CA2482655C - Substituted indoles - Google Patents

Substituted indoles Download PDF

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CA2482655C
CA2482655C CA2482655A CA2482655A CA2482655C CA 2482655 C CA2482655 C CA 2482655C CA 2482655 A CA2482655 A CA 2482655A CA 2482655 A CA2482655 A CA 2482655A CA 2482655 C CA2482655 C CA 2482655C
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indol
propyl
carbonitrile
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compound
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CA2482655A1 (en
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Oliver Schadt
Henning Boettcher
Joachim Leibrock
Kai Schiemann
Timo Heinrich
Guenter Hoelzemann
Christoph Van Amsterdam
Gerd Bartoszyk
Christoph Seyfried
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Merck Patent GmbH
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Merck Patent GmbH
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Abstract

The invention relates to a compound of formula Ia, (see formula Ia) or a pharmaceutically usable salt, solvate or stereoisomer or a mixture thereof in which R1, R12, R13, D-E, X1, X2, Y, Z, p and r are as defined therein. These substituted indoles and their physiologically safe derivatives and salts have particular effects on the central nervous system, above all, effects that inhibit 5HT-resumption and 5HTx-agonistic and/or antagonistic effects and, in particular, serotonin, agonistic and antagonistic properties, and can be used as antipsychotics, antidepressants, anxiolytics and/or antihypertensives. These compositions can also be used as excitatory amino acid antagonists for fighting neurodegenerative diseases including cerebrovascular diseases, epilepsy, schizophrenia, Alzheimer's disease, Parkinson's disease or Huntington's disease, cerebral ischemias, infarcts or psychoses.

Description

Substituted indoles The invention relates to substituted indoles of the formula I

D\ X'~ G

(R12)P

in which R1 is H,AorSO2A, A is straight-chain or branched alkyl having from 1 to 10 carbon atoms, alkenyl having from 2 to 10 carbon atoms or alkoxy-alkyl having from 2 to 10 carbon atoms, and D-E is R2C=CR4 or R2R3C-CR4R5, in which R2, R3, R4 and R5 are selected, independently, from H, A, cycloalkyl having from 3 to 7 carbon atoms, Hal, CH2HaI, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)nN(R6)2, (CH2)nN(R6)Ar, (CH2)nN(R6)Het, (CH2)nN(Ar)2, (CH2)nN(Het)2, (CH2)n000R6, (CH2)n000Ar, (CH2)n000Het, (CH2)nCON(R6)2, (CH2)nCON(R6)Ar, (CH2)nCON(R6)Het, (CH2)nCON(Ar)2, (CH2)nCON(Het)2, (CH2)nNR6COR6, (CH2)nNR6CON(R6)2, (CH2)nNR6SO2A, (CH2)nSO2N(R6)2, (CH2)nSO2NR6(CH2)mAr, (CH2)nSO2NR6(CH2)mHet, (CH2)nS(O),R6, (CH2)nS(O),NAr, (CH2)nS(O),NHet, (CH2)n000R6, (CH2)nHet, (CH2)nAr, (CH2)nCOR6, (CH2)nCO(CH2)mAr, (CH2)nCO(CH2)mHet, (CH2)n000(CH2)mAr, (CH2)nCOO(CH2)mHet, (CH2)nOR6, (CH2)nO(CH2)mAr, (CH2)nO(CH2)mHet, (CH2)nSR6, (CH2)nS(CH2)mAr, (CH2)nS(CH2)mHet, (CH2)nN(R6)(CH2)mAr, (CH2)nN(R6)(CH2)mHet, (CH2)nSO2N(R6)(CH2)mAr, (CH2)nN(R6)SO2(CH2)mAr, (CH2)nSO2N(R6)(CH2)mHet, (CH2)nN(R6)SO2(CH2)mHet, (CH2)nCON(R6)(CH2)mAr, (CH2)nN(R6)CO(CH2)mAr, (CH2)nCON(R6)(CH2)mHet, (CH2)nN(R6)CO(CH2)mHet, CH=N-OA, CH2CH=N-OA, (CH2)nNHOA, (CH2)nCH=N-Het, (CH2)n000R6, (CH2)nOC(O)N(R6)2, (CH2)nOC(O)NR6(CH2)mAr, (CH2)nOC(O)NR6(CH2)mHet, (CH2)nNR6000R6, (CH2)nNR6000(CH2)mAr, (CH2)nNR 6COO(CH2)mHet, (CH2)nN(R6)CH2CH20R6, (CH2)nN(R)CH2CH2OCF3, (CH2)nN(R6)C(R6)H000R6, (CH2)nN(R6)CH2COHet, (CH2)nN(R6)CH2Het, (CH2)nN(R6)CH2CH2N(R6)CH2OOOR6, (CH2)nN(R6)CH2CH2N(R6)2, CH=CHCOOR6, CH=CHCH2NR6Het, CH=CHCH2N(R6)2, CH=CHCH2OR6, (CH2)nN(000R6)COOR6, (CH2)nN(CON H2)000R6, (CH2)nN(CONH2)CONH2, (CH2)nN(CH2OOOR)COOR6, (CH2)nN(CH2CONH2)000R6, (CH2)nN(CH2CONH2)CONH2, (CH2)nCHR6COR6, (CH2)nCHR6000R6, (CH2)nCHR6CH20R6, (CH2)nOCN or (CH2)nNCO, in which R6 is selected, independently, from H, A or cycloalkyl having from 3 to 7 carbon atoms, Het is a saturated, unsaturated or aromatic mono- or bicyclic heterocyclic radical which is unsubstituted or mono- or poly-substituted by A, Hal, NO2, CN, OR6, N(R6)2, COOR6, CON(R6)2, NR6COR6, NR6CON(R6)2, NR6SO2A, COR 6, S02N(R6)2, S(O)WA and/or OOCR6, Ar is an aromatic hydrocarbon radical having from 6 to 14 car-bon atoms which is unsubstituted or mono- or polysubstituted by A, Hal, NO2, ORE, N(R6)2, COOR6, CON(R6)2, NR6COR6, NR6CON(R6)2, NR'SO2A, COR 6, SO2N(R6)2, S(O),,A and/or OOCR6, w is 0, 1, 2 or 3, and n and m, independently of one another, are 0, 1, 2, 3, 4 or 5;
X1 is (CHR7)9 or (CHR7)h-Q-(CHR8)k, in which Q is selected from 0, S, N-R6, (O-CHR7)9, (CHR'-O),, CR9=CR1 , (O-CHR9CHR1 )9, (CHR9CHR1 -O)9, C=O, C=S, C=NR6, CH(ORE), C(OR6)(OR6), C(=O)O, OC(=O), OC(=O)O, C(=O)N(R6), N(R6)C(=O), C(=S)N(R6), N(R6)C(=S), OC(=O)N(R6), N(R6)C(=O)O, CH=N-O, CH=N-NR6, OC(O)NR6, NR6C(O)O, S=O, SO2, SO2NR6 and NR6SO2, g is 1, 2,3,4,5 or 6, h and k, independently of one another, are 0, 1, 2, 3, 4, 5 or 6, and R', R8, R9, R10 and R12 are selected, independently, from the mean-ings indicated for R2 to R5;

p is 0, 1, 2 or 3 E is H, A, (CH2)nHet, (CH2)nAr or cycloalkyl having from 3 to 7 carbon atoms, G is an optionally substituted alkylene radical having from 1 to 4 carbon atoms, where the substituents are selected from the meanings indicated for R4, or E and G, together with the N atom to which they are bonded, are an unsubstituted or substituted 5-, 6- or 7-membered, mono- or bicyclic heterocyclic radical, which may have 1, 2 or 3 further heteroatoms selected from N, 0 and S, X2 is a bond or is selected, independently, from the meanings indicated for X1, Z is H or is a saturated, mono- or polyethylenically unsaturated or aromatic carbocyclic radical having from 5 to 10 carbon atoms or a saturated, mono- or polyethylenically unsaturated or aromatic heterocyclic radical having from 4 to 9 carbon atoms, where the carbocyclic or heterocyclic radical may be mono- or polysubstituted, where the substituents are selected, independently of one another, from the meanings of R2 to R5 other than H, and where the heterocyclic radical contains from 1 to 4 heteroatoms selected, independently of one another, from N, 0 and S, and Hal is F, Cl, Br or I, and salts and solvates thereof, preferably physiologically tolerated salts and solvates thereof and in particular physiologically tolerated salts thereof.

Benzylpiperidine derivatives with high affinity to binding sites of amino acid receptors are disclosed, for example, in EP 0 709 384 Al.

The invention had the object of finding novel compounds having valuable properties, in particular those which have an improved action profile, for example higher activity, higher selectivity or a broader use profile and/or less severe side effects. It should preferably be possible to prepare the novel compounds simply and inexpensively, and they should be, in par-ticular, suitable for the preparation of medicaments.

Surprisingly, it has been found that the object is achieved by the com-pounds of the formula I. In particular, it has been found that the com-pounds of the formula I and salts thereof have very valuable pharmacol-ogical properties as well as being well tolerated.

The compounds according to the invention exhibit particular actions on the central nervous system, especially 5HT reuptake-inhibiting and 5HTx-ago-nistic and/or -antagonistic actions, where HTx is preferably taken to mean HT1A, HT1o, HT2A and/or HT2C.

Since the compounds inhibit serotonin reuptake, they are particularly suit-able as antipsychotics, neuroleptics, antidepressants, anxiolytics and/or antihypertonics. The compounds exhibit serotonin-agonistic and -antago-nistic properties. They inhibit the binding of tritiated serotonin ligands to hippocampal receptors (Cossery et al., European J. Pharmacol. 140 (1987), 143-155) and synaptosomal serotonin reuptake (Sherman et al., Life Sci. 23 (1978) , 1863-1870). In addition, changes in DOPA accu-mulation in the striatum and 5-HT accumulation in various regions of the brain occur (Seyfried et at., European J. Pharmacol. 160 (1989), 31-41).
The 5-HT1A-antagonistic action is detected in vitro, for example, by inhibi-tion of the abolition of electrically induced contraction of the guinea pig ileum caused by 8-OH-DPAT (Fozard and Kilbinger, Br. J. Pharmacol. 86 (1985) 601 P). The 5-HT1A-antagonistic action is detected ex vivo by inhibi-tion of 5-HTP accumulation reduced by 8-OH-DPAT (Seyfried et at., Euro-pean J. Pharmacol. 160 (1989), 31-41) and the antagonisation of 8-OH-DPAT-induced effects in the ultrasound vocalisation test (DeVry, Psych-pharmacol. 121 (1995), 1-26). Inhibition of serotonin reuptake can be detected ex vivo using synaptosomal uptake inhibition (Wong et at., Neuropsychopharmacol. 8 (1993), 23-33) and p-chloroamphetamine antagonism (Fuller et al., J. Pharmacol. Exp. Ther. 212 (1980), 115-119).
Furthermore, analgesic and hypotensive actions occur.

The compounds are therefore suitable for the treatment of schizophrenia, cognitive deficits, anxiety, depression, nausea, tardive dyskinesia, gastro-intestinal tract disorders, learning disorders, age-related memory dis-orders, psychoses and for positively influencing obsessive-compulsive disorder (OCD) and eating disorders (for example bulimia). They exhibit actions on the central nervous system, in particular additional 5-HT1A-ago-nistic and 5-HT reuptake-inhibiting actions. They are likewise suitable for the prophylaxis of and combating the consequences of cerebral infarction (apoplexia cerebri), such as strokes and cerebral ischaemia, and for the treatment of extrapyramidal motor side effects of neuroleptics and of Parkinson's disease.

The compounds of the formula I are therefore suitable both in veterinary and in human medicine for the treatment of dysfunctions of the central nervous system and of inflammation. They can be used for the prophylaxis of and for combating the consequences of cerebral infarction (apoplexia cerebri), such as strokes and cerebral ischaemia, and for the treatment of extrapyramidal motor side effects of neuroleptics and of Parkinson's dis-ease, for the acute and symptomatic therapy of Alzheimer's disease and for the treatment of amyotrophic lateral sclerosis. They are likewise suit-able as therapeutic agents for the treatment of brain and spinal cord trauma. However, they are also suitable as medicament active ingredients for anxiolytics, antidepressants, antipsychotics, neuroleptics, antihyper-tonics and/or for positively influencing obsessive-compulsive disorder, sleeping disorders, tardive dyskinesia, learning disorders, age-related memory disorders, eating disorders, such as bulimia, and/or sexual dys-functions.

The compounds according to the invention particularly preferably exhibit high bioavailability and/or are capable of significantly increasing the sero-tonin level in the brain.

The present invention therefore relates to compounds according to the invention as medicament or medicament active ingredient.

The present invention therefore relates to the use of the compounds according to the invention for the preparation of a medicament for the pro-phylaxis and/or therapy of diseases in which 5HT plays a role.

These diseases are preferably selected from depression, strokes, cerebral ischaemia, extrapyramidal motor side effects of neuroleptics and of Park-inson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, brain and spinal cord trauma, obsessive-compulsive disorder, sleeping dis-orders, tardive dyskinesia, learning disorders, age-related memory dis-orders, eating disorders, such as bulimia, and/or sexual dysfunctions.
Furthermore, the compounds according to the invention preferably exhibit particularly high affinity to binding sites of amino acid receptors, in par-ticular to the ifenprodil binding site on the NMDA receptor (NMDA = N-methyl D-aspartate), which allosterically modulates the polyamine binding site.

The binding test for [3H]-ifenprodil can be carried out by the method of Schoemaker et al., Eur. J. Pharmacol. 176, 249-250 (1990).
The compounds are suitable for the treatment of neurodegenerative dis-eases, including cerebrovascular diseases. The novel compounds can likewise be used as analgesicsor anxiolytic and for the treatment of epi-lepsy, schizophrenia, Alzheimer's disease, Parkinson's disease, Hunting-ton's disease, cerebral ischaemia or infarction. They are furthermore suit-able for the treatment of psychoses caused by excessively high amino acid levels.

The [3H]-CGP-39653 binding test for the glutamate binding site of the NMDA receptor can be carried out, for example, by the method of M.A.
Stills et al., described in Eur. J. Pharmacol. 192, 19-24 (1991). The test for the glycine binding site of the NMDA receptor can be carried out by the method of M.B. Baron et al., described in Eur. J. Pharmacol. 206, 149-154 (1991).

The action against Parkinson's disease, i.e. potentiation of the L-DOPA-induced contralateral rotation in hemiparkinsonian rats, can be demon-strated by the method of U. Ungerstedt and G.W. Arbuthnott, Brain Res.
24, 485 (1970).

The compound is particularly suitable for the treatment or prophylaxis of strokes and for protection against and for the treatment of cerebral oedema and states of undersupply of the central nervous system, in par-ticular hypoxia or anoxia.

The said effects can in addition be demonstrated or checked by the meth-ods as described in the following references:
J.W. McDonald, F.S. Silverstein and M.V. Johnston, Eur. J. Pharmacol.
140, 359 (1987); R. Gill, A.C. Foster and G.N. Woodruff, J. Neurosci. 7, 3343 (1987); J.B. Bederson et al., Stroke, 17, 472-476 (1986); S. Brint et al., J. Cereb. Blood Flow Metab. 8, 474-485 (1988).

The references listed below disclose various antagonists which are able to block various binding sites of the NMDA receptor:
W. Danysz, C.G. Parsons, I. Bresink and G. Quack, Drug, News & Per-spectives 8, 261 (1995), K.R. Gee, Exp. Opin. Invest. Drugs 3, 1021 (1994) and J.J. Kulagowski and L.L. Iversen, J. Med. Chem. 37, 4053 (1994).

Ifenprodil and eliprodil of the formulae IV and V respectively are able to block the NMDA receptor by interacting with the modulatory polyamine binding site (C.J. Carter, K.G. Lloyd, B. Zivkovic and B. Scatton, J.
Pharmacol. Exp. Ther. 253, 475 (1990)).
OH
HO \ / IV
\ / N

F
- OH
Cl \ / V
\ / N

Since ifenprodil and eliprodil interact with the polyamine binding site on the NMDA receptor, the antagonistic activity of the compounds according to the invention can be determined in a spermine-stimulated [3HJMK-801 (dizocilpine) binding test.

In the presence of saturation concentrations of glycine and NMDA, sper-mine is able further to increase the binding of MK-801, which is inhibited by ifenprodil, eliprodil and very particularly effectively by the compounds according to the invention.

In addition, the compounds according to the invention can be tested in a [3H]GABA (7-aminobutyric acid) liberation test, analogously to J. Dreijer, T. Honore and A. Schousboe, J. Neurosci. 7, 2910 (1987), which, as an in-vitro model, describes the antagonistic function in the cell.

The invention accordingly relates to the compounds of the formula I
according to Claim 1 and/or physiologically acceptable salts thereof as antagonists to receptors of excitatory amino acids, such as, for example, glutamic acid, and salts thereof.

The invention relates to the compounds of the formula I according to Claim 1 and physiologically acceptable salts and solvates thereof as glycine transporter inhibitor.

In particular, the invention relates to the compounds of the formula I
according to Claim 1 and/or acceptable salts thereof as excitatory amino acid antagonists for combating neurodegenerative diseases, including cerebrovascular diseases, epilepsy, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's disease, cerebral ischaemia, infarction or psychoses.

The invention also relates to the use of the' compounds of the formula I
according to Claim 1 and/or physiologically acceptable salts thereof for the preparation of a medicament for combating neurodegenerative diseases, including cerebrovascular diseases, epilepsy, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's disease, cerebral ischaemia, infarction or psychoses.

The compounds of the formula I can be employed as medicament active ingredient in human and veterinary medicine.

The invention furthermore relates to a process for the preparation of the compounds of the formula I according to Claim 1 and physiologically r acceptable salts thereof, characterised in that a) a compound of the formula II
E
D\ D:: X1 L1 II
N
(R12)P

in which L1 is Cl, Br, I, OH, a reactively esterified OH group or a diazonium group, and R1, D, E, R12, p and X1 are as defined above and below for the compounds of the formula I, b) is reacted with a compound of the formula III

L2---- NGI--, X2/Z
III
E

in which L2 is H or a metal ion, and E, G, X2 and Z are as defined above and below for the compounds of the formula 1, and optionally d) the resultant compound of the formula I is converted into one of its salts by treatment with an acid.

In a preferred embodiment, the compound of the formula III is selected from compounds of the formula q in which L2, q, Y, X2 and Z are as defined above and below.

The compound of the formula VI is particularly preferably selected from compounds of the formulae N-X2 Z L2 N\_/N-_X2 L2N 2 L N L2 N \---/ \

Z

and O O Xz NR' N/

N NR' z X 'z or the thioamides thereof, in which L2, X2 and Z are as defined above and below, and R' is H, A, (CH2)nHet, (CH2)nAr, cycloalkyl having from 3 to 7 carbon atoms or SO2A.

The process according to the invention can be carried out as a one-pot reaction, i.e. isolation and/or purification steps are omitted as far as possi-ble and only the desired end product, i.e. generally a compound according to the invention or a pharmaceutically usable derivative thereof, is purified and/or isolated. Alternatively, a purification and/or isolation step can be carried out after each of the said reaction steps. Mixed forms of the proce-dures described above are also conceivable. Suitable purification and isolation steps are known to the person skilled in the art, for example from Houben-Weyl, Methoden der organischen Chemie [Methods of Organic Chemistry], Georg-Thieme-Verlag, Stuttgart.

In particular, the invention relates to the compounds of the formula I in which at least one of the said radicals has one of the preferred meanings indicated above.

For the purposes of the present invention, alkyl is a linear or branched alkyl radical, preferably an unbranched alkyl radical, which has 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 carbon atoms, preferably 1, 2, 3, 4 or 5 carbon atoms, and may be mono- or polysubstituted by halogen (Hal), for example per-fluorinated. If an alkyl radical is substituted by halogen, it preferably, depending on the number of carbon atoms of the alkyl radical, has 1, 2, 3, 4 or 5 halogen atoms. Thus, for example, a methyl group (alkyl radical having 1 carbon atom) can be mono-, di- or trisubstituted by halogen, and an ethyl group (alkyl radical having 2 carbon atoms) can be mono-, di-, tri-, tetra- or pentasubstituted by halogen.
For alkyl groups having more than 2 carbon atoms, the same preferably applies as for ethyl groups. Alkyl is particularly preferably methyl, ethyl, trifluoromethyl, pentafluoroethyl or propyl, furthermore preferably isopropyl, butyl, isobutyl, sec-butyl or tert-butyl, but also n-pentyl, neopentyl, isopentyl or hexyl.

The term "alkenyl" preferably covers mono- or polyethylenically unsatur-ated, straight-chain or branched hydrocarbon radicals having from 2 to 10 and in particular from 3 to 6 carbon atoms, and in particular allyl, 2- or 3-butenyl, isobutenyl, sec-butenyl, furthermore preferably 4-pentenyl, isopentenyl or 5-hexenyl.

The term "alkoxy" is preferably a radical of the formula -0-alkyl, in which alkyl is as defined above, or, if two alkoxy radicals are bonded to adjacent (vicinal) carbon atoms, "alkoxy" is preferably -O-alkylene-O-, in which alkylene is as defined above. Preferred alkoxy radicals of the formula -0-alkyl are methoxy, ethoxy and propoxy. Preferred alkoxy radicals of the formula -O-alkylene-O- are -O-CH2-O-, -O-CH2CH2-O- and -O-CH2CH2CH2-O-.

The term "alkoxyalkyl" preferably covers straight-chain radicals of the for-mula CuH2u+1-O-(CH2)v, in which u and v are each, independently of one another, from 1 to 6. Particularly preferably, u = 1 and v = 1 to 4.

The term "aryl" preferably covers an unsubstituted or mono- or polysubsti-tuted benzene ring, for example an unsubstituted or substituted phenyl radical or an unsubstituted or mono- or polysubstituted system of benzene rings, such as, for example, anthracene, phenanthrene or naphthalene ring systems. Examples of suitable substituents include alkyl, alkoxy, oxo, hydroxyl, mercapto, amino, nitro, cyano and halogen radicals.

The term "aryl" preferably covers an unsubstituted or mono- or polysubsti-tuted aromatic ring system, for example an unsubstituted or substituted phenyl radical or an unsubstituted or mono- or polysubstituted system of benzene rings, such as, for example, anthracene, phenanthrene or naph-thalene ring systems. Examples of suitable substituents include alkyl, alkoxy, oxo, hydroxyl, mercapto, amino, nitro, cyano and halogen radicals.

The term "aralkyl" preferably covers an aryl radical as defined above bonded to an alkyl radical as defined above. Examples of suitable aralkyl radicals include, but are not restricted to, benzyl, phenylpropyl, phenylbutyl and the like.

Ar is preferably an aryl radical which is unsubstituted or mono- or polysub-stituted by A, Hal, NO2, CN, OR6, N(R6)2, COOR6, CON(R6)2, NR6COR6, NR6CON(R6)2, NR'SO2A, COR 6, SO2NR6, S(O),A and/or OOCR6, and in particular phenyl, naphthyl or biphenyl, each of which is unsubstituted or substituted as above.

Het is preferably a saturated, unsaturated or aromatic mono- or bicyclic heterocyclic radical which is unsubstituted or mono- or polysubstituted by A, Hal, NO2, CN, OR6, N(R6)2, COOR6, CON(R6)2, NR6COR6, NR6CON(R6)2, NR'SO2A, COR 6, SO2NR6, S(O),,A and/or OOCR6. Het is preferably a radical which is unsubstituted or substituted as described above, selected from 1-piperidyl, 1-piperazyl, 1-(4-methyl)piperazyl, 4-methylpiperazin-1-ylamine, 4-morpholinyl, 1-pyrrolidinyl, 1-pyrazolidinyl, 1-(2-methyl)pyrazolidinyl, 1-imidazolidinyl or 1-(3-methyl)imidazolidinyl, thiophen-2-yl or thiophen-3-yl, 2-, 3- or 4-pyridyl, 2-, 4- or 5-oxazolyl, 2-, or 5-thiazolyl, quinolinyl, isoquinolinyl, 2- or 4-pyridazyl, 2-, 4- or 5-pyrimidyl, 2- or 3-pyrazinyl. .

The radical Z is preferably a 5- or 6-membered, polyethylenically unsatu-rated or aromatic carbocyclic radical, which may be mono- or polysubsti-tuted, preferably mono- to trisubstituted, where the substituents are selected, independently of one another, from the meanings of R4 other than H, or are preferably selected from A, in particular alkyl having from 1 to 6 carbon atoms, alkoxy having from 1 to 6 carbon atoms and alkoxyalkyl having from 2 to 6 carbon atoms, Hal, in particular F and Cl, NO2, OR6, N(R6)2, CN, COOR6, CON(R6)2, NR6COR6, NR6CON(R6)2, NR6SO2A, COR6, SO2NR6, S(O)WA, OOCR6 and C(NH)NOH. Examples of carbocyclic radicals Q are cyclopentadienyl, cyclohexadienyl, phenyl, naphthyl, in par-ticular 1-naphthyl and 2-naphthyl, and biphenyl, each of which may be substituted as described above/below. The carbocyclic radical Z is pref-erably phenyl and particularly preferably substituted phenyl, in particular 4-alkyiphenyl, such as 4-tolyl (4-methylphenyl), 4-alkoxyphenyl, such as 4-methoxyphenyl, 3,4-dialkoxyphenyl, such as 3,4-dimethoxyphenyl and 3,4-methylenedioxyphenyl, and 4-halophenyl, such as 4-fluorophenyl and 4-chlorophenyl.

The radical Z is alternatively preferably a 5- or 6-membered, polyethyleni-cally unsaturated or aromatic heterocyclic radical, which may contain from 1 to 4 heteroatoms, selected, independently of one another, from N, 0 and S, and may be mono- or polysubstituted, preferably mono- to trisubstituted, where the substituents are selected, independently of one another, from the meanings of R4 other than H, or are preferably selected from A, in par-ticular alkyl having from 1 to 6 carbon atoms, alkoxy having from 1 to 6 carbon atoms and alkoxyalkyl having from 2 to 6 carbon atoms, Hal, in particular F and Cl, NO2, OR6, N(R6)2, CN, COOR6, CON(R6)2, NR6COR6, NR6CON(R6)2, NR6SO2A, COR6, SO2NR6, S(O)WA, OOCR6 and C(NH)NOH. Examples of heterocyclic radicals Q are furanyl, thiophenyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, thiazolyl, oxazolyl, isoxa-zolyl, oxadiazolyl, oxopyridyl, thiadiazolyl, isothiazolyl, pyridyl, pyridazyl, pyrazinyl, pyrimidyl, quinolinyl, isoquinolinyl, benzofuranyl, benzothio-phenyl, benzo[1,4]dioxoinyl, 2,3-dihydrobenzo[1,4]dioxinyl, benzothiadia-zolyl, chromenyl, 2-oxochromenyl, indolyl and indazolyl, each of which may be substituted as described above/below. The heterocyclic radical Z is particularly preferably optionally substituted furanyl, thiophenyl, pyrrolyl, pyridyl, pyridazyl, pyrazolyl, pyrazinyl, pyrimidyl, benzofuranyl, 2-oxo-chromenyl, indolyl, benzothiadiazolyl, quinolinyl, 2,3-dihydro-benzo[1,4]dioxinyl and benzo[d]isothiazolyl.

The present invention preferably relates to compounds of the formula I as described above in which R1, p, E, G and Z have the meanings given above and below and in which A is straight-chain alkyl having from 1 to 4 carbon atoms or branched alkyl having from 3 to 6 carbon atoms, and D-E is R2C=CR4 or R2R3C-CR4R5, in particular R2C=CR4, in which R2, R3 and R5 are selected, independently, from H, A
and cycloalkyl having from 3 to 7 carbon atoms, and R4 is Hal, CH2Hal, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)n000R6, (CH2)nCON(R6)2, (CH2)nNR6COR6, (CH2)nNR6CON(R6)2, (CH2)nNR6SO2A, (CH2)nSO2N(R6)2, (CH2)nS(O),A, (CH2)n000R6, (CH2)nCOR6, (CH2)nCO(CH2)mAr, (CH2)nCO(CH2)mHet, (CH2)n000(CH2)mAr, (CH2)nCOO(CH2)mHet, (CH2)nOR6, (CH2)nO(CH2)mAr, (CH2)nO(CH2)mHet, (CH2)nSR6, (CH2)nS(CH2)mAr, (CH2)nS(CH2)mHet, (CH2)nN(R6)(CH2)mAr, (CH2)nN(R6)(CH2)mHet, (CH2)nSO2N(R6)(CH2)mAr, (CH2)nN(R6)S02(CH2)mAr, (CH2)nSO2N(R6)(CH2)mHet, (CH2)nN(R6)SO2(CH2)mHet, (CH2)nCON(R6)(CH2)mAr, (CH2)nN(R6)CO(CH2)mAr, (CH2)nCON(R6)(CH2)mHet, (CH2)nN(R6)CO(CH2)mHet, (CH2)nN(R6)2, (CH2)n000R6, (CH2)nOC(O)N(R6)2, (CH2)nOC(O)NR6(CH2)mAr, (CH2)nOC(O)NR6(CH2)mHet, (CH2)nNR6000R6, (CH2)nNR6000(CH2)mAr, (CH2)nNR 6COO(CH2)mHet, (CH2)nN(R6)CH2CH2OR6, (CH2)nN(R6)CH2CH2OCF3, (CH2)nN(R6)C(R6)H000R6, (CH2)nN(R6)CH2COHet, (CH2)nN(R)CH2Het, (CH2)nN(R)CH2CH2N(R6)CH2OOOR6, (CH2)nN(R6)CH2CH2N(R6)2, CH=CHCOOR6, (CH2)nN(000R6)COOR6, (CH2)nN(CONH2)000R6, (CH2)nN(CONH2)CONH2, (CH2)nN(CH2OOOR6)COOR6, (CH2)nN(CH2CONH2)000R6, (CH2)nN(CH2CONH2)CONH2, (CH2)nCHR6COR6, (CH2)nCHR6000R6 or (CH2)nCHR6CH2OR6 and in particular Hal, CH2HaI, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)n000R6, (CH2)nCON(R6)2, (CH2)nSO2N(R6)2 or (CH2)nS(O)WA, m is 0, 1, 2, 3,4or5and n is 0, 1, 2 or 3 and in particular 0 or 1;

X1 is (CHR7)g or Q-(CHR8)k, in which Q is selected from 0, S, N-R6, (O-CHR')g, (CHR'-O)g, CR9=CR10, (O-CHR9CHR10)g, (CHR9CHR'0-0)g, C=O, C=S, C=NR6, C(OR6)(OR6), C(=O)O, OC(=O), OC(=O)O, C(=O)N(R6), N(R6)C(=O), OC(=O)N(R6), N(R6)C(=O)O, CH=N-O, CH=N-NR6, OC(O)NR6, NR6C(0)O, S=O, SO2, SO2NR6 and NR6SO2, g is 1, 2, 3, 4, 5 or 6 and in particular 2, 3 or 4, k is 0, 1, 2, 3, 4, 5 or 6 and in particular 1, 2 or 3, and R', R8, R9 and R10 are selected, independently, from the meanings indicated for R2 to R5;

X2 is a bond or independently is (CHR7)g or Q-(CHR8)k, in which Q is selected from 0, S, N-R6, (O-CHR')9, (CHR'-O)g, (O-CHR9CHR10)g, (CHR9CHR10-O),, C=O, CH(ORE), C(=O)O, OC(=O), C(=O)N(R6), N(R6)C(=O),S=O, SO2, SO2NR6 and NR6SO2, where g in X2 is preferably 1 or 2 and k in X2 is pref-erably 0 or 1, and R12 is selected, independently, from the meanings of R4 other than H and in particular, independently, is F, Cl, Br, I, CN, NO2, NH2, CF3, OCF3, C(NH)NOH or SO2CH3, and solvates and salts thereof.

The invention preferably relates to substituted indoles of the formula la /E (R13)r X1 \
D\ D::
N N Z la 12)p l-/ Y- X2 "- R1 in which R1, D-E and Z are as defined above, and in which X1 is (CHR7)g or (CHR')h-Q-(CHR8)k, in which Q is selected from 0, S, N-R6, (O-CHR7)g, (CHR'-O)g, CR9=CR10, (O-CHR9CHR10)9, (CHR9CHR10-O)g, C=O, C=S, C=NR6, CH(OR6), C(OR6)(OR6), C(=O)O, OC(=O), OC(=O)O, C(=O)N(R6), N(R6)C(=O), OC(=O)N(R6), N(R6)C(=O)O, CH=N-0, CH=N-NR6, OC(O)NR6, NR6C(O)O, S=O, SO2, SO2NR6 and NR6SO2, g is 1, 2, 3, 4, 5 or 6, h and k, independently of one another, are 0, 1, 2, 3, 4, 5 or 6, and R6 is selected, independently, from H, A or cycloalkyl having from 3 to 7 carbon atoms, R7, R8, R9 and R'0 are selected, independently, from the meanings indicated for R2 to R5;

Y is CH, N, COR", CSR'1, an unsubstituted or substituted, spiro-linked carbocyclic radical having from 5 to 7 carbon atoms or an unsubstituted or substituted, spiro-linked, 5-, 6-or 7-membered heterocyclic radical having from 1 to 3 hetero-atoms selected from N, S or 0, R" is H, A, (CH2)nHet, (CH2)nAr or cycloalkyl having from 3 to 7 carbon atoms, X2 is a bond or is selected, independently, from the meanings indicated for X1, and is preferably a bond or 0, S, N-R7, CH2 or CH2CH2, p, q and r, independently of one another, are 0, 1, 2 or 3 and Hal is F, Cl, Br or I, and R12 and R13, independently of one another, are selected from the meanings of R4 other than H and are preferably, independ-ently of one another, Hal, CN, NO2, OR6, N(R6)2, NO2, CN, COOR6, CON(R6)2, NR6COR6, NR6CON(R6)2, NR6SO2A, COR6, SO2NR6, S(O),NA, OOCR6 and/orC(NH)NOH, and salts and solvates thereof, preferably physiologically tolerated salts and solvates thereof and in particular physiologically tolerated salts thereof.

The sum of n and m is preferably greater than zero.

In the compounds of the formula I, the E-N-G-X2-Z group is preferably selected from groups of the formulae H OH
N X2 N X2 ~~ -XZ/Z NN-X2iZ
~CH3 Z Z

and O ~ X2 NR' N ,,,Z
N N" N NR' X2____ Z
or the thioamides thereof, in which X2 and Z are as defined above and below, and R' is H, A, (CH2),Het, (CH2),Ar, cycloalkyl having from 3 to 7 carbon atoms or SO2A.
In the compounds of the formula I, of the formula la and the compounds of the formula III, the X2-Z group is preferably selected from the groups (R14)t (R14)t (R 14)t R1a X2 ( )t X2 X2 X2 +N
N N
R' / R' (R14)t (R14)t (R14)t X2 \ / O X2 -d l NR' X2 -C O
(R14)t NN N/
NR' ~ ~

X2 X2 X2 I(R14)t (R1a)t (R 14)t (R14)t X2 NR' X2 \I"S X2 1a (R )t R' in which R14 is selected, independently, from Hal, A, (CH2)nHet, (CH2)nAr, (CH2)nCOO(CH2)mAr, (CH2)nCOO(CH2)mHet, (CH2)nOR6, (CH2)nO(CH2)mAr, (CH2)nO(CH2)mHet, (CH2)nN(R6)(CH2)mAr, (CH2)nN(R6)(CH2)mHet, (CH2)nSO2N(R6)(CH2)mAr, (CH2)nN(R6)SO2(CH2)mAr, (CH2)nSO2N(R6)(CH2)mHet, (CH2)nN(R6)SO2(CH2)mHet, (CH2)nN(R6)2, (CH2)nNHOA, (CH2)n(R6)Het, (CH2)n000R6, (CH2)nOC(O)N(R6)2, (CH2)nOC(O)NR6(CH2)mAr, (CH2)nOC(O)NR6(CH2)mHet, (CH2)õNR6000R6, (CH2)nNR6000(CH2)mAr, (CH2)nNR 6COO(CH2)mHet, and in particular, independently of one another, is Hal, NO2, OR6, N(R6)2, ON, COOR6, CON(R6)2, NR6COR6, NR6CON(R6)2, NR6S02A, COR 6, S02NR6, S(O),NA, 000R6 and/orC(NH)NOH, w is 0, 1,2or3, t is 0, 1, 2, 3, 4 or 5 and in particular 0, 1, 2 or 3, and R' is H, A, (CH2),Het, (CH2)nAr, cycloalkyl having from 3 to 7 carbon atoms or S02A.

If the X2-Z group is the 14)t group, it is preferably selected from the groups X2 CH3 X2 F X2 O-<:>

F
O
X2- N X2 F X2 NR' N
OMe MeO OMe in which X2 and Rare as defined above/below.

In a preferred embodiment of the present invention, n is 0 or 1 and in par-ticular 0.

In a particularly preferred embodiment of the present invention, n in the radicals R2, R3, R4 and/or R5, preferably in the radicals R2 and/or R4 and in particular in the radical R4 is 0.

Some preferred groups of compounds can be expressed by the following sub-formulae la) to In), which conform to the formula I and/or to the for-mula la and in which the radicals not designated in greater detail have the meaning indicated above/below, but in which in la) R' is H or SO2A and in particular H or S02-CH3;
in lb) R1 is H or SO2A and in particular H or S02-CH3;
D-E is R2C=CR4;

in Ic) R1 is H or SO2A and in particular H or S02-CH3;
D-E is R2C=CR4, R2 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2Hal, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)n000R6, (CH2)nCON(R6)2 (CH2)nSO2N(R6)2 or (CH2)nS(O)wR6;

in Id) R' is H or S02A and in particular H or S02-CH3;
D-E is R2C=CR4, R2 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2HaI, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)n000R6, (CH2)nCON(R6)2 (CH2)nSO2N(R6)2 or (CH2)nS(O)wR6;
R4 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2HaI, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)n000R6, (CH2)nCON(R6)2 (CH2)nSO2N(R6)2 or (CH2)nS(O)wR6;

in le) R1 is H or S02A and in particular H or S02-CH3;
D-E is R2C=CR4, R2 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2HaI, CH(Hal)2, C(Hal)3, N02, (CH2)nCN, (CH2)n000R6, (CH2)nCON(R6)2 (CH2)nSO2N(R6)2 or (CH2)nS(O)wR6;
R4 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2HaI, CH(Hal)2, C(Hal)3, N02, (CH2)nCN, (CH2)n000R6, (CH2)nCON(R6)2 (CH2)nSO2N(R6)2 or (CH2)nS(O)wR6 and R6 is H or A;

in If) R' is H or S02A and in particular H or S02-CH3;
D-E is R2C=CR4, R2 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2HaI, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)n000R6, (CH2)nCON(R6)2 (CH2)nSO2N(R6)2 or (CH2)nS(O)wR6;
R4 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2HaI, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)n000R6, (CH2)nCON(R6)2 (CH2)nSO2N(R6)2 or (CH2)nS(O)wR6 and R6 is H or A, and n is0or1;
in Ig) R1 is H or SO2A and in particular H or S02-CH3;
D-E is R2C=CR4, R2 is H, alkyl having from I to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2HaI, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)n000R6, (CH2)nCON(R6)2 (CH2)nSO2N(R6)2 or (CH2)nS(O),R6;
R4 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2HaI, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)n000R6, (CH2)nCON(R6)2 (CH2)nSO2N(R6)2 or (CH2)nS(O)wR6 and R6 is H or A, n is0or1, X' is (CHR7)g, in which g is 2, 3 or 4, or is Q-(CHR8)k, in which k is 1, 2 or 3;

in lh) R' is H or SO2A and in particular H or S02-CH3;
D-E is R2C=CR4, R2 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to '5 carbon atoms, Hal, CH2HaI, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)n000R6, (CH2)nCON(R6)2 (CH2)nSO2N(R6)2 or (CH2)nS(O)wR6;
R4 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2HaI, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)n000R6, (CH2)nCON(R6)2 (CH2)nSO2N(R6)2 or (CH2)nS(O),R6 and R6 is H or A, n is0or1, xi is (CHR7)g, in which g is 2, 3 or 4, or is Q-(CHR8)k, in which k is 1, 2 or 3 and Q is selected from 0, S, N-R6, CONR6, C=O, C=S, S=O, SO2, SO2NR6 and NR6SO2;

in Ii) R1 is H or SO2A and in particular H or S02-CH3;
D-E is R2C=CR4, R2 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2HaI, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)r,000R6, (CH2)nCON(R6)2 (CH2)nSO2N(R6)2 or (CH2)nS(O),NR6;
R4 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2HaI, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)n000R6, (CH2)nCON(R6)2 (CH2)nSO2N(R6)2 or (CH2)nS(O)H,R6 and R6 is H or A, n is 0 or 1, X' is (CHR7)g, in which g is 2, 3 or 4, or is Q-(CHR8)k, in which k is 1, 2 or 3 and Q is selected from 0, S, N-R6, CONR6, C=O, C=S, S=O, SO2, SO2NR6 and NR6SO2, and R7 and R8 are selected, independently of one another, from H
and A;
in lj) R' is H or S02A and in particular H or S02-CH3;
D-E is R2C=CR4, R2 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2Hal, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)n000R6, (CH2)õ CON(R6)2 (CH2)õ SO2N(R6)2 or (CH2)nS(O),NR6;
R4 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2Hal, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)n000R6, (CH2)nCON(R6)2 (CH2)õ SO2N(R6)2 or (CH2)nS(O),,R6 and R6 is H or A, n is0orl, x 1 is (CHR 7)g, in which g is 2, 3 or 4, or is Q-(CHR8)k, in which k is 1, 2 or 3 and Q is selected from 0, S, N-R6, CONR6, C=O, C=S, S=O, SO2, S02NR6 and NR6SO2, R7 and R8 are selected, independently of one another, from H
and A, and Y is CH, COR", N or an unsubstituted or substituted, spiro-linked, 5-, 6- or 7-membered heterocyclic radi-cal having from 1 to 3 heteroatoms selected from N, S or 0, in Ik) R' is H or S02A and in particular H or SO2-CH3;
D-E is R2C=CR4, R2 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2Hal, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)n000R6, (CH2)nCON(R6)2 (CH2)õ SO2N(R6)2 or (CH2)nS(O),NR6;
R4 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2Hal, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)n000R6, (CH2)nCON(R6)2 (CH2)nSO2N(R6)2 or (CH2)nS(O),R6 and R6 is H or A, n is0or1, X1 is (CHR7)g, in which g is 2, 3 or 4, or is Q-(CHR8)k, in which k is 1, or 3 and Q is selected from 0, S, N-R6, CONR6, C=O, C=S, S=O, SO2, S02NR6 and NR6SO2, R7 and R8 are selected, independently of one another, from H
and A, Y is CH, COR", N or an unsubstituted or substituted, spiro-linked, 5-, 6- or 7-membered heterocyclic radi-cal having from 1 to 3 heteroatoms selected from N, S or O; and R" isHorA;

in II) R' is H or S02A and in particular H or S02-CH3;
D-E is R2C=CR4, R2 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2HaI, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)n000R6, (CH2)nCON(R6)2 (CH2)nSO2N(R6)2 or (CH2)nS(O)wR6;
R4 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2HaI, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)n000R6, (CH2)nCON(R6)2 (CH2)nSO2N(R6)2 or (CH2)nS(O)wR6 and R6 is H or A, n is0or1, X' is (CHR7)g, in which g is 2, 3 or 4, or is Q-(CHR8)k, in which k is 1, 2 or 3 and Q is selected from 0, S, N-R6, CONR6, C=O, C=S, S=O, SO2, S02NR6 and NR6SO2, R7 and R8 are selected, independently of one another, from H
and A, Y is CH, COR", N or an unsubstituted or substituted, spiro-linked, 5-, 6- or 7-membered heterocyclic radi-cal having from 1 to 3 heteroatoms selected from N, S or 0, R" is H or A, and X2 is CH2, CH2CH2, HCOH, 0, S, N-R6, CONR6, C=O or a bond;

in Im) R1 is H or S02A and in particular H or S02-CH3;
D-E is R2C=CR4, R2 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2HaI, CH(Hal)2, C(Hal)3, NO2, (CH2)õ CN, (CH2)õ000R6, (CH2)nCON(R6)2 (CH2)õ SO2N(R6)2 or (CH2)õS(O),NR6;
R4 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2HaI, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)õ000R6, (CH2)õ CON(R6)2 (CH2)õ SO2N(R6)2 or (CH2)õ S(O),NR6 and R6 is H or A, n is0or1, X1 is (CHR7)g, in which g is 2, 3 or 4, or is Q-(CHR8)k, in which k is 1, 2 or 3 and Q is selected from 0, S, N-R6, CONR6, C=O, C=S, S=O, SO2, S02NR6 and NR6SO2, R7 and R8 are selected, independently of one another, from H
and A, Y is CH, COR", N or an unsubstituted or substituted, spiro-linked, 5-, 6- or 7-membered heterocyclic radi-cal having from 1 to 3 heteroatoms selected from N, S or 0, R11 is H or A, and X2 is CH2, CH2CH2, HCOH, 0, S, N-R6, CONR6, C=O or a bond, and R12 is selected, independently, from A, Hal, CN, NO2, OR6, N(R6)2, COOR6, CON(R6)2, CORE, SO2N(R6)2 and S(O),NA;

in In) R1 is H or SO2A and in particular H or S02-CH3;
D-E is R2C=CR4, R2 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2HaI, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)n000R6, (CH2)nCON(R6)2 (CH2)nSO2N(R6)2 or (CH2)nS(O),,R6;
R4 is H, alkyl having from 1 to 3 carbon atoms, alkoxy-alkyl having from 2 to 5 carbon atoms, Hal, CH2HaI, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)n000R6, (CH2)nCON(R6)2 (CH2)nSO2N(R6)2 or (CH2)nS(O),NR6 and R6 is H or A, n is0or1, X1 is (CHR7)g, in which g is 2, 3 or 4, or is Q-(CHR8)k, in which k is 1, 2 or 3 and Q is selected from 0, S, N-R6, CONR6, C=O, C=S, S=O, SO2, SO2NR6 and NR6SO2, R7 and R8 are selected, independently of one another, from H
and A, Y is CH, COR11, N or an unsubstituted or substituted, spiro-linked, 5-, 6- or 7-membered heterocyclic radi-cal having from 1 to 3 heteroatoms selected from N, S or 0, R" is H or A, and X2 is CH2, CH2CH2, HCOH, 0, S, N-R6, CONR6, C=0 or a bond, R12 is selected, independently, from A, Hal, CN, NO2, OR6, N(R6)2, COOR6, CON(R6)2, COR6, SO2N(R6)2 and S(O)wA, and R14 is selected, independently, from A, Hal, CN, NO2, OR6, N(R6)2, COOR6, CON(R6)2, COR6, SO2N(R6)2 and S(O)WA.

In a preferred embodiment of the present invention, the radical R2 in the sub-formulae la) to In) is H, A, in particular alkyl having from 1 to 4 carbon atoms or O-alkyl having from 1 to 4 carbon atoms, Hal, in particular F or Br, CN, NO2 NH2, CF3, OCF3 SO2CH3, COOR6 or CON(R6)2, particularly preferably H, alkyl having from 1 to 4 carbon atoms or CN; and R4 is H, A, in particular alkyl having from 1 to 4 carbon atoms or O-alkyl having from 1 to 4 carbon atoms, Hal, in particular F or Br, CN, NO2 NH2, CF3, OCF3 SO2CH3, COOR6 or CON(R6)2, particularly preferably CN. In this preferred embodiment, R2 is H or A in particular if R4 is Hal, NO2 NH2, CF3, OCF3 SO2CH3, COOR6 or CON(R6)2 and in particular is CN. In this preferred embodiment, the compound of the formula I and/or of the formula la pref-erably has one or two substituents R12 and particularly preferably no sub-stituents R12. In this preferred embodiment, the compound of the formula I
and/or of the formula la particularly preferably has one or two substituents R13 and very particularly preferably no substituents R13. In this preferred embodiment, the compound of the formula I and/or of the formula la pref-erably has no, one or two substituents R14 and in particular one or two substituents R14. If the compound of the formula I and/or of the formula la has one or two substituents R, these are preferably selected from F, Cl, Br, I, CN, CF3 and OCF3 and in particular are selected from F, CF3 and OCF3.

In a specific and preferred embodiment, the present invention relates to a compound of the formula I and/or of the formula la and in particular a compound of the sub-formulae la) to In) in which D-E is R2C=CR4, R2 is H
or methyl and R4 is CN, and solvates and salts thereof.

In a further specific and preferred embodiment, the present invention relates to a compound of the formula I and/or of the formula la and in par-ticular a compound of the sub-formulae la) to In) in which X' is CH2CH2 (i.e. is (CHR')g in which R7 is H and g is 2), CH2CH2CH2 (i.e. is (CHR7)g in which R7 is H and g is 3) or OCH2CH2 (i.e. is (CHR'),,-Q-(CHR8)k in which h is 0, R8 is H and k is 2), and solvates and salts thereof.

In a further specific and preferred embodiment, the present invention relates to a compound of the formula I and/or of the formula la and in par-ticular a compound of the sub-formulae la) to In) in which Y is CH, CHOH
(i.e. is COR" in which R" is H) or N and in particular is CH, and solvates and salts thereof.

In a further specific and preferred embodiment, the present invention relates to a compound of the formula I and/or of the formula la and in par-ticular a compound of the sub-formulae la) to In) in which Y is an unsub-stituted or substituted, Spiro-linked, 5-, 6- or 7-membered heterocyclic radical having from 1 to 3 heteroatoms selected from N, S or 0, and par-ticularly preferably an unsubstituted or substituted, spiro-linked, 5-mem-bered heterocyclic radical having 2 heteroatoms, preferably 2 N atoms. in this embodiment, the spiro-linked heterocyclic radical preferably has, as one substituent, a double-bonded oxygen radical (=O), i.e. an oxo sub-stituent, or a double-bonded sulfur radical (=S), he. a thioxo substituent.
The Spiro-linked heterocyclic radical particularly preferably has, as one substituent, an oxo substituent. The spiro-linked heterocyclic radical is very particularly preferably selected from structures of the formulae O
NR' Y, O /X2 N
~_N
X2 Y' Z and NR' in which X2, Z and R' are as defined above/below, and Y' is the spiro-link-ing carbon atom of the spiro-linked heterocyclic radical. In this embodi-ment, X2 is particularly preferably a bond. In particular, the spiro-linked heterocyclic radical is therefore selected from structures of the formulae O

NR' O
Z
Y' \_N
Y'\
NR' Z and in which X2, Z and R' are as defined above/below, and Y' is the spiro-link-ing carbon atom of the spiro-linked heterocyclic radical.

In a further specific and preferred embodiment, the present invention relates to a compound of the formula I and/or of the formula la and in par-ticular a compound of the sub-formulae la) to In) in which X2 is CH2 (i.e. is (CHR7)g in which R7 is H and g is 1), CH2CH2 (i.e. is (CHR7)g in which R7 is H and g is 2), OCH2 (i.e. is (CHR7)h-Q-(CHR8)k in which Q is 0, h is 0, R8 is H and k is 1), 0 (i.e. is (CHR7)h-Q-(CHR8)k in which Q is 0 and h and k are 0), S (i.e. is (CHR7)h-Q-(CHR8)k in which Q is S and h and k are 0), C=O
(i.e. is (CHR7)h-Q-(CHR8)k in which Q is C=O and h and k are 0), or NH
(i.e. is (CHR7)h-Q-(CHR8)k in which Q is N-R6, R6 is H and h and k are 0), particularly preferably is CH2, O, NH and CHOH and in particular is CH2 or 0, and solvates and salts thereof.

In a further specific and preferred embodiment, the present invention relates to a compound of the formula I and/or of the formula la and in par-ticular a compound of the sub-formulae la) to In) in which X2 is a chemical bond between the groups Y and Z. In this embodiment, the Y-X2-Z group is thus the Y-Z group.

In a further specific and preferred embodiment, the E-N-G-X2-Z group in the compounds of the formula I is a radical of the formula \---/ NH2 In a further specific and preferred embodiment, the E-N-G-X2-Z group in the compounds of the formula I is a radical of the formula HN _N NH N

or a radical of the formula o ~
HN I /
O

In a further specific and preferred embodiment, the E-N-G-X2-Z group in the compounds of the formula I is a radical of the formula N N -P
In a particularly preferred embodiment, the present invention relates to a compound of the formula I and/or of the formula la and in particular a com-pound of the sub-formulae la) to In) which comprises the features of one or more of the embodiments described above and in particular the features of all embodiments described above or the features of all embodiments described above which are not mutually exclusive.

In the compounds of the formula I and/or of the formula la, X1 is, relative to the indole nitrogen, preferably in the 4-, 5- or 6-position, particularly pref-erably the 4-position or 6-position and in particular in the 4-position of the indole radical (in accordance with IUPAC nomenclature for indole sys-tems).

In the compounds of the formula I and/or of the formula la, the substituents R14 are preferably in the ortho- and/or para-position, relative to Z.

The present invention therefore particularly preferably relates to com-pounds of the formulae la, I(i and Ix N N Y~X2 Q' (R14)t N \ la N~

Q\/~N Y~X2 R2 (R14)t N
/
R1 1(3 N

N \N --/ (R14)t in which R1, R2, Q, Y, X2, R14 and t are as defined above and in particular in the above sub-formulae la) to In) and/or the above embodiments, and compounds of the formulae Id, Ic and I~

N\\
~Y-X2 R2 N- J .
N ~-' 16 N
Y- Z

N \ IE
O H
N N
\N\ >
N

R N \Z
N \ I~
R' in which R', R2, Y, X2 and Z are as defined above and in particular in the above sub-formulae la) to In) and/or the above embodiments.

In the compounds of the formulae la, I3 and Ix, (R14)t is particularly pref-erably a fluorine substituent in the para-position, two fluorine substituents, one of which is in the para-position and one is in the meta-position, relative to Z, or CONH2 in the para-position. Furthermore, in the formulae la, I(3 and Ix, R' and/or R2 are preferably H, Q is CH2 and Y is CH and X2 is 0 or CH2.

In the compounds of the formulae 16 and le, the group Y is particularly preferably N or CH. In the compounds of the formula l~, the group Z is particularly preferably substituted and in particular unsubstituted phenyl.
In the compounds of the formula 16, the group Y-X2-Z is preferably a radi-cal of the formula N Y CH
HC O
or a radical of the formula HCN
In the compounds of the formula IE, the group Y-Z is particularly preferably a radical of the formulae - - -N =N N =N N N

NH2 ')~, N CH-~=/ O N O
NH N\ S .1N 8-O N N N

F
N

CH
N r H H H
CH O

o N
H NHS

H
or a radical of the formulae H

0"

N NH
O O
O O

N--C\

j N

N O S
N-<\
N O N
N O
N

S
N--~

0~CH3 In a very particularly preferred embodiment of the present invention, the compounds of the formula I and/or of the formula la are selected from a) N I ( ~, N \
N I F

6-{3-[4-(4-Fluorobenzyl)-1-piperidyl]propyl}-1 H-indole-3-carbonitrile;
b) F
N/ N
N F
6-{3-[4-(2,4-Difluorobenzyl)-1-piperidyl]propyl}-1 H-indole-3-carbo-nitrile;

c) N~ I I O IaF
N

N N 6-{3-[4-(4-Fluorophenoxy)-1-piperidyl]propyl}-1 H-indole-3-carbonitrile;

d) 0*"'~o F
N/ I I f N

4-{3-[4-(4-Fluorobenzyl)-1-piperidyl]propyl}-1 H-indole-3-carbonitrile;
e) F

N
F
N
N
4-{3-[4-(2,4-Difluorobenzyl)-1-piperidyl]propyl}-1 H-indole-3-carbo-nitrile;
f) 0 i I
N ~
F

N/
N

4-{3-[4-(4-Fluorophenoxy)-1-piperidyl]propyl}-1 H-indole-3-carbonitrile;
g) N I / N \
F
5-{3-[4-(2,4-Difluorobe nzyl)-1-piperidyl]propyl}-1 H-indole-3-carbo-nitrile;

h) N I N
N
5-{3-[4-(4-Fluorobenzyl)-1-piperidyl]propyl}-1 H-indole-3-carbonitrile;
i) i i N I N

N O \
5-{3-[4-(4-Fluorophenoxy)-1-piperidyl]propyl}-1 H-indole-3-carbonitrile;
J) QN -N
H

5-{3-[4-(4-Cyanophenyl)piperazin-1-yl]propyl}-1 H-indole-3-carbonitrile k) N\ 0 0 \ rN NHZ
/ NJ
N
H
5-{4-[3-(3-Cyano-1 H-indol-6-yi)propyl]piperazin-1-yl}benzofuran-2-carboxamide I) ~~N - o N
H
5-{3-[4-(2-Oxo-2H-chromen-6-yl)piperazin-1-yl]propyl}-1 H-indole-3-carbonitrile m) N

N
\
/ I ~ N O
5-{4-[3-(3-Cyano-1 H-indol-4-yl)propyl]piperazin-1-yl}benzofuran-2-carboxamide n) \X

N
N N o H c-~-4 -0 NHz 5-{4-[3-(3-Cyano-1.H-indol-5-yl)propyl]piperazin-1-yl}benzofuran-2-carboxamide o) N NH

N
H3C. S

5-{3-[4-(1 H-Indol-4-yl)piperazin-I -yl]propyl}-1-methanesulfonyl-1 H-indole-3-carbonitrile p) N o N
N
N
5-[3-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)propyl]-1 H-indole-3-carbonitrile q) NN

H N/ N
s 5-[3-(4-Benzo[1,2,5]thiad iazol-4-ylpiperazin-1-yl)propyl]-1 H-indole-3-carbonitrile r) \\ 1 ~
N NH
N
H
3-{1-[3-(3-Cyano-1 H-indol-5-yl)propyl]piperidin-4-yl}-1 H-indole-5-carboxamide s) N N
H N\
5-[3-(4-Quinolin-8-ylpiperazin-1-yl)propyl]-1 H-indole-3-carbonitrile t) \-/ N-~4\

5-{3-[4-(2,3-Dihydrobenzo[1,4]dioxin-5-yl)piperazin-1-yl)propyl}-1 H-indole-3-carbonitrile u) O H
N
N
N
N

H3C S\\ O 0 1-Methanesulfonyl-5-[3-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)propyl]-1 H-indole-3-carbonitrile v) ;\ NH
~ N\ /N

N
H

5-{3-[4-(1 H-Indol-4-yl)piperazin-1-yl]propyl}-1 H-indole-3-carbonitrile w) N

N
H / I \
N
H

5-{3-[4-(1 H-Indol-3-yl)piperidin-1-yl]propyl}-1 H-indole-3-carbonitrile x) N

/ I \ N

H F
/ I \
N
H
5-{3-[4-(5-Fluoro-1 H-indol-3-yl)piperidin-1-yl]propyl}-1 H-indole-3-carbonitrile Y) N\
/ I \ N

N N
H / I \

N
H
3-{1-[3-(3-Cyano-1 H-indol-5-yl)propyl]piperidin-4-yl}-1 H-indole-5-carbonitrile z) N\

N
H

N F
H

5-{3-[4-(6-Fluoro-1 H-indol-3-yl)piperidin-1-yl]propyl}-1 H-indole-3-carbonitrile aa) N\

N
F

N
H
5-{3-[4-(4-Fluoro-1 H-indoi-3-yl)piperidin-1-yl]propyl}-1 H-indole-3-carbonitrile bb) N\
N ON
H
N
5-[3-(4-Benzo[d]isothiazol-3-ylpiperazin-1-yl)propyl]-1 H-indole-3-carbonitrile cc) N~ 1N I \ O
N /

4-{1-[3-(3-Cyano-1 H-indol-6-yl)propyl]piperidin-4-yloxy}benzamide dd) Nj ~N O
N I / N v CH3 H N

6-{3-[4-(2-Cyano-3-methoxyphenyl)piperazin-1-yl]propyl}-1 H-indole-3-carbonitrile ee) N
N/ NJ::) OI
N / N J cH3 H
6-{3-[4-(4-Cyano-3-methoxyphenyl)piperazin-1-yl]propyl}-1 H-indole-3-carbonitrile ff) N
N / ~ ~JN J:;), N Nv Hc'O
3c H
6-{3-[4-(4-Cyano-2-methoxyphenyl)piperazin-1-yl]propyl}-1 H-indole-3-carbonitrile 99) N N
N~

N
H
4-[3-(4-Pyrazol-1-ylmethyl-1-piperidyl)propyl]-1 H-indole-3-carbonitrile hh) O O
N
H NN
~

H

N-(6-{4-[3-(3-Cyano-1 H-indol-5-yl)propyl]piperazin-1-yl}-2-oxo-2H-chromen-3-yl)acetamide ii) N
i H
N
H
5-{3-[(Pyridin-3-ylmethyl)amino]propyl}-1 H-indole-3-carbonitrile 11) N
HN
N O
N
5-{3-[4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)piperazin-1-yl]propyl}-1 H-indole-3-carbonitrile kk) /N
HN
I
ll*'~ N N
N
5-[3-(4-Pyrimidin-2-ylpiperazin-1-yl)propyl]-1 H-indole-3-carbonitrile II) i O N
H
o f ~
N
H
5-{3-[(2,3-Dihydrobenzo[1,4]dioxin-2-ylmethyl)amino]propyl}-1 H-indole-3-carbonitrile mm) N
HN N \ I O~CH3 N

5-{3-[4-(3-Methoxyphenyl)-3-methyl piperazin-1-yl]propyl}-1 H-indole-3-carbonitrile nn) N
N

H3 C~N\,N H

5-{3-[4-(1-Methyl-1 H-imidazo[4,5-c]pyridin-4-yl)piperazin-1-yl]propyl}-1 H-indole-3-carbonitrile 00) N
N

II / H

H

N-(4-{1-[3-(3-Cyano-1 H-indol-5-yl)propyl]piperidin-4-ylmethyl}-phenyl)acetamide pp) \

s NN
N N N
H I
5-{3-[4-(4-Pyridin-3-ylthiazol-2-yl)piperazin-1-yl]propyl}-1 H-indole-3-carbonitrile qq) N\

N N
N N O
"
r0 Ethyl 2-{4-[3-(3-cyano-1 H-indol-5-yl)propyl]piperazin-1-yl}-thiazole-4-carboxylate rr) N
O

V- '/ N
H
N
H
5-{3-[3-(2-Oxopyrrolidin-1-yl)propylamino]propyl}-1 H-indole-3-carbo-nitrile ss) o N
HCO"4,, N \ N 3 H
N

N
H
Ethyl (6-{4-[3-(3-Cyano-1 H-indol-5-yl)propyl]piperazin-1-yl}-2-oxo-2H-chro men-3-yl)carbamate tt) N

vN \
N
H
5-{3-[4-(3-Amino-2-oxo-2H-chromen-6-yl)piperazin-1-yl]propyl}-1 H-indole-3-carbonitrile uu) N
H3c,0 ~N N
H
ON \

N
H
Methyl (6-{4-[3-(3-Cyano-1 H-indol-5-yl)propyl]piperazin-1-yl}-2-oxo-2H-ch romen-3-yl )carbamate vv) N

S
N N
N O
~N
H

2-{4-[3-(3-Cyano-1 H-indol-5-yl)propyl]piperazin-1-yl}-thiazole-4-carboxamide ww) N\

S

H

4-[3-(3-Cyano-1 H-indol-5-yl)propyl]piperazin-1 -thiocarboxamide and salts and solvates thereof, preferably physiologically tolerated salts and solvates thereof and in particular physiologically tolerated salts thereof.

Depending on the choice of the substituents and radicals described above, the compounds according to the invention can have one or more chiral centres, in particular one or more chiral carbon atoms. If a compound of defined composition according to the invention has one or more chiral centres, this compound of defined composition can exist in the form of various stereoisomers. The present invention relates to all possible such stereoisomers of compounds according to the invention, which can exist either as individual, stereochemically uniform compounds or as mixtures of two or more stereochemically uniform compounds. In the case of mixtures of two or more stereoisomers, the individual stereoisomers may be present in different or identical proportions. In mixtures of two stereoisomers which are present in identical proportions and represent optical antipodes, the term racemic mixtures is used. Racemic mixtures of compounds of the formula I are likewise a subject-matter of the present invention.

The compounds of the formula I and also the starting materials for the preparation thereof are, in addition, prepared by methods known per se, as described in the literature (for example in the standard works, such as Houben-Weyl, Methoden der organischen Chemie [Methods of Organic Chemistry], Georg-Thieme-Verlag, Stuttgart), to be precise under reaction conditions which are known and suitable for the said reactions. Use can also be made here of variants which are known per se, but are not men-tioned here in greater detail.

The starting materials, for example the compounds of the formula II and/or III, can, if desired, also be formed in situ by not isolating them from the reaction mixture, but instead immediately converting them further into the compound of the formula I.

The compound of the formula I can preferably be obtained by reacting compounds of the formula II with benzylpiperidine, phenoxypiperidine or derivatives thereof, in particular 4-(4-fluorobenzyl)piperidine, 4-(2,4-di-fluorobenzyl)piperidine or 4-(4-fluorophenoxy)piperidine.
The starting compounds of the formula II are generally novel. However, they can be prepared by methods known per se. The starting compounds of the formula III are either novel or known from the literature or commer-cially available. In any case, however, they can be prepared by methods known per se.

In the compounds of the formula II, L' is preferably Cl, Br, I, OH or a reac-tively modified OH group, in particular a reactively esterified OH group, such as an alkylsulfonyloxy group having 1-6 carbon atoms (preferably methylsulfonyloxy) or arylsulfonyloxy group having 6-10 carbon atoms (preferably phenyl- or p-tolylsulfonyloxy), or a diazonium group.
In the compounds of the formula III, L2 is preferably H or a group which activates the amino function, for example a metal ion. Suitable metal ions are, in particular, alkali metal, alkaline earth metal or aluminium ions.
Preferred metal ions are alkali metal ions, in particular Li, Na or K. In the case of polyvalent metal ions, a complex of metal ion and two or more compounds of the formula III often forms, where the complex generally comprises stoichiometrically as many compounds of the formula III as cor-responds to the valency of the metal ion.

The reaction of the compounds of the formula II with compounds of the formula III is generally carried out in an inert solvent, preferably in the presence of an acid-binding agent. Suitable acid-binding agents are all bases which are usual in synthetic organic chemistry, both inorganic and organic bases, preferably organic bases. Examples of suitable organic bases are triethylamine, diisopropylamine (DIPEA), dimethylaniline, pyri-dine and quinoline. The addition of an inorganic base, such as, for exam-ple, an alkali or alkaline earth metal hydroxide, carbonate or bicarbonate, or another salt of a weak acid of the alkali or alkaline earth metals, pref-erably of potassium, sodium, calcium or caesium, may also be favourable.

The reaction time is, depending on the conditions used, between a few minutes and 14 days, and the reaction temperature is between about -30 and 180 , normally between -20 and 140 , preferably between -10 and 130 and in particular between about 0 and about 120 . In many cases, it is favourable to carry out the reaction of a starting compound of the for-mula II with a starting compound of the formula III at comparatively high temperatures, for example at a temperature in the range from 70 to 130 , preferably from 80 to 120 and in particular from 90 to 110 , for example at about 100 . In a reaction in this temperature range, it is in many cases favourable to use an organic base, such as triethylamine or diisopropyl-amine, or preferably an inorganic base, such as sodium hydroxide, sodium carbonate and in particular sodium hydrogen carbonate.

Suitable inert solvents are, for example, hydrocarbons, such as hexane, petroleum ether, benzene, toluene or xylene; chlorinated hydrocarbons, such as trichloroethylene, 1,2-dichloroethane, tetrachloromethane, chloroform or dichloromethane; alcohols, such as methanol, ethanol, iso-propanol, n-propanol, n-butanol or tert-butanol; ethers, such as diethyl ether, diisopropyl ether, tetrahydrofuran (THF) or dioxane; glycol ethers, such as ethylene glycol monomethyl or monoethyl ether, ethylene glycol dimethyl ether (diglyme); ketones, such as acetone or butanone; amides, such as acetamide, dimethylacetamide or dimethylformamide (DMF);
nitriles, such as acetonitrile; sulfoxides, such as dimethyl sulfoxide (DMSO); carbon disulfide; carboxylic acids, such as formic acid or acetic acid; nitro compounds, such as nitromethane or nitrobenzene; esters, such as ethyl acetate, water, or mixtures of the said solvents.

The starting compounds of the formula II, in particular those in which Xis (CHR7)3 and preferably a propylene radical, i.e. CH2CH2CH2, can advanta-geously be prepared in a multistep synthesis sequence which starts from a compound of the formula VI

/E
D\ COOA VI
12'p In a first step, the ester group COOA of the compound of the formula VI is reduced to a hydroxymethyl group CH2-OH, for example using hydrides, preferably complex hydrides, such as lithium aluminium hydride. This gives a hydroxymethyl derivative of the formula VII

E
D\ CH2OH VII
N
( 2)P

which can be converted in a second step using an oxidant, such as, for example, manganese dioxide (Mn02), into an aldehyde derivative of the formula VIII
~E /
D\CHO VIII
N
R 2)P

The aldehyde derivative of the formula VIII be condensed in a third reac-tion step with an acetic acid derivative CH3-COOA, preferably ethyl acetate and in particular methyl acetate (aldol condensation). The condensation is preferably carried out under basic conditions, for example using alkoxides, such as sodium methoxide or sodium ethoxide, as base. This third step gives an acrylate derivative of the formula IX

E COOA
D\ IX
12)P

which can be hydrogenated in a fourth step to give a compound of the formula X

D X
/E :q(( CODA
N
12)P

for example in a hydrogen atmosphere in the presence of a platinum metal catalyst, such as, for example, palladium/carbon. The compound of the formula X can subsequently be reduced in a fifth step to an alcohol deriva-tive of the formula XI
/E
D\ OH XI
I (R12)P

Suitable reducing agents for this step are, for example, metal or boron hydrides and in particular complex hydrides, such as lithium aluminium hydride, and so-called deactivated complex hydrides, such as LiAI(OR)xH4,, in which Xis 1,2 or 3 and R are alkyl radicals having from 1 to of carbons. A deactivated complex hydride which is suitable for this reduction is commercially available under the name Vitride. The use of the so-called deactivated complex hydrides is particularly advantageous if it is desired to achieve selective reduction of the COOA group in the com-pound X to an alcohol group as in the formula XI in the presence of other groups which can be reduced by conventional hydrides, such as lithium aluminium hydride, such as, for example, nitrile groups. The compound XI
is an example of a compound of the formula II in which X is CH2CH2CH2 and L1 is OR A compound of the formula XI is preferably converted into a compound of the formula XII
O

D E _~/O-S-R XII
` Dq(f 12)P
R

in which the OH group is reactively esterified, for example by reaction with alkyl- or arylsulfonyl chlorides, preferably in the presence of a base, such as, for example, alkylamines and in particular triethylamine or diisopropyl-amine. The compounds of the formula XI or preferably of the formula XII
are subsequently reacted with a compound of the formula III in which L2 is preferably H to give a compound of the formula I, preferably in the pres-ence of a base, such as, for example, alkali metal hydroxides, alkali metal carbonates and in particular alkali metal hydrogencarbonates.

For the preparation of compounds of the formula I in which D-E is R2C=CR4 and R2 and/or R4 is CN, it is advantageous to start from com-pounds of the formula VI in which D-E is R2C=CR4 and R2 and/or R4 is H, and to convert these firstly, as described above, into compounds of the formulae VII, VII VIII and IX in which D-E is R2C=CR4 and R2 and/or R4 is H. The conversion of R2 and/or R4 from H into CN is then preferably carried out by firstly allowing dimethylformamide to react with phosphoryl chloride, adding a compound of the formula IX in which D-E is R2C=CR4 and R2 and/or R4 is H and in particular a compound of the formula IXa in which D-E is R2C=CR4 and R2 and R4 is H, allowing the reaction mixture to react, preferably at a temperature between 50 and 150 C and in particular from 80 to 130 C, preferably for a time in the range from ten minutes to two hours and in particular from 30 to 90 minutes. The reaction mixture is subsequently reacted with hydroxylammonium chloride (= hydroxylamine hydrochloride). The reaction with hydroxylammonium chloride is preferably carried out in a temperature range as described above and for a period of from 2 to 60 minutes and in particular from 5 to 30 minutes. For work-up, the reaction mixture is preferably hydrolysed, and the compound of the formula IX in which D-E is R2C=CR4 and R2 and/or R4 is CN, or, if a com-pound of the formula IXa has been employed, the compound of the for-mula lXb in which D-E is R2C=CR4 and R2 is H and R4 is CN is isolated by conventional methods which are familiar to the person skilled in the art.
H

CODA
R2 IXa N
(R12)P (compound IX where R1 D-E = R2C=CR4; R4 = H) 1. DMF/POCI3 2. NH2OH x HCI
NC
CODA
R2 IXb N
(R12) (compound IX where R1 p D-E = R2C=CR4; R4 = CN) The above process is particularly suitable for the conversion of compounds of the formula IX in which D-E is R2C=CR4 and R2 and R4 is H into compounds of the formula IX in which D-E is R2C=CR4, R2 is H and R4 is CN.

A base of the formula I can be converted into the associated acid-addition salt using an acid, for example by reaction of equivalent amounts of the base and the acid in an inert solvent, such as ethanol, followed by evapo-ration. Suitable acids for this reaction are, in particular, those which give physiologically acceptable salts. Thus, it is possible to use inorganic acids, for example sulfuric acid, nitric acid, hydrohalic acids, such as hydrochloric acid or hydrobromic acid, phosphoric acids, such as orthophosphoric acid, or sulfamic acid, furthermore organic acids, in particular aliphatic, alicyclic, araliphatic, aromatic or heterocyclic monobasic or polybasic carboxylic, sulfonic or sulfuric acids, for example formic acid, acetic acid, propionic acid, pivalic acid, diethylacetic acid, malonic acid, succinic acid, pimelic acid, fumaric acid, maleic acid, lactic acid, tartaric acid, malic acid, citric acid, gluconic acid, ascorbic acid, nicotinic acid, isonicotinic acid, methane-or ethanesulfonic acid, ethanedisulfonic acid, 2-hydroxyethanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, naphthalenemono- and -disulfonic acids, and laurylsulfuric acid. Salts with physiologically unacceptable acids, for example picrates, can be used for the isolation and/or purification of the compounds of the formula I.

The compounds according to the invention can be used as therapeutic agents, diagnostic agents and/or cosmetics or together with one or more active ingredients other than the compounds according to the invention and/or adjuvants in therapeutic agents, diagnostic agents and/or cosmet-ics. The compounds according to the invention are usually employed in the form of pharmaceutical, diagnostic and/or cosmetic formulations. For-mulations of this type and processes for the preparation thereof are known to the person skilled in the art.

Examples of formulations of this type are suspensions, emulsions, solu-tions, liposomes, salts, pastes, biodegradable polymers, nanoparticles, tablets, coated tablets, sugar-coated tablets, film-coated tablets, capsules, pills, granules, powders, aerosols, drops or sprays comprising at feast one compound according to the invention.

The compounds according to the invention or formulations which comprise at least one compound according to the invention can be administered to humans or animals, for example locally or systemically and in particular orally, intravenously, intraperitoneally, subcutaneously, transdermally, nasally, buccally and/or iontophoretically.

The invention furthermore relates to the use of the compounds of the for-mula I and/or physiologically acceptable salts thereof for the preparation of pharmaceutical preparations, in particular by non-chemical methods. They can be converted here into a suitable dosage form together with at least one solid, liquid and/or semi-liquid excipient or adjuvant and, if desired, in combination with one or more further active ingredients.

The invention furthermore relates to pharmaceutical preparations com-prising an effective amount of at least one of the compounds of the formula I and/or one of its physiologically acceptable salts thereof.
These preparations can be used as medicaments in human or veterinary medicine. Suitable excipients are organic or inorganic substances which are suitable for enteral (for example oral), parenteral or topical administra-tion or administration in the form of an inhalation spray and do not react with the novel compounds, for example water, vegetable oils, benzyl alco-hols, alkylene glycols, polyethylene glycols, glycerol triacetate, gelatine, carbohydrates, such as lactose or starch, magnesium stearate, talc or Vaseline. Suitable for oral administration are, in particular, tablets, pills, sugar-coated tablets, capsules, powders, granules, syrups, juices or drops, suitable for rectal administration are suppositories, suitable for parenteral administration are solutions, preferably oil-based or aqueous solutions, furthermore suspensions, emulsions or implants, and suitable for topical application are ointments, creams or powders. The novel compounds may also be lyophilised and the resultant Iyophilisates used, for example, to prepare injection preparations. The preparations indicated may be steril-ised and/or comprise adjuvants, such as lubricants, preservatives, stabi-lisers and/or wetting agents, emulsifying agents, salts for modifying the osmotic pressure, buffer substances, colorants and flavours and/or a plu-rality of further active ingredients, for example one or more vitamins.

For administration as an inhalation spray, it is possible to use sprays in which the active ingredient is either dissolved or suspended in a propellant gas or propellant gas mixture (for example CO2 or chlorofluorocarbons).
The active ingredient is advantageously used here in micronised form, in which case one or more additional physiologically tolerated solvents may be present, for example ethanol. Inhalation solutions can be administered with the aid of conventional inhalers.

The present invention therefore relates to a process for the preparation of pharmaceutical compositions which is characterised in that a compound of the formula I according to Claim 1 and/or one of its physiologically accept-able salts and/or solvates is converted into a suitable dosage form together with at least one solid, liquid or semi-liquid excipient or adjuvant.

The compounds of the formula I and/or physiologically acceptable salts thereof can be used as excitatory amino acid antagonists for combating diseases, in particular for combating neurodegenerative diseases, includ-ing cerebrovascular diseases, epilepsy, schizophrenia, Alzheimer's dis-ease, Parkinson's disease, Huntington's disease, cerebral ischaemia, infarction or psychoses.

The present invention therefore relates to the use of compounds of the formula I according to Claim 1 and/or physiologically acceptable salts or solvates thereof for the preparation of a medicament for the prophylaxis and/or treatment of schizophrenia, depression, dementia, Parkinson's dis-ease, Alzheimer's disease, Lewy bodies dementia, Huntington's disease, Tourette's syndrome, anxiety, learning and memory impairment, neuro-degenerative diseases and other cognitive impairments, as well as nicotine dependence and pain.

In general, the compounds according to the invention can be administered analogously to other known compounds having a similar action profile, such as, for example, ifenprodil, preferably in doses between about 0.05 and 500 mg, in particular between 0.5 and 100 mg, per dosage unit. The daily dose is preferably between about 0.01 and 2 mg/kg of body weight.
However, the specific dose for each patient depends on a wide variety of factors, for example on the efficacy of the specific compound employed, on the age, body weight, general state of health, sex, on the diet, on the time and method of administration, on the excretion rate, medicament combination and severity of the particular disease to which the therapy applies. Parenteral administration is preferred. Oral administration is particularly preferred.

The compounds according to the invention exhibit an advantageous action profile while being comparatively easy to prepare. Thus, in receptor bind-ing tests, compounds according to the invention exhibit an affinity to the ifenprodil binding site of the NMDA receptor, even in nanomolar concen-trations. In addition, the compounds according to the invention, as poly-amine antagonists which preferentially bind selectively to the NR2B
receptor of the NMDA sub-receptor class, are preferably distinguished by no or and only very slight elongation of the QT segment in the electro-cardiogram.

The compounds of the formula I and pharmaceutically usable prodrugs, derivatives, solvates, stereoisomers and salts thereof are particularly pref-erably suitable for the treatment of diseases of the central nervous system, such as states of tension, depression, anxiety states, schizophrenia, gastrointestinal tract disorders, nausea, tardive dyskinesia, Parkinson's disease and/or psychoses and of side effects in the treatment of hyper-tonia (for example using (x-methyldopa). The compounds can furthermore advantageously be used in endocrinology and gynaecology, for example for the therapy of acromegaly, hypogonadism, secondary amenorrhoea, premenstrual syndrome, undesired puerperal lactation, furthermore for the prophylaxis and therapy of cerebral disorders (for example migraine), in particular in geriatrics, in a similar way to certain ergot alkaloids.
The compounds according to the invention can also very particularly pref-erably be employed as therapeutic agents for combating the conse-quences of cerebral infarction (apoplexia cerebri), such as strokes and cerebral ischaemia, and for the treatment of brain and spinal cord trauma.

The compounds according to the invention are particularly suitable as medicament active ingredients for anxiolytics, antidepressants, anti-psychotics, neuroleptics, antihypertonics and/or for positively influencing obsessive-compulsive disorder (OCD), sleeping disorders, tardive dys-kinesia, learning disorders, age-related memory disorders, eating dis-orders, such as bulimia, and/or sexual dysfunctions.

For the above-mentioned indications/areas of application, preferably for the indications/areas of application mentioned in the two preceding para-graphs, the substances according to the invention are generally adminis-tered analogously to known commercially available preparations (for example citalopram and fluoxetine), preferably in doses of between about 0.2 and 500 mg, in particular between 0.2 and 50 mg, per dosage unit. The daily dose is preferably between about 0.001 and 10 mg/kg of body weight.
The low doses are between about 0.2 and 500 mg, in particular between 0.2 and 50 mg, per dosage unit. The low doses (from about 0.2 to 1 mg per dosage unit; from about 0.001 to 0.005 mg/kg of body weight) are particularly suitable for use as migraine agents; for the other indications, doses of between 10 and 50 mg per dosage unit are preferred. However, the specific dose for each particular patient depends on a very wide variety of factors, for example on the efficacy of the specific compound employed, on the age, body weight, general state of health, sex, on the diet, on the time and method of administration, on the excretion rate, medicament combination and severity of the particular disease to which the therapy applies. Oral administration is preferred for the above-mentioned indications.
Above and below, all temperatures are given in C. In the following exam-ples, "conventional work-up" means that water is added if necessary, the pH is adjusted, if necessary, to between 2 and 10, depending on the con-stitution of the end product, the mixture is extracted with ethyl acetate or dichloromethane, the phases are separated, if necessary the organic phase is dried, for example over sodium sulfate, the organic phase is evaporated, and the residue obtained is purified by chromatography, for example on silica gel, and/or by crystallisation.

Example 1 Preparation of 4-{3-[4-(fluorobenzyl)piperidin-1-yl]propyl}-1 H-indole-3-carbonitrile (= EMD 432517) 1.1. Step a: preparation of 4-hydroxymethylindole (2) A solution of 25 g of methyl 4-indolecarboxylate (1) in 200 ml of tetrahydrofuran is added to a suspension of LiAIH4 in 100 ml of tetrahydrofuran under a protective-gas atmosphere (N2) at such a rate that the temperature of the reaction mixture does not exceed 40 C. When the addition is complete, the reaction mixture is stirred at room temperature (25 C) for approximately two further hours until the methyl 4-indolecarboxylate has reacted completely. The reac-tion mixture is subsequently hydrolysed by addition of ice-water (about 100 ml), and the hydrolysate is filtered through a bed of kieseiguhr. After the tetrahydrofuran has been removed by distilla-tion, the aqueous phase obtained is extracted with ethyl acetate.
The organic phase obtained is dried over magnesium sulfate and evaporated, giving 16.0 g (76% of theory) of a pale-beige crystalline residue of 4-hydroxymethylindole (2).
1.2. Step b: preparation of 4-formylindole (3) Manganese dioxide (Mn02) is added slowly with stirring to a solution of 74 g of 4-hydroxymethylindole (2) in 3 litres of dichloromethane, and the mixture is subsequently stirred at room temperature for 72 hours. The reaction mixture is subsequently filtered through kieselguhr, and the filtrate is evaporated. The crystalline residue obtained is stirred with cyclohexane and filtered under reduced pressure. Drying gives 63 g (86% of theory) of crystalline 4-formylindole (3).

1.3. Step c: preparation of methyl 3-(1 H-indol-4-yl)acrylate (4) 48 g of sodium methoxide are added to 300 ml of tetrahydrofuran with stirring at 5 C under a protective gas (N2), the suspension is cooled to 0 C, 70 ml of methyl acetate are added dropwise at from 0 to 3 C, and the mixture is stirred at this temperature for a further 45 minutes. A solution of 43 g of 4-formylindole (3) in 300 ml of tetrahydrofuran is subsequently added with stirring, during which the temperature does not exceed 3 C. The mixture is subsequently stirred at room temperature for a further two hours. For work-up, the reaction mixture is evaporated, and the residue is dissolved in methyl acetate and extracted with water. The organic phase obtained is dried, the solvent is removed under reduced pressure, and the residue is purified by chromatography on silica gel, giving g (59% of theory) of a pale-beige crystalline residue of methyl 3-(1 H-indol-4-yl)acrylate (4).

1.4. Step d: preparation of indolecarbonitrile 5 Phosphoryl chloride is added dropwise with cooling in an ice bath to 100 ml of dimethylformamide at such a rate that the temperature of the mixture is from about 20 to 30 C. A solution of 25 g of 3-(1 H-indol-4-yl)acrylic acid in 100 ml of dimethylformamide is subse-quently added dropwise at room temperature, during which the temperature rises to 60 C. The mixture is subsequently stirred at 125 C for one hour. A warm solution of 17.2 g of hydroxylammo-nium chloride in 100 ml of dimethylformamide is then added, and the mixture is stirred at 120 C for a further 15 minutes. The reaction mixture is cooled to room temperature and added dropwise with stir-ring to ice-water, whereupon beige crystals precipitate. The mixture is stirred for a further two hours and filtered, and the crystalline residue is dried overnight at 120 C under reduced pressure, giving 23.5 g (84% of theory) of a pale-beige crystalline residue of indole-carbonitrile 5.

1.5. Step e: preparation of compound 6 5 g of indolecarbonitrile 5 are dissolved in methanol under a pro-tective-gas atmosphere (N2), palladium on active carbon (Pd/C) is added, and the mixture is hydrogenated at room temperature under atmospheric pressure with hydrogen until the reaction is complete.
For work-up, the reaction mixture is filtered, and the filtrate is freed from solvent under reduced pressure. The residue is taken up in methyl acetate and extracted with water. The organic phase is separated off, dried and evaporated. The residue is purified by chromatography on silica gel using ethyl acetate as eluent, giving 4.2 g (84% of theory) of a beige crystalline residue of compound 6.
1.6. Step f: preparation of compound 7 18.2 g of compound 6 are dissolved in 1000 ml of tetrahydrofuran under a protective-gas atmosphere, and the solution is cooled to 0 C. A solution of 60 mi of VitrideTM in 60 ml of toluene is subse-quently added dropwise at such a rate that the temperature remains in the range from 2 to 8 C, and the mixture is stirred at 5 C for a further three hours. During the addition of the Vitride,~ a precipitate may form, which, however, generally re-dissolves on subsequent stirring. Excess VitrideTM is hydrolysed by addition of 250 ml of water, during which a precipitate may form. A further 200 ml of water and 300 ml of ethyl acetate are added, and the mixture is left to stand overnight. The reaction mixture is subsequently filtered through kieselguhr, the residue is discarded, and the filtrate phases are separated. The organic phase is freed from solvent under reduced pressure and purified by chromatography on silica gel using ethyl acetate as eluent, giving 13.5 g (84% of theory) of a beige crystal-line residue of compound 7.

1.7. Step g: preparation of compound 8 A solution of 6 g of compound 7 in 80 ml of dichloromethane and 80 ml of tetrahydrofuran is cooled to 2 C. 2.3 ml of methanesulfonyl chloride are added, the mixture is stirred briefly, and 5.3 ml of triethylamine are subsequently added at from 2 to 5 C. The mixture is subsequently stirred at 2 C for a further 2 hours. The reaction mixture is then poured into ice-water, the aqueous phase is extracted, and the combined organic phases are freed from solvent under reduced pressure, giving 7.6 g (91 % of theory) of a brown crystalline residue of compound 8.

1.8. Step h: preparation of compound 10 0.40 gram of 4-(4-fluorobenzyl)piperidine (9) and 0.42 gram of sodium hydrogencarbonate are added to a suspension of 0.50 gram of compound 8 in 10 ml of acetonitrile with stirring, and the mixture is stirred at 100 C for 24 hours. The reaction mixture is subse-quently cooled to room temperature, and the solvent is removed under reduced pressure. The residue obtained is purified by chromatography on silica gel and dissolved in acetone, and ethereal hydrochloric acid is added. The crystalline precipitate which forms is separated off by filtration and dried, giving 230 mg (35% of theory) of compound 10 (4-{3-[4-(4-fluorobe nzyl)-1-piperidyl]propyl}-1H-indole-3-carbonitrile as the hydrochloride.

The following formula scheme relates to the preparation of 4-{3-[4-(4-fluorobenzyl)-1-piperidyl]propyl}-1 H-indole-3-carbonitrile in accordance with Example 1. The lower-case letters a to h on the reaction arrows cor-respond to reaction steps a to h described above.
HC 'o O HO H O

N N N
H H H

O
O
H3C;-0 H3C-0 H3C-0 e \\ I

N H H
H

f H H

F h NH

,ON N
F

N
H
Example 2 Process steps a' to g': preparation of compound 18 Compound 18 was obtained analogously to the reaction sequence carried out in Example 1 in reaction steps a to g in accordance with the following formula scheme in reaction steps a' to h'.

O I\ a HO b H

H H H

C.

H3c'0 H3c,0 ~ H3c,0 d' I

H H
H

f O
II N/
N
HO H3c~ ko N N
H H

5-{4-[3-(3-Cyano-1 H-indol-5-yl)propyl]piperazin-1-yl}benzofuran-2-carboxamide 20 can be obtained analogously to process step h of Exam-ple 1 in accordance with the following conditions by reaction of compound 18 with compound 19:
Step h': preparation of compound 20 H3C"S~ O HN
0 + N 0 18 / N O NHz H

N

H
N N 10'0~NH2 15 0.90 g of 5-piperazin-1-ylbenzofuran-2-carboxamide (19) and 1.4 g of ethyldiisopropylamine (DIPEA) are added with stirring to a suspension of 1.00 gram of compound 18 in 30 ml of acetonitrile, and the mixture is refluxed for 18 hours. The reaction mixture is subsequently cooled to room temperature, methanol (20 ml) is added, and the mixture is refluxed for a 20 further three hours. The solvent is subsequently removed under reduced pressure, and the residue is purified by chromatography on silica gel. The residue obtained is dissolved in acetone, and ethereal hydrochloric acid is added. The crystalline precipitate which forms is separated off by filtration and dried, giving 0.4 g (22% of theory) of the compound 5-{4-[3-(3-cyano-1 H-indol-5-yl)propyl]piperazin-1 -yl}benzofuran-2-carboxamide 20 as the hydrochloride.

Example 3 The following compounds can be obtained analogously to the process described in Example 1 or Example 2:

5-{3-[4-(4-Cyanophenyl)piperazin-1-yl]propyl}-1 H-indole-3-carbonitrile (21);
5-{4-[3-(3-Cyano-1 H-indol-6-yl)propyl]piperazin-1-yl}benzofuran-2-carboxamide (22);
5-{3-[4-(2-Oxo-2H-chromen-6-yl)piperazin-1-yl]propyl}-1 H-indole-3-carbonitrile (23);
5-{4-[3-(3-Cyano-1 H-indol-4-yl)propyl]piperazin-1-yl}benzofuran-2-carboxamide (24);
5-{3-[4-(1 H-Indol-4-yl)piperazin-1-yl]propyl}-1-methanesulfonyl-1 H-indole-3-carbonitrile (25);
5-[3-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)propyl]-1 H-indole-3-carbonitrile (26);
5-[3-(4-Benzo[1,2,5]thiadiazol-4-ylpiperazin-1-yl)propyl]-1 H-indole-3-carbonitrile (27);
3-{1 -[3-(3-Cyano-1 H-indol-5-yl)propyl]piperidin-4-yl}-1 H-indole-5-carboxamide (28);
5-[3-(4-Quinolin-8-ylpiperazin-1-yl)propyl]-1 H-indole-3-carbonitrile (29);
5-{3-[4-(2,3-Dihydrobenzo[1,4]dioxin-5-yl)piperazin-1-yl]propyl}-1 H-indole-3-carbonitrile (30);
1-Methanesulfonyl-5-[3-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)propyl]-1 H-indole-3-carbonitrile (31);
5-{3-[4-(1 H-Indol-4-yl)piperazin-1-yl]propyl}-1 H-indole-3-carbonitrile (32);
5-{3-[4-(1 H-Indol-3-yi)piperidin-1-yl]propyl}-1 H-indole-3-carbonitrile (33);
5-{3-[4-(5-Fluoro-1 H-indol-3-yl)piperidin-1 -yi]propyl}-1 H-indole-3-carbonitrile (34);
3-{1-[3-(3-Cyano-1 H-indol-5-yl)propyl]piperidin-4-yl}-1 H-indole-5-carbonitrile (35);

5-{3-[4-(6-Fluoro-1 H-indol-3-yl)piperidin-l-yl]propyl}-1 H-indole-3-carbonitrile (36);
5-{3-[4-(4-Fluoro-1 H-indol-3-yl)piperidin-1-yl]propyl}-1 H-indole-3-carbonitrile (37);
5-[3-(4-Benzo[d]isothiazol-3-ylpiperazin-1-yl)propyl]-1 H-indole-3-carbonitrile (38);
4-{1-[3-(3-Cyano-1 H-indol-6-yl)propyl]piperidin-4-yloxy}-benzamide (39);
6-{3-[4-(2-Cyano-3-methoxyphenyl)piperazin-l-yl]propyl}-1 H-indole-3-carbonitrile (40);
6-{3-[4-(4-Cyano-3-methoxyphenyl)piperazin-1-yl]propyl}-1 H-indole-3-carbonitrile (41);
6-{3-[4-(4-Cyano-2-methoxyphenyl)piperazin-1-yl]propyl}-1 H-indole-3-carbonitrile (42);
4-[3-(4-PYrazol-1-YlmethYl-1-piperidY1)proPY]I -1 H-indole-3-carbonitrile (43);
6-{3-[4-(4-Fluorobenzyl)-1-piperidyl]propyl}-1 H-indole-3-carbonitrile (44);
6-{3-[4-(2,4-Difluorobenzyl)-1-piperidyl]propyl}-1 H-indole-3-carbo-nitrile (45);
6-{3-[4-(4-Fluorophenoxy)-1-piperidyl]propyl}-1 H-indole-3-carbonitrile (46);
4-{3-[4-(2,4-Difluorobenzyl)-1-piperidyl]propyl}-1 H-indole-3-carbo-nitrile (47);
4-{3-[4-(4-Fluorophenoxy)-1-piperidyl]propyl}-1 H-indole-3-carbonitrile (48);
5-{3-[4-(4-Fluorophenoxy)-1-piperidyl]propyl}-1 H-indole-3-carbonitrile (49);
5-{3-[4-(4-Fluorobenzyl)-1-piperidyl]propyl}-1 H-indole-3-carbonitrile (50);
5-{3-[4-(2,4-Difluorobenzyl)-1-piperidyl]propyl}-1 H-indole-3-carbo-nitrile (51).

The compounds can be purified and/or characterised by HPLC chromatog-raphy. The characterisation of the compounds via the retention time (Rt) can be carried out on a 3 p Silica-Rod column with a 210 second gradient from 20 to 100% water/acetonitrile/0.01 % trifluoroacetic acid at a flow rate of 2.2 ml/minute and detection at a wavelength of 220 nanometres.
Physical constants and analytical data (mass spectrometric data (HPLC-MS)) of compounds 20-43 synthesised as above are shown in Table I.
Table I

Com- Structure MW [M+H] Rt(HPLC) pound g/mol HPLC-MS /min \N~
Fi O 4"N

21 ;X 370 N \-/ N&-=N
N
H
22 N~ C/0 429 N i / NJ

23 % 0 413 ~ N~N O
NI /
24 N\ 429 N
N
/ \ ~
N
\ O NHZ

25 N i NH 463 \

N
0_ /
H,C-S11 O
26 NX a H 415 N
N N

H

NON
H N/`N
S

28 o NHZ 426 N

N
NH
N
H
29 ~ 397 / \

H N\ /

H
H
N
NH
i N ~
O~~ I
H,CS\\ N
O
32 N i NH 384 N/ N
N
H

/ \ N
N
H / I \
N
H

/ \ N

H F
N
H

N
N N

N
H

N
\
N /
H
N F
H

/ \ N
F
N
H / I \
H
38 \X 403 \ N
N "
H / \
N
39 N% 403 ~N I / N I / O
H

N/ I rN \ 0 N / N~~//II I I CH3 H N
41 " 400 pp N ~N CH3 H

N/ rN

43 r~1_ 348 N

N/
N
H

Physical constants and analytical data (mass spectrometric data (FAB-MS) and retention times (HPLC)) of compounds 10 and 44-51 synthesised as above are shown in Table II.
Table II

Com- Structure MW [M+H] Rt(HPLC) pound g/mol HPLC-MS /min 375.49 376.20 1.428 F
N N

44 N 375.49 376 1.203 N / " F

10 45 F 393.48 394 1.236 N
N

46 N N )O 'F 377.47 378 1.172 N
47 F 393.48 394 1.443 F
N/ /
N

48 N \ I 377.47 378 1.347 F
N ~

N

49 N% " / F 394 F

50 " " / F 376 N
N
51 N I% N~O \ F 378 The examples below relate to pharmaceutical compositions:

Example A: Injection vials A solution of 100 g of the active ingredient of the formula I and 5 g of diso-dium hydrogenphosphate in 3 I of bidistilled water is adjusted to pH 6.5 using 2N hydrochloric acid, sterile filtered, transferred into injection vials, lyophilised under sterile conditions and sealed under sterile conditions.
Each injection vial contains 5 mg of active ingredient.

Example B: Suppositories A mixture of 20 g of the active ingredient of the formula I is melted with 100 g of soya lecithin and 1400 g of cocoa butter, poured into moulds and allowed to cool. Each suppository contains 20 mg of active ingredient.
Example C: Solution A solution is prepared from 1 g of the active ingredient of the formula I, 9.38 g of NaH2PO4 - 2 H2O, 28.48 g of Na2HPO4 = 12 H2O and 0.1 g of benzalkonium chloride in 940 ml of bidistilled water. The pH is adjusted to 6.8, and the solution is made up to I I and sterilised by irradiation. This solution can be used in the form of eye drops.

Example D: Ointment 500 mg of the active ingredient of the formula I are mixed with 99.5 g of Vaseline under aseptic conditions.
Example E: Tablets A mixture of 1 kg of active ingredient of the formula I, 4 kg of lactose, 1.2 kg of potato starch, 0.2 kg of talc and 0.1 kg of magnesium stearate is pressed to give tablets in a conventional manner in such a way that each tablet contains 10 mg of active ingredient.

Example F: Coated tablets Tablets are pressed analogously to Example E and subsequently coated in a conventional manner with a coating of sucrose, potato starch, talc, tragacanth and dye.

Example G: Capsules 2 kg of active ingredient of the formula I are introduced into hard gelatine capsules in a conventional manner in such a way that each capsule con-tains 20 mg of the active ingredient.

Example H: Ampoules A solution of 1 kg of active ingredient of the formula I in 60 I of bidistilled water is sterile filtered, transferred into ampoules, lyophilised under sterile conditions and sealed under sterile conditions. Each ampoule contains 10 mg of active ingredient.

Example I: Inhalation spray 14 g of active ingredient of the formula I are dissolved in 10 I of isotonic NaCl solution, and the solution is transferred into commercially available spray containers with a pump mechanism. The solution can be sprayed into the mouth or nose. One spray shot (about 0.1 ml) corresponds to a dose of about 0.14 mg.

Claims (19)

CLAIMS:
1. A compound of formula Ia, or a pharmaceutically usable salt, solvate or stereoisomer or a mixture thereof, in which R1 is H, A or SO2A, A is straight-chain alkyl having from 1 to 4 carbon atoms or branched alkyl having from 3 to 6 carbon atoms, D-E is R2C=CR4, R2 is selected from H, A and cycloalkyl having from 3 to 7 carbon atoms, R4 is Hal, CH2HaI, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)nCOOR6, (CH2)nCON(R6)2, (CH2)nNR6COR6, (CH2)nNR6CON(R6)2, (CH2)nNR6SO2A, (CH2)nSO2N(R6)2, (CH2)nS(O)wA, (CH2)nOOCR6, (CH2)nCOR6, (CH2)nCO(CH2)mAr, (CH2)nCO(CH2)mHet, (CH2)nCOO(CH2)mAr, (CH2)nCOO(CH2)mHet, (CH2)nOR6, (CH2)nO(CH2)mAr, (CH2)nO(CH2)mHet, (CH2)nSR6, (CH2)nS(CH2)mAr, (CH2)nS(CH2)mHet, (CH2)nN(R6)(CH2)mAr, (CH2)nN(R6)(CH2)mHet, (CH2)nSO2N(R6)(CH2)mAr, (CH2)nN(R6)SO2(CH2)mAr, (CH2)nSO2N(R6)(CH2)mHet, (CH2)nN(R6)SO2(CH2)mHet, (CH2)nCON(R6)(CH2)mAr, (CH2)nN(R6)CO(CH2)mAr, (CH2)nCON(R6)(CH2)mHet, (CH2)nN(R6)CO(CH2)mHet, (CH2)nN(R6)2, (CH2)nOCOR6, (CH2)nOC(O)N(R6)2, (CH2)nOC(O)NR6(CH2)mAr, (CH2)nOC(O)NR6(CH2)mHet, (CH2)nNR6COOR6, (CH2)nNR 6COO(CH2)mAr, (CH2)nNR6COO(CH2)mHet, (CH2)nN(R6)CH2CH2OR6, (CH2)nN(R6)CH2CH2OCF3, (CH2)n N(R6)C(R6)HCOOR6, (CH2)n N(R6)CH2COHet, (CH2)n N(R6)CH2Het, (CH2)n N(R6)CH2CH2N(R6)CH2COOR6, (CH2)n N(R6)CH2CH2N(R6)2, CH=CHCOOR6, (CH2)n N(COOR6)COOR6, (CH2),N(CONH2)COOR6, (CH2)n N(CONH2)CONH2, (CH2),N(CH2COOR6)COOR6, (CH2)n N(CH2CONH2)COOR6, (CH2)n N(CH2CONH2)CONH2, (CH2)n CHR6COR6, (CH2)n CHR6COOR6 or (CH2)n CHR6CH2OR6, Het is a saturated, unsaturated or aromatic mono- or bicyclic heterocyclic radical which is unsubstituted or mono- or polysubstituted by A, Hal, NO2, ON, OR6, N(R6)2, COOR6, CON(R6)2, NR6COR6, NR6CON(R6)2, NR6SO2A, COR6, SO2N(R6)2, S(O),A and/or OOCR6, Ar is an aromatic hydrocarbon radical having from 6 to 14 carbon atoms which is unsubstituted or mono- or polysubstituted by A, Hal, NO2, CN, OR6, N(R6)2, COOR6, CON(R6)2, NR6COR6, NR6CON(R6)2, NR6SO2A, COR6, SO2N(R6)2, S(O)w A and/or OOCR6, w is 0, 1, 2 or 3, m is 0, 1, 2, 3, 4 or 5, n is 0,1,2 or 3, X1 is (CHR7)g, g is 2,3,4 or 5, R6 is selected independently of one another from H, A or cycloalkyl having 3 to 7 carbon atoms, R7, R8, R9 and R10, independently from one another, are as defined for R2 or R4, Y is CH, N, COR11, CSR11, an unsubstituted or substituted, spiro-linked carbocyclic radical having from 5 to 7 carbon atoms or an unsubstituted or substituted, spiro-linked, 5-, 6- or 7-membered heterocyclic radical having from 1 to 3 heteroatoms selected from N, S or O, R11 is H, A, (CH2)nHet, (CH2)nAr or cycloalkyl having from 3 to 7 carbon atoms, X2 is a bond or selected from O, S, N-R7, CH2 or CH2CH2, p, q and r, independently of one another, are 0, 1, 2 or 3, Hal is F, Cl, Br or I, R12 and R13, independently of one another, are selected from Hal, CN, NO2, OR6, N(R6)2, NO2, CN, COOR6, CON(R6)2, NR6COR6, NR6CON(R6)2, NR6SO2A, COR6, SO2NR6, S(O)wA, OOCR6 and/or C(NH)NOH, and Z is H or is a saturated, mono- or polyethylenically unsaturated or aromatic carbocyclic radical having from 5 to 10 carbon atoms or a saturated, mono- or polyethylenically unsaturated or aromatic heterocyclic radical having from 4 to 9 carbon atoms, where the carbocyclic or heterocyclic radical may be mono- or polysubstituted, where the substituents are selected, independently of one another, from the meanings of R2 to R5 other than H, and where the heterocyclic radical contains from 1 to 4 heteroatoms selected, independently of one another, from N, O and S.
2. A compound of formula la according to Claim 1, or a pharmaceutically usable salt, solvate or stereoisomer or a mixture thereof, in which R1 is H or SO2A, D-E is R2C=CR4, R2 is H, alkyl having from 1 to 3 carbon atoms, alkoxyalkyl having from 2 to 5 carbon atoms, Hal, CH2HaI, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)nCOOR6, (CH2)nCON(R6)2, (CH2)nSO2N(R6)2 or (CH2)nS(O)wR6, R4 is H, alkyl having from 1 to 3 carbon atoms, alkoxyalkyl having 2 to 5 carbon atoms, Hal, CH2HaI, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, (CH2)nCOOR6, (CH2)nCON(R6)2, (CH2)nSO2N(R6)2, or (CH2)nS(O)wR6, R6 is H or A, n is 0 or 1, X1 is (CHR7)g, in which g is 2, 3 or 4, Y is CH, COR11, N or an unsubstituted or substituted, spiro-linked 5-, 6- or 7-membered heterocyclic radical having from 1 to 3 heteroatoms selected from N, S or O, R11 is H or A, X2 is CH2, CH2CH2, HCOH, O, S, N-R6, CONR6, C=O or a bond, and R12, independently of one another, is selected from A, Hal, CN, NO2, OR6, N(R6)2, COOR6, CON(R6)2, COR6, SO2N(R6)2 and S(O)wA.
3. A compound of formula la according to Claim 1 or a pharmaceutically usable salt, solvate or stereoisomer or a mixture thereof, in which the group X2-Z is:

in which R14, independently from one another, is selected from Hal, A, NO2, OR6, N(R6)2, CN, COOR6, CON(R6)2, NR6COR6, NR6CON(R6)2, NR6SO2A, COR6, SO2NR6, S(O)wA, OOCR6 and/or C(NH)NOH, w is 0, 1, 2 or 3, t is 0, 1, 2 or 3, and R' is H, A, (CH2)nHet, (CH2)nAr, cycloalkyl having from 3 to 7 carbon atoms, or SO2A.
4. A compound of formula la according to Claim 1, 2 or 3, which is:
a) 6-{3-[4-(4-fluorobenzyl)-1-piperidiyl]-propyl}-1H-indol-3-carbonitrile;

b) 6-{3-[4-(2,4-difluorobenzyl)-1-piperidiyl]-propyl}-1H-indol-3-carbonitrile;

c) 6-{3-[4-(4-fluorophenoxy)-1-piperidiyl]-propyl}-1H-indol-3-carbonitrile;

d) 4-{3-[4-(4-fluorobenzyl)-1-piperidiyl]-propyl}-1H-indol-3-carbonitrile;

e) 4-{3-[4-(2,4-difluorobenzyl)-1-piperidiyl]-propyl}-1H-indol-3-carbonitrile;

f) 4-{3-[4-(4-fluorophenoxy)-1-piperidiyl]-propyl}-1H-indol-3-carbonitrile;

g) 5-{3-[4-(4-fluorophenoxy)-1-piperidiyl]-propyl}-1H-indol-3-carbonitrile;

h) 5-{3-[4-(4-fluorobenzyl)-1-piperidiyl]-propyl}-1H-indol-3-carbonitrile;

i) 5-{3-[4-(2,4-difluorobenzyl)-1-piperidiyl]-propyl}-1H-indol-3-carbonitrile;

j) 5-{3-[4-(4-cyano-phenyl)-piperazin-1-yl]-propyl}-1H-indol-3-carbonitrile;

k) 5-{4-[3-(3-cyano-1H-indol-6-yl)-propyl]-piperazin-1-yl}-benzofuran-2-carboxamide;

I) 5-{3-[4-(2-oxo-2H-chromen-6-yl)-piperazin-1-yl]-propyl}-1H-indol-3-carbonitrile;

m) 5-{4-[3-(3-cyano-1H-indol-4-yl)-propyl]-piperazin-1-yl}-benzofuran-2-carboxamide;

n) 5-{4-[3-(3-cyano-1H-indol-5-yl)-propyl]-piperazin-1-yl}-benzofuran-2-carboxamide;

o) 5-{3-[4-(1H-indol-4-yl)-piperazin-1-yl]-propyl}-1-methanesulfonyl-1H-indol-3-carbonitrile;

p) 5-[3-(4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-yl)propyl]-1H-indol-3-carbonitrile;

q) 5-[3-(4-benzo[1,2,5]thiadiazol-4-yl-piperazin-1-yl)-propyl]-1H-indol-3-carbonitrile;

r) 3-{1-[3-(3-cyano-1H-indol-5-yl)-propyl]-piperidin-4-yl}-1H-indol-5-carboxamide;

s) 5-[3-(4-chinolin-8-ylpiperazin-1-yl)-propyl]-1H-indol-3-carbonitrile;
t) 5-{3-[4-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-piperazin-1-yl]-propyl}-1H-indol-3-carbonitrile;

u) 1-methanesulfonyl-5-[3-(4-oxo-1-phenyl-1,3,8-triaza-spiro[4.5]dec-8-yI)propyl]-1H-indol-3-carbonitrile;

v) 5-{3-[4-(1H-indol-4-yl)-piperazin-1-yl]-propyl}-1H-indol-3-carbonitrile;

w) 5-{3-[4-(1H-indol-3-yl)-piperidin-1 -yl]-propyl}-1H-indol-3-carbonitrile;

x) 5-{3-[4-(5-fluoro-1H-indol-3-yl)-piperidin-1-yl]-propyl}-1H-indol-3-carbonitrile;

y) 3-{1-[3-(3-cyano-1H-indol-5-yl)-propyl]-piperidin-4-yl}-1H-indol-5-carbonitrile;

z) 5-{3-[4-(6-fluoro-1H-indol-3-yl)-piperidin-1-yl]-propyl}-1H-indol-3-carbonitrile;

aa) 5-{3-[4-(4-fluoro-1H-indol-3-yl)-piperidin-1-yl]-propyl}-1H-indol-3-carbonitrile;

bb) 5-[3-(4-benzo[d]isothiazol-3-yl-piperazin-1 -yl)-propyl]-1H-indol-3-carbonitrile;

cc) 4-{1-[3-(3-cyano-1H-indol-6-yl)-propyl]-piperidin-4-yloxy}-benzamide;

dd) 6-{3-[4-(2-cyano-3-methoxy-phenyl)-piperazin-1-yl]-propyl}-1H-indol-3-carbonitrile;

ee) 6-{3-[4-(4-cyano-3-methoxy-phenyl)-piperazin-1-yl]-propyl}-1H-indol-3-carbonitrile;

ff) 6-{3-[4-(4-cyano-2-methoxy-phenyl)-piperazin-1-yl]-propyl}-1H-indol-3-carbonitrile;

gg) 4-[3-(4-pyrazol-1-ylmethyl-1-piperidyl)-propyl]-1H-indol-3-carbonitrile, hh) N-(6-{4-[3-(3-cyano-1H-indol-5-yl)-propyl]-piperazin-1-yl}-2-oxo-2H-chromen-3-yl)-acetamide, ii) 5-{3-[(pyridin-3-ylmethyl)-amino]-propyl}-1H-indol-3-carbonitrile, jj) 5-{3-[4-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-piperazin-1-yl]-propyl}-1H-indol-3-carbonitrile, kk) 5-[3-(4-pyrimidin-2-yl-piperazin-1-yl)-propyl]-1H-indol-3-carbonitrile, II) 5-{3-[4-(3-methoxy-phenyl)-3-methyl-piperazin-1-yl]-propyl}-1H-indol-3-carbonitrile, mm) 5-{3-[4-(1-methyl-1H-imidazo[4,5-c]pyridin-4-yl)-piperazin-1-yl]-propyl}-1H-indol-3-carbonitrile, nn) N-(4-{1-[3-(3-cyano-1H-indol-5-yl)-propyl]-piperidin-4-ylmethyl}-phenyl)-acetamide, oo) 5-{3-[4-(4-pyridin-3-yl-thiazol-2-yl)-piperazin-1-yl]-propyl}-1H-indol-3-carbonitrile, pp) ethyl 2-{4-[3-(3-cyano-1H-indol-5-yl)-propyl]-piperazin-1-yl}-thiazol-4-carboxylate, qq) 5-{3-[3-(2-oxo-pyrrolidin-1-yl)-propylamino]-propyl}-1H-indol-3-carbonitrile, rr) 5-{3-[4-(3-amino-2-oxo-2H-chromen-6-yl)-piperazin-1-yl]-propyl}-1H-indol-3-carbonitrile, ss) methyl (6-{4-[3-(3-cyano-1H-indol-5-yl)propyl]piperazin-1-yl}-2-oxo-2H-chromen-3-yl)carbamate, tt) 2-{4-[3-(3-cyano-1H-indol-5-yl)-propyl]-piperazin-1-yl}-thiazol-4-carboxamide, or uu) 4-[3-(3-cyano-1H-indol-5-yl)-propyl]-piperazine-1-thio-carboxamide;

or a salt or solvate thereof.
5. Process for the preparation of a compound of formula la according to Claim 1, characterised in that a) a compound of the formula II

in which L1 is Cl, Br, I, OH, a reactively esterified OH group, selected from an alkylsulphonyloxy group having 1-6 carbon atoms or an arylsulfonyloxy group having 6-10 carbon atoms, or a diazonium group, and in which R1, D, E, R12, p and X1 are as defined in Claim 1, b) is reacted with a compound of the formula III, in which L2 is H or a metal ion, and in which q, y, X2 and Z are as defined in Claim 1.
6. Process for the preparation of a pharmaceutical composition, characterised in that a compound of the formula I according to any one of Claims 1 to 4 and/or one of its physiologically acceptable salts is converted into a suitable dosage form together with at least one solid, liquid or semi-liquid excipient or adjuvant.
7. Pharmaceutical composition, characterised by a content of at least one compound of the formula I according to any one of Claims 1 to 4 and/or one of its physiologically acceptable salts and/or one of its solvates; and at least one solid, liquid or semi-liquid excipient or adjuvant.
8. A compound of formula I according to any one of Claims 1 to 4 or a physiologically acceptable salt or solvate thereof as a medicament.
9. A compound of formula I according to any one of Claims 1 to 4 and/or a physiologically acceptable salt thereof as an excitatory amino acid antagonist.
10. A compound of formula I according to any one of Claims 1 to 4 or a physiologically acceptable salt or solvate thereof as a glycine transporter inhibitor.
11. A compound of formula I according to any one of Claims 1 to 4 or a physiologically acceptable salt thereof as an excitatory amino acid antagonist for combating a neurodegenerative disease, a cerebrovascular disease, epilepsy, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's disease, cerebral ischaemia, infarction or a psychosis.
12. Use of the compound of formula I according to any one of Claims 1 to 4 for the preparation of a medicament for the prophylaxis and/or therapy of a disease in which 5HT plays a role.
13. Use of Claim 12, characterised in that the disease is depression, a stroke, cerebral ischaemia, an extrapyramidal motor side effect of neuroleptics or of Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, brain or spinal cord trauma, obsessive-compulsive disorder, a sleeping disorder, tardive dyskinesia, a learning disorder, an age-related memory disorder, an eating disorder, bulimia, and/or a sexual dysfunction.
14. Use of a compound of formula I according to any one of Claims 1 to 4 and/or a physiologically acceptable salt or solvate thereof for the preparation of a medicament for the prophylaxis and/or treatment of schizophrenia, depression, dementia, Parkinson's disease, Alzheimer's disease, Lewy bodies dementia, Huntington's disease, Tourette's syndrome, anxiety, a learning or memory impairment, a neurodegenerative disease, a cognitive impairment, nicotine dependence or pain.
15. Use of a compound of formula I according to any one of Claims 1 to 4 and/or a physiologically acceptable salt thereof for the preparation of a medicament for combating a neurodegenerative disease, a cerebrovascular disease, epilepsy, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's disease, cerebral ischaemia, infarction or a psychosis.
16. Use of a compound of formula I according to any one of Claims 1 to 4 and/or a physiologically acceptable salt thereof for combating a neurodegenerative disease, a cerebrovascular disease, epilepsy, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's disease, cerebral ischaemia, infarction or a psychosis.
17. Process for the preparation of a pharmaceutical composition, characterised in that a compound of formula I according to any one of Claims 1 to 4 and/or one of its physiologically acceptable salts and/or one of its solvates is converted into a suitable dosage form together with at least one solid, liquid or semi-liquid excipient or adjuvant.
18. Use of a compound of formula II

in which L1 is Cl, Br, I, OH, a reactively esterified OH group, selected from an alkylsulphonyloxy group having 1-6 carbon atoms or an arylsulfonyloxy group having 6-10 carbon atoms, or a diazonium group, and R1, D, E, R12, p and X1 are as defined in Claim 1, for the manufacture of a compound of formula la according to Claim 1.
19. Use of a compound of formula III

in which L2 is H or a metal ion, and q, y, X2 and Z are as defined in Claim 1, for the manufacture of a compound of formula la according to Claim 1.
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