CA2503563A1 - Medical appliance deployment apparatus and method of use - Google Patents

Medical appliance deployment apparatus and method of use Download PDF

Info

Publication number
CA2503563A1
CA2503563A1 CA002503563A CA2503563A CA2503563A1 CA 2503563 A1 CA2503563 A1 CA 2503563A1 CA 002503563 A CA002503563 A CA 002503563A CA 2503563 A CA2503563 A CA 2503563A CA 2503563 A1 CA2503563 A1 CA 2503563A1
Authority
CA
Canada
Prior art keywords
tubular member
stent
deployment
inner tubular
outer tubular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002503563A
Other languages
French (fr)
Inventor
Liann M. Johnson
Paul S. Sherburne
Alicia F. Heck
Ricci D. Smelser
Eric K. Mangiardi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alveolus Inc
Original Assignee
Alveolus Inc
Liann M. Johnson
Paul S. Sherburne
Alicia F. Heck
Ricci D. Smelser
Eric K. Mangiardi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alveolus Inc, Liann M. Johnson, Paul S. Sherburne, Alicia F. Heck, Ricci D. Smelser, Eric K. Mangiardi filed Critical Alveolus Inc
Publication of CA2503563A1 publication Critical patent/CA2503563A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95Instruments specially adapted for placement or removal of stents or stent-grafts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/962Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
    • A61F2/966Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/9517Instruments specially adapted for placement or removal of stents or stent-grafts handle assemblies therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/008Alarm means

Abstract

INTERNATIONAL SEARCH REPORT International application No. PCT/US03/33967 Box III TEXT OF THE (Continuation of Item 5 of the first sheet) NEW The present invention, in an exemplary embodiment, provides a stent deployment apparatus comprising excellent features. A stent deployment apparatus in the present invention can facilitate the precise delivery of stents in a safe and repeatable fashion. In particular, a preferred deployme nt apparatus allows the physician to concentrate on correct placement by providing a physical safety mechanism that limits deployment to the critical deployment point. Moreover, to exceed this threshold, an audible and/or tactile indicator informs the physician that she can no longer retract the stent beyond this point. The stent deployment apparatus guide,%ire may also be extended rather than retracting the outer catheter to deliver the stent. Moreover, the distal tip is designed to facilitates the removal of the deployment apparatus even if a defective stent is only partially radially expanded. In alternative embodiments, the stent deployment apparatus allows for the insertion of an optical scope to facilitate stent delivery.

Description

2 PCT/US2003/033967 MEDICAL APPLIANCE DELIVERY APPARATUS AND METHOD OF USE
FIELD OF THE INVENTION
The present invention relates generally to medical devices directed to the prevention of nonvascular vessel or passageway occlusion, and more particularly to stent deployment apparatuses and methods for utilizing these devices in the treatment of both benign and malignant conditions.
BACKGROUND OF THE INVENTION
Stents are devices that are inserted into a vessel or passage to keep the lumen open and prevent closure due to a stricture, external compression, or internal obstruction. In particular, scents are commonly used to keep blood vessels open in the coronary arteries and they are frequently inserted into the ureters to maintain drainage from the kidneys, the bile duct for pancreatic cancer or cholangiocarcinoma or the esophagus for strictures or cancer.
Nonvascular stenting involves a range of anatomical lumens and various therapeutic approaches, however, accuracy of installation is universally important.
In order to serve its desired function, the stent must be delivered precisely and oriented correctly. In order to facilitate the delivery of stents, medical device companies began to design deployment apparatuses that allow physicians to deploy scents more precisely. Unfortunately, guidance of the stent has substantially remained a function of physician skill resulting from substantial practice. This fact has become particularly evident with the advent of radially expanding scents. If after full deployment of the stent, the physician discovers the stent has been implanted incorrectly, there is no conventional way of correcting the error short of removing the stent. In particular, as a rule of thumb, once the exterior catheter, of conventional delivery devices; has been retracted beyond 60~, it generally cannot be realigned with respect to the stent. As a result, physicians must be sure of their stent placement prior to deploying the scent beyond the 60~ point. We will refer to this 60~ point throughout the application as the critical deployment point.
Conventional stent delivery devices, however, do not have any safety mechanism' to prevent excessive deployment of a misaligned stent. In fact, conventional delivery devices require the physician to estimate extent of deployment, which results in either overly conservative or excessive deployment -- both of which leads to stent misplacement.
An additional limitation of conventional stent delivery devices is the distal tip of conventional scent delivery devices are not adequately designed to (1 ) facilitate the clearance of obstructed lumen, or (2) facilitate the removal of the delivery device once the stent is radially expanded. In particular, most distal tips are not configured to comfortably guide the delivery device through a diseased or occluded lumen so that the scent can be delivered in the most beneficial location. Moreover, once the stent is radially expanded conventional designs rely exclusively on dimensional mismatching to ensure proper removal of the delivery device. In the event the stent does not adequately expand to preset dimensions, a conventional delivery device would be stuck in the patient until some invasive procedure is performed to remove it and the defective stent.
3 Therefore, there remains an existing need for a stent deployment apparatuses that has a safety mechanism to prevent excessive deployment of a misaligned stent. Preferably it would be desirable if the safety mechanism had a physical and/or audible indication means to inform the physician when she has reached maximum reversible deployment. As an additional safety feature, there is an existing need for a distal tip designed to allow for the removal of the deployment apparatus even if the stent does not radially expand to~ its preset expansion diameter. An existing need also exists for a scent deployment apparatus that has a distal tip adequately configured to navigate through diseased and/or occluded lumens so that the scent can be delivered to this target area.
There also remains an existing need for a scent deployment apparatus that increases physician control during stent deployment.
Moreover, there exists a need for a scent deployment apparatus that allows for the insertion of an optical scope to facilitate scent delivery.
SUMMARY OF EXEMPLARY EMBODIMENTS
It is a principal objective of an exemplary scent deployment apparatus in accordance with the present invention to provide a device that can facilitate the precise delivery of scents in a safe and repeatable fashion. In the furtherance of this and other objectives, a preferred deployment apparatus allows the physician to concentrate on correct placement without having to estimate extent of deployment. In particular, in a preferred embodiment, the present deployment apparatus has a physical safety mechanism that limits deployment to the critical deployment point (i.e., ~60%). The critical deployment point may range form 5% to 95% but is preferably about
4 600. At this point, if the physician is satisfied with placement, she can engage the safety means to what we refer to as the Proceed Orientation (PO) and fully deploy the stent. It is preferred that when the safety mechanism is engaged to the PO, a physical twist and a possible audible indicator sounds to inform the physician that if she deploys the stent any further, she can no longer retract the scent beyond this point. Though the present stent and delivery system eliminates the need for repositioning, such safety features are still preferable. In a preferred embodiment, the slight audible indication is the sound of a tab or stop snapping to allow free deployment of the stent.
An additional objective of a preferred embodiment of the present invention is to provide a stent deployment apparatus where the handle portion is held and the outer tubular member of the device is retracted.
Yet another objective in accordance with the present invention is to provide a deployment apparatus having a distal tip designed to facilitate the clearance of obstructed lumen. In the furtherance of this and other objectives, the exemplary distal tips are configured to comfortably guide the deployment apparatus through a diseased or occluded lumen so that the stent can be delivered in the most beneficial location.
Still another objective of a preferred deployment apparatus in accordance with the present invention is to provide a distal tip that facilitates the removal of the deployment apparatus once the scent is radially expanded. In the furtherance of this and other objectives, the distal tip is designed to clear the scent during removal, in the event the scent does not adequately expand to preset dimensions. In a preferred embodiment, removal is facilitated by providing a distal tip that has a substantially bidirectional conic shape. This allows for the removal of the present deployment apparatus, while conventional deployment apparatuses would be stuck in the patient until some invasive procedure was performed to remove it and the defective
5 stent. This results from the fact that conventional deployment apparatus designs rely exclusively on dimensional mismatching between the distal tip and the radially expanded scent to ensure proper removal of the deployment apparatus. As a function of the design of the present invention, the compressed scent is adequately retained in place and does not prematurely creep up the proximally facing conic end of the distal tip and prematurely deploy.
An additional objective in accordance with an exemplary embodiment of the present invention is to provide a scent deployment apparatus that allows for the insertion of an optical scope to facilitate stent delivery. In the furtherance of this and other objectives, the device is capable of letting a flexible optical scope of about 5-6 mm diameter be coupled along the exterior of the outer tubular member thereof. Alternatively, it is envisioned that an ultra thin optical scope may pass along side the guidewire through the internal diameter of the internal tubular member of the device.
In addition to the above objectives, an exemplary stem deployment apparatus preferably has one or more of the following characteristics: (1) applicable for various interventional applications such as addressing stenosis; (2) biocompatible; (3) compliant with radially expanding stents; (4) capable of distal or proximal stent release; (5) smooth and clean outer surface; (6) length of the device variable according to the insertion procedure to be employed; (7) outer dimension as small as possible (depends on the diameter of crimped scent); (8) dimensions of the device must offer enough space
6 for the crimped scent; (9) radiopaque markers, preferably on the inner tubular member, to indicate proximal and distal ends of the stent; (10) sufficient flexibility to adapt to luminal curvatures without loss of ability to push or pull; (1 1 ) low friction between the inner tubular member and outer tubular member; (12) sufficient resistance to kinking; (13) good deployment, ability to reposition partially deployed scent; ( 14) added with a scale to observe the scent position during the insertion procedure; (15) insertion procedure should require low force;
or (16) sufficiently economical to manufacture so as to make the deployment apparatus disposable.
Further objectives, features and advantages of the invention will be apparent from the following detailed description taken in conjunction with the accompanying drawings.
BRIEF DESCRIPTION OF THE FIGURES
1S FIG. 1 is a perspective view of a device for delivering and deploying a radially self-expanding stent in accordance with the present invention;
FIG. 2 is a side view of the device for delivering and deploying a radially self-expanding scent in accordance with the present invention.
FIG. 3A depicts enlarged views of portions of the deployment safety mechanism along lines 3A-3A of the device of FIG. 2 FIG. 3B shows a cross section view of the deployment safety mechanism along lines 3B-3B of FIG. 3A;
FIG. 3C is a perspective view of a portion of the complementary portion of the deployment safety mechanism region of the handle as shown along lines 3C-3C of FIG. 3A;
7 FIG. 3D is a perspective view of the stop of the deployment safety mechanism as shown along lines 3C-3C of the device of FIG.
3A.
FIG. 4A is a side perspective view of the distal region of the device of FIG. 2, along lines 4A-4A;
FIG. 4B depict an enlarged sectional view of the distal region of the device of FIG. 2, along lines 4B-4B.
DETAILED DESCRIPTION OF AN EMBODIMENT
~ A general problem in the diagnosis and therapy of both vascular and nonvascular anomalies is the fact that the instruments must be inserted into or pass the area of maximum diameter of about mm. As a result, the inserted instruments take away a very large portion of the free lumen and may increase the danger of injury to the 15 patient.
Therefore, it is the primary objective of the present invention to provide an instrument, which can be inserted gently, ensures a good utilization of the available space and makes it possible to carry out active therapeutic measures, wherein the instrument is to be particularly suitable for the introduction and placement of stents.
A preferred embodiment of the present deployment apparatus comprises inner and outer tubular members interactively coupled with each other in a manner that one can move rotationally and proximally or distally with respect to the other. The tubular members are preferably nonpyrogenic. In order to deliver the scent, the deployment apparatus comprises a distal tip and a stent retaining hub, between which the scent is placed. The distal tip and the stent-retaining hub are both functionally coupled with the inner tubular member. The inner tubular member terminates with a luer or in a
8 preferred embodiment, a proximal handle similar to the outer handle hub. The luer is preferably a female threaded luer, but. alternative termini are within the skill of the stent deployment device engineer. In fact, a suitable alternative would be a handle having similar internal diameter characteristics as the luer while providing greater surface area for manipulating the deployment apparatus. As stated above, a preferred alternative would be a proximal handle that is similar in geometrical shape but preferably smaller than the outer handle hub, to facilitate movement, however the proximal handle may be of any size functionally acceptable by the user. The deployment apparatus is preferably sterilized by a validated sterilization cycle EtO. Moreover, the device is capable of resterilization (validated cycle) with no degradation of performance. However, it is preferable to provide a disposable device.
The deployment apparatus is preferably about 100 cm ~ 2 cm total. The inner diameter of the inner tubular member is approximately about 1 mm and the outer diameter of the outer tubular member is preferably about 5 to 6 mm in diameter. For purposes of this discussion, the usable length of the inner tubular member shall be from the inner tubular member distal hub/handle end to the distal tip. The usable length of the outer tubular member shall be from the distal hub/handle end of the outer tubular member to the distal tip. The overall length of the device shall be from the distal hub/handle end of the outer tubular member to the distal tip of the inner tubular member when assembled and not deployed. There will also be preferably three radiopaque (platinum iridium) markers for marking the scent, the stent deployment distance, and depth. The outer tubular member is preferably manufactured of stiffer synthetic
9 material. In a preferred embodiment, the length of the outer tubular member is preferably shorter than that of the inner tubular member.
However, these dimensions may differ as a function of the scent diameter and/or if an optical scope is employed to facilitate scent delivery. The outer tubular member may be configured to allow for the coupling of an optical scent along the outer diameter thereof.
Alternatively, the inner diameter of the inner tubular member may be enlarged sufficiently to accommodate the optical scope and additionally the increased crimped stent diameter. However, it is expected, though not required, that the smallest diameter that allows for example a bronchoscope to pass will be employed in this alternative embodiment. It should be understood that through hindsight, after exposure to the present specification, one of ordinary skill would be able to adapt the current device to receive an ultra thin optical scope to the internal diameter of the device without undo experimentation and without departing from the spirit of the present objectives.
An exemplary deployment apparatus in accordance with the present invention is durable while affording adequate flexibility to navigate through anatomical lumens without kinking. To this end, it is preferable that the deployment apparatus is formed of biocompatible synthetics and in a preferred embodiment reinforced with metal structure. This should allow for deployment within an accuracy of about ~ 3 mm. Moreover, the scent is preferably released with a force lower than 30 tJewtons at 37°C though the force and deployment temperatures may be modified to suit the needs of specific anatomical conditions.
The inner tubular member is composed of a thin elastic synthetic material, such as polyurethane or Teflon. At its proximal end, the inner tubular member has a standard adaptor or connector. At its distal end, the inner tubular member is equipped with a tip specific for various anatomical lumens.
The inner tubular member and the outer tubular member can be 5 displaced relative to each other in longitudinal direction as well as in a radial direction. The deployment apparatus in accordance with the present invention can be used most advantageously for the placement of stents. Such stents are available in various embodiments of metal and/or synthetic material. They usually are
10 composed of a fabric of metal wires, which expand by themselves as a result of their natural tension. Scents of a so-called shape memory alloy are also known..These scents have a small radial diameter at a low temperature, while ~ they expand radially when exceeding an upper threshold temperature, so that they can keep a stenosis open in this manner. It is particularly advantageous to use stents of an alloy of nickel and titanium, the so-called nitinol.
An exemplary deployment apparatus according to the present invention can be used for the placement of various stents, whether they are self-expanding scents or stents, which require an activation.
For this purpose, the scent is placed in the free space between the outer tubular member and the inner tubular member. Positioning of the scent in the deployment apparatus can be carried out in the area between the tip and the stent retaining hub at the distal end of the inner tubular member. Alternatively, in its insertion position,, fasteners or other suitable retaining elements may hold the scent.
In relevant embodiments, when the stent is inserted and after the stenosis has been passed, the outer tubular member is retracted, so that the stem is released. Alternatively, the distal end of the outer tubular member may be placed about the stenosis so that the inner
11 tubular member may be extended so that the scent is placed in direct contact with the desired location prior to expansion. A self-expanding stent then by itself assumes the expanded position. This eliminates the need for post expansion positioning techniques. With an alternative embodiment of the device, the device has fasteners that retain contact with a portion of the stent in the event that the stent needs to be retracted or repositioned. A stent suitable for such procedures would be one in accordance with the disclosure in co-pending U.S. Patent Application Serial No. 10/ 190,770, which is incorporated herein in its entirety by this reference.
The following reference numbers and corresponding stent placement and deployment device components are used when describing the device in relation to the figures:
10 Scent Delivery & Deployment Device
12 Guidewire 14 Proximal Handle/Female Threaded Luer 16 Hypotube 18 Safety Mechanism Stop 20 22 Female Locking Member on the Stop 24 Tab of the Stop Inner Tubular Member 32 Inner Diameter of Inner Tube Handle 25 42 Cavity in Proximal Portion of Handle 44 Base of Handle Cavity 46 Male Locking Member 48 Inner Handle Hub 49 Outer Handle Hub 30 50 Outer Tubular Member 52 Outer Diameter of Outer Tubular Member 54 Distal Region of Outer Tubular Member 56 Inner Diameter of Outer Tubular Member 60 Distal Tip 35 62 First End of the Tip 64 Medial Region of the Tip 66 Second End of the Tip 68 Axial Passage 70 Retaining Hub 72 Distal Region of Retaining Hub 74 Proximal Hub of Retaining Hub 76 Pusher 80 Proximal Marker 82 Medial Marker 84 Distal Marker The figures show an exemplary placement and deployment device 10 in accordance with the present invention. Referring in particular to FIGS. 1-2, the present invention provides a stent deployment apparatus 10 that includes an outer tubular member 50 and an inner tubular member 30, wherein the outer tubular member 50 and the inner tubular member 30 can be displaced relative to each other. At the proximal end of an exemplary device 10 is a threaded female luer 14, coupled with a portion of the inner tubular member 30 and preferably .a portion of a hypotube 16. As stated earlier, a suitable alternative terminus may be employed as long as it provides the minimum benefits provided by a luer. The hypotube 16 is disposed about the inner tube 30 and extends from a location adjacent to the luer 14 through a portion of the handle 40 of the deployment apparatus 10. In an alternative embodiment, the hypotube 16 terminates within the luer 14. A safety mechanism 18 is provided that is formed in part by the complementary fitting of a portion of the handle 40 and a stop 20 coupled with the hypotube 16 between the luer 14 and the handle.40. The stop 20 is preferably molded onto the hypotube 16, the molding process resulting in a tab 24 formed on the stop 20 that is subsequently broken when the physician desires to place the deployment apparatus 10 in the proceed orientation. In an exemplary embodiment, when the tab 24 is broken and the deployment apparatus 10 is placed in the proceed orientation; the
13 stop 20 may potentially rotate freely about the hypotube 16. It should be kept in mind that the stop 20 may take a variety of shapes, including but not limited to, rectangular, round, conical etc. In a preferred embodiment, the stop 20 is conical with a tapered effect to facilitate entrance and removal from the base handle cavity 44.
As illustrated in FIGS. 3A-3D, a preferred stop 20 includes female locking members 22 comprising channels formed along the exterior thereof that are complementary to the male locking members 46 formed on the interior cavity 42 along the proximal region of the handle 40. The cavity 42 of the handle 40 is designed to receive the stop 20 and prevent further deployment. As a result, the stop 20 is molded at a distance along the hypotube 16 such that the distance betv~een the distal end of the stop and the base 44 of the complementary cavity 42 of the handle 40 roughly corresponds to the critical deployment point. It should be noted that the female locking members 22 and male locking members 46 of the safety mechanism 18 might be reversed so that the female locking members 22 and male locking members 46 are on the handle 40 and the stop 20, respectively. Additionally, alternative safety mechanisms may be employed to ensure accurate deployment beyond the critical deployment point.
' The handle 40 is preferably molded to a portion of the outer tubular member 50, v~hich extends from the handle 40 to the distal tip 60 of the device 10. The outer tubular member 50 is disposed about the inner tubular member 30. In an exemplary embodiment, the outer tubular member 50 is clear so that the inner tubular member 50 is visible there through. Moreover, markers 80-84 preferably formed on portions of the inner tubular member 30 are also visible through the outer tubular member 50.
14 Referring now to FIGS. 4A-4B, in the distal region 54 of the device 10, there is a stent placement hub 70, which holds the stent (not shown) during the placement procedure. In a preferred embodiment, the stent placement hub 70 comprises two double conical shaped elements, one disposed at each end of the scent and coupled with the inner tubular member 30. In an exemplary form, the distal most double conical shaped element is the distal tip of the device 60. In alternative embodiments, the scent placement hub may also comprise proximal 72 and distal 74 stops between which the stent rests in its crimped state. Moreover, the proximal end of the stent may also be restrained by conventional coupling methods (not shown) to facilitate retrieval if necessary. By way of example, which is in no way to be construed as limiting, a stent having suture disposed about its proximal end may be retained by the stent retaining hub 70 that has releasable finger-like members engaging the suture.
The device is configured such that an optional guidewire 12 may be passed through the internal diameter 32 of the device through the luer 14 at the proximal end, the distal tip 60 at the distal end and the inner tubular member 30 there between. In an alternative embodiment, the internal diameter 32 of the device 10 is sufficient to receive an optical scope (not shown) there through.
Referring to the functional aspects of the device 10, there is shown in FIG. 1 a deployment apparatus 10 that includes an elongate and flexible outer tubular member 50 constructed of at least one biocompatible thermoplastic elastomer, e.g. such as polyurethane and nylon, typically with an outside diameter 52 in the range of about between 6-9 mm. A central lumen 56 runs the length of the outer tubular member 50. A distal region 54 of the outer tubular member 50 surrounds the stent to be placed (not shown), and maintains the stent in a crimped delivery configuration, against an elastic restoring force of the scent. The scent, when in a normal unrestrained configuration, generally has a diameter (for example, 10-20 mm) substantially larger than the interior diameter 32 of the inner tubular member 30. Typically 5 the expanded stent is larger in diameter than the body lumen in which the stent is fixed, and the restoring force fends to maintain the stent against the tissue wall.
Outer tubular member 50 is mounted at its proximal end to a handle 40. Outer tubular member 50 can be pushed and pulled 10 relative to inner tubular member 30 by hand manipulation of the handle 40 at the proximal end of the outer tubular member 30 and holding the proximal end of the handle 40.
A guidewire 12 is preferably disposed within the interior lumen 32 of an elongate and flexible inner tubular member 30, which can be
15 constructed of materials similar to those employed to form the outer tubular member 50. However, it is preferable that inner tubular member 30 is formed from a more durable material. A distal tip 60 is coupled with inner tubular member 30 about the distal end thereof.
Also attached to the inner tubular member 30 are a proximal marker 80, at least one medial marker 82 and a distal marker 84. The markers are constructed of a radiopaque material, e.g. platinum iridium, and surround the inner tubular member 30. Markers 80, 82 and 84 are axially spaced apart to mark the length of the stent and to mark the critical deployment distance for that scent length. The markers identify a stent-retaining hub 70 of the inner tubular member 30, more particularly the distal region of the inner tubular member 30 is surrounded by stent 12. The markers may also be of varying sizes and shapes to distinguish distance between distal and proximal regions.
Markers 80 and 84 may have outer diameters slightly smaller than the
16 interior diameter of outer tubular member 50. The outer tubular member 50 thus functions as a carrier for the scent, with inner tubular member 30 providing a retaining means for radially compressing the stent and maintaining the scent along the scent retaining hub 50, so long as the outer tubular member 50 surrounds the stent.
In an alternative embodiment, items 72 and 74 are marker bands (not retaining hubs) formed on the outer tubular member 50.
These marker bands visually mark the ends of the stent and thus will be over the step area of the tip and the pusher 76. All the marker bands -including 80, 82 and 84 are preferably either Platinum Iridium or Stainless Steel. Moreover, the marker bands of 80, 82, and 84 will be depth marks and will be spaced in preferably 1 cm intervals. These depth marks are preferably formed on the inner tubular member 30 and are a visual aid for the physician to assist with determining the depth at which the scent has been advanced.
Inner tubular member 30, along its entire length, has an interior lumen 56 open to both the proximal and distal ends of the inner tubular member 30. An axial passage 68 through distal tip 60 continues lumen 32 to allow the guidewire 12 to pass from the luer 14 through the distal tip 60.
Handle 40 and outer tubular member 50 are movable relative to inner tubular member 30. More particularly, the handle 40 is moved proximally relative to the scent-retaining hub 70, facilitating the movement of outer tubular member 50 relative to inner tubular member 30 so as to provide a means for controllably withdrawing the outer tubular member 50, relative to the inner tubular member 30, resulting in the release of the stent for radial self-expansion.
When the device 10 is used to position the stent, the initial step is to position guidewire 12 within the anatomy of a patient. This can be
17 accomplished with a guide cannula (not illustrated), leaving guidewire 12 in place, with the exchange portion of the guidewire extended proximally beyond the point of entry into the anatomy of the patient. Deployment apparatus 10 is then advanced over the guidewire 12 at the exchange portion, with the guidewire 12 being received into passage 68 of distal tip 60. As device 10 is inserted into the body, the proximal portion of guidewire 12 travels proximally (relative to the device) to the proximal end of guidewire lumen 32.
Once device 10 is positioned, the physician maintains guidewire 12 and inner tubular member 30 substantially fixed with one hand, while moving handle 40 in the proximal direction with the other hand, thus to move outer tubular member 50 proximally relative to inner tubular member 30. As the outer tubular member 50 is retracted, the stent remains substantially fixed relative to inner tubular member 30, and thus radially self-expands. As the handle 40 and correspondingly the outer tubular member 50 is retracted, the handle 40 encounters the safety mechanism 18 for the critical deployment point. The inner tubular member 30, via the handle 40, may have to be rotated to align and insert the stop 20 into the handle 40. When fully inserted, further deployment cannot occur without twisting and snapping the stop the tab 24 portion of the stop 20. Continued retraction of the outer tubular member 50 results in complete deployment of the scent.
After deployment, the scent ideally radially self-expands to a diameter greater than the diameter of outer tubular member 50.
Accordingly, device 10 can be withdrawn proximally through the scent. However, in the event that the scent does not radially expand fully, distal tip 60 is configured to facilitate removal of deployment apparatus 10 through the lumen of the stent.
18 Guidewire 12 can be withdrawn as well. The guidewire 12 emerges from the proximal end of the luer 14. However, should the medical procedure involve further treatment, e.g., placement of a further scent, the deployment apparatus 10 can be removed without removing the guidewire 12. Device 10 is removed by progressively pulling the device away from the guidewire 12 (which removes the guidewire from within the inner tubular member 30), all while maintaining guidewire 12 in place.
Returning to distal tip 60, as illustrated in FIGS 4A-4B, distal tip 60 can have a variety of confirmations, but by way of non-limiting example, distal tip 60 comprises first 62 and second 66 ends having a smaller diameter than the medial region 64 thereof. In a preferred embodiment, each end is conical in shape so as to allow the tip 60 to wedge through an incompletely expanded scent when pulled proximally with respect to the stent. Moreover, the dual conical end design facilitates removal but sufficiently prevents the crimped stem from releasing from the stent retaining hub 70 and prematurely expanding. Distal tip 60 may alternatively have a flared medial region 64 so as to facilitate retrieval and retraction of a misaligned stent, 12.
With respect to additional safety features incorporated in the present device 10, in a preferred embodiment, the device 10 has a deployment safety mechanism 18 that comprises male 46 and female 22 locking members that are brought into functional engagement as the scent is being deployed. Once the scent has reached the critical deployment point, the distal end of the stop 20 is substantially flush with the base 44 of the handle cavity 42 and the female locking members 22 of the stop 20 are in operative communication with the corresponding male locking members 46 formed on the interior
19 surface of the cavity 42 of the handle. When the safety mechanism 18 is engaged as described above, the stent cannot be deployed further without physician intervention. In order to deploy the stent beyond this point, the physician has to rotate the stop 20 to cause the tab 24 to break. Once the tab 24 is broken, the device 10 is in the proceed orientation and deployment may proceed.
In a preferred embodiment, the physician will feel a tactile indication that the device 10 can be deployed further. Alternatively, the breaking of the tab may also, or as a substitute to tactile indication, results in an audible indication that further deployment is possible. Additionally, the physician is apprised of the fact that deployment beyond this point is irreversible except for interventional retrieval methods. As discussed earlier, the critical deployment point is preferably about 60~o deployment, beyond which retraction is not recommended. As a result, the safety mechanism 18 removes the need to estimate extent of deployment and provides a reliable means of accurately deploying stents. Alternative locking mechanisms may be provided as long as they retain the important characteristic of giving the physician a sensory indication of extent of scent deployment and removes the need to estimate extent of deployment. By way of non-limiting example only, the locking mechanism could comprise a breakable seal, tab/stop lock, diverted channel locking mechanism, etc.
Referring particularly to FIG. 5, an alternative safety mechanism 118 is presented that is a principally a diverted channel mechanism.
In practice, a detent 90 formed preferably on the hypotube has free proximal/distal travel to the critical deployment point at which time physician intervention is required to continue deployment. In a preferred embodiment, the Inner Tubular Member 30 is rotated until the travel of the decent is no longer obstructed. The channel in which the detest travels may be of a variety of geometrical shapes such as M, W, L, S Z, etc; the preferred geometry being substantially Z shaped, as shown in FIG. 5.
5 In an additional embodiment (not shown) of deployrrient safety mechanism 118, the device 10 has a deployment safety mechanism that comprises male and female locking members that are brought into functional engagement as the stent 12 is being deployed. Once the stent 12 has reached the critical deployment point, the male 10 locking member cannot be advanced further because of a detest formed on the inner diameter of the outer tubular member catches the cavity formed on the corresponding portion of the male locking member. As a result, in order to further advance the device 10 to fully deploy stent 12, the inner tubular member must be rotated so as to 15 break the detest. Once the detest is broken, the physician will feel a tactile indication that the device 10 can be deployed further.
Alternatively, the breaking of the detest may also, or as a substitute to tactile indication, results in an audible indication that further deployment is possible. Additionally, the physician is apprised
20 of the fact that deployment beyond this point is irreversible except for interventional retrieval methods. As discussed earlier, the critical deployment point is preferably about 60% deployment, beyond which retraction is not recommended. As a result, the safety locking system 60 removes the need to estimate extent of deployment and provides a reliable means of accurately deploying stents. Alternative locking mechanisms may be provided as long as they retain the important characteristic of giving the physician a sensory indication of extent of stent deployment.
21 The present invention may be embodied in other specific forms without departing from its spirit or essential characteristics. The described embodiments are to be considered in all respects only as illustrative, and not restrictive. The scope of the invention is, therefore, indicated by the appended claims, rather than by the foregoing description. All changes, which come within the meaning and range of equivalency of the claims, are to be embraced within their scope. ,

Claims (21)

What is claimed is:
1. A device for allowing a user to deploy a stent in an anatomical lumen of a patient, the device comprising:
a longitudinally extending inner tubular member having distal and proximal ends, the distal end comprising a tip;
a longitudinally extending outer tubular member having an outer and inner diameter, the outer tubular member being longitudinally and axially displaceable relative to the inner tubular member;
a handle, coupled with a portion of the outer tubular member, the handle having first and second ends and the second end defining a cavity having at least one stop compatible locking member formed therein;
a hypotube having a first end, a second end, an outer surface, an inner surface and a stop formed on the hypotube between the first and second ends, the outer surface of the stop comprising at least one locking member complementary to the handle cavity to form a safety mechanism;
whereby the extent of displaceability of the outer tubular member and inner tubular member relative to the other is limited by the safety mechanism to a predetermined threshold absent intervention by the user of the device such that the degree of stent deployment is limited absent the user intervention.
2. The device of claim 1, wherein the inner tubular member defines a lumen longitudinally extending substantially the distance from the distal end to the proximal end of the inner tubular member, which allows a guidewire to extend through the lumen thereof.
3. The device of claim 1, wherein the user intervention comprises displacing the outer tubular member axially relative to the inner tubular member.
4. The device of claim 3, wherein an audible indication follows the user intervention.
5. The device of claim 3, wherein a tactile indication follows the user intervention.
6. The device of claim 3, further comprising at least one tab formed on the stop when the stop is molded on the hypotube, which serves as the audible indication when broken during user intervention.
7. The device of claim 1, wherein the predetermined threshold is about between 10% and 90% deployment.
8. The device of claim 7, wherein the predetermined threshold is about 60% deployment.
9. The device of claim 3, wherein the outer tubular member when moved longitudinally relative to the inner tubular member in a proximal direction away from the selected location, releases the stent for radial self-expansion.
10. The device of claim 1, wherein a guidewire is coupled to a portion of the outer diameter of the outer tubular member.
11. The device of claim 1, wherein the inner tubular member is configured to receive an optical scope.
12. The device of claim 1, wherein the outer tubular member is clear.
13. the device of claim 1, wherein there is at least one marker coupled with a portion of the inner tubular member.
14. The device of claim 1, wherein the inner tubular member is of a material that is kink resistant.
15. The device of claim 12, wherein the outer tubular member is kink resistant.
16. The device of claim 1, wherein the distal tip has first, medial and second sections, the first and second sections having outer diameters that are less than that of the medial section.
17. The device of claim 1, wherein a portion of the inner tubular member about the proximal end further comprises a stent carrier adapted to carry a radially self-expanding stent in a radially contracted state.
18. The device of claim 17, further including a radially self-expanding stent carried by the stent carrier, extended along and surrounding at least part of the distal end region, and surrounded by a portion of the outer tubular member and thereby maintained in the radially contracted state.
19. A device for allowing a user to deploy a stent in an anatomical lumen of a patient, the device comprising:

a longitudinally extending outer tubular member having distal and proximal ends and a safety catch assembly disposed between the distal and proximal ends; and a longitudinally extending inner tubular member having distal and proximal ends, the inner tubular member being longitudinally and axially displaceable relative to the outer tubular member and wherein the distal end comprises a tip, the inner tubular member further comprises at least one detent along the longitudinal expanse thereof for operative interaction with the safety catch assembly of the longitudinally extending outer tubular member;
whereby the extent of displaceability of the outer tubular member and inner tubular member relative to the other is limited to a predetermined threshold absent intervention by the user of the device such that the degree of stent deployment is limited absent the user intervention.
20. A method of deploying a radially expandable stent comprising the steps of:
providing a stent deployment apparatus comprising a stent, a longitudinally extending outer tubular member having distal and proximal ends and a safety catch assembly disposed between the distal and proximal ends; and a longitudinally extending inner tubular member having distal and proximal ends, the inner tubular member being longitudinally and axially displaceable relative to the outer tubular member and wherein the distal end comprises a tip, the inner tubular member further comprises at least one catch along the longitudinal expanse thereof for operative interaction with the safety catch assembly of the longitudinally extending outer tubular member to limit extent of stent deployment;
inserting the deployment apparatus through a portion of the anatomy of a patient;
positioning the distal tip of the inner tubular member about a target area within the patient;
displacing the outer tubular member, with respect to the inner tubular member so as to expose the stent short of its full deployment position and deploying the stent such that the stent expands forming a lumen there through that is larger than the compressed diameter of the stent.
21. The method of claim 19, further comprising the step of:
removing the deployment apparatus through the lumen of the deployed stent.
CA002503563A 2002-10-26 2003-10-25 Medical appliance deployment apparatus and method of use Abandoned CA2503563A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/281,429 US20040093056A1 (en) 2002-10-26 2002-10-26 Medical appliance delivery apparatus and method of use
US10/281,429 2002-10-26
PCT/US2003/033967 WO2004039242A2 (en) 2002-10-26 2003-10-25 Medical appliance deployment apparatus and method of use

Publications (1)

Publication Number Publication Date
CA2503563A1 true CA2503563A1 (en) 2004-05-13

Family

ID=32228764

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002503563A Abandoned CA2503563A1 (en) 2002-10-26 2003-10-25 Medical appliance deployment apparatus and method of use

Country Status (6)

Country Link
US (3) US20040093056A1 (en)
EP (1) EP1553903A4 (en)
JP (1) JP4570957B2 (en)
AU (1) AU2003301732B2 (en)
CA (1) CA2503563A1 (en)
WO (1) WO2004039242A2 (en)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6254564B1 (en) 1998-09-10 2001-07-03 Percardia, Inc. Left ventricular conduit with blood vessel graft
US7018401B1 (en) 1999-02-01 2006-03-28 Board Of Regents, The University Of Texas System Woven intravascular devices and methods for making the same and apparatus for delivery of the same
US20040093056A1 (en) 2002-10-26 2004-05-13 Johnson Lianw M. Medical appliance delivery apparatus and method of use
US7637934B2 (en) 2003-03-31 2009-12-29 Merit Medical Systems, Inc. Medical appliance optical delivery and deployment apparatus and method
US7561916B2 (en) * 2005-06-24 2009-07-14 Ethicon Endo-Surgery, Inc. Implantable medical device with indicator
US8029477B2 (en) 2003-12-19 2011-10-04 Ethicon Endo-Surgery, Inc. Applier with safety for implantable medical device
US7862546B2 (en) * 2003-06-16 2011-01-04 Ethicon Endo-Surgery, Inc. Subcutaneous self attaching injection port with integral moveable retention members
US8715243B2 (en) * 2003-06-16 2014-05-06 Ethicon Endo-Surgery, Inc. Injection port applier with downward force actuation
US7967829B2 (en) * 2003-10-09 2011-06-28 Boston Scientific Scimed, Inc. Medical device delivery system
US8162897B2 (en) * 2003-12-19 2012-04-24 Ethicon Endo-Surgery, Inc. Audible and tactile feedback
DE102005003632A1 (en) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Catheter for the transvascular implantation of heart valve prostheses
US8702744B2 (en) * 2005-05-09 2014-04-22 Nexeon Medsystems, Inc. Apparatus and methods for renal stenting
US7731654B2 (en) 2005-05-13 2010-06-08 Merit Medical Systems, Inc. Delivery device with viewing window and associated method
US7918844B2 (en) 2005-06-24 2011-04-05 Ethicon Endo-Surgery, Inc. Applier for implantable medical device
US7651483B2 (en) * 2005-06-24 2010-01-26 Ethicon Endo-Surgery, Inc. Injection port
US8038704B2 (en) 2005-07-27 2011-10-18 Paul S. Sherburne Stent and other objects removal from a body
US20070100279A1 (en) * 2005-11-03 2007-05-03 Paragon Intellectual Properties, Llc Radiopaque-balloon microcatheter and methods of manufacture
US20080051867A1 (en) * 2006-08-28 2008-02-28 Davila Luis A Multiple in vivo implant delivery device
KR101297043B1 (en) 2006-10-22 2013-08-14 이데브 테크놀로지스, 아이엔씨. Methods for securing strand ends and the resulting devices
EP2083767B1 (en) 2006-10-22 2019-04-03 IDEV Technologies, INC. Devices for stent advancement
US9138315B2 (en) * 2007-04-13 2015-09-22 Jenavalve Technology Gmbh Medical device for treating a heart valve insufficiency or stenosis
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
EP2659861B1 (en) 2007-05-15 2019-03-13 JenaValve Technology, Inc. Handle for manipulating a catheter tip, catheter system and medical insertion system for inserting a self-expandable heart valve stent
US9180004B2 (en) 2008-01-16 2015-11-10 St. Jude Medical, Inc. Delivery and retrieval systems for collapsible/expandable prosthetic heart valves
US8858609B2 (en) 2008-02-07 2014-10-14 Intuitive Surgical Operations, Inc. Stent delivery under direct visualization
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
BR112012021347A2 (en) 2008-02-26 2019-09-24 Jenavalve Tecnology Inc stent for positioning and anchoring a valve prosthesis at an implantation site in a patient's heart
JP5596037B2 (en) * 2008-10-10 2014-09-24 バイオセンサーズ インターナショナル グループ、リミテッド Catheter system without equipment
WO2010091155A2 (en) 2009-02-05 2010-08-12 Synthes Usa, Llc Reamer and drill guiding device
DE102009050457A1 (en) * 2009-10-23 2011-05-05 Medi-Globe Vascutec Gmbh A surgical device for passing at least one suture through the edge region of a tissue opening of an individual and method for actuating such device
US9468435B2 (en) 2009-12-23 2016-10-18 Cook Medical Technologies Llc Wound closure device
US8926693B2 (en) * 2010-02-17 2015-01-06 Medtronic, Inc. Heart valve delivery catheter with safety button
KR101135154B1 (en) * 2010-02-19 2012-04-16 주식회사 라파스 Stent delivery devices using micro cadeter
CA2799459A1 (en) 2010-05-25 2011-12-01 Jenavalve Technology Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
US9023095B2 (en) 2010-05-27 2015-05-05 Idev Technologies, Inc. Stent delivery system with pusher assembly
AU2011335994A1 (en) * 2010-11-29 2013-06-06 Kyoto Medical Planning Co., Ltd. Medical catheter device
EP4098226A1 (en) 2013-08-30 2022-12-07 JenaValve Technology, Inc. Endoprosthesis comprising a radially collapsible frame and a prosthetic valve
EP3043754B1 (en) 2013-09-12 2020-02-12 Boston Scientific Scimed, Inc. Stent with anti-migration connectors
US10065029B2 (en) * 2014-03-03 2018-09-04 Cook Medical Technologies Llc Mechanical dilator
ES2678047T3 (en) 2014-03-18 2018-08-08 Boston Scientific Scimed, Inc. Stent design to reduce granulation and inflammation
US10016292B2 (en) 2014-04-18 2018-07-10 Covidien Lp Stent delivery system
EP3145453B1 (en) 2014-05-21 2021-01-20 Boston Scientific Scimed, Inc. Stent delivery system
WO2016054536A1 (en) 2014-10-02 2016-04-07 Boston Scientific Scimed, Inc. Controlled ingrowth feature for antimigration
CN107087399B (en) 2014-10-22 2020-05-12 心脏起搏器股份公司 Delivery device for leadless cardiac devices
CN106852124A (en) 2014-10-22 2017-06-13 心脏起搏器股份公司 For the delivery device and method of leadless cardiac equipment
JP2017530811A (en) 2014-10-22 2017-10-19 ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. Flexible hinged stent
WO2016073597A1 (en) 2014-11-06 2016-05-12 Boston Scientific Scimed, Inc. Tracheal stent
EP3632378A1 (en) 2015-05-01 2020-04-08 JenaValve Technology, Inc. Device and method with reduced pacemaker rate in heart valve replacement
CN108348759B (en) 2015-11-20 2021-08-17 心脏起搏器股份公司 Delivery devices and methods for leadless cardiac devices
WO2017087661A1 (en) 2015-11-20 2017-05-26 Cardiac Pacemakers, Inc. Delivery devices and methods for leadless cardiac devices
CN109475419B (en) 2016-05-13 2021-11-09 耶拿阀门科技股份有限公司 Heart valve prosthesis delivery systems and methods for delivering heart valve prostheses through guide sheaths and loading systems
US11198013B2 (en) 2016-11-21 2021-12-14 Cardiac Pacemakers, Inc. Catheter and leadless cardiac devices including electrical pathway barrier
WO2018094193A1 (en) 2016-11-21 2018-05-24 Cardiac Pacemakers, Inc. Delivery devices and wall apposition sensing
US10894162B2 (en) 2016-12-27 2021-01-19 Cardiac Pacemakers, Inc. Delivery devices and methods for leadless cardiac devices
US10485981B2 (en) 2016-12-27 2019-11-26 Cardiac Pacemakers, Inc. Fixation methods for leadless cardiac devices
WO2018125791A1 (en) 2016-12-27 2018-07-05 Cardiac Pacemakers, Inc. Leadless delivery catheter with conductive pathway
US10806931B2 (en) 2016-12-27 2020-10-20 Cardiac Pacemakers, Inc. Delivery devices and methods for leadless cardiac devices
JP6735427B2 (en) 2017-01-26 2020-08-05 カーディアック ペースメイカーズ, インコーポレイテッド Delivery device and delivery method for leadless heart device
EP3573579B1 (en) 2017-01-27 2023-12-20 JenaValve Technology, Inc. Heart valve mimicry
US11229798B2 (en) 2017-03-10 2022-01-25 Cardiac Pacemakers, Inc. Fixation for leadless cardiac devices
US10737092B2 (en) 2017-03-30 2020-08-11 Cardiac Pacemakers, Inc. Delivery devices and methods for leadless cardiac devices
US11577085B2 (en) 2017-08-03 2023-02-14 Cardiac Pacemakers, Inc. Delivery devices and methods for leadless cardiac devices
US11083609B2 (en) * 2018-04-24 2021-08-10 Medtronic Vascular, Inc. Selectable tip delivery system and method
US10441449B1 (en) 2018-05-30 2019-10-15 Vesper Medical, Inc. Rotary handle stent delivery system and method
US10449073B1 (en) 2018-09-18 2019-10-22 Vesper Medical, Inc. Rotary handle stent delivery system and method
CN113660977A (en) 2019-03-29 2021-11-16 心脏起搏器股份公司 System and method for treating cardiac arrhythmias
US11446510B2 (en) 2019-03-29 2022-09-20 Cardiac Pacemakers, Inc. Systems and methods for treating cardiac arrhythmias
KR102244846B1 (en) * 2019-04-18 2021-04-28 주식회사 엠아이텍 Stent delivery device
CN113939327A (en) * 2019-06-24 2022-01-14 美敦力公司 Catheter handle with torque mechanism and valve relief assembly
WO2021050679A1 (en) 2019-09-11 2021-03-18 Cardiac Pacemakers, Inc. Tools and systems for implanting and/or retrieving a leadless cardiac pacing device with helix fixation
US11571582B2 (en) 2019-09-11 2023-02-07 Cardiac Pacemakers, Inc. Tools and systems for implanting and/or retrieving a leadless cardiac pacing device with helix fixation
EP4090296A1 (en) 2020-01-13 2022-11-23 Boston Scientific Scimed Inc. Anti-migration stent
US11219541B2 (en) 2020-05-21 2022-01-11 Vesper Medical, Inc. Wheel lock for thumbwheel actuated device

Family Cites Families (331)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3196876A (en) * 1961-05-10 1965-07-27 Maurice M Miller Dilator
GB2056023B (en) 1979-08-06 1983-08-10 Ross D N Bodnar E Stent for a cardiac valve
US4680031A (en) 1982-11-29 1987-07-14 Tascon Medical Technology Corporation Heart valve prosthesis
US4606330A (en) * 1983-08-09 1986-08-19 Richard Wolf Gmbh Device for disintegrating stones in bodily cavities or ducts
US5067957A (en) 1983-10-14 1991-11-26 Raychem Corporation Method of inserting medical devices incorporating SIM alloy elements
US5190546A (en) 1983-10-14 1993-03-02 Raychem Corporation Medical devices incorporating SIM alloy elements
US4665906A (en) 1983-10-14 1987-05-19 Raychem Corporation Medical devices incorporating sim alloy elements
US4733665C2 (en) * 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US5102417A (en) * 1985-11-07 1992-04-07 Expandable Grafts Partnership Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft
US4820262A (en) * 1985-12-12 1989-04-11 Medical Engineering Corporation Ureteral stent
US4893623A (en) * 1986-12-09 1990-01-16 Advanced Surgical Intervention, Inc. Method and apparatus for treating hypertrophy of the prostate gland
US5032128A (en) 1988-07-07 1991-07-16 Medtronic, Inc. Heart valve prosthesis
US5249585A (en) * 1988-07-28 1993-10-05 Bsd Medical Corporation Urethral inserted applicator for prostate hyperthermia
SE8803444D0 (en) * 1988-09-28 1988-09-28 Medinvent Sa A DEVICE FOR TRANSLUMINAL IMPLANTATION OR EXTRACTION
CA1322628C (en) * 1988-10-04 1993-10-05 Richard A. Schatz Expandable intraluminal graft
US4957479A (en) 1988-10-17 1990-09-18 Vance Products Incorporated Indwelling ureteral stent placement apparatus
US5019085A (en) * 1988-10-25 1991-05-28 Cordis Corporation Apparatus and method for placement of a stent within a subject vessel
US4856516A (en) 1989-01-09 1989-08-15 Cordis Corporation Endovascular stent apparatus and method
US5292331A (en) * 1989-08-24 1994-03-08 Applied Vascular Engineering, Inc. Endovascular support device
IE73670B1 (en) * 1989-10-02 1997-07-02 Medtronic Inc Articulated stent
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
CA2078685C (en) * 1990-03-21 1996-07-09 Edwin Lerch Process and device for detecting the load angle of a generator connected to an electric supply network
US5159920A (en) * 1990-06-18 1992-11-03 Mentor Corporation Scope and stent system
US5356423A (en) 1991-01-04 1994-10-18 American Medical Systems, Inc. Resectable self-expanding stent
US5409453A (en) * 1992-08-12 1995-04-25 Vidamed, Inc. Steerable medical probe with stylets
US5073694A (en) 1991-02-21 1991-12-17 Synthes (U.S.A.) Method and apparatus for laser cutting a hollow metal workpiece
US5591172A (en) 1991-06-14 1997-01-07 Ams Medinvent S.A. Transluminal implantation device
US6029671A (en) * 1991-07-16 2000-02-29 Heartport, Inc. System and methods for performing endovascular procedures
US5443498A (en) 1991-10-01 1995-08-22 Cook Incorporated Vascular stent and method of making and implanting a vacsular stent
US5876445A (en) * 1991-10-09 1999-03-02 Boston Scientific Corporation Medical stents for body lumens exhibiting peristaltic motion
US5662713A (en) 1991-10-09 1997-09-02 Boston Scientific Corporation Medical stents for body lumens exhibiting peristaltic motion
US5354309A (en) 1991-10-11 1994-10-11 Angiomed Ag Apparatus for widening a stenosis in a body cavity
ES2109969T3 (en) * 1991-10-11 1998-02-01 Angiomed Ag PROCEDURE FOR THE DILATION OF A STENOSIS.
CA2380683C (en) 1991-10-28 2006-08-08 Advanced Cardiovascular Systems, Inc. Expandable stents and method for making same
FR2683449A1 (en) * 1991-11-08 1993-05-14 Cardon Alain ENDOPROTHESIS FOR TRANSLUMINAL IMPLANTATION.
US5201757A (en) * 1992-04-03 1993-04-13 Schneider (Usa) Inc. Medial region deployment of radially self-expanding stents
US5817102A (en) 1992-05-08 1998-10-06 Schneider (Usa) Inc. Apparatus for delivering and deploying a stent
EP0888758B1 (en) * 1992-05-08 2003-08-20 Schneider (Usa) Inc. Esophageal stent
CA2149887A1 (en) * 1992-12-30 1994-07-21 Steven J. Healy Apparatus for deploying body implantable stents
WO1994017856A1 (en) * 1993-02-02 1994-08-18 Vidamed, Inc. Transurethral needle ablation device and method
DE4303181A1 (en) * 1993-02-04 1994-08-11 Angiomed Ag Implantable catheter
ATE306230T1 (en) 1993-03-11 2005-10-15 Medinol Ltd STENT
US5345057A (en) 1993-03-25 1994-09-06 Lasag Ag Method of cutting an aperture in a device by means of a laser beam
EP0702535B1 (en) * 1993-04-13 2003-01-08 Boston Scientific Corporation Prosthesis delivery system with dilating tip
WO1994023786A1 (en) * 1993-04-13 1994-10-27 Boston Scientific Corporation Prosthesis delivery system
ES2114964T3 (en) 1993-04-23 1998-06-16 Schneider Europ Ag ENDOPROTESIS WITH A COAT OF ELASTIC MATERIAL COATING AND METHOD FOR APPLYING THE COAT ON ENDOPROTESIS.
US5480423A (en) * 1993-05-20 1996-01-02 Boston Scientific Corporation Prosthesis delivery
CH686923A5 (en) * 1993-06-22 1996-08-15 Crina A composition for improving the digestibility of feed for ruminant animals.
US5320617A (en) * 1993-06-25 1994-06-14 Leach Gary E Method of laser-assisted prostatectomy and apparatus for carrying out the method
US6689158B1 (en) * 1993-09-30 2004-02-10 Endogad Research Pty Limited Intraluminal graft
US5588949A (en) * 1993-10-08 1996-12-31 Heartport, Inc. Stereoscopic percutaneous visualization system
DE69419877T2 (en) 1993-11-04 1999-12-16 Bard Inc C R Fixed vascular prosthesis
RU2089131C1 (en) 1993-12-28 1997-09-10 Сергей Апполонович Пульнев Stent-expander
US5609627A (en) 1994-02-09 1997-03-11 Boston Scientific Technology, Inc. Method for delivering a bifurcated endoluminal prosthesis
US5443477A (en) * 1994-02-10 1995-08-22 Stentco, Inc. Apparatus and method for deployment of radially expandable stents by a mechanical linkage
DE69514690T3 (en) 1994-02-25 2006-09-14 Fischell, Robert E. stent
US5643312A (en) 1994-02-25 1997-07-01 Fischell Robert Stent having a multiplicity of closed circular structures
IL108832A (en) * 1994-03-03 1999-12-31 Medinol Ltd Urological stent and deployment device therefor
US5733303A (en) * 1994-03-17 1998-03-31 Medinol Ltd. Flexible expandable stent
US5843120A (en) 1994-03-17 1998-12-01 Medinol Ltd. Flexible-expandable stent
US6464722B2 (en) 1994-03-17 2002-10-15 Medinol, Ltd. Flexible expandable stent
US6461381B2 (en) 1994-03-17 2002-10-08 Medinol, Ltd. Flexible expandable stent
US5449373A (en) 1994-03-17 1995-09-12 Medinol Ltd. Articulated stent
US5746692A (en) * 1994-05-05 1998-05-05 Imagen Medical, Inc. Catheter and endoscope system with distal protruding ball tip and method
US5514093A (en) * 1994-05-19 1996-05-07 Scimed Life Systems, Inc. Variable length balloon dilatation catheter
DE4418336A1 (en) * 1994-05-26 1995-11-30 Angiomed Ag Stent for widening and holding open receptacles
US5683451A (en) 1994-06-08 1997-11-04 Cardiovascular Concepts, Inc. Apparatus and methods for deployment release of intraluminal prostheses
EP1520557A3 (en) 1994-06-08 2010-07-21 Cardiovascular Concepts, Inc. Apparatus and methods for endoluminal graft placement
US5591157A (en) * 1994-09-07 1997-01-07 Hennings; David R. Method and apparatus for tympanic membrane shrinkage
AU708360B2 (en) 1994-09-15 1999-08-05 C.R. Bard Inc. Hooked endoprosthesis
US5601591A (en) * 1994-09-23 1997-02-11 Vidamed, Inc. Stent for use in prostatic urethra, apparatus and placement device for same and method
US6746482B2 (en) 1994-10-17 2004-06-08 Baxter International Inc. Method for producing medical devices and devices so produced
JPH10507090A (en) * 1994-10-20 1998-07-14 インステント インコーポレーテッド Cystoscope delivery system
US5836964A (en) 1996-10-30 1998-11-17 Medinol Ltd. Stent fabrication method
WO1996013228A1 (en) 1994-10-27 1996-05-09 Schneider (Usa) Inc. Stent delivery device
CA2134997C (en) 1994-11-03 2009-06-02 Ian M. Penn Stent
CA2301351C (en) 1994-11-28 2002-01-22 Advanced Cardiovascular Systems, Inc. Method and apparatus for direct laser cutting of metal stents
DE4446036C2 (en) 1994-12-23 1999-06-02 Ruesch Willy Ag Placeholder for placement in a body tube
AU719980B2 (en) 1995-02-22 2000-05-18 Menlo Care, Inc. Covered expanding mesh stent
US7204848B1 (en) 1995-03-01 2007-04-17 Boston Scientific Scimed, Inc. Longitudinally flexible expandable stent
DE19508805C2 (en) * 1995-03-06 2000-03-30 Lutz Freitag Stent for placement in a body tube with a flexible support structure made of at least two wires with different shape memory functions
US6451047B2 (en) 1995-03-10 2002-09-17 Impra, Inc. Encapsulated intraluminal stent-graft and methods of making same
US6579314B1 (en) 1995-03-10 2003-06-17 C.R. Bard, Inc. Covered stent with encapsulated ends
US5591197A (en) 1995-03-14 1997-01-07 Advanced Cardiovascular Systems, Inc. Expandable stent forming projecting barbs and method for deploying
DK0734698T4 (en) * 1995-04-01 2006-07-03 Variomed Ag Stent for transluminal implantation in hollow organs
US6325790B1 (en) * 1995-04-11 2001-12-04 Cordis Corporation Soft tip catheter
BE1009278A3 (en) * 1995-04-12 1997-01-07 Corvita Europ Guardian self-expandable medical device introduced in cavite body, and medical device with a stake as.
US5837313A (en) 1995-04-19 1998-11-17 Schneider (Usa) Inc Drug release stent coating process
DE69633263T2 (en) * 1995-05-25 2005-09-08 Medtronic, Inc., Minneapolis STENT ARRANGEMENT
US5593442A (en) * 1995-06-05 1997-01-14 Localmed, Inc. Radially expansible and articulated vessel scaffold
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
CA2178541C (en) * 1995-06-07 2009-11-24 Neal E. Fearnot Implantable medical device
US6774278B1 (en) 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
US5769882A (en) * 1995-09-08 1998-06-23 Medtronic, Inc. Methods and apparatus for conformably sealing prostheses within body lumens
US5702418A (en) 1995-09-12 1997-12-30 Boston Scientific Corporation Stent delivery system
US5776161A (en) 1995-10-16 1998-07-07 Instent, Inc. Medical stents, apparatus and method for making same
US6428538B1 (en) * 1995-10-20 2002-08-06 United States Surgical Corporation Apparatus and method for thermal treatment of body tissue
US5628788A (en) 1995-11-07 1997-05-13 Corvita Corporation Self-expanding endoluminal stent-graft
DE19547538C2 (en) * 1995-12-20 1999-09-23 Ruesch Willy Ag Instrument for use in interventional flexible tracheoscopy / bronchoscopy
US6719782B1 (en) 1996-01-04 2004-04-13 Endovascular Technologies, Inc. Flat wire stent
IL125417A (en) 1996-02-02 2004-03-28 Transvascular Inc Apparatus for blocking flow through blood vessels
CA2248718A1 (en) 1996-03-05 1997-09-12 Divysio Solutions Ulc. Expandable stent and method for delivery of same
US6796997B1 (en) 1996-03-05 2004-09-28 Evysio Medical Devices Ulc Expandable stent
CA2192520A1 (en) * 1996-03-05 1997-09-05 Ian M. Penn Expandable stent and method for delivery of same
CA2199890C (en) 1996-03-26 2002-02-05 Leonard Pinchuk Stents and stent-grafts having enhanced hoop strength and methods of making the same
US6533805B1 (en) * 1996-04-01 2003-03-18 General Surgical Innovations, Inc. Prosthesis and method for deployment within a body lumen
US5824042A (en) * 1996-04-05 1998-10-20 Medtronic, Inc. Endoluminal prostheses having position indicating markers
US5713949A (en) * 1996-08-06 1998-02-03 Jayaraman; Swaminathan Microporous covered stents and method of coating
US5830179A (en) 1996-04-09 1998-11-03 Endocare, Inc. Urological stent therapy system and method
US6629981B2 (en) * 2000-07-06 2003-10-07 Endocare, Inc. Stent delivery system
JP4636634B2 (en) 1996-04-26 2011-02-23 ボストン サイエンティフィック サイムド,インコーポレイテッド Intravascular stent
US6251133B1 (en) * 1996-05-03 2001-06-26 Medinol Ltd. Bifurcated stent with improved side branch aperture and method of making same
UA58485C2 (en) 1996-05-03 2003-08-15 Медінол Лтд. Method for manufacture of bifurcated stent (variants) and bifurcated stent (variants)
MX9800715A (en) 1996-05-31 1998-04-30 Bard Walway Ltd Bifurcated endovascular stents and method and apparatus for their placement.
US8728143B2 (en) 1996-06-06 2014-05-20 Biosensors International Group, Ltd. Endoprosthesis deployment system for treating vascular bifurcations
US5776140A (en) * 1996-07-16 1998-07-07 Cordis Corporation Stent delivery system
US5922020A (en) 1996-08-02 1999-07-13 Localmed, Inc. Tubular prosthesis having improved expansion and imaging characteristics
US6174329B1 (en) * 1996-08-22 2001-01-16 Advanced Cardiovascular Systems, Inc. Protective coating for a stent with intermediate radiopaque coating
US6391032B2 (en) * 1996-08-23 2002-05-21 Scimed Life Systems, Inc. Stent delivery system having stent securement means
AU739710B2 (en) * 1996-08-23 2001-10-18 Boston Scientific Limited Stent delivery system having stent securement apparatus
US5797887A (en) 1996-08-27 1998-08-25 Novovasc Llc Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation
US5807404A (en) * 1996-09-19 1998-09-15 Medinol Ltd. Stent with variable features to optimize support and method of making such stent
ATE309762T1 (en) * 1996-09-26 2005-12-15 Scimed Life Systems Inc COMBINED MEDICAL DEVICE CONSISTING OF A SUPPORT STRUCTURE AND A MEMBRANE
US5755776A (en) 1996-10-04 1998-05-26 Al-Saadon; Khalid Permanent expandable intraluminal tubular stent
US5868781A (en) * 1996-10-22 1999-02-09 Scimed Life Systems, Inc. Locking stent
US6325826B1 (en) * 1998-01-14 2001-12-04 Advanced Stent Technologies, Inc. Extendible stent apparatus
US6692483B2 (en) * 1996-11-04 2004-02-17 Advanced Stent Technologies, Inc. Catheter with attached flexible side sheath
WO1998020810A1 (en) 1996-11-12 1998-05-22 Medtronic, Inc. Flexible, radially expansible luminal prostheses
US6395017B1 (en) 1996-11-15 2002-05-28 C. R. Bard, Inc. Endoprosthesis delivery catheter with sequential stage control
US5968052A (en) * 1996-11-27 1999-10-19 Scimed Life Systems Inc. Pull back stent delivery system with pistol grip retraction handle
EP0946222A1 (en) 1996-12-13 1999-10-06 Data Sciences International, Inc. Biocompatible medical devices with polyurethane surface
US5868782A (en) 1996-12-24 1999-02-09 Global Therapeutics, Inc. Radially expandable axially non-contracting surgical stent
US5906759A (en) * 1996-12-26 1999-05-25 Medinol Ltd. Stent forming apparatus with stent deforming blades
IT1289815B1 (en) 1996-12-30 1998-10-16 Sorin Biomedica Cardio Spa ANGIOPLASTIC STENT AND RELATED PRODUCTION PROCESS
US5876400A (en) 1997-01-13 1999-03-02 Pioneer Laboratories, Inc. Electrocautery method and apparatus
US6152956A (en) * 1997-01-28 2000-11-28 Pierce; George E. Prosthesis for endovascular repair of abdominal aortic aneurysms
US5827321A (en) 1997-02-07 1998-10-27 Cornerstone Devices, Inc. Non-Foreshortening intraluminal prosthesis
US5911732A (en) 1997-03-10 1999-06-15 Johnson & Johnson Interventional Systems, Co. Articulated expandable intraluminal stent
US5902475A (en) 1997-04-08 1999-05-11 Interventional Technologies, Inc. Method for manufacturing a stent
US6240616B1 (en) 1997-04-15 2001-06-05 Advanced Cardiovascular Systems, Inc. Method of manufacturing a medicated porous metal prosthesis
US6776792B1 (en) 1997-04-24 2004-08-17 Advanced Cardiovascular Systems Inc. Coated endovascular stent
US6033433A (en) 1997-04-25 2000-03-07 Scimed Life Systems, Inc. Stent configurations including spirals
US6451049B2 (en) 1998-04-29 2002-09-17 Sorin Biomedica Cardio, S.P.A. Stents for angioplasty
DE19718339A1 (en) * 1997-04-30 1998-11-12 Schering Ag Polymer coated stents, processes for their manufacture and their use for restenosis prophylaxis
DE29708803U1 (en) * 1997-05-17 1997-07-31 Jomed Implantate Gmbh Radially expandable stent for implantation in a body vessel in the area of a vascular branch
DE29708879U1 (en) * 1997-05-20 1997-07-31 Jomed Implantate Gmbh Coronary stent
US5836966A (en) 1997-05-22 1998-11-17 Scimed Life Systems, Inc. Variable expansion force stent
BE1011180A6 (en) * 1997-05-27 1999-06-01 Medicorp R & D Benelux Sa Luminal endoprosthesis AUTO EXPANDABLE.
US6723121B1 (en) 1997-06-18 2004-04-20 Scimed Life Systems, Inc. Polycarbonate-polyurethane dispersions for thrombo-resistant coatings
US6165195A (en) 1997-08-13 2000-12-26 Advanced Cardiovascylar Systems, Inc. Stent and catheter assembly and method for treating bifurcations
US6316522B1 (en) 1997-08-18 2001-11-13 Scimed Life Systems, Inc. Bioresorbable hydrogel compositions for implantable prostheses
US6086528A (en) * 1997-09-11 2000-07-11 Adair; Edwin L. Surgical devices with removable imaging capability and methods of employing same
US6746476B1 (en) 1997-09-22 2004-06-08 Cordis Corporation Bifurcated axially flexible stent
JP4292710B2 (en) 1997-09-24 2009-07-08 エム イー ディ インスチィチュート インク Radially expandable stent
DE29718773U1 (en) * 1997-10-22 1997-12-04 Stocko Metallwarenfab Henkels Chip card contact unit
US6033435A (en) * 1997-11-03 2000-03-07 Divysio Solutions Ulc Bifurcated stent and method for the manufacture and delivery of same
NO311781B1 (en) 1997-11-13 2002-01-28 Medinol Ltd Metal multilayer stents
US6330884B1 (en) 1997-11-14 2001-12-18 Transvascular, Inc. Deformable scaffolding multicellular stent
US6179867B1 (en) * 1998-01-16 2001-01-30 Advanced Cardiovascular Systems, Inc. Flexible stent and method of use
EP0945107A3 (en) 1998-01-23 2000-01-19 Arterial Vascular Engineering, Inc. Helical stent
US6533807B2 (en) 1998-02-05 2003-03-18 Medtronic, Inc. Radially-expandable stent and delivery system
US6488701B1 (en) * 1998-03-31 2002-12-03 Medtronic Ave, Inc. Stent-graft assembly with thin-walled graft component and method of manufacture
US5938697A (en) 1998-03-04 1999-08-17 Scimed Life Systems, Inc. Stent having variable properties
EP2198813B1 (en) 1998-03-05 2012-08-29 Boston Scientific Limited Intraluminal stent
US6019778A (en) * 1998-03-13 2000-02-01 Cordis Corporation Delivery apparatus for a self-expanding stent
US5935162A (en) 1998-03-16 1999-08-10 Medtronic, Inc. Wire-tubular hybrid stent
US6132461A (en) 1998-03-27 2000-10-17 Intratherapeutics, Inc. Stent with dual support structure
EP1067882A1 (en) * 1998-03-31 2001-01-17 Salviac Limited A delivery catheter
AU751056B2 (en) * 1998-04-02 2002-08-08 Salviac Limited Delivery catheter
JP4583597B2 (en) 1998-05-05 2010-11-17 ボストン サイエンティフィック リミテッド Smooth end stent
US6780199B2 (en) * 1998-05-15 2004-08-24 Advanced Cardiovascular Systems, Inc. Enhanced stent delivery system
DE19822157B4 (en) 1998-05-16 2013-01-10 Abbott Laboratories Vascular Enterprises Ltd. Radially expandable stent for implantation in a body vessel
US6740113B2 (en) 1998-05-29 2004-05-25 Scimed Life Systems, Inc. Balloon expandable stent with a self-expanding portion
CA2334223C (en) 1998-06-04 2008-11-18 New York University Endovascular thin film devices and methods for treating and preventing stroke
KR20010072816A (en) 1998-08-20 2001-07-31 쿡 인코포레이티드 Coated implantable medical device
US6193744B1 (en) 1998-09-10 2001-02-27 Scimed Life Systems, Inc. Stent configurations
US6162231A (en) * 1998-09-14 2000-12-19 Endocare, Inc. Stent insertion device
US6093194A (en) * 1998-09-14 2000-07-25 Endocare, Inc. Insertion device for stents and methods for use
CA2344252A1 (en) * 1998-09-18 2000-03-30 United States Surgical Corporation Endovascular fastener applicator
US6432126B1 (en) 1998-09-30 2002-08-13 C.R. Bard, Inc. Flexible vascular inducing implants
US6203550B1 (en) * 1998-09-30 2001-03-20 Medtronic, Inc. Disposable delivery device for endoluminal prostheses
JP2002525168A (en) * 1998-09-30 2002-08-13 インプラ・インコーポレーテッド Introduction mechanism of implantable stent
US6042597A (en) * 1998-10-23 2000-03-28 Scimed Life Systems, Inc. Helical stent design
US6475234B1 (en) 1998-10-26 2002-11-05 Medinol, Ltd. Balloon expandable covered stents
EP1128865A4 (en) 1998-11-11 2005-11-23 Mark Wilson Ian Webster Bifurcation stent and delivery systems
US6733523B2 (en) 1998-12-11 2004-05-11 Endologix, Inc. Implantable vascular graft
US6660030B2 (en) 1998-12-11 2003-12-09 Endologix, Inc. Bifurcation graft deployment catheter
US6383204B1 (en) 1998-12-15 2002-05-07 Micrus Corporation Variable stiffness coil for vasoocclusive devices
US6530950B1 (en) 1999-01-12 2003-03-11 Quanam Medical Corporation Intraluminal stent having coaxial polymer member
US6454789B1 (en) 1999-01-15 2002-09-24 Light Science Corporation Patient portable device for photodynamic therapy
US6673102B1 (en) * 1999-01-22 2004-01-06 Gore Enterprises Holdings, Inc. Covered endoprosthesis and delivery system
US6361557B1 (en) * 1999-02-05 2002-03-26 Medtronic Ave, Inc. Staplebutton radiopaque marker
US6695876B1 (en) * 1999-02-12 2004-02-24 Thomas R. Marotta Endovascular prosthesis
DE19906956B4 (en) 1999-02-19 2011-07-21 QualiMed Innovative Medizin-Produkte GmbH, 21423 Stent and method for producing a stent
US6514245B1 (en) * 1999-03-15 2003-02-04 Cryovascular Systems, Inc. Safety cryotherapy catheter
US6248122B1 (en) 1999-02-26 2001-06-19 Vascular Architects, Inc. Catheter with controlled release endoluminal prosthesis
US6364903B2 (en) 1999-03-19 2002-04-02 Meadox Medicals, Inc. Polymer coated stent
EP1173110B1 (en) 1999-04-15 2009-07-08 Smart Therapeutics, Inc. Intravascular stent for treating neurovascular vessel lesion
US6730116B1 (en) 1999-04-16 2004-05-04 Medtronic, Inc. Medical device for intraluminal endovascular stenting
US6726712B1 (en) * 1999-05-14 2004-04-27 Boston Scientific Scimed Prosthesis deployment device with translucent distal end
US6375676B1 (en) * 1999-05-17 2002-04-23 Advanced Cardiovascular Systems, Inc. Self-expanding stent with enhanced delivery precision and stent delivery system
US6673103B1 (en) * 1999-05-20 2004-01-06 Scimed Life Systems, Inc. Mesh and stent for increased flexibility
WO2000071058A1 (en) 1999-05-20 2000-11-30 Boston Scientific Limited Stent delivery system with nested stabilizer and method of loading and using same
US6398802B1 (en) 1999-06-21 2002-06-04 Scimed Life Systems, Inc. Low profile delivery system for stent and graft deployment
US6193686B1 (en) * 1999-06-30 2001-02-27 Advanced Cardiovascular Systems, Inc. Catheter with enhanced flexibility
US6440161B1 (en) * 1999-07-07 2002-08-27 Endologix, Inc. Dual wire placement catheter
EP1068879A3 (en) 1999-07-13 2003-09-17 Terumo Kabushiki Kaisha Apparatus for thermotherapy
DE19937638B4 (en) 1999-08-12 2006-11-02 Alveolus Inc. Tracheal Stent
KR100341019B1 (en) 1999-08-18 2002-06-20 신경민 The flexible self- expandable stent foundation device
US6299622B1 (en) 1999-08-19 2001-10-09 Fox Hollow Technologies, Inc. Atherectomy catheter with aligned imager
US6790228B2 (en) 1999-12-23 2004-09-14 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
US6695809B1 (en) * 1999-09-13 2004-02-24 Advanced Cardiovascular Systems, Inc. Catheter balloon with a discontinuous elastomeric outer layer
US6383213B2 (en) 1999-10-05 2002-05-07 Advanced Cardiovascular Systems, Inc. Stent and catheter assembly and method for treating bifurcations
US6331189B1 (en) 1999-10-18 2001-12-18 Medtronic, Inc. Flexible medical stent
DE19951477A1 (en) 1999-10-26 2001-05-03 Biotronik Mess & Therapieg Stent
US6679910B1 (en) * 1999-11-12 2004-01-20 Latin American Devices Llc Intraluminal stent
WO2001035715A2 (en) * 1999-11-18 2001-05-25 Petrus Besselink Method for placing bifurcated stents
US6280466B1 (en) 1999-12-03 2001-08-28 Teramed Inc. Endovascular graft system
US6673107B1 (en) * 1999-12-06 2004-01-06 Advanced Cardiovascular Systems, Inc. Bifurcated stent and method of making
US6387120B2 (en) 1999-12-09 2002-05-14 Advanced Cardiovascular Systems, Inc. Stent and catheter assembly and method for treating bifurcations
US6702849B1 (en) * 1999-12-13 2004-03-09 Advanced Cardiovascular Systems, Inc. Method of processing open-celled microcellular polymeric foams with controlled porosity for use as vascular grafts and stent covers
US6942674B2 (en) 2000-01-05 2005-09-13 Integrated Vascular Systems, Inc. Apparatus and methods for delivering a closure device
US6322586B1 (en) * 2000-01-10 2001-11-27 Scimed Life Systems, Inc. Catheter tip designs and method of manufacture
US6723113B1 (en) * 2000-01-19 2004-04-20 Cordis Neurovascular, Inc. Inflatable balloon catheter seal and method
US6355063B1 (en) 2000-01-20 2002-03-12 Impra, Inc. Expanded PTFE drug delivery graft
US6344044B1 (en) * 2000-02-11 2002-02-05 Edwards Lifesciences Corp. Apparatus and methods for delivery of intraluminal prosthesis
US6929658B1 (en) * 2000-03-09 2005-08-16 Design & Performance-Cyprus Limited Stent with cover connectors
US6736838B1 (en) 2000-03-22 2004-05-18 Zuli Holdings Ltd. Method and apparatus for covering a stent
GB0009030D0 (en) 2000-04-12 2000-05-31 Angiomed Ag Self-expanding metal stent and method of making it
US6626902B1 (en) 2000-04-12 2003-09-30 University Of Virginia Patent Foundation Multi-probe system
JP3654627B2 (en) 2000-04-20 2005-06-02 川澄化学工業株式会社 Stent
US6776796B2 (en) 2000-05-12 2004-08-17 Cordis Corportation Antiinflammatory drug and delivery device
US6764519B2 (en) 2000-05-26 2004-07-20 Scimed Life Systems, Inc. Ureteral stent
US20030139803A1 (en) 2000-05-30 2003-07-24 Jacques Sequin Method of stenting a vessel with stent lumenal diameter increasing distally
US6800089B1 (en) 2000-05-31 2004-10-05 Advanced Cardiovascular Systems, Inc. Mechanical attachment method of cover materials on stents
US6572646B1 (en) 2000-06-02 2003-06-03 Advanced Cardiovascular Systems, Inc. Curved nitinol stent for extremely tortuous anatomy
CA2411944C (en) 2000-06-09 2010-12-14 Baylor College Of Medicine The combination of antimicrobial agents and bacterial interference to coat medical devices
US6723373B1 (en) 2000-06-16 2004-04-20 Cordis Corporation Device and process for coating stents
US6805704B1 (en) 2000-06-26 2004-10-19 C. R. Bard, Inc. Intraluminal stents
US6540775B1 (en) * 2000-06-30 2003-04-01 Cordis Corporation Ultraflexible open cell stent
US6709451B1 (en) * 2000-07-14 2004-03-23 Norman Noble, Inc. Channeled vascular stent apparatus and method
US6440162B1 (en) 2000-07-26 2002-08-27 Advanced Cardiovascular Systems, Inc. Stent having increased scaffolding expandable bar arms
US6808533B1 (en) 2000-07-28 2004-10-26 Atrium Medical Corporation Covered stent and method of covering a stent
US6613078B1 (en) 2000-08-02 2003-09-02 Hector Daniel Barone Multi-component endoluminal graft assembly, use thereof and method of implanting
US6773446B1 (en) * 2000-08-02 2004-08-10 Cordis Corporation Delivery apparatus for a self-expanding stent
NO312223B1 (en) 2000-09-05 2002-04-15 Leiv Eiriksson Nyfotek As Coated expandable stent
US6554841B1 (en) 2000-09-22 2003-04-29 Scimed Life Systems, Inc. Striped sleeve for stent delivery
US20020072792A1 (en) 2000-09-22 2002-06-13 Robert Burgermeister Stent with optimal strength and radiopacity characteristics
US6695833B1 (en) * 2000-09-27 2004-02-24 Nellix, Inc. Vascular stent-graft apparatus and forming method
US6805898B1 (en) 2000-09-28 2004-10-19 Advanced Cardiovascular Systems, Inc. Surface features of an implantable medical device
US6736828B1 (en) * 2000-09-29 2004-05-18 Scimed Life Systems, Inc. Method for performing endoluminal fundoplication and apparatus for use in the method
US6485508B1 (en) 2000-10-13 2002-11-26 Mcguinness Colm P. Low profile stent
US6764507B2 (en) 2000-10-16 2004-07-20 Conor Medsystems, Inc. Expandable medical device with improved spatial distribution
US6786918B1 (en) 2000-10-17 2004-09-07 Medtronic Vascular, Inc. Stent delivery system
US6656211B1 (en) 2000-10-26 2003-12-02 Scimed Life Systems, Inc. Stent delivery system with improved tracking
US6663664B1 (en) 2000-10-26 2003-12-16 Advanced Cardiovascular Systems, Inc. Self-expanding stent with time variable radial force
US6758859B1 (en) 2000-10-30 2004-07-06 Kenny L. Dang Increased drug-loading and reduced stress drug delivery device
US6761708B1 (en) * 2000-10-31 2004-07-13 Advanced Cardiovascular Systems, Inc. Radiopaque marker for a catheter and method of making
US6770086B1 (en) 2000-11-02 2004-08-03 Scimed Life Systems, Inc. Stent covering formed of porous polytetraflouroethylene
AU2002233936A1 (en) * 2000-11-07 2002-05-21 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal stent, self-fupporting endoluminal graft and methods of making same
US6843802B1 (en) * 2000-11-16 2005-01-18 Cordis Corporation Delivery apparatus for a self expanding retractable stent
US6664335B2 (en) 2000-11-30 2003-12-16 Cardiac Pacemakers, Inc. Polyurethane elastomer article with “shape memory” and medical devices therefrom
US6569085B2 (en) * 2001-08-16 2003-05-27 Syntheon, Llc Methods and apparatus for delivering a medical instrument over an endoscope while the endoscope is in a body lumen
US6589214B2 (en) * 2000-12-06 2003-07-08 Rex Medical, L.P. Vascular introducer sheath with retainer
US6645242B1 (en) 2000-12-11 2003-11-11 Stephen F. Quinn Bifurcated side-access intravascular stent graft
US6565599B1 (en) 2000-12-28 2003-05-20 Advanced Cardiovascular Systems, Inc. Hybrid stent
US6569194B1 (en) 2000-12-28 2003-05-27 Advanced Cardiovascular Systems, Inc. Thermoelastic and superelastic Ni-Ti-W alloy
US6641607B1 (en) 2000-12-29 2003-11-04 Advanced Cardiovascular Systems, Inc. Double tube stent
US6749627B2 (en) * 2001-01-18 2004-06-15 Ev3 Peripheral, Inc. Grip for stent delivery system
US6623491B2 (en) * 2001-01-18 2003-09-23 Ev3 Peripheral, Inc. Stent delivery system with spacer member
US6699274B2 (en) * 2001-01-22 2004-03-02 Scimed Life Systems, Inc. Stent delivery system and method of manufacturing same
US6899727B2 (en) 2001-01-22 2005-05-31 Gore Enterprise Holdings, Inc. Deployment system for intraluminal devices
US6752829B2 (en) 2001-01-30 2004-06-22 Scimed Life Systems, Inc. Stent with channel(s) for containing and delivering a biologically active material and method for manufacturing the same
US6802846B2 (en) * 2001-02-12 2004-10-12 Ams Research Corporation Foreign body retrieval device and method
US6540777B2 (en) 2001-02-15 2003-04-01 Scimed Life Systems, Inc. Locking stent
US6679911B2 (en) * 2001-03-01 2004-01-20 Cordis Corporation Flexible stent
US6740114B2 (en) 2001-03-01 2004-05-25 Cordis Corporation Flexible stent
US6790227B2 (en) 2001-03-01 2004-09-14 Cordis Corporation Flexible stent
US6592549B2 (en) * 2001-03-14 2003-07-15 Scimed Life Systems, Inc. Rapid exchange stent delivery system and associated components
US6673104B2 (en) * 2001-03-15 2004-01-06 Scimed Life Systems, Inc. Magnetic stent
US6673105B1 (en) * 2001-04-02 2004-01-06 Advanced Cardiovascular Systems, Inc. Metal prosthesis coated with expandable ePTFE
US6756007B2 (en) 2001-04-04 2004-06-29 Bard Peripheral Vascular, Inc. Method for preparing an implantable prosthesis for loading into a delivery apparatus
US6733521B2 (en) * 2001-04-11 2004-05-11 Trivascular, Inc. Delivery system and method for endovascular graft
US6761733B2 (en) 2001-04-11 2004-07-13 Trivascular, Inc. Delivery system and method for bifurcated endovascular graft
US6764505B1 (en) 2001-04-12 2004-07-20 Advanced Cardiovascular Systems, Inc. Variable surface area stent
US6676692B2 (en) * 2001-04-27 2004-01-13 Intek Technology L.L.C. Apparatus for delivering, repositioning and/or retrieving self-expanding stents
US7011675B2 (en) * 2001-04-30 2006-03-14 Boston Scientific Scimed, Inc. Endoscopic stent delivery system and method
US6660034B1 (en) 2001-04-30 2003-12-09 Advanced Cardiovascular Systems, Inc. Stent for increasing blood flow to ischemic tissues and a method of using the same
US6685745B2 (en) * 2001-05-15 2004-02-03 Scimed Life Systems, Inc. Delivering an agent to a patient's body
US6749628B1 (en) * 2001-05-17 2004-06-15 Advanced Cardiovascular Systems, Inc. Stent and catheter assembly and method for treating bifurcations
EP2796098A3 (en) * 2001-06-08 2015-01-07 Morris Innovative Research, Inc. Method and apparatus for sealing access
US6629994B2 (en) 2001-06-11 2003-10-07 Advanced Cardiovascular Systems, Inc. Intravascular stent
US6749629B1 (en) 2001-06-27 2004-06-15 Advanced Cardiovascular Systems, Inc. Stent pattern with figure-eights
US6676693B1 (en) * 2001-06-27 2004-01-13 Advanced Cardiovascular Systems, Inc. Apparatus and method for delivering a self-expanding stent
US6673154B1 (en) * 2001-06-28 2004-01-06 Advanced Cardiovascular Systems, Inc. Stent mounting device to coat a stent
US6761703B2 (en) * 2001-07-03 2004-07-13 Scimed Life Systems, Inc. Catheter incorporating a high column high column strength distal tip region
US6641611B2 (en) 2001-11-26 2003-11-04 Swaminathan Jayaraman Therapeutic coating for an intravascular implant
US6908480B2 (en) * 2001-08-29 2005-06-21 Swaminathan Jayaraman Structurally variable stents
US6656351B2 (en) 2001-08-31 2003-12-02 Advanced Cardiovascular Systems, Inc. Embolic protection devices one way porous membrane
US6805703B2 (en) 2001-09-18 2004-10-19 Scimed Life Systems, Inc. Protective membrane for reconfiguring a workpiece
US6790223B2 (en) * 2001-09-21 2004-09-14 Scimed Life Systems, Inc. Delivering a uretheral stent
US6753071B1 (en) 2001-09-27 2004-06-22 Advanced Cardiovascular Systems, Inc. Rate-reducing membrane for release of an agent
US6752825B2 (en) * 2001-10-02 2004-06-22 Scimed Life Systems, Inc Nested stent apparatus
US6693522B2 (en) * 2001-10-12 2004-02-17 Lear Corporation System and method for tire pressure monitoring including automatic tire location recognition
US6866669B2 (en) * 2001-10-12 2005-03-15 Cordis Corporation Locking handle deployment mechanism for medical device and method
EP1304092B1 (en) 2001-10-22 2007-12-05 Terumo Kabushiki Kaisha Stent and method of producing the same
US20030077310A1 (en) 2001-10-22 2003-04-24 Chandrashekhar Pathak Stent coatings containing HMG-CoA reductase inhibitors
US20030083734A1 (en) 2001-10-25 2003-05-01 Curative Ag Stent
US6746423B1 (en) * 2001-11-01 2004-06-08 Advanced Cardiovascular Systems, Inc. Catheter having improved rapid exchange junction
US7014654B2 (en) 2001-11-30 2006-03-21 Scimed Life Systems, Inc. Stent designed for the delivery of therapeutic substance or other agents
US6663880B1 (en) * 2001-11-30 2003-12-16 Advanced Cardiovascular Systems, Inc. Permeabilizing reagents to increase drug delivery and a method of local delivery
US20030114919A1 (en) 2001-12-10 2003-06-19 Mcquiston Jesse Polymeric stent with metallic rings
US6752826B2 (en) 2001-12-14 2004-06-22 Thoratec Corporation Layered stent-graft and methods of making the same
US6805707B1 (en) 2001-12-27 2004-10-19 Advanced Cardiovascular Systems, Inc. Stent with improved ring and link pattern
US7163553B2 (en) 2001-12-28 2007-01-16 Advanced Cardiovascular Systems, Inc. Intravascular stent and method of use
US7029493B2 (en) 2002-01-25 2006-04-18 Cordis Corporation Stent with enhanced crossability
US6989024B2 (en) * 2002-02-28 2006-01-24 Counter Clockwise, Inc. Guidewire loaded stent for delivery through a catheter
US6773448B2 (en) * 2002-03-08 2004-08-10 Ev3 Inc. Distal protection devices having controllable wire motion
US6911039B2 (en) 2002-04-23 2005-06-28 Medtronic Vascular, Inc. Integrated mechanical handle with quick slide mechanism
US6780182B2 (en) * 2002-05-23 2004-08-24 Adiana, Inc. Catheter placement detection system and operator interface
US6761731B2 (en) 2002-06-28 2004-07-13 Cordis Corporation Balloon-stent interaction to help reduce foreshortening
US6773447B2 (en) * 2002-07-02 2004-08-10 Sentient Engineering & Technology, Llc Balloon catheter and treatment apparatus
US20040006380A1 (en) * 2002-07-05 2004-01-08 Buck Jerrick C. Stent delivery system
US6802859B1 (en) 2002-07-12 2004-10-12 Endovascular Technologies, Inc. Endovascular stent-graft with flexible bifurcation
WO2004016199A1 (en) 2002-08-15 2004-02-26 Gmp Cardiac Care, Inc. Stent-graft with rails
US6818063B1 (en) 2002-09-24 2004-11-16 Advanced Cardiovascular Systems, Inc. Stent mandrel fixture and method for minimizing coating defects
US6702850B1 (en) * 2002-09-30 2004-03-09 Mediplex Corporation Korea Multi-coated drug-eluting stent for antithrombosis and antirestenosis
CA2499710A1 (en) 2002-09-30 2004-04-15 Board Of Regents The University Of Texas System Stent delivery system and method of use
US6673101B1 (en) * 2002-10-09 2004-01-06 Endovascular Technologies, Inc. Apparatus and method for deploying self-expanding stents
US20040093056A1 (en) 2002-10-26 2004-05-13 Johnson Lianw M. Medical appliance delivery apparatus and method of use
US6984244B2 (en) * 2003-03-27 2006-01-10 Endovascular Technologies, Inc. Delivery system for endoluminal implant

Also Published As

Publication number Publication date
JP4570957B2 (en) 2010-10-27
JP2006503671A (en) 2006-02-02
US7608099B2 (en) 2009-10-27
US20040093056A1 (en) 2004-05-13
US20100004732A1 (en) 2010-01-07
WO2004039242A2 (en) 2004-05-13
AU2003301732B2 (en) 2007-06-14
US20060200222A1 (en) 2006-09-07
WO2004039242A3 (en) 2004-08-12
EP1553903A4 (en) 2008-03-19
US8267987B2 (en) 2012-09-18
AU2003301732A1 (en) 2004-05-25
EP1553903A2 (en) 2005-07-20

Similar Documents

Publication Publication Date Title
US7608099B2 (en) Medical appliance delivery apparatus and method of use
US8298277B2 (en) Medical appliance optical delivery and deployment apparatus and method
US5645559A (en) Multiple layer stent
AU766325B2 (en) Stent delivery system for prevention of kinking, and method of loading and using same
US9095464B2 (en) Slotted pusher rod for flexible delivery system
US20070179587A1 (en) Apparatus and methods for deployment of custom-length prostheses
US20020183827A1 (en) Stent delivery device and method
CA2523715A1 (en) Bifurcated medical appliance delivery apparatus and method
JPH0759802A (en) Multicapsule intraluminal implant device
JP4758985B2 (en) Distal wire stop device

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued