CA2501396A1 - Lens care composition and method - Google Patents

Lens care composition and method Download PDF

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Publication number
CA2501396A1
CA2501396A1 CA002501396A CA2501396A CA2501396A1 CA 2501396 A1 CA2501396 A1 CA 2501396A1 CA 002501396 A CA002501396 A CA 002501396A CA 2501396 A CA2501396 A CA 2501396A CA 2501396 A1 CA2501396 A1 CA 2501396A1
Authority
CA
Canada
Prior art keywords
contact lens
solution
disinfecting solution
lens disinfecting
ppm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002501396A
Other languages
French (fr)
Other versions
CA2501396C (en
Inventor
Fu-Pao Tsao
Karen Frances Lindley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2501396A1 publication Critical patent/CA2501396A1/en
Application granted granted Critical
Publication of CA2501396C publication Critical patent/CA2501396C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/141—Biguanides, e.g. chlorhexidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/141—Biguanides, e.g. chlorhexidine
    • A61L12/142—Polymeric biguanides
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/0005—Other compounding ingredients characterised by their effect
    • C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/72—Ethers of polyoxyalkylene glycols

Abstract

An buffered aqueous contact lens disinfecting solution having much lower concentration of disinfecting agents, and less irritating to the eye. The solutions have a tonicity of 200 to 450 mOsm/kg, a pH of between 6 and 8, and a concentration of chloride ions below 1500 ppm. Despite having less than 1 ppm of antimicrobial, the solutions are effective against C. albicans within 15 minutes of contact.

Claims (30)

1. An aqueous contact lens disinfecting solution comprising a buffer and less than 1 ppm of a polymeric antimicrobial agent;
wherein said solution has a tonicity of 200 to 450 mOsm/kg, a pH of between 6 and 8, and a concentration of chloride ions below 1500 ppm.
2. An aqueous contact lens disinfecting solution as claimed in Claim 1, wherein the total concentration of chloride ions and phosphate ions is below 1500 ppm.
3. An aqueous contact lens disinfecting solution as claimed in Claim 1, wherein the total concentration of chloride ions and phosphate ions is below 1500 ppm.
4. An aqueous contact lens disinfecting solution as claimed in Claim 3, wherein the concentration of said PHMB is less than or equal to 0.5 ppm.
5. An aqueous contact lens disinfecting solution as claimed in Claim 4, wherein said solution will result in at least a 1 log reduction in C. albicans within 15 minutes of contact.
6. An aqueous contact lens disinfecting solution as claimed in Claim 3, wherein the concentration of said PHMB is less than or equal to 0.25 ppm.
7. An aqueous contact lens disinfecting solution as claimed in Claim 6, wherein said solution will result in at least a 1.5 log reduction in C. albicans within 15 minutes of contact.
8. An aqueous contact lens disinfecting solution as claimed in Claim 1, further comprising a tonicity agent selected from the group consisting of non-halide containing electrolytes, non-electrolytic compounds, and mixtures thereof; wherein the majority of the tonicity of the solution is provided by said tonicity agent.
9. An aqueous contact lens disinfecting solution as claimed in Claim 8, wherein said tonicity agent is sorbitol.
10. An aqueous contact lens disinfecting solution as claimed in Claim 9, the sorbitol is present in an amount of at least 2%, by weight, of said solution.
11. An aqueous contact lens disinfecting solution as claimed in Claim 1, wherein the buffer is a phosphate buffer at a concentration less than 0.1 %, and the total concentration of chloride ions and phosphate ions below 1000 ppm.
12. An aqueous contact lens disinfecting solution as claimed in Claim 11, wherein said phosphate buffer concentration is less than 0.06%.
13. An aqueous contact lens disinfecting solution as claimed in Claim 12, wherein said phosphate buffer concentration is from 0.005% to 0.015%.
14. An aqueous contact lens disinfecting solution as claimed in Claim 1, further comprising at least one surface-active agent.
15. An aqueous contact lens disinfecting solution as claimed in Claim 14, wherein said solution contains both tyloxapol and a poloxamer.
16. An aqueous contact lens disinfecting solution as claimed in Claim 1, further comprising dexpanthenol.
17. An aqueous contact lens disinfecting solution as claimed in Claim 1, further comprising a chelating agent.
18. An aqueous contact lens disinfecting solution as claimed in Claim 17, wherein said chelating agent is EDTA.
19. An aqueous contact lens disinfecting solution as claimed in Claim 1, further comprising a viscosity enhancing agent.
20. An aqueous contact lens disinfecting solution as claimed in Claim 19, wherein said viscosity enhancing agent is PVP.
21. An aqueous contact lens disinfecting solution comprising:
(a) less than 1 ppm PHMB;
(b) 0.005% to 1 % dexpanthenol;
(c) 0.005% to 1 % surface active agent;
(d) less than 0.06% phosphate buffer;
(e) less than 0.2% chelating agent;
(f) 0.01 % to 1 % viscosity enhancing agent; and (g) at least 1 % of a tonicity agent selected from the group consisting of glycerol, urea, propylene glycol, sodium bicarbonate, sugars, alcohols, polyols, and mixtures thereof;
wherein said solution has a tonicity of 200 to 450 mOsm/kg, a pH of between 6 and 8, and a concentration of chloride ions below 1000 ppm.
22. An aqueous contact lens disinfecting solution as claimed in Claim 21, wherein said surface active agent selected from the group consisting of tyloxapol, polaxamers, and mixtures thereof; said chelating agent is EDTA; said viscosity enhancing agent is PVP; and said tonicity agent is sorbitol.
23. An aqueous contact lens disinfecting solution as claimed in Claim 21, comprising:
(a) less than 0.5 ppm PHMB;
(b) 0.01 % to 0.1 % dexpanthenol;
(c) 0.001 % to 0.5% surface active agent;
(d) 0.001 % to 0.05% phosphate buffer;
(e) 0.1 % to 0.3% viscosity enhancing agent; and (f) at least 4% of a tonicity agent selected from the group consisting of glycerol, urea, propylene glycol, sodium bicarbonate, sugars, alcohols, polyols, and mixtures thereof;
wherein said solution has a tonicity of 200 to 450 mOsm/kg, a pH of between 6 and 8, and a concentration of chloride ions below 500 ppm.
24. An aqueous contact lens disinfecting solution as claimed in Claim 23, wherein said surface active agent is selected from the group consisting of tyloxapol, polaxamers, and mixtures thereof; said chelating agent is EDTA; said viscosity enhancing agent is PVP; and said tonicity agent is sorbitol.
25. A method for cleaning and disinfecting a contact lens comprising contacting said contact lens with an aqueous solution comprising a buffer and less than 1 ppm of a polymeric antimicrobial agent; wherein said solution has a tonicity of from 200 to 450 mOsm/kg, a pH
of between 6 and 8, and a concentration of chloride ions below 1500 ppm.
26. A method as claimed in Claim 25, wherein said polymeric antimicrobial agent is PHMB.
27. A method as claimed in Claim 26, wherein the concentration of said PHMB is less than or equal to 0.5 ppm.
28. A method as claimed in Claim 27, wherein said method results in at least a 1 log reduction in C. albicans upon the lens within 15 minutes of contact.
29. A method as claimed in Claim 26, wherein the concentration of said PHMB is less than or equal to 0.25 ppm.
30. A method as claimed in Claim 29, wherein said method results in at least a 1.5 log reduction in C. albicans upon the lens within 15 minutes of contact.
CA2501396A 2002-12-13 2003-12-12 Lens care composition and method Expired - Fee Related CA2501396C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43317302P 2002-12-13 2002-12-13
US60/433173 2002-12-13
PCT/EP2003/014138 WO2004054629A1 (en) 2002-12-13 2003-12-12 Lens care composition and method

Publications (2)

Publication Number Publication Date
CA2501396A1 true CA2501396A1 (en) 2004-07-01
CA2501396C CA2501396C (en) 2012-08-07

Family

ID=32595129

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2501396A Expired - Fee Related CA2501396C (en) 2002-12-13 2003-12-12 Lens care composition and method

Country Status (8)

Country Link
US (1) US7550418B2 (en)
EP (1) EP1572253B1 (en)
JP (1) JP2006510414A (en)
AT (1) ATE375174T1 (en)
AU (1) AU2003298179A1 (en)
CA (1) CA2501396C (en)
DE (1) DE60316836T2 (en)
WO (1) WO2004054629A1 (en)

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US20070048345A1 (en) * 2005-08-31 2007-03-01 Kimberly-Clark Worldwide, Inc. Antimicrobial composition
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TW201000155A (en) * 2008-05-06 2010-01-01 Alcon Inc High refractive index ophthalmic device materials
CN102177016B (en) * 2008-08-28 2015-11-25 泰科保健集团有限合伙公司 Antimicrobial fibre and correlated product and method
JP6654340B2 (en) * 2013-04-12 2020-02-26 ロート製薬株式会社 Contact lens composition and contact lens package using the same
US9982220B2 (en) * 2015-05-19 2018-05-29 Ecolab Usa Inc. Efficient surfactant system on plastic and all types of ware
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Also Published As

Publication number Publication date
CA2501396C (en) 2012-08-07
DE60316836D1 (en) 2007-11-22
DE60316836T2 (en) 2008-07-17
EP1572253B1 (en) 2007-10-10
WO2004054629A1 (en) 2004-07-01
ATE375174T1 (en) 2007-10-15
US7550418B2 (en) 2009-06-23
JP2006510414A (en) 2006-03-30
US20040142829A1 (en) 2004-07-22
AU2003298179A1 (en) 2004-07-09
EP1572253A1 (en) 2005-09-14

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Effective date: 20131212