CA2508323A1 - Method and apparatus for pretreatment of biological samples - Google Patents
Method and apparatus for pretreatment of biological samples Download PDFInfo
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- CA2508323A1 CA2508323A1 CA002508323A CA2508323A CA2508323A1 CA 2508323 A1 CA2508323 A1 CA 2508323A1 CA 002508323 A CA002508323 A CA 002508323A CA 2508323 A CA2508323 A CA 2508323A CA 2508323 A1 CA2508323 A1 CA 2508323A1
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- 238000000034 method Methods 0.000 title claims abstract description 59
- 239000012472 biological sample Substances 0.000 title claims abstract description 28
- 238000010186 staining Methods 0.000 claims abstract description 47
- 230000008569 process Effects 0.000 claims abstract description 26
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 24
- 238000012545 processing Methods 0.000 claims description 118
- 239000000523 sample Substances 0.000 claims description 58
- 239000012530 fluid Substances 0.000 claims description 42
- 238000012546 transfer Methods 0.000 claims description 29
- 239000007788 liquid Substances 0.000 claims description 20
- 238000010438 heat treatment Methods 0.000 claims description 17
- 238000011282 treatment Methods 0.000 claims description 17
- 239000002699 waste material Substances 0.000 claims description 13
- 230000000712 assembly Effects 0.000 claims description 8
- 238000000429 assembly Methods 0.000 claims description 8
- 238000002203 pretreatment Methods 0.000 claims description 6
- 230000004913 activation Effects 0.000 claims description 2
- 238000004064 recycling Methods 0.000 claims description 2
- 238000003860 storage Methods 0.000 claims description 2
- 239000000969 carrier Substances 0.000 abstract description 7
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- 238000004458 analytical method Methods 0.000 description 5
- 239000012188 paraffin wax Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 239000000872 buffer Substances 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 230000002055 immunohistochemical effect Effects 0.000 description 3
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
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- 230000003044 adaptive effect Effects 0.000 description 1
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- 230000003247 decreasing effect Effects 0.000 description 1
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- 238000002509 fluorescent in situ hybridization Methods 0.000 description 1
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- 238000004321 preservation Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
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Abstract
The present invention concerns a method and an apparatus for automatic staining at least one biological sample, such as a tissue, accommodated on a carrier, e.g. a microscope slide (7) by applying a predetermined amount of reagents in a sequence according to a staining protocol, wherein at least on e carrier is provided in a carrier rack assembly, wherein the carrier rack assembly comprises means for pretreatment of the biological sample on a carrier after the carrier is provided in the carrier rack assembly, said mea ns for pretreatment of biological samples includes a tank (101) which is provid ed in the carrier rack assembly (6), a carrier rack (61); and means for pivotin g the carriers (7) provided in the carrier rack (61) to a vertical position an d means for immersing the vertical carrier (7v) into the tank (101). By pivoti ng the carriers (7) from a horizontal to a vertical position, an automated meth od and apparatus for carrying out the pretreatment in the automated staining apparatus is provided. This pivoting of carriers (7) ensures an appropriate orientation of the carriers for both the pretreatment and the staining processes.
Description
l , METHOD AND APPARATUS FOR PRETREATMENT OF BIOLOGICAL SAMPLES
The present invention relates to a method and an apparatus for automatic staining at least one biological sample accommodated on a slide by applying a predetermined amount of reagents in a sequence according to a staining protocol, wherein at least one slide is provided in a slide rack asserribly.
This application relates to the field of sample processing systems and methods of processing biological samples. The present , invention may be directed to the automated processing, treatment, or even staining of samniec ~ a,-ranaP.~
microscope slides or similar plane, rectangular sample carriers, and in some embodiments, directed to the continuous or batch processing of samples and carriers, as well as washing elements of a sampling system. Embodiments may further relate to control systems for sample processing and data acquisition, data maintenance, and data retrieval for sample processing. Applications to which the present invention may especially relate include immunohistochemistry, in-situ hybridization, fluorescent in-situ hybridization, special staining, and microarrays, as well as potentially other chemical and biological applications.
Sample processing in immunohistochemical (IHC) applications and in other chemical and biological analyses may require one or a number of various processing sequences or protocols as part of an analysis of one or more samples. The sample processing sequences or protocols may be defined by the individual or organization requesting an analysis, such as a pathologist or histologist of a hospital, and may be further defined by the dictates of a particular analysis to be performed.
In preparation for sample analysis, a biological sample may be acquired by known sample acquisition techniques and may comprise, for example in IHC
applications, tissues generally or even in some applications one or a plurality of isolated cells, such as . in microarray samples, and may be presented on a a microscope slide.
Furthermore, the~~sample may be presented on the slide variously and potentially in some form of preservation. As one example, a sample such as a layer or slice .of skin P140 WO Ol -clean version Dato: 10-03-2005 AMENDED SHEET
The present invention relates to a method and an apparatus for automatic staining at least one biological sample accommodated on a slide by applying a predetermined amount of reagents in a sequence according to a staining protocol, wherein at least one slide is provided in a slide rack asserribly.
This application relates to the field of sample processing systems and methods of processing biological samples. The present , invention may be directed to the automated processing, treatment, or even staining of samniec ~ a,-ranaP.~
microscope slides or similar plane, rectangular sample carriers, and in some embodiments, directed to the continuous or batch processing of samples and carriers, as well as washing elements of a sampling system. Embodiments may further relate to control systems for sample processing and data acquisition, data maintenance, and data retrieval for sample processing. Applications to which the present invention may especially relate include immunohistochemistry, in-situ hybridization, fluorescent in-situ hybridization, special staining, and microarrays, as well as potentially other chemical and biological applications.
Sample processing in immunohistochemical (IHC) applications and in other chemical and biological analyses may require one or a number of various processing sequences or protocols as part of an analysis of one or more samples. The sample processing sequences or protocols may be defined by the individual or organization requesting an analysis, such as a pathologist or histologist of a hospital, and may be further defined by the dictates of a particular analysis to be performed.
In preparation for sample analysis, a biological sample may be acquired by known sample acquisition techniques and may comprise, for example in IHC
applications, tissues generally or even in some applications one or a plurality of isolated cells, such as . in microarray samples, and may be presented on a a microscope slide.
Furthermore, the~~sample may be presented on the slide variously and potentially in some form of preservation. As one example, a sample such as a layer or slice .of skin P140 WO Ol -clean version Dato: 10-03-2005 AMENDED SHEET
2 may be preserved in formaldehyde and presented on a slide with one or more paraffin or other chemical layers overlying the sample.
Immunologic applications, fox example, may require processing sequences or protocols that comprise steps such as deparaffinization, target retrieval, and staining, especially for in-situ hybridization (ISH) techniques. Previously, ,in some applications, these steps may have been performed manually, potentially creating a time-intensive protocol and necessitating personnel to be actively involved in the sample processing. Attempts have been made to automate sample processing to address the need for expedient sample processing and a less manually burdensome operation. However, such previous efforts may have not fully addressed the needs for an automated sample processing system. Previous efforts to automate sample processing may be deficient in several aspects that prevent more robust automated sample processing, such as: the lack of sufficient computer control and monitoring of sample processing; the lack of information sharing for processing protocol and processing status, especially for individual samples; the lack of diagnostic capabilities; and the lack of real-time or adaptive capabilities for multiple sample batch processing.
Past efforts at automated sample processing for samples presented on caxriers such as slides, such as US Patent No. 6,352,861 and US Patent No. 5,839,091, have not afforded the various advantages and other combinations of features as presented herein.
The biological samples, such as tissue samples, must be prepared before the staining can be performed. The tissue slides are 'subjected to a pretreatment process depending on the type of staining process is to be performed on the tissue.
This pretreatment could include a deparafmization or a target retrieval. The preparation of the tissues on the slides is often carried out manually in the laboratory before they are loaded into the automatic staining instrument. This pretreatment includes immersing the slide in a buffer or other types of processing liquid for a predetermined amount of time and temperature.
P140 WO 01 -clean version Dato: 10-03-2005 AMENDED SHEET
Immunologic applications, fox example, may require processing sequences or protocols that comprise steps such as deparaffinization, target retrieval, and staining, especially for in-situ hybridization (ISH) techniques. Previously, ,in some applications, these steps may have been performed manually, potentially creating a time-intensive protocol and necessitating personnel to be actively involved in the sample processing. Attempts have been made to automate sample processing to address the need for expedient sample processing and a less manually burdensome operation. However, such previous efforts may have not fully addressed the needs for an automated sample processing system. Previous efforts to automate sample processing may be deficient in several aspects that prevent more robust automated sample processing, such as: the lack of sufficient computer control and monitoring of sample processing; the lack of information sharing for processing protocol and processing status, especially for individual samples; the lack of diagnostic capabilities; and the lack of real-time or adaptive capabilities for multiple sample batch processing.
Past efforts at automated sample processing for samples presented on caxriers such as slides, such as US Patent No. 6,352,861 and US Patent No. 5,839,091, have not afforded the various advantages and other combinations of features as presented herein.
The biological samples, such as tissue samples, must be prepared before the staining can be performed. The tissue slides are 'subjected to a pretreatment process depending on the type of staining process is to be performed on the tissue.
This pretreatment could include a deparafmization or a target retrieval. The preparation of the tissues on the slides is often carried out manually in the laboratory before they are loaded into the automatic staining instrument. This pretreatment includes immersing the slide in a buffer or other types of processing liquid for a predetermined amount of time and temperature.
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3 However, this manual preparation is cumbersome and the pretreatment may be insufficient, since it is critical that the amount of time and the temperature of the liquid must be observed very precisely in order to achieve the correct pretreatment result.
~In the US Patent No. 5,39,091, an automated staining apparatus is disclosed wherein a plurality of biological samples accommodated on microscope slides may be processed. However this instrument does not provide a processing tank for pre-treatment of the slides.
On this background, it is an object of the invention to provide an automatic pretreatment of the biological samples on slides, in the automatic staining apparatus so that the entire processing of the biological samples may be performed in a single automatic apparatus.
, The invention consists of a method of treatment of at least one biological sample accommodated on a slide in an automated staining apparatus, said method comprising the steps of providing at least one slide carrying a biological sample in a predetermined slide location, said slide being provided in a~ substantially horizontal position in a slide holder (62);; characterised by pivoting said at least one slide to a substantially,vertical position; immersing said substantially vertically oriented slide into a processing tank for a predetermined processing time and after the predetermined processing time removing the vertically oriented slide (7v) from the processing tank and pivoting said slide (7v) to a substantially horizontal position.
Preferably, the slide location is a slide rack, wherein a plurality of slides may be provided in a slide holder, wherein the slides are individually pivotable.
The object is also achieved by an apparatus for automatic staining at least one biological sample accommodated on a slide by applying a predetermined amount of reagents in a sequence according to a staining protocol, wherein at least one slide is provided in a substantially horizontal position in a slide holder (62) in a slide rack, wherein the slide rack is arranged in a slide rack assembly comprising means for P140 WO Ol-clean version Dato: 10-03-2005 AMENDED SHEET
12-03-2005 CA 02508323 2005-06-02 DK0300$77
~In the US Patent No. 5,39,091, an automated staining apparatus is disclosed wherein a plurality of biological samples accommodated on microscope slides may be processed. However this instrument does not provide a processing tank for pre-treatment of the slides.
On this background, it is an object of the invention to provide an automatic pretreatment of the biological samples on slides, in the automatic staining apparatus so that the entire processing of the biological samples may be performed in a single automatic apparatus.
, The invention consists of a method of treatment of at least one biological sample accommodated on a slide in an automated staining apparatus, said method comprising the steps of providing at least one slide carrying a biological sample in a predetermined slide location, said slide being provided in a~ substantially horizontal position in a slide holder (62);; characterised by pivoting said at least one slide to a substantially,vertical position; immersing said substantially vertically oriented slide into a processing tank for a predetermined processing time and after the predetermined processing time removing the vertically oriented slide (7v) from the processing tank and pivoting said slide (7v) to a substantially horizontal position.
Preferably, the slide location is a slide rack, wherein a plurality of slides may be provided in a slide holder, wherein the slides are individually pivotable.
The object is also achieved by an apparatus for automatic staining at least one biological sample accommodated on a slide by applying a predetermined amount of reagents in a sequence according to a staining protocol, wherein at least one slide is provided in a substantially horizontal position in a slide holder (62) in a slide rack, wherein the slide rack is arranged in a slide rack assembly comprising means for P140 WO Ol-clean version Dato: 10-03-2005 AMENDED SHEET
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4 pretreatment of the biological sample on a slide after the slide is provided in the slide rack assembly, said means for pretreatment of biological samples including a processing tank which is provided in the slide rack assembly;; and means for pivoting the slides provided in the slide holder to a vertical position, means for immersing the vertical slide into the processing tank, and means for pivoting the vertical slides (7v) to the substantially horizontal position.
By pivoting the slides from a horizontal to a vertical position, an automated method and apparatus for carrying out the pretreatment in the automated staining apparatus is provided. This pivoting of slides ensures an appropriate orientation of fhe slides for both the pretreatment and the staining processes.
By the present invention, the preparation of the biological samples on the slides is integrated in the automatic staining apparatus, so that a tissue sample once it is 1 S accommodated on a slide can be loaded into a staining apparatus wherein both the pretreatment and the staining protocols may be performed automatically in the apparatus.
Preferably, a selected processing liquid is supplied from at least one supply'tank into a processing tank. The steps of filling and draining the processing tank are controlled by the control system of the apparatus, which ensures that the slides are subjected to the appropriate pretreatment steps according to information concerning this in the staining protocol.
Preferably, the liquid is transferred from a supply tank to a transfer tank and onwards to a processing tank. Accordingly, the apparatus preferably comprises pneumatic means for transferring processing liquid from a supply tank to a transfer tank and from the transfer tank to the processing tank and draining liquid from the processing tank to the transfer tank and from said transfer tank to a waste collection tank. An advantage achieved by transferring the liquids. by a pneumatic system is that the at least one transfer tank, the supply tank and the waste tank may be. positioned outside the apparatus, hereby allowing for an increased capacity as there are no dimensional P140 WO 01 -clean version Dato: 10-03-2005 AMENDED SHEET
constrains on the tank sizes. Furthermore, by this embodiment of the invention it is possible to subject the immersed slide to a series of fluids which are sequentially filled and drained from the processing tank, since the system may easily be adapted to contain several supply tanks containing different liquids and similarly also several
By pivoting the slides from a horizontal to a vertical position, an automated method and apparatus for carrying out the pretreatment in the automated staining apparatus is provided. This pivoting of slides ensures an appropriate orientation of fhe slides for both the pretreatment and the staining processes.
By the present invention, the preparation of the biological samples on the slides is integrated in the automatic staining apparatus, so that a tissue sample once it is 1 S accommodated on a slide can be loaded into a staining apparatus wherein both the pretreatment and the staining protocols may be performed automatically in the apparatus.
Preferably, a selected processing liquid is supplied from at least one supply'tank into a processing tank. The steps of filling and draining the processing tank are controlled by the control system of the apparatus, which ensures that the slides are subjected to the appropriate pretreatment steps according to information concerning this in the staining protocol.
Preferably, the liquid is transferred from a supply tank to a transfer tank and onwards to a processing tank. Accordingly, the apparatus preferably comprises pneumatic means for transferring processing liquid from a supply tank to a transfer tank and from the transfer tank to the processing tank and draining liquid from the processing tank to the transfer tank and from said transfer tank to a waste collection tank. An advantage achieved by transferring the liquids. by a pneumatic system is that the at least one transfer tank, the supply tank and the waste tank may be. positioned outside the apparatus, hereby allowing for an increased capacity as there are no dimensional P140 WO 01 -clean version Dato: 10-03-2005 AMENDED SHEET
constrains on the tank sizes. Furthermore, by this embodiment of the invention it is possible to subject the immersed slide to a series of fluids which are sequentially filled and drained from the processing tank, since the system may easily be adapted to contain several supply tanks containing different liquids and similarly also several
5 waste tanks so that it is possible to sort the waste.
Preferably, said processing tank is provided 'with a heating member for heating the processing liquid contained in the tank, and the heating member may advantageously be capable of heating the tank content to an elevated temperature of at least 60, more preferably at least 95°C, and even more preferably at least 115°C. Hereby, the temperature of the fluid in the tank may be heated up to 120°C or even as high as 150°C and kept at this temperature for between 10 to 20 minutes without any sign of boiling. In an embodiment, the heating member is adapted to heat the fluid to a temperature of 95°C for 40 minutes or more for performing a target retrieval process.
According to an embodiment of the invention, the at least one vertical slide is immersed into the processing tank by lowering the slide holder and immersing the slide into the tank after at least one slide is pivoted to a vertical position. Hereby, a compact tank arrangement and slide holder lay out is achieved.
The method of treatment of tissue could be a pretreatment of the tissue sample.
However, by the invention it is realised that other types of treatment may be performed on the tissue sample on the slide in a vertical position, such as rinsing the slides. Other processes that may be performed by an apparatus according to the invention include deparaffinization or target retrieval processes of the tissue sample.
According to the invention, the processing tank is an elongated container having an upper opening slot allowing the vertically oriented slides to be inserted into the tank for treatment. Hereby; the volume of the tank and thereby the amount of processing fluid needed is minimized.
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Preferably, said processing tank is provided 'with a heating member for heating the processing liquid contained in the tank, and the heating member may advantageously be capable of heating the tank content to an elevated temperature of at least 60, more preferably at least 95°C, and even more preferably at least 115°C. Hereby, the temperature of the fluid in the tank may be heated up to 120°C or even as high as 150°C and kept at this temperature for between 10 to 20 minutes without any sign of boiling. In an embodiment, the heating member is adapted to heat the fluid to a temperature of 95°C for 40 minutes or more for performing a target retrieval process.
According to an embodiment of the invention, the at least one vertical slide is immersed into the processing tank by lowering the slide holder and immersing the slide into the tank after at least one slide is pivoted to a vertical position. Hereby, a compact tank arrangement and slide holder lay out is achieved.
The method of treatment of tissue could be a pretreatment of the tissue sample.
However, by the invention it is realised that other types of treatment may be performed on the tissue sample on the slide in a vertical position, such as rinsing the slides. Other processes that may be performed by an apparatus according to the invention include deparaffinization or target retrieval processes of the tissue sample.
According to the invention, the processing tank is an elongated container having an upper opening slot allowing the vertically oriented slides to be inserted into the tank for treatment. Hereby; the volume of the tank and thereby the amount of processing fluid needed is minimized.
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6 Preferably, the apparatus includes means for recycling the drained liquid for re-use in a later pre-treatment process of slides. Hereby, the amount of fluids used for the operation of the apparatus, i.e. the pretreatment and the rinsing of the tissue slides, may be minimized resulting in an easier waste handling and a reduction in costs.
In the preferred embodiment of the invention, the slide rack assembly is provided in a drawer assembly, wherein the rack may be retracted from the apparatus for loading and unloading of slides. The drawer assembly cooperates with a processing tank in the drawer receiving means of the apparatus, said processing tank being capable of simultaneous processing of a plurality of slides accommodated in a plurality of slide holders in the slide rack assembly. The drawer assembly provides the apparatus with a great flexibility in use, as slides may be loaded or unloaded from one drawer while the slides in the other drawers may be processed independent thereof.
Furthermore, the use of. drawers makes it easy to operate the automatic staining apparatus.
The processing tanks for each of the drawers may preferably be connected to common supply and waste tanks which advantageously may be arranged outside the apparatus.
The invention is described with reference to a preferred embodiment with reference to the drawings, in which:
Fig. 1 is a schematic perspective view of a staining apparatus according to the preferred embodiment of the invention;
Fig. 2 is a top view of the work area in the staining apparatus shown in fig.
1;
Fig. 3 is a schematic front view of a drawer assembly including a slide rack and a processing tank in an apparatus according to the invention;
Fig. 4 is a perspective view of a drawer assembly in a closed position;
Fig. 5 is the drawer assembly of fig. 4 in an open position;
Fig. 6 is a perspective top view of a slide rack according to a preferred embodiment of the invention;
Fig. 7 is a detailed view of the slide rack holder and the processing tank arranged in a drawer assembly;
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In the preferred embodiment of the invention, the slide rack assembly is provided in a drawer assembly, wherein the rack may be retracted from the apparatus for loading and unloading of slides. The drawer assembly cooperates with a processing tank in the drawer receiving means of the apparatus, said processing tank being capable of simultaneous processing of a plurality of slides accommodated in a plurality of slide holders in the slide rack assembly. The drawer assembly provides the apparatus with a great flexibility in use, as slides may be loaded or unloaded from one drawer while the slides in the other drawers may be processed independent thereof.
Furthermore, the use of. drawers makes it easy to operate the automatic staining apparatus.
The processing tanks for each of the drawers may preferably be connected to common supply and waste tanks which advantageously may be arranged outside the apparatus.
The invention is described with reference to a preferred embodiment with reference to the drawings, in which:
Fig. 1 is a schematic perspective view of a staining apparatus according to the preferred embodiment of the invention;
Fig. 2 is a top view of the work area in the staining apparatus shown in fig.
1;
Fig. 3 is a schematic front view of a drawer assembly including a slide rack and a processing tank in an apparatus according to the invention;
Fig. 4 is a perspective view of a drawer assembly in a closed position;
Fig. 5 is the drawer assembly of fig. 4 in an open position;
Fig. 6 is a perspective top view of a slide rack according to a preferred embodiment of the invention;
Fig. 7 is a detailed view of the slide rack holder and the processing tank arranged in a drawer assembly;
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7 Fig. S is a perspective view of a processing tank according to the preferred embodiment of the invention;
Fig. 9 . is a front view of the processing tank of fig. ~; and Fig. 10 is a fluidic diagram of the handling of processing liquid for the processing tank.
Figure 1 shows one schematic embodiment of a sample processing system 101 in accordance with the present invention.. Cabinet sections 4 form outer portions of the system and serve to address general structural considerations of the system (a top cabinet section is not shown in Figure 1). The sample processing system may comprise a plurality of drawers 6 used for the handling and processing of samples and microscope slides. Other sample carriers may be accommodated consistent with the present invention. Each drawer may be configured to accommodate sample carrier retainment assemblies, such as slide retainment assemblies, earner racks, modules, or magazines.
One embodiment of a sample carnet retainment assembly may comprise a slide retainment assembly 6 as shown in Figure 7. The slide retainment assembly may comprise a slide rack, module, or magazines. Slide retainment assembly 6 is configured to accommodate a plurality of slides in at least one configuration in corresponding sample carrier retention devices. The sample carrier retainment assemblies, are utilized in the processing of samples as further described below. It should be further noted that the sample carrier retainment assembly can be removably configured with the drawers, and may be stackable or nested within other retainment assemblies.
In preferred embodiments, slides are configurable in both vertical and horizontal positions as required for the pretreatment and staining process, as shown in Figures 3 and 6. This allows for the automation of the pretreatment and staining of slides in various manners, including pretreatment and staining as accepted in conventional manual laboratory methods. The slides are initially loaded into the carrier retention assemblies, such as slide racks, and drawers in the horizontal P140 WO Ol -clean version Dato: 10-03-2005 AMENDED SHEET
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Fig. 9 . is a front view of the processing tank of fig. ~; and Fig. 10 is a fluidic diagram of the handling of processing liquid for the processing tank.
Figure 1 shows one schematic embodiment of a sample processing system 101 in accordance with the present invention.. Cabinet sections 4 form outer portions of the system and serve to address general structural considerations of the system (a top cabinet section is not shown in Figure 1). The sample processing system may comprise a plurality of drawers 6 used for the handling and processing of samples and microscope slides. Other sample carriers may be accommodated consistent with the present invention. Each drawer may be configured to accommodate sample carrier retainment assemblies, such as slide retainment assemblies, earner racks, modules, or magazines.
One embodiment of a sample carnet retainment assembly may comprise a slide retainment assembly 6 as shown in Figure 7. The slide retainment assembly may comprise a slide rack, module, or magazines. Slide retainment assembly 6 is configured to accommodate a plurality of slides in at least one configuration in corresponding sample carrier retention devices. The sample carrier retainment assemblies, are utilized in the processing of samples as further described below. It should be further noted that the sample carrier retainment assembly can be removably configured with the drawers, and may be stackable or nested within other retainment assemblies.
In preferred embodiments, slides are configurable in both vertical and horizontal positions as required for the pretreatment and staining process, as shown in Figures 3 and 6. This allows for the automation of the pretreatment and staining of slides in various manners, including pretreatment and staining as accepted in conventional manual laboratory methods. The slides are initially loaded into the carrier retention assemblies, such as slide racks, and drawers in the horizontal P140 WO Ol -clean version Dato: 10-03-2005 AMENDED SHEET
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8 position. The slides may be horizontally supported by adjustable slide supports (shown in Figure 7). If pretreatment is required, such as deparaffinization, the system rotates the slide into the vertical position and lowers these samples into a dip processing tank, further described below, filled with the required fluids. In some embodiments, the slide rack is lowered to affect lowering of the slides (see Figure 3 and Figure 7). To perform the staining process on the slides, as described below, the System rotates the slide.to the horizontal position and a syringe or probe applies fluid to the sample. Each slide can be rotated independently allowing for the independent processing of different samples with different requirements.
The sample processing system may automate processing steps of samples such as histological tissue sections or cell preparations presented on slides by pre-treatment processing, such as deparaffinization. The System provides onboard pretreatment of the slides. Examples of two types of pretreatment that axe usually performed are - but not limited to - deparaffmization and target retrieval. In some embodiments, these processes must be performed with the slides in a vertical orientation, immersed in processing tanks of various fluids. Deparaffinization involves immersing the slides sequentially in a series of fluids for short periods of time (potentially for about 5 or IO minutes). The process is intended to first remove from the sample the paraffin in which it was mounted or otherwise presented, remove the paraffin solvent, and then slowly rehydrate the sample. Target retrieval, and in some embodiments epitope unmasking, involves immersing the slides in a processing tank of heated buffer, and in some embodiments, immersing for about minutes, and then allowing the slides to cool for about 20 minutes.
Temperature in preferred embodiments is maintained at about 95 °C. In target retrieval, a maxker or other identifier is used to mark a sample portion of interest, such as a cell or structure thereof.
The system automates, and in some embodiments mimics or otherwise corresponds to the procedure and physical att>~i~butes of the supplies used manually to perform these same pre-treatment processes. Accordingly, a processing tank 101 may be provided (as best shown in Figures 3, 7 and 8). In some embodiments, P140 WO 01 -clean version Dato: 10-03-2005 AMENDED SHEET
The sample processing system may automate processing steps of samples such as histological tissue sections or cell preparations presented on slides by pre-treatment processing, such as deparaffinization. The System provides onboard pretreatment of the slides. Examples of two types of pretreatment that axe usually performed are - but not limited to - deparaffmization and target retrieval. In some embodiments, these processes must be performed with the slides in a vertical orientation, immersed in processing tanks of various fluids. Deparaffinization involves immersing the slides sequentially in a series of fluids for short periods of time (potentially for about 5 or IO minutes). The process is intended to first remove from the sample the paraffin in which it was mounted or otherwise presented, remove the paraffin solvent, and then slowly rehydrate the sample. Target retrieval, and in some embodiments epitope unmasking, involves immersing the slides in a processing tank of heated buffer, and in some embodiments, immersing for about minutes, and then allowing the slides to cool for about 20 minutes.
Temperature in preferred embodiments is maintained at about 95 °C. In target retrieval, a maxker or other identifier is used to mark a sample portion of interest, such as a cell or structure thereof.
The system automates, and in some embodiments mimics or otherwise corresponds to the procedure and physical att>~i~butes of the supplies used manually to perform these same pre-treatment processes. Accordingly, a processing tank 101 may be provided (as best shown in Figures 3, 7 and 8). In some embodiments, P140 WO 01 -clean version Dato: 10-03-2005 AMENDED SHEET
9 components of each processing tank 101, as shown in Figures 4 and 5, are configured within a drawer 100. In some preferred embodiments, the fluids volume needed to perform pre-treatment processes are maintained but instead of the slide orientation with each other being face-to-face, as in conventional systems, they are side-to-side, although other slide configurations are not disclaimed. The processing tanks provide even distribution of fluids across the face of the slide.
In some embodiments, the processing tanks have the ability to heat the slides.
This heat is applied evenly across the face of each individual slide by a thermal device.
The precision and physical application of the heat can result in standardization and repeatability of process steps. Filling and heating tasks are preformed by a computer controlled scheduler, as further described below. Fluid volume may be adjusted to account for the presenceor absence of any number of slides.
A preferred embodiment of a staining apparatus 1 according to the invention is shown in figures 1 and 2. The staining apparatus 1 comprises a rectangular frame 4 surrounding a reagent station 2 comprising an array of reagent bottle compartments wherein each compartment a reagent vial 3 is placed, and a first and second slide sections 5 wherein a number of separate rack assemblies b is placed, and where each rack assembly 6 accommodates a number of microscope slides 7 mounted side by side in the rack assembly 6. In the embodiment shown, each rack may hold up to slides, but the rack may be designed to hold any suitable number of slides.
With eight racks arranged side by side, the shown embodiments may hold up to 64 slides 7 each having a sample, e.g. a tissue mounted on the upper side of the slide, so that reagent may be applied from above to the sample on each slide.
A robot arm 20 for moving a probe 10 in X and 'Y (as well as Z) direction as indicated by the arrows X and Y is arranged above the frame 4 of the staining apparatus. The robot arm 20 may therefore position the probe 10 above all reagent vials 3 as well as above all the microscope slides 7, and may further operate the probe 10 to aspirate portions of reagent contained in any of the vials 3, to transfer the portion of reagent and apply it to~ any of the slides 7 in order to provide a selected P140 WO Oi -clean version I7ato: 10-03-2005 AMENDED SHEET
~12-03-2005 CA 02508323 2005-06-02 DK0300877 staining or treatment of the sample on each slide 7. By use' of suitable control means e.g. a computer (not shown) having the appropriate software and input data for the purpose, this staining apparatus 1 is able to automatically staining or treating samples requiring different staining or treatment reagents and processes.
S
As shown in fig. 1, the probe 10 is accommodated in a robotic head 22 and is manipulated by the robot arm 20. The probe 10 is raised to an upper position (in a Z
direction) where it is clear of the vials 3 underneath the probe 10, but the robot comprises means in the robotic head 22 for lowering the probe 10 in order to dip the
In some embodiments, the processing tanks have the ability to heat the slides.
This heat is applied evenly across the face of each individual slide by a thermal device.
The precision and physical application of the heat can result in standardization and repeatability of process steps. Filling and heating tasks are preformed by a computer controlled scheduler, as further described below. Fluid volume may be adjusted to account for the presenceor absence of any number of slides.
A preferred embodiment of a staining apparatus 1 according to the invention is shown in figures 1 and 2. The staining apparatus 1 comprises a rectangular frame 4 surrounding a reagent station 2 comprising an array of reagent bottle compartments wherein each compartment a reagent vial 3 is placed, and a first and second slide sections 5 wherein a number of separate rack assemblies b is placed, and where each rack assembly 6 accommodates a number of microscope slides 7 mounted side by side in the rack assembly 6. In the embodiment shown, each rack may hold up to slides, but the rack may be designed to hold any suitable number of slides.
With eight racks arranged side by side, the shown embodiments may hold up to 64 slides 7 each having a sample, e.g. a tissue mounted on the upper side of the slide, so that reagent may be applied from above to the sample on each slide.
A robot arm 20 for moving a probe 10 in X and 'Y (as well as Z) direction as indicated by the arrows X and Y is arranged above the frame 4 of the staining apparatus. The robot arm 20 may therefore position the probe 10 above all reagent vials 3 as well as above all the microscope slides 7, and may further operate the probe 10 to aspirate portions of reagent contained in any of the vials 3, to transfer the portion of reagent and apply it to~ any of the slides 7 in order to provide a selected P140 WO Oi -clean version I7ato: 10-03-2005 AMENDED SHEET
~12-03-2005 CA 02508323 2005-06-02 DK0300877 staining or treatment of the sample on each slide 7. By use' of suitable control means e.g. a computer (not shown) having the appropriate software and input data for the purpose, this staining apparatus 1 is able to automatically staining or treating samples requiring different staining or treatment reagents and processes.
S
As shown in fig. 1, the probe 10 is accommodated in a robotic head 22 and is manipulated by the robot arm 20. The probe 10 is raised to an upper position (in a Z
direction) where it is clear of the vials 3 underneath the probe 10, but the robot comprises means in the robotic head 22 for lowering the probe 10 in order to dip the
10 probe tip into the content of a selected reagent vial 3 and to aspirate a selected amount of reagent for the selected staining or treatment process. The robotic head 22 is also provided with a CCD camera 25 pointing downwards. The camera is utilised to determine status information of the slides and the reagent bottles and other features of the apparatus in the work area, for example reading a code provided on a reagent container to determine the reagent type and the reagent location within the system. The camera may also determine status of the tissue sample slides, for example the location of a particular slide, informational indicia, such as a code, that indicate information about the tissue sample presented on the slide or the processing protocol to be performed.
The staining apparatus 1 of the present embodiment further comprises a probe washing station 8 and a reagent mixer 9, and the robot arm 20 is furthermore arranged to transfer the probe to the washing station 8 as well as to the reagent mixer 9.
The slides 7 in the slide rack are loaded and unloaded in a horizontal position when the slide rack is in an upper position, as shown in fig. 3. The slide rack is arranged in a slide elevator 63 and the slide holder 62 is adapted to pivot the slide 7 between a horizontal position and a vertical position 7v, when the slide rack 6 is in its upper position. The slide rack and the slide rack elevator 63 is arranged as a moving part 100a of a drawer assembly 100. In a corresponding stationary part 100b of the drawer assembly 100, a processing tank 101 is provided.
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The staining apparatus 1 of the present embodiment further comprises a probe washing station 8 and a reagent mixer 9, and the robot arm 20 is furthermore arranged to transfer the probe to the washing station 8 as well as to the reagent mixer 9.
The slides 7 in the slide rack are loaded and unloaded in a horizontal position when the slide rack is in an upper position, as shown in fig. 3. The slide rack is arranged in a slide elevator 63 and the slide holder 62 is adapted to pivot the slide 7 between a horizontal position and a vertical position 7v, when the slide rack 6 is in its upper position. The slide rack and the slide rack elevator 63 is arranged as a moving part 100a of a drawer assembly 100. In a corresponding stationary part 100b of the drawer assembly 100, a processing tank 101 is provided.
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11 The apparatus preferably comprises eight drawer assemblies, as shown in figure 1.
However, it is realised that any other number may also be provided depending on the design preferences. Each drawer assembly 100 includes a drawer slide, a slide rack elevator 63, a slide rack assembly 6 including slide temperature control members 64, a processing tank 101, a drip tray 65 for collecting staining fluids and control means including indicators for various user information and process surveillance purposes.
The slide rack 61 is shown in fig. 6. The slide rack assembly 6 includes a slide rack 61 preferably with a capacity of eight slides 7 in individual slide receiving compartments 68, as shown in fig. 6. In connection with each compartment 68, a slide holder 62 is provided. The slide holders 62 include pivoting means including slide clips 69 which are pivotable between a horizontal slide position and a vertical slide position and activation means 67. The slides 7, 7v are individually pivotable in their slide holders 62, as the slide holder clips 69 may be pivoted by a pushing of a nesting tab 67, of which two are provided, one for pivoting from a horizontal to a vertical position and one for returning the slide from a vertical to a horizontal position.
The slide rack is in an ugper position when the drawer 100 is loaded with one or more slides 7 and also during the staining process. After the slides 7 have been loaded, the slides 7 may be pivoted to a vertical position 7v and then the slide rack 61 is lowered by the slide elevator 63, such that the vertically disposed slides 7v are immersed into the underlying processing tank 101. The drawer assembly is also shown in the figures 4, 5 and 7. The slide elevator 63 may be adapted to agitate the slides 7v while they are immersed in the tank fluid.
The processing tank 101 is filled with a predetermined amount of a processing fluid from a transfer tank 110 (see fig. 10). The relevant processing fluid has prior to that been transferred from a supply tank 111 to the transfer tank 110 via pneumatic pressure means. Using a transfer tank 110, and controlling the fluid transfer by a pneumatic system, including a vacuum pump I13, the pumping may be carried out P140 WO 01 -clean version Dato: 10-03-2005 AMENDED SHEET
However, it is realised that any other number may also be provided depending on the design preferences. Each drawer assembly 100 includes a drawer slide, a slide rack elevator 63, a slide rack assembly 6 including slide temperature control members 64, a processing tank 101, a drip tray 65 for collecting staining fluids and control means including indicators for various user information and process surveillance purposes.
The slide rack 61 is shown in fig. 6. The slide rack assembly 6 includes a slide rack 61 preferably with a capacity of eight slides 7 in individual slide receiving compartments 68, as shown in fig. 6. In connection with each compartment 68, a slide holder 62 is provided. The slide holders 62 include pivoting means including slide clips 69 which are pivotable between a horizontal slide position and a vertical slide position and activation means 67. The slides 7, 7v are individually pivotable in their slide holders 62, as the slide holder clips 69 may be pivoted by a pushing of a nesting tab 67, of which two are provided, one for pivoting from a horizontal to a vertical position and one for returning the slide from a vertical to a horizontal position.
The slide rack is in an ugper position when the drawer 100 is loaded with one or more slides 7 and also during the staining process. After the slides 7 have been loaded, the slides 7 may be pivoted to a vertical position 7v and then the slide rack 61 is lowered by the slide elevator 63, such that the vertically disposed slides 7v are immersed into the underlying processing tank 101. The drawer assembly is also shown in the figures 4, 5 and 7. The slide elevator 63 may be adapted to agitate the slides 7v while they are immersed in the tank fluid.
The processing tank 101 is filled with a predetermined amount of a processing fluid from a transfer tank 110 (see fig. 10). The relevant processing fluid has prior to that been transferred from a supply tank 111 to the transfer tank 110 via pneumatic pressure means. Using a transfer tank 110, and controlling the fluid transfer by a pneumatic system, including a vacuum pump I13, the pumping may be carried out P140 WO 01 -clean version Dato: 10-03-2005 AMENDED SHEET
12-03-2005 CA 02508323 2005-06-02 DK0300877 without fluids coming into contact with pumping components. This is advantageous since the risk of residues of fluids in the components is hereby minimized.
A total of eight drawers are preferably provided. Accordingly, this means that eight processing tanks are also provided in the apparatus. Each processing tank 101 accommodates up to eight immersed slides 7v at the time. A primary function of the processing tank is to heat the fluid in the tank up from ambient temperature to a predetermined temperature, in a certain amount of time, e.g. 15 minutes and maintain the predetermined temperature, e.g. up to about 120°C without any sign of boiling , for a pretreatment processing time, e.g. 10 to 20 minutes after the slides have been lowered into the processing tank. Typically the preferred temperature is in the interval from about 40°C to about 120°C, as determined by the requested treatment.
Very often the preferred temperature is in the interval from 80°C to 100°C, and more preferable from 95°C to 98°C. For some special treatments the preferred interval can be from 110°C to 130°C and even up to about 150°C.
After this process time is passed, the heat is turned off and the slides 7v are removed by raising the slide rack 61 and thereby lifting the vertical slides 7v out of the processing tank 101. The tank 101 may be used for deparaffinization, re-hydration as well as heat induced target retrieval. These processes are performed onboard the apparatus with the slides in a vertical orientation, immersed in individual tanks that can be filled with and emptied of various required reagents. For the target retrieval process, the fluid level in the tank may raise onto the label on the slide.
The heating member may be adapted to heat up and maintain a temperature of approx.
95°C for a period of up to 40 to 60 minutes. The pretreatment process tamed out in the tank, may involve immersing the slides in a series of fluids for short periods of time, e.g. 5 to 10 minutes. The process of depaxaffinization is intended to first remove from the tissue sample the paraffin in which it was mounted, then remove the paraffin solvent, and then through a series of reagents progressively re-hydrate the sample.
As shown in e.g. figures 8 and 9,, the processing tank 101 is elongated with an opening slot 102 through which the slides 7v may be inserted. This -results in a P140 WO01 -clean version natn: 10-03-2005 AMENDED SHEET
'12-03-2005 CA 02508323 2005-06-02 D
A total of eight drawers are preferably provided. Accordingly, this means that eight processing tanks are also provided in the apparatus. Each processing tank 101 accommodates up to eight immersed slides 7v at the time. A primary function of the processing tank is to heat the fluid in the tank up from ambient temperature to a predetermined temperature, in a certain amount of time, e.g. 15 minutes and maintain the predetermined temperature, e.g. up to about 120°C without any sign of boiling , for a pretreatment processing time, e.g. 10 to 20 minutes after the slides have been lowered into the processing tank. Typically the preferred temperature is in the interval from about 40°C to about 120°C, as determined by the requested treatment.
Very often the preferred temperature is in the interval from 80°C to 100°C, and more preferable from 95°C to 98°C. For some special treatments the preferred interval can be from 110°C to 130°C and even up to about 150°C.
After this process time is passed, the heat is turned off and the slides 7v are removed by raising the slide rack 61 and thereby lifting the vertical slides 7v out of the processing tank 101. The tank 101 may be used for deparaffinization, re-hydration as well as heat induced target retrieval. These processes are performed onboard the apparatus with the slides in a vertical orientation, immersed in individual tanks that can be filled with and emptied of various required reagents. For the target retrieval process, the fluid level in the tank may raise onto the label on the slide.
The heating member may be adapted to heat up and maintain a temperature of approx.
95°C for a period of up to 40 to 60 minutes. The pretreatment process tamed out in the tank, may involve immersing the slides in a series of fluids for short periods of time, e.g. 5 to 10 minutes. The process of depaxaffinization is intended to first remove from the tissue sample the paraffin in which it was mounted, then remove the paraffin solvent, and then through a series of reagents progressively re-hydrate the sample.
As shown in e.g. figures 8 and 9,, the processing tank 101 is elongated with an opening slot 102 through which the slides 7v may be inserted. This -results in a P140 WO01 -clean version natn: 10-03-2005 AMENDED SHEET
'12-03-2005 CA 02508323 2005-06-02 D
13 relative small tank volume, which in turn allows for relatively rapid heating of the fluid in the tank andlor relatively low power consumption for heating up and maintaining the temperature of the fluid in the tank. The tank 101 is filled and drained via a fluid connection tube 103 and the heating member 104 is preferably located in the lower section of the tank. The tank 101 is moreover provided with insulating sidewall members vn both sides to accelerate the heating thereby decreasing the heating times. The tank 101 is also provided with sensor means (not shown) for registering the fluid level in the tank and a sensor for registering the temperature of the fluid, and feeding these . data to the control system of the apparatus.
The pretreatment fluids or reagents may be stored in a number of individual containers, where some containers store fluids that are dedicated for deparaffinization, some for target retrieval and containers with 100% alcohol, distilled water and buffers. The containers are advantageously provided with different volumes corresponding to the required amounts of the specific fluids for the performance of the pretreatment processes on the apparatus.
The fluid transfer between the supply containers 111 and the processing tanks are via a transfer tank 110, as shown in fig. 10. The fluid transfer is accomplished through positive and negative air pressure applied to the transfer tank 110.
Preferably two separate, dedicated transfer tanks (not shown) are provided, one for aqueous solutions and a second for organic solutions. Similarly, for emptying the processing tanks, the waste fluid is transferred via the transfer tank I 10 to the waste containers 112. Preferably dedicated waste tanks are provided, e. g. one for hazardous waste fluids and one for non-hazardous waste fluids.
Fluids may be transferred in both directions between any container and any tank.
The operational sequence of the fluid transfers is determined by the control system of the apparatus. The deparaffinization reagents may be. reused and periodically cycled from clean to dirty. Used dirty deparaffinization fluids and tank rinse fluids may be discarded by the user or by the control system as hazardous waste. Target retrieval PI40 WO01 -clean version Dato: i0-03-2005 AMENDED SHEET
The pretreatment fluids or reagents may be stored in a number of individual containers, where some containers store fluids that are dedicated for deparaffinization, some for target retrieval and containers with 100% alcohol, distilled water and buffers. The containers are advantageously provided with different volumes corresponding to the required amounts of the specific fluids for the performance of the pretreatment processes on the apparatus.
The fluid transfer between the supply containers 111 and the processing tanks are via a transfer tank 110, as shown in fig. 10. The fluid transfer is accomplished through positive and negative air pressure applied to the transfer tank 110.
Preferably two separate, dedicated transfer tanks (not shown) are provided, one for aqueous solutions and a second for organic solutions. Similarly, for emptying the processing tanks, the waste fluid is transferred via the transfer tank I 10 to the waste containers 112. Preferably dedicated waste tanks are provided, e. g. one for hazardous waste fluids and one for non-hazardous waste fluids.
Fluids may be transferred in both directions between any container and any tank.
The operational sequence of the fluid transfers is determined by the control system of the apparatus. The deparaffinization reagents may be. reused and periodically cycled from clean to dirty. Used dirty deparaffinization fluids and tank rinse fluids may be discarded by the user or by the control system as hazardous waste. Target retrieval PI40 WO01 -clean version Dato: i0-03-2005 AMENDED SHEET
14 buffer and water are labelled "single use" fluids in the control system and transferred to waste after use.
Preferably, the method according to the invention may include temporary storage of at least one biological sample on a slide in an appropriate liquid in the processing tank, e.g. after finishing the requested treatment until the biological sample on the slide can be removed for further off instrument processing. Typically, this use of the processing tank is specifically advantageous in relation to an overnight staining, e.g.
completed in the middle of the night.
Above, the apparatus and the method according to the invention are described according to some preferred explanatory embodiments. However, it is realised by the invention that many other variations and equivalents of the method and the apparatus may be earned out without departing from the scope of the invention as specified in the accompanying claims.
P 140 W0 01 - clean version nato: t0-03-2005 AMENDED SHEET
Preferably, the method according to the invention may include temporary storage of at least one biological sample on a slide in an appropriate liquid in the processing tank, e.g. after finishing the requested treatment until the biological sample on the slide can be removed for further off instrument processing. Typically, this use of the processing tank is specifically advantageous in relation to an overnight staining, e.g.
completed in the middle of the night.
Above, the apparatus and the method according to the invention are described according to some preferred explanatory embodiments. However, it is realised by the invention that many other variations and equivalents of the method and the apparatus may be earned out without departing from the scope of the invention as specified in the accompanying claims.
P 140 W0 01 - clean version nato: t0-03-2005 AMENDED SHEET
Claims (24)
1. A method of treatment of at least one biological sample accommodated on a slide (7) in an automated staining apparatus, said method comprising the steps of:
providing at least one slide (7) carrying a biological sample in a predetermined slide location, said slide (7) being provided in a substantially horizontal position in a slide holder (62);
characterised by pivoting said at least one slide (7) to a substantially vertical position;
immersing said substantially vertically oriented slide (7v) into a processing tank for a predetermined processing time and after the predetermined processing time removing the vertically oriented slide (7v) from the processing tank and pivoting said slide (7v) to a substantially horizontal position.
providing at least one slide (7) carrying a biological sample in a predetermined slide location, said slide (7) being provided in a substantially horizontal position in a slide holder (62);
characterised by pivoting said at least one slide (7) to a substantially vertical position;
immersing said substantially vertically oriented slide (7v) into a processing tank for a predetermined processing time and after the predetermined processing time removing the vertically oriented slide (7v) from the processing tank and pivoting said slide (7v) to a substantially horizontal position.
2. A method according to claim 1, whereby said slide location is a slide rack (61), wherein a plurality of slides (7) may be provided in a slide rack assembly (6), wherein the slides (7) are individually pivotable in pivotable slide clips (69), which are pivotable between a horizontal slide position and a vertical slide position by activation means 67.
3. A method according to claim 1 or 2, including the step of supplying a selected processing liquid from at least one supply tank into a processing tank.
4. A method according to any of claims 1 to 3, including the steps of filling and draining the processing tank (101).
5. A method according to claim 4, whereby liquid is transferred from a supply tank to a transfer tank and onwards to a processing tank (101).
16 b. A method according to any of claims 1 to 5, including the step of subjecting the immersed slide (7) to a series of fluids which are sequentially filled and drained from the processing tank (101).
7. A method according to any of claims 1 to 6, including the step of heating the liquid contained in the processing tank (101) to a predetermined temperature, preferably to an elevated temperature of at least 60°C, more preferably at least 95°C, and even more preferably at least 115°C.
8. A method according to any of claims 1 to 7, including the step of inserting the at least one vertical slide (7v) into the processing tank (101) by lowering the slide rack and thereby immersing the at least one vertically disposed slide (7v) into the processing tank (101).
9. A method according to any of claims 1 to 8, whereby said method of treatment of biological sample is a pretreatment of the biological sample.
10. A method according to any of claims 1 to 9, whereby the biological sample is tissue and said method of treatment of tissue is a deparaffinization treatment of the tissue sample.
11. A method according to any of claims 1 to 10, whereby said method of treatment sample of biological is a target retrieval processing of the biological sample.
12. A method according to any of claims 1 to 11, whereby said method comprises short term storage of the samples on the slides (7v) in the vertical position lowered into a liquid in the processing tank (101).
13. An apparatus for automatic staining at least one biological sample accommodated on a slide (7) by applying a predetermined amount of reagents in a sequence according to a staining protocol, wherein at least one slide (7) is provided in a substantially horizontal position in a slide holder (62) in a slide rack (61), characterised in that the slide rack (61) is arranged in a slide rack assembly (6) comprising means for pretreatment of the tissue sample on the slide (7) after the slide (7) is provided in the slide rack (61), said means for pretreatment of biological samples including a processing tank (101), which is provided in the slide rack assembly (6), ;
means for pivoting the slides (7) provided in the slide rack (61) to a vertical position, means for immersing the vertical slide (7v) into.the processing tank (101), and means for pivoting the vertical slides (7v) to the substantially horizontal position.
means for pivoting the slides (7) provided in the slide rack (61) to a vertical position, means for immersing the vertical slide (7v) into.the processing tank (101), and means for pivoting the vertical slides (7v) to the substantially horizontal position.
14. An apparatus according to claim 13, wherein said means for pretreatment of slides (7) include means (elevator 63) for lowering the vertically disposed slides (7v) of the slide rack (61) into the processing tank (101).
15. An apparatus according to claim 13 or 14, wherein the processing tank (101) is an elongated container having an upper opening slot allowing the vertically oriented slides (7v) to be inserted into the processing tank for treatment.
16. An apparatus according to any of claims 13 to 15, wherein said processing tank (101) is provided with a heating member for heating the processing liquid contained in the processing tank (101).
17. An apparatus according to claim 16, wherein the heating member is capable of heating the processing tank (101) content to an elevated temperature of at least 60°C, more preferably at least 95°C, and even more preferably at least 115°C.
18. An apparatus according to any of claims 13 to 16, wherein the apparatus comprises pneumatic means for transferring processing liquid from a supply tank (111) to a transfer tank (110) and from the transfer tank (110) to the processing tank (101) and draining liquid from the processing tank to the transfer tank and from said transfer tank to a waste collection tank (112).
19. An apparatus according to any of claims 13 to 18, wherein said apparatus includes means for recycling the drained liquid for re-use in a later pre-treatment process of slides.
20. An apparatus according to any of claims 13 to 18, wherein the slide rack assembly is provided in a drawer assembly wherein the rack (61)may be retracted from the apparatus for loading and unloading of slides (7).
21. An apparatus according to claim 20, wherein the drawer assembly cooperates with a processing tank (101) in the drawer receiving means of the apparatus, said processing tank (101) being capable of simultaneous processing of a plurality of slides (7) accommodated in a plurality of slide holders in the slide rack assembly (6).
22. An apparatus according to claim 21, wherein a plurality of drawer assemblies are provided in the apparatus, each cooperating with a processing tank (101) and at least one transfer tank (110) and supply (111) and waste tanks (112).
23. An apparatus according to claim 22, wherein fluid transfer between processing tank (101) and supply or waste tanks (111, 112) are via the at least one transfer tank (110), and that said transfer tank (110) is provided with pneumatic pressure control, including means for applying positive respective negative air pressure to the transfer tank (110).
24. An apparatus according to any of claims 20 to 23, wherein the slides (7) when accommodated in the slide holders (62) are individually pivotable, and that the slide rack assembly (6) is provided with pivoting means that may be activated by a robotic head (22), carrying out the staining processes according to the staining protocol.
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CA2507960A Expired - Fee Related CA2507960C (en) | 2002-12-20 | 2003-12-19 | A method and apparatus for automatic staining of tissue samples |
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CA2508070A Expired - Fee Related CA2508070C (en) | 2002-12-20 | 2003-12-22 | Isolated communication sample processing system and methods of biological slide processing |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102735518A (en) * | 2011-04-13 | 2012-10-17 | 苏州卫生职业技术学院 | Bacterial examination staining rack used for teaching |
CN105676907A (en) * | 2016-03-25 | 2016-06-15 | 丁鸿 | Temperature control device and thermostatic control method |
Families Citing this family (271)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6183693B1 (en) * | 1998-02-27 | 2001-02-06 | Cytologix Corporation | Random access slide stainer with independent slide heating regulation |
US8298485B2 (en) * | 1999-07-08 | 2012-10-30 | Lee H. Angros | In situ heat induced antigen recovery and staining apparatus and method |
US7951612B2 (en) * | 1999-07-08 | 2011-05-31 | Lee H. Angros | In situ heat induced antigen recovery and staining apparatus and method |
US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
AU2002361618A1 (en) | 2001-11-13 | 2003-05-26 | Chromavision Medical Systems, Inc. | A system for tracking biological samples |
US7754155B2 (en) * | 2002-03-15 | 2010-07-13 | Ross Amelia A | Devices and methods for isolating target cells |
US11249095B2 (en) | 2002-04-15 | 2022-02-15 | Ventana Medical Systems, Inc. | Automated high volume slide processing system |
JP4299150B2 (en) * | 2002-04-15 | 2009-07-22 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | System for automatically staining large-capacity slides |
US7468161B2 (en) | 2002-04-15 | 2008-12-23 | Ventana Medical Systems, Inc. | Automated high volume slide processing system |
AU2003901871A0 (en) * | 2003-03-31 | 2003-05-08 | Vision Biosystems Limited | A method and apparatus for fluid dispensation, preparation and dilation |
KR20040023999A (en) * | 2002-09-12 | 2004-03-20 | 엘지전자 주식회사 | structure of motor shaft in clothes dryer |
US7648678B2 (en) | 2002-12-20 | 2010-01-19 | Dako Denmark A/S | Method and system for pretreatment of tissue slides |
US7584019B2 (en) | 2003-12-15 | 2009-09-01 | Dako Denmark A/S | Systems and methods for the automated pre-treatment and processing of biological samples |
US7850912B2 (en) * | 2003-05-14 | 2010-12-14 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
US7875245B2 (en) * | 2003-05-14 | 2011-01-25 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
US20060073074A1 (en) * | 2004-10-06 | 2006-04-06 | Lars Winther | Enhanced sample processing system and methods of biological slide processing |
US20080235055A1 (en) * | 2003-07-17 | 2008-09-25 | Scott Mattingly | Laboratory instrumentation information management and control network |
US7860727B2 (en) * | 2003-07-17 | 2010-12-28 | Ventana Medical Systems, Inc. | Laboratory instrumentation information management and control network |
US8719053B2 (en) * | 2003-07-17 | 2014-05-06 | Ventana Medical Systems, Inc. | Laboratory instrumentation information management and control network |
US20070141711A1 (en) | 2005-12-19 | 2007-06-21 | Randy Stephens | Automated lean methods in anatomical pathology |
US7731906B2 (en) | 2003-07-31 | 2010-06-08 | Handylab, Inc. | Processing particle-containing samples |
US7744817B2 (en) * | 2003-08-11 | 2010-06-29 | Sakura Finetek U.S.A., Inc. | Manifold assembly |
US7767152B2 (en) * | 2003-08-11 | 2010-08-03 | Sakura Finetek U.S.A., Inc. | Reagent container and slide reaction retaining tray, and method of operation |
US9518899B2 (en) | 2003-08-11 | 2016-12-13 | Sakura Finetek U.S.A., Inc. | Automated reagent dispensing system and method of operation |
US7501283B2 (en) * | 2003-08-11 | 2009-03-10 | Sakura Finetek U.S.A., Inc. | Fluid dispensing apparatus |
US7517498B2 (en) * | 2003-08-19 | 2009-04-14 | Agilent Technologies, Inc. | Apparatus for substrate handling |
EP1733240A4 (en) * | 2004-03-02 | 2007-08-22 | Dako Denmark As | Reagent delivery system, dispensing device and container for a biological staining apparatus |
US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
US7867443B2 (en) * | 2004-07-23 | 2011-01-11 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
US7277223B2 (en) * | 2004-07-26 | 2007-10-02 | Meade Instruments Corporation | Apparatus and methods for focusing and collimating telescopes |
US7690275B1 (en) | 2004-08-26 | 2010-04-06 | Elemental Scientific, Inc. | Automated sampling device |
US7469606B1 (en) * | 2004-08-26 | 2008-12-30 | Elemental Scientific, Inc. | Automated sampling device |
US7637175B1 (en) | 2004-08-26 | 2009-12-29 | Elemental Scientific, Inc. | Automated sampling device |
JP4508790B2 (en) * | 2004-09-08 | 2010-07-21 | シスメックス株式会社 | Sample preparation equipment |
US8986614B2 (en) * | 2010-02-23 | 2015-03-24 | Rheonix, Inc. | Self-contained biological assay apparatus, methods, and applications |
US8236255B2 (en) | 2004-12-02 | 2012-08-07 | Lab Vision Corporation | Slide treatment apparatus and methods for use |
JP4659483B2 (en) | 2005-02-25 | 2011-03-30 | シスメックス株式会社 | Measuring apparatus control method and measuring apparatus |
EP1880222B1 (en) * | 2005-05-13 | 2015-10-21 | Leica Biosystems Melbourne Pty Ltd | Tissue sample identification system and apparatus |
AU2012247048B2 (en) * | 2005-05-24 | 2014-11-27 | Angros, Lee H | In situ heat induced antigen recovery and staining apparatus and method |
BRPI0609898A2 (en) | 2005-05-24 | 2011-10-11 | Lee H Angros | in situ antigen retrieval and staining apparatus, reaction module, method for treating a microscope slide, and reconfigurable reagent dispensing strip |
US7687243B1 (en) | 2005-06-06 | 2010-03-30 | Crook Tonia M | Automated method for detecting apoptosis in cells |
US20070020150A1 (en) * | 2005-07-20 | 2007-01-25 | Daquino Lawrence J | Adjustment device for drop dispenser |
US9134237B2 (en) | 2005-09-20 | 2015-09-15 | Janssen Diagnotics, LLC | High sensitivity multiparameter method for rare event analysis in a biological sample |
EP3211086B1 (en) | 2005-09-20 | 2021-06-09 | Menarini Silicon Biosystems S.p.A. | Methods and composition to generate unique sequence dna probes, labeling of dna probes and the use of these probes |
JP4674150B2 (en) * | 2005-11-14 | 2011-04-20 | サクラ精機株式会社 | Dyeing and sticking system |
EP1954763B1 (en) | 2005-11-28 | 2016-11-16 | Dako Denmark A/S | Cyanine dyes and methods for detecting a target using said dyes |
US20070136099A1 (en) * | 2005-12-13 | 2007-06-14 | Gordon Neligh | Distributed medicine system |
JP4808492B2 (en) * | 2005-12-28 | 2011-11-02 | シスメックス株式会社 | Specimen Image Imaging Device, Specimen Image Imaging System, and Specimen Slide Supply Device |
US7835823B2 (en) * | 2006-01-05 | 2010-11-16 | Intuitive Surgical Operations, Inc. | Method for tracking and reporting usage events to determine when preventive maintenance is due for a medical robotic system |
CN100410652C (en) * | 2006-01-12 | 2008-08-13 | 上海交通大学 | Teaching kit for cell-level organism evolution |
US7657070B2 (en) | 2006-01-20 | 2010-02-02 | Sakura Finetek U.S.A., Inc. | Automated system of processing biological specimens and method |
NO20060555L (en) * | 2006-02-02 | 2007-08-03 | Torstein Ljungmann | Apparatus for performing treatment operations in connection with staining of tissue samples on slides |
US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
JP5415253B2 (en) | 2006-03-24 | 2014-02-12 | ハンディラブ・インコーポレーテッド | Integrated system for processing microfluidic samples and methods of use thereof |
US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
US8459509B2 (en) * | 2006-05-25 | 2013-06-11 | Sakura Finetek U.S.A., Inc. | Fluid dispensing apparatus |
KR100759079B1 (en) | 2006-07-13 | 2007-09-19 | 학교법인 포항공과대학교 | Medical automatic diagnosis equipment including robot arm |
KR100874519B1 (en) * | 2006-07-13 | 2008-12-16 | 포항공과대학교 산학협력단 | Mobile robot and clinical test device using the same |
GB2474611B (en) | 2006-09-08 | 2011-09-07 | Thermo Shandon Ltd | Image based detector for slides or baskets for use in a slide processing apparatus |
US7875242B2 (en) * | 2006-10-17 | 2011-01-25 | Preyas Sarabhai Shah | Slide stainer with multiple heater stations |
WO2008061165A2 (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic cartridge and method of making same |
JP5192168B2 (en) * | 2007-03-30 | 2013-05-08 | シスメックス株式会社 | Setting information management system, setting information management method, backup program, and storage medium |
DK2156370T3 (en) | 2007-05-14 | 2012-01-23 | Historx Inc | Compartment separation by pixel characterization using image data clustering |
EP2362228B1 (en) * | 2007-07-10 | 2013-09-18 | Ventana Medical Systems, Inc. | Apparatus and method for biological sample processing |
US8182763B2 (en) * | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
WO2009012185A1 (en) | 2007-07-13 | 2009-01-22 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
CA2604317C (en) | 2007-08-06 | 2017-02-28 | Historx, Inc. | Methods and system for validating sample images for quantitative immunoassays |
DE102007044116A1 (en) * | 2007-09-16 | 2009-04-02 | Leica Biosystems Nussloch Gmbh | Tissue infiltration device |
AU2008308686B2 (en) | 2007-10-02 | 2015-01-22 | Labrador Diagnostics Llc | Modular point-of-care devices and uses thereof |
EP2205365B1 (en) | 2007-10-17 | 2017-02-22 | Aushon Biosystems | Continual flow pin washer |
AU2008317329B2 (en) * | 2007-10-24 | 2014-10-02 | Biomarker Strategies, Llc | Improved methods and devices for cellular analysis |
GB0722226D0 (en) * | 2007-11-13 | 2007-12-27 | Ruskinn Life Sciences Ltd | Gas mixer |
US20110091962A1 (en) * | 2008-01-31 | 2011-04-21 | Richard Carsillo | Automated Stainer Having Stain Level Detection |
CA2714600C (en) | 2008-02-29 | 2021-11-02 | Dako Denmark A/S | Systems and methods for tracking and providing workflow information |
US20090253163A1 (en) * | 2008-04-02 | 2009-10-08 | General Electric Company | Iterative staining of biological samples |
WO2009126303A2 (en) * | 2008-04-11 | 2009-10-15 | Meso Scale Technologies, Llc | Assay apparatuses, methods and reagents |
USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
GB2477648B (en) | 2008-08-29 | 2013-02-20 | Lee H Angros | In situ heat induced antigen recovery and staining apparatus and method |
EP2335221B8 (en) | 2008-09-16 | 2016-05-25 | Novartis AG | Reproducible quantification of biomarker expression |
EP2172780A1 (en) * | 2008-10-01 | 2010-04-07 | Bayer Technology Services GmbH | Apparatus for automatically performing analyses |
US8288520B2 (en) * | 2008-10-27 | 2012-10-16 | Qiagen Gaithersburg, Inc. | Fast results hybrid capture assay and system |
DE102008054071B4 (en) * | 2008-10-31 | 2014-02-20 | Leica Biosystems Nussloch Gmbh | Method of operating a tissue processor and tissue processor |
DE102008054066B4 (en) | 2008-10-31 | 2015-03-19 | Leica Biosystems Nussloch Gmbh | Method for processing tissue samples using a sensor |
US10184862B2 (en) | 2008-11-12 | 2019-01-22 | Ventana Medical Systems, Inc. | Methods and apparatuses for heating slides carrying specimens |
CA2755164C (en) | 2009-03-11 | 2014-02-25 | Sensovation Ag | Autofocus method and autofocus device |
US8489545B2 (en) * | 2009-03-18 | 2013-07-16 | Norman Ritchie | System and method for creating and maintaining pre-task planning documents |
DE102009015596A1 (en) | 2009-03-30 | 2010-10-21 | Dcs Innovative Diagnostik-Systeme Dr. Christian Sartori Gmbh & Co. Kg | Method and device for the treatment of carrier-fixed material |
BE1018828A3 (en) * | 2009-07-16 | 2011-09-06 | Praet Peter Van | INTELLIGENT RACK FOR SPECIMEN TUBES AND METHOD OF LOADING THE TUBES INTO THE RACK. |
US8407011B2 (en) | 2009-08-03 | 2013-03-26 | Empire Technology Development Llc | Mobile sampling of target substances |
JP5275182B2 (en) * | 2009-09-11 | 2013-08-28 | 株式会社日立ハイテクノロジーズ | Dispensing device and analyzer |
DE102009049375B4 (en) * | 2009-10-14 | 2014-07-24 | Leica Instruments (Singapore) Pte. Ltd. | Device for processing tissue samples |
US8524450B2 (en) * | 2009-10-30 | 2013-09-03 | Illumina, Inc. | Microvessels, microparticles, and methods of manufacturing and using the same |
US10746752B2 (en) | 2009-11-13 | 2020-08-18 | Ventana Medical Systems, Inc. | Opposables and automated specimen processing systems with opposables |
WO2011066269A1 (en) | 2009-11-24 | 2011-06-03 | Siemens Healthcare Diagnostics Inc. | Automated, refrigerated specimen inventory management system |
US8765476B2 (en) * | 2009-12-22 | 2014-07-01 | Biocare Medical, Llc | Methods and systems for efficient automatic slide staining in immunohistochemistry sample processing |
US9102979B2 (en) | 2010-02-23 | 2015-08-11 | Rheonix, Inc. | Self-contained biological assay apparatus, methods, and applications |
DE102010036317B4 (en) * | 2010-07-09 | 2020-07-30 | Leica Biosystems Nussloch Gmbh | Automatic adjustment of a dyeing device |
US10139613B2 (en) | 2010-08-20 | 2018-11-27 | Sakura Finetek U.S.A., Inc. | Digital microscope and method of sensing an image of a tissue sample |
JP5915531B2 (en) * | 2010-08-30 | 2016-05-11 | コニカミノルタ株式会社 | Organization evaluation method |
EP2625502B1 (en) | 2010-10-06 | 2018-09-05 | Biocare Medical, LLC | Method and system for efficient processing of biological samples |
WO2012057801A1 (en) * | 2010-10-29 | 2012-05-03 | Feng Tian | Apparatus for processing biological samples and method thereof |
AU2011326484A1 (en) | 2010-11-12 | 2013-05-02 | Gen-Probe Incorporated | System and method for tracking items during a process |
DE102010054360B4 (en) | 2010-12-13 | 2018-09-20 | Leica Biosystems Nussloch Gmbh | Device, rack turning module, system and method for turning racks |
CN102081414B (en) * | 2010-12-21 | 2013-08-28 | 北京赛科希德科技发展有限公司 | Method and system for controlling temperature of sample adding needle |
US8388891B2 (en) * | 2010-12-28 | 2013-03-05 | Sakura Finetek U.S.A., Inc. | Automated system and method of processing biological specimens |
US8572556B2 (en) | 2010-12-31 | 2013-10-29 | Starlims Corporation | Graphically based method for developing connectivity drivers |
AU2012205849A1 (en) * | 2011-01-10 | 2013-07-04 | Ventana Medical Systems, Inc. | Hematoxylin staining method |
AR085087A1 (en) | 2011-01-21 | 2013-09-11 | Theranos Inc | SYSTEMS AND METHODS TO MAXIMIZE THE USE OF SAMPLES |
CN102175498B (en) * | 2011-01-31 | 2012-11-14 | 浙江世纪康大医疗科技有限公司 | Tube-taking and liquid-adding device of dyeing instrument |
US8752732B2 (en) | 2011-02-01 | 2014-06-17 | Sakura Finetek U.S.A., Inc. | Fluid dispensing system |
DE102011011360A1 (en) * | 2011-02-16 | 2012-08-16 | Steinbichler Optotechnik Gmbh | Apparatus and method for determining the 3-D coordinates of an object and for calibrating an industrial robot |
US9945763B1 (en) | 2011-02-18 | 2018-04-17 | Biocare Medical, Llc | Methods and systems for immunohistochemistry heat retrieval of biological samples |
CA2826056C (en) * | 2011-02-28 | 2021-01-26 | Dako Denmark A/S | Two phase immiscible system for the pretreatment of embedded biological samples |
US9140666B2 (en) * | 2012-03-15 | 2015-09-22 | Advanced Analytical Technologies, Inc. | Capillary electrophoresis system |
CN106190806B (en) | 2011-04-15 | 2018-11-06 | 贝克顿·迪金森公司 | Scan real-time microfluid thermal cycler and the method for synchronous thermal cycle and scanning optical detection |
US9123002B2 (en) | 2011-05-27 | 2015-09-01 | Abbott Informatics Corporation | Graphically based method for developing rules for managing a laboratory workflow |
US9665956B2 (en) | 2011-05-27 | 2017-05-30 | Abbott Informatics Corporation | Graphically based method for displaying information generated by an instrument |
WO2013016035A1 (en) * | 2011-07-22 | 2013-01-31 | Constitution Medical, Inc. | Sample transport systems and methods |
US20130060534A1 (en) * | 2011-09-02 | 2013-03-07 | Sigma-Aldrich Co., Llc | Systems and methods for validating and customizing oligonucleotides sequences |
US9664702B2 (en) | 2011-09-25 | 2017-05-30 | Theranos, Inc. | Fluid handling apparatus and configurations |
US8475739B2 (en) | 2011-09-25 | 2013-07-02 | Theranos, Inc. | Systems and methods for fluid handling |
US20140170735A1 (en) | 2011-09-25 | 2014-06-19 | Elizabeth A. Holmes | Systems and methods for multi-analysis |
US9632102B2 (en) | 2011-09-25 | 2017-04-25 | Theranos, Inc. | Systems and methods for multi-purpose analysis |
JP5686710B2 (en) * | 2011-09-21 | 2015-03-18 | 株式会社日立ハイテクノロジーズ | Automatic analyzer |
US8932543B2 (en) | 2011-09-21 | 2015-01-13 | Sakura Finetek U.S.A., Inc. | Automated staining system and reaction chamber |
US8580568B2 (en) | 2011-09-21 | 2013-11-12 | Sakura Finetek U.S.A., Inc. | Traceability for automated staining system |
US10012664B2 (en) | 2011-09-25 | 2018-07-03 | Theranos Ip Company, Llc | Systems and methods for fluid and component handling |
US9810704B2 (en) | 2013-02-18 | 2017-11-07 | Theranos, Inc. | Systems and methods for multi-analysis |
JP2014529084A (en) | 2011-09-30 | 2014-10-30 | ライフ テクノロジーズ コーポレーション | Image analysis identification method and system |
JP5805486B2 (en) * | 2011-09-30 | 2015-11-04 | シスメックス株式会社 | Sample analyzer |
KR102121853B1 (en) | 2011-09-30 | 2020-06-12 | 벡톤 디킨슨 앤드 컴퍼니 | Unitized reagent strip |
BR112014007786A2 (en) | 2011-09-30 | 2017-04-11 | Life Technologies Corp | methods and systems for background subtraction in an image |
DE102011114674C5 (en) | 2011-09-30 | 2020-05-28 | Steinbichler Optotechnik Gmbh | Method and device for determining the 3D coordinates of an object |
EP2761585B1 (en) | 2011-09-30 | 2019-08-07 | Life Technologies Corporation | Method for streamlining optical calibration |
USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
WO2013057050A1 (en) * | 2011-10-17 | 2013-04-25 | Victorious Medical Systems Aps | Method, apparatus and system for staining of biological samples |
CN104040238B (en) | 2011-11-04 | 2017-06-27 | 汉迪拉布公司 | Polynucleotides sample preparation apparatus |
CN102519775A (en) * | 2011-11-15 | 2012-06-27 | 深圳市科软科技有限公司 | Automatic slide stainer |
AU2012339621B2 (en) | 2011-11-16 | 2016-02-18 | Leica Biosystems Melbourne Pty Ltd | Biological sample treatment apparatus |
JP6080860B2 (en) * | 2011-11-16 | 2017-02-15 | ライカ・バイオシステムズ・メルボルン・プロプライエタリー・リミテッドLeica Biosystems Melbourne Pty Ltd | Automated system and method for processing tissue samples on slides |
EP2786114A4 (en) * | 2011-11-30 | 2015-08-26 | Dako Denmark As | Method and system for automated deparaffinization and non-immunohistochemical special staining of tissue samples |
US9268619B2 (en) | 2011-12-02 | 2016-02-23 | Abbott Informatics Corporation | System for communicating between a plurality of remote analytical instruments |
CN107881219B (en) | 2012-02-03 | 2021-09-10 | 贝克顿·迪金森公司 | External file for molecular diagnostic test assignment and compatibility determination between tests |
CN103245547A (en) * | 2012-02-12 | 2013-08-14 | 高新春 | Glass biological-sample section-staining support |
US11340191B2 (en) | 2012-03-15 | 2022-05-24 | Agilent Technologies, Inc. | UV-absorbance multichannel capillary electrophoresis system |
US11016057B2 (en) | 2012-03-15 | 2021-05-25 | Agilent Technologies, Inc. | Pulse-field multiplex capillary electrophoresis system |
DK2831587T3 (en) | 2012-03-27 | 2018-07-23 | Ventana Med Syst Inc | Signaling conjugates and methods of use |
US20130294826A1 (en) * | 2012-05-04 | 2013-11-07 | Advanced Cell Diagnostics, Inc. | Lock-in slide rack |
US10829291B2 (en) * | 2012-06-20 | 2020-11-10 | Thermo Fischer Scientific Baltics UAB | Method to prevent silica-based column aging |
US9817221B2 (en) | 2012-06-29 | 2017-11-14 | General Electric Company | Systems and methods for processing and imaging of biological samples |
WO2014001531A2 (en) * | 2012-06-29 | 2014-01-03 | Victorious Medical Systems Aps | A system and a dip tank for washing and target retrieval of tissue samples mounted on microscope slides |
US9164015B2 (en) * | 2012-06-29 | 2015-10-20 | General Electric Company | Systems and methods for processing and imaging of biological samples |
US9530053B2 (en) * | 2012-07-31 | 2016-12-27 | Tecan Trading Ag | Method and apparatus for detecting or checking an arrangement of laboratory articles on a work area of a laboratory work station |
CH706772A1 (en) * | 2012-07-31 | 2014-01-31 | Tecan Trading Ag | Method and apparatus for detecting and verifying an array of laboratory products on a working area of a laboratory workstation. |
US11097277B2 (en) | 2012-09-04 | 2021-08-24 | Leica Biosystems Melbourne Pty Ltd | Cover member with orientation indicia |
JP6289473B2 (en) * | 2012-09-05 | 2018-03-07 | セファイド | Universal docking bay and data door in fluid analysis system |
US10223765B2 (en) | 2012-09-06 | 2019-03-05 | Sony Corporation | Information processing apparatus, information processing method, and program |
US9341229B1 (en) | 2012-09-10 | 2016-05-17 | Elemental Scientific, Inc. | Automated sampling device |
CN102854050A (en) * | 2012-09-29 | 2013-01-02 | 梁建中 | Fully-automatic double-rail staining instrument for frozen sections |
CA2887635C (en) * | 2012-10-11 | 2021-01-26 | Siemens Healthcare Diagnostics Inc. | Automation maintenance carrier |
US10473558B2 (en) | 2012-11-13 | 2019-11-12 | Ues, Inc. | Automated high speed metallographic system |
EP2920571B1 (en) * | 2012-11-16 | 2020-01-08 | Dako Denmark A/S | Method and apparatus for reagent validation in automated sample processing |
WO2014085854A1 (en) | 2012-12-03 | 2014-06-12 | Leica Biosystems Melbourne Pty Ltd | Thermal module for a sample processing assembly |
US11274998B2 (en) | 2012-12-26 | 2022-03-15 | Ventana Medical Systems, Inc. | Specimen processing systems and methods for holding slides |
BR112015015469A2 (en) * | 2012-12-26 | 2017-07-11 | Ventana Med Syst Inc | slide processing apparatus and method for processing a specimen carried on a slide |
US9989448B2 (en) | 2012-12-26 | 2018-06-05 | Ventana Medical Systems, Inc. | Specimen processing systems and methods for holding slides |
GB2510466B (en) * | 2012-12-28 | 2015-05-06 | Leica Biosystems Nussloch Gmbh | Processor for processing histological samples |
JP6416785B2 (en) * | 2013-01-04 | 2018-10-31 | メソ スケール テクノロジーズ エルエルシー | Instrument for electrochemiluminescence analysis using multiwell plate and contact platform |
EP4220120A3 (en) * | 2013-02-18 | 2024-01-10 | Labrador Diagnostics LLC | Systems and methods for multi-analysis |
US10220392B2 (en) | 2013-03-15 | 2019-03-05 | Becton, Dickinson And Company | Process tube and carrier tray |
CN105164511B (en) | 2013-03-15 | 2019-03-22 | 雅培实验室 | The automated reagent manager of diagnostic analysis device system |
US9632103B2 (en) | 2013-03-15 | 2017-04-25 | Abbott Laboraties | Linear track diagnostic analyzer |
EP2969211B1 (en) | 2013-03-15 | 2019-06-26 | Becton, Dickinson and Company | Process tube and carrier tray |
US11865544B2 (en) | 2013-03-15 | 2024-01-09 | Becton, Dickinson And Company | Process tube and carrier tray |
WO2014144870A2 (en) | 2013-03-15 | 2014-09-18 | Abbott Laboratories | Light-blocking system for a diagnostic analyzer |
DE102013103971A1 (en) | 2013-04-19 | 2014-11-06 | Sensovation Ag | Method for generating an overall picture of an object composed of several partial images |
US10422806B1 (en) | 2013-07-25 | 2019-09-24 | Theranos Ip Company, Llc | Methods for improving assays of biological samples |
CN103398890B (en) * | 2013-08-22 | 2015-11-11 | 麦克奥迪(厦门)医疗诊断系统有限公司 | A kind of liquid-based cell sample manufacturing system and flaking method thereof |
US20150095058A1 (en) * | 2013-10-02 | 2015-04-02 | Health Diagnostic Laboratory, Inc. | Methods for laboratory sample tracking and devices thereof |
CN104630055A (en) * | 2013-11-08 | 2015-05-20 | 西安科技大学 | Main control board of in-situ hybridization system |
USD761439S1 (en) * | 2013-11-18 | 2016-07-12 | Especialidades Médicas Myr, S.L. | Apparatus and equipment for doctors, hospitals and laboratories |
AU2014363678B2 (en) | 2013-12-13 | 2016-12-08 | Ventana Medical Systems, Inc. | Staining reagents and other liquids for histological processing of biological specimens and associated technology |
CN111089980B (en) | 2013-12-13 | 2023-08-15 | 文塔纳医疗系统公司 | Automated histological processing of biological samples and related techniques |
JP6378770B2 (en) | 2013-12-13 | 2018-08-22 | ベンタナ メディカル システムズ, インコーポレイテッド | Thermal management and related techniques in the context of automated histological processing of biological samples |
US10007102B2 (en) | 2013-12-23 | 2018-06-26 | Sakura Finetek U.S.A., Inc. | Microscope with slide clamping assembly |
KR102175186B1 (en) * | 2014-01-17 | 2020-11-06 | 주식회사 수젠텍 | Auto analysis system for strip |
US9347965B1 (en) * | 2014-03-13 | 2016-05-24 | EST Analytical, Inc. | Autosampler with enhanced expansion capability |
CN111337323A (en) * | 2014-04-28 | 2020-06-26 | 深圳迈瑞生物医疗电子股份有限公司 | Smear preparation device and smear preparation method |
US10788466B2 (en) * | 2014-05-20 | 2020-09-29 | Shimadzu Corporation | Sample introduction system |
CN104148265B (en) * | 2014-06-16 | 2015-09-23 | 来安县新元机电设备设计有限公司 | For electrostatic powder spraying workpiece automation pre-processing device |
CA2946684C (en) * | 2014-06-30 | 2020-10-27 | Ventana Medical Systems, Inc. | Automated specimen processing systems and methods |
EP3165916B1 (en) * | 2014-07-02 | 2023-08-23 | Shimadzu Corporation | Preprocessing apparatus |
CN104089804B (en) * | 2014-07-02 | 2019-04-05 | 上海乐辰生物科技有限公司 | Biological sample processing system |
CN104122127A (en) * | 2014-07-18 | 2014-10-29 | 东南大学 | Biological sample treatment device |
CN104101529B (en) * | 2014-07-27 | 2016-07-20 | 李强 | pathological staining device |
USD814653S1 (en) | 2014-08-07 | 2018-04-03 | Becton, Dickinson And Company | Sample tube holder and components thereof |
JP6278199B2 (en) * | 2014-08-20 | 2018-02-14 | 株式会社島津製作所 | Analyzer management system |
CN105578837B (en) * | 2014-10-16 | 2018-06-26 | 华为技术有限公司 | Remote Radio Unit and active antenna system |
WO2016064760A1 (en) * | 2014-10-19 | 2016-04-28 | Peddinti Kamal Prasad | Automated batch stainer for immunohistochemistry |
US10190950B2 (en) | 2014-10-31 | 2019-01-29 | General Electric Company | Semi-automated sampling system for aseptic sampling |
CN105890959A (en) * | 2014-11-24 | 2016-08-24 | 王素蓉 | Staining instrument and control method for staining instrument |
CN104502171B (en) * | 2014-11-27 | 2017-05-31 | 嘉兴凯实生物科技有限公司 | A kind of automatic fluorescence sheet stainer |
CN104849121A (en) * | 2015-02-06 | 2015-08-19 | 上海乐辰生物科技有限公司 | Biological sample treating instrument |
CN104777027B (en) * | 2015-03-25 | 2017-03-22 | 江苏硕世生物科技有限公司 | Multifunctional full-automatic gram staining instrument |
JP2018513984A (en) | 2015-04-06 | 2018-05-31 | ナノサイトミクス,エルエルシー | Automated specimen deposition system and related methods |
US10091279B2 (en) | 2015-05-27 | 2018-10-02 | FlowJo, LLC | Wireless connected laboratory |
WO2016196210A2 (en) | 2015-05-29 | 2016-12-08 | Illumina, Inc. | Sample carrier and assay system for conducting designated reactions |
CN108027379B (en) | 2015-06-26 | 2021-07-23 | 雅培实验室 | Reaction vessel exchange device for diagnostic analysis apparatus |
JP6841609B2 (en) | 2015-07-10 | 2021-03-10 | 3スキャン インコーポレイテッド | Spatial multiplexing of histological staining |
ES2877147T3 (en) | 2016-02-17 | 2021-11-16 | Becton Dickinson Co | Automated methods and modules for preanalytical processing of biological samples for analysis |
CN105903500B (en) * | 2016-04-18 | 2018-04-03 | 佛山盈诺科创投资咨询中心(有限合伙) | A kind of reagent arranges formula adding set |
EP4234182A3 (en) | 2016-04-22 | 2024-03-20 | Becton, Dickinson and Company | Automated analyzer piercing stoppers for aspiration |
US11353472B2 (en) | 2016-04-22 | 2022-06-07 | Becton Dickinson And Company | Automated sample diagnostic analyzer and method for its operation |
ES2901298T3 (en) * | 2016-04-29 | 2022-03-22 | Biocare Medical Llc | Biological sample processing systems and methods |
JP6243965B2 (en) * | 2016-05-26 | 2017-12-06 | シスメックス株式会社 | Smear preparation apparatus and smear preparation method |
US11460383B2 (en) | 2016-06-16 | 2022-10-04 | Nanocytomics, LLC | Automated staining system |
WO2017221155A1 (en) | 2016-06-20 | 2017-12-28 | Genesis Technologies Limited | Automated cell processing systems and methods |
EP3516550A4 (en) * | 2016-09-20 | 2020-05-13 | Nant Holdings IP, LLC | Sample tracking via sample tracking chains, systems and methods |
WO2018085608A2 (en) * | 2016-11-04 | 2018-05-11 | Ues, Inc. | Automated high speed metallographic system |
CN106370830A (en) * | 2016-11-14 | 2017-02-01 | 漯河医学高等专科学校 | Molecular pathology device with independent slip sheet heater |
US11280803B2 (en) | 2016-11-22 | 2022-03-22 | Sakura Finetek U.S.A., Inc. | Slide management system |
CN106782464A (en) * | 2016-12-01 | 2017-05-31 | 北京银河润泰科技有限公司 | Keyboard action detection method and device |
CN106979883B (en) * | 2016-12-19 | 2019-10-29 | 浙江世纪康大医疗科技股份有限公司 | A kind of dyeing instrument drawer type reagent device |
WO2018119321A1 (en) * | 2016-12-22 | 2018-06-28 | Counsyl, Inc. | Automatic diagnostic laboratory and laboratory information management system for high throughput |
EP3601995A4 (en) * | 2017-03-31 | 2020-12-16 | X-Zell Inc. | Automatic slide staining and cooling systems |
US20180372766A1 (en) * | 2017-06-21 | 2018-12-27 | Abbott Molecular Inc. | Analysis Systems and Methods of Identifying Consumables and Reagents |
CN110892057A (en) | 2017-08-01 | 2020-03-17 | 深圳华大智造科技有限公司 | Gene sequencing reaction apparatus, gene sequencing system, and gene sequencing reaction method |
CN110914403A (en) * | 2017-08-01 | 2020-03-24 | 深圳华大智造科技有限公司 | DNA sample loading apparatus, gene sequencing system, and DNA sample loading method |
WO2019071049A1 (en) | 2017-10-04 | 2019-04-11 | Leica Biosystems Imaging, Inc. | Slide inventory and reinsertion system |
CN107907396B (en) * | 2017-11-07 | 2020-11-10 | 山西大学 | Automatic immunohistochemical staining system for biological tissues |
CN107860632B (en) * | 2017-11-07 | 2020-01-03 | 山西大学 | Automatic immunohistochemical device of fruit bat wing bud |
KR102105233B1 (en) * | 2017-12-06 | 2020-06-05 | 권택민 | A laboratory mixer suitable for viscous sample of small quantity |
KR20200102977A (en) * | 2017-12-21 | 2020-09-01 | 라이카 바이오시스템즈 멜버른 피티와이 엘티디 | Fluid transfer system |
CN111886503A (en) * | 2018-02-01 | 2020-11-03 | 贝克曼库尔特有限公司 | Image-based platform inspection |
WO2019195836A1 (en) * | 2018-04-07 | 2019-10-10 | Lumacyte, LLC | Fluidic autosampler and incubator |
DE112019003039T5 (en) * | 2018-06-15 | 2021-04-01 | Elemental Scientific, Inc. | SYSTEM FOR PRIORITIZING THE COLLECTION AND ANALYSIS OF LIQUID SAMPLES |
CN109031446A (en) * | 2018-07-18 | 2018-12-18 | 杭州依美洛克医学科技有限公司 | Glass slide detection device |
WO2020055801A1 (en) | 2018-09-11 | 2020-03-19 | Becton, Dickinson And Company | Robotic sample preparation system for diagnostic testing with automated position learning |
CN109082375A (en) * | 2018-09-14 | 2018-12-25 | 深圳华云智能装备科技有限公司 | A kind of system of sample detection |
CN110525974A (en) * | 2018-09-21 | 2019-12-03 | 安徽恒春玻璃股份有限公司 | A kind of glass auto loading machine |
CN112740046A (en) * | 2018-09-25 | 2021-04-30 | 株式会社日立高新技术 | Automatic analyzer |
CN108872040A (en) * | 2018-09-30 | 2018-11-23 | 徐州工业职业技术学院 | A kind of city haze monitoring system |
WO2020118378A1 (en) * | 2018-12-14 | 2020-06-18 | Leica Biosystems Melbourne Pty Ltd | Reagent cassette |
CN109297796A (en) * | 2018-12-19 | 2019-02-01 | 孝感市森茂激光数控设备有限公司 | A kind of sampling of automatic sedimentation pelleter and dye liquor injection device and method |
JP7390381B2 (en) * | 2018-12-20 | 2023-12-01 | テカン・トレーディング・アクチェンゲゼルシャフト | How to process samples |
CN109490045B (en) * | 2018-12-25 | 2022-05-27 | 宁波察微生物科技有限公司 | Slide glass dyeing and mounting all-in-one machine |
CN111435108A (en) * | 2019-01-11 | 2020-07-21 | 蒋洪棉 | KD series biological tissue treatment dyeing machine |
US20200309649A1 (en) * | 2019-03-08 | 2020-10-01 | Samantree Medical Sa | Receptacles for staining and/or rinsing samples and methods of their use |
US11415409B1 (en) * | 2019-08-22 | 2022-08-16 | Charles S. Powers | Apparatuses and methods for measuring parameters of an object |
CN110631883B (en) * | 2019-08-23 | 2022-05-17 | 山东滨州拓普化工工程有限公司 | High-efficient automatic dyeing appearance |
FR3101149B1 (en) * | 2019-09-19 | 2024-02-09 | Dreampath Diagnostics | Equipment for the traceability of biological samples |
CN110865579A (en) * | 2019-11-26 | 2020-03-06 | 张家港宏昌钢板有限公司 | Factory energy and power configuration management and control system |
US20210285650A1 (en) * | 2020-03-10 | 2021-09-16 | Illinois Tool Works Inc. | Drum heater assembly |
US11146491B1 (en) * | 2020-04-09 | 2021-10-12 | International Business Machines Corporation | Dynamically balancing inbound traffic in a multi-network interface-enabled processing system |
MX2020007710A (en) * | 2020-07-20 | 2022-01-21 | Jesus Raul Beltran Ramirez | Automated device for staining multiple histological samples. |
JP7014460B1 (en) * | 2020-09-30 | 2022-02-01 | 株式会社常光 | Paraffin embedding block making equipment |
CN112945956B (en) * | 2021-02-04 | 2023-06-27 | 广东小天才科技有限公司 | Slide loading detection method and device, terminal equipment and storage medium |
US11501623B1 (en) | 2021-05-14 | 2022-11-15 | China University Of Geosciences (Wuhan) | Arrangement apparatus for multiple integrated sensors in deep position of sliding mass and arrangement method |
US11281194B1 (en) * | 2021-05-25 | 2022-03-22 | Art Research And Technology, L.L.C. | Immune pathway management system |
CN113759842B (en) * | 2021-08-26 | 2022-05-17 | 武汉康录生物技术股份有限公司 | Control system for FISH detection |
EP4246392A1 (en) | 2022-03-15 | 2023-09-20 | F. Hoffmann-La Roche AG | Forecasting future laboratory performance |
WO2024033954A1 (en) * | 2022-08-09 | 2024-02-15 | Logibiotech S.R.L. | Device adapted to retrieve histological slides and/or biocassettes |
CN116465709B (en) * | 2023-04-19 | 2023-12-29 | 杭州海世嘉生物科技有限公司 | Full-automatic immunohistochemical dyeing machine control method, system and storage medium |
Family Cites Families (496)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US159875A (en) * | 1875-02-16 | Improvement in harvester-droppers | ||
US495710A (en) * | 1893-04-18 | Territory | ||
US1829341A (en) * | 1930-01-11 | 1931-10-27 | William C Denison | Air conditioning device |
US3219416A (en) | 1962-10-30 | 1965-11-23 | Scientific Industries | Apparatus for the automatic chemical sequential treatment and analysis of small quantities of material |
US3398935A (en) | 1964-03-25 | 1968-08-27 | Bausch & Lomb | Mixing means |
US4018556A (en) * | 1965-12-03 | 1977-04-19 | Societe Anonyme Dite: L'oreal | Hair dye compounds |
US3482082A (en) | 1966-03-18 | 1969-12-02 | Techicon Corp | Sample identification apparatus |
US4066412A (en) * | 1966-04-26 | 1978-01-03 | E. I. Du Pont De Nemours And Company | Automatic clinical analyzer |
US3513320A (en) | 1966-10-31 | 1970-05-19 | Markstems Inc | Article identification system detecting plurality of colors disposed on article |
US3574064A (en) | 1968-05-09 | 1971-04-06 | Aerojet General Co | Automated biological reaction instrument |
US3547064A (en) | 1968-08-21 | 1970-12-15 | Cava Ind | Planing step |
FR2026808A1 (en) | 1968-12-21 | 1970-09-18 | Olympus Optical Co | |
US3553438A (en) | 1969-07-18 | 1971-01-05 | Sylvania Electric Prod | Mark sensing system |
CH513393A (en) | 1969-08-28 | 1971-09-30 | Greiner Electronic Ag | Process for performing chemical and / or physical analyzes in series |
US3644715A (en) | 1969-09-22 | 1972-02-22 | Becton Dickinson Co | Machine readable label and sample identification system utilizing the same |
US3600900A (en) | 1969-11-03 | 1971-08-24 | North American Rockwell | Temperature controlled centrifuge |
US3916157A (en) | 1970-09-08 | 1975-10-28 | Mmbi Inc | Specimen carrier |
US3680967A (en) | 1970-09-14 | 1972-08-01 | Technicon Instr | Self-locating sample receptacle having integral identification label |
US3772154A (en) | 1971-05-03 | 1973-11-13 | Technicon Instr | Method and apparatus for automated antibiotic susceptibility analysis of bacteria samples |
US3772164A (en) * | 1971-08-16 | 1973-11-13 | Micromatic Ind Inc | Honing and plating apparatus and method embodying bore gauging means |
US3971917A (en) | 1971-08-27 | 1976-07-27 | Maddox James A | Labels and label readers |
BE788877A (en) | 1971-09-17 | 1973-01-02 | Vickers Ltd | AGITATION OF LIQUID SAMPLES TO OBTAIN HOMOGENOUS MIXTURES |
US3861006A (en) * | 1971-11-23 | 1975-01-21 | Wellman Co | Coupling device for a cutting machine |
US3916160A (en) | 1971-12-13 | 1975-10-28 | Bendix Corp | Coded label for automatic reading systems |
US3807851A (en) | 1972-06-06 | 1974-04-30 | Minnesota Mining & Mfg | Slide identification clip |
US3876297A (en) | 1972-06-06 | 1975-04-08 | Minnesota Mining & Mfg | Slide identification |
US3801775A (en) | 1972-08-07 | 1974-04-02 | Scanner | Method and apparatus for identifying objects |
GB1409613A (en) * | 1972-09-21 | 1975-10-08 | Geimuplast Mundt Kg Peter | Apparatus for welding together a base part and a cover part of a photographic slide frame |
US3831006A (en) | 1973-01-19 | 1974-08-20 | Honeywell Inc | Patient-specimen identification system using stored associated numbers |
FR2239167A6 (en) | 1973-07-26 | 1975-02-21 | Ministere Agriculture Service | Machine for carrying out laboratory analyses - has automatic sample transfer, reactant addition and washing of transfer pipettes |
US3851972A (en) | 1973-10-18 | 1974-12-03 | Coulter Electronics | Automatic method and system for analysis and review of a plurality of stored slides |
USRE28585E (en) | 1973-10-25 | 1975-10-28 | Apparatus for nutating and staining a microscope slide | |
US3853092A (en) | 1973-10-25 | 1974-12-10 | Corning Glass Works | Apparatus for nutating and staining a microscope slide |
US3873079A (en) | 1974-01-04 | 1975-03-25 | Byron Jackson Inc | Belleville spring cartridge |
GB1453226A (en) | 1974-01-30 | 1976-10-20 | Newman Howells Associates Ltd | Apparatus for the treatment or processing of histological and other specimens or apparatus |
US3912456A (en) * | 1974-03-04 | 1975-10-14 | Anatronics Corp | Apparatus and method for automatic chemical analysis |
JPS5414287Y2 (en) | 1974-05-08 | 1979-06-13 | ||
US3909203A (en) | 1974-08-04 | 1975-09-30 | Anatronics Corp | Analysis system having random identification and labeling system |
US4084541A (en) * | 1975-04-22 | 1978-04-18 | Olympus Optical Co., Ltd. | Dyeing and decolorization apparatus for use in a blood serum analyzer of an electrophoretic type |
USRE30730E (en) | 1975-06-11 | 1981-09-01 | National Research Development Corporation | Apparatus for use in investigating specimens |
US4013038A (en) * | 1975-07-21 | 1977-03-22 | Corning Glass Works | Apparatus for controlling the temperature of a liquid body |
US4013157A (en) * | 1975-07-30 | 1977-03-22 | Bally Manufacturing Corporation | Bonus play machine |
GB1506058A (en) | 1975-08-13 | 1978-04-05 | Secr Social Service Brit | Liquid storage apparatus |
US3994594A (en) | 1975-08-27 | 1976-11-30 | Technicon Instruments Corporation | Cuvette and method of use |
US4018565A (en) * | 1975-10-17 | 1977-04-19 | The Foxboro Company | Automatic process titration system |
JPS5295121A (en) | 1976-02-06 | 1977-08-10 | Hitachi Ltd | Code plate |
US4012038A (en) * | 1976-03-03 | 1977-03-15 | Brotz Gregory R | Magnetic toy |
GB1561061A (en) | 1976-03-17 | 1980-02-13 | Hycel Inc | Reaction conveyor assembly in an automatic chemical testing apparatus |
DE2642019C2 (en) * | 1976-09-18 | 1982-06-03 | Robert Bosch Gmbh, 7000 Stuttgart | Method for reproducing video signals recorded in individual tracks on a recording medium - preferably magnetic tape |
US4159875A (en) | 1976-10-21 | 1979-07-03 | Abbott Laboratories | Specimen holder |
GB1595296A (en) | 1976-12-03 | 1981-08-12 | Nat Res Dev | Automation of discrete analysis systems |
US4298571A (en) | 1976-12-17 | 1981-11-03 | Eastman Kodak Company | Incubator including cover means for an analysis slide |
US4200056A (en) * | 1977-01-21 | 1980-04-29 | Miles Laboratories, Inc. | Segmented platen for applying liquids to a flat surface |
US4115861A (en) | 1977-03-28 | 1978-09-19 | Instrumentation Specialties Company | Chemical analyzer |
US4113038A (en) * | 1977-04-18 | 1978-09-12 | Clark George M | Drilling jar |
JPS5414287A (en) | 1977-07-04 | 1979-02-02 | Toshiba Corp | Stress sensor using elastic surface wave elements |
US4100309A (en) | 1977-08-08 | 1978-07-11 | Biosearch Medical Products, Inc. | Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same |
US4092952A (en) | 1977-08-19 | 1978-06-06 | Wilkie Ronald N | Automatic slide stainer |
US4135883A (en) | 1977-08-29 | 1979-01-23 | Bio-Dynamics Inc. | Blood analyzer system |
US4133437A (en) * | 1977-09-09 | 1979-01-09 | Helper Industries, Inc. | Wheel chair lift apparatus |
FR2403465A2 (en) * | 1977-09-16 | 1979-04-13 | Valois Sa | MANUAL PISTON PUMP FOR DISTRIBUTION OR SPRAYING |
JPS5473094A (en) * | 1977-11-21 | 1979-06-12 | Olympus Optical Co Ltd | Automatic chemical analytical apparatus |
US4227810A (en) | 1978-01-26 | 1980-10-14 | Technicon Instruments Corporation | Cuvette and method of use |
US4133642A (en) * | 1978-03-10 | 1979-01-09 | Terumo Corporation | Pipetting apparatus for automatic analyzer |
US4413584A (en) * | 1978-04-19 | 1983-11-08 | A.J.P. Scientific, Inc. | Biological slide staining apparatus |
JPS55107957U (en) | 1979-01-25 | 1980-07-29 | ||
JPS55107957A (en) | 1979-02-13 | 1980-08-19 | Agency Of Ind Science & Technol | Analyzing method of blood image |
JPS55136958A (en) | 1979-04-14 | 1980-10-25 | Olympus Optical Co Ltd | Automatic analyzer |
JPS55136957A (en) | 1979-04-14 | 1980-10-25 | Olympus Optical Co Ltd | Automatic analyzer |
JPS55140155A (en) * | 1979-04-19 | 1980-11-01 | Olympus Optical Co Ltd | Distribution device |
JPS55144550A (en) * | 1979-04-28 | 1980-11-11 | Olympus Optical Co Ltd | Automatic analyzer |
US4281387A (en) | 1979-05-21 | 1981-07-28 | American Home Products Corp. | Automatic chemical analysis apparatus and method |
US4263504A (en) | 1979-08-01 | 1981-04-21 | Ncr Corporation | High density matrix code |
US4406547A (en) | 1979-08-07 | 1983-09-27 | Olympus Optical Company Limited | Apparatus for effecting automatic analysis |
US4346056A (en) | 1979-08-15 | 1982-08-24 | Olympus Optical Company Limited | Automatic analyzing apparatus |
US4318885A (en) * | 1979-09-10 | 1982-03-09 | Olympus Optical Co., Ltd. | Liquid treating device for chemical analysis apparatus |
US4331176A (en) * | 1980-03-03 | 1982-05-25 | American Standard Inc. | Replaceable cartridge valve assembly |
DE3035340C2 (en) | 1980-09-19 | 1983-03-31 | Boehringer Ingelheim Diagnostika GmbH, 8046 Garching | Method and device for the distribution of samples from primary vessels |
US4323537A (en) | 1980-10-20 | 1982-04-06 | Instrumentation Laboratory Inc. | Analysis system |
JPS5782769A (en) * | 1980-11-10 | 1982-05-24 | Hitachi Ltd | Automatic analyzing device |
JPH0217341Y2 (en) | 1981-02-10 | 1990-05-15 | ||
US4404641A (en) | 1981-02-17 | 1983-09-13 | Dierckx Equipment Corporation | Maintenance monitor |
US4371498A (en) | 1981-06-19 | 1983-02-01 | Medical Laboratory Automation, Inc. | Coded cuvette for use in testing apparatus |
US4467603A (en) | 1981-07-08 | 1984-08-28 | Wilson William L | Torque transfer apparatus |
WO1983000296A1 (en) | 1981-07-20 | 1983-02-03 | American Hospital Supply Corp | Cuvette system for automated chemical analyzer |
JPS58105065A (en) * | 1981-12-17 | 1983-06-22 | Olympus Optical Co Ltd | Analyzer based on emmunological agglutination |
US4447395A (en) * | 1982-02-12 | 1984-05-08 | The United States Of America As Represented By The Secretary Of The Army | Sampling device |
US5202252A (en) * | 1982-03-05 | 1993-04-13 | Houston Biotechnology Inc. | Monoclonal antibodies against lens epithelial cells and methods for preventing proliferation of remnant lens epithelial cells after extracapsular extraction |
GB2116711B (en) | 1982-03-17 | 1985-07-31 | Vickers Plc | Automatic chemical analysis |
US4571699A (en) | 1982-06-03 | 1986-02-18 | International Business Machines Corporation | Optical mark recognition for controlling input devices, hosts, and output devices |
US4539632A (en) | 1982-09-28 | 1985-09-03 | Borg-Warner Corporation | Programmable maintenance timer system |
US4467073A (en) | 1982-10-20 | 1984-08-21 | Hydromer, Inc. | Transparent anti-fog coating compositions |
US4488679A (en) | 1982-11-01 | 1984-12-18 | Western Publishing Company, Inc. | Code and reading system |
US4647432A (en) * | 1982-11-30 | 1987-03-03 | Japan Tectron Instruments Corporation Tokuyama Soda Kabushiki Kaisha | Automatic analysis apparatus |
US5175086A (en) | 1983-01-24 | 1992-12-29 | Olympus Optical Co., Ltd. | Method for effecting heterogeneous immunological analysis |
GB8302108D0 (en) | 1983-01-26 | 1983-03-02 | Ventana Ltd | Ventilators |
US4585622A (en) * | 1983-02-02 | 1986-04-29 | Ae/Cds, Autoclave, Inc. | Chemical microreactor having close temperature control |
EP0117262B1 (en) | 1983-02-25 | 1988-04-20 | Winfried Dr. med. Stöcker | Processes and devices for examinations on immobilised biological material |
US4538222A (en) * | 1983-04-06 | 1985-08-27 | Halliburton Company | Apparatus and method for mixing a plurality of substances |
US4510169A (en) * | 1983-08-23 | 1985-04-09 | The Board Of Regents, The University Of Texas | Method and apparatus for cryopreparing biological tissue for ultrastructural analysis |
US4634850A (en) | 1983-10-12 | 1987-01-06 | Drexler Technology Corporation | Quad density optical data system |
US4609017A (en) | 1983-10-13 | 1986-09-02 | Coulter Electronics, Inc. | Method and apparatus for transporting carriers of sealed sample tubes and mixing the samples |
US4683120A (en) | 1983-10-28 | 1987-07-28 | Gamma Biologicals, Inc. | Biological fluid assay system |
US4624588A (en) | 1983-11-08 | 1986-11-25 | Maverick Microsystems, Inc. | Full field MICR encoder |
JPS61501167A (en) | 1984-02-01 | 1986-06-12 | ヒユレツト,ウイリアム・チエスタ− | Clinical analyzer and method |
JPH0723895B2 (en) * | 1984-02-13 | 1995-03-15 | オリンパス光学工業株式会社 | Method for controlling reagent amount of automatic analyzer |
DE3405292A1 (en) | 1984-02-15 | 1985-09-05 | Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg | METHOD FOR CARRYING OUT SAMPLES AND RACK FOR CARRYING OUT THE METHOD |
US4961906A (en) | 1984-04-12 | 1990-10-09 | Fisher Scientific Company | Liquid handling |
JPS6126863A (en) * | 1984-07-17 | 1986-02-06 | Konishiroku Photo Ind Co Ltd | Biochemical analysis instrument |
US4567748A (en) * | 1984-07-19 | 1986-02-04 | Klass Carl S | On-line linear tonometer |
AU571727B2 (en) | 1984-08-23 | 1988-04-21 | Australian Biomedical Corporation Limited | Processing apparatus |
DE3434931A1 (en) * | 1984-09-22 | 1986-03-27 | Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg | METHOD AND DEVICE FOR MIXING A LIQUID SAMPLE TO BE ANALYZED |
EP0197984B1 (en) | 1984-10-01 | 1990-05-23 | BAXTER INTERNATIONAL INC. (a Delaware corporation) | Tablet dispensing |
JPS61129561A (en) * | 1984-11-28 | 1986-06-17 | Olympus Optical Co Ltd | Electrophoresis device |
US4675299A (en) | 1984-12-12 | 1987-06-23 | Becton, Dickinson And Company | Self-contained reagent package device and an assay using same |
US4764342A (en) | 1985-02-27 | 1988-08-16 | Fisher Scientific Company | Reagent handling |
US4708886A (en) | 1985-02-27 | 1987-11-24 | Fisher Scientific Company | Analysis system |
US5656493A (en) | 1985-03-28 | 1997-08-12 | The Perkin-Elmer Corporation | System for automated performance of the polymerase chain reaction |
US4782221A (en) | 1985-04-01 | 1988-11-01 | Cauzin Systems, Incorporated | Printed data strip including bit-encoded information and scanner control |
US4692603A (en) | 1985-04-01 | 1987-09-08 | Cauzin Systems, Incorporated | Optical reader for printed bit-encoded data and method of reading same |
US4678894A (en) | 1985-04-18 | 1987-07-07 | Baxter Travenol Laboratories, Inc. | Sample identification system |
US4706207A (en) | 1985-06-24 | 1987-11-10 | Nova Celltrak, Inc. | Count accuracy control means for a blood analyses system |
US4774055A (en) | 1985-06-26 | 1988-09-27 | Japan Tectron Instruments Corporation | Automatic analysis apparatus |
US4719087A (en) * | 1985-07-01 | 1988-01-12 | Baxter Travenol Laboratories, Inc. | Tray for analyzing system |
US4681741A (en) | 1985-07-01 | 1987-07-21 | American Hospital Supply Corporation | Reagent dispenser for an analyzing system |
US4643879A (en) * | 1985-07-01 | 1987-02-17 | American Hospital Supply Corporation | Tower for analyzing system |
DE3650054T2 (en) | 1985-07-01 | 1995-09-07 | Baxter Diagnostics Inc | REAGENT DISTRIBUTOR FOR AN ANALYSIS SYSTEM. |
US4933147A (en) | 1985-07-15 | 1990-06-12 | Abbott Laboratories | Unitized reagent containment system for clinical analyzer |
US4729661A (en) * | 1985-07-29 | 1988-03-08 | Specialty Medical Industries, Inc. | Asynchronous serial cuvette reader |
JPH0640054B2 (en) * | 1985-09-20 | 1994-05-25 | 株式会社千代田製作所 | Embedding device for electron microscope specimen preparation |
US4797938A (en) | 1985-10-15 | 1989-01-10 | International Business Machines Corporation | Method of identifying magnetic ink (MICR) characters |
US4695430A (en) | 1985-10-31 | 1987-09-22 | Bio/Data Corporation | Analytical apparatus |
US4728783A (en) | 1985-11-15 | 1988-03-01 | Cauzin Systems, Incorporated | Method and apparatus for transforming digitally encoded data into printed data strips |
US4754127A (en) | 1985-11-15 | 1988-06-28 | Cauzin Systems, Incorporated | Method and apparatus for transforming digitally encoded data into printed data strips |
US4678752A (en) | 1985-11-18 | 1987-07-07 | Becton, Dickinson And Company | Automatic random access analyzer |
JPH0652263B2 (en) * | 1985-12-10 | 1994-07-06 | 株式会社日立製作所 | Cell analyzer |
DE3786087T2 (en) | 1986-02-07 | 1993-09-16 | Fuji Photo Film Co Ltd | DEVICE FOR CHEMICAL ANALYSIS. |
JPH0690212B2 (en) * | 1986-02-21 | 1994-11-14 | 株式会社東芝 | Automatic chemical analyzer |
US4651671A (en) * | 1986-02-21 | 1987-03-24 | Pedersen Anders N | Continuous feed apparatus for staining specimens carried on slides |
US4815978A (en) * | 1986-04-30 | 1989-03-28 | Baxter Travenol Laboratories, Inc. | Clinical analysis methods and systems |
US4871682A (en) | 1986-04-30 | 1989-10-03 | Baxter Travenol Laboratories, Inc. | Diluent carryover control |
JPS63503245A (en) | 1986-04-30 | 1988-11-24 | バクスター、ダイアグノスチックス、インコーポレイテッド | Diluent carryover control |
JPS62299769A (en) | 1986-06-20 | 1987-12-26 | Fuji Photo Film Co Ltd | Dispenser |
US4824641A (en) * | 1986-06-20 | 1989-04-25 | Cetus Corporation | Carousel and tip |
US4865811A (en) | 1986-07-01 | 1989-09-12 | Biotec Instruments Limited | Apparatus for automatic chemical analysis |
US4900513A (en) * | 1986-07-11 | 1990-02-13 | Beckman Instruments, Inc. | Sample loading apparatus |
US4965049A (en) | 1986-07-11 | 1990-10-23 | Beckman Instruments, Inc. | Modular analyzer system |
US4728959A (en) | 1986-08-08 | 1988-03-01 | Ventana Sciences Inc. | Direction finding localization system |
JPS6361956A (en) * | 1986-09-03 | 1988-03-18 | Fuji Photo Film Co Ltd | Chemical analysis instrument |
EP0282601B1 (en) * | 1986-09-16 | 1993-02-10 | Mitsubishi Corporation | Automatic analyzer |
GB2196116B (en) | 1986-10-07 | 1990-08-15 | Weston Terence E | Apparatus for chemical analysis. |
CH669266A5 (en) | 1986-10-14 | 1989-02-28 | Serono Diagnostics Ltd | Automatic analysis apparatus for the determination of antibody or antigens in a biological liquid. |
GB2196428B (en) * | 1986-10-14 | 1990-05-23 | Tiyoda Seisakusho Kk | Apparatus for dyeing specimens automatically preparatory to microscopic examination |
US4817916A (en) * | 1987-03-09 | 1989-04-04 | Jamesbury Corporation | Butterfly valve |
JPH087220B2 (en) | 1987-03-12 | 1996-01-29 | 富士写真フイルム株式会社 | Analytical method using chemical analysis slide |
US4986891A (en) * | 1987-03-16 | 1991-01-22 | Helena Laboratories Corporation | Automatic electrophoresis apparatus and method |
JPS63240688A (en) | 1987-03-27 | 1988-10-06 | Kajima Corp | Circular code |
US4855110A (en) | 1987-05-06 | 1989-08-08 | Abbott Laboratories | Sample ring for clinical analyzer network |
US4849177A (en) | 1987-05-08 | 1989-07-18 | Abbott Laboratories | Reagent pack and carousel |
US4847208A (en) | 1987-07-29 | 1989-07-11 | Bogen Steven A | Apparatus for immunohistochemical staining and method of rinsing a plurality of slides |
US4873877A (en) | 1987-08-17 | 1989-10-17 | Davis Meditech | Precision liquid handling apparatus |
US4868129A (en) | 1987-08-27 | 1989-09-19 | Biotrack Inc. | Apparatus and method for dilution and mixing of liquid samples |
US4854163A (en) | 1987-09-28 | 1989-08-08 | Amoco Corporation | Beltless core conveyor system for wellsite analysis |
GB8722902D0 (en) * | 1987-09-30 | 1987-11-04 | Shandon Southern Prod | Tissue &c processing |
US4794239A (en) | 1987-10-13 | 1988-12-27 | Intermec Corporation | Multitrack bar code and associated decoding method |
US4886590A (en) | 1987-11-02 | 1989-12-12 | Man-Gill Chemical Company | Chemical process control system |
EP0315757A3 (en) * | 1987-11-12 | 1991-03-06 | Oerlikon-Contraves AG | Method and apparatus for storing and mixing blood samples |
US5051238A (en) | 1987-11-20 | 1991-09-24 | Hitachi, Ltd. | Automatic analyzing system |
US4924078A (en) * | 1987-11-25 | 1990-05-08 | Sant Anselmo Carl | Identification symbol, system and method |
US4935875A (en) | 1987-12-02 | 1990-06-19 | Data Chem, Inc. | Chemical analyzer |
JPH076998B2 (en) | 1987-12-04 | 1995-01-30 | 富士写真フイルム株式会社 | Automatic dispenser and spotting method |
JPH01187461A (en) | 1988-01-22 | 1989-07-26 | Toshiba Corp | Automatic chemical analyzer |
JPH01126474U (en) | 1988-02-22 | 1989-08-29 | ||
US4795710A (en) * | 1988-02-26 | 1989-01-03 | Eastman Kodak Company | Mounting of analyzer sample tray |
US5681543A (en) | 1988-02-29 | 1997-10-28 | Shering Aktiengesellschaft | Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI |
IE64511B1 (en) | 1988-03-11 | 1995-08-09 | Takeda Chemical Industries Ltd | Automated synthesizing apparatus |
US5104527A (en) * | 1988-03-24 | 1992-04-14 | Ashland Oil, Inc. | Automatic total reducers monitoring and adjustment system using titration |
US4896029A (en) * | 1988-04-08 | 1990-01-23 | United Parcel Service Of America, Inc. | Polygonal information encoding article, process and system |
US4874936A (en) | 1988-04-08 | 1989-10-17 | United Parcel Service Of America, Inc. | Hexagonal, information encoding article, process and system |
GB2216259A (en) | 1988-03-31 | 1989-10-04 | Microvol Ltd | Dispenser for chemical analysis carrying a code |
US4998010A (en) * | 1988-04-08 | 1991-03-05 | United Parcel Service Of America, Inc. | Polygonal information encoding article, process and system |
US5544650A (en) | 1988-04-08 | 1996-08-13 | Neuromedical Systems, Inc. | Automated specimen classification system and method |
US4939674A (en) | 1988-04-22 | 1990-07-03 | Engineered Data Products, Inc. | Label generation apparatus |
US4967606A (en) | 1988-04-29 | 1990-11-06 | Caveo Scientific Instruments, Inc. | Method and apparatus for pipetting liquids |
US5053609A (en) | 1988-05-05 | 1991-10-01 | International Data Matrix, Inc. | Dynamically variable machine readable binary code and method for reading and producing thereof |
US4939354A (en) | 1988-05-05 | 1990-07-03 | Datacode International, Inc. | Dynamically variable machine readable binary code and method for reading and producing thereof |
US5124536A (en) | 1988-05-05 | 1992-06-23 | International Data Matrix, Inc. | Dynamically variable machine readable binary code and method for reading and producing thereof |
GB2218514B (en) | 1988-05-12 | 1991-12-11 | Gen Motors Corp | Process evaluation by isotope enrichment |
GB8816982D0 (en) | 1988-07-16 | 1988-08-17 | Probus Biomedical Ltd | Bio-fluid assay apparatus |
US5229074A (en) | 1988-07-25 | 1993-07-20 | Precision Systems, Inc. | Automatic multiple-sample multiple-reagent chemical analyzer |
US5597733A (en) | 1988-07-25 | 1997-01-28 | Precision Systems, Inc. | Automatic multiple-sample multiple-reagent dispensing method in chemical analyzer |
US5382511A (en) * | 1988-08-02 | 1995-01-17 | Gene Tec Corporation | Method for studying nucleic acids within immobilized specimens |
US5281516A (en) * | 1988-08-02 | 1994-01-25 | Gene Tec Corporation | Temperature control apparatus and method |
ES2085854T3 (en) * | 1988-08-02 | 1996-06-16 | Abbott Lab | METHOD AND DEVICE FOR THE PRODUCTION OF CALIBRATION DATA FOR ANALYSIS. |
AU4211989A (en) * | 1988-08-18 | 1990-03-23 | California Biotechnology, Inc. | Atrial natriuretic peptide clearance inhibitors |
US5031797A (en) | 1988-11-18 | 1991-07-16 | Beckman Instruments, Inc. | Reagent storage and delivery system |
US5439826A (en) | 1988-12-02 | 1995-08-08 | Bio-Tek Instruments, Inc. | Method of distinguishing among strips for different assays in an automated instrument |
US5059393A (en) | 1989-01-05 | 1991-10-22 | Eastman Kodak Company | Analysis slide positioning apparatus and method for a chemical analyzer |
US5106583A (en) * | 1989-03-08 | 1992-04-21 | Applied Biosystems, Inc. | Automated protein hydrolysis system |
US5180606A (en) * | 1989-05-09 | 1993-01-19 | Wescor, Inc. | Apparatus for applying a controlled amount of reagent to a microscope slide or the like |
US5695739A (en) | 1989-06-30 | 1997-12-09 | Schering Aktiengesellschaft | Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production |
US4943415A (en) | 1989-07-14 | 1990-07-24 | Eastman Kodak Company | Grooved cover for test elements |
US5209903A (en) | 1989-09-06 | 1993-05-11 | Toa Medical Electronics, Co., Ltd. | Synthetic apparatus for inspection of blood |
US5346672A (en) | 1989-11-17 | 1994-09-13 | Gene Tec Corporation | Devices for containing biological specimens for thermal processing |
DE3938992A1 (en) | 1989-11-21 | 1991-05-23 | Schering Ag | Cascade polymer-bound complex formers, their complexes and conjugates, process for their preparation and pharmaceutical compositions containing them |
US5250262A (en) | 1989-11-22 | 1993-10-05 | Vettest S.A. | Chemical analyzer |
US5646046A (en) | 1989-12-01 | 1997-07-08 | Akzo Nobel N.V. | Method and instrument for automatically performing analysis relating to thrombosis and hemostasis |
GB9020352D0 (en) | 1990-09-18 | 1990-10-31 | Anagen Ltd | Assay or reaction apparatus |
JPH03209163A (en) | 1990-01-11 | 1991-09-12 | Chiyoda Seisakusho:Kk | Method and device for extending chromosome on slide glass |
US5355304A (en) | 1990-01-30 | 1994-10-11 | Demoranville Victoria E | Clinical laboratory work-flow system which semi-automates validated immunoassay and electrophoresis protocols |
US5595707A (en) * | 1990-03-02 | 1997-01-21 | Ventana Medical Systems, Inc. | Automated biological reaction apparatus |
CA2299118C (en) | 1990-03-02 | 2006-08-08 | Ventana Medical Systems, Inc. | Automated biological reaction apparatus |
US5225325A (en) | 1990-03-02 | 1993-07-06 | Ventana Medical Systems, Inc. | Immunohistochemical staining method and reagents therefor |
US6472217B1 (en) | 1990-03-02 | 2002-10-29 | Ventana Medical Systems, Inc. | Slide aqueous volume controlling apparatus |
US5075079A (en) | 1990-05-21 | 1991-12-24 | Technicon Instruments Corporation | Slide analysis system |
WO1992001919A1 (en) | 1990-07-18 | 1992-02-06 | Australian Biomedical Corporation Ltd. | Automatic tissue staining for immunohistochemistry |
US5425918A (en) | 1990-07-18 | 1995-06-20 | Australian Biomedical Corporation | Apparatus for automatic tissue staining for immunohistochemistry |
AU644876B2 (en) | 1990-07-18 | 1993-12-23 | Vision Instruments Limited | Automatic tissue staining for immunohistochemistry |
US5118369A (en) | 1990-08-23 | 1992-06-02 | Colorcode Unlimited Corporation | Microlabelling system and process for making microlabels |
US5350697A (en) | 1990-08-28 | 1994-09-27 | Akzo N.V. | Scattered light detection apparatus |
US5920488A (en) * | 1990-10-01 | 1999-07-06 | American Auto-Matrix, Inc. | Method and system for maintaining a desired air flow through a fume hood |
US5428740A (en) | 1990-10-18 | 1995-06-27 | Ventana Systems, Inc. | Applying successive data group operations to an active data group |
DE4041905A1 (en) * | 1990-12-27 | 1992-07-02 | Boehringer Mannheim Gmbh | TEST CARRIER ANALYSIS SYSTEM |
CA2384514C (en) * | 1991-03-04 | 2006-07-25 | Bayer Corporation | Automated analyzer |
US6498037B1 (en) | 1991-03-04 | 2002-12-24 | Bayer Corporation | Method of handling reagents in a random access protocol |
SE9100661L (en) | 1991-03-06 | 1992-09-07 | Varta Batteri Ab | PROCEDURES FOR REMOVING DEFECTS IN A SAFETY LAYER |
DE4212821C2 (en) | 1991-04-19 | 1994-07-28 | Olympus Optical Co | Device for removing a closure from the opening of a container and for removing liquid contents |
US5202552A (en) | 1991-04-22 | 1993-04-13 | Macmillan Bloedel Limited | Data with perimeter identification tag |
DE4115789A1 (en) * | 1991-05-10 | 1992-11-12 | Schering Ag | MACROCYCLIC POLYMER COMPLEX IMAGERS, THEIR COMPLEXES, METHOD FOR THEIR PRODUCTION AND THE PHARMACEUTICAL AGENTS CONTAINING THEM |
DE4117833C2 (en) * | 1991-05-29 | 1993-10-07 | Medite Ges Fuer Medizintechnik | Method and device for staining histological specimens arranged on slides |
US5576215A (en) | 1991-06-03 | 1996-11-19 | Abbott Laboratories | Adaptive scheduling system and method for operating a biological sample analyzer with variable interval periods |
US5289385A (en) * | 1991-06-03 | 1994-02-22 | Abbott Laboratories | Adaptive scheduling system and method for operating a biological sample analyzer with variable rinsing |
US5282149A (en) * | 1991-06-03 | 1994-01-25 | Abbott Laboratories | Adaptive scheduling system and method for a biological analyzer with reproducible operation time periods |
JPH0510958A (en) * | 1991-07-02 | 1993-01-19 | Olympus Optical Co Ltd | Analysis device |
EP0596883A4 (en) | 1991-07-26 | 1994-12-07 | Cirrus Diagnostics Inc | Automated immunoassay analyzer. |
US5366896A (en) | 1991-07-30 | 1994-11-22 | University Of Virginia Alumni Patents Foundation | Robotically operated laboratory system |
US5696887A (en) | 1991-08-05 | 1997-12-09 | Biotek Solutions, Incorporated | Automated tissue assay using standardized chemicals and packages |
US5355439A (en) | 1991-08-05 | 1994-10-11 | Bio Tek Instruments | Method and apparatus for automated tissue assay |
US5232664A (en) | 1991-09-18 | 1993-08-03 | Ventana Medical Systems, Inc. | Liquid dispenser |
US5184834A (en) * | 1991-10-01 | 1993-02-09 | Yu Chung Hsiung | Skate shoe having an adjustable plate mounted thereto |
US5338356A (en) | 1991-10-29 | 1994-08-16 | Mitsubishi Materials Corporation | Calcium phosphate granular cement and method for producing same |
US5245606A (en) * | 1992-01-02 | 1993-09-14 | National Semiconductor Corporation | Computer network bridge circuit |
US5578452A (en) | 1992-01-16 | 1996-11-26 | Biogenex Laboratories | Enhancement of immunochemical staining in aldehyde-fixed tissues |
US5369261A (en) | 1992-02-12 | 1994-11-29 | Shamir; Harry | Multi-color information encoding system |
JP3382632B2 (en) * | 1992-03-13 | 2003-03-04 | オリンパス光学工業株式会社 | Method for measuring biological substance and reaction vessel used for the method |
US5646049A (en) * | 1992-03-27 | 1997-07-08 | Abbott Laboratories | Scheduling operation of an automated analytical system |
JP3521144B2 (en) | 1992-03-27 | 2004-04-19 | アボツト・ラボラトリーズ | Automatic continuous random access analysis system and its components |
JP3320444B2 (en) | 1992-04-06 | 2002-09-03 | 株式会社千代田製作所 | Nozzle cleaning equipment for dyeing equipment |
US5331176A (en) | 1992-04-10 | 1994-07-19 | Veritec Inc. | Hand held two dimensional symbol reader with a symbol illumination window |
JPH05288756A (en) | 1992-04-13 | 1993-11-02 | Hitachi Ltd | Automatic analyzer and automatic analyzing system |
JP3193443B2 (en) | 1992-04-24 | 2001-07-30 | オリンパス光学工業株式会社 | Automatic analyzer |
DE4313807C2 (en) | 1992-04-28 | 1995-03-09 | Olympus Optical Co | Reagent container system for the immunological analysis of a sample in an automatic analyzer |
US6180061B1 (en) * | 1992-05-11 | 2001-01-30 | Cytologix Corporation | Moving platform slide stainer with heating elements |
US6092695A (en) | 1992-05-11 | 2000-07-25 | Cytologix Corporation | Interchangeable liquid dispensing cartridge pump |
US5645114A (en) | 1992-05-11 | 1997-07-08 | Cytologix Corporation | Dispensing assembly with interchangeable cartridge pumps |
US5947167A (en) | 1992-05-11 | 1999-09-07 | Cytologix Corporation | Dispensing assembly with interchangeable cartridge pumps |
US5316452A (en) * | 1992-05-11 | 1994-05-31 | Gilbert Corporation | Dispensing assembly with interchangeable cartridge pumps |
WO1993023732A1 (en) * | 1992-05-13 | 1993-11-25 | Australian Biomedical Corporation Limited | Automatic staining apparatus for slide specimens |
DE59304836D1 (en) | 1992-09-04 | 1997-01-30 | Fault Tolerant Systems | COMMUNICATION CONTROL UNIT AND METHOD FOR TRANSMITTING MESSAGES |
US5316319A (en) * | 1992-09-22 | 1994-05-31 | Rm Engineered Products, Inc. | Liveload assembly for maintaining torque on bolts |
US5355695A (en) | 1992-11-30 | 1994-10-18 | Mitsubishi Denki Kabushiki Kaisha | Refrigeration device using hydrofluorocarbon refrigerant |
US5395588A (en) * | 1992-12-14 | 1995-03-07 | Becton Dickinson And Company | Control of flow cytometer having vacuum fluidics |
US5439645A (en) | 1993-01-25 | 1995-08-08 | Coulter Corporation | Apparatus for automatically, selectively handling multiple, randomly associated hematological samples |
US5336620A (en) * | 1993-01-27 | 1994-08-09 | American Home Products Corporation | Process for the production of an anticoagulant composition |
IT1263831B (en) | 1993-01-29 | 1996-09-04 | Paolo Chiesi | MULTI-COMPONENT INCLUSION COMPLEXES WITH HIGH SOLUBILITY CONSTITUTED BY A BASIC-TYPE DRUG, AN ACID AND A CYCLODEXTRINE |
US5965454A (en) | 1993-02-03 | 1999-10-12 | Histaggen Incorporated | Automated histo-cytochemistry apparatus and encapsulation system for processing biological materials |
JP3129015B2 (en) | 1993-02-16 | 2001-01-29 | 株式会社日立製作所 | Inspection method and apparatus for dyed particles |
US5365595A (en) * | 1993-02-19 | 1994-11-15 | Motorola, Inc. | Sealed microphone assembly |
JPH06249857A (en) | 1993-02-26 | 1994-09-09 | Hitachi Ltd | Automatic analyzing device |
JPH06250906A (en) * | 1993-02-26 | 1994-09-09 | Fujitsu Ltd | Backup/recovery system for data developed in main storage device |
US5365614A (en) | 1993-03-22 | 1994-11-22 | The Orvis Company, Inc. | Sports vest |
US5446652A (en) | 1993-04-27 | 1995-08-29 | Ventana Systems, Inc. | Constraint knowledge in simulation modeling |
US5417213A (en) | 1993-06-07 | 1995-05-23 | Prince; Martin R. | Magnetic resonance arteriography with dynamic intravenous contrast agents |
US5587833A (en) * | 1993-07-09 | 1996-12-24 | Compucyte Corporation | Computerized microscope specimen encoder |
ES2259277T3 (en) | 1993-09-24 | 2006-10-01 | Abbott Laboratories | METHOD OF OPERATING AN AUTOMATIC ANALYTICAL SYSTEM OF CONTINUOUS RANDOM ACCESS ABLE TO SIMULTANEOUSLY MULTIPLE TESTS IN A PLURALITY OF LIQUID SAMPLES. |
US5416029A (en) | 1993-09-27 | 1995-05-16 | Shandon Inc. | System for identifying tissue samples |
US5439649A (en) | 1993-09-29 | 1995-08-08 | Biogenex Laboratories | Automated staining apparatus |
CA2132269C (en) | 1993-10-12 | 2000-02-01 | Rainer Hermann Doerrer | Interactive automated cytology method and system |
US5441580A (en) | 1993-10-15 | 1995-08-15 | Circle-Prosco, Inc. | Hydrophilic coatings for aluminum |
US5552087A (en) | 1993-11-15 | 1996-09-03 | Ventana Medical Systems, Inc. | High temperature evaporation inhibitor liquid |
US5487975A (en) * | 1993-11-15 | 1996-01-30 | Ventana Medical Systems, Inc. | Biotin/avidin formulation |
US5432056A (en) | 1993-11-15 | 1995-07-11 | Ventana Medical Systems, Inc. | Bisulfite-based tissue fixative |
US5733528A (en) | 1993-12-03 | 1998-03-31 | Dibra S.P.A. | Paramagnetic chelates for nuclear magnetic resonance diagnosis |
US6632598B1 (en) | 1994-03-11 | 2003-10-14 | Biogenex Laboratories | Deparaffinization compositions and methods for their use |
US6451551B1 (en) | 1994-03-11 | 2002-09-17 | Biogenex Laboratories | Releasing embedding media from tissue specimens |
US5930461A (en) | 1994-03-24 | 1999-07-27 | Bernstein; Steven A. | Method and apparatus for automated tissue assay |
US5582814A (en) | 1994-04-15 | 1996-12-10 | Metasyn, Inc. | 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging |
JPH10500310A (en) * | 1994-05-19 | 1998-01-13 | ダコ アクティーゼルスカブ | PNA probes for the detection of Neisseria gonorrhoeae and Chlamydia trachomatis |
IT1269839B (en) | 1994-05-26 | 1997-04-15 | Bracco Spa | CONJUGATES OF BILIARY ACIDS, THEIR DERIVATIVES WITH METALLIC COMPLEXES AND RELATED USES |
US6387326B1 (en) | 1994-07-19 | 2002-05-14 | Fisher Scientific Company L.L.C. | Automated slide staining system and method thereof |
US5431455A (en) | 1994-08-05 | 1995-07-11 | Seely; Stanley W. | Recreational vehicle sewer hose containment assembly |
US5946221A (en) * | 1994-09-07 | 1999-08-31 | American Auto-Matrix, Inc. | Method and system for maintaining a desired air flow through a fume hood |
WO1996009598A1 (en) * | 1994-09-20 | 1996-03-28 | Neopath, Inc. | Cytological slide scoring apparatus |
US6097995A (en) | 1994-11-30 | 2000-08-01 | Chemmist Limited Partnership | Hazardous materials and waste reduction management system |
KR100235345B1 (en) | 1994-12-29 | 1999-12-15 | 전주범 | Moving picture estimation apparatus and method in divided region |
US5578270A (en) * | 1995-03-24 | 1996-11-26 | Becton Dickinson And Company | System for nucleic acid based diagnostic assay |
GB9506312D0 (en) * | 1995-03-28 | 1995-05-17 | Medical Res Council | Improvements in or relating to sample processing |
US5676910A (en) | 1995-06-07 | 1997-10-14 | Alpha Scientific Corporation | Automatic blood film preparation device |
DE19525924A1 (en) | 1995-07-04 | 1997-01-09 | Schering Ag | Cascade polymer complexes, processes for their preparation and pharmaceutical compositions containing them |
JP3740167B2 (en) * | 1995-07-11 | 2006-02-01 | 双日株式会社 | Edible shrimp |
JP2901521B2 (en) | 1995-07-31 | 1999-06-07 | アロカ株式会社 | Biological tissue processing equipment |
US5963368A (en) | 1995-09-15 | 1999-10-05 | Accumed International, Inc. | Specimen management system |
WO1997011914A1 (en) | 1995-09-27 | 1997-04-03 | Technicat, Inc. | Water treatment arrangement |
WO1997017406A1 (en) | 1995-11-06 | 1997-05-15 | M & J Bos Consultants Pty. Ltd. | Uv absorbing compositions |
US5888733A (en) * | 1995-11-16 | 1999-03-30 | Dako A/S | In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples |
NO954650D0 (en) * | 1995-11-17 | 1995-11-17 | Torstein Ljungmann | Color machine for staining tissue samples on slides |
KR0168189B1 (en) | 1995-12-01 | 1999-02-01 | 김광호 | Control method and apparatus for recognition of robot environment |
US5605444A (en) | 1995-12-26 | 1997-02-25 | Ingersoll-Dresser Pump Company | Pump impeller having separate offset inlet vanes |
AUPN762196A0 (en) | 1996-01-17 | 1996-02-08 | Australian Biomedical Corporation Limited | Specimen preparation apparatus |
US5888876A (en) * | 1996-04-09 | 1999-03-30 | Kabushiki Kaisha Toshiba | Deep trench filling method using silicon film deposition and silicon migration |
AU741049B2 (en) * | 1996-05-09 | 2001-11-22 | Life Technologies Corporation | Microplate thermal shift assay and apparatus for ligand development and multi-variable protein chemistry optimization |
US6509193B1 (en) * | 1996-05-20 | 2003-01-21 | Precision System Science Co., Ltd. | Method and apparatus for controlling magnetic particles by pipetting machine |
DE19621179C2 (en) | 1996-05-25 | 2000-09-07 | Nonnenmacher Klaus | Transport unit for samples |
US5723092A (en) * | 1996-06-28 | 1998-03-03 | Dpc Cirrus Inc. | Sample dilution system and dilution well insert therefor |
US5885529A (en) * | 1996-06-28 | 1999-03-23 | Dpc Cirrus, Inc. | Automated immunoassay analyzer |
DE19633436A1 (en) | 1996-08-20 | 1998-02-26 | Boehringer Mannheim Gmbh | Method for the detection of nucleic acids by determining the mass |
CA2237955A1 (en) * | 1996-09-18 | 1998-03-26 | Kabushiki Kaisha Tiyoda Seisakusho | Liquid treating apparatus for biological sample |
JPH1090145A (en) | 1996-09-18 | 1998-04-10 | Chiyoda Manufacturing Co Ltd | Rinse method by automatic staining apparatus for microscopic sample |
US5839091A (en) | 1996-10-07 | 1998-11-17 | Lab Vision Corporation | Method and apparatus for automatic tissue staining |
US6735531B2 (en) | 1996-10-07 | 2004-05-11 | Lab Vision Corporation | Method and apparatus for automatic tissue staining |
US5945341A (en) | 1996-10-21 | 1999-08-31 | Bayer Corporation | System for the optical identification of coding on a diagnostic test strip |
US6110676A (en) | 1996-12-04 | 2000-08-29 | Boston Probes, Inc. | Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays |
US5968731A (en) * | 1996-12-10 | 1999-10-19 | The Regents Of The University Of California | Apparatus for automated testing of biological specimens |
US5937110A (en) * | 1996-12-20 | 1999-08-10 | Xerox Corporation | Parallel propagating embedded binary sequences for characterizing objects in N-dimensional address space |
US6327395B1 (en) | 1996-12-20 | 2001-12-04 | Xerox Parc | Glyph address carpet methods and apparatus for providing location information in a multidimensional address space |
US5958341A (en) | 1996-12-23 | 1999-09-28 | American Registry Of Pathology | Apparatus for efficient processing of tissue samples on slides |
US5948359A (en) | 1997-03-21 | 1999-09-07 | Biogenex Laboratories | Automated staining apparatus |
DE19712530A1 (en) | 1997-03-25 | 1998-10-01 | Boehringer Mannheim Gmbh | New monomer building blocks for labeling peptidic nucleic acids |
JP3428426B2 (en) * | 1997-03-26 | 2003-07-22 | 株式会社日立製作所 | Sample analysis system |
US5994071A (en) | 1997-04-04 | 1999-11-30 | Albany Medical College | Assessment of prostate cancer |
AU6898398A (en) * | 1997-04-08 | 1998-10-30 | Akzo Nobel N.V. | Method and apparatus for optimizing assay sequencing on a random access clinicallaboratory instrument |
US5900045A (en) * | 1997-04-18 | 1999-05-04 | Taiwan Semiconductor Manufacturing Co.Ltd. | Method and apparatus for eliminating air bubbles from a liquid dispensing line |
US5896486A (en) | 1997-05-01 | 1999-04-20 | Lucent Technologies Inc. | Mass splice tray for optical fibers |
DK0881228T3 (en) | 1997-05-30 | 2005-12-19 | Pna Diagnostics As | 2- or 3-dimensional geometric structures of peptide nucleic acids |
US6420916B1 (en) | 1997-08-05 | 2002-07-16 | Rockwell Collins, Inc. | Phase locked loop filter utilizing a tuned filter |
US20050135972A1 (en) * | 1997-08-11 | 2005-06-23 | Ventana Medical Systems, Inc. | Method and apparatus for modifying pressure within a fluid dispenser |
US8137619B2 (en) * | 1997-08-11 | 2012-03-20 | Ventana Medical Systems, Inc. | Memory management method and apparatus for automated biological reaction system |
US6045759A (en) | 1997-08-11 | 2000-04-04 | Ventana Medical Systems | Fluid dispenser |
US6093574A (en) | 1997-08-11 | 2000-07-25 | Ventana Medical Systems | Method and apparatus for rinsing a microscope slide |
US20020110494A1 (en) | 2000-01-14 | 2002-08-15 | Ventana Medical Systems, Inc. | Method and apparatus for modifying pressure within a fluid dispenser |
US6192945B1 (en) * | 1997-08-11 | 2001-02-27 | Ventana Medical Systems, Inc. | Fluid dispenser |
US6838051B2 (en) * | 1999-05-03 | 2005-01-04 | Ljl Biosystems, Inc. | Integrated sample-processing system |
US6486947B2 (en) | 1998-07-22 | 2002-11-26 | Ljl Biosystems, Inc. | Devices and methods for sample analysis |
NO306357B1 (en) * | 1997-10-16 | 1999-10-25 | Torstein Ljungmann | Color machine for preparation of tissue samples placed on slides |
DE19849591C2 (en) * | 1997-10-27 | 2001-07-19 | Hitachi Ltd | Automatic analyzer |
US6444170B1 (en) | 1997-12-17 | 2002-09-03 | Microm Laborgeräte GmbH | Apparatus for the treatment for specimens |
CA2315809C (en) | 1997-12-23 | 2014-06-03 | Dako A/S | Cartridge device for processing a sample mounted on a surface of a support member |
US6358682B1 (en) | 1998-01-26 | 2002-03-19 | Ventana Medical Systems, Inc. | Method and kit for the prognostication of breast cancer |
US6699710B1 (en) * | 1998-02-25 | 2004-03-02 | The United States Of America As Represented By The Department Of Health And Human Services | Tumor tissue microarrays for rapid molecular profiling |
US6855559B1 (en) | 1998-09-03 | 2005-02-15 | Ventana Medical Systems, Inc. | Removal of embedding media from biological samples and cell conditioning on automated staining instruments |
US6405609B1 (en) * | 1998-02-27 | 2002-06-18 | Ventana Medical Systems, Inc. | System and method of aspirating and dispensing reagent |
US6096271A (en) | 1998-02-27 | 2000-08-01 | Cytologix Corporation | Random access slide stainer with liquid waste segregation |
US6183693B1 (en) * | 1998-02-27 | 2001-02-06 | Cytologix Corporation | Random access slide stainer with independent slide heating regulation |
US6248590B1 (en) | 1998-02-27 | 2001-06-19 | Cytomation, Inc. | Method and apparatus for flow cytometry |
US6582962B1 (en) | 1998-02-27 | 2003-06-24 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
US7396508B1 (en) | 2000-07-12 | 2008-07-08 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
JP3847559B2 (en) | 1998-02-27 | 2006-11-22 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | Automated molecular pathology device with independent slide heater |
WO1999049295A1 (en) | 1998-03-24 | 1999-09-30 | Biogenex Laboratories | Automated staining apparatus |
US6495106B1 (en) | 1998-03-24 | 2002-12-17 | Biogenex Laboratories | Automated staining apparatus |
WO1999051015A1 (en) * | 1998-03-31 | 1999-10-07 | British Telecommunications Public Limited Company | Computer telephony integration |
US6395562B1 (en) | 1998-04-22 | 2002-05-28 | The Regents Of The University Of California | Diagnostic microarray apparatus |
EP1073767B1 (en) | 1998-04-29 | 2009-11-25 | Boston Probes, Inc. | Methods, kits and compositions for detecting and quantitating target sequences |
US6287772B1 (en) | 1998-04-29 | 2001-09-11 | Boston Probes, Inc. | Methods, kits and compositions for detecting and quantitating target sequences |
ATE363339T1 (en) * | 1998-05-01 | 2007-06-15 | Gen Probe Inc | STIRRING DEVICE FOR THE FLUID CONTENTS OF A CONTAINER |
EP1078098A1 (en) | 1998-05-04 | 2001-02-28 | Dako A/S | Method and probes for the detection of chromosome aberrations |
EP1078257A4 (en) * | 1998-05-09 | 2007-07-18 | Iconisys Inc | Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis |
JPH11326155A (en) | 1998-05-20 | 1999-11-26 | Hitachi Ltd | Cell fractionating device |
AU4696399A (en) * | 1998-06-22 | 2000-01-10 | Regents Of The University Of California, The | Composition and methods for evaluating an organism's response to alcohol |
AUPP441798A0 (en) | 1998-06-30 | 1998-07-23 | Australian Biomedical Corporation Limited | Laboratory sampling probe positioning apparatus |
JP2002520578A (en) | 1998-07-13 | 2002-07-09 | バイオジェネックス ラボラトリーズ | Reagent bottles for automated process equipment |
WO2000009650A1 (en) * | 1998-08-10 | 2000-02-24 | Genomic Solutions, Inc. | A thermal/fluidic cycling device for the purpose of nucleic acid hybridization |
US6196979B1 (en) | 1998-08-24 | 2001-03-06 | Burstein Technologies, Inc. | Cassette and applicator for biological and chemical sample collection |
FR2782800B1 (en) * | 1998-09-01 | 2000-10-20 | Abx Sa | DEVICE FOR THE AUTOMATIC PREPARATION OF BLOOD SPREADS ON BLADES |
US6414133B1 (en) | 1998-10-13 | 2002-07-02 | Ventana Medical Systems, Inc. | Multiple fusion probes |
US6413780B1 (en) | 1998-10-14 | 2002-07-02 | Abbott Laboratories | Structure and method for performing a determination of an item of interest in a sample |
EP1003121A3 (en) | 1998-10-30 | 2001-10-04 | Becton Dickinson and Company | Medication and specimen management system |
US6110425A (en) | 1998-12-03 | 2000-08-29 | Coulter International Corp. | Blood smear slide outloader |
US20010055799A1 (en) | 1998-12-15 | 2001-12-27 | David Baunoch | Method and apparatus for automated reprocessing of tissue samples |
US6890759B2 (en) | 1998-12-30 | 2005-05-10 | Becton, Dickinson And Company | System and method for universal identification of biological samples |
US6544798B1 (en) * | 1999-02-26 | 2003-04-08 | Ventana Medical Systems, Inc. | Removal of embedding media from biological samples and cell conditioning on automated staining instruments |
US20020017854A1 (en) | 1999-03-08 | 2002-02-14 | Paul Von Allmen | Electron emissive surface and method of use |
US6548822B1 (en) * | 1999-12-30 | 2003-04-15 | Curators Of University Of Missouri | Method of performing analytical services |
US20020176801A1 (en) | 1999-03-23 | 2002-11-28 | Giebeler Robert H. | Fluid delivery and analysis systems |
US6142292A (en) | 1999-03-23 | 2000-11-07 | Fmc Corporation | Method and apparatus to prevent a bearing from rotating in a bearing housing |
US6281004B1 (en) | 1999-04-14 | 2001-08-28 | Cytologix Corporation | Quality control for cytochemical assays |
DE19918442B4 (en) | 1999-04-23 | 2005-04-14 | Leica Microsystems Nussloch Gmbh | Staining automat for staining objects for microscopic examination |
US6192970B1 (en) | 1999-04-28 | 2001-02-27 | Rivindra V. Tilak | Independently positioned graphite inserts in annular metal casting molds |
ES2160486B1 (en) | 1999-04-30 | 2002-05-16 | Consejo Superior Investigacion | Cell for holding of materials designated for transplants consists of a pressurized container housing the holder of the biological sample in physiological fluid |
US6335208B1 (en) * | 1999-05-10 | 2002-01-01 | Intersil Americas Inc. | Laser decapsulation method |
AU5870100A (en) | 1999-06-11 | 2001-01-02 | Foxboro Company, The | Methods and apparatus for control using control devices that provide a virtual machine environment and that communicate via an ip network |
US6104483A (en) | 1999-06-18 | 2000-08-15 | Lockheed Martin Tactical Defense Systems, Inc. | Optical flow cell with references flange |
EP1192464A1 (en) | 1999-06-29 | 2002-04-03 | Dako A/S | Benzoate buffers for zone electrophoresis and immunofixation |
EP1192465A1 (en) | 1999-06-29 | 2002-04-03 | Dako A/S | Detection using dendrimers bearing labels and probes |
AU6079500A (en) | 1999-07-08 | 2001-01-30 | Lee Angros | Antigen recovery and/or staining apparatus and method |
AU6093400A (en) * | 1999-07-13 | 2001-01-30 | Chromavision Medical Systems, Inc. | Automated detection of objects in a biological sample |
DE19933153A1 (en) * | 1999-07-20 | 2001-02-08 | Byk Gulden Lomberg Chem Fab | Device for processing analytes on solid phases |
JP2003520945A (en) | 1999-07-21 | 2003-07-08 | ダコ エー エス | Method of controlling temperature of sample in or on solid support member |
WO2001020321A2 (en) | 1999-09-16 | 2001-03-22 | Shofner Engineering Associates, Inc. | Conditioning and testing cotton fiber |
US6403036B1 (en) | 1999-09-29 | 2002-06-11 | Ventana Medical Systems, Inc. | Temperature monitoring system for an automated biological reaction apparatus |
US6403931B1 (en) | 1999-10-07 | 2002-06-11 | Ventana Medical Systems, Inc. | Slide heater calibrator and temperature converter apparatus and method |
EP1218547A4 (en) | 1999-10-15 | 2005-04-20 | Ventana Med Syst Inc | Method of detecting single gene copies in-situ |
ES2283347T3 (en) * | 1999-10-29 | 2007-11-01 | Cytyc Corporation | APPARATUS AND PROCEDURE TO VERIFY THE LOCATION OF AREAS OF INTEREST WITHIN A SAMPLE IN AN IMAGE FORMATION SYSTEM. |
FI116487B (en) | 1999-11-15 | 2005-11-30 | Thermo Electron Oy | Apparatus and method for the treatment of laboratory test tubes |
WO2001051928A1 (en) | 2000-01-12 | 2001-07-19 | Ventana Medical Systems, Inc. | Method for quantitating a protein by image analysis |
US6746851B1 (en) | 2000-01-14 | 2004-06-08 | Lab Vision Corporation | Method for automated staining of specimen slides |
DE10002803A1 (en) | 2000-01-24 | 2001-08-02 | Conbio Lizenzverwertungsgesell | System for the internal qualitative and quantitative validation of marker indices |
AU2001236726A1 (en) | 2000-02-08 | 2001-08-20 | The Regents Of The University Of Michigan | Protein separation and display |
US6452672B1 (en) | 2000-03-10 | 2002-09-17 | Wyatt Technology Corporation | Self cleaning optical flow cell |
DE10012465A1 (en) | 2000-03-15 | 2001-10-11 | Jagenberg Papiertech Gmbh | Assembly for coating the surfaces of a paper/cardboard web at the papermaking machine has a setting unit to act on the press rollers against their springs to give a low linear pressure in the press gap |
EP1284823A1 (en) | 2000-03-16 | 2003-02-26 | Biogenex Laboratories | Automated specimen processing apparatus with fluid detection |
US20030100043A1 (en) | 2000-03-24 | 2003-05-29 | Biogenex Laboratories, Inc. | Device and methods for automated specimen processing |
FR2806934B1 (en) | 2000-03-30 | 2003-04-18 | Eisenmann France Sarl | DEVICE FOR CONTROLLING A SURFACE TREATMENT INSTALLATION, PARTICULARLY FOR THE AUTOMOTIVE INDUSTRY |
US6503457B1 (en) | 2000-04-14 | 2003-01-07 | Discovery Partners International, Inc. | Container and method for high volume treatment of samples on solid supports |
US6615763B2 (en) | 2000-05-12 | 2003-09-09 | Innovative Science Limited | Printing on microscope slides and histology cassettes |
JP2003533682A (en) | 2000-05-15 | 2003-11-11 | テカン・トレーディング・アクチェンゲゼルシャフト | Bidirectional flow centrifugal microfluidic device |
GB0013619D0 (en) | 2000-06-06 | 2000-07-26 | Glaxo Group Ltd | Sample container |
US20030163031A1 (en) * | 2000-06-26 | 2003-08-28 | Adlabs, Inc. | Method and system for providing centralized anatomic pathology services |
US20020147512A1 (en) | 2000-07-25 | 2002-10-10 | Affymetrix, Inc. | System and method for management of microarray and laboratory information |
DE10041231A1 (en) | 2000-08-22 | 2002-03-07 | Leica Microsystems | Device for treating objects |
DE10041228B4 (en) * | 2000-08-22 | 2019-02-14 | Leica Biosystems Nussloch Gmbh | Device for the treatment of cytological or histological preparations |
DE10041229A1 (en) * | 2000-08-22 | 2002-03-07 | Leica Microsystems | Handling apparatus for cytological or histological preparations has region which receives modular processing stations |
DE10041226A1 (en) | 2000-08-22 | 2002-03-07 | Leica Microsystems | Method for treatment of cytological and histological specimens, selects shortest paths for distributing specimens to group of treatment stations |
DE10041230A1 (en) | 2000-08-22 | 2002-03-07 | Leica Microsystems | Handling apparatus for cytological or histological preparations has feed stations and/or removal stations allocated to several processing stations |
US6735331B1 (en) * | 2000-09-05 | 2004-05-11 | Talia Technology Ltd. | Method and apparatus for early detection and classification of retinal pathologies |
EP1978110B1 (en) | 2000-09-06 | 2010-05-26 | Transnetyx, Inc. | Computer-based method and system for screening genomic DNA |
DE10052503A1 (en) | 2000-10-23 | 2002-04-25 | Leica Microsystems | Object treatment device has insert that reduces maximum fill height of container, whereby rack for carrying objects for immersion in container matches residual volume |
DE10052833A1 (en) * | 2000-10-24 | 2002-04-25 | Leica Microsystems | Laboratory assembly to dye cytological or histological preparations monitors reagents over extended period |
DE10052832A1 (en) | 2000-10-24 | 2002-04-25 | Leica Microsystems | Laboratory assembly treating cytological or histological preparations has series of identical treatment stations for use as required |
AU2002253796A1 (en) * | 2000-10-30 | 2002-08-28 | Robodesign International, Inc. | High capacity microarray dispensing |
US7113922B2 (en) | 2000-11-02 | 2006-09-26 | Living Naturally, Llc | Electronic inventory movement and control device |
US6844184B2 (en) * | 2000-11-08 | 2005-01-18 | Surface Logix, Inc. | Device for arraying biomolecules and for monitoring cell motility in real-time |
US20030215936A1 (en) * | 2000-12-13 | 2003-11-20 | Olli Kallioniemi | High-throughput tissue microarray technology and applications |
GB0030809D0 (en) | 2000-12-16 | 2001-01-31 | Schmidt Paul | Sample tracking systems |
EP1372121A4 (en) * | 2000-12-22 | 2004-06-09 | Arkray Inc | Measurement instrument |
JP4322430B2 (en) * | 2001-01-29 | 2009-09-02 | エスアイアイ・ナノテクノロジー株式会社 | Differential scanning calorimeter |
US6855925B2 (en) * | 2001-02-14 | 2005-02-15 | Picoliter Inc. | Methods, devices, and systems using acoustic ejection for depositing fluid droplets on a sample surface for analysis |
DE10115065A1 (en) | 2001-03-27 | 2002-10-02 | Leica Microsystems | Method and device for printing on cassettes or slides for histological preparations |
EP1248170B1 (en) * | 2001-04-05 | 2009-09-16 | INPECO IP Ltd. | Method for the management of workcell systems based on an automation management system |
US20030003537A1 (en) | 2001-04-30 | 2003-01-02 | Ventana Medical Systems, Inc. | Method and composition of matter for enhancing staining of microorganisms |
JP3603278B2 (en) * | 2001-09-06 | 2004-12-22 | 理学電機工業株式会社 | X-ray fluorescence analysis system and program used therefor |
DE10144042B4 (en) | 2001-09-07 | 2006-04-13 | Leica Microsystems Nussloch Gmbh | Processing device for dyeing and covering slides |
JP5193408B2 (en) * | 2001-09-13 | 2013-05-08 | ベックマン コールター, インコーポレイテッド | Automatic analyzer |
US20030162221A1 (en) | 2001-09-21 | 2003-08-28 | Gary Bader | Yeast proteome analysis |
WO2003029845A2 (en) | 2001-10-01 | 2003-04-10 | Vision Biosystems Limited | Histological tissue specimen treatment |
ATE365909T1 (en) * | 2001-10-19 | 2007-07-15 | Monogen Inc | APPARATUS AND METHOD FOR MIXING SAMPLES IN VESSELS |
KR100458148B1 (en) * | 2001-10-29 | 2004-11-26 | 포라 가세이 고교 가부시키가이샤 | A skin analysis system |
US7270785B1 (en) | 2001-11-02 | 2007-09-18 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having fixed slide platforms |
DE10154843A1 (en) | 2001-11-08 | 2003-05-28 | Microm Int Gmbh | Method and device for labeling slides for microtomized tissue samples and their processing |
DE20118271U1 (en) * | 2001-11-09 | 2002-02-14 | Rehau Ag & Co | Windshield wiper fluid reservoir |
AU2002361618A1 (en) | 2001-11-13 | 2003-05-26 | Chromavision Medical Systems, Inc. | A system for tracking biological samples |
US6998270B2 (en) | 2001-11-26 | 2006-02-14 | Lab Vision Corporation | Automated tissue staining system and reagent container |
US20040033163A1 (en) * | 2001-11-26 | 2004-02-19 | Lab Vision Corporation | Automated tissue staining system and reagent container |
US7005110B2 (en) | 2001-12-20 | 2006-02-28 | Ventana Medical Systems, Inc. | Method and apparatus for preparing tissue samples for sectioning |
US8449822B2 (en) * | 2002-01-18 | 2013-05-28 | Sysmex Corporation | Smear preparing apparatuses and methods of preparing sample smears |
US7378058B2 (en) * | 2002-01-30 | 2008-05-27 | Ventana Medical Systems, Inc. | Method and apparatus for modifying pressure within a fluid dispenser |
US7468161B2 (en) * | 2002-04-15 | 2008-12-23 | Ventana Medical Systems, Inc. | Automated high volume slide processing system |
JP4299150B2 (en) * | 2002-04-15 | 2009-07-22 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | System for automatically staining large-capacity slides |
US20030200111A1 (en) | 2002-04-19 | 2003-10-23 | Salim Damji | Process for determining optimal packaging and shipping of goods |
JP4091599B2 (en) | 2002-04-26 | 2008-05-28 | ヴェンタナ メディカル システムズ インコーポレイテッド | Automated molecular pathology device with fixed slide platform |
WO2003098426A1 (en) | 2002-05-13 | 2003-11-27 | Scinomix | Automated processing system and method of using same |
US6800249B2 (en) | 2002-06-14 | 2004-10-05 | Chromavision Medical Systems, Inc. | Automated slide staining apparatus |
WO2004001390A1 (en) | 2002-06-20 | 2003-12-31 | Vision Biosystems Limited | Biological reaction apparatus with draining mechanism |
DE20210451U1 (en) * | 2002-07-05 | 2002-10-17 | Leica Microsystems | Drive for a device for coloring objects |
EP1313262A1 (en) * | 2002-07-30 | 2003-05-21 | Agilent Technologies Inc. a Delaware Corporation | Integrating different naming conventions into a network management system |
US6832904B2 (en) | 2002-08-15 | 2004-12-21 | Wellman, Inc. | Apparatus for cooling and finishing melt-spun filaments |
US6872901B2 (en) * | 2002-11-21 | 2005-03-29 | Exon Science Inc. | Automatic actuation of device according to UV intensity |
US7015831B2 (en) | 2002-12-17 | 2006-03-21 | Evolution Robotics, Inc. | Systems and methods for incrementally updating a pose of a mobile device calculated by visual simultaneous localization and mapping techniques |
US20040122708A1 (en) | 2002-12-18 | 2004-06-24 | Avinash Gopal B. | Medical data analysis method and apparatus incorporating in vitro test data |
US7584019B2 (en) * | 2003-12-15 | 2009-09-01 | Dako Denmark A/S | Systems and methods for the automated pre-treatment and processing of biological samples |
US7850912B2 (en) | 2003-05-14 | 2010-12-14 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
AU2003287924B2 (en) | 2002-12-20 | 2010-03-04 | Dako Denmark A/S | An automated sample processing apparatus and a method of automated treating of samples and use of such apparatus |
US7875245B2 (en) | 2003-05-14 | 2011-01-25 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
US7648678B2 (en) | 2002-12-20 | 2010-01-19 | Dako Denmark A/S | Method and system for pretreatment of tissue slides |
AU2003900780A0 (en) | 2003-02-21 | 2003-03-13 | Vision Biosystems Limited | Analysis system and procedure |
AU2003900810A0 (en) | 2003-02-24 | 2003-03-13 | Vision Biosystems Limited | Method of scheduling |
JP2004325117A (en) | 2003-04-22 | 2004-11-18 | Olympus Corp | Liquid dispensing apparatus and method of washing dispensing head |
US20060073074A1 (en) * | 2004-10-06 | 2006-04-06 | Lars Winther | Enhanced sample processing system and methods of biological slide processing |
US20040260721A1 (en) | 2003-06-20 | 2004-12-23 | Marie Coffin | Methods and systems for creation of a coherence database |
US8719053B2 (en) * | 2003-07-17 | 2014-05-06 | Ventana Medical Systems, Inc. | Laboratory instrumentation information management and control network |
US7860727B2 (en) | 2003-07-17 | 2010-12-28 | Ventana Medical Systems, Inc. | Laboratory instrumentation information management and control network |
US9518899B2 (en) * | 2003-08-11 | 2016-12-13 | Sakura Finetek U.S.A., Inc. | Automated reagent dispensing system and method of operation |
EP2489437A1 (en) * | 2003-09-09 | 2012-08-22 | BioGenex Laboratories | Sample processing system |
DE10342264C5 (en) | 2003-09-12 | 2012-10-31 | Leica Biosystems Nussloch Gmbh | System for uniquely assigning histological cassettes and slides |
EP1673608A4 (en) | 2003-09-29 | 2008-05-07 | Vision Biosystems Ltd | System and method for histological tissue specimen processing |
US7142852B2 (en) | 2003-11-13 | 2006-11-28 | Motorola, Inc. | Method and gateway for controlling call routing |
EP1733240A4 (en) | 2004-03-02 | 2007-08-22 | Dako Denmark As | Reagent delivery system, dispensing device and container for a biological staining apparatus |
DE202004006265U1 (en) | 2004-04-21 | 2004-06-17 | Leica Microsystems Nussloch Gmbh | Microtem for the production of thin sections |
JP4482371B2 (en) * | 2004-05-12 | 2010-06-16 | シスメックス株式会社 | Clinical specimen processing system |
JP4152351B2 (en) * | 2004-06-17 | 2008-09-17 | シスメックス株式会社 | Clinical specimen processing apparatus and clinical specimen processing system |
EP1771716A4 (en) | 2004-06-29 | 2012-04-25 | Dako Denmark As | Method of pre-treatment and staining of and support device for a biological sample |
EP1612536A3 (en) * | 2004-06-29 | 2007-03-07 | Sysmex Corporation | Clinical specimen processsing apparatus |
US7867443B2 (en) * | 2004-07-23 | 2011-01-11 | Dako Denmark A/S | Method and apparatus for automated pre-treatment and processing of biological samples |
CN1753432A (en) * | 2004-09-22 | 2006-03-29 | 国际商业机器公司 | Method and system for implementing personalized incoming notifying and terminal apparatus |
US20060084088A1 (en) | 2004-10-15 | 2006-04-20 | Schultz Emily R | Tracking biological samples and their processing history |
JP4840763B2 (en) * | 2006-01-18 | 2011-12-21 | セイコーインスツル株式会社 | Automatic thin section preparation apparatus and automatic thin section preparation apparatus |
ATE529732T1 (en) * | 2006-10-30 | 2011-11-15 | Ventana Med Syst Inc | THIN FILM APPARATUS AND METHOD |
-
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- 2003-12-08 US US10/731,316 patent/US7648678B2/en active Active
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