CA2481711A1 - Method and device for selective separation of a compound from a body fluid - Google Patents

Method and device for selective separation of a compound from a body fluid Download PDF

Info

Publication number
CA2481711A1
CA2481711A1 CA002481711A CA2481711A CA2481711A1 CA 2481711 A1 CA2481711 A1 CA 2481711A1 CA 002481711 A CA002481711 A CA 002481711A CA 2481711 A CA2481711 A CA 2481711A CA 2481711 A1 CA2481711 A1 CA 2481711A1
Authority
CA
Canada
Prior art keywords
acid
polymer
functional group
matrix
body fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002481711A
Other languages
French (fr)
Other versions
CA2481711C (en
Inventor
Bo Johnson
Lennart Ljunggren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alteco Medical AB
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA002680643A priority Critical patent/CA2680643A1/en
Publication of CA2481711A1 publication Critical patent/CA2481711A1/en
Application granted granted Critical
Publication of CA2481711C publication Critical patent/CA2481711C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28054—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their surface properties or porosity
    • B01J20/28078—Pore diameter
    • B01J20/28085—Pore diameter being more than 50 nm, i.e. macropores
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/14—Other self-supporting filtering material ; Other filtering material
    • B01D39/16—Other self-supporting filtering material ; Other filtering material of organic material, e.g. synthetic fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/14—Other self-supporting filtering material ; Other filtering material
    • B01D39/20—Other self-supporting filtering material ; Other filtering material of inorganic material, e.g. asbestos paper, metallic filtering material of non-woven wires
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3204—Inorganic carriers, supports or substrates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/321—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3251—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising at least two different types of heteroatoms selected from nitrogen, oxygen or sulphur
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B01J20/3246—Non-macromolecular compounds having a well defined chemical structure
    • B01J20/3248—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such
    • B01J20/3255—Non-macromolecular compounds having a well defined chemical structure the functional group or the linking, spacer or anchoring group as a whole comprising at least one type of heteroatom selected from a nitrogen, oxygen or sulfur, these atoms not being part of the carrier as such comprising a cyclic structure containing at least one of the heteroatoms nitrogen, oxygen or sulfur, e.g. heterocyclic or heteroaromatic structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • C—CHEMISTRY; METALLURGY
    • C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
    • C02F1/00—Treatment of water, waste water, or sewage
    • C02F1/38—Treatment of water, waste water, or sewage by centrifugal separation

Abstract

The invention refers to method for selectively binding and separating at least one component from whole blood or a body fluid, whereby the blood or body fluid is allowed to pass through a rigid integral separation matrix without being excluded therefrom. The matrix has a porous structure with a pore size ranging from 5 micron to 500 micron as well as active surface ranging from 0.5 cm2 to 10 m2, and the surface is able to bind such components.

Claims (22)

1. A method for selectively binding and separating at least one component from whole blood or a body fluid, wherein said blood or body fluid is allowed to pass through a rigid integral separation matrix without being excluded therefrom, said matrix having a porous structure with a pore size ranging from 5 micron to 500 micron as well as an active surface ranging from 0.5 cm2 to 10 m2, which is able to bind said at least one component.
2. The method as in claim 1, wherein said matrix further comprises at least one functional group that has been introduced by means of coating and/or surface modification of said porous structure, said at least one functional group alone or in combination with non-functionalized regions of said porous structure being able to bind said at least one component.
3. The method as in claim 1, wherein said matrix is made of a metal, inorganic oxide, carbon, glass, a ceramic, a synthetic polymer, and/or a natural polymer, or mixtures thereof.
4. The method as in claim 3, wherein said metal is magnetic.
5. The method as in claim 3 or 4, wherein said synthetic or natural polymer has been coated onto said metal, high surface area inorganic oxide, carbon, glass, ceramic, synthetic polymer, and/or natural polymer, or mixtures thereof.
6. The method as in claim 3 or 5, wherein said synthetic polymer is a polyolefine, a vinylic polymer, a fluorine containing polymer, a polyacrylate, a polyamide, a polyimide, a polyimine, a polystyrene and its copolymers, a silicone rubber, a polyester, a polycarbonate, a poly-uretane, a poly sulfonate, a polyglycol, a polyether, or a polyalkydoxide, or a copolymer or a hybrid thereof.
7. The method as in claim 3 or 5, wherein said natural polymer is a polysaccharide, a polycarbohydrate, a polyamino acid, a polylactic acid, or a polyglycolic acid, or a copolymer or a hybrid thereof.
8. The method as in claim 2, wherein said surface modification has been accomplished by means of electro-deposition, electroevaporation, plasma chemical deposition, deposition from an ion plasma flow, plasma polymerization, plasma enhanced surface polymer deposition, or chemical vapor deposition.
9. The method as in claim 1, wherein said porous structure has been obtained by means of sintering, extrusion, moulding, or foaming processes.
10. The method as in claim 2, wherein said at least one functional group is a sulfhydryl, a carboxylate, an amine, an aldehyde, a ketone, a hydroxyl, a halogen, a hydrazide, or an active hydrogen.
11. The method as in claim 2, wherein a ligand has been coupled to said at least one functional group in a covalent way.
12. The method as in claim 11, wherein said ligand is a protein, a peptide, an antibody or a fragment thereof, a carbohydrate, a polysaccharide, a hormone, an antioxidant, a glycoprotein, a lipoprotein, a lipid, a fat soluble vitamin, a bile acid, a reactive dye, allantoin, uric acid, or polymyxin, or combinations thereof.
13. The method as in claim 11 or 12, wherein a cross-linker has been covalently coupled between said at least one functional group and said ligand.
14. The method as in claim 13, wherein said cross-linker is a homobifunctional, a heterobifunctional, or a trifunctional crosslinker.
15. The method as in claim 13 or 14, wherein said crosslinker has been covalently coupled as a spacer between said at least one functional group and said ligand.
16. The method as in claim 15, wherein said spacer is a silane, a diisocyanate, a glycolate, a polyethylene-glycol, a succinimidyl reagent, a dihydrazine, adipicd, a diamine, an amino acid, an oligoamino acid, a polyamino acid, a peptide, or a protein.
17. The method as in claim 1, wherein said separation matrix has the shape of a disk, a rod, a cylinder, a ring, a sphere, a tube, or a hollow tube.
18. The method as in any of claims 1-17, which is carried out in a device (1) comprising a housing (2), an inlet (3), an outlet (4), and said at least one separation matrix ( 5a, 5b, ...).
19. The method as in claim 18, wherein said device has several separation matrixes (5a, 5b,...), each select-ively and separately removing at least one component from whole blood or a body fluid.
20. The method as in claim 18 or 19, wherein the flow rate through said device is ranging from 5 ml/h to 6 000 ml/min.
21. Use of a bile acid moiety immobilized on a support for eliminating a component from an aqueous solution comprising the same.
22. The use as in claim 21, wherein said bile acid moiety is a deoxycholic acid moiety.
CA2481711A 2002-04-25 2003-04-04 Method and device for selective separation of a compound from a body fluid Expired - Lifetime CA2481711C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002680643A CA2680643A1 (en) 2002-04-25 2003-04-04 Method and device for selectively eliminating a component from an aqueous solution

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0201257-3 2002-04-25
SE0201257A SE0201257D0 (en) 2002-04-25 2002-04-25 Improved Separation
PCT/SE2003/000553 WO2003090924A1 (en) 2002-04-25 2003-04-04 Improved separation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002680643A Division CA2680643A1 (en) 2002-04-25 2003-04-04 Method and device for selectively eliminating a component from an aqueous solution

Publications (2)

Publication Number Publication Date
CA2481711A1 true CA2481711A1 (en) 2003-11-06
CA2481711C CA2481711C (en) 2011-09-20

Family

ID=20287687

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2481711A Expired - Lifetime CA2481711C (en) 2002-04-25 2003-04-04 Method and device for selective separation of a compound from a body fluid
CA002680643A Abandoned CA2680643A1 (en) 2002-04-25 2003-04-04 Method and device for selectively eliminating a component from an aqueous solution

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA002680643A Abandoned CA2680643A1 (en) 2002-04-25 2003-04-04 Method and device for selectively eliminating a component from an aqueous solution

Country Status (16)

Country Link
US (3) US20030231981A1 (en)
EP (2) EP1497025B1 (en)
JP (4) JP2006508703A (en)
KR (2) KR100950432B1 (en)
CN (2) CN101049522B (en)
AT (1) ATE329687T1 (en)
AU (1) AU2003217134C1 (en)
BR (1) BR0309349A (en)
CA (2) CA2481711C (en)
DE (2) DE60306135T2 (en)
ES (2) ES2328386T3 (en)
HK (2) HK1081138A1 (en)
MX (1) MXPA04010543A (en)
RU (2) RU2311183C2 (en)
SE (1) SE0201257D0 (en)
WO (1) WO2003090924A1 (en)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1723233B1 (en) * 2004-03-05 2012-04-18 SIRS-Lab GmbH Method for enriching and/or separating prokaryotic dna using a protein that specifically bonds to unmethylated dna containing cpg-motives
WO2006025371A1 (en) * 2004-08-30 2006-03-09 Kaneka Corporation Granulocyte adsorbent
WO2006025556A1 (en) * 2004-08-31 2006-03-09 Showa Denko K.K. Surface-modified packing material for liquid chromatography and production method thereof
GB2420976B (en) * 2004-11-19 2006-12-20 Zvi Finkelstein Therapeutic implant
DE102004062535A1 (en) * 2004-12-24 2006-07-06 Forschungszentrum Karlsruhe Gmbh Semipermeable membrane system for magnetic particle fractions
JP4821466B2 (en) * 2006-07-03 2011-11-24 富士ゼロックス株式会社 Droplet discharge head
US8165663B2 (en) * 2007-10-03 2012-04-24 The Invention Science Fund I, Llc Vasculature and lymphatic system imaging and ablation
WO2009039378A2 (en) * 2007-09-19 2009-03-26 The Charles Stark Draper Laboratory, Inc. Microfluidic structures for biomedical applications
US8285366B2 (en) * 2007-10-04 2012-10-09 The Invention Science Fund I, Llc Vasculature and lymphatic system imaging and ablation associated with a local bypass
US8285367B2 (en) * 2007-10-05 2012-10-09 The Invention Science Fund I, Llc Vasculature and lymphatic system imaging and ablation associated with a reservoir
US7790803B2 (en) * 2008-06-02 2010-09-07 Uop Llc Crosslinked organic-inorganic hybrid membranes and their use in gas separation
US8758324B2 (en) 2010-03-05 2014-06-24 The Invention Science Fund I, Llc Device for actively removing a target cell from blood or lymph of a vertebrate subject
US8246565B2 (en) 2009-02-25 2012-08-21 The Invention Science Fund I, Llc Device for passively removing a target component from blood or lymph of a vertebrate subject
US8317737B2 (en) 2009-02-25 2012-11-27 The Invention Science Fund I, Llc Device for actively removing a target component from blood or lymph of a vertebrate subject
US8454547B2 (en) 2009-02-25 2013-06-04 The Invention Science Fund I, Llc Device, system, and method for controllably reducing inflammatory mediators in a subject
DE102009034150A1 (en) 2009-07-20 2011-01-27 Fresenius Medical Care Deutschland Gmbh Adsorbent for the adsorption of hepcidin
AT509192B1 (en) * 2010-06-24 2011-07-15 Zentrum Fuer Biomedizinische Technologie Der Donau Uni Krems SORPTION FOR ENDOTOXINES
WO2012154218A2 (en) * 2011-05-09 2012-11-15 The University Of Miami Reducing soluble urokinase receptor in the circulation
CN102441363A (en) * 2011-09-28 2012-05-09 南开大学 Adsorbent used for clearing cancer cells in blood
GB201203546D0 (en) * 2012-02-29 2012-04-11 Whatman Gmbh Membrane filter and a method of manufacturing the same
KR102067445B1 (en) * 2012-05-31 2020-01-17 에이전시 포 사이언스, 테크놀로지 앤드 리서치 Methods for reducing levels of protein-contaminant complexes and aggregates in protein preparations by treatment with electropositive organic additives
CN104619388B (en) 2012-05-31 2016-06-22 新加坡科技研究局 The selective binding of biological target and solid phase uride
EP2679302A1 (en) 2012-06-28 2014-01-01 Zentrum für biomedizinische Technologie der Donau- Universität Krems Selective sorption agent for extracorporeal blood purification
KR101427700B1 (en) * 2012-06-29 2014-08-07 주식회사 아모그린텍 Cytokine Adsorbent Sheet, Manufacturing Method Thereof and Blood Filter using The same
JP2014061284A (en) * 2012-08-31 2014-04-10 Asahi Kasei Medical Co Ltd Base material and device for suppressing organ inflammation
JP5592450B2 (en) * 2012-09-18 2014-09-17 大日精化工業株式会社 Self-propelled cell trap
WO2014059323A1 (en) * 2012-10-12 2014-04-17 Advantageous Systems Llc Immobilization of particles on a matrix
DE102012020615A1 (en) * 2012-10-19 2014-04-24 Hydac Filtertechnik Gmbh Process for the surface treatment of a filter medium
RU2537860C2 (en) * 2013-01-09 2015-01-10 Федеральное государственное бюджетное учреждение науки Институт металлоорганической химии им. Г.А. Разуваева Российской академии наук (ИМХ РАН) Photopolymerising composition for single-stage obtaining of polymer nanoporous material with hydrophobic surface of pores, nanoporous polymer material with selective sorptive properties, method of obtaining thereof, method of its obtaining, method of single-stage formation of water-separating filtering elements on its basis and method of purification of organic liquids from water
CN103303997B (en) * 2013-06-14 2015-04-22 湖北大学 Use of magnetic solid-phase extraction agent in treatment of dye wastewater
JP6648009B2 (en) * 2013-06-24 2020-02-14 エクステラ・メディカル・コーポレーション Blood filtration system containing mannose-coated substrate
US11680080B2 (en) 2014-03-13 2023-06-20 Folim G. Halaka Purification columns and methods
EP3117208A4 (en) * 2014-03-13 2018-01-24 Folim G. Halaka Purification columns and methods
US10905818B2 (en) * 2014-03-31 2021-02-02 Zoll Medical Corporation Blood filtering of inflammatory biomarkers to treat post-resuscitation syndrome
WO2016040850A1 (en) * 2014-09-11 2016-03-17 Oregon State University Microfluidic device for removal of constituents from blood
CN107073192B (en) * 2014-09-29 2019-08-09 旭化成医疗株式会社 Hollow fiber membrane type blood purifier
US11911551B2 (en) 2016-03-02 2024-02-27 Exthera Medical Corporation Method for treating drug intoxication
WO2017151797A1 (en) * 2016-03-02 2017-09-08 Exthera Medical Corporation Method for treating drug intoxication
CA3034065C (en) * 2016-08-18 2021-07-27 Asahi Kasei Medical Co., Ltd. Filter element for blood processing filter, blood processing filter and leukocyte removal method
JP7309470B2 (en) 2018-07-02 2023-07-18 旭化成メディカル株式会社 blood treatment beads
WO2020009008A1 (en) * 2018-07-02 2020-01-09 旭化成メディカル株式会社 Beads for blood processing
WO2020018005A1 (en) * 2018-07-17 2020-01-23 Limited Liability Company "Gero" Devices, methods, compositions and systems for the treatment of aging and age- related disorders
DE102018121552A1 (en) * 2018-09-04 2020-03-05 Karl Leibinger Medizintechnik Gmbh & Co. Kg Laser sintered filter, method for manufacturing the filter and method for liquid transport
CN110824157B (en) * 2019-11-14 2023-03-31 广州科方生物技术股份有限公司 Method for quickly separating red blood cells for immunochromatography detection kit
WO2022071849A1 (en) 2020-10-01 2022-04-07 Alteco Medical Ab Matrices for selective binding of at least one component from a body fluid
RU2765188C1 (en) * 2020-11-03 2022-01-26 Федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации Method for producing a selective sorbent for solid-phase extraction
AU2021386427A1 (en) * 2020-11-30 2023-07-20 Alteco Medical Ab Device for binding and separation of at least one component from a body fluid
CN112755973B (en) * 2020-12-16 2023-03-10 重庆天外天生物技术有限公司 Composite adsorption material applied to blood purification field and preparation method thereof

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3994799A (en) * 1973-04-17 1976-11-30 Yao Shang J Blood and tissue detoxification apparatus
JPS5434341U (en) * 1977-08-10 1979-03-06
JPS5714357A (en) * 1980-06-30 1982-01-25 Asahi Chemical Ind Catching material for lymphocyte
US4433059A (en) * 1981-09-08 1984-02-21 Ortho Diagnostic Systems Inc. Double antibody conjugate
CA1221307A (en) * 1982-12-02 1987-05-05 Nobutaka Tani Adsorbent and process for preparing the same
US4656254A (en) * 1985-12-02 1987-04-07 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor and antithrombin III
DE3617672C2 (en) * 1986-05-26 2000-02-17 Claus Heuck Process for the preparation of a reagent, a reagent produced according to it and its use for binding polymers and microorganisms from aqueous solutions
WO1989003885A1 (en) * 1987-10-27 1989-05-05 Centocor, Inc. Method of removing endotoxin contaminants
JPH0622633B2 (en) 1987-10-30 1994-03-30 鐘淵化学工業株式会社 Adsorbent and removal device using the same
JPH0246858A (en) * 1988-08-08 1990-02-16 Terumo Corp Body liquid treating device
US5153166A (en) * 1988-08-18 1992-10-06 Trustees Of At Biochem Chromatographic stationary supports
US5476715A (en) * 1989-10-03 1995-12-19 Fresenius Ag Particulate adsorbent for the removal of biomacromolecules such as LDL and endotoxins from whole blood in extracorporeal circuits
DE3932971C2 (en) * 1989-10-03 2003-03-13 Fresenius Ag Adsorbent suitable for the elimination of biomacromolecules, especially LDL and endotoxins, from whole blood in an extracorporeal circuit
EP0640351A1 (en) * 1993-07-26 1995-03-01 Duphar International Research B.V Method for the separtion of bacterial lipopolysaccharides from protein-containing solutions
ATA159993A (en) * 1993-08-10 1995-09-15 Dieter Dr Falkenhagen ARRANGEMENT FOR ELIMINATING SUBSTANCES FROM LIQUIDS
CA2127605A1 (en) * 1993-12-23 1995-06-24 Peter J. Degen Affinity separation method
JP3615785B2 (en) * 1994-04-28 2005-02-02 テルモ株式会社 HIV and related material removal materials
EP0747106A4 (en) * 1994-12-27 1999-07-07 Yuugengaisya Mikazuki Bunkakai Porous ceramic filter, method of manufacturing the same, extrusion molding die for manufacturing the same, and extrusion molding machine using the same
JPH1076004A (en) * 1996-09-05 1998-03-24 Kanegafuchi Chem Ind Co Ltd Adsorbing material for humor treatment and adsorber for humor treatment
US6616623B1 (en) * 1997-07-02 2003-09-09 Idializa Ltd. System for correction of a biological fluid
US6416487B1 (en) 1997-07-30 2002-07-09 Renal Tech International Llc Method of removing beta-2 microglobulin from blood
US6022477A (en) * 1997-11-14 2000-02-08 New Jersey Institute Of Technology Method and apparatus for isolation purification of biomolecules
JP3635654B2 (en) * 1997-12-26 2005-04-06 ニプロ株式会社 Blood component collection device
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
SE9901825D0 (en) * 1999-05-20 1999-05-20 Amersham Pharm Biotech Ab Foamed material filled with inner material
CN2385290Y (en) * 1999-07-07 2000-06-28 海尔集团公司 Plate type air heat-exchanger
US6774102B1 (en) 1999-09-29 2004-08-10 Gambro Dialysatoren Gmbh & Co. Kg Extracorporeal endotoxin removal method
US6866783B2 (en) * 2000-03-07 2005-03-15 Mat Adsorption Technologies Gmbh & Co. Kg Module with membrane elements in cross-flow and in a dead-end arrangement
JP2001276212A (en) * 2000-03-30 2001-10-09 Terumo Corp Method and circuit for blood component collection
US6497675B1 (en) * 2000-04-17 2002-12-24 Renal Tech International Llc Device for extracorporeal treatment of physiological fluids of organism
JP2001321365A (en) * 2000-05-16 2001-11-20 Fuji Photo Film Co Ltd Plasma or serum taking tool
JP2001347116A (en) * 2000-06-09 2001-12-18 Asahi Medical Co Ltd White blood cell removing filter device
JP2002173433A (en) * 2000-12-04 2002-06-21 Terumo Corp Method for preparing blood preparation from which leukocyte is removed and blood set
US6408894B1 (en) 2001-04-25 2002-06-25 Renaltech International, Llc Method of producing devices for blood purification
WO2007145579A1 (en) * 2006-06-16 2007-12-21 Biotech Igg Ab An adsorption device

Also Published As

Publication number Publication date
EP1497025B1 (en) 2006-06-14
JP2016120333A (en) 2016-07-07
EP1497025A1 (en) 2005-01-19
CN101049522A (en) 2007-10-10
US7601134B2 (en) 2009-10-13
US20070068870A1 (en) 2007-03-29
AU2003217134C1 (en) 2008-07-03
DE60328541D1 (en) 2009-09-03
HK1111369A1 (en) 2008-08-08
BR0309349A (en) 2005-03-01
ES2266797T3 (en) 2007-03-01
JP2011083632A (en) 2011-04-28
JP2006508703A (en) 2006-03-16
MXPA04010543A (en) 2005-01-25
AU2003217134A1 (en) 2003-11-10
US20080203021A1 (en) 2008-08-28
DE60306135D1 (en) 2006-07-27
CN1308068C (en) 2007-04-04
HK1081138A1 (en) 2006-05-12
US20030231981A1 (en) 2003-12-18
DE60306135T2 (en) 2007-04-19
JP2014111203A (en) 2014-06-19
CA2481711C (en) 2011-09-20
RU2007110420A (en) 2008-09-27
EP1704880A3 (en) 2006-10-04
KR20040104615A (en) 2004-12-10
RU2311183C2 (en) 2007-11-27
KR20080044359A (en) 2008-05-20
ES2328386T3 (en) 2009-11-12
EP1704880B1 (en) 2009-07-22
ATE329687T1 (en) 2006-07-15
SE0201257D0 (en) 2002-04-25
RU2004134345A (en) 2005-05-27
WO2003090924A1 (en) 2003-11-06
KR100950432B1 (en) 2010-04-02
CA2680643A1 (en) 2003-11-06
AU2003217134B2 (en) 2007-12-13
EP1704880A2 (en) 2006-09-27
RU2429902C2 (en) 2011-09-27
CN1649667A (en) 2005-08-03
CN101049522B (en) 2016-02-03
US7910002B2 (en) 2011-03-22

Similar Documents

Publication Publication Date Title
CA2481711A1 (en) Method and device for selective separation of a compound from a body fluid
JP2006508703A5 (en)
EP0806475B1 (en) Method of separating cells from blood
Hester et al. Design and performance of foul-resistant poly (vinylidene fluoride) membranes prepared in a single-step by surface segregation
US5939314A (en) Distributed pore chemistry in porous organic polymers in tissue culture flasks
US8673151B2 (en) Method of modifying surface of material
Shi et al. Poly (pyrrole-3-carboxylic acid)-alumina composite membrane for affinity adsorption of bilirubin
WO2019218898A1 (en) Crosslinked protein-based separation membrane and application thereof
EP3013462A1 (en) Porous nanomembranes
Piskin Plasma processing of biomaterials
CA2578202A1 (en) Fractionation apparatus
CN109688972B (en) Biocompatible and hemocompatible material and filter
AU2008201015B2 (en) Improved separation
CN115318251B (en) Adsorption composite microsphere and preparation method thereof
JP2010235496A (en) Immunoglobulin g separator
Ge et al. An albumin-fixed membrane for the removal of protein-bound toxins
Kim et al. Synthesis and Engineering of Polymeric Latex Particles for Hemodialysis Part I—A Review

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20230404