement to this end due to internal pressure increase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2459—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/286—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
    • A61M5/321—Means for protection against accidental injuries by used needles
    • A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
    • A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

An injector with a substance container defining a substance chamber (43) configured for containing a substance to be injected, and an injection condu it configured for injecting the substance into a patient. A driver is associate d with the substance chamber (43) for driving the substance through the injection conduit. The injector also has a channel member defining a channel (74) that has an open configuration in which the channel fluidly communicate d the substance container to the injection conduit for injection of the substance (44).

Claims (28)

1. An injector, comprising:
a substance container defining a substance chamber configured for containing a substance to be injected;
an injection conduit configured for injecting the substance into a patient;
a driver associated with the substance chamber for driving the substance through the injection conduit;
a channel member defining a channel fluidly communicating the substance container to the injection conduit for injecting the substance;
a blocking stopper having a closed position for blocking flow of any substance from the substance container through the channel to the injection conduit, the blocking stopper being movable to an open position for fluidly communicating the channel with the substance container for injecting the substance; and a firing mechanism operably associated with the driver and operable by the user to cause the driver to drive the substance sufficiently to move the blocking stopper to the open position and also to inject the substance into the patient.
2. The injector of claim 1, wherein the firing mechanism is operable by the user to cause the driver to drive the substance sufficiently to move the blocking stopper to the open position and also to inject the substance into the patient by a single action of the user on the firing mechanism.
3. The injector of claim 1, wherein the injector is assembled such that actuation of the firing mechanism to cause the substance to be injected also causes the blocking stopper to move to the open position.
4. The injector of claim 1, further comprising an energy source configured for driving the driver to both move the blocking stopper to the open position and inject the substance into the patient.
5. The injector of claim 4, wherein the firing mechanism comprises a trigger mechanism activatable by the user, wherein a single activation of the trigger activates the energy source for moving the blocking stopper to the open position and also to inject the substance into the patient.
6. The injector of claim 1, wherein the injector is fully assembled and in condition for firing the substance with the blocking stopper in the closed position.
7. The injector of claim 1, wherein substantially all of the substance to be injected is disposed between the driver and the blocking stopper.
8. The injector of claim 7, wherein the driver comprises a plunger, and both the plunger and the blocking stopper are slideable within the container.
9. The injector of claim 1, wherein the substance container has a distal end disposed adjacent the injection conduit, and the channel member is disposed in or adjacent the distal end.
10. The injector of claim 1, wherein the injection conduit comprises a needle.
11. The injector of claim 1, wherein the injection conduit comprises a needle-free jet nozzle configured for firing the substance in a fluid jet sufficient to penetrate tissue of the patient.
12. The injector of claim 1, further comprising a delivery conduit configured for delivering the substance from the container to the injection conduit, wherein the channel is defined in the delivery conduit and has a substance entryway that is blocked by the blocking stopper in the closed position and unblocked thereby in the open position.
13. The injector of claim 1, further comprising a delivery conduit configured for delivering the substance from the container to the injection conduit, wherein the channel is defined in the blocking stopper, and the delivery conduit comprises a protrusion received in the channel to close the channel when the blocking stopper is in the closed position, and removed therefrom when the blocking stopper is in the open position.
14. The injector of claim 1, further comprising:
a resilient cartridge-gripping portion engaged with the cartridge to retain the cartridge sealed and in fluid communication with the injection conduit during injection; and a locking portion in contact with the cartridge gripping portion to retain the cartridge-gripping portion in the engagement with the cartridge to withstand pressures within the cartridge during injection.
15. The injector of claim 1, wherein the substance container comprises a shoulder to stop movement of the driver towards the blocking stopper prior to moving into contact herewith.
16. An injector, comprising:
a substance container defining a substance chamber configured for containing a substance to be injected;
an injection conduit configured for injecting the substance into a patient;
a driver associated with the substance chamber for driving the substance through the injection conduit;
a channel member defining a channel that has an open configuration in which the channel fluidly communicates the substance container to the injection conduit for injecting the substance;
a blocking stopper positioned downstream of any substance to be injected that is contained in the container, the blocking stopper being movable with respect to the channel between closed and open positions, in the closed position the stopper closing the channel for sealing and retaining the substance within the cartridge, and in the open position the stopper cooperating with the channel to allow the substance to move past the stopper, through the channel and to the injection conduit; and a firing mechanism operably associated with the driver and operable by the user to cause the driver to drive the substance sufficiently to move the blocking stopper to the open position and also to inject the substance into the patient.
17. The injector of claim 16, wherein the substance container has a distal end adjacent the injection conduit, and the stopper is disposed in the distal end, the open position of the stopper being disposed in a first direction closer to the injection conduit than the closed position, and the channel having a substance exit for delivering the substance to the injection conduit and located in the first direction from the substance entryway.
18. The injector of claim 17, wherein the container comprises a cartridge that includes said distal end, the stopper being disposed in the distal end in the open position and outside the cartridge in the open position.
19. The injector of claim 16, wherein the channel comprises a groove along an interior surface of the channel member, wherein a first end of the groove comprises the entryway.
20. The injector of claim 16, wherein:
the injection conduit comprises a needle having an upstream opening for receiving the substance during injection thereof; and the blocking stopper is configured to move to the open position without the needle piercing the stopper.
21. The injector of claim 16, wherein the second side of the blocking stopper is configured for receiving the needle in the open position, the stopper defining an internal groove configured and dimensioned for allowing the substance to flow therethrough to the upstream opening of the needle in the open position.
22. The injector of claim 16, wherein the channel member comprises a guide protruding towards the interior of the channel member for guiding and positioning the stopper in the open position.
23. The injector of claim 16, wherein the channel member comprises a narrow portion configured for blocking movement of the blocking stopper past the open position.
24. The injector of claim 16, wherein the stopper has a first side facing inside the cartridge and a second side facing the outside the cartridge, in the closed position, the stopper closing the channel for sealing and retaining the substance within the cartridge adjacent the first side of the stopper such that the second side of the stopper is free from contact with any of the substance from the cartridge.
25. An injector, comprising:
a cartridge configured and dimensioned for containing a substance to be injected;
an injection conduit configured for injecting the substance into a patient;
a driver associated with the substance chamber for pressurizing and driving the substance through the injection conduit;
a resilient cartridge-gripping portion engaged with the cartridge to retain the cartridge sealed and in fluid communication with the injection conduit during injection; and a locking portion in contact with the cartridge gripping portion to retain the cartridge-gripping portion in the engagement with the cartridge to withstand pressures within the cartridge during injection.
26. The injector of claim 25, wherein:
the cartridge comprises a first end that defines a locking recess;
the cartridge-gripping portion comprises a plurality of resilient fingers that are received in the locking recess; and the locking portion is disposed around the fingers for retaining the fingers engaged in the locking recess.
27. The injector of claim 25, wherein the pressure within the cartridge during injection is about between 50 psi and 3000 psi.
28. A method of injecting a substance into a patient, comprising:
providing an injector with a blocking stopper in a closed position blocking all substance to be injected from a channel; and activating a trigger mechanism of the injector by a single action of a user to move a driver with an energy source to bias the substance both for moving the blocking member to open the channel and for injecting the substance through the open channel and an injection conduit of the injector into a patient.
CA2476076A 2002-02-15 2003-02-14 Injector with bypass channel Expired - Fee Related CA2476076C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35723602P 2002-02-15 2002-02-15
US60/357,236 2002-02-15
PCT/US2003/004382 WO2003070296A2 (en) 2002-02-15 2003-02-14 Injector with bypass channel

Publications (2)

Publication Number Publication Date
CA2476076A1 true CA2476076A1 (en) 2003-08-28
CA2476076C CA2476076C (en) 2012-03-27

Family

ID=27757589

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2476076A Expired - Fee Related CA2476076C (en) 2002-02-15 2003-02-14 Injector with bypass channel

Country Status (9)

Country Link
US (1) US7488308B2 (en)
EP (1) EP1476211B1 (en)
JP (1) JP2005517500A (en)
KR (1) KR20040096561A (en)
AU (1) AU2003217404A1 (en)
BR (1) BR0307677A (en)
CA (1) CA2476076C (en)
ES (1) ES2547444T3 (en)
WO (1) WO2003070296A2 (en)

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CA2476076C (en) 2012-03-27
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WO2003070296A2 (en) 2003-08-28
AU2003217404A1 (en) 2003-09-09
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AU2003217404A8 (en) 2003-09-09
EP1476211A2 (en) 2004-11-17
KR20040096561A (en) 2004-11-16
EP1476211A4 (en) 2011-01-05
US20050020984A1 (en) 2005-01-27
ES2547444T3 (en) 2015-10-06
BR0307677A (en) 2005-01-11

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