CA2518862A1 - Apparatus, method and assembly for delivery of intra-bronchial devices - Google Patents

Apparatus, method and assembly for delivery of intra-bronchial devices Download PDF

Info

Publication number
CA2518862A1
CA2518862A1 CA002518862A CA2518862A CA2518862A1 CA 2518862 A1 CA2518862 A1 CA 2518862A1 CA 002518862 A CA002518862 A CA 002518862A CA 2518862 A CA2518862 A CA 2518862A CA 2518862 A1 CA2518862 A1 CA 2518862A1
Authority
CA
Canada
Prior art keywords
intra
bronchial device
deployment
loading tool
bronchial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002518862A
Other languages
French (fr)
Inventor
Lucas S. Gordon
James M. Kutsko
David H. Dillard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Spiration Inc
Original Assignee
Spiration Inc.
Lucas S. Gordon
James M. Kutsko
David H. Dillard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spiration Inc., Lucas S. Gordon, James M. Kutsko, David H. Dillard filed Critical Spiration Inc.
Publication of CA2518862A1 publication Critical patent/CA2518862A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/087—Particle radiation, e.g. electron-beam, alpha or beta radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12104—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in an air passage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
    • A61B17/12172—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/20—Gaseous substances, e.g. vapours
    • A61L2/206—Ethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205—Introduction devices

Abstract

An assembly delivers an intra-bronchial device (250) into an air passageway.
The assembly includes a delivery catheter having a deployment lumen (122) with a distal end (130) configured to receive the intra-bronchial device (250) in a delivery configuration, and configured to be passed down a trachea and advanced to a location for deployment of the intra-bronchial device (250) in an air passageway (48) of a lung. The assembly is further configured to deploy the intra-bronchial device (250) by retracting a portion of the deployment catheter (120). The assembly further includes a bronchial device supply tool associated with the distal end (130) of the deployment catheter. The supply tool is configured to carry the intra-bronchial device (250) in a storage configuration and to load the intra-bronchial device (250) in a delivery configuration into the deployment lumen (122) of distal end (130) of the deployment catheter (120). The supply tool is also configured to carry the intra-bronchial device (250) in an expanded storage configuration. An embodiment of the supply tool includes a storage cavity, a delivery portion, and a tapered configuration.

Description

APPARATUS, METHOD AND ASSEMBLY FOR DELIVERY OF
INTRA-BRONCHIAL DEVICES
Baclcground [0001] Advances in medicine are providing improved intra-bronchial devices for delivery to portions of the respiratory system, particularly the lungs and bronchi. The intra-bronchial devices typically are delivered into the respiratory system by deployment from a catheter placed into the respiratory system through a worl~ing channel of a bronchoscope.
[0002] Storage, transportation, and placing the devices in a delivery configuration present unique problems not previously addressed in the medical community. The devices are small, fragile, and difficult to handle and store. As a result, it may be difficult to physically select a desired device, load the device into a catheter, and deliver the device to the intended location in a respiratory system without a risl~ of compromising the device.
Ful-thermore, the devices may require sterilization and isolation from contaminates before implantation, and may have features that interfere with delivery, such as anchors. Another factor is that several different sizes of devices must be available during a procedure because the diameter of the air passageways varies, continuously becoming smaller in the distal direction.
[0003] Intra-bronchial devices may be used for a variety of therapeutic objectives.
For example, these objectives may include, but are not limited to, treatment of CllTOlllc obstructive puhnonary disease (COPD) by lung volume reduction as described in US Patent No. 6,258,100, METHOD OF REDUCING LUNG SIDE, and US Patent No. 6,293,951, LUNG REDUCTION DEVICE, SYSTEM, AND METHOD; and provision of a therapeutic agent as described in US Patent Application Publication No. 2003-0158515 A1, "DEVICE

AGENT," all of which are commonly owned by the assignee of this document.
Intra-bronchial devices are presently available with several different types of structures, including devices that preclude air flow in both directions, preclude air flow in one direction as described in the '951 patent, or do not preclude air flow at all as described in US Patent Application Publication No. 2003-0154988 A1.
[0004] Furthermore, infra-bronchial devices may include aalchoring members or other features that may be advantageously served by appropriate storage. For example, devices with anchoring members are described in US Patent Application Publication No.
2002-0050648 Al, REMOVABLE LUNG REDUCTION DEVICES, SYSTEMS, AND
METHODS; US Patent Application Publication No. 2003-0181922 Al, REMOVABLE
ANCHORED LUNG VOLUME REDUCTION DEVICES AND METHODS; and US Patent Application Publication No. 2003-0216769 Al, REMOVABLE ANCHORED LUNG
VOLUME REDUCTION DEVICES AND METHODS, hereafter collectively referred to as "the anchored device applications." The anchored device applications are all connnonly owned by the assignee of the present invention. Obstructing members, anchoring members, and other features of infra-bronchial devices are typically collapsed or compressed into a delivery configuration to fit into a deployment channel, such as a catheter lumen, for delivery into an air passageway. However, the obstructing members, anchoring members, or other features may require storage in a configuration different than their delivery configuration to maintain functionality. For example, elasticity of an infra-bronchial device obstructing member or elasticity of anchoring members may be degraded by storage in a delivery conft guration.
[0005] W addition, an infra-bronclual device may include a medicant or a therapeutic agent that requires special storage considerations, or that does not tolerate physical handling that might be required to place it in a delivery configuration or load it into a deployment lumen. For example, see US Patent Application Publication No.

Al, 1NTRA-BRONCHIAL DEVICE THAT PROVIDES A MEDICANT 1NTRA-BRONCHIALLY TO THE PATIENT; and U.S. Patent Application Publication No. 2003-0158515 Al, DEVICE AND METHOD FOR 1NTRA-BRONCHIAL PROVISION OF A
THERAPEUTIC AGENT, all of which are cormnonly owned by the assignee of the present invention.
[0006] Also, treatment involving infra-bronchial devices requires a provider to have different sizes of infra-bronchial devices readily available during a procedure to match the different diameters of air passageways. This is because the air passageways into which the infra-bronchial devices may be deployed branch out, much lilce the roots of a tree wherein each branch is progressively smaller. No single infra-bronchial device is presently able to fit an entire range of internal air passageway diameters; therefore, several different sizes of infra-bronchial devices should be available when treating a patient.
[0007] In view of the foregoing, there is a continuing need for an improved device, assembly, and method for storage, transportation, delivery, and implantation of intra-bronchial devices. The present invention is directed to such a device, assembly, and method.
Summary of the Invention [0008] The invention provides an assembly for delivering an infra-bronchial device into an air passageway. The assembly includes a delivery catheter having a deployment lumen with a distal end arranged to receive the infra-bronchial device in a delivery configuration, and arranged to be passed down a trachea and advanced to a location in an air passageway for deployment of the intTa-bronchial device, and to deploy the intra-bronchial device by retracting the deployment catheter. The assembly further includes a bronchial device supply tool associated with the distal end, and arranged to carry the intra-bronchial device in a storage configuration and to load the infra-bronchial device in a delivery configuration into the deployment lumen of distal end. The assembly still further provides the infra-bronchial device carried in the supply tool in a storage configuration. The delivery catheter may include a deployment catheter having a deployment lumen, and a stabilization member arranged to be carried in the deploynent lumen and to stabilize the infra-bronchial device at the location during retraction of the distal end.
The supply tool may include a storage portion, a delivery portion, and a configuration-changing portion coupled between the storage portion and the delivery portion.
[0009] Another embodiment of the invention provides an assembly for delivering an infra-bronchial device into an air passageway. The assembly includes a delivery catheter having a distal sheath arranged to receive the infra-bronchial device in a delivery configuration and to deploy the infra-bronchial device by unsheathing, the distal sheath being further arranged to be passed down a trachea and advanced to a location in an air passageway for deployment of the infra-bronchial device. The assembly also includes a bronchial device supply tool removably coupled to the distal end and arranged to carry the infra-bronchial device in a storage configuration, and to load the infra-bronchial device in a delivery configuration into the sheath, and the infra-bronchial device carried in the supply tool in a storage configuration. The delivery catheter may include a stabilization member arranged to be carried in the delivery catheter and to stabilize the infra-bronchial device at the location during unsheathing. The supply tool may include a storage portion, a delivery portion, and a configuration-changing portion coupled between the storage portion and the delivery portion.
[0010] A further embodiment of the invention provides a method of delivering an infra-bronchial device into an air passageway. The method includes the steps of moving the infra-bronchial device from a storage configuration to a delivery configuration, loading the infra-bronchial device in a delivery configuration into a distal end of a deployment lumen, advancing the distal end down a trachea to a location in an air passageway, stabilizing the infra-bronchial device at the location, and retracting the distal end to deploy the intra-bronchial device. The loading step may include the further steps of moving the intra-bronchial device into the distal end from a supply tool associated with the distal end, and disassociating the supply tool from the distal end.
[0011] A still further embodiment of the invention provides a method of delivering an infra-bronchial device into an air passageway. The method includes the steps of moving the infra-bronchial device from a storage configuration to a delivery configuration and loading the infra-bronchial device in a delivery configuration into a sheath arranged for deployment of the infra-bronchial device by unsheathing. The method also includes advancing the sheathed infra-bronchial device down a trachea to a location in an air passageway, and stabilizing the infra-bronchial device at the location while unsheathing the infra-bronchial device.
[0012] Y'et a still further embodiment of the invention provides an assembly for delivering an infra-bronchial device into an air passageway. The assembly includes means for advancing the infra-bronchial device in a sheathed delivery configuration down a trachea to a location in an air passageway and for delivering the infra-bronchial device by unsheathing, means for stabilizing the infra-bronchial device at the location while unsheathing the intra-bronchial device, and means associated with the sheath means for carrying the intra-bronchial device in a storage configuration, and for loading the infra-bronchial device in a delivery configuration into the sheath means.
[0013] Another embodiment of the invention provides a delivery catheter for delivering an infra-bronchial device into an air passageway. The delivery catheter includes a deployment catheter having a deployment lumen with a distal end arranged to receive the infra-bronchial device in a delivery configuration, the distal end being further arranged to be passed down a trachea and advanced into an air passageway to a location for deployment of the infra-bronchial device. The delivery catheter also includes a stabilization member arranged to be carried in the deployment lumen and to stabilize the infra-bronchial device at the location during retraction of the distal end, the deployment catheter and the stabilization member being longitudinally moveable relative to each other such that retracting the deployment catheter deploys the infra-bronchial device. The delivery catheter may include an infra-bronchial device carried in the distal end in a delivery configuration.
The delivery catheter may include an actuator arranged to allow an operator to maintain the stabilization member in a position while retracting the deployment catheter. The delivery catheter may be sterilizable.
[0014] A further embodiment of the invention provides a method of delivering an infra-bronchial device into an air passageway. The method includes the steps of advancing a sheathed infra-bronchial device down a trachea to a location in an air passageway for deployment, stabilizing the infra-bronchial device at the location, and retracting the sheath to deploy the stabilized infra-bronchial device. The method may include the fuuther step of loading the infra-bronchial device in a delivery configuration into a sheath.
[0015] A still further embodiment of the invention provides a delivery catheter for delivering an infra-bronchial device into an air passageway. The delivery catheter includes a strain- relief catheter having a lumen, arid a deployment catheter at least partially carried within the strain-relief catheter lumen and having a deployment lumen with a distal end arranged to receive the infra-bronchial device in a delivery conFguration, the distal end being further arranged to be passed down a trachea and advanced into an air passageway to a location for deployment of the intra-bronchial device. The delivery catheter further includes a stabilization member arranged to be carried with the deployment lumen and to stabilize the received infra-bronchial device at the location during retraction of the distal end, the stabilization member and the strain-relief catheter being coupled such that one is not longitudinally moveable relative to the other, and the deployment catheter and the stabilization member being longitudinally moveable relative to each other such that retracting the deployment catheter deploys the infra-bronchial device. The delivery catheter may include an infra-bronchial device in a delivery configuration carried in the distal end. The delivery catheter may include an actuator having a first portion coupling the stabilization member and the strain-relief catheter and allowing an operator to maintain the stabilization member in a position, and a second portion allowing the operator to retract the deployment catheter.
[0016] Another embodiment of the invention provides a delivery catheter for delivering an infra-bronchial device into an air passageway. The assembly including a delivery catheter having a distal sheath arranged to receive the infra-bronchial device in a delivery configuration and to deploy the intra-bronchial device by unsheathing, the distal sheath being further arranged to be passed down a trachea and advanced to a location in an air passageway for deployment of the infra-bronchial device, and a stabilization member arranged to be carried in the delivery catheter and to stabilize the infra-bronchial device at the location during unsheathing. The delivery catheter may further include the infra-bronchial device carried in the distal sheath in a delivery configur ation.
[0017] Yet another embodiment of the invention provides a delivery catheter for delivering an infra-bronchial device into an air passageway. The delivery catheter includes sheathing means for receiving the infra-bronchial device in a delivery configuration and for delivering the infra-bronchial device by unsheathing, means for advancing the sheathed intra-bronchial device down a trachea to a location in an air passageway for deployment. The delivery catheter also includes means carried w1t11111 the advancing means for stabilizing the infra-bronchial device at the location while unsheathing the intra-bronchial device, the sheathing means and the stabilization means being longitudinally moveable relative to each other such that retracting the sheathing means unsheathes the infra-br onchial device at the location. The delivery catheter may further include an infra-bronchial device in a delivery configuration carried in the sheathing means.
[001] An embodiment of the invention provides an infra-bronchial device supply tool for supplying an infra-bronchial device in a delivery configuration to a deployment lumen. The supply tool including a storage portion arranged for carrying the infra-bronchial device in a storage configuration, and a delivery portion for loading the infra-bronchial device in a delivery configuration into a deployment lumen, and having an end configured for association with the deployment lumen. The supply tool also includes a configuration-changing portion coupled between the storage portion and the delivery portion, and arranged in cooperation with a pushing member for changing the infra-bronchial device from the storage configuration to the delivery configuration. The storage portion may be further arranged for carrying a plurality of sizes of infra-bronchial devices. The pushing member may be further arranged to move the infra-bronchial device a predetermined distance into the deployment lumen. The supply tool may be further arranged to allow sterilization of the infra-bronchial device carried therein. The sterilization may include ethylene oxide (Et0), electron beam radiation, or other suitable sterilization method. The supply tool may further include the infra-bronchial device in a storage configuration carried in the storage portion.
[0019) A further embodiment of the invention provides an infra-bronchial device supply tool for supplying an infra-bronchial device in a delivery configuration to a deployment lumen. The tool includes a storage portion arranged for carrying the intra-bronchial device in a storage configuration, a delivery portion arranged for loading the intra-bronchial device in a delivery configuration into the deployment lumen and having an end configured for association with the deployment lumen. The tool also includes a longitudinal GollflgllratlOn- changing portion coupled between the storage portion and the delivery portion, and arranged for changing the infra-bronchial device from the storage configuration to the delivery configuration as the infra-bronchial device is moved from the storage portion to the delivery portion, and a pushing member arranged for moving the infra-bronchial device from the storage portion to the delivery portion. The configuration-changing portion may include a narrowing passage between the storage portion and the delivery portion. The configuration-changing portion may include a passage having a continuously varying diameter. The configuration-changing portion may include a passage that, as the intra-bronchial device moves from the storage portion to the delivery portion, presents the intra-bronchial device with a continuously reducing diameter. The supply tool may further include a coupler that associates the delivery portion and the deployment lumen for loading the intra-bronchial device. The pushing member may be further arranged to move the infra-bronchial device a predetermined distance into the deployment lumen.
[0020] Another embodiment includes a method of supplying an infra-bronchial device in a delivery configuration to a deployment lumen. The method includes the steps of carrying the infra-bronchial device in a storage configuration, changing the infra-bronchial device from the storage configuration to a delivery configuration, and loading the intra-bronchial device in a delivery configuration into the deployment lumen. The changing step may include the further step of moving the infra-bronchial device through a narrowing passage. The loading step may include the further step of moving the infra-bronchial device a predetermined distance into the deployment lumen.
[0021] An embodiment of the invention provides an infra-bronchial device supply tool for supplying an infra-bronchial device in a delivery configuration to a deployment lumen. The tool includes storage means for carrying the infra-bronchial device in a storage configuration, delivery means for loading the infra-bronchial device in a delivery configuration into the deployment lumen, configuration changing means coupled between the storage means and the delivery means for changing the infra-bronchial device from the storage configuration to the delivery configuration as the infra-bronchial device is moved from the storage means to the delivery means, and moving means for moving the intra-bronchial device from the storage means to the delivery means.
[0022] A still further embodiment of the invention provides a lit for delivering an infra-bronchial device into an air passageway. The lcit includes a delivery catheter having a deployment lumen with a distal end arranged to receive the infra-bronchial device in a delivery configuration, and arranged to be passed down a trachea and advanced to a location in an air passageway for deployment of the infra-bronchial device, and to deploy the intra-bronchial device by retracting the deployment catheter. The lit further includes a plurality of bronchial device supply tools, each arranged to carry one infra-bronchial device in a storage configuration, and one infra-bronchial device in a storage configuration carried to each supply tool, each supply tool carrying a different infra-bronchial device.
Brief Description of the Drawings [0023] The features of the present invention which are believed to be novel are set forth with particularity in the appended claims. The invention, together with further objects and advantages thereof, may best be understood by malting reference to the following description talcen in conjunction with the accompanying drawings, in the several figures of which lilce referenced numerals identify like elements, and wherein:
[0024] FIG. 1 is a sectional view of a respiratory system;

[0025] FIG. 2 illustrates an assembly for delivering an infra-bronchial device into an air passageway including a delivery catheter, according to an embodiment of the invention;
[0026] FIG. 3 illustrates a cross-sectional view of the delivery catheter of FIG. 2, according to an embodiment of the invention;
[0027] FIG. 4 illustrates a longitudinal-sectional view of the distal portion of the delivery catheter in a configuration to receive an infra-bronchial device, according to an embodiment of the invention;
[0028] FIG. 5 illustrates a longitudinal-section view of the infra-bronchial device supply tool removably associated with the distal tip of the deployment catheter, according to an embodiment of the invention;
[0029] FIG. 6 is a longitudinal-sectional view of the supply tool of FIG. 5 illustrating the configuration of the infra-bronchial device being changed from a storage configuration to a delivery configuration, according to an embodiment of the invention;
[0030] FIG. 7 is a longitudinal-sectional view of the supply tool of FIG. 5 illustrating the configuration of the infra-bronchial device having been changed from a storage configuration to a delivery configuration, according to an embodiment of the invention;
[0031 ] FIG. 8 is a longitudinal-sectional view of the supply tool of FIG. 5 illustrating the configuration of the infra-bronchial device after having been loaded into the distal end of the deployment catheter, according to an embodiment of the invention;
[0032] FIG. 9 is a longitudinal-sectional view of the supply tool of FIG. 5 illustrating the distal end of the deployment catheter having been disassociated from the supply tool, according to an embodiment of the invention;
[0033] FIG. 10 illustrates a bronchoscope transorally placed into the trachea of a patient, and the delivery catheter carried in a worl~ing lumen of the bronchoscope, in accordance with an embodiment of the invention;
[0034] FIG. 11 illustrates the distal end of the bronchoscope and a partial cross-section view of the distal end of the deployment catheter advanced to a location in an air passageway for deployment of the infra-bronchial device, in accordance with an embodiment of the invention;

[0035] FIG. 12 illustrates a starting configuration where the device is carried in a delivery configuration in the distal end and proximate to the stabilization seat, in accordance with all embodiment of the invention;
[0036] FIG. 13 illustrates an intermediate step where the stabilization seat stabilizes the device at the location for deployment while the distal end is being moved proximally, in accordance with an embodiment of the invention; and [0037] FIG. 14 illustrates a final step where the distal end has been moved proximally until the device has been unsheathed, in accordance with an embodiment of the invention.
Detailed Description [003] In the following detailed description of exemplary embodiments of the invention, reference is made to the accompanying drawings, which form a part hereof. The detailed description and the drawings illustrate specific exemplary embodiments by which the invention may be practiced. These embodiments are described in sufficient detail to enable those slcilled in the al-t to practice the invention. It is understood that other embodiments may be utilized, and other changes may be made, without departing from the spirit or scope of the present invention. The following detailed description is therefore not to be tal~en in a limiting sense, and the scope of the present invention is defined by the appended claims.
[003] Throughout the specification and claims, the following terms tale the meanings explicitly associated herein unless the context dictates otherwise.
The meaning of "a", "an", and "the" include plural references. The meaning of "in" includes "in" and "on."
Additionally, a reference to the singular includes a reference to the plural unless otherwise stated or inconsistent with the disclosure herein.
[0040] Additionally, throughout the specification, claims, and drawings, the term "proximal" means nearest the trachea or the mouth, and "distal" means nearest the alveoli.
[0041] FIG. 1 is a sectional view of a respiratory system. The respiratory system resides within the thorax 22 that occupies a space defined by the chest wall 24 and the diaphragm 26. The respiratory system 20 includes trachea 28; left mainstem bronchus 30 and right mainstem bronchus 32 (primary, or first generation); and lobar bronchial branches 34, 36, 38, 40, and 42 (second generation). FIG. 1 also illustrates segmental branches 44, 46, 48, 49, and 50 (third generation). The respiratory system 20 further includes left lung lobes 52 and 54 and right lung lobes 56, 58, and 60. Each bronchial branch and sub-branch communicates with a different portion of a lung lobe, either an entire lung lobe or a portion thereof. As used herein, the term "air passageway" is meant to denote either a bronchi or bronchioli, and typically means a bronchial branch of any generation.
[0042] The air passageways branch out, much life the roots of a tree. The bronchial segments branch into six generations or a tree orders, and the bronchioles branch into approximately another three to eight generations or orders. Typically, each generation has a smaller diameter than does its predecessor. The inside diameter of a generation varies depending on the particular bronchial branch, and further varies between individuals. For example, a typical lobar bronchus 42 (third generation) providing air circulation to the upper right lobe 56 has an internal diameter of approximately 1 cm. Typical segmental bronchi 48 (fourth generation) have internal diameters of approximately 4 to 7 mm. The fifth and sixth generations (no reference numbers) are each proportionately smaller. The bronchial segments include annular ligaments and irregularly located cartilage that provide structure and resilience. Furthermore, the inside diameters of air passageways are not static. They expand when a person inhales and contract when a person exhales.
[0043] Intra-bronchial devices may be delivered and deployed in one or more air passageways in a patient, depending on the therapeutic objective. As described previously, variation in air passageway diameters requires different sizes of intra-bronchial devices be available to correctly fit a device to an air passageway.
[0044] FIGS. 2-5 are related. FIG. 2 illustrates an assembly 100 for delivering an intra-bronchial device in an air passageway including delivery catheter 110, according to an embodiment of the invention. The assembly 100 includes a delivery catheter 110, and a bronchial device supply (or loading) tool 200. FIG. 3 illustrates a cross-sectional view of the delivery catheter 110 of FIG. 2, according to an embodiment of the invention.
FIG. 4 illustrates a longitudinal sectional view of the distal portion of the delivery catheter 110 in a configuration to receive an intra-bronchial device, according to an embodiment of the invention. A description of the intra-bronchial device supply tool 200 is provided in conjunction with FIG. 5.

[0045] The delivery catheter 110 includes a deployment catheter 120, a stabilization member 150, an actuator 180, and optimally a strain-relief catheter 170. The delivery catheter 110 is dimensioned for use in a worlcing channel of a bronchoscope or other instrument providing endoscopic viewing and instrumentation in air passageways, and may be sterilizable. In some embodiments it may be desirable to provide radiopaque marl~ers in portions of the delivery catheter in order to aide in visualization of the catheter and/or the infra-bronchial device during deployment.
[0046] The strain-relief catheter 170 has a lumen 172, and is structured to surround and protect a proximal portion of the deployment catheter 120. The strain-relief catheter 170 is further structured for being griped to maneuver the delivery catheter 110, and to anchor the delivery catheter 110 to a bronchoscope.
[0047] The deployment catheter 120 includes a deployment lumen 122 that is structured-to be partially carried within lumen 172, and steerable into air passageways. The distal end 130 portion of the deployment lumen 122 is arranged to receive the infra-bronchial device in a delivery configuration, and further arranged f~r passage down a trachea and advancement into an air passageway to a location for deployment of the infra-bronchial device. The stabilization member 150 is structured to be carried within deployment lumen 122, and to flex in conjunction with steering of the deployment catheter 120.
[004] The actuator 180 is an extracorporeal member for steering the deployment catheter 110, and for retracting the distal end 130 to deploy an infra-bronchial device carried in the deployment catheter 120. The actuator 180 includes a body 181, a fixed handle 182, a movable handle 184, and a fitting portion 186 for anchoring the actuator 180 to a bronchoscope. The actuator 180 may have any configuration and appropriate ergonomics l~nown to those slcilled in the art, such as a syringe, gun, pencil, or other design. The actuator 180 is illustrated for convenience in FIG. 2 with a "reverse" syringe configuration for a thumb to rest against the fixed handle 182, and for fingers of the same hand to pull (retract) the moveable handle 184 toward the fixed handle 182 in the retraction direction 188. The body 181 is structured to couple the proximal end of the stabilization member 150 and the proximal end of the strain- relief catheter 170 such that one is not longitudinally moveable relative to the other. The fixed handle 182 is coupled to the body 181. The deployment catheter 120 is structurally coupled to the moveable handle 184, which is arranged to move (retract) in the retraction direction 188 to retract the deployment catheter 120 while the stabilization member 150 and the strain- relief catheter do not move longitudinally. As will be described in conjunction with subsequent figures, movement in the retraction direction 188 will deploy the infra-bronchial device from deployment catheter 120.
[0049] The assembly for deploying an infra-bronchial device 110 is typically provided with the bronchial device supply tool 200 removably associated with the distal end 130 of the deployment catheter 120, and an infra-bronchial device in a storage configuration carried in a storage portion (or cavity) of the tool 200. As described in subsequent figures, the supply tool 200 is used to load the infra-bronchial device in a delivery configuration into a distal end 130. The supply tool 200 is then disassociated from the deployment catheter 120, and the distal end 130 of the deployment catheter is ready to be passed through a worl~ing lumen of a bronchoscope, and advanced into a location in an air passageway for deployment of the device.
[000] Turning now to FIG. 4, the delivery catheter 110 includes the deployment catheter 120 having a distal end 130 and a distal tip 132, and the stabilization member 150 having an infra-bronchial device stabilization seat 152 on a distal end. The distal portion of the delivery catheter 110 also includes a portion of the deployment lumen 122 between the distal tip 132 and the stabilization seat 152 defining a distal sheath 134. In some embodiments it may also be desirable to malce the stabilization seat 152 of a radiopaque material so as to allow visualization of the distal end of the stabilization rod during deployment. Alternatively, radiopaque marlcers could be provided on other portions of the stabilization member 150.
[0051] The deployment lumen 122 includes a material having a relatively hard and/or smooth surface to prevent anchors or other features of an infra-bronchial device from engaging the deployment lumen 122 and interfering with deployment. As described below, the material may be medical-catheter-grade nylon 12. The stabilization seat 152 is arranged to stabilize the received infra-bronchial device in the distal end of the deployment catheter lumen.
[0052] FIG. 4 further illustrates a device-receiving configuration. The stabilization seat 152 is located proximal of the distal tip 132 in lumen 122 by a distance preferably of at least equal to a length of a device in a delivery configuration, thus defining a space for receiving the device in a delivery configuration that is wholly within the lumen 122. This space forms the distal sheath 134, which is arranged to receive an intra-bronchial device in a delivery configuration.
[0053] An embodiment of the delivery catheter 110 was constructed using sterilizable materials. The strain-relief catheter 170 includes straight-walled, reinforced medical-grade polyimide tubing having an outside diameter of approximately 0.076 inches, selected to be smaller than the 2 mm working lumen of a common bronchoscope.
The strain-relief catheter further has a length of approximately 12 inches, and its lumen 172 has an inside diameter of approximately 0.055 - 0.060 inches. The deployment catheter 120 is made from a tapered, nylon 12 tubing approximately 45 inches long. It has a proximal end outside diameter of approximately 0.050-0.055 inches with a deployment lumen 122 inside diameter of approximately 0.040 inches, and a distal end 130 outside diameter of approximately 0.076 inches, and a deployment lumen 122 inside diameter of approximately 0.065 inches.
[0054.] The stabilization member 150 is made from a Teflon- coated, stainless steel wire coiled about a center "core" wire approximately 44 inches long (slightly shorter than the deploylnent catheter), has a diameter of 0.038-0.040 inches, and includes a stabilization seat 152 carried on its distal end. The last, approximately four inches of the distal end of the stabilization member 150 is designed to be more flexible than the remaining portion of the wire. The proximal end of the coiled wire is terminated with solid wire for crnnping in place to the actuator 180. The stabilization seat 152 is about 0.100 inches long, has an outside diameter of 0.060 inches, which is slightly less than the diameter of delivery lumen 122, and contains a concave portion in a face arranged to contact a proximal end of the intra-bronchial device.
[0055] An embodiment of actuator 180 was constructed utilizing sterilizable plastic. The moveable handle 184 is coupled to the deployment catheter 120, and a slot 183 is used to limit the movement of the moveable handle 184 and correspondingly the movement of the deployment catheter 120. The strain-relief catheter 170 and the stabilization member 150 are coupled to the body 181, with provision for the deployment catheter 120 to move relative to the strain-relief catheter 170 and the stabilization member 150 in the retraction direction 188.

[0056] FIG. 5 illustrates a longitudinal-section view of the infra-bronchial device supply tool 200 removably associated with the distal tip 130 of the deployment catheter 120, according to an embodiment of the invention. The supply tool 200 is illustrated with an intra-bronchial device 250 that comprises an obstructing member 252 and anchors 254.
This type of infra-bronchial device is described in the anchored device applications mentioned above.
The device 250 is carried in a storage configuration. The supply tool 200 includes a pushing member 202, a body 220, and a retaining clip 242.
[0057] The body 220 includes a cap 222, a housing 224 and an associating portion 240. The cap 222 is arranged for coupling with the housing 224 in any manner known in the art compatible with the materials and intended function of the supply tool 200, which may include threads or adhesive. The cap 222 includes an aperture, and optionally, a support for the pushing member 202. Pushing member 202 includes a plunger 204 and a stop 206. The housing 224 includes a storage portion (or cavity) 226, a configuration- changing portion 228, a delivery portion 230, and an associating portion 240. The associating portion 240 includes a mating face 232, a retaining clip 242, and a gasl~et 244.
[005&] In an embodiment, the supply tool 200 is a non- reusable product arranged to store, transpout, and load a single device. In this embodiment, the supply tool 200 is made from any plastic material known to those in the art compatible with its intended function. The housing 224 is generally cylindrical, and has a generally conical-shaped barrel forming the storage portion 226, the configuration-changing p~ution 228, and the delivery portion 230.
The narrowing or conical shape of the storage poution 226 allows it to store a plurality of sues of an infra-bronchial device 250 by positioning a particular device to be stored at a diameter appropriate for storage of that size. The narrowing or conical shape of the configuration-changing portion 228 compresses or collapses an infra-bronchial device 250 into a delivery configuration as it is moved from the storage portion 226 to the delivery portion 230.
[0059] While FIG. 5 illustrates both the storage portion 226 and configuration-changing portion 228 as including a narrowing passage with a uniformly decreasing diameter, each portion may have unique characteristics. For example, the storage portion 226 may comprise a series of discrete portions becoming narrower proceeding from the cap 222 end of the body 220 toward the associating portion 240, each discrete portion being dimensioned to store a size of the infra-bronchial device 250. Furthermore, the configuration-changing portion 228 may have a continuously changing diameter that changes less rapidly toward the delivery portion 230.
[0060] The delivery portion 230 is intended to establish the delivery configuration for the infra-bronchial device 250, and to match the diameter of the deployment lumen 122 for loading the device 250 into the deployment lumen 122. FIG. 5 illustrates the delivery portion 230 having a longitudinal dimension approximating a length of the infra-bronchial device 250 in the delivery configuration. However, this longitudinal dimension may be reduced such that the delivery portion 230 is the smallest diameter of the configuration-changing portion 228. h1 one embodiment, the diameter of the delivery portion is preferably smaller than the smallest expected internal diameter of a deployment lumen, thereby allowing a single loading tool 200 to be used for loading infra-bronchial devices into deployment lumens of a plurality of sizes. In an alternative embodiment, the distal end 130 comprises a distal end of a working cllarnlel of a bronchoscope. Thus, according to this alternative embodunent, the delivery portion 230 of the loading tool 200 can be configured to load an infra-bronchial device directly into a worlcing lumen of a bronchoscope.
[0061] Associating portion 240 is structured to removably associate the supply tool 200 with the distal end 130 of deployment catheter 120. The mating face 232 is generally perpendicular to a longitudinal axis of the supply tool 200, and arranged to mate with the distal tip 132 such that the longitudinal axis of the deployment lumen 122 and the delivery portion 230 align for loading the infra-bronchial device 250 in a delivery configuration into the deployment lumen 122. The retaining clip 242 and the gasket 244 are arranged to further control the alignment of the delivery portion 230 and the deployment lumen 122, and to removably associate or couple the supply tool 200 to the deployment catheter 120.
[0062] An embodiment of the body 220 may include a breathable, sterile barner 262 caiTied in breathable barrier opening 260. The breathable, sterile barrier 262 may be any breathable barner lcnown in the art for facilitating in-package sterilization, such as TYVEI~~
brand substrate, a registered trademark of du Pont de Nemours and Company. The breathable barrier 262 allows the device 250 to be sterilized after it is stored in the storage part 226.
Sterilization methods may 23 include any method laiown to those skilled in the art, including using an ethylene oxide (Et0) gas, electron beam radiation, or other suitable sterilization method. The loading tool, delivery catheter and infra-bronchial device can be sterilized before or after loading of the infra-bronchial device into the deployment lumen.
[0063] The cap 222 is arranged in cooperation with the housing 224 to form an enclosed space for storing and protecting the infra-bronchial device 250. The cap 222 may also be arranged in cooperation with the housing 224 to form a gripable structure for operation of the pushing member 202. The pushing member 202 may be made from any material l~nown in the art suitable for the intended purpose of the tool 200, including a metal or a plastic. One end of the pushing member 202 is arranged for placement and pushing on the device 250. The other end includes a plunger 204, and a stop 206 arranged to limit the advancement of the pushing member 220.
[0064] In use, a single infra-bronchial device 250 is placed proximate to the storage portion 226, and the cap 222 with the pushing member 202 is coupled to the housing 224. The plunger 204 is moved in direction 20~ to push on and move the device 250 toward the storage portion 226. This moves the infra-bronchial device 250 into an increasingly narrow portion of the storage portion 226 until it assmnes a storage configuration in storage portion 226. While the storage configuration may be different for different types of devices, device 250 typically would be advanced until a portion of its obstructing member 252 and its anchors 254 loosely contact the walls of the storage portion, thus holding the device 250 in a position. If not previously associated, the distal end 130 is associated with the supply tool 200 with the retaining clip 242, forming the assembly 100 described in FIG. 2.
The mating face 232 is brought proximate to, and aligned with, the distal tip 132, and the retaining clip 242 operated to complete the association. If sterilization is to be performed, the device 250 may be sterilized through the breathable, sterile barrier 262 using an ethylene oxide (Et~) gas. If desired, a lubricating substance such as a glycerin solution, silicon, or other medically-acceptable substance can be provided between the infra-bronchial device 250 and the Timer wall of the configuration-changing portion. Such a lubricating substance could be coated onto an exterior surface of the infra-bronchial device 250 prior to placing the infra-bronchial device into the storage cavity 220.
[0065] FIG. 6 is a longitudinal-sectional view of the supply tool 200 of FIG.

illustrating the configuration of infra-bronchial device 250 being changed from a storage configuration to a delivery configuration, according to an embodiment of the invention.
Some reference numbers are omitted for clarity. When the device 250 is needed for delivery into an air passageway, the pushing member 202 is advanced as illustrated in FIG. 6 in the direction indicated by arrow 208 toward the distal end 130. This advancement moves the device 250 into increasingly narrower longitudinal segments of the configuration-changing portion 228 of the housing 224, correspondingly reducing radial dimensions of the device 250 toward its delivery configuration.
[0066] FIG. 7 is a longitudinal-sectional view of the supply tool 200 of FIG.

illustrating the configuration of intra-bronchial device 250 having been changed from a storage configuration to a delivery configuration, according to an embodiment of the invention. The pushing member 202 has been further advanced in the direction indicated by arrow 208 toward the distal end 130. This further advancement has moved the device 250 through increasingly narrower longitudinal segments of the configuration-changing portion 228 and into the delivery portion 230 of the housing 224, correspondingly reducing radial dimensions of the device 250 to its delivery configuration. As described above, the longitudinal dimension of the delivery portion 230 may be reduced such that the delivery portion 230 is at the smallest diameter of the configuration-changing portion 228.
[0067] FIG. 8 is a longitudinal-sectional view of the supply tool 200 of FIG.

illustrating the configuration of intra-bronchial device 250 having been loaded into the distal end 130 of the deployment catheter 120, according to an embodiment of the invention. The pushing member 202 has been further advanced in the direction indicated by arrow 208, moving the device 250, in the delivery configuration, into the delivery lumen 122 proximate to the stabilization seat 152 in preparation for deployment. Advancement of the pushing member 202 may be limited by the stop 206 moving proximate to the cap 222. The stop 206 may be located on pushing member 202 to limit the advancement of the device 250 into the deliver y lumen 122 to a predetermined distance.
[0068] FIG. 9 is a longitudinal-sectional view of the supply tool 200 of FIG.

illustrating the distal end 130 of the deployment catheter 120 having been disassociated from the supply tool 200, according to an embodiment of the invention. The retainer clips 242 are released, and the distal end 130 and the association portion 240 of the tool 200 can be moved apart to disassociate. With disassociation, the distal end 130 is ready for advancement into an air passageway and deployment of the device 250.
[0069] If a particular type of infra-bronchial device can be stored in a delivery configuration, the supply tool 200 can be used to preload the device 250 into the distal end 130. This allows the assembly 100 of FIG. 2 to be provided without the supply tool 200.
[0070] A final series of figures illustrate the delivery catheter 110 delivering the infra-bronchial device 250 into an air passageway. FIG. 10 illustrates a bronchoscope 300 transorally placed in the trachea 28 of a patient, and the delivery catheter 110 carried in a worlcing lumen of the bronchoscope, in accordance with an embodiment of the invention.
FIG. 11 illustrates the distal end 310 of the bronchoscope 300 and a partial longitudinal-section view of the distal end 130 of the deployment catheter 120 advanced to a location in an air passageway for deployment of the infra-bronchial device 250, in accordance with an embodiment of the invention.
[0071] An initial step in delivering an infra-bronchial device 250 requires that the distal end 130 of the deployment catheter 120, also referred to as distal sheath 134, receive the device selected for delivery. An aspect of the invention provides alternative ways for loading a selected infra-bronchial device into the distal end 130. An assembly 100 may be selected having an appropriately sized infra-bronchial device 250 carried in loading tool 200.
The loading tool 200 is used to move the infra-bronchial device 250 into a delivery configuration and load it into the distal tip 130, and then disassociated, as described in conjunction with FIGS. 6-9. In another embodiment, a plurality of loading tools 200 is available, each containing a different size of infra-bronchial device 250. A
loading tool 200 may be selected having an appropriately sized device 250 carried therein. The selected loading tool 200 is associated with the distal tip 130 of the deployment catheter 120 and used to load the device 250 as described above. In a further embodiment where the deployment catheter 120 is provided with the infra-bronchial device 250 preloaded in the distal tip 130, a deployment catheter 120 carrying an appropriately sized device 250 is selected.
[0072] Bronchoscope 300 is transorally placed in the trachea 28 using lcnown techniques, and its distal end 310 is advanced and steered into a selected air passageway near a location for deployment of the infra-bronchial device 250. For the purposes describing an embodiment of the invention, segmental branch 48 is used to illustrate a location in an air passageway for deployment. The distal end 310 may be steered using the visualization element 320, or other visualization technique known to those in the art. Once the distal end 310 is within worlcing distance of the location, the distal end 130 of the deployment catheter 120 carrying a selected infra-bronchial device 250 is advanced from the distal end of a worl~ing lumen of the bronchoscope 300 to the location as illustrated in FIG.
11.
[0073] FIGS. 12 -14 illustrate partial longitudinal-section views of the distal end 130 of the deployment catheter 120 advanced to the location in an air passageway for deployment of the infra-bronchial device 250 and deploying the device 250, in accordance with an embodiment of the invention. FIG. 12 illustrates a starting configuration where the device 250 is carried in a delivery configuration in the distal end 130 and proximate to the stabilization seat 152. Once the distal end 130 is positioned at the location, the moveable handle 184 of the actuator 180 is moved in the retraction direction 188 as illustrated in FIG.
10. Since moveable handle 184 is coupled to the deployment catheter 120 and the stabilization member 150 is coupled to the fixed body 181, movement of the moveable handle 184. in the retraction direction 188 moves the distal end 130 proximal of the device 250 while the stabilization seat 152 stabilizes the device 250 at the location.
[0074] FIG. 13 illustrates an intermediate step when a the stabilization seat stabilizes the device 250 at the location for deployment while the distal end 130 is being moved proximally. In the illustrated intermediate step, the anchors 254. have deployed while the obstructing member 254. remains within the delivery lumen 122. Continuing movement of the handle 184 in the retraction direction 188 further moves the distal end 130 proximal of the device 250 and completes deployment of the device 250 at the location.
FIG. 14 illustrates a final step where the distal end 130 has been moved proximally Lentil the device 250 has been unsheathed and deployed at the location for deployment.
[0075] In a further step, the deployment catheter 120 is removed from the bronchoscope 300. In another embodiment, the deployment catheter 120 can be removed and reloaded with another selected device 250 from another loading tool 200, and the steps repeated to deploy the another device 250 at another location. 111 a further embodiment, a deployment catheter 120 with another preloaded device 250 can be selected and the steps repeated to deploy the another device 250 at another location.

[0076] The invention disclosed herein is not limited to use with the particular method illustrated herein. For example, the delivery catheter 110 may be used alone to perform the delivery, may be extended from the bronchoscope 300, or used in conjunction with the bronchoscope 300. For purposes of this description, the delivery has been described with reference to only the catheter 110 being extended from the bronchoscope 300.
[0077] Although the present invention has been described in considerable detail with reference to certain preferred embodiments, other embodiments are possible. Therefore, the spirit or scope of the appended claims should not be limited to the description of the embodiments contained herein. It is intended that the invention resides in the claims hereinafter appended.

Claims (51)

1. A loading tool for supplying and compressing an intra-bronchial device from a relaxed, radially expanded storage configuration into a radially compressed delivery configuration, the tool comprising: a storage cavity having parallel side walls configured to carry the intra-bronchial device in a storage configuration; a delivery portion configured to load the intra-bronchial device in a delivery configuration into a lumen of a deployment catheter; a longitudinal configuration-changing portion coupled between the storage cavity and the delivery portion, the configuration-changing portion being configured to compress the intra-bronchial device from the storage configuration to the delivery configuration as the intra-bronchial device is moved from the storage cavity to the delivery portion; and a pushing member configured to push the intra-bronchial device from the storage cavity to the delivery portion.
2. The loading tool of Claim 1, wherein the storage cavity is substantially enclosed.
3. The loading tool of Claim 1 or 2, further comprising a cap enclosing the storage cavity.
4. The loading tool of Claim 3, wherein the pushing member extends through a central hole in the cap.
5. The loading tool of any of the preceding claims, wherein the storage cavity is further configured to carry a plurality of sizes of intra-bronchial devices.
6. The loading tool of any of the preceding claims, wherein the intra-bronchial device is a one-way valve configured to be implanted in an air passageway to prevent inhaled air from passing the valve while allowing expired air and/or fluid to pass the valve.
7. The loading tool of Claim 6, wherein the one-way valve is an umbrella-shaped valve configured to allow expired air and/or fluid to flow between a flexible membrane and the air passageway wall.
8. The loading tool of any of the preceding claims, wherein the pusher contacts and pushes against an axially central portion of the intra-bronchial device.
9. The loading tool of any of the preceding claims, wherein the pushing member is further configured to move the intra-bronchial device a predetermined distance into the deployment lumen.
10. The loading tool of any of the preceding claims, wherein the loading tool and the intra-bronchial device carried therein are sterilized and/or cleaned.
11. The loading tool of any of the preceding claims, wherein the storage cavity comprises a section that is permeable to ethylene oxide to allow the intra-bronchial device to be sterilized by the etheylene oxide.
12. The loading tool of any of the preceding claims further comprising a lubricating substance on an inner surface of the configuration-changing portion and/or on an external surface of an intra-bronchial device stored in the storage cavity.
13. The loading tool of any of the preceding claims, wherein the tool is made of a material that is sterilizable by radiation.
14. The loading tool of any of the preceding claims, further comprising an intra-bronchial device in a storage configuration carried in the storage cavity.
15. The loading tool of any of the preceding claims, wherein the configuration-changing portion includes a narrowing passage extending between the storage cavity and the delivery portion.
16. The loading tool of any of the preceding claims, wherein the configuration-changing portion includes a passage having a continuously decreasing diameter.
17. The loading tool of any of the preceding claims, wherein the intra-bronchial device does not include a passage through its center.
18. The loading tool of any of the preceding claims, further comprising a coupler configured to associate the delivery portion of the loading tool with the deployment lumen for loading an intra-bronchial device into the deployment lumen.
19. A loading tool for compressing an implantable intra-bronchial device from an expanded shape to a compressed shape, the tool comprising: a housing having a longitudinal axis and at least one continuous side wall forming a storage cavity, a compressing section and a loading section; wherein the side wall is parallel to the longitudinal axis in the storage section, tapers towards the longitudinal axis in the compressing section from larger at the storage cavity to smaller at the loading section, and is parallel to the axis in the loading section; and a push rod extending through an axial center of at least a portion of the storage cavity to push an intra-bronchial device from the storage cavity, through the compressing section and into the loading section.
20. The loading tool of Claim 19, wherein a first end of the housing is defined at an end opposite the loading section, the loading tool comprising a cap attached to the first end and enclosing the storage cavity.
21. The loading tool of Claim 20, further comprising a push rod extending through the cap.
22. The loading tool of Claim 21, wherein the push rod comprises a protrusion for stopping an axial advancement of the push rod into the loading section.
23. The loading tool of Claim 22, further comprising a lubricating substance between an intra-bronchial device and the side wall of the compressing section.
24. The loading tool of Claim 21 or 22, wherein the push rod contacts an axial center of the intra-bronchial valve.
25. The loading tool of any of Claims 19-24, wherein the storage cavity has a circular axial cross-section with a first diameter, and the loading section has a circular axial cross-section with a second diameter.
26. The loading tool of Claim 25, wherein the first diameter is larger than a maximum expanded diameter of an intra-bronchial device to be stored therein.
27. The loading tool of Claim 25 or 26, wherein the second diameter of the loading section is no larger than an inner diameter of a deployment lumen.
28. The loading tool of any of Claims 19-27, wherein the side walls of the compressing section taper linearly.
29. The loading tool of any of Claims 19-28, further comprising a retaining clip and a gasket for receiving and retaining a distal end of a delivery catheter having a deployment lumen for receiving an intra-bronchial device from the loading tool.
30. The loading tool of any of Claims 19-29, further comprising an umbrella-shaped intra-bronchial one-way valve stored therein.
31. The loading tool of any of Claims 19-30, wherein a portion of the side wall comprises a section of material that is permeable to selected sterilizing gases.
32. An assembly for delivering an intra-bronchial device into an air passageway, the assembly comprising: a delivery catheter having a deployment lumen with a distal end configured to receive the intra-bronchial device in a delivery configuration, and configured to be passed down a trachea and advanced to a location in an air passageway for deployment of the intra-bronchial device to deploy the intra-bronchial device by retracting the distal end of the deployment lumen relative to the intra-bronchial device, characterized by a loading tool as in any of the preceding claims associated with the distal end of the deployment lumen; and an intra-bronchial device carried in the loading tool in an expanded storage configuration.
33. The assembly of Claim 32, wherein the deployment lumen is a portion of a deployment catheter located within the delivery catheter.
34. The assembly of Claim 32, wherein the deployment lumen is a working channel of a bronchoscope.
35. The assembly of Claim 32-34, further comprising a stabilization member configured to be carried in the deployment lumen and to stabilize the intra-bronchial device in a stationary location relative to the air passageway during retraction of the distal end of the deployment catheter.
36. The assembly of any of Claims 32-35, wherein the deployment catheter and the stabilization member are configured to move longitudinally relative to each other such that retracting the deployment catheter relative to the stabilization member releases the intra-bronchial device from the deployment lumen.
37. The assembly of Claim 32-36, further comprising an actuator configured to allow an operator to maintain the stabilization member in a position while retracting the deployment catheter.
38. The assembly of Claim 32 or 37, wherein the delivery catheter is configured to be sterilized.
39. The assembly of any of Claims 32-38, further comprising an outer catheter such as a strain-relief catheter surrounding at least a portion of the delivery catheter.
40. The assembly of any of Claims 32-39, wherein the stabilization member and the strain-relief catheter are coupled such that one is not longitudinally moveable relative to the other.
41. The assembly of any of Claims 32-40, further including an actuator having a first portion coupling the stabilization member and the strain-relief catheter, the actuator configured to allowing an operator to maintain the stabilization member in a desired location, and a second portion allowing the operator to retract the deployment catheter.
42. The assembly of any of Claims 32-41, wherein the deployment lumen comprises .a distal sheath configured to receive the intra-bronchial device in a delivery configuration and to deploy the intra-bronchial device by unsheathing.
43. A method of cleaning and/or sterilizing an intra-bronchial device comprising:
placing an intra-bronchial device in a relaxed, expanded state into a storage cavity of a loading tool as defined in any of the preceding claims, enclosing the storage cavity, and sterilizing the loading tool and the intra-bronchial device simultaneously.
44. The cleaning and/or sterilizing method of Claim 43, further comprising attaching a deployment catheter to a loading portion of the loading tool prior to cleaning and/or sterilizing.
45. The cleaning and/or sterilizing method of Claim 43 or 45, wherein enclosing the storage cavity comprises attaching a removable cap having a pushing member extending therethrough.
46. A method of radially compressing an intra-bronchial device comprising:
after the sterilizing step in one of Claims 43-45, pushing the intra-bronchial device from the storage cavity, through a tapering passage of the loading tool, and into a lumen of the deployment catheter, the lumen having a diameter that is substantially smaller than a diameter of the storage cavity.
47. The method of Claim 46, wherein said pushing is performed with a pushing rod extending through a cap enclosing the storage cavity.
48. A method of delivering an intra-bronchial device into an air passageway, the method comprising: moving the intra-bronchial device from a storage configuration to a delivery configuration by compressing the device according to the method of Claim 33 or 34;
loading the intra-bronchial device in a delivery configuration into a distal end of the deployment catheter; advancing the distal end of the deployment catheter down a trachea to a location in an air passageway; stabilizing the intra-bronchial device at the location; and retracting the distal end to deploy the intra-bronchial device.
49. The method of Claim 48, further comprising removing the loading tool from the distal end of the deployment catheter.
50. The method of Claim 48 or 49, further comprising moving the intra-bronchial device a predetermined distance into the deployment lumen.
51. A kit for delivering an intra-bronchial device into an air passageway of a lung, the kit comprising: a delivery device as defined in any of the preceding claims, a loading tool as defined in any of the preceding claims, at least one intra-bronchial device, and instructions for use according to a method of any of Claims 46-50.
CA002518862A 2003-03-12 2004-03-12 Apparatus, method and assembly for delivery of intra-bronchial devices Abandoned CA2518862A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/387,963 US20040210248A1 (en) 2003-03-12 2003-03-12 Apparatus, method and assembly for delivery of intra-bronchial devices
US10/387,963 2003-03-12
PCT/US2004/007721 WO2004080347A2 (en) 2003-03-12 2004-03-12 Apparatus, method and assembly for delivery of intra-bronchial devices

Publications (1)

Publication Number Publication Date
CA2518862A1 true CA2518862A1 (en) 2004-09-23

Family

ID=32987342

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002518862A Abandoned CA2518862A1 (en) 2003-03-12 2004-03-12 Apparatus, method and assembly for delivery of intra-bronchial devices

Country Status (6)

Country Link
US (1) US20040210248A1 (en)
EP (1) EP1610712A2 (en)
JP (1) JP2006519665A (en)
AU (1) AU2004220453A1 (en)
CA (1) CA2518862A1 (en)
WO (1) WO2004080347A2 (en)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6994706B2 (en) 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
US20030050648A1 (en) 2001-09-11 2003-03-13 Spiration, Inc. Removable lung reduction devices, systems, and methods
US6592594B2 (en) 2001-10-25 2003-07-15 Spiration, Inc. Bronchial obstruction device deployment system and method
US20030154988A1 (en) * 2002-02-21 2003-08-21 Spiration, Inc. Intra-bronchial device that provides a medicant intra-bronchially to the patient
US6929637B2 (en) 2002-02-21 2005-08-16 Spiration, Inc. Device and method for intra-bronchial provision of a therapeutic agent
US20030216769A1 (en) 2002-05-17 2003-11-20 Dillard David H. Removable anchored lung volume reduction devices and methods
US20030181922A1 (en) 2002-03-20 2003-09-25 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US7100616B2 (en) 2003-04-08 2006-09-05 Spiration, Inc. Bronchoscopic lung volume reduction method
US7811274B2 (en) 2003-05-07 2010-10-12 Portaero, Inc. Method for treating chronic obstructive pulmonary disease
US7426929B2 (en) 2003-05-20 2008-09-23 Portaero, Inc. Intra/extra-thoracic collateral ventilation bypass system and method
US7252086B2 (en) 2003-06-03 2007-08-07 Cordis Corporation Lung reduction system
US7377278B2 (en) 2003-06-05 2008-05-27 Portaero, Inc. Intra-thoracic collateral ventilation bypass system and method
US7682332B2 (en) 2003-07-15 2010-03-23 Portaero, Inc. Methods to accelerate wound healing in thoracic anastomosis applications
US7533671B2 (en) 2003-08-08 2009-05-19 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US7670282B2 (en) 2004-06-14 2010-03-02 Pneumrx, Inc. Lung access device
EP1781182B1 (en) 2004-07-08 2019-11-13 PneumRx, Inc. Pleural effusion treatment device
US7766891B2 (en) 2004-07-08 2010-08-03 Pneumrx, Inc. Lung device with sealing features
US20060162731A1 (en) 2004-11-16 2006-07-27 Pulmonx Pulmonary occlusal stent delivery catheter, loading system and methods of use
US8220460B2 (en) 2004-11-19 2012-07-17 Portaero, Inc. Evacuation device and method for creating a localized pleurodesis
US9211181B2 (en) 2004-11-19 2015-12-15 Pulmonx Corporation Implant loading device and system
US7771472B2 (en) 2004-11-19 2010-08-10 Pulmonx Corporation Bronchial flow control devices and methods of use
JP4874259B2 (en) 2004-11-23 2012-02-15 ヌームアールエックス・インコーポレーテッド Steerable device for accessing the target site
US7824366B2 (en) 2004-12-10 2010-11-02 Portaero, Inc. Collateral ventilation device with chest tube/evacuation features and method
US8104474B2 (en) 2005-08-23 2012-01-31 Portaero, Inc. Collateral ventilation bypass system with retention features
US9265605B2 (en) 2005-10-14 2016-02-23 Boston Scientific Scimed, Inc. Bronchoscopic lung volume reduction valve
US8545530B2 (en) 2005-10-19 2013-10-01 Pulsar Vascular, Inc. Implantable aneurysm closure systems and methods
CA2625826C (en) 2005-10-19 2014-08-05 Pulsar Vascular, Inc. Methods and systems for endovascularly clipping and repairing lumen and tissue defects
US7406963B2 (en) 2006-01-17 2008-08-05 Portaero, Inc. Variable resistance pulmonary ventilation bypass valve and method
US8888800B2 (en) 2006-03-13 2014-11-18 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US8157837B2 (en) 2006-03-13 2012-04-17 Pneumrx, Inc. Minimally invasive lung volume reduction device and method
US9402633B2 (en) 2006-03-13 2016-08-02 Pneumrx, Inc. Torque alleviating intra-airway lung volume reduction compressive implant structures
US7691151B2 (en) 2006-03-31 2010-04-06 Spiration, Inc. Articulable Anchor
US8100959B2 (en) 2007-03-09 2012-01-24 Pulmonx Corporation Loading device for a pulmonary implant
US8163034B2 (en) 2007-05-11 2012-04-24 Portaero, Inc. Methods and devices to create a chemically and/or mechanically localized pleurodesis
US7931641B2 (en) 2007-05-11 2011-04-26 Portaero, Inc. Visceral pleura ring connector
US8062315B2 (en) 2007-05-17 2011-11-22 Portaero, Inc. Variable parietal/visceral pleural coupling
US8043301B2 (en) * 2007-10-12 2011-10-25 Spiration, Inc. Valve loader method, system, and apparatus
EP2194933B1 (en) * 2007-10-12 2016-05-04 Spiration, Inc. Valve loader method, system, and apparatus
US8475389B2 (en) 2008-02-19 2013-07-02 Portaero, Inc. Methods and devices for assessment of pneumostoma function
WO2009105432A2 (en) 2008-02-19 2009-08-27 Portaero, Inc. Devices and methods for delivery of a therapeutic agent through a pneumostoma
US8336540B2 (en) 2008-02-19 2012-12-25 Portaero, Inc. Pneumostoma management device and method for treatment of chronic obstructive pulmonary disease
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US8992517B2 (en) 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US10448989B2 (en) 2009-04-09 2019-10-22 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US10117707B2 (en) 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
AU2009243079A1 (en) 2008-04-29 2009-11-05 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US8388650B2 (en) 2008-09-05 2013-03-05 Pulsar Vascular, Inc. Systems and methods for supporting or occluding a physiological opening or cavity
US9173669B2 (en) 2008-09-12 2015-11-03 Pneumrx, Inc. Enhanced efficacy lung volume reduction devices, methods, and systems
US8347881B2 (en) 2009-01-08 2013-01-08 Portaero, Inc. Pneumostoma management device with integrated patency sensor and method
US8518053B2 (en) 2009-02-11 2013-08-27 Portaero, Inc. Surgical instruments for creating a pneumostoma and treating chronic obstructive pulmonary disease
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
CN104622599B (en) 2009-05-18 2017-04-12 纽姆克斯股份有限公司 Cross-sectional modification during deployment of an elongate lung volume reduction device
US8903488B2 (en) 2009-05-28 2014-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
KR101788338B1 (en) 2009-09-04 2017-10-19 펄사 배스큘라, 아이엔씨. Systems and methods for enclosing an anatomical opening
US8425455B2 (en) 2010-03-30 2013-04-23 Angiodynamics, Inc. Bronchial catheter and method of use
US9700368B2 (en) 2010-10-13 2017-07-11 Angiodynamics, Inc. System and method for electrically ablating tissue of a patient
US8795241B2 (en) 2011-05-13 2014-08-05 Spiration, Inc. Deployment catheter
WO2012167156A1 (en) 2011-06-03 2012-12-06 Pulsar Vascular, Inc. Aneurysm devices with additional anchoring mechanisms and associated systems and methods
KR102019025B1 (en) 2011-06-03 2019-09-06 펄사 배스큘라, 아이엔씨. Systems and methods for enclosing an anatomical opening, including shock absorbing aneurysm devices
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
ES2809210T3 (en) 2011-10-05 2021-03-03 Pulsar Vascular Inc Systems and devices for wrapping an anatomical opening
JP6411331B2 (en) 2012-05-10 2018-10-24 パルサー バスキュラー インコーポレイテッド Aneurysm device with coil
US20130317339A1 (en) * 2012-05-23 2013-11-28 Biosense Webster (Israel), Ltd. Endobronchial catheter
CH706684A1 (en) * 2012-06-28 2013-12-31 Qvanteq Ag Packaging and transfer system for implant application.
GB2526034B (en) 2013-03-14 2020-03-04 Spiration Inc Valve loader method, system and apparatus
US10471254B2 (en) 2014-05-12 2019-11-12 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
KR20170042288A (en) * 2014-08-15 2017-04-18 늄알엑스, 인코퍼레이티드 Coordinated delivery of copd treatment
US10390838B1 (en) 2014-08-20 2019-08-27 Pneumrx, Inc. Tuned strength chronic obstructive pulmonary disease treatment
WO2016100325A1 (en) 2014-12-15 2016-06-23 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
WO2016153635A1 (en) 2015-03-24 2016-09-29 Spiration, Inc.D/B/A Olympus Respiratory America Airway stent
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US11950835B2 (en) 2019-06-28 2024-04-09 Virginia Tech Intellectual Properties, Inc. Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2981254A (en) * 1957-11-12 1961-04-25 Edwin G Vanderbilt Apparatus for the gas deflation of an animal's stomach
US3540431A (en) * 1968-04-04 1970-11-17 Kazi Mobin Uddin Collapsible filter for fluid flowing in closed passageway
US3760808A (en) * 1969-12-01 1973-09-25 K Bleuer Tampon applicator assembly
US3657744A (en) * 1970-05-08 1972-04-25 Univ Minnesota Method for fixing prosthetic implants in a living body
US3788327A (en) * 1971-03-30 1974-01-29 H Donowitz Surgical implant device
US3874388A (en) * 1973-02-12 1975-04-01 Ochsner Med Found Alton Shunt defect closure system
US4014318A (en) * 1973-08-20 1977-03-29 Dockum James M Circulatory assist device and system
US4086665A (en) * 1976-12-16 1978-05-02 Thermo Electron Corporation Artificial blood conduit
US4250873A (en) * 1977-04-26 1981-02-17 Richard Wolf Gmbh Endoscopes
US4212463A (en) * 1978-02-17 1980-07-15 Pratt Enoch B Humane bleeder arrow
DE3019996A1 (en) * 1980-05-24 1981-12-03 Institute für Textil- und Faserforschung Stuttgart, 7410 Reutlingen HOHLORGAN
US4808183A (en) * 1980-06-03 1989-02-28 University Of Iowa Research Foundation Voice button prosthesis and method for installing same
US4302854A (en) * 1980-06-04 1981-12-01 Runge Thomas M Electrically activated ferromagnetic/diamagnetic vascular shunt for left ventricular assist
US4727873A (en) * 1984-04-17 1988-03-01 Mobin Uddin Kazi Embolus trap
EP0203124B1 (en) * 1984-11-15 1991-06-05 NAZARI, Stefano Device for selective bronchial intubation and separate lung ventilation
ES8705239A1 (en) * 1984-12-05 1987-05-01 Medinvent Sa A device for implantation and a method of implantation in a vessel using such device.
US4759758A (en) * 1984-12-07 1988-07-26 Shlomo Gabbay Prosthetic heart valve
US4681110A (en) * 1985-12-02 1987-07-21 Wiktor Dominik M Catheter arrangement having a blood vessel liner, and method of using it
US4710192A (en) * 1985-12-30 1987-12-01 Liotta Domingo S Diaphragm and method for occlusion of the descending thoracic aorta
US4832680A (en) * 1986-07-03 1989-05-23 C.R. Bard, Inc. Apparatus for hypodermically implanting a genitourinary prosthesis
US4795449A (en) * 1986-08-04 1989-01-03 Hollister Incorporated Female urinary incontinence device
US4852568A (en) * 1987-02-17 1989-08-01 Kensey Nash Corporation Method and apparatus for sealing an opening in tissue of a living being
DE3821631A1 (en) * 1987-07-28 1989-02-09 Bader Paul CLOSURE FOR A MALE UTILITY
US4830003A (en) * 1988-06-17 1989-05-16 Wolff Rodney G Compressive stent and delivery system
US4846836A (en) * 1988-10-03 1989-07-11 Reich Jonathan D Artificial lower gastrointestinal valve
US4877025A (en) * 1988-10-06 1989-10-31 Hanson Donald W Tracheostomy tube valve apparatus
DE3834545A1 (en) * 1988-10-11 1990-04-12 Rau Guenter FLEXIBLE LOCKING ORGAN, PARTICULARLY HEART VALVE, AND METHOD FOR PRODUCING THE SAME
US4968294A (en) * 1989-02-09 1990-11-06 Salama Fouad A Urinary control valve and method of using same
US5314473A (en) * 1989-07-20 1994-05-24 Godin Norman J Prosthesis for preventing gastric reflux into the esophagus
US5061274A (en) * 1989-12-04 1991-10-29 Kensey Nash Corporation Plug device for sealing openings and method of use
US5158548A (en) * 1990-04-25 1992-10-27 Advanced Cardiovascular Systems, Inc. Method and system for stent delivery
US5116360A (en) * 1990-12-27 1992-05-26 Corvita Corporation Mesh composite graft
SE9100675D0 (en) * 1991-03-06 1991-03-06 Sandvik Ab CERAMIC WHISKER-REINFORCED CUTTING TOOL WITH PRE-FORMED CHIPBREAKERS FOR MACHINING
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US5151105A (en) * 1991-10-07 1992-09-29 Kwan Gett Clifford Collapsible vessel sleeve implant
US5123919A (en) * 1991-11-21 1992-06-23 Carbomedics, Inc. Combined prosthetic aortic heart valve and vascular graft
US5283063A (en) * 1992-01-31 1994-02-01 Eagle Vision Punctum plug method and apparatus
US5509900A (en) * 1992-03-02 1996-04-23 Kirkman; Thomas R. Apparatus and method for retaining a catheter in a blood vessel in a fixed position
US5304199A (en) * 1993-01-04 1994-04-19 Gene E. Myers Enterprises, Inc. Apparatus for arterial total occlusion plaque separation
US5797960A (en) * 1993-02-22 1998-08-25 Stevens; John H. Method and apparatus for thoracoscopic intracardiac procedures
US5306234A (en) * 1993-03-23 1994-04-26 Johnson W Dudley Method for closing an atrial appendage
WO1994023786A1 (en) * 1993-04-13 1994-10-27 Boston Scientific Corporation Prosthesis delivery system
US5453090A (en) * 1994-03-01 1995-09-26 Cordis Corporation Method of stent delivery through an elongate softenable sheath
US5803078A (en) * 1994-05-06 1998-09-08 Brauner; Mark E. Methods and apparatus for intrapulmonary therapy and drug administration
US5549626A (en) * 1994-12-23 1996-08-27 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Vena caval filter
US5755770A (en) * 1995-01-31 1998-05-26 Boston Scientific Corporatiion Endovascular aortic graft
US5693089A (en) * 1995-04-12 1997-12-02 Inoue; Kanji Method of collapsing an implantable appliance
US5681347A (en) * 1995-05-23 1997-10-28 Boston Scientific Corporation Vena cava filter delivery system
WO1996037167A1 (en) * 1995-05-25 1996-11-28 Raychem Corporation Stent assembly
US5660175A (en) * 1995-08-21 1997-08-26 Dayal; Bimal Endotracheal device
US5855601A (en) * 1996-06-21 1999-01-05 The Trustees Of Columbia University In The City Of New York Artificial heart valve and method and device for implanting the same
US5725519A (en) * 1996-09-30 1998-03-10 Medtronic Instent Israel Ltd. Stent loading device for a balloon catheter
NL1004827C2 (en) * 1996-12-18 1998-06-19 Surgical Innovations Vof Device for regulating blood circulation.
US5851232A (en) * 1997-03-15 1998-12-22 Lois; William A. Venous stent
US6059812A (en) * 1997-03-21 2000-05-09 Schneider (Usa) Inc. Self-expanding medical device for centering radioactive treatment sources in body vessels
US6488673B1 (en) * 1997-04-07 2002-12-03 Broncus Technologies, Inc. Method of increasing gas exchange of a lung
US5954636A (en) * 1997-07-15 1999-09-21 Schwartz; Roy E. Pediatric endotracheal tube with bronchial blocker and method for selectively blocking respiratory airflow to a pediatric patient's lung
US5954766A (en) * 1997-09-16 1999-09-21 Zadno-Azizi; Gholam-Reza Body fluid flow control device
US6254642B1 (en) * 1997-12-09 2001-07-03 Thomas V. Taylor Perorally insertable gastroesophageal anti-reflux valve prosthesis and tool for implantation thereof
US6132458A (en) * 1998-05-15 2000-10-17 American Medical Systems, Inc. Method and device for loading a stent
US6174323B1 (en) * 1998-06-05 2001-01-16 Broncus Technologies, Inc. Method and assembly for lung volume reduction
US6149664A (en) * 1998-08-27 2000-11-21 Micrus Corporation Shape memory pusher introducer for vasoocclusive devices
ATE248000T1 (en) * 1999-02-01 2003-09-15 Adeva Medical Ges Fuer Entwick TRACHEOSTOMA VALVE
FR2789889B1 (en) * 1999-02-18 2001-04-27 Tokendo Sarl SYSTEM FOR LAYING SEMI-RIGID TUBULAR ENDOPROSTHESES
US6287290B1 (en) * 1999-07-02 2001-09-11 Pulmonx Methods, systems, and kits for lung volume reduction
US6692494B1 (en) * 1999-08-05 2004-02-17 Broncus Technologies, Inc. Methods and devices for creating collateral channels in the lungs
US6610043B1 (en) * 1999-08-23 2003-08-26 Bistech, Inc. Tissue volume reduction
US6293951B1 (en) * 1999-08-24 2001-09-25 Spiration, Inc. Lung reduction device, system, and method
US6203551B1 (en) * 1999-10-04 2001-03-20 Advanced Cardiovascular Systems, Inc. Chamber for applying therapeutic substances to an implant device
US6398775B1 (en) * 1999-10-21 2002-06-04 Pulmonx Apparatus and method for isolated lung access
US6679264B1 (en) * 2000-03-04 2004-01-20 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
GB2369575A (en) * 2000-04-20 2002-06-05 Salviac Ltd An embolic protection system
CA2408923A1 (en) * 2000-05-18 2001-11-22 David Peter Shaw Bronchiopulmonary occlusion devices and lung volume reduction methods
US20020147462A1 (en) * 2000-09-11 2002-10-10 Closure Medical Corporation Bronchial occlusion method and apparatus
JP3408527B2 (en) 2000-10-26 2003-05-19 松下電器産業株式会社 Method for manufacturing semiconductor device
US6585639B1 (en) * 2000-10-27 2003-07-01 Pulmonx Sheath and method for reconfiguring lung viewing scope
US6527761B1 (en) * 2000-10-27 2003-03-04 Pulmonx, Inc. Methods and devices for obstructing and aspirating lung tissue segments
US20020112729A1 (en) * 2001-02-21 2002-08-22 Spiration, Inc. Intra-bronchial obstructing device that controls biological interaction with the patient
US6860847B2 (en) * 2001-07-10 2005-03-01 Spiration, Inc. Constriction device viewable under X ray fluoroscopy
US6743259B2 (en) * 2001-08-03 2004-06-01 Core Medical, Inc. Lung assist apparatus and methods for use
US20030050648A1 (en) * 2001-09-11 2003-03-13 Spiration, Inc. Removable lung reduction devices, systems, and methods
AU2002347900B8 (en) * 2001-10-11 2006-01-12 Emphasys Medical, Inc. Bronchial flow control devices and methods of use
US6592594B2 (en) * 2001-10-25 2003-07-15 Spiration, Inc. Bronchial obstruction device deployment system and method
US20030154988A1 (en) * 2002-02-21 2003-08-21 Spiration, Inc. Intra-bronchial device that provides a medicant intra-bronchially to the patient
US6929637B2 (en) * 2002-02-21 2005-08-16 Spiration, Inc. Device and method for intra-bronchial provision of a therapeutic agent
US7278430B2 (en) * 2002-03-01 2007-10-09 Arvik Enterprises, Llc Blood vessel occlusion device
US20030216769A1 (en) * 2002-05-17 2003-11-20 Dillard David H. Removable anchored lung volume reduction devices and methods
US20030212412A1 (en) * 2002-05-09 2003-11-13 Spiration, Inc. Intra-bronchial obstructing device that permits mucus transport
EP1507491A1 (en) * 2002-05-28 2005-02-23 Emphasys Medical, Inc. Implantable bronchial isolation devices and lung treatment methods

Also Published As

Publication number Publication date
US20040210248A1 (en) 2004-10-21
WO2004080347A3 (en) 2005-06-09
AU2004220453A1 (en) 2004-09-23
WO2004080347A2 (en) 2004-09-23
EP1610712A2 (en) 2006-01-04
JP2006519665A (en) 2006-08-31

Similar Documents

Publication Publication Date Title
CA2518862A1 (en) Apparatus, method and assembly for delivery of intra-bronchial devices
US10370150B2 (en) Two-part package for medical implant
EP1812098B1 (en) Loading system for a pulmonary occlusal stent delivery catheter
EP1496790B1 (en) Device for intra-bronchial provision of a therapeutic agent
CA1315024C (en) Transendoscopic implant capsule
JP2005506873A (en) Loading cartridge for self-expanding stent
US8388682B2 (en) Bronchial flow control devices and methods of use
WO2005074380A2 (en) Directional anchoring mechanism, method and applications thereof
AU2001260840A1 (en) Bronchiopulmonary occlusion devices and lung volume reduction methods
EP1284663A1 (en) Bronchiopulmonary occlusion devices and lung volume reduction methods
CN101541365A (en) Tracheostoma tracheotomy method and device
US20030045859A1 (en) Delivery system using balloon catheter
US6409652B1 (en) Device and method for delivery of uniform and controlled radiation dose to blood vessels
CN110811927A (en) Implant loading device
JP2013188252A (en) Stent delivery system and balloon catheter system
CN109893314B (en) Silicone stent conveying device
CN110742667A (en) Methods and devices for treating pulmonary dysfunction using implantable valves
US8945201B2 (en) Prosthesis delivery system
WO2017054015A2 (en) Methods or devices for intra-bronchial delivery of lung hyperinflation treatment
CN115414165A (en) Handheld TIPS stent compression device and method
WO2018081084A1 (en) Methods and devices for delivery of lung device
US20090099666A1 (en) Spongy implant

Legal Events

Date Code Title Description
FZDE Discontinued